MCID: LYM026
MIFTS: 49

Lymphoblastic Leukemia malady

Summaries for Lymphoblastic Leukemia

Sources:
33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Lymphoblastic Leukemia, also known as acute lymphocytic leukemia, is related to acute leukemia and acute lymphoblastic leukemia, childhood. An important gene associated with Lymphoblastic Leukemia is TSPAN7 (tetraspanin 7), and among its related pathways are Transcriptional misregulation in cancer and Lymphocyte Signaling. The compound af 10 have been mentioned in the context of this disorder. Related mouse phenotypes are hematopoietic system and cellular.

Aliases & Classifications for Lymphoblastic Leukemia

Sources:
61UMLS, 8Disease Ontology, 10DISEASES, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

lymphoblastic leukemia 8 10
acute lymphocytic leukemia 61


External Ids:

Disease Ontology8 DOID:1037
ICD9CM27 204.9, 204
MeSH35 D007945
NCIt40 C7539

Related Diseases for Lymphoblastic Leukemia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 354)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia32.5FLT3, PBX1, LMO2, LYL1
2acute lymphoblastic leukemia, childhood32.1IKZF1, FLT3, TLX1
3lymphoblastic lymphoma31.5LMO2, FLI1
4acute myeloid leukemia31.3PICALM, FLT3
5precursor t-cell acute lymphoblastic leukemia31.2LMO2, LYL1, FLT3, PICALM, TLX1, IKZF1
6acute lymphocytic leukemia31.0BLNK, LMO2, PBX1, IKZF1, FLT3, TCF3
7burkitt's lymphoma30.5TLX1, PICALM, FLT3, BLNK, IKZF1, PBX1
8t-cell leukemia11.3
9acute t cell leukemia11.3
10adult acute lymphocytic leukemia11.1
11lymphocytic leukemia, acute t-cell10.9
12adult t-cell leukemia10.7
13pre-b-cell acute lymphoblastic leukemia10.7
14leukemia, acute pre-b-cell10.7
15precursor b-cell acute lymphoblastic leukemia10.7
16leukemia/lymphoma, t-cell10.7
17leukemia, acute lymphoblastic 210.7
18central nervous system leukemia10.6
19glucocorticoid resistance10.6
20adult lymphoma10.6
21hematopoietic stem cell transplantation10.6
22pediatric t-cell leukemia10.6
23acute non lymphoblastic leukemia10.6
24bone marrow necrosis10.5
25chronic myeloid leukemia10.5
26hypercalcemia10.5
27wilms tumor10.5
28leukemia, acute lymphocytic 110.5
29n syndrome10.5
30acute myelomonocytic leukemia10.5
31hemophagocytic lymphohistiocytosis10.4
32familial acute lymphocytic leukemia10.4
33graft versus host disease10.4
34lymphoid leukemia10.4
35osteonecrosis10.4
36acute graft versus host disease10.4
37hypertriglyceridemia10.4
38fusariosis10.4
39testicular leukemia10.4
40hyperphosphatemia10.4
41pediatric lymphoma10.4
42acute pancreatitis10.3
43precursor b lymphoblastic lymphoma/leukemia10.3
44ataxia telangiectasia10.3
45noonan syndrome10.3
46arthritis10.3
47acute myeloid leukemia, adult10.3
48acute myeloid leukemia, childhood10.3
49chronic myelomonocytic leukemia10.3
50leukemia, t-cell, chronic10.3

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia:



Diseases related to lymphoblastic leukemia

Clinical Features for Lymphoblastic Leukemia

Drugs & Therapeutics for Lymphoblastic Leukemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Lymphoblastic Leukemia

Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Leukemia

Search NIH Clinical Center for Lymphoblastic Leukemia

Search CenterWatch for Lymphoblastic Leukemia

Genetic Tests for Lymphoblastic Leukemia

Anatomical Context for Lymphoblastic Leukemia

Animal Models for Lymphoblastic Leukemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lymphoblastic Leukemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.9TLX1, LYL1, TCF3, LMO2, PBX1, TAL2
2MP:000538412.8LYL1, LMO2, PBX1, ABCC5, OLIG2, IKZF1
3MP:001076812.7TCF3, LMO2, AFF4, OLIG2, PBX1, IKZF1
4MP:000537812.6FLT3, TPD52L2, ARID5B, PICALM, FLI1, AFF4
5MP:000538712.3FLT3, LMO2, LYL1, PBX1, IKZF1, BLNK
6MP:000200611.4FLI1, BLNK, IKZF1, OLIG2, TCF3, FLT3
7MP:000538011.2TCF3, TLX1, AFF4, LMO2

Publications for Lymphoblastic Leukemia

Sources:
51PubMed
See all sources

Articles related to Lymphoblastic Leukemia:

(show top 50)    (show all 2802)
idTitleAuthorsYear
1
Philadelphia chromosome negative very high risk acute lymphoblastic leukemia (ALL) in children and adolescents: results from children's oncology group (COG) study AALL0031. (24434862)
2014
2
CD22 monoclonal antibody therapies in relapsed/refractory acute lymphoblastic leukemia. (23633448)
2013
3
A mouse model for inducible overexpression of Prdm14 results in rapid-onset and highly penetrant T-cell acute lymphoblastic leukemia (T-ALL). (24046360)
2013
4
Gene-Environment Interactions and the Risk of Childhood Acute Lymphoblastic Leukemia: Exploring the Role of Maternal Folate Genes and Folic Acid Fortification. (24087922)
2013
5
CD44 and CD27 expression pattern in B cell precursor acute lymphoblastic leukemia and its clinical significance. (23263849)
2013
6
l-asparaginase: an effective agent in the treatment of acute lymphoblastic leukemia. (23662993)
2013
7
Genetic variations in MDM2 and P53 genes confer risk for adult acute lymphoblastic leukemia in a Chinese population. (23745682)
2013
8
Outcome of patients with acute lymphoblastic leukemia (ALL) following induction therapy with a modified (pulsed dexamethasone rather than continuous prednisone) UKALL XII/ECOG E2993 protocol at Tawam Hospital, United Arab Emirates (UAE). (23468219)
2013
9
Interleukin-2 priming chemotherapy: a strategy to improve the remission of refractory/relapsed T cell acute lymphoblastic leukemia. (24074835)
2013
10
Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies. (22943282)
2012
11
Cryptosporidium gastroenteritis in Egyptian children with acute lymphoblastic leukemia: magnitude of the problem. (22189516)
2012
12
The functional analysis of polymorphic insertions of Alu retroelements at acute lymphoblastic leukemia]. (22997707)
2012
13
Multidrug resistance-associated protein 1 predicts relapse in Iranian childhood acute lymphoblastic leukemia. (22901208)
2012
14
c-Myb interacts with the glucocorticoid receptor and regulates its level in pre-B-acute lymphoblastic leukemia cells. (22516378)
2012
15
Expression of Ikaros isoform 6 in chinese children with acute lymphoblastic leukemia. (21792038)
2011
16
Chronic recurrent multifocal osteomyelitis as the first presentation of acute lymphoblastic leukemia in a 2-year-old boy. (20445409)
2010
17
beta-catenin is involved in N-cadherin-dependent adhesion, but not in canonical Wnt signaling in E2A-PBX1-positive B acute lymphoblastic leukemia cells. (19101069)
2009
18
Inhibition of glycolysis modulates prednisolone resistance in acute lymphoblastic leukemia cells. (18978206)
2009
19
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. (18663146)
2008
20
Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines. (17560996)
2007
21
Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia. (18158072)
2007
22
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (16847353)
2006
23
Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemia. (16894525)
2006
24
Near-triploidy and near-tetraploidy in childhood acute lymphoblastic leukemia: association with B-lineage blast cells carrying the ETV6-RUNX1 fusion, T-lineage immunophenotype, and favorable outcome. (16875937)
2006
25
Acquired Glanzmann's thrombasthenia associated with acute lymphoblastic leukemia. (16217260)
2005
26
Genetic variations in the glucocorticoid receptor gene are not related to glucocorticoid resistance in childhood acute lymphoblastic leukemia. (16115950)
2005
27
Study on the correlation between acute lymphoblastic leukemia and HLA genes in southern China Han population]. (15854278)
2005
28
GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia. (15717687)
2005
29
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression. (15374878)
2005
30
Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia. (14647408)
2004
31
TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia. (15328172)
2004
32
A case of infantile acute lymphoblastic leukemia presenting with rearrangement of MLL at 11q23 and apparent insertion or translocation at 10p12. (15381373)
2004
33
Transformation of myelodysplastic syndrome to acute lymphoblastic leukemia: a case report and review of the literature. (15005342)
2004
34
Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. (12958073)
2004
35
Suppression of adrenal function in children with acute lymphoblastic leukemia following induction therapy with corticosteroid and other cytotoxic agents. (15192618)
2004
36
HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. (12851685)
2003
37
Methylation of CpG dinucleotides and/or CCWGG motifs at the promoter of TP53 correlates with decreased gene expression in a subset of acute lymphoblastic leukemia patients. (12592393)
2003
38
Degradation of vincristine by myeloperoxidase and hypochlorous acid in children with acute lymphoblastic leukemia. (12921949)
2003
39
Growth of human T cell acute lymphoblastic leukemia lymphoblasts in NOD/SCID mouse fetal thymus organ culture. (12145696)
2002
40
Energy expenditure, energy intake and prevalence of obesity after therapy for acute lymphoblastic leukemia during childhood. (11044803)
2000
41
Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy. (8874207)
1996
42
Demodicidosis in childhood acute lymphoblastic leukemia; an opportunistic infection occurring with immunosuppression. (7472831)
1995
43
The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. (7780150)
1995
44
SIL/TAL1 recombination in adult T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma. (8548743)
1995
45
Establishment of a new human pre-B acute lymphoblastic leukemia cell line (KMO-90) with 1;19 translocation carrying p53 gene alterations. (8412323)
1993
46
Fetal hemoglobin and the gamma G/gamma A chain ratio in children with acute lymphoblastic leukemia L1 and L2]. (7682338)
1993
47
Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia. (1516826)
1992
48
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia. (1737852)
1992
49
Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. (6375764)
1984
50
An intensive care chemo- or chemoimmunotherapy regimen for patients with intermediate and poor-prognosis acute lymphatic leukemia and leukemic lymphoblastic lymphosarcoma: preliminary results with 14-month median follow-up. (6949235)
1982

Genetic Variations for Lymphoblastic Leukemia

Expression for genes affiliated with Lymphoblastic Leukemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphoblastic Leukemia

Search GEO for disease gene expression data for Lymphoblastic Leukemia.

Pathways for genes affiliated with Lymphoblastic Leukemia

Sources:
30KEGG, 4Cell Signaling Technology, 54Reactome
See all sources

Pathways related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9LYL1, TLX1, FLT3, FLI1, PBX1, LMO2
211.3FLI1, BLNK, IKZF1, PBX1, TCF3
3
Hide members
10.8TCF3, MEF2D

Compounds for genes affiliated with Lymphoblastic Leukemia

Sources:
45Novoseek
See all sources

Compounds related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1af 104510.8PICALM, TLX1

GO Terms for genes affiliated with Lymphoblastic Leukemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.7LYL1, ARID5B, PICALM, MEF2D, FLI1, AFF4

Biological processes related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594411.7TLX1, MEF2D, IKZF1, LMO2, TCF3, BCL9
2B cell differentiationGO:03018311.5LYL1, TCF3, IKZF1, BLNK, FLT3
3Peyers patch developmentGO:04854111.0IKZF1, TCF3
4thalamus developmentGO:02179410.9OLIG2, TAL2
5cell developmentGO:04846810.9ARID5B, TCF3
6natural killer cell differentiationGO:00177910.8IKZF1, TCF3
7spleen developmentGO:04853610.8PBX1, TLX1
8embryonic hemopoiesisGO:03516210.7LMO2, PBX1
9adrenal gland developmentGO:03032510.5PBX1, ARID5B

Molecular functions related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.8FLT3, MEF2D, PICALM, ARID5B, TLX1, AFF4
2DNA bindingGO:00367712.0ARID5B, FLI1, IKZF1, TAL2, OLIG2, PBX1
3sequence-specific DNA binding transcription factor activityGO:00370011.9TCF3, TLX1, MEF2D, FLI1, AFF4, IKZF1
4protein heterodimerization activityGO:04698211.2TLX1, IKZF1, PBX1, TCF3
5protein dimerization activityGO:04698310.9LYL1, TAL2, MEF2D
6bHLH transcription factor bindingGO:04342510.9TCF3, LMO2
7E-box bindingGO:07088810.8TCF3, LMO2
8RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.5LMO2, MEF2D

Products for genes affiliated with Lymphoblastic Leukemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphoblastic Leukemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet