MCID: LYM025
MIFTS: 61

Lymphedema malady

Categories: Immune diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Lymphedema

Aliases & Descriptions for Lymphedema:

Name: Lymphedema 38 12 29 52 41 3 42 14 69
Lymphatic Edema 12
Lymphoedema Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4977
MeSH 42 D008209
NCIt 47 C3207
UMLS 69 C0024236

Summaries for Lymphedema

MedlinePlus : 41 lymphedema is the name of a type of swelling. it happens when lymph builds up in your body's soft tissues. lymph is a fluid that contains white blood cells that defend against germs. it can build up when the lymph system is damaged or blocked. it usually happens in the arms or legs. causes of lymphedema include infection cancer scar tissue from radiation therapy or surgical removal of lymph nodes inherited conditions in which lymph nodes or vessels are absent or abnormal treatment can help control symptoms. it includes exercise, compression devices, skin care, and massage. nih: national cancer institute

MalaCards based summary : Lymphedema, also known as lymphatic edema, is related to oculodentodigital dysplasia and lymphedema-distichiasis syndrome, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Lymphedema is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways/superpathways are TRAF Pathway and VEGF Pathway (Qiagen). The drugs Penicillin V and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include Heart, breast and lymph node, and related phenotypes are Decreased viability in esophageal squamous lineage and cardiovascular system

CDC : 3 Lymphatic filariasis, considered globally as a neglected tropical disease , is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

Wikipedia : 71 Lymphedema, also known as lymphoedema and lymphatic edema, is a condition of localized fluid retention... more...

Related Diseases for Lymphedema

Diseases in the Lymphedema family:

Lymphedema, Hereditary, Ic Lymphedema, Hereditary, Id
Lymphedema, Hereditary, Ia Lymphedema, Hereditary, Ib
Hereditary Lymphedema Congenital Lymphedema
Hereditary Lymphedema Type Ii

Diseases related to Lymphedema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
id Related Disease Score Top Affiliating Genes
1 oculodentodigital dysplasia 30.7 FLT4 FOXC2 GJC2 PROX1 SOX18 VEGFC
2 lymphedema-distichiasis syndrome 12.4
3 hereditary lymphedema 12.3
4 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 12.3
5 hereditary lymphedema type ii 12.3
6 hypotrichosis-lymphedema-telangiectasia syndrome 12.3
7 cholestasis-lymphedema syndrome 12.2
8 lymphedema, hereditary, ia 12.2
9 choanal atresia and lymphedema 12.1
10 lymphedema, hereditary, ic 12.1
11 hennekam lymphangiectasia-lymphedema syndrome 2 12.1
12 hennekam lymphangiectasia-lymphedema syndrome 1 12.1
13 ectodermal, dysplasia, anhidrotic, lymphedema and immunodeficiency 12.1
14 lymphedema, hereditary, id 12.0
15 deafness-lymphedema-leukemia syndrome 12.0
16 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 12.0
17 lymphedema, hereditary, ib 11.9
18 hennekam syndrome 11.9
19 congenital lymphedema 11.9
20 yellow nail syndrome 11.9
21 lymphedema and cerebral arteriovenous anomaly 11.8
22 lymphedema, cardiac septal defects, and characteristic facies 11.7
23 emberger syndrome 11.7
24 lymphedema-hypoparathyroidism syndrome 11.7
25 lymphangiosarcoma 11.5
26 microcephaly and chorioretinopathy, autosomal recessive, 1 11.3
27 podoconiosis 11.0
28 turner syndrome 11.0
29 bier spots 11.0
30 irons bhan syndrome 10.8
31 dahlberg borer newcomer syndrome 10.8
32 filarial elephantiasis 10.8
33 immunodeficiency 33 10.7
34 takenouchi-kosaki syndrome 10.7
35 angiosarcoma of the scalp 10.7
36 immunodeficiency 21 10.7
37 verruciform xanthoma of skin 10.7
38 lymphatic system disease 10.7
39 breast cancer 10.5
40 nail disorder, nonsyndromic congenital, 10, 10.2 FLT4 FOXC2 SOX18
41 weyers ulnar ray/oligodactyly syndrome 10.2 FLT4 FOXC2 SOX18
42 acromesomelic dysplasia, maroteaux type 10.2 FLT4 FOXC2 SOX18
43 distichiasis 10.2
44 lysteria monocytoigeneses meningitis 10.2 FLT4 PROX1
45 obstructive sleep apnea 10.2 FOXC2 GJC2 SOX18
46 hypomelanosis of ito 10.2 FLT4 PROX1
47 bartholin's gland transitional cell carcinoma 10.2 FOXC2 GJC2 SOX18
48 pilomyxoid astrocytoma 10.2 FLT4 PROX1
49 gapo syndrome 10.2 FLT4 KDR
50 orofaciodigital syndrome 13 10.2 FLT4 PDPN

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to Lymphedema

Symptoms & Phenotypes for Lymphedema

UMLS symptoms related to Lymphedema:


angina pectoris, chest pain, edema, localized edema, joint swelling

GenomeRNAi Phenotypes related to Lymphedema according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.28 CCBE1 FLT4 FOXC2 FOXL1 GATA2 KIF11

MGI Mouse Phenotypes related to Lymphedema:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.16 FLT4 FOXC2 GATA2 KDR NRP2 PDPN
2 growth/size/body region MP:0005378 10.15 FOXC2 FOXL1 GATA2 KDR KIF11 NRP2
3 homeostasis/metabolism MP:0005376 10.1 CCBE1 FLT4 FOXC2 GATA2 KDR NRP2
4 immune system MP:0005387 10.03 CCBE1 FLT4 FOXC2 GJC2 KDR NRP2
5 embryo MP:0005380 9.95 FLT4 FOXC2 GATA2 KDR KIF11 NRP2
6 digestive/alimentary MP:0005381 9.91 FOXL1 PDPN PROX1 SOX18 FLT4 FOXC2
7 mortality/aging MP:0010768 9.83 CCBE1 FLT4 FOXC2 FOXL1 GATA2 GJC2
8 liver/biliary system MP:0005370 9.63 CCBE1 FLT4 FOXC2 GATA2 KDR PROX1
9 normal MP:0002873 9.28 CCBE1 FLT4 FOXC2 GATA2 GJC2 KDR

Drugs & Therapeutics for Lymphedema

Drugs for Lymphedema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Penicillin V Approved, Vet_approved Phase 4 87-08-1 6869
2
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 54965-21-8 2082
3
Ivermectin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 70288-86-7 6474909 46936176
4
Benzocaine Approved Phase 4 1994-09-7, 94-09-7 2337
5
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
6 tannic acid Approved, Nutraceutical Phase 4
7 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
8 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3
9 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
10 penicillins Phase 4
11 Coagulants Phase 4,Phase 3
12 Fibrin Tissue Adhesive Phase 4,Phase 3
13 Hemostatics Phase 4,Phase 3
14 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1
15 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1
16 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
17 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Radiopharmaceuticals Phase 4,Phase 2
19
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
20
Glycerol Approved, Experimental Phase 3 56-81-5 753
21
Petrolatum Approved Phase 3 8009-03-8
22
Ropivacaine Approved Phase 3 84057-95-4 71273 175805
23
Doxycycline Approved, Investigational, Vet_approved Phase 3,Phase 2 564-25-0 54671203
24
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
25
Rifampin Approved Phase 2, Phase 3 13292-46-1 5458213 5381226
26
Streptomycin Approved, Vet_approved Phase 2, Phase 3 57-92-1 19649
27 Disinfectants Phase 3
28 Eusol Phase 3
29 Protective Agents Phase 3,Phase 2
30 Sodium hypochlorite Phase 3
31 Anesthetics Phase 3
32 Anesthetics, Local Phase 3
33 Central Nervous System Depressants Phase 3
34 Peripheral Nervous System Agents Phase 3
35 Antimalarials Phase 3,Phase 2
36 Pharmaceutical Solutions Phase 3,Phase 2
37 Antitubercular Agents Phase 2, Phase 3
38 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3
39 Cytochrome P-450 CYP3A Inhibitors Phase 2, Phase 3
40 Cytochrome P-450 Enzyme Inhibitors Phase 2, Phase 3
41 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3
42
Selenium Approved, Vet_approved Phase 2 7782-49-2
43
Pentoxifylline Approved, Investigational Phase 2 6493-05-6 4740
44
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
45
Octreotide Approved, Investigational Phase 2 83150-76-9 383414 6400441
46
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
47
Diethylcarbamazine Approved, Vet_approved Phase 2,Phase 1 90-89-1 3052
48
Technetium tc 99m sulfur colloid Approved Phase 2
49
Digoxin Approved Phase 2 20830-75-5 30322 2724385
50
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985

Interventional clinical trials:

(show top 50) (show all 297)
id Name Status NCT ID Phase
1 Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema Completed NCT01068431 Phase 4
2 Low Level Laser Treatment and Breast Cancer Related Lymphedema Completed NCT00852930 Phase 4
3 Home-based Compression Therapy for Arm and Truncal Lymphedema in Breast Cancer Completed NCT00880022 Phase 4
4 Comparison Between a Non-elastic Falcro Device and Current Method After Total Knee Arthroplasty Completed NCT02375945 Phase 4
5 A Comparison of Dermal Autograft to AlloDerm in Breast Reconstruction Completed NCT01561287 Phase 4
6 A Study for Lymphocele and Lymphorrhea Control Following Inguinal and Axillary Radical Lymph Node Dissection Completed NCT02476357 Phase 4
7 RCT to Investigate if Prophylactic Antibiotics Prevent Further Episodes of Cellulitis (Erysipelas) of the Leg Completed NCT00552799 Phase 4
8 Post-Operative Drainage Following Lymph Node Dissection Completed NCT00324272 Phase 4
9 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4
10 A Clinical Trial About the Contribution of Manual Lymph Drainage in Complex Physical Therapy for Patients With Lymphoedema Secondary to Mastectomy Recruiting NCT01152099 Phase 4
11 Lymphedema Following Hand/Wrist Surgery in Women Post Axillary Node Dissection Recruiting NCT00984269 Phase 4
12 Two Pneumatic Compression Devices in the Treatment of Lower Extremity Lymphedema Recruiting NCT01239160 Phase 4
13 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4
14 Lower-Limb Drainage Mapping in Pelvic Lymphadenectomy for Gynaecological Cancer Active, not recruiting NCT01946672 Phase 4
15 Pulsed Electromagnetic Fields (PEMF) and Post-Axillary Surgery Morbidity Terminated NCT01255631 Phase 4
16 Flexitouch Compression System for Venous Stasis Ulcer Terminated NCT00534937 Phase 4
17 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4
18 Treatment Trial for Post-Thrombotic Syndrome Unknown status NCT00633971 Phase 3
19 Prevention of Pelvic Lymphocele by Floseal During Pelvic Lymphadenectomy for Gynecologic Cancer Unknown status NCT01974193 Phase 3
20 Randomized Trial of Exercise on Lower Extremity Edema After Lymphadenectomy in Gynecologic Cancer Unknown status NCT01849224 Phase 3
21 Lymphedema Upper Limb of Breast Cancer Through Muscle Strengthening Associated With Complex Physical Therapy Completed NCT02574780 Phase 2, Phase 3
22 Fibrin Sealant in Decreasing Lymphedema Following Surgery to Remove Lymph Nodes in Patients With Cancer of the Vulva Completed NCT00028951 Phase 3
23 Trial of Decongestive Lymphatic Therapy for Lymphedema in Women With Breast Cancer "DELTA STUDY" Completed NCT00201890 Phase 3
24 Does Scar Massage Improve Postoperative Pain and Function in Women With Breast Cancer? Completed NCT00175344 Phase 3
25 Immediate Radiotherapy or Observation After Surgery for Melanoma Involving Lymph Nodes Completed NCT00287196 Phase 3
26 Effects of Aerobic Exercise Versus Weight Training in Breast Cancer Survivors During Chemotherapy Completed NCT00115713 Phase 3
27 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
28 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3
29 Preventive Intervention Against Lymphedema After Breast Cancer Surgery Recruiting NCT02518477 Phase 2, Phase 3
30 Conventional Versus Hypofractionated Radiotherapy in Node Positive Breast Cancer Recruiting NCT02690636 Phase 3
31 Breast Cancer Rehabilitation With Acupuncture and Physical Therapy Protocol Recruiting NCT02798263 Phase 2, Phase 3
32 Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma Recruiting NCT02166788 Phase 3
33 Sentinel Lymph Node Biopsy in Patients With Early Stages Cervical Cancer Recruiting NCT02494063 Phase 3
34 MIRs03: Paravertebral Block With Ropivacaine Before Breast Cancer Surgery Recruiting NCT02408393 Phase 3
35 Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection Active, not recruiting NCT00376597 Phase 3
36 WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Active, not recruiting NCT01659437 Phase 2, Phase 3
37 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Not yet recruiting NCT02927496 Phase 3
38 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3
39 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Not yet recruiting NCT02929134 Phase 3
40 Effects of an e-Home Based Symptom Management and Mindfulness Training Programme on QoL in Breast Cancer Survivors Not yet recruiting NCT02931864 Phase 3
41 Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer Terminated NCT00577317 Phase 3
42 Treatment of Lymphedema: Application of the Kinesio Taping Unknown status NCT00155220 Phase 2
43 Hyperbaric Oxygen Therapy Compared With Standard Therapy in Treating Chronic Arm Lymphedema in Patients Who Have Undergone Radiation Therapy for Cancer Unknown status NCT00077090 Phase 2
44 Therapeutical Assessment of Compression Armsleeves for Lymphatic Indications Unknown status NCT01318785 Phase 2
45 Breast Lymph Node Mapping Unknown status NCT01038908 Phase 2
46 Pycnogenol for the Treatment of Lymphedema Completed NCT00214032 Phase 2
47 Acupuncture for the Treatment of Chronic Lymphedema Completed NCT01003951 Phase 2
48 Horse Chestnut Seed Extract for Lymphedema Completed NCT00213928 Phase 2
49 The Effect of Combined Decongestive Therapy and Pneumatic Compression Pump on Body Image in Patients With Lymphedema Completed NCT02650297 Phase 1, Phase 2
50 A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer Completed NCT00827372 Phase 2

Search NIH Clinical Center for Lymphedema

Cochrane evidence based reviews: lymphedema

Genetic Tests for Lymphedema

Genetic tests related to Lymphedema:

id Genetic test Affiliating Genes
1 Lymphedema 29

Anatomical Context for Lymphedema

MalaCards organs/tissues related to Lymphedema:

39
Breast, Lymph Node, Skin, Endothelial, Testes, Bone, Nk Cells
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Lymphedema:
id Tissue Anatomical CompartmentCell Relevance
1 Heart Cardinal Veins Venous Endothelial Cells Potential therapeutic candidate, affected by disease

Publications for Lymphedema

Articles related to Lymphedema:

(show top 50) (show all 877)
id Title Authors Year
1
Clinical Treatment of Penile Fibrosis After Penoscrotal Lymphedema. ( 28083477 )
2017
2
Supermicrosurgical lymphaticovenous anastomosis for a patient with breast lymphedema secondary to breast cancer treatment. ( 28052379 )
2017
3
Differentiation of functional venous insufficiency and leg lymphedema complicated by functional venous insufficiency using subcutaneous tissue ultrasonography. ( 27987622 )
2017
4
Far infrared ray (FIR) therapy: An effective and oncological safe treatment modality for breast cancer related lymphedema. ( 28535427 )
2017
5
Therapeutic effects of hyaluronidase on acquired lymphedema using a newly developed mouse limb model. ( 28092183 )
2017
6
Platysma-sparing vascularized submental lymph node flap transfer for extremity lymphedema. ( 28058777 )
2017
7
Establishment of an Acquired Lymphedema Model in the Mouse Hindlimb: Technical Refinement and Molecular Characteristics. ( 28027235 )
2017
8
CCBE1 Mutation causing Sclerosing Cholangitis - Expanding the Spectrum of Lymphedema-Cholestasis Syndrome. ( 28073151 )
2017
9
Cutaneous polyarteritis nodosa localized to a region of lymphedema secondary to Streptococcus viridans cellulitis and multiple surgeries. ( 27862152 )
2017
10
Pediatric genital lymphedema with recurrent hydrocele and late-onset secondary skin changes. ( 27978613 )
2017
11
Surgical treatment of secondary lymphedema of the upper limb by stepped microsurgical lymphaticovenous anastomoses. ( 28083821 )
2017
12
Beckwith-Wiedemann Syndrome and Primary Lymphedema of the Lower Extremity. ( 27778389 )
2017
13
A Randomized Trial on the Effect of Exercise Mode on Breast Cancer-related Lymphedema. ( 27187092 )
2016
14
Effect of complete decongestive therapy and home program on health- related quality of life in post mastectomy lymphedema patients. ( 27145867 )
2016
15
Computed tomography-based quantitative assessment of lower extremity lymphedema following treatment for gynecologic cancer. ( 28028991 )
2016
16
Early Mandibular Distraction to Relieve Robin Severe Airway Obstruction in Two Siblings with Lymphedema-Distichiasis Syndrome. ( 27752211 )
2016
17
Dehydrated Human Amnion/Chorion Grafts May Accelerate the Healing of Ulcers on Free Flaps in Patients With Venous Insufficiency and/or Lymphedema. ( 27648116 )
2016
18
Cost of a lymphedema treatment mandate-10 years of experience in the Commonwealth of Virginia. ( 27590738 )
2016
19
A Comparison of the Quality of Life in Patients With Primary and Secondary Lower Limb Lymphedema: A Mixed-Methods Study. ( 27151079 )
2016
20
Breast Cancer-Related Lymphedema: Quality of Life after Lymph Node Transfer. ( 27219223 )
2016
21
Commentary on 'Haemodynamic Performance of Low strength Below knee Graduated Elastic Compression Stockings in Health, Venous Disease, and Lymphedema'. ( 27215549 )
2016
22
FOXC2 disease-mutations identified in lymphedema-distichiasis patients cause both loss and gain of protein function. ( 27276711 )
2016
23
Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema. ( 27182733 )
2016
24
Time to Re-consider a Gold Standard of Lymph Flow Imaging: Importance of Reliability to Detect Abnormal Lymphodynamics in Lymphedema Screening after Cancer Treatments. ( 28002242 )
2016
25
Giant Scrotal Hydrocele and Bilateral Leg Lymphedema as Clinical Manifestation of Chronic Lymphatic Filariasis. ( 27840360 )
2016
26
The effects of complex exercise on shoulder range of motion and pain for women with breast cancer-related lymphedema: a single-blind, randomized controlled trial. ( 28008557 )
2016
27
Long Term Results of Innovative Procedure in Surgical Management of Chronic Lymphedema. ( 27990192 )
2016
28
An unusual case of Corynebacterium striatum endocarditis in a patient with congenital lymphedema and rheumatic heart disease. ( 27751312 )
2016
29
Prevalence and Epidemiological Factors Involved in Cellulitis in Korean Patients With Lymphedema. ( 27152284 )
2016
30
Bioimpedance to screen for abdominal fat in patients with breast cancer treatment-related lymphedema. ( 27662273 )
2016
31
Correlates of Lymphedema in Women with Breast Cancer: a Case Control Study in Shiraz, Southern Iran. ( 27165213 )
2016
32
Pathophysiology of lymphedema-Is there a chance for medication treatment? ( 27566412 )
2016
33
Proteomic profiling of lymphedema development in mouse model. ( 27151289 )
2016
34
The Use of Noninvasive Imaging Techniques in the Assessment of Secondary Lymphedema Tissue Changes as Part of Staging Lymphedema. ( 27631582 )
2016
35
Perceived Symptom Experience in Head and Neck Cancer Patients with Lymphedema. ( 27617837 )
2016
36
Massive localized lymphedema of the thigh mimicking liposarcoma. ( 27920868 )
2016
37
Integration-free T cell-derived human induced pluripotent stem cells (iPSCs) from a patient with lymphedema-distichiasis syndrome (LDS) carrying an insertion-deletion complex mutation in the FOXC2 gene. ( 27346194 )
2016
38
The Impact of L-Dex(Ar) Measurements in Assessing Breast Cancer-Related Lymphedema as Part of Routine Clinical Practice. ( 27656420 )
2016
39
Applications of Platelet-Rich Plasma in Lymphedema. ( 27599222 )
2016
40
The need for preoperative baseline arm measurement to accurately quantify breast cancer-related lymphedema. ( 27154787 )
2016
41
Lymphedema Is a Disease of the Skin. ( 27631580 )
2016
42
Debunking Lymphedema Risk-Reduction Behaviors: Risky Conclusions. ( 27631581 )
2016
43
Shoulder Pain after Fall, Septic Shock, and Pyomyositis Associated with Breast Cancer Chemotherapy and Lymphedema. ( 27920709 )
2016
44
Relapse of Yellow Nail Syndrome with Pulmonary Lymphedema. ( 26781018 )
2016
45
Skin and Subcutaneous Tissue Ultrasonography Features in Breast Cancer-Related Lymphedema. ( 28018504 )
2016
46
Skeletal Scintigraphy in Radiation-Induced Fibrosis With Lymphedema. ( 28033224 )
2016
47
Cell-Assisted Lipotransfer Using Autologous Adipose-Derived Stromal Cells for Alleviation of Breast Cancer-Related Lymphedema. ( 27151914 )
2016
48
Distribution of Extracellular Fluid in Legs with Venous Edema and Lymphedema. ( 27603006 )
2016
49
Lymphedema: Presentation, Diagnosis, and Treatment. ( 27119937 )
2016
50
Economic Costs and Benefits of a Community-Based Lymphedema Management Program for Lymphatic Filariasis in Odisha State, India. ( 27573626 )
2016

Variations for Lymphedema

Expression for Lymphedema

Search GEO for disease gene expression data for Lymphedema.

Pathways for Lymphedema

GO Terms for Lymphedema

Cellular components related to Lymphedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lamellipodium membrane GO:0031258 8.62 PDPN PIEZO1

Biological processes related to Lymphedema according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.84 FOXC2 FOXL1 NRP2 SOX18
2 angiogenesis GO:0001525 9.83 FLT4 KDR NRP2 SOX18 VEGFC
3 positive regulation of angiogenesis GO:0045766 9.78 CCBE1 GATA2 KDR VEGFC
4 lung development GO:0030324 9.73 CCBE1 PDPN PROX1
5 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.72 FLT4 FOXC2 KDR NRP2 VEGFC
6 positive regulation of endothelial cell proliferation GO:0001938 9.65 FLT4 KDR NRP2 PROX1 VEGFC
7 positive regulation of endothelial cell migration GO:0010595 9.63 CCBE1 FLT4 FOXC2 KDR NRP2 PROX1
8 positive regulation of vascular endothelial growth factor production GO:0010575 9.61 CCBE1 FLT4
9 sprouting angiogenesis GO:0002040 9.61 CCBE1 FLT4
10 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.6 FOXC2 PROX1
11 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.59 FLT4 KDR
12 vasculature development GO:0001944 9.58 FLT4 SOX18
13 embryonic heart tube development GO:0035050 9.58 FOXC2 SOX18
14 cell fate determination GO:0001709 9.57 GATA2 PROX1
15 respiratory system process GO:0003016 9.55 CCBE1 FLT4
16 vascular endothelial growth factor signaling pathway GO:0038084 9.54 FLT4 KDR NRP2
17 venous blood vessel morphogenesis GO:0048845 9.52 CCBE1 PROX1
18 lymphatic endothelial cell differentiation GO:0060836 9.51 PROX1 SOX18
19 endocardium formation GO:0060214 9.49 PROX1 SOX18
20 positive regulation of lymphangiogenesis GO:1901492 9.46 CCBE1 VEGFC
21 lymph vessel development GO:0001945 9.35 CCBE1 FLT4 FOXC2 PROX1 SOX18
22 lymphangiogenesis GO:0001946 9.17 CCBE1 FLT4 FOXC2 PDPN PROX1 PTPN14
23 multicellular organism development GO:0007275 10.01 CCBE1 FOXC2 FOXL1 KDR NRP2 PDPN

Molecular functions related to Lymphedema according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.55 FOXC2 FOXL1 GATA2 PROX1 SOX18
2 growth factor binding GO:0019838 9.13 FLT4 KDR NRP2
3 vascular endothelial growth factor-activated receptor activity GO:0005021 8.8 FLT4 KDR NRP2

Sources for Lymphedema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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