MCID: LYM025
MIFTS: 56

Lymphedema malady

Cardiovascular diseases, Immune diseases categories

Summaries for Lymphedema

About this section
Sources:
33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Lymphedema is the name of a type of swelling. it happens when lymph builds up in your body's soft tissues. lymph is a fluid that contains white blood cells that defend against germs. it can build up when the lymph system is damaged or blocked. it usually happens in the arms or legs. causes of lymphedema include infection cancer scar tissue from radiation therapy or surgical removal of lymph nodes inherited conditions in which lymph nodes or vessels are absent or abnormal treatment can help control symptoms. it includes exercise, compression devices, skin care, and massage. nih: national cancer institute

MalaCards: Lymphedema, also known as lymphedema, acquired, is related to breast cancer and lymphedema-distichiasis syndrome. An important gene associated with Lymphedema is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are p70S6K Signaling and Heart Development. The compound vegf have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and skin, and related mouse phenotypes are pigmentation and normal.

CDC:3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

Wikipedia:63 Lymphedema (lymphoedema in British English), also known as lymphatic obstruction, is a condition of... more...

Aliases & Classifications for Lymphedema

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Immune diseases


Aliases & Descriptions:

lymphedema 8 10 44 33 60
lymphedema, acquired 8
lymphatic edema 8
lymphoedema nos 8
lymphoedema 8


External Ids:

Disease Ontology8 DOID:4977
NCIt39 C3207
MeSH34 D008209
ICD1025 I89.0

Related Diseases for Lymphedema

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Lymphedema family:

Lymphedema, Congenital Congenital Primary Lymphedema

Diseases related to Lymphedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2SOX18, FOXC1, GATA2, FLT4, PROX1, VEGFC
2lymphedema-distichiasis syndrome30.9FOXC2
3lymphangiosarcoma30.9PROX1
4yellow nail syndrome30.6SOX18
5angiosarcoma30.4PDPN, FLT4, VEGFC
6lymphedema, congenital30.3FIGF, VEGFC, FOXC2, PDPN, FLT4
7mongolian spot30.1FOXC2, SOX18
8hypotrichosis30.1SOX18
9sarcoma30.0FLT4
10squamous cell carcinoma29.9OXA1L, PDPN, FLT4, VEGFC, FIGF
11klippel-trenaunay syndrome29.7FOXC2, SOX18, FLT4
12inflammatory breast carcinoma29.7VEGFC, FIGF, PROX1
13kaposi's sarcoma29.7VEGFC, FLT4, PDPN
14prostate cancer29.7VEGFC, FLT4, PDPN, FIGF, OXA1L
15hereditary lymphedema10.7
16hereditary lymphedema type ii10.4
17elephantiasis10.4
18meige lymphedema10.4
19hennekam syndrome10.3
20aagenaes syndrome10.3
21hypotrichosis-lymphedema-telangiectasia syndrome10.3
22erysipelas10.2
23microcephaly10.2
24obesity10.2
25breast reconstruction10.2
26filariasis10.2
27microcephaly with or without chorioretinopathy, lymphedema, or mental retardation10.2
28lymphedema and cerebral arteriovenous anomaly10.2
29lymphangitis10.1
30chorioretinitis10.1
31melanoma10.1
32lymphedema, microcephaly and chorioretinopathy syndrome10.1
33hereditary lymphedema ic10.1
34arthritis10.1
35tuberous sclerosis10.1
36filarial elephantiasis10.1
37cervical cancer10.1
38cervicitis10.1
39lymph node cancer10.1
40turner syndrome10.1
41dahlberg borer newcomer syndrome10.1
42lymphedema - atrial septal defects - facial changes10.1
43lymphangioleiomyomatosis10.0
44noonan syndrome10.0
45arachnoiditis10.0
46protein-losing enteropathy10.0
47podoconiosis10.0
48lymphedema, primary, with myelodysplasia10.0
49ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency10.0
50congenital primary lymphedema10.0

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to lymphedema

Clinical Features for Lymphedema

About this section

Drugs & Therapeutics for Lymphedema

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphedema

Drug clinical trials:

Search ClinicalTrials for Lymphedema

Search NIH Clinical Center for Lymphedema

Search CenterWatch for Lymphedema

Genetic Tests for Lymphedema

About this section

Anatomical Context for Lymphedema

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Lymphedema:

32
Breast, Lymph node, Skin, Endothelial, Bone, B cells, T cells, Nk cells, Monocytes, Myeloid, Prostate, Colon, Brain, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Lymphedema:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Potential therapeutic candidate, affected by disease

Animal Models for Lymphedema or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Lymphedema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.4FOXC2, SOX18
2MP:000287310.2CCBE1, SOX18, FOXC2, FOXC1, GATA2, FLT4
3MP:000537010.1CCBE1, FOXC2, FOXC1, GATA2, FLT4, PROX1
4MP:000538510.1SOX18, PDPN, FOXC2, FOXC1, GATA2, FLT4
5MP:000538710.1FOXC2, PDPN, SOX18, CCBE1, FLT4, PROX1
6MP:000537810.0FOXL1, FOXC1, FOXC2, PDPN, SOX18, GATA2
7MP:000538110.0PDPN, FOXC2, FOXC1, FOXL1, FLT4, PROX1
8MP:001076810.0KIF11, CCBE1, SOX18, PDPN, FOXC2, FOXC1
9MP:00053769.9FOXC1, FOXC2, PDPN, SOX18, CCBE1, GATA2
10MP:00053759.9FOXC2, FLT4, PROX1, FIGF, IKBKG

Publications for Lymphedema

About this section
Sources:
50PubMed
See all sources

Articles related to Lymphedema:

(show top 50)    (show all 685)
idTitleAuthorsYear
1
Effects of qigong exercise on upper limb lymphedema and blood flow in survivors of breast cancer: a pilot study. (23749481)
2014
2
Congenital Segmental Lymphedema in Tuberous Sclerosis Complex With Associated Subependymal Giant Cell Astrocytomas Treated with Mammalian Target of Rapamycin Inhibitors. (24056156)
2013
3
Comparison of lymphedema in patients with axillary lymph node dissections to those with sentinel lymph node biopsy followed by immediate and delayed ALND. (22157215)
2013
4
Massive Localized Lymphedema of the Vulva: Report of a Case and Review of the Literature. (24189310)
2013
5
Intensive complete decongestive physiotherapy for cancer-related upper-limb lymphedema: 11 days achieved greater volume reduction than 4. (23906654)
2013
6
Congenital chylous ascites and lymphedema in Down's syndrome: correspondence. (23737368)
2013
7
Assessment of external lymphedema in patients with head and neck cancer: a comparison of four scales. (23989023)
2013
8
Lymphedema: experience of a cohort of women with breast cancer followed for 4 years after diagnosis in Victoria, Australia. (23435596)
2013
9
Defining a threshold for intervention in breast cancer-related lymphedema: what level of arm volume increase predicts progression? (23912961)
2013
10
Mutations in the VEGFR3 signaling pathway explain 36% of familial lymphedema. (24167460)
2013
11
Leg lymphedema caused by iliopectineal bursitis associated with destruction of a rheumatoid hip joint: A case report. (24137283)
2013
12
Whole-body bioelectrical impedance analysis in assessing upper-limb lymphedema after breast cancer therapy. (24123030)
2013
13
Neutrophilic dermatosis on postmastectomy lymphedema. (22677124)
2012
14
Liposuction normalizes - in contrast to other therapies - lymphedema-induced adipose tissue hypertrophy. (23283813)
2012
15
Current views on diagnostic approach and treatment of lymphedema. (22269614)
2012
16
GATA-2 anomaly and clinical phenotype of a sporadic case of lymphedema, dendritic cell, monocyte, B- and NK-cell (DCML) deficiency, and myelodysplasia. (22430350)
2012
17
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. (22284827)
2012
18
Breast cancer-related lymphedema: comparing direct costs of a prospective surveillance model and a traditional model of care. (21921254)
2012
19
Verruciform xanthoma: localized lymphedema (elephantiasis) is an essential pathogenic factor. (21362016)
2012
20
Using indocyanine green fluorescent lymphography and lymphatic-venous anastomosis for cancer-related lymphedema. (22079465)
2012
21
Time-course of arm lymphedema and potential risk factors for progression of lymphedema after breast conservation treatment for early stage breast cancer. (22487094)
2012
22
Microvascular breast reconstruction and lymph node transfer for postmastectomy lymphedema patients. (22233832)
2012
23
A prospective study in detection of lower-limb lymphedema and evaluation of quality of life after vulvar cancer surgery. (22683942)
2012
24
Lower limb lymphedema treated with lymphatico-venous anastomosis based on pre- and intraoperative icg lymphography and non-contact vein visualization: A case report. (22262581)
2012
25
Upper-limb lymphedema treated aesthetically with lymphaticovenous anastomosis using indocyanine green lymphography and noncontact vein visualization. (22517571)
2012
26
Sentinel lymph node biopsy at the time of mastectomy does not increase the risk of lymphedema: implications for prophylactic surgery. (22941538)
2012
27
Development of a pressure-measuring device to optimize compression treatment of lymphedema and evaluation of change in garment pressure with simulated wear and tear. (22720662)
2012
28
Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery. (23700765)
2012
29
Idiopathic portal hypertension and lower limb lymphedema. (23057151)
2012
30
Nursing education on lymphedema self-management and self-monitoring in a South African oncology clinic. (22288209)
2011
31
Lymphedema in patients with head and neck cancer. (21186146)
2011
32
Massive localized lymphedema: A case series and literature review. (22942667)
2011
33
Characteristic indocyanine green lymphography findings in lower extremity lymphedema: the generation of a novel lymphedema severity staging system using dermal backflow patterns. (21532424)
2011
34
Idiopathic chylothorax and lymphedema in 2 whippet littermates. (22547848)
2011
35
Global efforts address wounds and lymphedema. (21488417)
2010
36
Large nodular plaque on leg in the setting of chronic lymphedema--quiz case. Angiosarcoma in the setting of familial lymphedema. (20231513)
2010
37
Vascular defects in a mouse model of hypotrichosis-lymphedema-telangiectasia syndrome indicate a role for SOX18 in blood vessel maturation. (19429912)
2009
38
Lymphedema-distichiasis syndrome without FOXC2 mutation: evidence for chromosome 16 duplication upstream of FOXC2. (20218083)
2009
39
Cutaneous tumors, massive lymphadenopathy, and secondary lymphedema in a 16-year-old boy--quiz case. African/endemic Kaposi sarcoma (KS): lymphadenopathic form. (18794470)
2008
40
Elephantiasis nostras verrucosa or "mossy foot lesions" in lymphedema praecox: report of a case. (18202337)
2008
41
Candidate gene analysis in primary lymphedema. (18564921)
2008
42
An experimental model for the study of lymphedema and its response to therapeutic lymphangiogenesis. (17176124)
2006
43
Yellow nail syndrome in an infant presenting with lymphedema of the eyelids and pleural effusion. (15248011)
2004
44
Mutations in FOXC2 (MFH-1), a forkhead family transcription factor, are responsible for the hereditary lymphedema-distichiasis syndrome. (11078474)
2000
45
Mapping of the locus for cholestasis-lymphedema syndrome (Aagenaes syndrome) to a 6.6-cM interval on chromosome 15q. (10968776)
2000
46
Lymphedema-Distichiasis Syndrome (20301630)
1993
47
Electron microscopic observations of lymphangiosarcoma arising from chronic lymphedema. (6624459)
1983
48
Scintilymphangiography with 99 mTc-antimony sulfide colloid in hereditary lymphedema (Nonne-Milroy diseases). (709985)
1978
49
Hereditary lymphedema and obstructive jaundice. (5544157)
1971
50
Prophylaxis of recurrent lymphangitis complicating lymphedema. (12608187)
1966

Genetic Variations for Lymphedema

About this section

Expression for genes affiliated with Lymphedema

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphedema

Search GEO for disease gene expression data for Lymphedema.

Pathways for genes affiliated with Lymphedema

About this section
Sources:
51QIAGEN, 37NCBI BioSystems Database, 49PharmGKB, 55SinoBiological, 12EMD Millipore, 53Reactome, 29KEGG
See all sources

Compounds for genes affiliated with Lymphedema

About this section
Sources:
44Novoseek
See all sources

Compounds related to Lymphedema according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vegf4410.2FIGF, VEGFC, PROX1, FLT4, PDPN

GO Terms for genes affiliated with Lymphedema

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.9PTPN14, SOX18, FOXC2, FOXC1, FOXL1, GATA2

Biological processes related to Lymphedema according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1embryonic heart tube developmentGO:03505010.7FOXC1, FOXC2, SOX18
2positive regulation of mast cell chemotaxisGO:06075410.7VEGFC, FIGF
3endocardium formationGO:06021410.7SOX18, PROX1
4venous blood vessel morphogenesisGO:04884510.7PROX1, CCBE1
5lymph vessel developmentGO:00194510.7FLT4, FOXC1
6positive regulation of endothelial cell migrationGO:01059510.7PROX1, FLT4, FOXC2
7lymphatic endothelial cell differentiationGO:06083610.7PROX1, SOX18
8camera-type eye developmentGO:04301010.7FOXL1, FOXC1, FOXC2
9ventricular cardiac muscle tissue morphogenesisGO:05501010.7FOXC2, FOXC1, PROX1
10regulation of organ growthGO:04662010.6FOXC2, FOXC1
11cardiac muscle cell proliferationGO:06003810.6FOXC2, FOXC1
12regulation of blood vessel sizeGO:05088010.6FOXC2, FOXC1
13vascular endothelial growth factor receptor signaling pathwayGO:04801010.6FOXC2, FOXC1, FLT4, VEGFC, FIGF
14induction of positive chemotaxisGO:05093010.5VEGFC, FIGF
15neural crest cell developmentGO:01403210.5FOXC2, FOXC1
16embryo developmentGO:00979010.5FOXL1, FOXC1, PDPN
17lymphangiogenesisGO:00194610.5PTPN14, PROX1, FLT4, FOXC2, PDPN, SOX18
18negative regulation of transcription from RNA polymerase II promoterGO:00012210.5PROX1, GATA2, FOXC1, FOXC2, SOX18
19sprouting angiogenesisGO:00204010.5FLT4, CCBE1
20artery morphogenesisGO:04884410.4FOXC2, FOXC1
21positive regulation of transcription from RNA polymerase II promoterGO:04594410.4SOX18, FOXC2, FOXC1, GATA2, IKBKG
22heart developmentGO:00750710.3FOXL1, FOXC1, FOXC2
23vasculature developmentGO:00194410.3FLT4, SOX18
24tissue developmentGO:00988810.1FOXL1, FOXC1

Molecular functions related to Lymphedema according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor 3 bindingGO:04318510.5FIGF, VEGFC
2DNA binding, bendingGO:00830110.4FOXL1, FOXC1, FOXC2
3transcription regulatory region DNA bindingGO:04421210.4SOX18, FOXC2, FOXC1, PROX1
4chemoattractant activityGO:04205610.4FIGF, VEGFC
5RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:00107710.3SOX18, FOXC2, GATA2
6sequence-specific DNA binding transcription factor activityGO:00370010.1FOXC2, FOXC1, FOXL1, GATA2, PROX1, SHOX
7RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.0PROX1, FOXC1, FOXC2

Products for genes affiliated with Lymphedema

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphedema

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet