MCID: LYM025
MIFTS: 56

Lymphedema malady

Cardiovascular diseases, Immune diseases categories

Summaries for Lymphedema

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Lymphedema is the name of a type of swelling. it happens when lymph builds up in your body's soft tissues. lymph is a fluid that contains white blood cells that defend against germs. it can build up when the lymph system is damaged or blocked. it usually happens in the arms or legs. causes of lymphedema include infection cancer scar tissue from radiation therapy or surgical removal of lymph nodes inherited conditions in which lymph nodes or vessels are absent or abnormal treatment can help control symptoms. it includes exercise, compression devices, skin care, and massage. nih: national cancer institute

MalaCards: Lymphedema, also known as lymphedema, acquired, is related to breast cancer and lymphedema-distichiasis syndrome. An important gene associated with Lymphedema is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are p70S6K Signaling and Heart Development. The compound vegf have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and skin, and related mouse phenotypes are pigmentation and normal.

CDC:3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

Wikipedia:63 Lymphedema (lymphoedema in British English), also known as lymphatic obstruction, is a condition of... more...

Aliases & Classifications for Lymphedema

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Immune diseases


Aliases & Descriptions:

lymphedema 8 10 44 33 60
lymphedema, acquired 8
lymphatic edema 8
lymphoedema nos 8
lymphoedema 8


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Disease Ontology8 DOID:4977
NCIt39 C3207
MeSH34 D008209
ICD1025 I89.0

Related Diseases for Lymphedema

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Lymphedema family:

Lymphedema, Congenital Congenital Primary Lymphedema

Diseases related to Lymphedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer31.2SOX18, FOXC1, GATA2, FLT4, PROX1, VEGFC
2lymphedema-distichiasis syndrome30.9FOXC2
3lymphangiosarcoma30.9PROX1
4yellow nail syndrome30.6SOX18
5angiosarcoma30.4PDPN, FLT4, VEGFC
6lymphedema, congenital30.3FIGF, VEGFC, FOXC2, PDPN, FLT4
7mongolian spot30.1FOXC2, SOX18
8hypotrichosis30.1SOX18
9sarcoma30.0FLT4
10squamous cell carcinoma29.9OXA1L, PDPN, FLT4, VEGFC, FIGF
11klippel-trenaunay syndrome29.7FOXC2, SOX18, FLT4
12inflammatory breast carcinoma29.7VEGFC, FIGF, PROX1
13kaposi's sarcoma29.7VEGFC, FLT4, PDPN
14prostate cancer29.7VEGFC, FLT4, PDPN, FIGF, OXA1L
15hereditary lymphedema10.7
16hereditary lymphedema type ii10.4
17elephantiasis10.4
18meige lymphedema10.4
19hennekam syndrome10.3
20aagenaes syndrome10.3
21hypotrichosis-lymphedema-telangiectasia syndrome10.3
22erysipelas10.2
23microcephaly10.2
24obesity10.2
25breast reconstruction10.2
26filariasis10.2
27microcephaly with or without chorioretinopathy, lymphedema, or mental retardation10.2
28lymphedema and cerebral arteriovenous anomaly10.2
29lymphangitis10.1
30chorioretinitis10.1
31melanoma10.1
32lymphedema, microcephaly and chorioretinopathy syndrome10.1
33hereditary lymphedema ic10.1
34arthritis10.1
35tuberous sclerosis10.1
36filarial elephantiasis10.1
37cervical cancer10.1
38cervicitis10.1
39lymph node cancer10.1
40turner syndrome10.1
41dahlberg borer newcomer syndrome10.1
42lymphedema - atrial septal defects - facial changes10.1
43lymphangioleiomyomatosis10.0
44noonan syndrome10.0
45arachnoiditis10.0
46protein-losing enteropathy10.0
47podoconiosis10.0
48lymphedema, primary, with myelodysplasia10.0
49ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency10.0
50congenital primary lymphedema10.0

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to lymphedema

Clinical Features for Lymphedema

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Drugs & Therapeutics for Lymphedema

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lymphedema

Drug clinical trials:

Search ClinicalTrials for Lymphedema

Search NIH Clinical Center for Lymphedema

Search CenterWatch for Lymphedema

Genetic Tests for Lymphedema

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Anatomical Context for Lymphedema

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Lymphedema:

32
Breast, Lymph node, Skin, Endothelial, Bone, Prostate, Colon, B cells, T cells, Monocytes, Myeloid, Brain, Nk cells, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Lymphedema:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Potential therapeutic candidate, affected by disease

Animal Models for Lymphedema or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphedema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000118610.4FOXC2, SOX18
2MP:000287310.2CCBE1, SOX18, FOXC2, FOXC1, GATA2, FLT4
3MP:000537010.1CCBE1, FOXC2, FOXC1, GATA2, FLT4, PROX1
4MP:000538510.1SOX18, PDPN, FOXC2, FOXC1, GATA2, FLT4
5MP:000538710.1FOXC2, PDPN, SOX18, CCBE1, FLT4, PROX1
6MP:000537810.0FOXL1, FOXC1, FOXC2, PDPN, SOX18, GATA2
7MP:000538110.0PDPN, FOXC2, FOXC1, FOXL1, FLT4, PROX1
8MP:001076810.0KIF11, CCBE1, SOX18, PDPN, FOXC2, FOXC1
9MP:00053769.9FOXC1, FOXC2, PDPN, SOX18, CCBE1, GATA2
10MP:00053759.9FOXC2, FLT4, PROX1, FIGF, IKBKG

Publications for Lymphedema

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50PubMed
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Articles related to Lymphedema:

(show top 50)    (show all 685)
idTitleAuthorsYear
1
Massive localized lymphedema, a disease unique to the morbidly obese: a case study. (24434164)
2014
2
Influence of weight training on skeletal health of breast cancer survivors with or at risk for breast cancer-related lymphedema. (24390808)
2014
3
A novel complex insertion-deletion mutation in the FOXC2 gene in a Japanese patient with Lymphedema-Distichiasis Syndrome. (23747797)
2013
4
Massive localized lymphedema of the male external genitalia: a clinicopathologic study of 6 cases. (22995331)
2013
5
Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. (24163130)
2013
6
Lymphedema in a patient with distichiasis. (24215208)
2013
7
Th2 differentiation is necessary for soft tissue fibrosis and lymphatic dysfunction resulting from lymphedema. (23193171)
2013
8
Isolated primary lymphedema tarda of the upper limb. (23531184)
2013
9
Four generations of rare familial lymphedema (Milroy disease). (23751338)
2013
10
Vascularized supraclavicular lymph node transfer for lower extremity lymphedema treatment. (23271547)
2013
11
What is your diagnosis? Chronic progressive lymphedema (CPL). (23327171)
2013
12
Significance of popliteal lymph nodes visualization during radionuclide lymphoscintigraphy for lower limb lymphedema. (24250020)
2013
13
Cutaneous epithelioid clear cells angiosarcoma in a young woman with congenital lymphedema. (24078891)
2013
14
Lymphedema microsurgical preventive healing approach for primary prevention of lower limb lymphedema after inguinofemoral lymphadenectomy for vulvar cancer. (23485932)
2013
15
Developing a breast cancer-related lymphedema program: the William Beaumont Hospital experience. (23301763)
2013
16
Information for patients with or at risk of cancer-related lymphedema. (24080052)
2013
17
Primary congenital lymphedema complicated by hydrops fetalis: a case report and review of the literature. (23533860)
2013
18
Psychosocial impact of living with cancer-related lymphedema. (23375066)
2013
19
Yellow nail syndrome: treatment of lymphedema using low pressure compression. (22416910)
2012
20
Complex Decongestive Physiotherapy Treats Skin Changes like Hyperkeratosis Caused by Lymphedema. (23259083)
2012
21
Scale-independent stiffness measurement of upper limbs with lymphedema by a circular compression. (23366313)
2012
22
Angiosarcoma on the lower abdominal wall associated with chronic lymphedema in an obese woman. (23171024)
2012
23
Transnodal lymphangiography in the diagnosis and treatment of genital lymphedema. (22864605)
2012
24
Incidence and risk factors of lower-extremity lymphedema after radical surgery with or without adjuvant radiotherapy in patients with FIGO stage I to stage IIA cervical cancer. (22398707)
2012
25
Acute lymphedema of the eyelid after major reconstruction of the medial canthus: the role of the lymphatic drainage pattern. (21921751)
2011
26
Appearance of retroperitoneal lymphedema on CT scan after penetrating neck injury. (21679658)
2011
27
Lymphedema in a Guyanan migrant. (21199149)
2011
28
Reliability and concurrent validity of the perometer for measuring hand volume in women with and without lymphedema. (21417763)
2011
29
Comparison of diagnostic accuracy of clinical measures of breast cancer-related lymphedema: area under the curve. (21440706)
2011
30
Assessment of lymphedema by bioelectrical impedance spectroscopy. (21615703)
2011
31
Prospective, randomized, controlled trial comparing a new two-component compression system with inelastic multicomponent compression bandages in the treatment of leg lymphedema. (21575097)
2011
32
Assessment of quality of life in lymphedema patients: validity and reliability of the Swedish version of the Lymphedema Quality of Life Inventory (LQOLI). (21226416)
2010
33
Efficient selection of association rules from lymphedema symptoms data using a graph structure. (21347111)
2010
34
Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema. (21258451)
2010
35
HGF and MET mutations in primary and secondary lymphedema. (18564920)
2008
36
Novel FOXC2 missense mutation identified in patient with lymphedema-distichiasis syndrome and review. (19013876)
2008
37
Wide clinical spectrum in a family with hereditary lymphedema type I due to a novel missense mutation in VEGFR3. (16924388)
2006
38
De novo CD5-positive diffuse large B-cell lymphoma of the skin arising in chronic limb lymphedema. (16019518)
2005
39
Hydrops fetalis: an unusual prenatal presentation of hereditary congenital lymphedema. (16231305)
2005
40
Quantification of lymphatic function for investigation of lymphedema: depot clearance and rate of appearance of soluble macromolecules in blood. (11884490)
2002
41
Multiple effusions and lymphedema in the yellow nail syndrome. (11805000)
2002
42
Microcephaly-lymphedema-chorioretinal dysplasia: a unique genetic syndrome with variable expression and possible characteristic facial appearance. (10482868)
1999
43
Localization of dermal edema in lipodermatosclerosis, lymphedema, and cardiac insufficiency. High-frequency ultrasound examination of intradermal echogenicity. (8682961)
1996
44
Lymphangiosarcoma in late-onset hereditary lymphedema: case report and nosological implications. (7747790)
1995
45
Hereditary lymphedema and distichiasis. (2064580)
1991
46
Congenital hereditary lymphedema (Nonne/Milroy). (2616174)
1989
47
Lymphangiosarcoma in chronic lymphedema that followed dissection of the groin in surgical management of a malignant melanoma. (6528924)
1984
48
Lymphangiosarcoma and congenital lymphedema of the extremity. (4414532)
1974
49
Lymphangiosarcoma in postmastectomy lymphedema. (5866201)
1965
50
Lymphangiosarcoma in post-mastectomy lymphedema; a case report. (14866703)
1951

Genetic Variations for Lymphedema

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Expression for genes affiliated with Lymphedema

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphedema

Search GEO for disease gene expression data for Lymphedema.

Pathways for genes affiliated with Lymphedema

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51QIAGEN, 37NCBI BioSystems Database, 49PharmGKB, 55SinoBiological, 12EMD Millipore, 53Reactome, 29KEGG
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Compounds for genes affiliated with Lymphedema

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44Novoseek
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Compounds related to Lymphedema according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vegf4410.2FIGF, VEGFC, PROX1, FLT4, PDPN

GO Terms for genes affiliated with Lymphedema

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16Gene Ontology
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Cellular components related to Lymphedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.9PTPN14, SOX18, FOXC2, FOXC1, FOXL1, GATA2

Biological processes related to Lymphedema according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1embryonic heart tube developmentGO:03505010.7FOXC1, FOXC2, SOX18
2positive regulation of mast cell chemotaxisGO:06075410.7VEGFC, FIGF
3endocardium formationGO:06021410.7SOX18, PROX1
4venous blood vessel morphogenesisGO:04884510.7PROX1, CCBE1
5lymph vessel developmentGO:00194510.7FLT4, FOXC1
6positive regulation of endothelial cell migrationGO:01059510.7PROX1, FLT4, FOXC2
7lymphatic endothelial cell differentiationGO:06083610.7PROX1, SOX18
8camera-type eye developmentGO:04301010.7FOXL1, FOXC1, FOXC2
9ventricular cardiac muscle tissue morphogenesisGO:05501010.7FOXC2, FOXC1, PROX1
10regulation of organ growthGO:04662010.6FOXC2, FOXC1
11cardiac muscle cell proliferationGO:06003810.6FOXC2, FOXC1
12regulation of blood vessel sizeGO:05088010.6FOXC2, FOXC1
13vascular endothelial growth factor receptor signaling pathwayGO:04801010.6FOXC2, FOXC1, FLT4, VEGFC, FIGF
14induction of positive chemotaxisGO:05093010.5VEGFC, FIGF
15neural crest cell developmentGO:01403210.5FOXC2, FOXC1
16embryo developmentGO:00979010.5FOXL1, FOXC1, PDPN
17lymphangiogenesisGO:00194610.5PTPN14, PROX1, FLT4, FOXC2, PDPN, SOX18
18negative regulation of transcription from RNA polymerase II promoterGO:00012210.5PROX1, GATA2, FOXC1, FOXC2, SOX18
19sprouting angiogenesisGO:00204010.5FLT4, CCBE1
20artery morphogenesisGO:04884410.4FOXC2, FOXC1
21positive regulation of transcription from RNA polymerase II promoterGO:04594410.4SOX18, FOXC2, FOXC1, GATA2, IKBKG
22heart developmentGO:00750710.3FOXL1, FOXC1, FOXC2
23vasculature developmentGO:00194410.3FLT4, SOX18
24tissue developmentGO:00988810.1FOXL1, FOXC1

Molecular functions related to Lymphedema according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor 3 bindingGO:04318510.5FIGF, VEGFC
2DNA binding, bendingGO:00830110.4FOXL1, FOXC1, FOXC2
3transcription regulatory region DNA bindingGO:04421210.4SOX18, FOXC2, FOXC1, PROX1
4chemoattractant activityGO:04205610.4FIGF, VEGFC
5RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:00107710.3SOX18, FOXC2, GATA2
6sequence-specific DNA binding transcription factor activityGO:00370010.1FOXC2, FOXC1, FOXL1, GATA2, PROX1, SHOX
7RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.0PROX1, FOXC1, FOXC2

Products for genes affiliated with Lymphedema

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Sources for Lymphedema

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet