MCID: LYM026
MIFTS: 60

Lymphoblastic Leukemia

Categories: Cancer diseases, Immune diseases, Genetic diseases, Rare diseases, Blood diseases

Aliases & Classifications for Lymphoblastic Leukemia

MalaCards integrated aliases for Lymphoblastic Leukemia:

Name: Lymphoblastic Leukemia 12 14
Precursor Cell Lymphoblastic Leukemia Lymphoma 69
Acute Lymphocytic Leukemia 69
Leukemia, Lymphoid 42
Lymphoid Leukemia 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1037
ICD10 33 C91 C91.9 C91.90
ICD9CM 35 204 204.9
MeSH 42 D007945
NCIt 47 C7539
UMLS 69 C0023448

Summaries for Lymphoblastic Leukemia

Disease Ontology : 12 A leukemia that has material basis in lymphoblasts (immature white blood cells).

MalaCards based summary : Lymphoblastic Leukemia, also known as precursor cell lymphoblastic leukemia lymphoma, is related to acute lymphoblastic leukemia, childhood and acute pre-b-cell lymphoblastic leukemia, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Lymphoblastic Leukemia is FLT3 (Fms Related Tyrosine Kinase 3), and among its related pathways/superpathways are NF-kappaB Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Arranon and Blincyto have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are cellular and hematopoietic system

Related Diseases for Lymphoblastic Leukemia

Diseases in the Lymphoblastic Leukemia family:

Leukemia, Acute Lymphoblastic 2 Leukemia, Acute Lymphoblastic
Leukemia, Acute Lymphoblastic 3

Diseases related to Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 383)
id Related Disease Score Top Affiliating Genes
1 acute lymphoblastic leukemia, childhood 34.2 AFF1 ETV6 FLT3 RUNX1 TAL1 TCF3
2 acute pre-b-cell lymphoblastic leukemia 34.0 ETV6 FLT3
3 acute monocytic leukemia 30.8 ETV6 FLT3 RUNX1
4 hemolytic anemia 30.4 ABL1 ETV6 FLT3 IKZF1 NOTCH1 RUNX1
5 b-cell childhood acute lymphoblastic leukemia 12.2
6 leukemia, acute lymphoblastic 12.1
7 precursor t-cell acute lymphoblastic leukemia 12.1
8 acute non lymphoblastic leukemia 12.0
9 acute lymphoblastic leukemia congenital sporadic aniridia 11.9
10 acute lymphocytic leukemia 11.6
11 precursor lymphoblastic lymphoma/leukemia 11.5
12 leukemia 11.3
13 bone marrow necrosis 11.3
14 chronic lymphocytic leukemia 11.3
15 leukemia, acute myeloid 11.2
16 acute t cell leukemia 11.1
17 leukemia, acute lymphoblastic 3 11.1
18 b-cell adult acute lymphocytic leukemia 11.1
19 medulloblastoma 10.9
20 lymphoid leukemia 10.9
21 t-cell childhood acute lymphocytic leukemia 10.9
22 pulmonary valve agenesis-tetralogy of fallot-absence of ductus arteriosus syndrome 10.9 FLT3 RUNX1
23 t-cell adult acute lymphocytic leukemia 10.9
24 null-cell leukemia 10.9
25 acute necrotizing encephalopathy 10.9 ETV6 FLT3 RUNX1
26 deafness, autosomal recessive 8/10 10.8 ETV6 RUNX1
27 adult acute monocytic leukemia 10.8 IKZF1 RUNX1
28 chronic venous leg ulcers 10.8 ETV6 FLT3 RUNX1
29 nelson syndrome 10.7 ABL1 ETV6 FLT3 RUNX1
30 ankyloglossia 10.7 IKZF1 PBX1
31 peroxisome biogenesis disorder 7a 10.7 ABL1 ETV6 FLT3 RUNX1
32 molybdenum cofactor deficiency 10.7 ETV6 FLT3
33 breast osteosarcoma 10.6 ABL1 ETV6 PBX1 RUNX1 TCF3
34 idiopathic syringomyelia 10.6 ABL1 FLT3 NOTCH1 TAL1 TLX1
35 lymphoma 10.6
36 cranioectodermal dysplasia 1 10.6 ABL1 AFF1 ETV6 FLT3 RUNX1
37 cheek mucosa cancer 10.5 ABL1 ETV6 FLT3 RUNX1
38 acute myocardial infarction 10.5 ETV6 NBN NOTCH1 RUNX1 TAL1 TAL2
39 subacute thyroiditis 10.5 LMO2 TAL1 TLX1
40 lymphoblastic lymphoma 10.4
41 lymphoma, small cleaved-cell, diffuse 10.4 ETV6 RUNX1
42 preeclampsia/eclampsia 3 10.3 ABL1 AFF1 ETV6 FLT3 IKZF1 PBX1
43 myeloid leukemia 10.3
44 glucocorticoid resistance 10.3
45 childhood leukemia 10.2
46 hematopoietic stem cell transplantation 10.2
47 acute leukemia 10.2
48 prostate cancer 10.2
49 sarcoma 10.1
50 down syndrome 10.1

Comorbidity relations with Lymphoblastic Leukemia via Phenotypic Disease Network (PDN):


Deficiency Anemia Leukemia, B-Cell, Chronic
Neutropenia

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia:



Diseases related to Lymphoblastic Leukemia

Symptoms & Phenotypes for Lymphoblastic Leukemia

UMLS symptoms related to Lymphoblastic Leukemia:


angina pectoris, chest pain, edema

MGI Mouse Phenotypes related to Lymphoblastic Leukemia:

44 (show all 14)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 ABL1 AFF4 BAX ETV6 FLT3 IKZF1
2 hematopoietic system MP:0005397 10.41 ABL1 AFF1 AFF4 BAX ETV6 FLT3
3 growth/size/body region MP:0005378 10.4 ETV6 FLT3 IKZF1 LMO2 NBN NOTCH1
4 immune system MP:0005387 10.33 ABL1 AFF1 BAX ETV6 FLT3 IKZF1
5 endocrine/exocrine gland MP:0005379 10.29 ABL1 AFF1 AFF4 BAX ETV6 FLT3
6 mortality/aging MP:0010768 10.27 AFF4 BAX ETV6 FLT3 IKZF1 LMO2
7 embryo MP:0005380 10.26 ETV6 LMO2 NBN NOTCH1 PBX1 RUNX1
8 nervous system MP:0003631 10.07 ABL1 AFF1 BAX LMO2 NBN NOTCH1
9 integument MP:0010771 10.03 ETV6 IKZF1 LMO2 NOTCH1 PBX1 RUNX1
10 neoplasm MP:0002006 10.02 RUNX1 TCF3 FLT3 IKZF1 LMO2 NBN
11 liver/biliary system MP:0005370 9.95 ABL1 IKZF1 LMO2 NOTCH1 PBX1 RUNX1
12 no phenotypic analysis MP:0003012 9.7 IKZF1 OLIG2 RUNX1 TCF3 AFF1 ETV6
13 respiratory system MP:0005388 9.56 PBX1 RUNX1 ABL1 AFF4 BAX IKZF1
14 skeleton MP:0005390 9.28 ABL1 BAX FLT3 LMO2 NOTCH1 OLIG2

Drugs & Therapeutics for Lymphoblastic Leukemia

FDA approved drugs:

(show all 7)
id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Arranon 17 46 NELARABINE GlaxoSmithKline October 2005
2
Blincyto 17 46 BLINATUMOMAB Amgen December 2014
3
Clolar 17 46 CLOFARABINE Genzyme December, 2004
4
Erwinaze 17 46 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
5
Iclusig 17 46 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
6
Marqibo 17 46 VINCRISTINE SULFATE Talon Therapeutics August 2012
7
Sprycel 17 46 DASATINIB Bristol-Myers Squibb June 2006

Drugs for Lymphoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 688)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
2
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
3
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
4
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
5
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
6
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
7
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
8
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2068-78-2, 57-22-7 5978
9
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
10
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
11
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
12
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
13
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
14
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
15
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 4291-63-8 20279
16
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
17
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
18
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
19
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
20
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
21
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
22
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53910-25-1 40926 439693
23
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
24
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
25
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
26
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
27
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
28
Vidarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 24356-66-9 32326 21704
29 Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
30
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
31
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
32
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
33
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
34
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
35
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
36
Oprelvekin Approved, Investigational Phase 4 145941-26-0
37
Menthol Approved Phase 4 2216-51-5 16666
38
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 3081921 477468
39
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
40
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 14956 5280965
41
Nicotine Approved Phase 4 54-11-5 942 89594
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
43
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
44
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 67-97-0 6221 10883523 5280795
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 1406-16-2
46
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 50-14-6 5280793
47
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
48
Butyric Acid Experimental Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
49
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
50 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 2611)

id Name Status NCT ID Phase Drugs
1 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
2 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
3 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
4 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
5 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
6 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
7 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
8 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
9 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
10 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
11 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
12 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
13 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
14 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
15 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
16 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
17 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
18 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]
19 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
20 Observational Study in Participants With Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM) and Non-Hodgkin's Lymphoma (NHL) in Latin America Completed NCT02559583 Phase 4
21 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
22 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
23 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4 Valganciclovir
24 A Study of Rituximab in Combination With Fludarabine and Cyclophosphamide in Participants With Chronic Lymphocytic Leukemia and Favorable Somatic Status Completed NCT01271010 Phase 4 Cyclophosphamide;Fludarabine;Rituximab
25 A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status Completed NCT01283386 Phase 4 chlorambucil;cyclophosphamide;fludarabine;rituximab [MabThera]
26 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
27 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
28 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
29 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4 Ofatumumab
30 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
31 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
32 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
33 Effect of Epoetin Alfa on Hemoglobin, Symptom Distress, and Quality of Life in Patients Receiving Chemotherapy Completed NCT00524407 Phase 4 Epoetin alfa
34 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
35 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
36 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
37 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
38 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
39 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
40 Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS Recruiting NCT01540812 Phase 4 Vincristine in induction;Daunorubicin in induction;Prednisone in induction;Metotrexato in induction;Cytarabine in induction;Hydrocortisone in induction;Idarubicin in induction-2;Fludarabine in induction-2;Ara-C in induction-2;G-CSF in induction-2;Dexamethasone in consolidation-1;Vincristrine in consolidation-1;Metotrexato in consolidation-1;PEG-ASP in consolidation-1;Dexamethasone in consolidation-2;ARA-C in consolidation-2;PEG-ASP in consolidation-2;Dexamethasone in consolidation-3;Vincristine in consolidation-3;Metotrexato in consolidation-3;PEG-ASP in consolidation-3
41 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
42 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
43 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
44 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
45 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
46 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
47 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
48 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
49 Low Grade Lymphoma Recruiting NCT01698866 Phase 4
50 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate

Search NIH Clinical Center for Lymphoblastic Leukemia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: leukemia, lymphoid

Genetic Tests for Lymphoblastic Leukemia

Anatomical Context for Lymphoblastic Leukemia

MalaCards organs/tissues related to Lymphoblastic Leukemia:

39
B Cells, T Cells, Bone, Bone Marrow, Myeloid, Kidney, Nk Cells

Publications for Lymphoblastic Leukemia

Articles related to Lymphoblastic Leukemia:

(show top 50) (show all 3393)
id Title Authors Year
1
Successful second allogeneic stem cell transplantation in a patient with T-lymphoblastic leukemia (T-ALL) relapsed as myeloid sarcoma. ( 28451803 )
2017
2
Tyrosine Kinase Inhibitor for Treatment of Adult Allogeneic Hematopoietic Stem Cell Transplantation Candidate with Philadelphia-Positive Acute Lymphoblastic Leukemia. ( 28091401 )
2017
3
Salvage therapy for children with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia. ( 28084041 )
2017
4
Morphoproteomics Identifies SIRT1 and EZH2 Pathways as Commonalities in B-cell Acute Lymphoblastic Leukemia: Pathogenetic Implications and Opportunities for Therapeutic Intervention. ( 28249909 )
2017
5
Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia. ( 28923207 )
2017
6
Network-based expression analysis reveals key genes related to glucocorticoid resistance in infant acute lymphoblastic leukemia. ( 27798768 )
2017
7
Translocation t(8;14)(q24;q11) with concurrent PTEN alterations and deletions of STIL/TAL1 and CDKN2A/B in a pediatric case of acute T-lymphoblastic leukemia: A genetic profile associated with adverse prognosis. ( 27759908 )
2017
8
The dual specificity PI3K/mTOR inhibitor PKI-587 displays efficacy against T-cell acute lymphoblastic leukemia (T-ALL). ( 28159681 )
2017
9
JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. ( 28484265 )
2017
10
Overexpression of PTP4A3 in ETV6-RUNX1 acute lymphoblastic leukemia. ( 28063378 )
2017
11
Utility of the serum galactomannan assay for the diagnosis of invasive aspergillosis in children with acute lymphoblastic leukemia. ( 27815226 )
2017
12
Cellular kinetics of CTL019 in relapsed/refractory B-cell acute lymphoblastic leukemia and chronic lymphocytic leukemia. ( 28935694 )
2017
13
NHE1 has a notable role in metastasis and drug resistance of T-cell acute lymphoblastic leukemia. ( 28943936 )
2017
14
Systemic Juvenile Xanthogranuloma Involving the Bone Marrow, Multiple Bones, and the Skin That Developed During Treatment of Acute Lymphoblastic Leukemia in Remission State. ( 28836893 )
2017
15
Rates and Trends of Pediatric Acute Lymphoblastic Leukemia - United States, 2001-2014. ( 28910269 )
2017
16
KMT2E-ASNS: a novel relapse-specific fusion gene in early T-cell precursor acute lymphoblastic leukemia. ( 28069604 )
2017
17
Oncogenic ZEB2 activation drives sensitivity towards KDM1A inhibition in T-cell acute lymphoblastic leukemia. ( 28069602 )
2017
18
Blinatumomab activity in a patient with Down syndrome B-precursor acute lymphoblastic leukemia. ( 28921818 )
2017
19
Biomarker analysis and clinical relevance of TK1 on the cell membrane of Burkitt's lymphoma and acute lymphoblastic leukemia. ( 28919785 )
2017
20
Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia. ( 28033648 )
2017
21
Reversible Cerebral Vasoconstriction Syndrome during Chemotherapy for Acute Lymphoblastic Leukemia. ( 27769550 )
2017
22
Concordance of two approaches in monitoring of minimal residual disease in B-precursor acute lymphoblastic leukemia: Fusion transcripts and leukemia-associated immunophenotypes. ( 28063722 )
2017
23
Sinusoidal Obstruction Syndrome During Maintenance Therapy for Acute Lymphoblastic Leukemia With 6-Mercaptopurine and Methotrexate: A Pediatric Case Report. ( 28085749 )
2017
24
ABCC4 functional SNP in the 3' splice acceptor site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute lymphoblastic leukemia. ( 28550450 )
2017
25
Severe Mucha-Habermann-Like Ulceronecrotic Skin Disease in T-Cell Acute Lymphoblastic Leukemia Responsive to Basiliximab and Stem Cell Transplant. ( 28884915 )
2017
26
Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor. ( 28550041 )
2017
27
High expression of miR-125b-2 and SNORD116 noncoding RNA clusters characterize ERG-related B cell precursor acute lymphoblastic leukemia. ( 28415578 )
2017
28
Effect of Vitamin D Supplementation on Delayed Hyperphosphatemia in Pediatric Acute Lymphoblastic Leukemia Patients During Induction Chemotherapy. ( 28469534 )
2017
29
Ph-like acute lymphoblastic leukemia with a novel PAX5-KIDINS220 fusion transcript. ( 27870151 )
2017
30
Mixed Malarial Infection with Pancytopenia in a Child with Acute Lymphoblastic Leukemia: An Unusual Presentation. ( 28469349 )
2017
31
The Behavior Rating Inventory of Executive Function (BRIEF) to Identify Pediatric Acute Lymphoblastic Leukemia (ALL) Survivors At Risk for Neurocognitive Impairment. ( 28085741 )
2017
32
Interleukin-23 Receptor Gene Variants in Acute Lymphoblastic Leukemia and Their Relation to Prognostic Factors. ( 28341819 )
2017
33
Pancytopenia and Hypothyroidism in a Patient With Leukemic Infiltration of the Thyroid as the First Presentation of Acute Lymphoblastic Leukemia. ( 28562510 )
2017
34
TGFI^1 synergizes with FLT3 ligand to induce chemoresistant quiescence in acute lymphoblastic leukemia with MLL gene rearrangements. ( 28917156 )
2017
35
Lineage switch from B acute lymphoblastic leukemia to acute monocytic leukemia with persistent t(4;11)(q21;q23) and cytogenetic evolution under CD19-targeted therapy. ( 28634616 )
2017
36
Near-triploid B lymphoblastic leukemia with Burkitt-like morphology. ( 28082295 )
2017
37
Survival Outcome of Filipino Children With Acute Lymphoblastic Leukemia Treated With Modified Berlin-Frankfurt-Muenster/Hong Kong Acute Lymphoblastic Leukemia (BFM95/HKALL97) Protocol in a Tertiary General Hospital From January 2005 to December 2009: A Retrospective Cohort Study. ( 28085747 )
2017
38
New diagnosis of atypical ataxia-telangiectasia in a 17-year-old boy with T-cell acute lymphoblastic leukemia and a novel ATM mutation. ( 28123174 )
2017
39
IKZF1 gene in childhood B cell precursor acute lymphoblastic leukemia: interplay between genetic susceptibility and somatic abnormalities. ( 28947432 )
2017
40
Nosocomial legionellosis and invasive aspergillosis in a child with T-lymphoblastic leukemia. ( 28529020 )
2017
41
The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system. ( 27686375 )
2017
42
Extramedullary Gastric Relapse at the Time of Bone Marrow Relapse of Acute Lymphoblastic Leukemia after Allogeneic Bone Marrow Transplantation. ( 28943549 )
2017
43
Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia. ( 27637012 )
2017
44
ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype. ( 27634205 )
2017
45
Long-term Results of the Risk-adapted Treatment for Childhood B-Cell Acute Lymphoblastic Leukemia: Report From the Japan Association of Childhood Leukemia Study ALL-97 Trial. ( 28169879 )
2017
46
Clinical significance of the ABCB1 and ABCG2 gene expression levels in acute lymphoblastic leukemia. ( 27960630 )
2017
47
Acute lymphoblastic leukemia during the third trimester of pregnancy. ( 28914556 )
2017
48
BCR-ABL translocation as a favorable prognostic factor in elderly acute lymphoblastic leukemia patients in potent tyrosine kinase era. ( 28082339 )
2017
49
CREB knockdown inhibits growth and induces apoptosis in human pre-B acute lymphoblastic leukemia cells through inhibition of prosurvival signals. ( 28063408 )
2017
50
Genome-wide study links PNPLA3 variant with elevated hepatic transaminase after acute lymphoblastic leukemia therapy. ( 28090653 )
2017

Variations for Lymphoblastic Leukemia

Expression for Lymphoblastic Leukemia

Search GEO for disease gene expression data for Lymphoblastic Leukemia.

Pathways for Lymphoblastic Leukemia

GO Terms for Lymphoblastic Leukemia

Cellular components related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.61 ABL1 AFF4 BCL9 IKZF1 NBN NOTCH1
2 nucleus GO:0005634 9.6 ABL1 AFF1 AFF4 BAX BCL9 ETV6
3 transcription factor complex GO:0005667 9.46 LMO2 PBX1 TAL1 TCF3

Biological processes related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 9.99 AFF4 ETV6 PBX1 RUNX1 TLX1
2 multicellular organism development GO:0007275 9.98 IKZF1 LMO2 NOTCH1 OLIG2 PBX1 TAL1
3 transcription, DNA-templated GO:0006351 9.9 AFF4 ETV6 IKZF1 LYL1 NOTCH1 OLIG2
4 regulation of cell proliferation GO:0042127 9.8 ABL1 NOTCH1 PBX1 TAL1
5 post-embryonic development GO:0009791 9.71 ABL1 BAX TAL2
6 hemopoiesis GO:0030097 9.69 FLT3 RUNX1 TAL1
7 B cell differentiation GO:0030183 9.65 FLT3 LYL1 TCF3
8 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.65 BCL9 ETV6 IKZF1 LMO2 NOTCH1 PBX1
9 neuron differentiation GO:0030182 9.62 ABL1 NOTCH1 OLIG2 TAL1
10 definitive hemopoiesis GO:0060216 9.58 LYL1 TAL1
11 embryonic hemopoiesis GO:0035162 9.58 PBX1 TAL1
12 negative regulation of neuron differentiation GO:0045665 9.58 NOTCH1 OLIG2 PBX1
13 hematopoietic stem cell proliferation GO:0071425 9.56 ETV6 RUNX1
14 thalamus development GO:0021794 9.55 OLIG2 TAL2
15 regulation of transcription, DNA-templated GO:0006355 9.47 ABL1 AFF1 AFF4 ETV6 IKZF1 LYL1
16 leukocyte homeostasis GO:0001776 9.37 BAX FLT3
17 apoptotic process involved in embryonic digit morphogenesis GO:1902263 9.26 BAX NOTCH1
18 regulation of myeloid cell differentiation GO:0045637 9.22 TAL1
19 positive regulation of interferon-gamma secretion GO:1902715 9.16 ABL1
20 cell differentiation GO:0030154 10.04 ETV6 FLT3 NOTCH1 PBX1 TAL1 TCF3
21 positive regulation of transcription, DNA-templated GO:0045893 10 LYL1 NOTCH1 RUNX1 TAL1 TCF3

Molecular functions related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.9 ABL1 ETV6 IKZF1 LYL1 OLIG2 PBX1
2 protein heterodimerization activity GO:0046982 9.83 BAX NOTCH1 PBX1 TAL1 TCF3
3 protein dimerization activity GO:0046983 9.72 LYL1 OLIG2 TAL1 TAL2 TCF3
4 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.65 ETV6 LMO2 LYL1 TAL1 TAL2
5 transcription factor activity, sequence-specific DNA binding GO:0003700 9.65 AFF1 AFF4 ETV6 IKZF1 NOTCH1 OLIG2
6 E-box binding GO:0070888 9.58 LMO2 TAL1 TCF3
7 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.46 LMO2 NOTCH1
8 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.1 ETV6 LMO2 LYL1 RUNX1 TAL1 TAL2
9 protein binding GO:0005515 10.32 ABL1 AFF1 AFF4 BAX BCL9 ETV6

Sources for Lymphoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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