MCID: LYM025
MIFTS: 60

Lymphedema

Categories: Immune diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Lymphedema

MalaCards integrated aliases for Lymphedema:

Name: Lymphedema 38 12 29 52 41 3 42 14 69
Lymphatic Edema 12
Lymphoedema Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4977
MeSH 42 D008209
NCIt 47 C3207
UMLS 69 C0024236

Summaries for Lymphedema

MedlinePlus : 41 lymphedema is the name of a type of swelling. it happens when lymph builds up in your body's soft tissues. lymph is a fluid that contains white blood cells that defend against germs. it can build up when the lymph system is damaged or blocked. it usually happens in the arms or legs. causes of lymphedema include infection cancer scar tissue from radiation therapy or surgical removal of lymph nodes inherited conditions in which lymph nodes or vessels are absent or abnormal treatment can help control symptoms. it includes exercise, compression devices, skin care, and massage. nih: national cancer institute

MalaCards based summary : Lymphedema, also known as lymphatic edema, is related to lymphedema-distichiasis syndrome and hereditary lymphedema, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Lymphedema is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are PAK Pathway and p70S6K Signaling. The drugs Ivermectin and Azithromycin have been mentioned in the context of this disorder. Affiliated tissues include Heart, breast and lymph node, and related phenotypes are cardiovascular system and growth/size/body region

CDC : 3 Lymphatic filariasis, considered globally as a neglected tropical disease , is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

Wikipedia : 72 Lymphedema, also known as lymphoedema and lymphatic edema, is a condition of localized fluid retention... more...

Related Diseases for Lymphedema

Diseases in the Lymphedema family:

Lymphedema, Hereditary, Ic Lymphedema, Hereditary, Id
Lymphedema, Hereditary, Ia Lymphedema, Hereditary, Ib
Lymphedema, Hereditary, Iii Hereditary Lymphedema
Congenital Lymphedema Hereditary Lymphedema Type Ii

Diseases related to Lymphedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
id Related Disease Score Top Affiliating Genes
1 lymphedema-distichiasis syndrome 12.4
2 hereditary lymphedema 12.3
3 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 12.3
4 hypotrichosis-lymphedema-telangiectasia syndrome 12.3
5 hereditary lymphedema type ii 12.3
6 cholestasis-lymphedema syndrome 12.2
7 choanal atresia and lymphedema 12.1
8 lymphedema, hereditary, ia 12.1
9 lymphedema, hereditary, ic 12.1
10 lymphedema, hereditary, iii 12.1
11 hennekam lymphangiectasia-lymphedema syndrome 2 12.1
12 hennekam lymphangiectasia-lymphedema syndrome 1 12.0
13 lymphedema, hereditary, id 12.0
14 ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency 12.0
15 deafness-lymphedema-leukemia syndrome 12.0
16 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 12.0
17 lymphedema, hereditary, ib 11.9
18 hennekam syndrome 11.9
19 congenital lymphedema 11.9
20 yellow nail syndrome 11.8
21 lymphedema and cerebral arteriovenous anomaly 11.8
22 lymphedema, cardiac septal defects, and characteristic facies 11.7
23 lymphedema-hypoparathyroidism syndrome 11.7
24 emberger syndrome 11.7
25 macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndrome 11.6
26 lymphangiosarcoma 11.6
27 dahlberg borer newcomer syndrome 11.3
28 podoconiosis 11.0
29 turner syndrome 11.0
30 bier spots 11.0
31 irons bhan syndrome 10.8
32 filarial elephantiasis 10.8
33 immunodeficiency 21 10.7
34 angiosarcoma of the scalp 10.7
35 kanzaki disease 10.7
36 oculodentodigital dysplasia 10.7
37 verruciform xanthoma of skin 10.7
38 immunodeficiency 33 10.7
39 lymphatic system disease 10.7
40 takenouchi-kosaki syndrome 10.7
41 breast cancer 10.6
42 adie pupil 10.5 FOXC2 SOX18
43 miyoshi muscular dystrophy 2 10.5 FLT4 FOXC2 SOX18
44 synpolydactyly 10.4 CCBE1 FAT4
45 sleep apnea 10.3 FOXC2 GJC2 SOX18
46 tuberculosis 10.3 FOXC2 GJC2 SOX18
47 bipartite talus 10.3 CCBE1 PIEZO1
48 lymphocytic vasculitis 10.3 FLT4 PROX1
49 vascular hemostatic disease 10.3 FLT4 PROX1
50 distichiasis 10.2

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to Lymphedema

Symptoms & Phenotypes for Lymphedema

UMLS symptoms related to Lymphedema:


angina pectoris, chest pain, edema, localized edema, joint swelling

MGI Mouse Phenotypes related to Lymphedema:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 FAT4 FLT4 FOXC2 GATA2 IKBKG KDR
2 growth/size/body region MP:0005378 10.15 FAT4 FLT4 FOXC2 GATA2 IKBKG KDR
3 homeostasis/metabolism MP:0005376 10.1 CCBE1 FLT4 FOXC2 GATA2 IKBKG KDR
4 immune system MP:0005387 10.03 CCBE1 FLT4 FOXC2 GJC2 IKBKG KDR
5 embryo MP:0005380 10.01 FAT4 FLT4 FOXC2 GATA2 KDR KIF11
6 digestive/alimentary MP:0005381 9.91 FAT4 FLT4 FOXC2 IKBKG PROX1 SOX18
7 mortality/aging MP:0010768 9.83 FAT4 FLT4 FOXC2 GATA2 GJC2 IKBKG
8 liver/biliary system MP:0005370 9.7 FLT4 FOXC2 GATA2 IKBKG KDR PROX1
9 normal MP:0002873 9.32 FOXC2 GATA2 GJC2 IKBKG KDR PIEZO1

Drugs & Therapeutics for Lymphedema

Drugs for Lymphedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 141)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 70288-86-7 6474909 46936176
2
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
3
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54965-21-8 2082
4
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
5 Radiopharmaceuticals Phase 4,Phase 2
6 penicillins Phase 4
7 Fibrin Tissue Adhesive Phase 4,Phase 3
8 Coagulants Phase 4,Phase 3
9 Hemostatics Phase 4,Phase 3
10 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1
11 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
12 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
13 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
14 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
15 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
17
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
18
Glycerol Approved, Investigational Phase 3 56-81-5 753
19
Doxycycline Approved, Investigational, Vet_approved Phase 3,Phase 2 564-25-0 54671203
20
Ropivacaine Approved Phase 3 84057-95-4 71273 175805
21
Petrolatum Approved Phase 3 8009-03-8
22
Rifampin Approved Phase 2, Phase 3 13292-46-1 5458213 5381226
23
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
24
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
25 Anesthetics Phase 3
26 Anesthetics, Local Phase 3
27 Sodium hypochlorite Phase 3
28 Central Nervous System Depressants Phase 3
29 Disinfectants Phase 3
30 Peripheral Nervous System Agents Phase 3
31 Eusol Phase 3
32 Protective Agents Phase 3,Phase 2
33 Antimalarials Phase 3,Phase 2
34 Pharmaceutical Solutions Phase 3,Phase 2
35 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
36 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
37 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
38 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
39 Antitubercular Agents Phase 2, Phase 3
40
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
41
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
42
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
43
Selenium Approved, Vet_approved Phase 2 7782-49-2
44
Diethylcarbamazine Approved, Vet_approved Phase 2,Phase 1 90-89-1 3052
45
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
46
Selenious acid Approved Phase 2 7783-00-8
47
Digoxin Approved Phase 2 20830-75-5 30322 2724385
48
Propranolol Approved, Investigational Phase 2 525-66-6 4946
49 Tocopherol Approved, Nutraceutical Phase 2
50
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985

Interventional clinical trials:

(show top 50) (show all 310)

id Name Status NCT ID Phase Drugs
1 Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema Completed NCT01068431 Phase 4
2 Low Level Laser Treatment and Breast Cancer Related Lymphedema Completed NCT00852930 Phase 4
3 Home-based Compression Therapy for Arm and Truncal Lymphedema in Breast Cancer Completed NCT00880022 Phase 4
4 Comparison Between a Non-elastic Falcro Device and Current Method After Total Knee Arthroplasty Completed NCT02375945 Phase 4
5 A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction Completed NCT01561287 Phase 4
6 A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection Completed NCT02476357 Phase 4
7 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4 Penicillin VK
8 Post-Operative Drainage Following Lymph Node Dissection Completed NCT00324272 Phase 4 Fibrin Sealant (Tisseel) used in the Experimental Arm.
9 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
10 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4 400 μg/kg Ivermectin + 400 mg Albendazole
11 Lower-Limb Drainage Mapping in Pelvic Lymphadenectomy for Gynaecological Cancer Active, not recruiting NCT01946672 Phase 4
12 Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity Terminated NCT01255631 Phase 4
13 Flexitouch Compression System for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
14 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
15 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
16 Prevention of Pelvic Lymphocele by Floseal During Pelvic Lymphadenectomy for Gynecologic Cancer Unknown status NCT01974193 Phase 3 Floseal
17 Randomized Trial of Exercise on Lower Extremity Edema After Lymphadenectomy in Gynecologic Cancer Unknown status NCT01849224 Phase 3
18 Lymphedema Upper Limb of Breast Cancer Through Muscle Strengthening Associated With Complex Physical Therapy Completed NCT02574780 Phase 2, Phase 3
19 Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva Completed NCT00028951 Phase 3 fibrin sealant
20 Trial of Decongestive Lymphatic Therapy for Lymphedema in Women With Breast Cancer "DELTA STUDY" Completed NCT00201890 Phase 3
21 Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer? Completed NCT00175344 Phase 3
22 Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes Completed NCT00287196 Phase 3
23 Effects of Aerobic Exercise Versus Weight Training in Breast Cancer Survivors During Chemotherapy Completed NCT00115713 Phase 3
24 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
25 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3 Ivermectin;Albendazole
26 Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema Recruiting NCT03210311 Phase 3
27 Preventive Intervention Against Lymphedema After Breast Cancer Surgery Recruiting NCT02518477 Phase 2, Phase 3
28 Conventional Versus Hypofractionated Radiotherapy in Node Positive Breast Cancer Recruiting NCT02690636 Phase 3
29 Breast Cancer Rehabilitation With Acupuncture and Physical Therapy Protocol Recruiting NCT02798263 Phase 2, Phase 3
30 Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma Recruiting NCT02166788 Phase 3
31 MIRs03: Paravertebral Block With Ropivacaine Before Breast Cancer Surgery Recruiting NCT02408393 Phase 3 Saline;Ropivacaine
32 Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Active, not recruiting NCT00376597 Phase 3
33 WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Active, not recruiting NCT01659437 Phase 2, Phase 3 Clarithromycin Extended Release;Streptomycin intramuscular injection
34 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3 Doxycycline;Placebo
35 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
36 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Not yet recruiting NCT02929134 Phase 3 Doxycycline;Placebo
37 Effects of an e-Home Based Symptom Management and Mindfulness Training Programme on QoL in Breast Cancer Survivors Not yet recruiting NCT02931864 Phase 3
38 Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer Terminated NCT00577317 Phase 3
39 Treatment of Lymphedema: Application of the Kinesio Taping Unknown status NCT00155220 Phase 2
40 Hyperbaric Oxygen Therapy Compared With Standard Therapy in Treating Chronic Arm Lymphedema in Patients Who Have Undergone Radiation Therapy for Cancer Unknown status NCT00077090 Phase 2 hyperbaric oxygen
41 Therapeutical Assessment of Compression Armsleeves for Lymphatic Indications Unknown status NCT01318785 Phase 2
42 Breast Lymph Node Mapping Unknown status NCT01038908 Phase 2
43 Pycnogenol for the Treatment of Lymphedema Completed NCT00214032 Phase 2 Pycnogenol;Placebo
44 Acupuncture for the Treatment of Chronic Lymphedema Completed NCT01003951 Phase 2
45 Horse Chestnut Seed Extract for Lymphedema Completed NCT00213928 Phase 2 Horse Chestnut Seed Extract
46 The Effect of Combined Decongestive Therapy and Pneumatic Compression Pump on Body Image in Patients With Lymphedema Completed NCT02650297 Phase 1, Phase 2
47 A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer Completed NCT00827372 Phase 2 Pazopanib
48 Use of Stem Cells in Lymphedema Post Mastectomy Completed NCT01112189 Phase 1, Phase 2
49 The Use of Selenium to Treat Secondary Lymphedema - Breast Cancer Completed NCT00188604 Phase 2 sodium selenite
50 Pycnogenol for the Treatment of Lymphedema of the Arm in Breast Cancer Survivors Completed NCT00064857 Phase 2 Pycnogenol

Search NIH Clinical Center for Lymphedema

Cochrane evidence based reviews: lymphedema

Genetic Tests for Lymphedema

Genetic tests related to Lymphedema:

id Genetic test Affiliating Genes
1 Lymphedema 29

Anatomical Context for Lymphedema

MalaCards organs/tissues related to Lymphedema:

39
Breast, Lymph Node, Skin, Endothelial, Testes, Liver, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Lymphedema:
id Tissue Anatomical CompartmentCell Relevance
1 Heart Cardinal Veins Venous Endothelial Cells Potential therapeutic candidate, affected by disease

Publications for Lymphedema

Articles related to Lymphedema:

(show top 50) (show all 905)
id Title Authors Year
1
Primary cutaneous anaplastic large cell lymphoma with intralymphatic involvement associated with chronic lymphedema. ( 28337783 )
2017
2
Near-Infrared Fluorescence Lymphatic Imaging of a Toddler With Congenital Lymphedema. ( 28356336 )
2017
3
Interosseous Membrane Release for Long-Standing Upper Limb Lymphedema: A Procedure Often Neglected. ( 28894671 )
2017
4
Volume and Tissue Composition Changes Measured with Dual-Energy X-Ray Absorptiometry in Melanoma-Related Limb Lymphedema. ( 28885862 )
2017
5
Lymphatic mapping of the upper limb with lymphedema before lymphatic supermicrosurgery by mirroring of the healthy limb. ( 28952193 )
2017
6
Far infrared ray (FIR) therapy: An effective and oncological safe treatment modality for breast cancer related lymphedema. ( 28535427 )
2017
7
Diagnostic Methods, Risk Factors, Prevention, and Management of Breast Cancer-Related Lymphedema: Past, Present, and Future Directions. ( 28894513 )
2017
8
"Vectra 3D Imaging for Quantitative Volumetric Analysis of the Upper Limb: A Feasibility Study for Tracking Outcomes of Lymphedema Treatment". ( 28922322 )
2017
9
Clinical Treatment of Penile Fibrosis After Penoscrotal Lymphedema. ( 28083477 )
2017
10
Renal anomalies and lymphedema distichiasis syndrome. A rare association? ( 28544699 )
2017
11
Hereditary Lymphedema of the Leg - A Case Report. ( 28785330 )
2017
12
T-regulatory cells mediate local immunosuppression in lymphedema. ( 28942366 )
2017
13
Translation and Validation of the Turkish Version of Lymphedema Quality of Life Tool (LYMQOL) in Patients with Breast Cancer Related Lymphedema. ( 28894851 )
2017
14
Effectiveness of acupuncture for breast cancer related lymphedema: protocol for a single-blind, sham-controlled, randomized, multicenter trial. ( 28934950 )
2017
15
Reply to: Precautionary Behaviors and Breast Cancer-Related Lymphedema. ( 28880728 )
2017
16
Establishment of an Acquired Lymphedema Model in the Mouse Hindlimb: Technical Refinement and Molecular Characteristics. ( 28027235 )
2017
17
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
18
Precautionary Behaviors and Breast Cancer-Related Lymphedema. ( 28880734 )
2017
19
Lymphedema of the Lower Extremities due to Refractory Malignant Lymphoma Treated by Lymphaticovenous Anastomosis. ( 28894674 )
2017
20
Breast angiosarcoma without radiation history, putatively associated with subclinical lymphedema: A case report and review of the Japanese literature. ( 28543441 )
2017
21
Surgical treatment of secondary lymphedema of the upper limb by stepped microsurgical lymphaticovenous anastomoses. ( 28083821 )
2017
22
Effects of Aqua-Lymphatic Therapy on Lower Extremity Lymphedema: A Randomized Controlled Study. ( 28880750 )
2017
23
Effects of a complex rehabilitation program on edema status, physical function, and quality of life in lower-limb lymphedema after gynecological cancer surgery. ( 28941657 )
2017
24
Tissue dielectric constant and circumference measurement in the follow-up of treatment related changes in lower limb lymphedema. ( 28945059 )
2017
25
Strategic recruitment of an ethnically diverse cohort of overweight survivors of breast cancer with lymphedema. ( 28881471 )
2017
26
Cutaneous polyarteritis nodosa localized to a region of lymphedema secondary to Streptococcus viridans cellulitis and multiple surgeries. ( 27862152 )
2017
27
Vulvar lymphedema and refractory VIN-III heralding GATA2 deficiency syndrome. ( 28947108 )
2017
28
Differentiation of functional venous insufficiency and leg lymphedema complicated by functional venous insufficiency using subcutaneous tissue ultrasonography. ( 27987622 )
2017
29
Supermicrosurgical lymphaticovenous anastomosis for a patient with breast lymphedema secondary to breast cancer treatment. ( 28052379 )
2017
30
Reference Ranges Using Bioimpedance for Detection of Lymphedema in Chinese Women. ( 28880731 )
2017
31
Surgical Treatment of Primary Lymphedema. ( 28880720 )
2017
32
Kaposi sarcoma: An unconventional cause of lower extremity lymphedema. ( 28875759 )
2017
33
The application of negative pressure wound therapy combined with compression bandaging for the decubitus ulcer of an advanced primary lower limb lymphedema. ( 28244063 )
2017
34
Therapeutic effects of hyaluronidase on acquired lymphedema using a newly developed mouse limb model. ( 28092183 )
2017
35
Serum Immune Proteins in Limb Lymphedema Reflecting Tissue Processes Caused by Lymph Stasis and Chronic Dermato-lymphangio-adenitis (Cellulitis). ( 28880710 )
2017
36
MYC amplification in angiosarcomas arising in the setting of chronic lymphedema of morbid obesity. ( 27686553 )
2017
37
CCBE1 Mutation causing Sclerosing Cholangitis - Expanding the Spectrum of Lymphedema-Cholestasis Syndrome. ( 28073151 )
2017
38
Platysma-sparing vascularized submental lymph node flap transfer for extremity lymphedema. ( 28058777 )
2017
39
Beckwith-Wiedemann Syndrome and Primary Lymphedema of the Lower Extremity. ( 27778389 )
2017
40
Pediatric genital lymphedema with recurrent hydrocele and late-onset secondary skin changes. ( 27978613 )
2017
41
Computed tomography-based quantitative assessment of lower extremity lymphedema following treatment for gynecologic cancer. ( 28028991 )
2016
42
Massive localized lymphedema of the thigh mimicking liposarcoma. ( 27920868 )
2016
43
A Detailed Examination of the Characteristics and Treatment in a Series of 33 Idiopathic Lymphedema Patients. ( 27542110 )
2016
44
Ocular manifestations of microcephaly with or without chorioretinopathy, lymphedema or intellectual disability (MCLID) syndrome associated with mutations in KIF11. ( 25996076 )
2016
45
Time to Re-consider a Gold Standard of Lymph Flow Imaging: Importance of Reliability to Detect Abnormal Lymphodynamics in Lymphedema Screening after Cancer Treatments. ( 28002242 )
2016
46
The Impact of L-Dex(Ar) Measurements in Assessing Breast Cancer-Related Lymphedema as Part of Routine Clinical Practice. ( 27656420 )
2016
47
Are compression corsets beneficial for the treatment of breast cancer-related lymphedema? New opportunities in physiotherapy treatment - a preliminary report. ( 27103835 )
2016
48
Effect of complete decongestive therapy and home program on health- related quality of life in post mastectomy lymphedema patients. ( 27145867 )
2016
49
Chronic Localized Fibrosing Leukocytoclastic Vasculitis Associated With Lymphedema, Intralymphatic and Intravascular Lymphocytosis, and Chronic Myelogenous Leukemia: A Case Report of Unilateral Erythema Elevatum Diutinum. ( 27930381 )
2016
50
Integration-free T cell-derived human induced pluripotent stem cells (iPSCs) from a patient with lymphedema-distichiasis syndrome (LDS) carrying an insertion-deletion complex mutation in the FOXC2 gene. ( 27346194 )
2016

Variations for Lymphedema

Expression for Lymphedema

Search GEO for disease gene expression data for Lymphedema.

Pathways for Lymphedema

GO Terms for Lymphedema

Biological processes related to Lymphedema according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.8 FLT4 KDR NRP2 SOX18 VEGFC
2 positive regulation of angiogenesis GO:0045766 9.76 CCBE1 GATA2 KDR VEGFC
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.72 FLT4 FOXC2 KDR NRP2 VEGFC
4 kidney development GO:0001822 9.71 FAT4 FOXC2 PROX1
5 positive regulation of endothelial cell proliferation GO:0001938 9.65 FLT4 KDR NRP2 PROX1 VEGFC
6 positive regulation of endothelial cell migration GO:0010595 9.63 CCBE1 FLT4 FOXC2 KDR NRP2 PROX1
7 positive regulation of macroautophagy GO:0016239 9.61 IKBKG KDR
8 positive regulation of vascular endothelial growth factor production GO:0010575 9.61 CCBE1 FLT4
9 sprouting angiogenesis GO:0002040 9.6 CCBE1 FLT4
10 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.59 FOXC2 PROX1
11 vasculature development GO:0001944 9.58 FLT4 SOX18
12 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 FLT4 KDR
13 embryonic heart tube development GO:0035050 9.57 FOXC2 SOX18
14 cell fate determination GO:0001709 9.55 GATA2 PROX1
15 vascular endothelial growth factor signaling pathway GO:0038084 9.54 FLT4 KDR NRP2
16 respiratory system process GO:0003016 9.52 CCBE1 FLT4
17 venous blood vessel morphogenesis GO:0048845 9.51 CCBE1 PROX1
18 lymphatic endothelial cell differentiation GO:0060836 9.49 PROX1 SOX18
19 endocardium formation GO:0060214 9.48 PROX1 SOX18
20 positive regulation of lymphangiogenesis GO:1901492 9.43 CCBE1 VEGFC
21 lymph vessel development GO:0001945 9.35 CCBE1 FLT4 FOXC2 PROX1 SOX18
22 lymphangiogenesis GO:0001946 9.1 CCBE1 FLT4 FOXC2 PROX1 PTPN14 SOX18
23 multicellular organism development GO:0007275 10.03 CCBE1 FOXC2 KDR NRP2 PROX1 VEGFC

Molecular functions related to Lymphedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 9.13 FLT4 KDR NRP2
2 vascular endothelial growth factor-activated receptor activity GO:0005021 8.8 FLT4 KDR NRP2

Sources for Lymphedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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