MCID: LYM110
MIFTS: 51

Lymphedema, Hereditary, Ia malady

Categories: Genetic diseases, Rare diseases, Immune diseases

Aliases & Classifications for Lymphedema, Hereditary, Ia

About this section

Aliases & Descriptions for Lymphedema, Hereditary, Ia:

Name: Lymphedema, Hereditary, Ia 52
Milroy Disease 23 48 24 25 70 68
Nonne-Milroy Lymphedema 11 48 25 70
Hereditary Lymphedema Type I 48 25 27
Hereditary Lymphedema 11 48 13
Milroy's Disease 11 48 25
Hereditary Lymphedema, Type I 23 24
Primary Congenital Lymphedema 48 70
Milroy Congenital Lymphedema 23 24
Congenital Hereditary Lymphedema 48
Congenital Familial Lymphedema 25
Hereditary Lymphoedema, Type I 24
Milroy Congenital Lymphoedema 24
 
Lymphedema Hereditary Type Ia 70
Congenital Primary Lymphedema 48
Lymphedema, Hereditary, 1a 70
Lymphedema, Hereditary I 12
Hereditary Lymphedema 1 48
Lymphedema Early-Onset 70
Early Onset Lymphedema 48
Nonne-Milroy Syndrome 48
Nonne-Milroy Disease 48
Nonne’s Syndrome 48
Cardiac Lymphoma 68
Lmph1a 70
Pcl 70

Characteristics:

HPO:

64
lymphedema, hereditary, ia:
Inheritance: autosomal dominant inheritance
Onset and clinical course: congenital onset

GeneReviews:

23
Penetrance: approximately 85%-90% of individuals who have a pathogenic variant in flt4 develop lower-limb lymphedema by age three years; conversely, 10%-15% of individuals with an flt4 pathogenic variant are clinically unaffected. ...


Classifications:



External Ids:

OMIM52 153100
Disease Ontology11 DOID:0050580
ICD9CM32 757.0
MedGen37 C1704423
MeSH39 D008209
UMLS68 C1313885

Summaries for Lymphedema, Hereditary, Ia

About this section
OMIM:52 Hereditary primary lymphedema is caused by anatomic or functional defects in the lymphatic system, resulting in chronic... (153100) more...

MalaCards based summary: Lymphedema, Hereditary, Ia, also known as milroy disease, is related to hereditary lymphedema type ii and plasma cell leukemia, and has symptoms including hydrocele testis, hemangioma and abnormality of the amniotic fluid. An important gene associated with Lymphedema, Hereditary, Ia is FLT4 (Fms Related Tyrosine Kinase 4), and among its related pathways are Signaling events mediated by VEGFR1 and VEGFR2 and VEGFR3 signaling in lymphatic endothelium. Affiliated tissues include legs, skin and testis, and related mouse phenotypes are adipose tissue and digestive/alimentary.

Disease Ontology:11 A lymphedema commonly located in legs, caused by congenital abnormalities in the lymphatic system.

UniProtKB/Swiss-Prot:70 Lymphedema, hereditary, 1A: A chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.

Genetics Home Reference:25 Milroy disease is a condition that affects the normal function of the lymphatic system. The lymphatic system produces and transports fluids and immune cells throughout the body. Impaired transport with accumulation of lymph fluid can cause swelling (lymphedema). Individuals with Milroy disease typically have lymphedema in their lower legs and feet at birth or develop it in infancy. The lymphedema typically occurs on both sides of the body and may worsen over time.

NIH Rare Diseases:48 Milroy disease is a lymphatic disease that causes swelling (lymphedema) in the lower legs and feet. Lymphedema is usually present at birth or develops in infancy. It typically occurs on both sides of the body and can worsen over time. Other symptoms may include accumulation of fluid in the scrotum in males (hydrocele), upslanting toenails, deep creases in the toes, wart-like growths, prominent leg veins, and/or cellulitis. Milroy disease is sometimes caused by changes (mutations) in the FLT4 gene and is inherited in an autosomal dominant manner. In many cases, the cause remains unknown. Treatment may include lymphedema therapy to improve function and alleviate symptoms. Last updated: 1/29/2015

GeneReviews for NBK1239

Related Diseases for Lymphedema, Hereditary, Ia

About this section

Diseases in the Lymphedema family:

Lymphedema, Hereditary, Ic Lymphedema, Hereditary, Id
lymphedema, hereditary, ia Lymphedema, Hereditary, Ib
Congenital Lymphedema Hereditary Lymphedema Type Ii

Diseases related to Lymphedema, Hereditary, Ia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary lymphedema type ii11.9
2plasma cell leukemia11.7
3lymphedema, hereditary, ic11.4
4congenital lymphedema11.2
5lymphedema-distichiasis syndrome11.2
6lymphedema, hereditary, id11.0
7yellow nail syndrome10.8
8lymphedema10.4
9lymphocytes absent10.1FLT4, PROX1
10silicosiderosis10.1FLT4, PROX1
11congenital cystic eye multiple ocular and intracranial anomalies10.0FLT4, PROX1
12hyperlucent lung10.0FLT4, PROX1
13distichiasis9.9
14epidermolysis bullosa9.9FLT4, PROX1
15chikungunya9.9FLT4, PROX1
16personality disorder9.9
17lymphangiosarcoma9.8
18gummatous syphilis9.8FLT4, FOXC2, GJC2
19calcaneonavicular coalition9.7FLT4, VEGFC
20lung cancer9.7
21gastric cancer9.7
22leukemia9.7
23antisocial personality disorder9.7
24neuroendocrine tumor9.7
25post-traumatic stress disorder9.7
26endotheliitis9.7
27osteoporotic fracture9.7
28adie pupil9.6FOXC2, SOX18
29ocular melanoma9.6FLT4, PROX1
30cholestasis9.6
31obstructive jaundice9.6
32elephantiasis9.6
33hemangioendothelioma9.6
34hydrops fetalis9.6
35kaposiform hemangioendothelioma9.6
36orofaciodigital syndrome vii9.6FLT4, PROX1, VEGFC
37intracranial hemorrhage in brain cerebrovascular malformations9.5FLT4, PROX1, VEGFC
38miyoshi muscular dystrophy 29.4FLT4, FOXC2, SOX18
39retinitis pigmentosa 319.4FLT4, FOXC2, SOX18
40sleep apnea9.4FOXC2, GJC2, SOX18
41ostertagiasis9.4FOXC2, GJC2, SOX18
42leydig cell tumor9.2FLT4, GJC2, PROX1, VEGFC
43pediatric infratentorial ependymoma9.2FLT4, FOXC2, GJC2, VEGFC
44lymphoid leukemia8.1FLT4, FOXC2, GJC2, PROX1, SOX18, VEGFC

Graphical network of the top 20 diseases related to Lymphedema, Hereditary, Ia:



Diseases related to lymphedema, hereditary, ia

Symptoms & Phenotypes for Lymphedema, Hereditary, Ia

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Symptoms by clinical synopsis from OMIM:

153100

Clinical features from OMIM:

153100

Human phenotypes related to Lymphedema, Hereditary, Ia:

 64 (show all 8)
id Description HPO Frequency HPO Source Accession
1 hydrocele testis64 HP:0000034
2 hemangioma64 HP:0001028
3 abnormality of the amniotic fluid64 HP:0001560
4 abnormality of the nail64 HP:0001597
5 nonimmune hydrops fetalis64 HP:0001790
6 predominantly lower limb lymphedema64 HP:0003550
7 hypoplasia of lymphatic vessels64 HP:0003759
8 hyperkeratosis over edematous areas64 HP:0007448

UMLS symptoms related to Lymphedema, Hereditary, Ia:


massive edema, pain of lymph node

MGI Mouse Phenotypes related to Lymphedema, Hereditary, Ia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.0FLT4, FOXC2, PROX1, SOX18
2MP:00053819.0FLT4, FOXC2, PROX1, SOX18
3MP:00053858.4FLT4, FOXC2, PROX1, SOX18, VEGFC
4MP:00053877.9FLT4, FOXC2, GJC2, PROX1, SOX18, VEGFC
5MP:00107687.9FLT4, FOXC2, GJC2, PROX1, SOX18, VEGFC
6MP:00028737.7FLT4, FOXC2, GJC2, PROX1, SOX18

Drugs & Therapeutics for Lymphedema, Hereditary, Ia

About this section

Drugs for Lymphedema, Hereditary, Ia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
DicyclomineapprovedPhase 4477-19-03042
Synonyms:
(1,1'-Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester
(BICYCLOHEXYL)-1-CARBOXYLIC ACID, 2-(DIETHYLAMINO)ETHYL ESTER, HYDROCHLORIDE
(Bicyclohexyl)-1-carboxylic acid, 2-(diethylamino)ethyl ester
.beta.-Diethylaminoethyl 1-cyclohexylcyclohexanecarboxylate hydrochloride
.beta.-Diethylaminoethyl-1-cyclohexylhexahydrobenzoate hydrochloride
1-Cyclohexylcyclohexanecarboxylic acid 2-(diethylamino)ethyl ester
104959-55-9
2-(Diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate
2-(diethylamino)ethyl 1,1'-bi(cyclohexyl)-1-carboxylate
2-(diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
2-diethylaminoethyl 1-cyclohexylcyclohexane-1-carboxylate
2-diethylaminoethyl 1-cyclohexylcyclohexane-1-carboxylate hydrochloride
67-92-5 (hydrochloride)
77-19-0
856995-49-8
AB00053456
AC1L1F1K
AC1Q2ZDW
AC1Q2ZDX
Atumin
BPBio1_000193
BRD-K68507560-003-05-5
BSPBio_000175
BSPBio_002175
Bentomine
Bentyl hydrochloride
Bentylol
Bentylol hydrochloride
Bicyclohexyl-1-carbonsaeure-2'diethylaminoethylester
Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl ester
C06951
C19H35NO2
CAS-67-92-5
CHEBI:265774
CHEBI:4514
CHEMBL1123
CID3042
Cyclohexanecarboxylic acid, 1-cyclohexyl-, 2-(diethylamino)ethyl ester
D07820
DB00804
DICYCLOMINE
Di-syntramine
Dicicloverina
Dicicloverina [INN-Spanish]
Dicyclomine Hcl
Dicycloverin
Dicycloverin hydrochloride
Dicycloverine
Dicycloverine (INN)
Dicycloverine [INN:BAN]
Dicycloverinum
Dicycloverinum [INN-Latin]
Dicymine
Dicymine (TN)
Diethylaminocarbethoxybicyclohexyl hydrochloride
Diocyl
 
Diocyl hydrochloride
DivK1c_000162
Dyspas
EINECS 201-009-4
Formulex
GU8471000
HSDB 3058
IDI1_000162
InChI=1/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
J.L. 998
KBio1_000162
KBio2_001414
KBio2_003982
KBio2_006550
KBio3_001395
KBioGR_001057
KBioSS_001414
Kolantyl hydrochloride
L000680
LS-177325
LS-56640
Lopac-D-7909
Lopac0_000432
Mamiesan
Merbentyl
MolPort-001-832-617
NCGC00015368-01
NCGC00015368-02
NCGC00015368-08
NCGC00016300-01
NCGC00024386-03
NINDS_000162
NIOSH/GU8471000
NSC404381
Oxityl-P
Prestwick0_000048
Prestwick1_000048
Prestwick2_000048
Prestwick3_000048
Procyclomin
SPBio_000440
SPBio_002096
Sawamin
Spasmoban
Spectrum2_000590
Spectrum3_000388
Spectrum4_000509
Spectrum5_000873
Spectrum_000934
T472
UNII-4KV4X8IF6V
WLN: L6TJ A- AL6TJ AVO2N2&2 &GH
Wyovin
Wyovin hydrochloride
[1,1'-Bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester
[Bicyclohexyl]-1-carboxylic acid, 2- (diethylamino)ethyl ester hydrochloride
[Bicyclohexyl]-1-carboxylic acid, 2-(diethylamino)ethyl ester hydrochloride
dicyclomine
2
Doxylamineapproved, vet_approvedPhase 46562-10-7, 469-21-63162
Synonyms:
2-(alpha-(2-(Dimethylamino)ethoxy)-alpha-methylbenzyl)pyridine
2-Dimethylaminoethoxyphenylmethyl-2-picoline
469-21-6
5-21-03-00508 (Beilstein Handbook Reference)
AB00053466
AC-15949
AC1L1FB8
Alsadorm
BPBio1_000103
BRD-A44008656-036-05-0
BRN 0230379
BSPBio_000093
BSPBio_001938
C17H22N2O
CHEBI:51380
CHEMBL1004
CID3162
D004319
D07878
DB00366
Decapryn
Decapryn (TN)
Decapryn succinate
DivK1c_000841
Dossilamina
Dossilamina [DCIT]
Doxilamina
Doxilminio
Doxilminio [INN-Spanish]
Doxylamine (INN)
Doxylamine [INN:BAN]
Doxylamine hydrogen succinate
Doxylamine succinate
Doxylamine succinate (1:1)
Doxylaminum
Doxylaminum [INN-Latin]
EINECS 207-414-2
HSDB 5184
 
IDI1_000841
KBio1_000841
KBio2_001494
KBio2_004062
KBio2_006630
KBio3_001158
KBioGR_001135
KBioSS_001494
L001076
LS-127
Lopac0_000348
Mereprine
MolPort-005-935-542
N,N-Dimethyl-2-(1-phenyl-1-(2-pyridinyl)ethoxy)ethanamine
N,N-dimethyl-2-(1-phenyl-1-pyridin-2-ylethoxy)ethanamine
N,N-dimethyl-2-[(1-phenyl-1-pyridin-2-ylethyl)oxy]ethanamine
N,N-dimethyl-2-[1-phenyl-1-(pyridin-2-yl)ethoxy]ethanamine
NCGC00021147-08
NCGC00089789-02
NCGC00089789-04
NCGC00089789-05
NCI C60684
NINDS_000841
Phenyl-2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether
Prestwick0_000027
Prestwick1_000027
Prestwick2_000027
Prestwick3_000027
SPBio_000130
SPBio_002014
STL018676
Spectrum2_000115
Spectrum3_000409
Spectrum4_000528
Spectrum5_000949
Spectrum_001014
UNII-95QB77JKPL
doxilamina
doxylamine
3
HistamineapprovedPhase 4103475614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
4
Histamine PhosphateapprovedPhase 4103351-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
 
EINECS 200-118-4
H0147
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
5
Folic Acidapproved, nutraceutical, vet_approvedPhase 4427959-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
Folsaeure
 
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
6
Pyridoxalapproved, nutraceuticalPhase 418566-72-81050
Synonyms:
2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine
3-Hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde
 
3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde
3-hydroxy-5-(hydroxymethyl)-2-methylpyridine-4-carboxaldehyde
Piridoxal
Pyridoxal
Pyridoxaldehyde
7
Pyridoxineapproved, nutraceutical, vet_approvedPhase 418665-23-61054
Synonyms:
(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate
12001-78-4
2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-di(hydroxymethyl)pyridine
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin
2-Methyl-3-hydroxy-4,5-dihydroxymethyl-pyridin [German]
2-Methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-Methyl-4,5-bis(hydroxymethyl)-3-hydroxypyridine
2-methyl-3-hydroxy-4,5-bis(hydroxy-methyl) pyridine
2-methyl-3-hydroxy-4,5-dihydroxymethylpyridine
2-methyl-4,5-dimethylol-pyridin-3-ol
2B3E07D2-E4CC-4CC5-B085-6070BA01F9F0
3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
3-Hydroxy-2-Picoline-4,5-dimethanol
3-Hydroxy-4,5-dihydroxymethyl-2-methylpyridine hydrochloride
3-Hydroxy-4,5-dimethylol-.alpha.-picoline hydrochloride
3-Hydroxy-4,5-dimethylol-alpha-picoline
3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride
3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine
4,5-Bis(hydroxymethyl)-2-methyl-3-pyridinol
4,5-Bis(hydroxymethyl)-2-methylpyridin-3-ol hydrochloride
4,5-bis(hydroxymethyl)-2-methyl-3-pyridinol hydrochloride
4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol
4,5-bis(hydroxymethyl)-2-methylpyridine-3-ol
4-Deoxypyridoxine 5'-phosphate
47862_SUPELCO
5-Hydroxy-6-methyl-3,4-pyridinedicarbinol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol
5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride
5-Hydroxy-6-methyl-3,4-pyridinedimethanol, hydrochloride
58-56-0
58-56-0 (HCL)
58-56-0 (hydrochloride)
65-23-6
65-23-6 (Parent)
8059-24-3
85078-23-5
AC-12024
AC-14512
AC-907/25014218
AC1L1AMH
AC1L1LMI
AC1L2XK2
AC1Q22HP
AC1Q2G66
AC1Q3F63
AI3-19016
AIDS-006784
AIDS006784
AR-1A6363
AR-1J1632
Adermin hydrochloride
Adermine
Adermine hydrochloride
Aderomine hydrochloride
Aderoxin
Aderoxine
Alestrol
BB_NC-0050
BIDD:PXR0180
BPBio1_000646
BSPBio_000586
Becilan
Beesix
Benadon
Bonasanit
C00314
C8H11NO3
CAS-58-56-0
CBDivE_015627
CCRIS 1903
CHEBI:16709
CHEBI:30961
CHEMBL1200756
CHEMBL1364
CID104817
CID1054
CID6019
CPD0-1221
Campoviton 6
Cernevit-12
D02179
D025101
D08454
DB00165
EINECS 200-386-2
EINECS 200-603-0
EINECS 232-503-8
Godabion
Gravidox
HMS1569N08
HMS2093L07
HSDB 1212
Hexa-Betalin
Hexa-Betalin (R)
Hexa-betalin (TN)
Hexabetalin
Hexabione hydrochloride
 
Hexavibex
Hexermin
Hexermine
Hexobion
Hydoxin
I02-1897
I02-2297
KST-1A8556
LS-134393
LS-187072
LS-2332
MLS001074329
MLS002153915
MolPort-002-137-856
MolPort-002-319-991
MolPort-005-933-330
NCGC00016261-01
NCGC00164317-01
NCGC00180946-01
NSC 36225
NSC36225
NSC36225 (HCL)
Nestrex
Oprea1_061614
P0561
P4722_SIAL
P5669_SIGMA
P6280_SIGMA
P8666_SIGMA
P9755_SIAL
PN
PN HCl
PYRIDOXINE HYDROCHLORIDE
PYRIDOXINE HYDROCHLORIDE, U.S.P.
Paxadon
Piridossina
Piridossina [DCIT]
Piridoxina
Piridoxina [INN-Spanish]
Prestwick0_000623
Prestwick1_000623
Prestwick2_000623
Prestwick3_000623
Prestwick_925
Pydox
Pyridipca
Pyridox
Pyridoxin
Pyridoxin hydrochloride
Pyridoxine
Pyridoxine (INN)
Pyridoxine HCl
Pyridoxine Hydrochloride (B6)
Pyridoxine [INN:BAN]
Pyridoxine chloride
Pyridoxine hydrochloride (JP15/USP)
Pyridoxine hydrochloride [USAN:JAN]
Pyridoxine hydrogen chloride
Pyridoxine monohydrochloride
Pyridoxine, hydrochloride
Pyridoxine-HCl Microencapsulated
Pyridoxinium chloride
Pyridoxinum
Pyridoxinum [INN-Latin]
Pyridoxinum hydrochloricum
Pyridoxinum hydrochloricum (Hungarian)
Pyridoxol
Pyridoxol hydrochloride
Pyridoxol, hydrochloride
Pyridoxolum
Rodex
Rodex (R)
Rodex TD
SMP2_000230
SMR000674613
SPBio_002805
STK177324
STOCK1N-08684
Spondylonal
Tex Six T.R.
TimTec1_000657
UNII-68Y4CF58BV
UNII-KV2JZ1BI6Z
Vitamin B 6
Vitamin B6
Vitamin B6-hydrochloride
Vitamin V6
Vitamin V6 (TN)
Vitamin-?B6
Vitamin-?B6 hydrochloride
Vitaped
WLN: T6NJ B1 CQ D1Q E1Q &GH
ZINC00049154
ZINC21983293
bmse000288
c1302
component of Alestrol
nchembio.93-comp1
pyridoxine
vitamin B6
8Neurotransmitter AgentsPhase 4, Phase 317734
9ParasympatholyticsPhase 41050
10VitaminsPhase 45095
11Peripheral Nervous System AgentsPhase 422776
12Vitamin B ComplexPhase 44229
13Trace ElementsPhase 45802
14AntiemeticsPhase 43888
15Muscarinic AntagonistsPhase 41134
16Vitamin B 6Phase 4186
17Cholinergic AntagonistsPhase 41658
18Autonomic AgentsPhase 49774
19MicronutrientsPhase 45802
20Dicyclomine, doxylamine, pyridoxine drug combinationPhase 44
21Cholinergic AgentsPhase 43846
22Histamine H1 AntagonistsPhase 4782
23Histamine AntagonistsPhase 4946
24Gastrointestinal AgentsPhase 48109
25FolateNutraceuticalPhase 44279
26Vitamin B9NutraceuticalPhase 44279
27
Paroxetineapproved, investigationalPhase 322661869-08-743815
Synonyms:
(-)-(3S,4R)-4-(P-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine
(-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine
(-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-methylenedioxy)phenoxy)methyl)piperidine
(-)-Paroxetine
(-)-trans-4-(4-Fluorophenyl)-3-(3,4-methylenedioxyphenoxymethyl)piperidine
(-)-trans-4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]-piperidine
(3S,4R)-3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine
(3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine
(3S-trans)-3-((1,3-Benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
(3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine
(3S-trans)-3-[(1,3-Benzodioxol-5-yl-oxy)methyl]-4-(4-fluorophenyl)piperidine
110429-35-1
3-(Benzo[1,3]Dioxol-5-Yl-Oxymethyl)-4-(4-Fluoro-Phenyl)-Piperidine Hydrochloride
61869-08-7
63952-24-9
64006-44-6 (maleate)
78246-49-8 (hydrochloride)
AB00514724
AC1L2AKL
AC1Q1H18
AC1Q4LV6
Aropax
BIDD:GT0673
BPBio1_000949
BRD-K37991163-003-02-7
BRL 29060
BRL-29060
BSPBio_000861
C07415
C19H20FNO3
CHEBI:7936
CHEMBL490
CID43815
Casbol
D02362
DB00715
DivK1c_006884
FG 7051
FG-7051
FT-0085087
Frosinor
 
HMS2090H05
I14-7752
KBio1_001828
KBio2_002232
KBio2_004800
KBio2_007368
KBioSS_002232
LS-114249
MolPort-003-849-791
Motivan
NCGC00025355-02
NCGC00025355-03
NCGC00025355-04
NCGC00025355-05
NCGC00025355-06
NCGC00025355-07
NCGC00025355-08
NNC-20-7051
Paroxetina
Paroxetina [INN-Spanish]
Paroxetine
Paroxetine (TN)
Paroxetine (USP/INN)
Paroxetine Hcl
Paroxetine [USAN:INN:BAN]
Paroxetinum
Paroxetinum [INN-Latin]
PaxPar
Paxetil
Paxil
Paxil CR
Pexeva
Prestwick3_000851
Seroxat
Seroxat CR
SpecPlus_000788
Spectrum5_001665
Spectrum_001752
TL8003967
UNII-41VRH5220H
[3H]Paroxetine
paroxetine
28Psychotropic DrugsPhase 36279
29Serotonin Uptake InhibitorsPhase 31570
30Serotonin AgentsPhase 33102
31
SerotoninPhase 3356650-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
32Neurotransmitter Uptake InhibitorsPhase 33464
33Antidepressive AgentsPhase 32666
34Antidepressive Agents, Second-GenerationPhase 31287
35Cytochrome P-450 CYP2D6 InhibitorsPhase 3716
36Cytochrome P-450 Enzyme InhibitorsPhase 33822
37
Ethanolapproved204364-17-5702
Synonyms:
(C6-C9)Alkyl alcohol
02483_FLUKA
02851_FLUKA
02853_FLUKA
02854_FLUKA
02855_FLUKA
02856_FLUKA
02856_SIAL
02857_FLUKA
02857_SIAL
02858_FLUKA
02858_SIAL
02860_FLUKA
02865_FLUKA
02865_SIAL
02870_FLUKA
02870_SIAL
02875_FLUKA
02877_FLUKA
02878_FLUKA
02882_FLUKA
02882_SIAL
02883_FLUKA
02884_FLUKA
02890_FLUKA
02890_SIAL
02891_FLUKA
02891_SIAL
1-Hydroxyethane
100C.NPA
121182-78-3
187380_ALDRICH
187380_SIAL
24102_RIEDEL
24102_SIAL
24103_RIEDEL
24103_SIAL
24105_RIEDEL
24105_SIAL
24106_RIEDEL
24106_SIAL
24194_RIEDEL
24194_SIAL
245119_ALDRICH
245119_SIAL
270741_ALDRICH
270741_SIAL
277649_ALDRICH
277649_SIAL
2858_SIGMA
29221_FLUKA
32205_RIEDEL
32205_SIAL
32221_RIEDEL
32221_SIAL
32294_RIEDEL
32294_SIAL
34870_SIAL
34963_RIEDEL
39278_FLUKA
40210_ALDRICH
40210_RIEDEL
41322_FLUKA
458600_ALDRICH
458600_SIAL
459828_ALDRICH
459828_SIAL
459836_ALDRICH
459836_SIAL
459844_SIAL
48075_SUPELCO
493511_SIAL
493538_ALDRICH
493538_SIAL
493546_ALDRICH
493546_SIAL
64-17-5
676829_SIAL
68475-56-9
71076-86-3
71329-38-9
8000-16-6
8024-45-1
AC1L19TW
AC1Q31MM
AHD 2000
AI3-01706
ALCOHOL 5% IN D5-W
Absolute Alcohol
Absolute Ethanol
Absolute alcohol
Absolute ethanol
Absolute ethyl alcohol
Aethanol
Aethanol [German]
Aethylalkohol
Alcare Hand Degermer
Alcohol
Alcohol (USP)
Alcohol (ethyl)
Alcohol Anhydrous
Alcohol [USP]
Alcohol anhydrous
Alcohol dehydrated
Alcohol denatured
Alcohol etílico
Alcohol, Absolute
Alcohol, Dehydrated
Alcohol, Diluted
Alcohol, Grain
Alcohol, anhydrous
Alcohol, dehydrated
Alcohol, denatured
Alcohol, diluted
Alcohol, ethyl
Alcohols
Alcohols, C1-3
Alcohols, C30
Alcohols, C6-9
Alcool Ethylique
Alcool Etilico
Alcool ethylique
Alcool etilico
Alcool éthylique
Algrain
Alkohol
Alkohol [German]
Alkoholu Etylowego
Alkoholu etylowego
Aminoethanol
Anhydrol
Anhydrol PM 4085
Anhydrous alcohol
Anhydrous ethanol
Beta-Aminoethanol
Beta-Aminoethyl Alcohol
Beta-Ethanolamine
Beta-Hydroxyethylamine
C00469
C2H5OH
C2H6O
CCRIS 945
CDA 19
CDA 19-200
CHEBI:16236
CHEMBL545
CID702
Caswell No. 426
Caswell No. 430
Colamine
Cologne Spirit
Cologne spirit
Cologne spirits
 
D000431
D00068
DB00898
Dehydrated Ethanol
Dehydrated alcohol
Dehydrated ethanol
Denatured Alcohol
Denatured Alcohol Cd-10
Denatured Alcohol Cd-5
Denatured Alcohol Cd-5a
Denatured Alcohol Sd-1
Denatured Alcohol Sd-13a
Denatured Alcohol Sd-17
Denatured Alcohol Sd-23a
Denatured Alcohol Sd-28
Denatured Alcohol Sd-30
Denatured Alcohol Sd-39b
Denatured Alcohol Sd-39c
Denatured Alcohol Sd-3a
Denatured Alcohol Sd-40m
Denatured Ethanol
Denatured alcohol
Denatured ethanol
Desinfektol EL
Diluted Alcohol
Distilled spirits
E2385_SIGMA
E7023_ALDRICH
E7023_SIAL
E7148_ALDRICH
E7148_SIAL
E7517_SIGMA
EINECS 200-578-6
EINECS 270-649-4
EOH
EOX
ETA
Envision Conditioner Pdd 9020
Esumiru WK 88
EtOH
Etanolo
Etanolo [Italian]
Ethanol (9CI)
Ethanol 200 Proof
Ethanol 200 proof
Ethanol Absolute
Ethanol Absolute Bp
Ethanol Anhydrous
Ethanol Extra Pure
Ethanol Vapor
Ethanol [JAN]
Ethanol solution
Ethanol, Silent Spirit
Ethanol, undenatured
Ethanolum anhydricum
Ethicap
Ethyl Alcohol
Ethyl Alcohol & Water, 10%
Ethyl Alcohol & Water, 20%
Ethyl Alcohol & Water, 30%
Ethyl Alcohol & Water, 40%
Ethyl Alcohol & Water, 5%
Ethyl Alcohol & Water, 50%
Ethyl Alcohol & Water, 60%
Ethyl Alcohol & Water, 70%
Ethyl Alcohol & Water, 80%
Ethyl Alcohol & Water, 95%
Ethyl Alcohol & Water, 96%
Ethyl Alcohol Anhydrous
Ethyl Alcohol, Anhydrous
Ethyl Alcohol, Denatured
Ethyl Hydrate
Ethyl Hydroxide
Ethyl alc
Ethyl alcohol
Ethyl alcohol anhydrous
Ethyl alcohol in alcoholic beverages
Ethyl alcohol usp
Ethyl hydrate
Ethyl hydroxide
Ethylalcohol
Ethylalcohol [Dutch]
Ethylol
Ethylolamine
Ethyloxy Group
Etylowy alkohol
FEMA No. 2419
FEMA Number 2419
Fermentation alcohol
Glycinol
Grain alcohol
HSDB 531
HSDB 82
HYDROXYETHYL GROUP
Hinetoless
Hydroxyethane
I14-12648
IMS 99
Infinity Pure
Jaysol
Jaysol S
LS-1539
LTBB002977
Lux
Methylated Spirit Mineralised
Methylated spirit
Methylcarbinol
MolPort-001-785-844
Molasses alcohol
NCGC00091458-01
NCI-C03134
NSC 85228
NSC85228
Oxydimethylene Group
Potato alcohol
Punctilious ethyl alcohol
Pyro
QMHAIh@
Reagent Alcohol
Ru-Tuss Expectorant
SDA 3A
SDA 40-2
SDM No. 37
SY Fresh M
Sekundasprit
Silent spirit
Spirit
Spirits of wine
Spiritus vini
Spirt
Synasol
Tecsol
Tecsol C
Thanol
Thiofaco M-50
UNII-3K9958V90M
USAF EK-1597
Undenatured Ethanol
WLN: Q2
absolute alcohol
alcohol
alcohol etilico
bmse000297
etanol
ethanol
ethyl alcohol
grain alcohol
nchem.651-comp3c
nchembio.552-comp10
nchembio.94-comp20
spiritus vini
Äthanol
Äthylalkohol
éthanol
38
Propranololapproved, investigational216525-66-64946
Synonyms:
(+-)-Propranolol
(1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol
(R)-(+)-propranolol
(S)-(-)-PROPRANOLOL
1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol
1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane
1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol
1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol
1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol
1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol
1-Isopropylamino-3-(1-naphthyloxy)-2-propanol
1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol
1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
13013-17-7
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI)
2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI)
3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol
4199-09-1
4199-10-4
525-66-6
AB00053537
AC1L1JA4
AC1Q1QBV
AC1Q1QC0
AKOS000588816
AY 64043
AY-20694
Anaprilin
Anapriline
Angilol
Apsolol
Avlocardyl
BPBio1_001040
BRD-A10070317-003-06-9
BSPBio_000944
BSPBio_002682
Bedranol
Beprane
Berkolol
Beta Neg
Beta-Neg
Beta-Propranolol
Beta-Tablinen
Beta-Timelets
Betachron
Betadren
Betalong
Bio-0732
Bio1_000367
Bio1_000856
Bio1_001345
C07407
C16H21NO2
CBDivE_006180
CCRIS 3082
CHEBI:8499
CHEMBL27
CID4946
Cardinol
Caridolol
Corpendol
D,L-Propranolol
D08443
DB00571
DL-Propranolol hydrochloride
Deralin
DivK1c_000023
Dl-Propranolol Hydrochloride
Dociton
Duranol
EINECS 208-378-0
EINECS 235-867-6
Efektolol
Elbrol
Etalong
Euprovasin
Frekven
HMS2090L21
Herzbase
ICI 45520
IDI1_000023
INDERIDE-40/25
INDERIDE-80/25
Ikopal
Inderal
Inderal La
Inderal hydrochloride
Inderalici
Inderex
Inderide
Inderol
Indobloc
InnoPranXL
 
Innopran XL
Intermigran
KBio1_000023
KBio2_002515
KBio2_005083
KBio2_007651
KBio3_001766
KBio3_001902
KBio3_002993
KBioGR_001347
KBioGR_001684
KBioGR_002515
KBioSS_002523
Kemi
Kemi S
L000679
LS-122410
LS-184129
Lopac0_000896
Migrastat
MolPort-001-794-623
NCGC00015798-07
NCGC00024690-02
NCGC00024690-03
NINDS_000023
NSC91523
Naprilin
Obsidan
Obzidan
Oposim
Oprea1_304193
PDSP1_000767
PDSP1_001607
PDSP1_001608
PDSP2_000755
PDSP2_001591
PDSP2_001592
Prano-Puren
Pranolol
Prestwick0_000952
Prestwick1_000952
Prestwick2_000952
Prestwick3_000952
Pronovan
Propanalol
Propanix
Propanolol
Propanolol [INN-Spanish]
Prophylux
Propranalol
Propranolol
Propranolol (INN)
Propranolol (TN)
Propranolol Hcl
Propranolol Hcl Intensol
Propranolol Hydrochloride
Propranolol [INN:BAN]
Propranololo
Propranololo [DCIT]
Propranololum
Propranololum [INN-Latin]
Propranur
Proprasylyt
Pylapron
R,S-Propranolol Hydrochloride
Racemic propranolol
Rapynogen
Reducor
Reducor Line
Reducor line
SPBio_001361
SPBio_001658
SPBio_003093
STK735510
Sagittol
Sawatal
Servanolol
Sloprolol
Spectrum2_001301
Spectrum2_001699
Spectrum3_000883
Spectrum3_001071
Spectrum4_000974
Spectrum4_001222
Spectrum5_000751
Sumial
Tesnol
UNII-9Y8NXQ24VQ
b-Propranolol
beta-Propranolol
cMAP_000071
etalong
propranolol
propranololo
β-Propranolol
39Vasodilator Agents3438
40Antihypertensive Agents4095
41Complement System Proteins228
42Adrenergic Antagonists1535
43Adrenergic Agents5140
44Adrenergic beta-Antagonists1154
45Anti-Arrhythmia Agents2969

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1A Multicenter Trial of the Efficacy and Safety of Diclegis® for Nausea and Vomiting of Pregnancy in Pregnant AdolescentsRecruitingNCT02045901Phase 4
2Efficacy/Safety Study of Brisdelle™ (Formerly Known as Mesafem) in the Treatment of Vasomotor Symptoms (VMS)CompletedNCT01361308Phase 3
3Outcomes After Perforator Flap Reconstruction for Breast Reconstruction and/or Lymphedema TreatmentUnknown statusNCT01273909
4Validation of a New Method of Limb VolumetryUnknown statusNCT01574911
5Physical Therapies in the Decongestive Treatment of LymphedemaCompletedNCT01748604
6Out-of Pocket Payments in Patients With LymphedemaRecruitingNCT02988479
7Out-of Pocket Payments With Lymphedema in FranceRecruitingNCT02988505
8Validation of Metrological Properties of LymphoqolRecruitingNCT01922635
9Engineering an Online STI Prevention ProgramRecruitingNCT02897804
10Quality of Life Changes on Lower Extremity Lymphedema Patients Using an Advanced PCDRecruitingNCT02661646
11Imaging Lymphatic Function in Normal Subjects and in Persons With Lymphatic DisordersEnrolling by invitationNCT00833599
12Propranolol Dose Escalation in Lymphedema in PatientsNot yet recruitingNCT02595996
13Oedema Study : ChroedemNot yet recruitingNCT02914808

Search NIH Clinical Center for Lymphedema, Hereditary, Ia

Genetic Tests for Lymphedema, Hereditary, Ia

About this section

Genetic tests related to Lymphedema, Hereditary, Ia:

id Genetic test Affiliating Genes
1 Hereditary Lymphedema Type I27
2 Milroy Disease24 FLT4

Anatomical Context for Lymphedema, Hereditary, Ia

About this section

MalaCards organs/tissues related to Lymphedema, Hereditary, Ia:

36
Skin, Testis, Breast, Lymph node

FMA organs/tissues related to Lymphedema, Hereditary, Ia:

17
Legs

Publications for Lymphedema, Hereditary, Ia

About this section

Variations for Lymphedema, Hereditary, Ia

About this section

UniProtKB/Swiss-Prot genetic disease variations for Lymphedema, Hereditary, Ia:

70 (show all 11)
id Symbol AA change Variation ID SNP ID
1FLT4p.Gly857ArgVAR_018409rs267606818
2FLT4p.His1035ArgVAR_018412rs121909653
3FLT4p.Arg1041ProVAR_018413rs121909650
4FLT4p.Leu1044ProVAR_018414rs121909651
5FLT4p.Pro1114LeuVAR_018415rs121909652
6FLT4p.Ala855ThrVAR_074044rs121909657
7FLT4p.Val878MetVAR_074045rs121909654
8FLT4p.Gln1020LeuVAR_074046
9FLT4p.Ile1086ThrVAR_074048rs121909655
10FLT4p.Glu1106LysVAR_074049rs121909656
11FLT4p.Ser1235CysVAR_074051

Clinvar genetic disease variations for Lymphedema, Hereditary, Ia:

5
id Gene Variation Type Significance SNP ID Assembly Location
1FLT4NM_182925.4(FLT4): c.2569G> A (p.Gly857Arg)SNVPathogenicrs267606818GRCh37Chr 5, 180046743: 180046743
2FLT4NM_182925.4(FLT4): c.3122G> C (p.Arg1041Pro)SNVPathogenicrs121909650GRCh37Chr 5, 180043464: 180043464
3FLT4NM_182925.4(FLT4): c.3131T> C (p.Leu1044Pro)SNVPathogenicrs121909651GRCh37Chr 5, 180043455: 180043455
4FLT4NM_182925.4(FLT4): c.3341C> T (p.Pro1114Leu)SNVPathogenicrs121909652GRCh37Chr 5, 180040101: 180040101
5FLT4NM_182925.4(FLT4): c.3104A> G (p.His1035Arg)SNVPathogenicrs121909653GRCh37Chr 5, 180043482: 180043482
6FLT4NM_182925.4(FLT4): c.2632G> A (p.Val878Met)SNVPathogenicrs121909654GRCh37Chr 5, 180046680: 180046680
7FLT4NM_182925.4(FLT4): c.3257T> C (p.Ile1086Thr)SNVPathogenicrs121909655GRCh37Chr 5, 180041142: 180041142
8FLT4NM_182925.4(FLT4): c.3316G> A (p.Glu1106Lys)SNVPathogenicrs121909656GRCh37Chr 5, 180041083: 180041083
9FLT4NM_182925.4(FLT4): c.3323_3325delTCT (p.Phe1108del)deletionPathogenicrs587776833GRCh38Chr 5, 180614074: 180614076
10FLT4NM_182925.4(FLT4): c.2563G> A (p.Ala855Thr)SNVPathogenicrs121909657GRCh37Chr 5, 180046749: 180046749

Expression for genes affiliated with Lymphedema, Hereditary, Ia

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Search GEO for disease gene expression data for Lymphedema, Hereditary, Ia.

Pathways for genes affiliated with Lymphedema, Hereditary, Ia

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Pathways related to Lymphedema, Hereditary, Ia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.4FLT4, VEGFC
29.4FLT4, VEGFC
3
Show member pathways
9.4FLT4, VEGFC
49.3FOXC2, VEGFC
5
Show member pathways
8.9FLT4, PROX1, VEGFC

GO Terms for genes affiliated with Lymphedema, Hereditary, Ia

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Biological processes related to Lymphedema, Hereditary, Ia according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of endothelial cell proliferationGO:000193810.2FLT4, PROX1
2kidney developmentGO:000182210.2FOXC2, PROX1
3blood vessel developmentGO:00015689.9FOXC2, SOX18
4embryonic heart tube developmentGO:00350509.9FOXC2, SOX18
5endocardium formationGO:00602149.9PROX1, SOX18
6lymphatic endothelial cell differentiationGO:00608369.8PROX1, SOX18
7positive regulation of endothelial cell migrationGO:00105959.7FLT4, FOXC2, PROX1
8vasculature developmentGO:00019449.6FLT4, SOX18
9positive regulation of cell proliferationGO:00082849.6FLT4, PROX1, VEGFC
10ventricular cardiac muscle tissue morphogenesisGO:00550109.4FOXC2, PROX1
11vascular endothelial growth factor receptor signaling pathwayGO:00480109.4FLT4, FOXC2, VEGFC
12positive regulation of transcription, DNA-templatedGO:00458939.2FOXC2, PROX1, SOX18
13lymph vessel developmentGO:00019458.9FLT4, FOXC2, PROX1, SOX18
14lymphangiogenesisGO:00019468.9FLT4, FOXC2, PROX1, SOX18

Molecular functions related to Lymphedema, Hereditary, Ia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:000370510.0FOXC2, PROX1
2sequence-specific DNA bindingGO:00435659.2FOXC2, PROX1, SOX18
3transcription regulatory region DNA bindingGO:00442128.6FOXC2, PROX1, SOX18

Sources for Lymphedema, Hereditary, Ia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet