MCID: LYM026
MIFTS: 54

Lymphoblastic Leukemia malady

Cancer diseases, Immune diseases, Blood diseases, Rare diseases categories

Summaries for Lymphoblastic Leukemia

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34MalaCards
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MalaCards: Lymphoblastic Leukemia, also known as acute lymphocytic leukemia, is related to leukemia and lymphoblastic lymphoma. An important gene associated with Lymphoblastic Leukemia is TSPAN7 (tetraspanin 7), and among its related pathways are CDO in myogenesis and Lymphocyte Signaling. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Lymphoblastic Leukemia

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9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Immune diseases, Blood diseases


Aliases & Descriptions:

lymphoblastic leukemia 9 11
acute lymphocytic leukemia 63


External Ids:

Disease Ontology9 DOID:1037
ICD9CM28 204.9, 204
MeSH36 D007945
NCIt41 C7539

Related Diseases for Lymphoblastic Leukemia

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18GeneCards, 19GeneDecks
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Diseases in the Leukemia, Acute Lymphoblastic 3 family:

lymphoblastic leukemia Leukemia, Acute Lymphoblastic 2

Diseases related to Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 365)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5OLIG2, ABCC5, PICALM, MLLT4, BLNK, LMO2
2lymphoblastic lymphoma31.3FLI1, LMO2
3acute leukemia31.0MLLT4, LMO2, FLT3, PBX1, LYL1
4acute lymphocytic leukemia30.9ABCC5, PICALM, BLNK, LMO2, FLT3, TCF3
5precursor t-cell acute lymphoblastic leukemia30.7IKZF1, LYL1, FLT3, LMO2, PICALM
6non-hodgkin lymphoma30.6IKZF1, FLT3, FLI1
7breast cancer30.6ABCC5, TPD52L2, LMO2, FLI1, FLT3, PBX1
8burkitt's lymphoma30.4PICALM, BLNK, LMO2, FLI1, FLT3, PBX1
9leukemia, acute lymphoblastic 330.4PBX1, FLT3
10acute non lymphoblastic leukemia10.9
11pre-b-cell acute lymphoblastic leukemia10.8
12myeloid leukemia10.7
13hematopoietic stem cell transplantation10.7
14childhood leukemia10.6
15glucocorticoid resistance10.6
16acute myeloid leukemia10.6
17hypercalcemia10.5
18bone marrow necrosis10.5
19down syndrome10.5
20wilms tumor10.5
21myelodysplastic syndromes10.5
22endotheliitis10.5
23chronic myeloid leukemia10.5
24hemophagocytic lymphohistiocytosis10.5
25acute t cell leukemia10.5
26acute lymphoblastic leukemia, childhood10.5
27graft versus host disease10.4
28osteonecrosis10.4
29eosinophilia10.4
30neutropenia10.4
31sarcoma10.4
32hypertriglyceridemia10.4
33fusariosis10.4
34cerebritis10.4
35hyperphosphatemia10.4
36hepatitis10.4
37hodgkin's lymphoma10.4
38obesity10.4
39pancreatitis10.4
40retinitis10.4
41ataxia telangiectasia10.4
42noonan syndrome10.4
43arthritis10.4
44chronic lymphocytic leukemia10.4
45influenza10.4
46neuropathy10.4
47ataxia10.4
48bacteremia10.4
49neurofibromatosis10.3
50hypoglycemia10.3

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia:



Diseases related to lymphoblastic leukemia

Symptoms for Lymphoblastic Leukemia

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Drugs & Therapeutics for Lymphoblastic Leukemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Lymphoblastic Leukemia

Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Leukemia

Search NIH Clinical Center for Lymphoblastic Leukemia

Search CenterWatch for Lymphoblastic Leukemia

Genetic Tests for Lymphoblastic Leukemia

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Anatomical Context for Lymphoblastic Leukemia

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34MalaCards
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MalaCards organs/tissues related to Lymphoblastic Leukemia:

34
T cells, B cells, Bone, Bone marrow, Myeloid, B lymphoblasts, Endothelial, Lung, Breast, Brain, Monocytes, Liver, Thymus, Thyroid, Spleen, Whole blood, Testes, Kidney, Tongue, Pineal, Temporal lobe, Tonsil, Testis, Prostate, Placenta, Uterus, Skin, Colon, Spinal cord, Pituitary

Animal Models for Lymphoblastic Leukemia or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lymphoblastic Leukemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.6IKZF1, PBX1, FLI1, LMO2, PICALM
2MP:00020069.3TCF3, OLIG2, IKZF1, FLT3, FLI1, LMO2
3MP:00053808.9MLLT4, TCF3, FLI1, PBX1, LMO2, AFF4
4MP:00053878.8ARID5B, IKZF1, LYL1, PBX1, TCF3, FLT3
5MP:00053848.7ARID5B, PBX1, TCF3, FLT3, FLI1, LMO2
6MP:00053978.5TAL2, PICALM, BLNK, AFF4, LMO2, FLI1
7MP:00053788.3TAL2, MLLT4, AFF4, TPD52L2, LMO2, FLI1
8MP:00107688.1PICALM, MLLT4, TAL2, OLIG2, MEF2D, IKZF1

Publications for Lymphoblastic Leukemia

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53PubMed
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Articles related to Lymphoblastic Leukemia:

(show top 50)    (show all 2703)
idTitleAuthorsYear
1
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
2
Prognostic value of plasma levels of thrombomodulin and von Willebrand factor in Egyptian children with acute lymphoblastic leukemia. (24243921)
2013
3
Using a bayesian hierarchical model for identifying single nucleotide polymorphisms associated with childhood acute lymphoblastic leukemia risk in case-parent triads. (24367687)
2013
4
Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children's oncology group studies: a report from the children's oncology group. (23940221)
2013
5
CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors. (24382688)
2013
6
The NR4A orphan nuclear receptors do not confer prednisolone resistance in pediatric acute lymphoblastic leukemia. (24056879)
2013
7
CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia. (22261446)
2012
8
Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. (22653976)
2012
9
Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. (21261497)
2011
10
Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia. (21828118)
2011
11
Presentation and outcomes for children with bone marrow necrosis and acute lymphoblastic leukemia: a literature review. (21941136)
2011
12
RUNX1 amplification in B-cell acute lymphoblastic leukemia. (20001241)
2010
13
Pharmacogenomic variations in treatment protocols for childhood acute lymphoblastic leukemia. (19774638)
2010
14
Overt testicular disease at diagnosis in childhood acute lymphoblastic leukemia: prognostic significance and role of testicular irradiation. (20589462)
2010
15
Dense methylation of types 1 and 2 regulatory regions of the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene. (20051780)
2010
16
Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia. (19148136)
2009
17
Persistent hypokalemia in an acute lymphoblastic leukemia patient. (20838546)
2009
18
Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells. (18955159)
2009
19
Resistance to TRAIL-induced apoptosis caused by constitutional phosphorylation of Akt and PTEN in acute lymphoblastic leukemia cells. (18599181)
2008
20
Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathways. (18322253)
2008
21
Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia. (18079736)
2008
22
Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region. (17690704)
2007
23
MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients. (17512587)
2007
24
Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines. (17560996)
2007
25
Hepatocyte growth factor receptor c-MET is associated with FAS and when activated enhances drug-induced apoptosis in pediatric B acute lymphoblastic leukemia with TEL-AML1 translocation. (17673463)
2007
26
Troglitazone inhibits cell growth and induces apoptosis of B-cell acute lymphoblastic leukemia cells with t(14;18). (16809887)
2006
27
Chemokine IL-8 and chemokine receptor CXCR3 and CXCR4 gene expression in childhood acute lymphoblastic leukemia at first relapse. (16679918)
2006
28
Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells. (16520989)
2006
29
High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia. (16424867)
2006
30
Acquired Glanzmann's thrombasthenia associated with acute lymphoblastic leukemia. (16217260)
2005
31
Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia. (15201966)
2004
32
Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression. (12127395)
2002
33
Hematopoietic stem cell transplantation with conditioning regimens containing melphalan in pediatric patients with acute lymphoblastic leukemia]. (12229121)
2002
34
TEL rearrangements in acute lymphoblastic leukemia: association with p16 deletions in relapsed cases. (11410424)
2001
35
The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case. (11406533)
2001
36
Surfactant protein D and KL-6 as serologic indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia. (11321887)
2001
37
Promoter analysis of TFPT (FB1), a molecular partner of TCF3 (E2A) in childhood acute lymphoblastic leukemia. (11700047)
2001
38
AML1 gene amplification: a novel finding in childhood acute lymphoblastic leukemia. (10756360)
2000
39
Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia. (10695821)
2000
40
High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. (10397743)
1999
41
The prognostic significance of p16INK4a/p14ARF and p15INK4b deletions in adult acute lymphoblastic leukemia. (10430092)
1999
42
The IL-6 gene expression by leukemic cells from acute lymphoblastic leukemia common and T type and modulation of IL-6 production by TNF. (9728802)
1998
43
Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy. (9748136)
1998
44
Myeloperoxidase positive acute lymphoblastic leukemia cell lines, NALM-30, NALM-31 and NALM-32, carrying Philadelphia chromosome with biphenotypic characteristics. (10363160)
1998
45
Asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia. (9058708)
1997
46
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
47
Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias. (8637234)
1996
48
Characterization of a 14q+ marker chromosome in philadelphia chromosome positive acute lymphoblastic leukemia by DNA analysis and fluorescence in situ hybridization. (7773965)
1995
49
Shedding of CD9 antigen into cerebrospinal fluid by acute lymphoblastic leukemia cells. (2364164)
1990
50
Acute non-lymphoblastic leukemia. Correlation between clinical and hematological parameters in 87 adult patients. (3121464)
1987

Variations for Lymphoblastic Leukemia

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Expression for genes affiliated with Lymphoblastic Leukemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoblastic Leukemia

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Pathways for genes affiliated with Lymphoblastic Leukemia

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51PathCards, 56Reactome, 5Cell Signaling Technology, 31KEGG
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Pathways related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1TCF3, MEF2D
29.6BLNK, FLI1, TCF3, PBX1, IKZF1
39.3LMO2, FLI1, FLT3, TSPAN7, TCF3, PBX1

Compounds for genes affiliated with Lymphoblastic Leukemia

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GO Terms for genes affiliated with Lymphoblastic Leukemia

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17Gene Ontology
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Cellular components related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:00566710.0PBX1, TCF3, LMO2
2nucleusGO:0056347.9ARID5B, PICALM, MLLT4, AFF4, LMO2, FLI1

Biological processes related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1Peyers patch developmentGO:04854110.4IKZF1, TCF3
2natural killer cell differentiationGO:00177910.4TCF3, IKZF1
3cell developmentGO:04846810.3ARID5B, TCF3
4thalamus developmentGO:02179410.3OLIG2, TAL2
5embryonic hemopoiesisGO:03516210.2PBX1, LMO2
6adrenal gland developmentGO:03032510.1PBX1, ARID5B
7negative regulation of neuron differentiationGO:04566510.1OLIG2, PBX1
8thymus developmentGO:04853810.1IKZF1, PBX1
9B cell differentiationGO:03018310.0IKZF1, LYL1, TCF3, FLT3, BLNK
10positive regulation of transcription from RNA polymerase II promoterGO:0459449.9BCL9, MEF2D, IKZF1, TCF3, LMO2
11skeletal muscle cell differentiationGO:0359149.8BCL9, MEF2D

Molecular functions related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:04342510.2LMO2, TCF3
2protein dimerization activityGO:04698310.0TAL2, MEF2D, LYL1
3sequence-specific DNA binding RNA polymerase II transcription factor activityGO:00098110.0MEF2D, FLI1, LMO2
4RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.0LMO2, MEF2D
5protein heterodimerization activityGO:04698210.0TPD52L2, TCF3, PBX1, IKZF1
6E-box bindingGO:0708889.9TCF3, LMO2
7sequence-specific DNA bindingGO:0435659.8IKZF1, PBX1, TCF3, FLI1
8protein homodimerization activityGO:0428039.8OLIG2, TCF3, FLT3, TPD52L2
9sequence-specific DNA binding transcription factor activityGO:0037009.5AFF4, FLI1, TCF3, PBX1, IKZF1, MEF2D
10DNA bindingGO:0036779.3FLI1, TCF3, PBX1, LYL1, IKZF1, OLIG2
11protein bindingGO:0055158.5ARID5B, PICALM, MLLT4, BLNK, AFF4, TPD52L2

Products for genes affiliated with Lymphoblastic Leukemia

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Sources for Lymphoblastic Leukemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet