MCID: LYM025
MIFTS: 49

Lymphedema malady

Cardiovascular category

Summaries for Lymphedema

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Lymphedema is the name of a type of swelling. it happens when lymph builds up in your body's soft tissues. lymph is a fluid that contains white blood cells that defend against germs. it can build up when the lymph system is damaged or blocked. it usually happens in the arms or legs. causes of lymphedema include infection cancer scar tissue from radiation therapy or surgical removal of lymph nodes inherited conditions in which lymph nodes or vessels are absent or abnormal treatment can help control symptoms. it includes exercise, compression devices, skin care, and massage. nih: national cancer institute

MalaCards: Lymphedema, also known as lymphedema, acquired, is related to lymphedema-distichiasis syndrome and lymphedema, congenital. An important gene associated with Lymphedema is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are p70S6K Signaling and Heart Development. The compound vegf have been mentioned in the context of this disorder. Related mouse phenotypes are pigmentation and normal.

CDC:3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

Wikipedia:64 Lymphedema (lymphoedema in British English), also known as lymphatic obstruction, is a condition of... more...

Aliases & Classifications for Lymphedema

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

lymphedema 8 10 45 34 61
lymphedema, acquired 8
lymphatic edema 8
lymphoedema nos 8
lymphoedema 8


External Ids:

Disease Ontology8 DOID:4977
NCIt40 C3207
MeSH35 D008209
ICD1025 I89.0

Related Diseases for Lymphedema

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Lymphedema family:

lymphedema, congenital lymphedema, primary, with myelodysplasia
congenital primary lymphedema

Diseases related to Lymphedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1lymphedema-distichiasis syndrome30.9FOXC2
2lymphedema, congenital30.9FIGF, VEGFC, FOXC2, PDPN, FLT4
3lymphangiosarcoma30.9PROX1
4yellow nail syndrome30.7SOX18
5angiosarcoma30.5PDPN, FLT4, VEGFC
6mongolian spot30.2FOXC2, SOX18
7hydrops fetalis30.2FLT4
8hemangioendothelioma29.9FLT4
9squamous cell carcinoma29.9OXA1L, PDPN, FLT4, VEGFC, FIGF
10klippel-trenaunay syndrome29.7FOXC2, SOX18, FLT4
11inflammatory breast carcinoma29.7VEGFC, FIGF, PROX1
12kaposi's sarcoma29.7VEGFC, FLT4, PDPN
13hereditary lymphedema10.7
14hereditary lymphedema type ii10.5
15meige lymphedema10.4
16hennekam syndrome10.4
17n syndrome10.4
18hypotrichosis-lymphedema-telangiectasia syndrome10.4
19aagenaes syndrome10.3
20lipedema10.3
21erysipelas10.3
22microcephaly10.3
23congenital primary lymphedema10.3
24breast reconstruction10.2
25microcephaly with or without chorioretinopathy, lymphedema, or mental retardation10.2
26micro syndrome10.2
27chylous ascites10.2
28lymphedema and cerebral arteriovenous anomaly10.2
29lymphangitis10.2
30lymphedema, microcephaly and chorioretinopathy syndrome10.2
31hereditary lymphedema ic10.2
32arthritis10.1
33tuberous sclerosis10.1
34filarial elephantiasis10.1
35turner syndrome10.1
36dahlberg borer newcomer syndrome10.1
37mental retardation10.1
38lymphedema - atrial septal defects - facial changes10.1
39lymphangioleiomyomatosis10.1
40cellulitis10.1
41noonan syndrome10.1
42protein-losing enteropathy10.1
43down syndrome10.1
44podoconiosis10.1
45vulva cancer10.1
46char syndrome10.1
47arachnoid cysts10.1
48lymphedema, primary, with myelodysplasia10.1
49emberger syndrome10.1
50ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency10.1

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to lymphedema

Clinical Features for Lymphedema

Drugs & Therapeutics for Lymphedema

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphedema

Drug clinical trials:

Search ClinicalTrials for Lymphedema

Search NIH Clinical Center for Lymphedema

Search CenterWatch for Lymphedema

Genetic Tests for Lymphedema

Anatomical Context for Lymphedema

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Lymphedema:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Potential therapeutic candidate, affected by disease

Animal Models for Lymphedema or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lymphedema

Sources:
51PubMed
See all sources

Articles related to Lymphedema:

(show top 50)    (show all 704)
idTitleAuthorsYear
1
Acquired idiopathic penile lymphedema: Successful prevention of acute phase progression with low-dose corticosteroids. (24387075)
2014
2
Agreement between telerehabilitation involving caregivers and face-to-face clinical assessment of lymphedema in breast cancer survivors. (24043290)
2014
3
Effects of qigong exercise on upper limb lymphedema and blood flow in survivors of breast cancer: a pilot study. (23749481)
2014
4
Congenital Segmental Lymphedema in Tuberous Sclerosis Complex With Associated Subependymal Giant Cell Astrocytomas Treated with Mammalian Target of Rapamycin Inhibitors. (24056156)
2013
5
Comparison of lymphedema in patients with axillary lymph node dissections to those with sentinel lymph node biopsy followed by immediate and delayed ALND. (22157215)
2013
6
Indocyanine green velocity: lymph transportation capacity deterioration with progression of lymphedema. (24126343)
2013
7
Primary congenital lymphedema complicated by hydrops fetalis: a case report and review of the literature. (23533860)
2013
8
Prevalence of lymphedema in women undergoing treatment for breast cancer in a referral center in southeastern Brazil. (23406386)
2013
9
Whole-body bioelectrical impedance analysis in assessing upper-limb lymphedema after breast cancer therapy. (24123030)
2013
10
Peripheral venous angle plasty: a new lymphovenous anastomosis technique for lower extremity lymphedema. (22743945)
2012
11
Liposuction normalizes - in contrast to other therapies - lymphedema-induced adipose tissue hypertrophy. (23283813)
2012
12
Localized xanthomas associated with primary lymphedema. (22256994)
2012
13
Current views on diagnostic approach and treatment of lymphedema. (22269614)
2012
14
GATA-2 anomaly and clinical phenotype of a sporadic case of lymphedema, dendritic cell, monocyte, B- and NK-cell (DCML) deficiency, and myelodysplasia. (22430350)
2012
15
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy. (22284827)
2012
16
Breast cancer-related lymphedema: comparing direct costs of a prospective surveillance model and a traditional model of care. (21921254)
2012
17
Lymphedema: still a problem without an answer. (22545307)
2012
18
Primary lymphedema: definition of onset based on developmental age. (22186578)
2012
19
Systematic review: conservative treatments for secondary lymphedema. (22216837)
2012
20
Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery. (23342930)
2012
21
9-cis retinoic acid promotes lymphangiogenesis and enhances lymphatic vessel regeneration: therapeutic implications of 9-cis retinoic acid for secondary lymphedema. (22275501)
2012
22
Overview of treatments for male genital lymphedema: critical literature review and anatomical considerations. (22456418)
2012
23
Incidence and risk factors of lower-extremity lymphedema after radical surgery with or without adjuvant radiotherapy in patients with FIGO stage I to stage IIA cervical cancer. (22398707)
2012
24
Nomograms for predicting the risk of arm lymphedema after axillary dissection in breast cancer. (22395997)
2012
25
Podoconiosis: the forgotten tropical lymphedema. (23008936)
2012
26
Management of lymphedema. (22950562)
2012
27
Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery. (23700765)
2012
28
Idiopathic portal hypertension and lower limb lymphedema. (23057151)
2012
29
Lymphedema in patients with head and neck cancer. (21186146)
2011
30
Massive localized lymphedema: A case series and literature review. (22942667)
2011
31
Indocyanine green-enhanced lymphography for upper extremity lymphedema: a novel severity staging system using dermal backflow patterns. (21681123)
2011
32
Prevalence and prognostic significance of secondary lymphedema following breast cancer. (22066743)
2011
33
Lymphedema and breast cancer: a review of the literature. (21331463)
2011
34
Morbidity of sentinel node biopsy: relationship between number of excised lymph nodes and patient perceptions of lymphedema. (21465310)
2011
35
A novel missense mutation and two microrearrangements in the FOXC2 gene of three families with lymphedema-distichiasis syndrome. (20552815)
2010
36
Large nodular plaque on leg in the setting of chronic lymphedema--quiz case. Angiosarcoma in the setting of familial lymphedema. (20231513)
2010
37
Cutaneous tumors, massive lymphadenopathy, and secondary lymphedema in a 16-year-old boy--quiz case. African/endemic Kaposi sarcoma (KS): lymphadenopathic form. (18794470)
2008
38
Spinal extradural arachnoid cysts associated with distichiasis and lymphedema. (17366583)
2007
39
Persistent periorbital and facial lymphedema associated with Group A beta-hemolytic streptococcal infection (erysipelas). (17413641)
2007
40
The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis. (16081467)
2005
41
Successful octreotide treatment of chylous pleural effusion and lymphedema in the yellow nail syndrome. (15289232)
2004
42
FOXC2 truncating mutation in distichiasis, lymphedema, and cleft palate. (12485195)
2002
43
Insights into the molecular pathogenesis and targeted treatment of lymphedema. (12543720)
2002
44
Mapping of the locus for cholestasis-lymphedema syndrome (Aagenaes syndrome) to a 6.6-cM interval on chromosome 15q. (10968776)
2000
45
Lymphedema-Distichiasis Syndrome (20301630)
1993
46
Autosomal recessive intestinal lymphangiectasia and lymphedema, with facial anomalies and mental retardation. (2624276)
1989
47
Congenital hereditary lymphedema in the pig. (642582)
1978
48
Scintilymphangiography with 99 mTc-antimony sulfide colloid in hereditary lymphedema (Nonne-Milroy diseases). (709985)
1978
49
Hereditary lymphedema and obstructive jaundice. (5544157)
1971
50
Elephantiasis nostras nasalis; circumscribed lymphedema of the nose. (14797434)
1950

Genetic Variations for Lymphedema

Expression for genes affiliated with Lymphedema

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphedema

Search GEO for disease gene expression data for Lymphedema.

Pathways for genes affiliated with Lymphedema

Sources:
52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 50PharmGKB, 56SinoBiological, 30KEGG
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Compounds for genes affiliated with Lymphedema

Sources:
45Novoseek
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Compounds related to Lymphedema according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vegf4510.2FIGF, VEGFC, PROX1, FLT4, PDPN

GO Terms for genes affiliated with Lymphedema

Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056349.9PTPN14, SOX18, FOXC2, FOXC1, FOXL1, GATA2

Biological processes related to Lymphedema according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1embryonic heart tube developmentGO:03505010.7SOX18, FOXC1, FOXC2
2positive regulation of mast cell chemotaxisGO:06075410.7FIGF, VEGFC
3endocardium formationGO:06021410.7SOX18, PROX1
4venous blood vessel morphogenesisGO:04884510.7PROX1, CCBE1
5lymph vessel developmentGO:00194510.7FOXC1, FLT4
6positive regulation of endothelial cell migrationGO:01059510.7FLT4, PROX1, FOXC2
7lymphatic endothelial cell differentiationGO:06083610.7PROX1, SOX18
8camera-type eye developmentGO:04301010.7FOXC1, FOXC2, FOXL1
9ventricular cardiac muscle tissue morphogenesisGO:05501010.7PROX1, FOXC1, FOXC2
10regulation of organ growthGO:04662010.6FOXC1, FOXC2
11cardiac muscle cell proliferationGO:06003810.6FOXC1, FOXC2
12regulation of blood vessel sizeGO:05088010.6FOXC2, FOXC1
13vascular endothelial growth factor receptor signaling pathwayGO:04801010.6FOXC2, FOXC1, FLT4, VEGFC, FIGF
14induction of positive chemotaxisGO:05093010.5VEGFC, FIGF
15neural crest cell developmentGO:01403210.5FOXC2, FOXC1
16embryo developmentGO:00979010.5PDPN, FOXL1, FOXC1
17lymphangiogenesisGO:00194610.5SOX18, FOXC2, FLT4, PROX1, PTPN14, CCBE1
18negative regulation of transcription from RNA polymerase II promoterGO:00012210.5FOXC1, GATA2, PROX1, SOX18, FOXC2
19sprouting angiogenesisGO:00204010.5CCBE1, FLT4
20artery morphogenesisGO:04884410.4FOXC2, FOXC1
21positive regulation of transcription from RNA polymerase II promoterGO:04594410.4FOXC2, IKBKG, GATA2, FOXC1, SOX18
22heart developmentGO:00750710.3FOXL1, FOXC1, FOXC2
23vasculature developmentGO:00194410.3FLT4, SOX18
24tissue developmentGO:00988810.1FOXL1, FOXC1

Molecular functions related to Lymphedema according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor receptor 3 bindingGO:04318510.5FIGF, VEGFC
2DNA binding, bendingGO:00830110.4FOXC2, FOXC1, FOXL1
3transcription regulatory region DNA bindingGO:04421210.4SOX18, PROX1, FOXC1, FOXC2
4chemoattractant activityGO:04205610.4FIGF, VEGFC
5RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:00107710.3GATA2, FOXC2, SOX18
6sequence-specific DNA binding transcription factor activityGO:00370010.1FOXC2, FOXC1, FOXL1, SHOX, GATA2, PROX1
7RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityGO:00370510.0FOXC1, FOXC2, PROX1

Products for genes affiliated with Lymphedema

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Sources for Lymphedema

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet