MCID: LYM025
MIFTS: 63

Lymphedema

Categories: Rare diseases, Genetic diseases, Neuronal diseases, Reproductive diseases, Oral diseases, Immune diseases

Aliases & Classifications for Lymphedema

MalaCards integrated aliases for Lymphedema:

Name: Lymphedema 37 12 72 28 51 40 3 41 14 69
Lymphatic Edema 12
Lymphoedema Nos 12
Lymphedemas 36

Classifications:



External Ids:

Disease Ontology 12 DOID:4977
MeSH 41 D008209
NCIt 46 C3207
KEGG 36 H00535
UMLS 69 C0024236

Summaries for Lymphedema

MedlinePlus : 40 Lymphedema is the name of a type of swelling. It happens when lymph builds up in your body's soft tissues. Lymph is a fluid that contains white blood cells that defend against germs. It can build up when the lymph system is damaged or blocked. It usually happens in the arms or legs. Causes of lymphedema include Infection Cancer Scar tissue from radiation therapy or surgical removal of lymph nodes Inherited conditions in which lymph nodes or vessels are absent or abnormal Treatment can help control symptoms. It includes exercise, compression devices, skin care, and massage. NIH: National Cancer Institute

MalaCards based summary : Lymphedema, also known as lymphatic edema, is related to lymphedema, hereditary, ii and yellow nail syndrome, and has symptoms including peau d'orange, edema and chest pain. An important gene associated with Lymphedema is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are PAK Pathway and p70S6K Signaling. The drugs Penicillin V and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include Heart, lymph node and skin, and related phenotypes are cardiovascular system and growth/size/body region

CDC : 3 Lymphatic filariasis, considered globally as a neglected tropical disease , is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

Wikipedia : 72 Lymphedema, also known as lymphoedema and lymphatic edema, is a condition of localized fluid retention... more...

Related Diseases for Lymphedema

Diseases in the Lymphedema family:

Lymphedema, Hereditary, Ia Lymphedema, Hereditary, Ii
Lymphedema, Congenital Recessive Lymphedema, Hereditary, Ib
Lymphedema, Hereditary, Ic Lymphedema, Hereditary, Id
Lymphedema, Hereditary, Iii Hereditary Lymphedema
Congenital Lymphedema

Diseases related to Lymphedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 247)
# Related Disease Score Top Affiliating Genes
1 lymphedema, hereditary, ii 33.9 FOXC2 GJC2 SOX18
2 yellow nail syndrome 33.6 FOXC2 SOX18
3 hereditary lymphedema 33.1 FLT4 FOXC2 GJC2 HNRNPH1
4 congenital lymphedema 32.5 FLT4 FOXC2 HNRNPH1 KIF11 VEGFC
5 hennekam syndrome 32.2 CCBE1 FAT4 FLT4 PROX1 VEGFC
6 lymphangiosarcoma 32.1 FLT4 GJC2 PROX1 VEGFC
7 lymphatic system disease 31.0 FLT4 FOXC2 GJC2 VEGFC
8 cellulitis 29.8 FLT4 GJC2
9 klippel-trenaunay-weber syndrome 29.7 FLT4 FOXC2 SOX18
10 gorham's disease 29.7 FLT4 PROX1
11 immune hydrops fetalis 29.6 CCBE1 PIEZO1
12 hemangioendothelioma 29.6 FLT4 KDR
13 angiosarcoma 29.5 FLT4 KDR PROX1
14 kaposiform hemangioendothelioma 28.9 FLT4 KDR PROX1
15 hemangioma 28.9 FLT4 KDR PROX1
16 lymphedema-distichiasis syndrome 12.5
17 lymphedema, hereditary, ia 12.5
18 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 12.4
19 hypotrichosis-lymphedema-telangiectasia syndrome 12.4
20 cholestasis-lymphedema syndrome 12.3
21 choanal atresia and lymphedema 12.3
22 lymphedema, primary, with myelodysplasia 12.2
23 lymphedema, hereditary, iii 12.2
24 hennekam lymphangiectasia-lymphedema syndrome 1 12.2
25 lymphedema, hereditary, ic 12.2
26 hennekam lymphangiectasia-lymphedema syndrome 2 12.2
27 deafness-lymphedema-leukemia syndrome 12.2
28 ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema 12.2
29 lymphedema, hereditary, id 12.1
30 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 12.1
31 lymphedema, hereditary, ib 12.1
32 lymphedema, cardiac septal defects, and characteristic facies 12.0
33 agenesis of the corpus callosum and congenital lymphedema 11.9
34 lymphedema and cerebral arteriovenous anomaly 11.9
35 lymphedema-hypoparathyroidism syndrome 11.8
36 lymphedema, congenital recessive 11.8
37 dahlberg borer newcomer syndrome 11.5
38 takenouchi-kosaki syndrome 11.4
39 filarial elephantiasis 11.3
40 kaposi sarcoma 11.1
41 podoconiosis 11.1
42 immunodeficiency 21 11.1
43 turner syndrome 11.1
44 bier spots 11.1
45 irons bhan syndrome 10.9
46 microcephaly and chorioretinopathy, autosomal recessive, 1 10.8
47 oculodentodigital dysplasia 10.8
48 immunodeficiency 33 10.8
49 kanzaki disease 10.8
50 verruciform xanthoma of skin 10.8

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to Lymphedema

Symptoms & Phenotypes for Lymphedema

UMLS symptoms related to Lymphedema:


peau d'orange, edema, chest pain, angina pectoris

MGI Mouse Phenotypes related to Lymphedema:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 FAT4 FLT4 FOXC2 GATA2 IKBKG KDR
2 growth/size/body region MP:0005378 10.15 SOX18 PIEZO1 PROX1 PTPN14 KIF11 NRP2
3 homeostasis/metabolism MP:0005376 10.1 CCBE1 FLT4 FOXC2 GATA2 IKBKG KDR
4 immune system MP:0005387 10.03 VEGFC CCBE1 FLT4 FOXC2 GJC2 IKBKG
5 embryo MP:0005380 10.01 FAT4 FLT4 FOXC2 GATA2 KDR KIF11
6 digestive/alimentary MP:0005381 9.91 FAT4 FLT4 FOXC2 IKBKG PROX1 SOX18
7 mortality/aging MP:0010768 9.83 CCBE1 FAT4 FLT4 FOXC2 GATA2 GJC2
8 liver/biliary system MP:0005370 9.7 CCBE1 FLT4 FOXC2 GATA2 IKBKG KDR
9 normal MP:0002873 9.32 CCBE1 FLT4 FOXC2 GATA2 GJC2 IKBKG

Drugs & Therapeutics for Lymphedema

Drugs for Lymphedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
2
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54965-21-8 2082
3
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 70288-86-7 46936176 6474909
4
Azithromycin Approved Phase 4 83905-01-5 53477736 447043 55185
5 Radiopharmaceuticals Phase 4,Phase 2
6 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
7 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
9 penicillins Phase 4
10 Coagulants Phase 4,Phase 3
11 Fibrin Tissue Adhesive Phase 4,Phase 3
12 Hemostatics Phase 4,Phase 3
13 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1
14 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1
15 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
17
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
18
Glycerol Approved, Investigational Phase 3 56-81-5 753
19
Petrolatum Approved, Investigational Phase 3 8009-03-8
20
Doxycycline Approved, Investigational, Vet_approved Phase 3,Phase 2 564-25-0 54671203
21
Ropivacaine Approved Phase 3 84057-95-4 175805 71273
22
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
23
Rifampin Approved Phase 2, Phase 3 13292-46-1 5381226 5458213
24
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
25 Anesthetics Phase 3
26 Anesthetics, Local Phase 3
27 Disinfectants Phase 3
28 Eusol Phase 3
29 Protective Agents Phase 3,Phase 2
30 Sodium hypochlorite Phase 3
31 Antimalarials Phase 3,Phase 2
32 Central Nervous System Depressants Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Pharmaceutical Solutions Phase 3,Phase 2
35 Antitubercular Agents Phase 2, Phase 3
36 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
37 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
38 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
39 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
40
Selenious acid Approved, Investigational Phase 2 7783-00-8
41
Selenium Approved, Investigational, Vet_approved Phase 2 7782-49-2
42
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
43
Methylene blue Approved, Investigational Phase 2 61-73-4
44
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
45
Octreotide Approved, Investigational Phase 2 83150-76-9 6400441 383414
46
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
47
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 2,Phase 1 90-89-1 3052
48
Propranolol Approved, Investigational Phase 2 525-66-6 4946
49
Digoxin Approved Phase 2 20830-75-5 2724385 30322
50 Tocopherol Approved, Investigational, Nutraceutical Phase 2

Interventional clinical trials:

(show top 50) (show all 327)

# Name Status NCT ID Phase Drugs
1 Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema Completed NCT01068431 Phase 4
2 Low Level Laser Treatment and Breast Cancer Related Lymphedema Completed NCT00852930 Phase 4
3 Comparison Between a Non-elastic Falcro Device and Current Method After Total Knee Arthroplasty Completed NCT02375945 Phase 4
4 A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction Completed NCT01561287 Phase 4
5 A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection Completed NCT02476357 Phase 4
6 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4 Penicillin VK
7 Post-Operative Drainage Following Lymph Node Dissection Completed NCT00324272 Phase 4 Fibrin Sealant (Tisseel) used in the Experimental Arm.
8 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
9 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4 400 μg/kg Ivermectin + 400 mg Albendazole
10 Lower-Limb Drainage Mapping in Pelvic Lymphadenectomy for Gynaecological Cancer Active, not recruiting NCT01946672 Phase 4
11 Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity Terminated NCT01255631 Phase 4
12 Flexitouch Compression System for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
13 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
14 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
15 Prevention of Pelvic Lymphocele by Floseal During Pelvic Lymphadenectomy for Gynecologic Cancer Unknown status NCT01974193 Phase 3 Floseal
16 Randomized Trial of Exercise on Lower Extremity Edema After Lymphadenectomy in Gynecologic Cancer Unknown status NCT01849224 Phase 3
17 Lymphedema Upper Limb of Breast Cancer Through Muscle Strengthening Associated With Complex Physical Therapy Completed NCT02574780 Phase 2, Phase 3
18 Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva Completed NCT00028951 Phase 3 fibrin sealant
19 Trial of Decongestive Lymphatic Therapy for Lymphedema in Women With Breast Cancer "DELTA STUDY" Completed NCT00201890 Phase 3
20 Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer? Completed NCT00175344 Phase 3
21 Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes Completed NCT00287196 Phase 3
22 Effects of Aerobic Exercise Versus Weight Training in Breast Cancer Survivors During Chemotherapy Completed NCT00115713 Phase 3
23 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
24 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3 Ivermectin;Albendazole
25 Pre-existing Factors, Early Detection and Early Treatment of Breast Cancer Related Lymphedema Recruiting NCT03210311 Phase 3
26 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
27 Conventional Versus Hypofractionated Radiotherapy in Node Positive Breast Cancer Recruiting NCT02690636 Phase 3
28 Breast Cancer Rehabilitation With Acupuncture and Physical Therapy Protocol Recruiting NCT02798263 Phase 2, Phase 3
29 Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma Recruiting NCT02166788 Phase 3
30 MIRs03: Paravertebral Block With Ropivacaine Before Breast Cancer Surgery Recruiting NCT02408393 Phase 3 Saline;Ropivacaine
31 Hypofractionated Radiation Therapy After Mastectomy in Preventing Recurrence in Patients With Stage IIa-IIIa Breast Cancer Recruiting NCT03414970 Phase 3
32 Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Active, not recruiting NCT00376597 Phase 3
33 WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Active, not recruiting NCT01659437 Phase 2, Phase 3 Clarithromycin Extended Release;Streptomycin intramuscular injection
34 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3 Doxycycline;Placebo
35 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
36 Effects of an e-Home Based Symptom Management and Mindfulness Training Programme on QoL in Breast Cancer Survivors Not yet recruiting NCT02931864 Phase 3
37 Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer Terminated NCT00577317 Phase 3
38 Treatment of Lymphedema: Application of the Kinesio Taping Unknown status NCT00155220 Phase 2
39 Hyperbaric Oxygen Therapy Compared With Standard Therapy in Treating Chronic Arm Lymphedema in Patients Who Have Undergone Radiation Therapy for Cancer Unknown status NCT00077090 Phase 2 hyperbaric oxygen
40 Therapeutical Assessment of Compression Armsleeves for Lymphatic Indications Unknown status NCT01318785 Phase 2
41 Breast Lymph Node Mapping Unknown status NCT01038908 Phase 2
42 The Effect of Combined Decongestive Therapy and Pneumatic Compression Pump on Body Image in Patients With Lymphedema Completed NCT02650297 Phase 1, Phase 2
43 Pycnogenol for the Treatment of Lymphedema Completed NCT00214032 Phase 2 Pycnogenol;Placebo
44 Acupuncture for the Treatment of Chronic Lymphedema Completed NCT01003951 Phase 2
45 A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer Completed NCT00827372 Phase 2 Pazopanib
46 Use of Stem Cells in Lymphedema Post Mastectomy Completed NCT01112189 Phase 1, Phase 2
47 Horse Chestnut Seed Extract for Lymphedema Completed NCT00213928 Phase 2 Horse Chestnut Seed Extract
48 The Use of Selenium to Treat Secondary Lymphedema - Breast Cancer Completed NCT00188604 Phase 2 sodium selenite
49 Pycnogenol for the Treatment of Lymphedema of the Arm in Breast Cancer Survivors Completed NCT00064857 Phase 2 Pycnogenol
50 Vitamin E and Pentoxifylline in Treating Women With Lymphedema After Radiation Therapy for Breast Cancer Completed NCT00022204 Phase 2 pentoxifylline

Search NIH Clinical Center for Lymphedema

Cochrane evidence based reviews: lymphedema

Genetic Tests for Lymphedema

Genetic tests related to Lymphedema:

# Genetic test Affiliating Genes
1 Lymphedema 28

Anatomical Context for Lymphedema

MalaCards organs/tissues related to Lymphedema:

38
Lymph Node, Skin, Breast, Endothelial, Testes, Liver, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Lymphedema:
# Tissue Anatomical CompartmentCell Relevance
1 Heart Cardinal Veins Venous Endothelial Cells Potential therapeutic candidate, affected by disease

Publications for Lymphedema

Articles related to Lymphedema:

(show top 50) (show all 929)
# Title Authors Year
1
Further delineation of the SOX18-related Hypotrichosis, Lymphedema, Telangiectasia syndrome (HTLS). ( 29307792 )
2018
2
Primary lymphedema and other lymphatic anomalies are associated with 22q11.2 deletion syndrome. ( 29447908 )
2018
3
Novel FOXC2 Mutation and Distichiasis in a Patient With Lymphedema-Distichiasis Syndrome. ( 29406328 )
2018
4
Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema. ( 29324858 )
2018
5
Clinical effectiveness of decongestive treatments on excess arm volume and patient-centered outcomes in women with early breast cancer-related arm lymphedema: a systematic review. ( 29419623 )
2018
6
Quality of Life Questionnaires in Breast Cancer-Related Lymphedema Patients: Review of the Literature. ( 29437542 )
2018
7
The potential role of angiogenesis in the development of shoulder pain, shoulder dysfunction, and lymphedema after breast cancer treatment. ( 29391829 )
2018
8
Reply to Letter to the Editor "Vectra 3D Imaging for Quantitative Volumetric Analysis of the Upper Limb: A Feasibility Study for Tracking Outcomes of Lymphedema Treatment". ( 29381551 )
2018
9
Vectra 3D Imaging for Suprapubic Lymphedema and Volume Change of the Lower Abdomen Associated with Lower Extremity Lymphedema. ( 29381554 )
2018
10
Association between extremity kaposiform hemangioendothelioma and lymphedema. ( 29266383 )
2018
11
Growing Insights into Breast Cancer-Related Lymphedema. ( 29432070 )
2018
12
Function, Shoulder Motion, Pain, and Lymphedema in Breast Cancer With and Without Axillary Web Syndrome: An 18-Month Follow-Up. ( 29361075 )
2018
13
A lymphedema surveillance program for breast cancer patients reveals the promise of surgical prevention. ( 29397949 )
2018
14
Head and neck lymphedema management: Evaluation of a therapy program. ( 29385298 )
2018
15
The incidence and risk factors of related lymphedema for breast cancer survivors post-operation: a 2-year follow-up prospective cohort study. ( 29397555 )
2018
16
Genetic tests in lymphatic vascular malformations and lymphedema. ( 29440349 )
2018
17
Lymphedema-Distichiasis Syndrome in a Male Patient Followed for 16 Years. ( 29342028 )
2018
18
Lymphedema in ovarian cancer survivors: Assessing diagnostic methods and the effects of physical activity. ( 29437202 )
2018
19
A quantitative evaluation with an innovative wireless bio-impedance device to check improvement of limb lymphedema after receiving two-site vascularized lymph node transfer simultaneously in a patient. ( 29446479 )
2018
20
Correction to: "Effects of Aqua-Lymphatic Therapy on Lower Extremity Lymphedema: A Randomized Controlled Study" by G Ergin, D Karadibak, HO Sener, and B Gurpinar Lymphatic Research and Biology 2017; 15(3): 284-291 DOI: 10.1089/lrb.2017.0017. ( 29432065 )
2018
21
Comparison of long-term clinical outcomes among different vascularized lymph node transfers: 6-year experience of a single center's approach to the treatment of lymphedema. ( 29357118 )
2018
22
The Effect of Lymphaticovenous Anastomosis in Breast Cancer-Related Lymphedema: A Review of the Literature. ( 29356596 )
2018
23
Correlation Between Changes in Extremity Volume and Bioelectrical Impedance in Arm and Leg Lymphedema. ( 29356595 )
2018
24
Hand Edema in Patients at Risk of Breast Cancer-Related Lymphedema (BCRL): Health Professionals Should Take Notice. ( 29361079 )
2018
25
Supermicrosurgical lymphaticovenous anastomosis for a patient with breast lymphedema secondary to breast cancer treatment. ( 28052379 )
2017
26
Near-Infrared Fluorescence Lymphatic Imaging of a Toddler With Congenital Lymphedema. ( 28356336 )
2017
27
Effectiveness of acupuncture for breast cancer related lymphedema: protocol for a single-blind, sham-controlled, randomized, multicenter trial. ( 28934950 )
2017
28
The application of negative pressure wound therapy combined with compression bandaging for the decubitus ulcer of an advanced primary lower limb lymphedema. ( 28244063 )
2017
29
Surgical treatment of secondary lymphedema of the upper limb by stepped microsurgical lymphaticovenous anastomoses. ( 28083821 )
2017
30
Clinical Treatment of Penile Fibrosis After Penoscrotal Lymphedema. ( 28083477 )
2017
31
Effects of Aqua-Lymphatic Therapy on Lower Extremity Lymphedema: A Randomized Controlled Study. ( 28880750 )
2017
32
Streptococcal toxic-shock syndrome due to Streptococcus dysgalactiae subspecies equisimilis in breast cancer-related lymphedema: a case report. ( 28705211 )
2017
33
T-regulatory cells mediate local immunosuppression in lymphedema. ( 28942366 )
2017
34
Translation and Validation of the Turkish Version of Lymphedema Quality of Life Tool (LYMQOL) in Patients with Breast Cancer Related Lymphedema. ( 28894851 )
2017
35
Strategic recruitment of an ethnically diverse cohort of overweight survivors of breast cancer with lymphedema. ( 28881471 )
2017
36
Volume and Tissue Composition Changes Measured with Dual-Energy X-Ray Absorptiometry in Melanoma-Related Limb Lymphedema. ( 28885862 )
2017
37
Breast angiosarcoma without radiation history, putatively associated with subclinical lymphedema: A case report and review of the Japanese literature. ( 28543441 )
2017
38
Renal anomalies and lymphedema distichiasis syndrome. A rare association? ( 28544699 )
2017
39
Effects of a complex rehabilitation program on edema status, physical function, and quality of life in lower-limb lymphedema after gynecological cancer surgery. ( 28941657 )
2017
40
Primary cutaneous anaplastic large cell lymphoma with intralymphatic involvement associated with chronic lymphedema. ( 28337783 )
2017
41
Interosseous Membrane Release for Long-Standing Upper Limb Lymphedema: A Procedure Often Neglected. ( 28894671 )
2017
42
Kaposi sarcoma: An unconventional cause of lower extremity lymphedema. ( 28875759 )
2017
43
Therapeutic effects of hyaluronidase on acquired lymphedema using a newly developed mouse limb model. ( 28092183 )
2017
44
Reply to: Precautionary Behaviors and Breast Cancer-Related Lymphedema. ( 28880728 )
2017
45
Platysma-sparing vascularized submental lymph node flap transfer for extremity lymphedema. ( 28058777 )
2017
46
Hereditary Lymphedema of the Leg - A Case Report. ( 28785330 )
2017
47
Pediatric genital lymphedema with recurrent hydrocele and late-onset secondary skin changes. ( 27978613 )
2017
48
Vulvar lymphedema and refractory VIN-III heralding GATA2 deficiency syndrome. ( 28947108 )
2017
49
Surgical Treatment of Primary Lymphedema. ( 28880720 )
2017
50
Diagnostic Methods, Risk Factors, Prevention, and Management of Breast Cancer-Related Lymphedema: Past, Present, and Future Directions. ( 28894513 )
2017

Variations for Lymphedema

Expression for Lymphedema

Search GEO for disease gene expression data for Lymphedema.

Pathways for Lymphedema

Pathways related to Lymphedema according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 FLT4 IKBKG KDR NRP2 PTPN14 VEGFC
2
Show member pathways
12.71 FLT4 IKBKG KDR NRP2 VEGFC
3
Show member pathways
12.45 FLT4 IKBKG KDR VEGFC
4
Show member pathways
12.41 FLT4 IKBKG KDR VEGFC
5
Show member pathways
12.25 FLT4 IKBKG KDR NRP2 VEGFC
6
Show member pathways
11.93 FLT4 KDR NRP2 VEGFC
7 11.82 FLT4 KDR VEGFC
8 11.7 GATA2 KDR PROX1
9
Show member pathways
11.42 FLT4 KDR NRP2 VEGFC
10 11.04 FLT4 KDR NRP2 PROX1 PTPN14 VEGFC
11 10.82 FLT4 VEGFC
12
Show member pathways
10.34 FLT4 KDR VEGFC

GO Terms for Lymphedema

Biological processes related to Lymphedema according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.8 FLT4 KDR NRP2 SOX18 VEGFC
2 positive regulation of angiogenesis GO:0045766 9.76 CCBE1 GATA2 KDR VEGFC
3 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.72 FLT4 FOXC2 KDR NRP2 VEGFC
4 kidney development GO:0001822 9.71 FAT4 FOXC2 PROX1
5 positive regulation of endothelial cell proliferation GO:0001938 9.65 FLT4 KDR NRP2 PROX1 VEGFC
6 positive regulation of endothelial cell migration GO:0010595 9.63 CCBE1 FLT4 FOXC2 KDR NRP2 PROX1
7 positive regulation of macroautophagy GO:0016239 9.61 IKBKG KDR
8 positive regulation of vascular endothelial growth factor production GO:0010575 9.61 CCBE1 FLT4
9 sprouting angiogenesis GO:0002040 9.6 CCBE1 FLT4
10 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.59 FLT4 KDR
11 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.58 FOXC2 PROX1
12 vasculature development GO:0001944 9.58 FLT4 SOX18
13 embryonic heart tube development GO:0035050 9.57 FOXC2 SOX18
14 cell fate determination GO:0001709 9.55 GATA2 PROX1
15 vascular endothelial growth factor signaling pathway GO:0038084 9.54 FLT4 KDR NRP2
16 respiratory system process GO:0003016 9.52 CCBE1 FLT4
17 venous blood vessel morphogenesis GO:0048845 9.51 CCBE1 PROX1
18 lymphatic endothelial cell differentiation GO:0060836 9.49 PROX1 SOX18
19 endocardium formation GO:0060214 9.48 PROX1 SOX18
20 positive regulation of lymphangiogenesis GO:1901492 9.43 CCBE1 VEGFC
21 lymph vessel development GO:0001945 9.35 CCBE1 FLT4 FOXC2 PROX1 SOX18
22 lymphangiogenesis GO:0001946 9.1 CCBE1 FLT4 FOXC2 PROX1 PTPN14 SOX18
23 multicellular organism development GO:0007275 10.03 CCBE1 FOXC2 KDR NRP2 PROX1 VEGFC

Molecular functions related to Lymphedema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor binding GO:0019838 9.13 FLT4 KDR NRP2
2 vascular endothelial growth factor-activated receptor activity GO:0005021 8.8 FLT4 KDR NRP2

Sources for Lymphedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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