MCID: LYM025
MIFTS: 53

Lymphedema malady

Genetic diseases, Cardiovascular diseases, Immune diseases, Rare diseases, Eye diseases, Skin diseases categories
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Summaries for Lymphedema

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35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Lymphedema is the name of a type of swelling. it happens when lymph builds up in your body's soft tissues. lymph is a fluid that contains white blood cells that defend against germs. it can build up when the lymph system is damaged or blocked. it usually happens in the arms or legs. causes of lymphedema include infection cancer scar tissue from radiation therapy or surgical removal of lymph nodes inherited conditions in which lymph nodes or vessels are absent or abnormal treatment can help control symptoms. it includes exercise, compression devices, skin care, and massage. nih: national cancer institute

MalaCards: Lymphedema, also known as lymphedema, acquired, is related to angiosarcoma and lymphedema, congenital. An important gene associated with Lymphedema is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Angiogenesis and VEGF Pathway. Affiliated tissues include breast, lymph node and skin, and related mouse phenotypes are cardiovascular system and normal.

CDC:4 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

Wikipedia:66 Lymphedema (lymphoedema or lymph?dema in British English), also known as lymphatic obstruction, is a... more...

Aliases & Classifications for Lymphedema

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
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Global: Genetic diseases, Rare diseases
Anatomical: Cardiovascular diseases, Immune diseases, Eye diseases, Skin diseases


Aliases & Descriptions:

lymphedema 9 11 46 35 63
lymphedema, acquired 9
lymphoedema nos 9
lymphatic edema 9
lymphoedema 9


External Ids:

Disease Ontology9 DOID:4977
MeSH36 D008209
NCIt41 C3207
ICD1026 I89.0

Related Diseases for Lymphedema

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Hereditary Lymphedema family:

lymphedema Hereditary Lymphedema Type Ii
Lymphedema, Congenital Hereditary Lymphedema Ic
Lymphedema, Hereditary, Ib

Diseases related to Lymphedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1angiosarcoma30.5FLT4, VEGFC
2lymphedema, congenital30.4VEGFC, FLT4, FOXC2
3hydrops fetalis30.4FLT4
4mongolian spot30.3FOXC2, SOX18
5klippel-trenaunay syndrome29.8SOX18, FLT4, FOXC2
6kaposi's sarcoma29.8VEGFC, FLT4
7breast cancer10.9
8hereditary lymphedema10.7
9lymphedema-distichiasis syndrome10.7
10lymphangiosarcoma10.6
11hereditary lymphedema type ii10.6
12yellow nail syndrome10.5
13hennekam syndrome10.5
14elephantiasis10.4
15aagenaes syndrome10.4
16hypotrichosis-lymphedema-telangiectasia syndrome10.4
17lipedema10.3
18microcephaly10.3
19erysipelas10.3
20obesity10.3
21breast reconstruction10.3
22filariasis10.3
23hereditary lymphedema ic10.3
24microcephaly with or without chorioretinopathy, lymphedema, or mental retardation10.3
25chylous ascites10.2
26lymphedema and cerebral arteriovenous anomaly10.2
27lymphangitis10.2
28chorioretinitis10.2
29melanoma10.2
30lymphedema, microcephaly and chorioretinopathy syndrome10.2
31arthritis10.1
32tuberous sclerosis10.1
33cervical cancer10.1
34cervicitis10.1
35turner syndrome10.1
36dahlberg borer newcomer syndrome10.1
37mental retardation10.1
38lymphedema - atrial septal defects - facial changes10.1
39protein-losing enteropathy10.1
40podoconiosis10.1
41lymphangioleiomyomatosis10.1
42noonan syndrome10.1
43arachnoiditis10.1
44hypotrichosis10.1
45sarcoma10.1
46arachnoid cysts10.1
47lymphedema, primary, with myelodysplasia10.1
48choanal atresia and lymphedema10.1
49emberger syndrome10.1
50ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency10.1

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to lymphedema

Symptoms for Lymphedema

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Drugs & Therapeutics for Lymphedema

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Sources:
43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lymphedema

Search NIH Clinical Center for Lymphedema

Genetic Tests for Lymphedema

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Anatomical Context for Lymphedema

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32LifeMap Discovery™, 34MalaCards
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MalaCards organs/tissues related to Lymphedema:

34
Breast, Lymph node, Skin, Endothelial, Bone, B cells, T cells, Nk cells, Monocytes, Myeloid, Prostate, Colon, Brain, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Lymphedema:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Potential therapeutic candidate, affected by disease

Animal Models for Lymphedema or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lymphedema:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4FOXC2, VEGFC, SOX18, FLT4
2MP:00028738.2GJC2, SOX18, FLT4, FOXC2, CCBE1
3MP:00053788.0KIF11, FOXC2, FLT4, SOX18, PTPN14
4MP:00053767.4FOXC2, VEGFC, PTPN14, SOX18, FLT4, CCBE1
5MP:00053877.0VEGFC, PTPN14, SOX18, FLT4, FOXC2, CCBE1
6MP:00107686.9GJC2, VEGFC, SOX18, FLT4, FOXC2, CCBE1

Publications for Lymphedema

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53PubMed
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Articles related to Lymphedema:

(show top 50)    (show all 678)
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idTitleAuthorsYear
1
Malpractice leading to secondary lymphedema after radical mastectomy: case report. (24415992)
2013
2
A novel complex insertion-deletion mutation in the FOXC2 gene in a Japanese patient with Lymphedema-Distichiasis Syndrome. (23747797)
2013
3
Complete decongestive therapy for treatment of lymphedema. (23375063)
2013
4
Penile and sexual rehabilitation in a patient with lymphedema of the penis. (23485846)
2013
5
Axillary reverse mapping using fluorescence imaging is useful for identifying the risk group of postoperative lymphedema in breast cancer patients undergoing sentinel node biopsies. (24310418)
2013
6
Massive localized lymphedema of the male external genitalia: a clinicopathologic study of 6 cases. (22995331)
2013
7
The effects of pole walking on arm lymphedema and cardiovascular fitness in women treated for breast cancer: a pilot and feasibility study. (24175620)
2013
8
Eyelid lymphedema following neck dissection and radiotherapy. (23446298)
2013
9
Therapeutic strategy for lower limb lymphedema and lymphatic fistula after resection of a malignant tumor in the hip joint region: A case report. (23908155)
2013
10
Optimizing surgical treatment of lymphedema. (23246031)
2013
11
Re-evaluation of qualitative lymphangioscintigraphic findings in secondary lower extremity lymphedema. (24374366)
2013
12
Congenital Segmental Lymphedema in Tuberous Sclerosis Complex With Associated Subependymal Giant Cell Astrocytomas Treated with Mammalian Target of Rapamycin Inhibitors. (24056156)
2013
13
Peripheral venous angle plasty: a new lymphovenous anastomosis technique for lower extremity lymphedema. (22743945)
2012
14
Axillary reverse mapping (ARM): initial results of phase II trial in preventing lymphedema after lymphadenectomy. (23018481)
2012
15
Neutrophilic dermatosis on postmastectomy lymphedema. (22677124)
2012
16
Liposuction normalizes - in contrast to other therapies - lymphedema-induced adipose tissue hypertrophy. (23283813)
2012
17
Localized xanthomas associated with primary lymphedema. (22256994)
2012
18
Voices from the shadows: living with lymphedema. (21558848)
2012
19
Yellow nail syndrome: treatment of lymphedema using low pressure compression. (22416910)
2012
20
Antegrade and retrograde lymphatico-venous anastomosis for cancer-related lymphedema with lymphatic valve dysfuction and lymphatic varix. (22903404)
2012
21
Congenital chylous ascites and lymphedema in Down's syndrome. (22418947)
2012
22
Current views on diagnostic approach and treatment of lymphedema. (22269614)
2012
23
Complex Decongestive Physiotherapy Treats Skin Changes like Hyperkeratosis Caused by Lymphedema. (23259083)
2012
24
Scale-independent stiffness measurement of upper limbs with lymphedema by a circular compression. (23366313)
2012
25
Quantification of lymphedema in a rat model by 3D-active contour segmentation by magnetic resonance imaging. (22416909)
2012
26
Prenatal diagnosis of Milroy's primary congenital lymphedema. (22795109)
2012
27
Lymphaticovenular anastomoses for lymphedema treatment: 18 months postoperative outcomes. (22262630)
2012
28
Nursing education on lymphedema self-management and self-monitoring in a South African oncology clinic. (22288209)
2011
29
Prediction of treatment outcome with bioimpedance measurements in breast cancer related lymphedema patients. (22506192)
2011
30
Gene expression in Graves' ophthalmopathy and arm lymphedema: similarities and differences. (21510802)
2011
31
Surgical management of lymphedema: past, present, and future. (22066746)
2011
32
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
33
Giant scrotal lymphedema as unique onset sign of muscle-invasive bladder cancer. The risk of a misdiagnosis. (21826882)
2011
34
Lymphedema in patients with head and neck cancer. (21186146)
2011
35
Tissue fluid pressure and flow during pneumatic compression in lymphedema of lower limbs. (21688976)
2011
36
Impact of aggressive decongestion on the maintenance phase in combined physical therapy for lower extremity lymphedema. (23555469)
2011
37
Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial. (21148134)
2010
38
Rare association of immunoglobulin A nephropathy and lymphedema-distichiasis syndrome. (20124880)
2010
39
Cutaneous tumors, massive lymphadenopathy, and secondary lymphedema in a 16-year-old boy--quiz case. African/endemic Kaposi sarcoma (KS): lymphadenopathic form. (18794470)
2008
40
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
41
Stewart-Treves syndrome as a rare complication of a hereditary lymphedema. (15061047)
2004
42
Kaposiform hemangioendothelioma associated with Milroy's disease (primary hereditary lymphedema). (12861592)
2003
43
Quantification of lymphatic function for investigation of lymphedema: depot clearance and rate of appearance of soluble macromolecules in blood. (11884490)
2002
44
Lymphedema-lymphangiectasia-mental retardation (Hennekam) syndrome: a review. (12376947)
2002
45
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. (11175851)
2001
46
Lymphedema-distichiasis syndrome: report of a case and review. (10086462)
1999
47
Lymphangiosarcoma of arm after chronic lymphedema: a rare long-term complication after radical mastectomy in breast cancer patients. Case report and overview. (8503088)
1993
48
Hereditary lymphedema in Hereford cattle. (2039787)
1991
49
Congenital hereditary lymphedema in the pig. (642582)
1978
50
The pathogenesis of congenital hereditary lymphedema in the pig. (642583)
1978

Variations for Lymphedema

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Expression for genes affiliated with Lymphedema

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphedema

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Pathways for genes affiliated with Lymphedema

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51PathCards, 5Cell Signaling Technology, 62Tocris Bioscience, 54QIAGEN, 61Thomson Reuters, 56Reactome, 52PharmGKB, 58SinoBiological, 39NCBI BioSystems Database
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Compounds for genes affiliated with Lymphedema

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GO Terms for genes affiliated with Lymphedema

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17Gene Ontology
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Biological processes related to Lymphedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sprouting angiogenesisGO:0020409.7CCBE1, FLT4
2embryonic heart tube developmentGO:0350509.5FOXC2, SOX18
3vasculature developmentGO:0019449.5FLT4, SOX18
4positive regulation of endothelial cell migrationGO:0105959.2FLT4, FOXC2, CCBE1
5vascular endothelial growth factor receptor signaling pathwayGO:0480108.9FOXC2, FLT4, VEGFC
6lymphangiogenesisGO:0019468.5CCBE1, FOXC2, FLT4, SOX18, PTPN14

Molecular functions related to Lymphedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.6FOXC2, SOX18

Products for genes affiliated with Lymphedema

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  • Antibodies

Sources for Lymphedema

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet