MCID: LYM024
MIFTS: 49

Lymphatic System Disease

Categories: Immune diseases

Aliases & Classifications for Lymphatic System Disease

MalaCards integrated aliases for Lymphatic System Disease:

Name: Lymphatic System Disease 12 14
Lymphatic Diseases 41 42 69
Disorder of Lymph Node and Lymphatics 12
Abnormality of the Lymphatic System 29
Disorder of Lymphatic System 12
Disorder of Lymphoid System 12
Disease of Lympoid System 12
Lympoid System Disease 12
Lymphangiopathy, Nos 12
Lymphatic Disorder 12
Lymphatic Disease 12
Adenopathy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:75
MeSH 42 D008206
UMLS 69 C0024228

Summaries for Lymphatic System Disease

MedlinePlus : 41 the lymphatic system is a network of tissues and organs. it is made up of lymph - a fluid that contains white blood cells that defend against germs lymph vessels - vessels that carry lymph throughout your body. they are different from blood vessels. lymph nodes - glands found throughout the lymph vessels. along with your spleen, these nodes are where white blood cells fight infection. your bone marrow and thymus produce the cells in lymph. they are part of the system, too. the lymphatic system clears away infection and keeps your body fluids in balance. if it's not working properly, fluid builds in your tissues and causes swelling, called lymphedema. other lymphatic system problems can include infections, blockage, and cancer.

MalaCards based summary : Lymphatic System Disease, also known as lymphatic diseases, is related to periodic fever, aphthous stomatitis, pharyngitis and adenitis and limbic encephalitis with nmda receptor antibodies, and has symptoms including edema, axillary lymph node pain and axillary lymph node tenderness. An important gene associated with Lymphatic System Disease is UNC13D (Unc-13 Homolog D), and among its related pathways/superpathways are Lysosome and LDL Oxidation in Atherogenesis. The drugs Azithromycin and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An immune system disease that is located in the lymphatic system.

Wikipedia : 72 The lymphatic system is part of the circulatory system and a vital part of the immune system, comprising... more...

Related Diseases for Lymphatic System Disease

Diseases related to Lymphatic System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
id Related Disease Score Top Affiliating Genes
1 periodic fever, aphthous stomatitis, pharyngitis and adenitis 11.0
2 limbic encephalitis with nmda receptor antibodies 10.9 NPC1 NPC2
3 congenital enterovirus infection 10.9 NPC1 NPC2
4 mucopolysaccharidosis type 2, attenuated form 10.9 NPC1 NPC2
5 mucopolysaccharidosis type 2, severe form 10.9 NPC1 NPC2
6 pulmonary fungal infections in patients deemed at risk 10.9 NPC1 NPC2
7 ataxia with vitamin e deficiency 10.9 NPC1 SMPD1
8 follicular lymphoma 10.8
9 systemic onset juvenile idiopathic arthritis 10.8
10 thyroid dyshormonogenesis 4 10.8 STX11 STXBP2 UNC13D
11 hemophagocytic lymphohistiocytosis 10.7
12 hennekam syndrome 10.7
13 histiocytosis 10.7
14 lymphangitis 10.7
15 atrioventricular septal defect 5 10.7 NPC1 NPC2 SMPD1
16 hyper-igd syndrome 10.7
17 mycosis fungoides 10.7
18 astrakhan spotted fever 10.7
19 indian tick typhus 10.7
20 israeli tick typhus 10.7
21 far eastern spotted fever 10.7
22 flinders island spotted fever 10.7
23 japanese spotted fever 10.7
24 siberian tick typhus 10.7
25 boutonneuse fever 10.7
26 dysostosis 10.7 NPC1 NPC2 SMPD1
27 uterine corpus cancer 10.7 NPC1 NPC2 SMPD1
28 carcinoid tumors, intestinal 10.7 SDHB SDHD
29 neurogenic hypertension 10.7 SDHB SDHD
30 osteochondritis dissecans 10.7 NPC1 NPC2 SMPD1
31 rete ovarii cystadenoma 10.6 SDHB SDHD
32 paraganglioma and gastric stromal sarcoma 10.6 SDHB SDHD
33 lymphangiectasia, pulmonary, congenital 10.6
34 yellow nail syndrome 10.6
35 hereditary lymphedema 10.6
36 cardiomyopathy, dilated, 1u 10.6 NPC1 NPC2 SMPD1
37 gummatous syphilis 10.6 FLT4 FOXC2 GJC2
38 uterine corpus endometrial carcinoma 10.6 SDHB SDHD
39 congenital mitral stenosis 10.5 FLT4 FOXC2 VEGFC
40 brown's tendon sheath syndrome 10.5 CD40LG SDHD
41 x inactivation, familial skewed, 2 10.5 SH2D1A STXBP2
42 mercaptolactate-cysteine disulfiduria 10.5 SDHB SDHD
43 renal adenoma 10.5 FLT4 GJC2 VEGFC
44 oculo-cerebral dysplasia 10.4 CD40LG TLR9
45 lung abscess 10.4 CD40LG SDHB SDHD
46 heart fibrosarcoma 10.4 CD40LG SH2D1A STXBP2
47 gestational diabetes 10.4 CD40LG SH2D1A STXBP2
48 hepatitis b 10.4 SH2D1A STX11 STXBP2 UNC13D
49 muscle cancer 10.3 CD40LG CD68
50 malignant melanocytic peripheral nerve sheath tumor of mediastinum 10.3 CD40LG SH2D1A TLR9

Graphical network of the top 20 diseases related to Lymphatic System Disease:



Diseases related to Lymphatic System Disease

Symptoms & Phenotypes for Lymphatic System Disease

UMLS symptoms related to Lymphatic System Disease:


edema, axillary lymph node pain, axillary lymph node tenderness

MGI Mouse Phenotypes related to Lymphatic System Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 CD207 CD40LG CD68 GJC2 ITPKC NPC1
2 homeostasis/metabolism MP:0005376 9.93 SH2D1A SMPD1 STX11 TLR9 UNC13D VEGFC
3 immune system MP:0005387 9.86 ITPKC NPC1 NPC2 SH2D1A SMPD1 STX11
4 mortality/aging MP:0010768 9.4 CD40LG FLT4 FOXC2 GJC2 NPC1 NPC2

Drugs & Therapeutics for Lymphatic System Disease

Drugs for Lymphatic System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 974)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Azithromycin Approved Phase 4,Phase 3,Phase 1,Phase 2 83905-01-5 55185 53477736 447043
2
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
3
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 9015-68-3
4
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 4291-63-8 20279
5
Cyclophosphamide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
6
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 147-94-4 6253
7
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
8
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
9
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 23214-92-8 31703
10
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
11
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751
12
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
13
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
16
Teniposide Approved Phase 4,Phase 3,Phase 2,Phase 1 29767-20-2 34698
17
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
18
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2068-78-2, 57-22-7 5978
19
Vindesine Approved Phase 4,Phase 3,Phase 2,Phase 1 59917-39-4, 53643-48-4 40839
20
Azathioprine Approved Phase 4,Phase 3,Early Phase 1 446-86-6 2265
21
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 130167-69-0
22
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
23
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 174722-31-7 10201696
24
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
25
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53910-25-1 40926 439693
26
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
27
Vidarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 24356-66-9 32326 21704
28
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
29
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 65271-80-9 4212
30
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 55-98-1 2478
31
Denileukin diftitox Approved, Investigational Phase 4,Phase 2,Phase 1 173146-27-5
32 Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
33
Entecavir Approved, Investigational Phase 4,Phase 2 142217-69-4 153941
34
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
35
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
36
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
37
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
38
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
39
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
40
Melphalan Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 148-82-3 4053 460612
41
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
42
Bortezomib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 179324-69-7 387447 93860
43
Bleomycin Approved Phase 4,Phase 3,Phase 2,Phase 1 11056-06-7 5360373
44
Dacarbazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 4342-03-4 5351166
45
Epirubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 56420-45-2 41867
46
Menthol Approved Phase 4,Phase 3,Phase 2,Phase 1 2216-51-5 16666
47
Vinblastine Approved Phase 4,Phase 3,Phase 2,Phase 1 865-21-4 13342 241903
48
Mechlorethamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-75-2 4033
49
Gemcitabine Approved Phase 4,Phase 3,Phase 2,Phase 1 95058-81-4 60750
50
Oxaliplatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599

Interventional clinical trials:

(show top 50) (show all 5898)

id Name Status NCT ID Phase Drugs
1 The Efficacy of Prednisone and Azithromycin in the Treatment of Patients With Cat Scratch Disease Unknown status NCT01469702 Phase 4 prednison and azithromycin;prednison, azithromycin;prednison, Azenil
2 Optimization of the Primary Therapy for Patients With Hodgkin's Disease and Evaluation of PET Unknown status NCT00188149 Phase 4 Combined chemotherapy (ABVD, BACOPP-D)
3 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
4 Clinical Trial Comparing Outcomes of Breast Conserving Operations With Classic v High-frequency Electrocoagulation Unknown status NCT01216254 Phase 4
5 CHUSPAN SCS BP Treatment of Churg–Strauss Syndrome Without Poor-Prognosis Factors Unknown status NCT00399399 Phase 4 azathioprine;cyclophosphamide
6 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
7 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
8 MR-Lymphography and Lymph Node Staging in Prostate Cancer Unknown status NCT00185029 Phase 4
9 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
10 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
11 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
12 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
13 Treatment of Good Prognosis, BCL-6 Negative Diffuse Large Cell Lymphoma With CHOP-R in Patients < 61 Years Old. Unknown status NCT00429065 Phase 4 Rituximab
14 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
15 Effectiveness of Intracavitary Manual Lymphatic Drainage Completed NCT02960841 Phase 4
16 Effects of Losartan and Antiretroviral Regimen Containing Raltegravir in Fibrosis Inflammation Mediators, Cardiovascular Risk and Neurocognitive Disorders in HIV Infected Patients Previously Effectively Treated Completed NCT01529749 Phase 4 EFV/FTC/TDF + Losartan;EFV/FTC/TDF;FTC/TDF + MK-0518;FTC/TDF+MK-0518+Losartan
17 Fludarabine, Cyclophosphamide, Doxorubicin and Rituximab for the Treatment of Post-transplant Lymphoproliferative Disease (PTLD) Completed NCT01088724 Phase 4 fludarabine, cyclophosphamide, doxorubicin, rituximab
18 Randomised Controlled Trial of Mechanistic Effects of Rifaximin in Cirrhosis and Chronic Hepatic Encephalopathy Completed NCT02019784 Phase 4 Rifaximin-α;Placebo Oral Tablet
19 A Study of the Quality of Life and Treatment Response to Once Weekly Epoetin Beta (Recormon) Treatment in Anemic Participants With Solid and Lymphoid Malignancies Completed NCT00776425 Phase 4 Epoetin beta
20 Life Quality and Mental State in Patients With Breast Cancer Completed NCT01458457 Phase 4
21 A Phase IV Study of Recombinant Human Gamma Interferon in Patients With Chronic Granulomatous Diseases of Childhood Completed NCT00001317 Phase 4 interferon-gamma
22 Study of Combined Therapy of Aspirin and "IVIG-SN" in Kawasaki Disease Completed NCT01524939 Phase 4 immunoglobulin G
23 An Observational Study of Lymphoma in Patients With Rheumatoid Arthritis or Crohn's Disease. Completed NCT00440817 Phase 4
24 Certolizumab and Lower Extremity Lymph Flow in Rheumatoid Arthritis (RA) Completed NCT01098201 Phase 4 Certolizumab
25 Carbohydrate Metabolism Disorder Frequency in Hypertriglyceridemia Induced by Bexarotene of Cutaneous T Cell Lymphoma Completed NCT01569724 Phase 4
26 Efficacy Response Duration and Toxicity of Rituximab, Fludarabine, and Cyclophosphamide (RFC) as 1st Line Treatment and Rituximab (R) in Maintenance Treatment in Follicular Non Hodgkin (FNH) Lymphoma Completed NCT01124526 Phase 4 Rituximab Fludarabine Cyclophosphamide
27 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
28 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
29 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
30 Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection Completed NCT02005653 Phase 4 Diethylcarbamazine;Albendazole;Doxycycline
31 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4 Ofatumumab
32 Study of Rasburicase as Treatment or Prevention of Hyperuricemia Associated With Tumor Lysis Syndrome in Patients With Relapsed or Refractory Lymphoma, Leukemia, or Solid Tumor Malignancy Completed NCT00230217 Phase 4 Rasburicase (SR29142)
33 A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Completed NCT01289847 Phase 4
34 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
35 Busulfan Safety/Efficacy as Conditioning Prior to Hematopoietic Cell Transplantation (HCT) Completed NCT00361140 Phase 4 Busulfan;Fludarabine
36 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
37 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
38 Study of ONTAK (Denileukin Diftitox) in Cutaneous T-Cell Lymphoma (CTCL) Patients Completed NCT00050999 Phase 4 ONTAK
39 Low Level Laser Treatment and Breast Cancer Related Lymphedema Completed NCT00852930 Phase 4
40 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
41 Hepatitis B Virus Reactivation After Withdrawal of Prophylactic Antiviral Therapy in Lymphoma Patients Completed NCT02108444 Phase 4
42 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
43 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
44 Zevalin® Followed by Rituxan® Maintenance in Previously Treated Low Grade Non-Hodgkin’s Lymphoma Completed NCT00168727 Phase 4 ibritumomab tiuxetan (Zevalin®)
45 Study Evaluating Two Dose Levels of Targretin Capsules in Patients With Refractory Cutaneous T-cell Lymphoma (CTCL) Completed NCT01007448 Phase 4 bexarotene;bexarotene
46 Doxycycline In Lymphangioleiomyomatosis (LAM) Completed NCT00989742 Phase 4 Doxycycline;Placebo
47 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
48 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
49 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
50 Inhaled Iloprost for Sarcoidosis-associated Pulmonary Hypertension Completed NCT00403650 Phase 4 Iloprost

Search NIH Clinical Center for Lymphatic System Disease

Cochrane evidence based reviews: lymphatic diseases

Genetic Tests for Lymphatic System Disease

Genetic tests related to Lymphatic System Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Lymphatic System 29

Anatomical Context for Lymphatic System Disease

MalaCards organs/tissues related to Lymphatic System Disease:

39
B Cells, T Cells, Bone, Bone Marrow, Breast, Lymph Node, Myeloid

Publications for Lymphatic System Disease

Variations for Lymphatic System Disease

Expression for Lymphatic System Disease

Search GEO for disease gene expression data for Lymphatic System Disease.

Pathways for Lymphatic System Disease

Pathways related to Lymphatic System Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.01 CD68 NPC1 NPC2 SMPD1
2 10.36 CD68 SMPD1
3
Show member pathways
10.1 NPC1 NPC2

GO Terms for Lymphatic System Disease

Cellular components related to Lymphatic System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 CD40LG FLT4 NPC1 NPC2 SMPD1 STXBP2
2 endosome GO:0005768 9.65 CD68 NPC1 SMPD1 TLR9 UNC13D
3 lysosome GO:0005764 9.35 NPC1 NPC2 SMPD1 TLR9 UNC13D
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.62 SDHB SDHD

Biological processes related to Lymphatic System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lymph vessel development GO:0001945 9.26 FLT4 FOXC2
2 lymphangiogenesis GO:0001946 9.16 FLT4 FOXC2
3 regulation of mast cell degranulation GO:0043304 8.96 STXBP2 UNC13D
4 vascular endothelial growth factor receptor signaling pathway GO:0048010 8.8 FLT4 FOXC2 VEGFC

Molecular functions related to Lymphatic System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ubiquinone binding GO:0048039 8.96 SDHB SDHD
2 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.62 SDHB SDHD

Sources for Lymphatic System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....