MCID: LYM025
MIFTS: 53

Lymphedema malady

Genetic diseases, Immune diseases, Rare diseases, Eye diseases, Cardiovascular diseases, Skin diseases categories
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Summaries for Lymphedema

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MedlinePlus:33 Lymphedema is the name of a type of swelling. it happens when lymph builds up in your body's soft tissues. lymph is a fluid that contains white blood cells that defend against germs. it can build up when the lymph system is damaged or blocked. it usually happens in the arms or legs. causes of lymphedema include infection cancer scar tissue from radiation therapy or surgical removal of lymph nodes inherited conditions in which lymph nodes or vessels are absent or abnormal treatment can help control symptoms. it includes exercise, compression devices, skin care, and massage. nih: national cancer institute

MalaCards based summary: Lymphedema, also known as lymphatic edema, is related to hydrops fetalis and angiosarcoma. An important gene associated with Lymphedema is FLT4 (fms-related tyrosine kinase 4), and among its related pathways are Angiogenesis and VEGF Pathway. Affiliated tissues include breast, lymph node and skin, and related mouse phenotypes are cardiovascular system and normal.

CDC:3 Lymphatic filariasis, considered globally as a neglected tropical disease, is a parasitic disease caused by microscopic, thread-like worms. The adult worms only live in the human lymph system. The lymph system maintains the body's fluid balance and fights infections. Lymphatic filariasis is spread from person to person by mosquitoes.

Wikipedia:65 Lymphedema (lymphoedema in British English), also known as lymphatic obstruction, is a condition of... more...

Aliases & Classifications for Lymphedema

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Lymphedema, Aliases & Descriptions:

Name: Lymphedema 30 8 10 44 33 62
Lymphatic Edema 8 62
 
Lymphoedema Nos 8


Classifications:



External Ids:

Disease Ontology8 DOID:4977
MeSH34 D008209
NCIt39 C3207

Related Diseases for Lymphedema

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Diseases in the Hereditary Lymphedema family:

lymphedema Hereditary Lymphedema Type Ii
Lymphedema, Congenital Hereditary Lymphedema Ic
Lymphedema, Hereditary, Id Lymphedema, Hereditary, Ia
Lymphedema, Hereditary, Ib

Diseases related to Lymphedema via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1hydrops fetalis30.8FLT4
2angiosarcoma30.6FLT4, VEGFC
3mongolian spot30.5SOX18, FOXC2
4lymphedema, congenital30.2VEGFC, FLT4, FOXC2
5klippel-trenaunay syndrome30.1SOX18, FLT4, FOXC2
6kaposi's sarcoma29.8VEGFC, FLT4
7breast cancer10.9
8hereditary lymphedema10.7
9lymphedema-distichiasis syndrome10.7
10lymphangiosarcoma10.6
11hereditary lymphedema type ii10.6
12yellow nail syndrome10.5
13elephantiasis10.5
14hennekam syndrome10.4
15aagenaes syndrome10.4
16lymphedema, hereditary, ia10.4
17lymphedema tarda10.4
18hypotrichosis-lymphedema-telangiectasia syndrome10.4
19obesity10.3
20microcephaly10.3
21lipedema10.3
22erysipelas10.3
23breast reconstruction10.3
24filariasis10.3
25microcephaly with or without chorioretinopathy, lymphedema, or mental retardation10.3
26chorioretinitis10.2
27chylous ascites10.2
28dahlberg borer newcomer syndrome10.2
29lymphedema and cerebral arteriovenous anomaly10.2
30hereditary lymphedema ic10.2
31hennekam lymphangiectasia-lymphedema syndrome 110.2
32lymphangitis10.2
33cholestasis10.2
34hypotrichosis10.2
35melanoma10.2
36lymphedema, microcephaly and chorioretinopathy syndrome10.2
37cervical cancer10.1
38tuberous sclerosis10.1
39cervicitis10.1
40turner syndrome10.1
41mental retardation10.1
42emberger syndrome10.1
43hennekam lymphangiectasia-lymphedema syndrome 210.1
44podoconiosis10.1
45arachnoiditis10.1
46protein-losing enteropathy10.1
47lymphangioleiomyomatosis10.1
48noonan syndrome10.1
49cellulitis10.1
50sarcoma10.1

Graphical network of the top 20 diseases related to Lymphedema:



Diseases related to lymphedema

Symptoms for Lymphedema

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Drugs & Therapeutics for Lymphedema

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Drug clinical trials:

Search ClinicalTrials for Lymphedema

Search NIH Clinical Center for Lymphedema

Genetic Tests for Lymphedema

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Anatomical Context for Lymphedema

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MalaCards organs/tissues related to Lymphedema:

32
Breast, Lymph node, Skin, Endothelial, Bone, Brain, Smooth muscle, Colon, Liver, Prostate, Testes, Myeloid, Monocytes, Nk cells, T cells, B cells, Neutrophil, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Lymphedema:
id TissueAnatomical CompartmentCell Relevance
1 HeartCardinal VeinsVenous Endothelial Cells Potential therapeutic candidate, affected by disease

Animal Models for Lymphedema or affiliated genes

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MGI Mouse Phenotypes related to Lymphedema:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.4FOXC2, FLT4, SOX18, VEGFC
2MP:00028738.2SOX18, FLT4, FOXC2, CCBE1, GJC2
3MP:00053788.0PTPN14, SOX18, FLT4, FOXC2, KIF11
4MP:00053767.4VEGFC, PTPN14, SOX18, FLT4, FOXC2, CCBE1
5MP:00053877.0GJC2, VEGFC, PTPN14, SOX18, FLT4, FOXC2
6MP:00107686.9VEGFC, SOX18, FLT4, FOXC2, CCBE1, KIF11

Publications for Lymphedema

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Articles related to Lymphedema:

(show top 50)    (show all 720)
idTitleAuthorsYear
1
Supermicrosurgical anastomosis of superficial lymphatic vessel to deep lymphatic vessel for a patient with cellulitis-induced chronic localized leg lymphedema. (25197031)
2014
2
Malpractice leading to secondary lymphedema after radical mastectomy: case report. (24415992)
2013
3
A novel complex insertion-deletion mutation in the FOXC2 gene in a Japanese patient with Lymphedema-Distichiasis Syndrome. (23747797)
2013
4
Penile and sexual rehabilitation in a patient with lymphedema of the penis. (23485846)
2013
5
Axillary reverse mapping using fluorescence imaging is useful for identifying the risk group of postoperative lymphedema in breast cancer patients undergoing sentinel node biopsies. (24310418)
2013
6
Massive localized lymphedema of the male external genitalia: a clinicopathologic study of 6 cases. (22995331)
2013
7
The effects of pole walking on arm lymphedema and cardiovascular fitness in women treated for breast cancer: a pilot and feasibility study. (24175620)
2013
8
Eyelid lymphedema following neck dissection and radiotherapy. (23446298)
2013
9
Therapeutic strategy for lower limb lymphedema and lymphatic fistula after resection of a malignant tumor in the hip joint region: A case report. (23908155)
2013
10
Optimizing surgical treatment of lymphedema. (23246031)
2013
11
Re-evaluation of qualitative lymphangioscintigraphic findings in secondary lower extremity lymphedema. (24374366)
2013
12
Congenital Segmental Lymphedema in Tuberous Sclerosis Complex With Associated Subependymal Giant Cell Astrocytomas Treated with Mammalian Target of Rapamycin Inhibitors. (24056156)
2013
13
Peripheral venous angle plasty: a new lymphovenous anastomosis technique for lower extremity lymphedema. (22743945)
2012
14
Axillary reverse mapping (ARM): initial results of phase II trial in preventing lymphedema after lymphadenectomy. (23018481)
2012
15
Neutrophilic dermatosis on postmastectomy lymphedema. (22677124)
2012
16
Liposuction normalizes - in contrast to other therapies - lymphedema-induced adipose tissue hypertrophy. (23283813)
2012
17
Localized xanthomas associated with primary lymphedema. (22256994)
2012
18
Voices from the shadows: living with lymphedema. (21558848)
2012
19
Yellow nail syndrome: treatment of lymphedema using low pressure compression. (22416910)
2012
20
Antegrade and retrograde lymphatico-venous anastomosis for cancer-related lymphedema with lymphatic valve dysfuction and lymphatic varix. (22903404)
2012
21
Congenital chylous ascites and lymphedema in Down's syndrome. (22418947)
2012
22
Current views on diagnostic approach and treatment of lymphedema. (22269614)
2012
23
Complex Decongestive Physiotherapy Treats Skin Changes like Hyperkeratosis Caused by Lymphedema. (23259083)
2012
24
Scale-independent stiffness measurement of upper limbs with lymphedema by a circular compression. (23366313)
2012
25
Quantification of lymphedema in a rat model by 3D-active contour segmentation by magnetic resonance imaging. (22416909)
2012
26
Prenatal diagnosis of Milroy's primary congenital lymphedema. (22795109)
2012
27
Nursing education on lymphedema self-management and self-monitoring in a South African oncology clinic. (22288209)
2011
28
Prediction of treatment outcome with bioimpedance measurements in breast cancer related lymphedema patients. (22506192)
2011
29
Gene expression in Graves' ophthalmopathy and arm lymphedema: similarities and differences. (21510802)
2011
30
Surgical management of lymphedema: past, present, and future. (22066746)
2011
31
Cutaneous angiosarcoma in chronic lymphedema: secondary to filariasis. (23024552)
2011
32
Giant scrotal lymphedema as unique onset sign of muscle-invasive bladder cancer. The risk of a misdiagnosis. (21826882)
2011
33
Lymphedema in patients with head and neck cancer. (21186146)
2011
34
Tissue fluid pressure and flow during pneumatic compression in lymphedema of lower limbs. (21688976)
2011
35
Impact of aggressive decongestion on the maintenance phase in combined physical therapy for lower extremity lymphedema. (23555469)
2011
36
Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial. (21148134)
2010
37
Rare association of immunoglobulin A nephropathy and lymphedema-distichiasis syndrome. (20124880)
2010
38
Cutaneous tumors, massive lymphadenopathy, and secondary lymphedema in a 16-year-old boy--quiz case. African/endemic Kaposi sarcoma (KS): lymphadenopathic form. (18794470)
2008
39
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
40
Stewart-Treves syndrome as a rare complication of a hereditary lymphedema. (15061047)
2004
41
Kaposiform hemangioendothelioma associated with Milroy's disease (primary hereditary lymphedema). (12861592)
2003
42
Quantification of lymphatic function for investigation of lymphedema: depot clearance and rate of appearance of soluble macromolecules in blood. (11884490)
2002
43
Lymphedema-lymphangiectasia-mental retardation (Hennekam) syndrome: a review. (12376947)
2002
44
Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3. (11175851)
2001
45
Lymphedema-distichiasis syndrome: report of a case and review. (10086462)
1999
46
Lymphangiosarcoma of arm after chronic lymphedema: a rare long-term complication after radical mastectomy in breast cancer patients. Case report and overview. (8503088)
1993
47
Hereditary lymphedema in Hereford cattle. (2039787)
1991
48
Congenital hereditary lymphedema in the pig. (642582)
1978
49
The pathogenesis of congenital hereditary lymphedema in the pig. (642583)
1978
50
Lymphedema tarda. (946512)
1976

Variations for Lymphedema

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Expression for genes affiliated with Lymphedema

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Expression patterns in normal tissues for genes affiliated with Lymphedema

Search GEO for disease gene expression data for Lymphedema.

Pathways for genes affiliated with Lymphedema

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Compounds for genes affiliated with Lymphedema

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GO Terms for genes affiliated with Lymphedema

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Biological processes related to Lymphedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sprouting angiogenesisGO:0020409.7CCBE1, FLT4
2embryonic heart tube developmentGO:0350509.5FOXC2, SOX18
3vasculature developmentGO:0019449.5FLT4, SOX18
4positive regulation of endothelial cell migrationGO:0105959.2FLT4, FOXC2, CCBE1
5vascular endothelial growth factor receptor signaling pathwayGO:0480108.9FOXC2, FLT4, VEGFC
6lymphangiogenesisGO:0019468.5CCBE1, FOXC2, FLT4, SOX18, PTPN14

Molecular functions related to Lymphedema according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionGO:0010779.6FOXC2, SOX18

Products for genes affiliated with Lymphedema

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Sources for Lymphedema

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3CDC
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23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
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28IUPHAR
29KEGG
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35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet