MCID: LYM026
MIFTS: 55

Lymphoblastic Leukemia malady

Genetic diseases, Immune diseases, Rare diseases, Cancer diseases, Blood diseases categories

Aliases & Classifications for Lymphoblastic Leukemia

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Lymphoblastic Leukemia, Aliases & Descriptions:

Name: Lymphoblastic Leukemia 9 11
Precursor Cell Lymphoblastic Leukemia Lymphoma 60
 
Acute Lymphocytic Leukemia 60
Lymphoid Leukemia 60


Classifications:



External Ids:

Disease Ontology9 DOID:1037
NCIt38 C7539
MeSH33 D007945
ICD9CM27 204.9, 204

Summaries for Lymphoblastic Leukemia

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Disease Ontology:9 A leukemia that has material basis in lymphoblasts (immature white blood cells).

MalaCards based summary: Lymphoblastic Leukemia, also known as precursor cell lymphoblastic leukemia lymphoma, is related to leukemia and precursor b-cell acute lymphoblastic leukemia. An important gene associated with Lymphoblastic Leukemia is TSPAN7 (tetraspanin 7), and among its related pathways are CDO in myogenesis and Lymphocyte Signaling. The drugs mercaptopurine and asparaginase have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Related Diseases for Lymphoblastic Leukemia

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Diseases in the Lymphoblastic Leukemia family:

Leukemia, Acute Lymphoblastic Leukemia, Acute Lymphoblastic 3

Diseases related to Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 351)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.2OLIG2, ABCC5, PICALM, MLLT4, BLNK, LMO2
2precursor b-cell acute lymphoblastic leukemia31.7PBX1, FLT3
3lymphoblastic lymphoma31.7FLI1, LMO2
4precursor t-cell acute lymphoblastic leukemia31.3IKZF1, LYL1, FLT3, LMO2, PICALM
5acute leukemia31.3MLLT4, LMO2, FLT3, PBX1, LYL1
6leukemia, acute lymphoblastic31.1ABCC5, PICALM, BLNK, LMO2, FLT3, TCF3
7burkitt lymphoma30.7PICALM, BLNK, LMO2, FLI1, FLT3, PBX1
8breast cancer30.6ABCC5, TPD52L2, LMO2, FLI1, FLT3, PBX1
9acute non lymphoblastic leukemia11.0
10myeloid leukemia10.8
11glucocorticoid resistance10.7
12hematopoietic stem cell transplantation10.7
13childhood leukemia10.7
14hypercalcemia10.6
15sarcoma10.6
16myelodysplastic syndrome10.5
17wilms tumor10.5
18down syndrome10.5
19endotheliitis10.5
20acute lymphoblastic leukemia, childhood10.5
21bone marrow necrosis10.5
22hemophagocytic lymphohistiocytosis10.5
23osteonecrosis10.5
24eosinophilia10.5
25retinitis10.5
26obesity10.5
27hepatitis10.5
28neutropenia10.5
29pancreatitis10.5
30ataxia-telangiectasia10.4
31hypertriglyceridemia10.4
32hodgkin lymphoma10.4
33chronic lymphocytic leukemia10.4
34fusariosis10.4
35cerebritis10.4
36hyperphosphatemia10.4
37acute t cell leukemia10.4
38ataxia10.4
39histiocytic sarcoma10.4
40dysembryoplastic neuroepithelial tumor10.4OLIG2
41bacteremia10.4
42arthritis10.4
43influenza10.4
44meningitis10.4
45neuropathy10.4
46nijmegen breakage syndrome10.3
47b-cell lymphomas10.3
48chronic myelomonocytic leukemia10.3
49myelofibrosis10.3
50severe congenital neutropenia10.3

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia:



Diseases related to lymphoblastic leukemia

Symptoms for Lymphoblastic Leukemia

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Drugs & Therapeutics for Lymphoblastic Leukemia

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Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Leukemia

Search NIH Clinical Center for Lymphoblastic Leukemia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Lymphoblastic Leukemia

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Anatomical Context for Lymphoblastic Leukemia

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MalaCards organs/tissues related to Lymphoblastic Leukemia:

31
T cells, B cells, Bone, Bone marrow, Myeloid, B lymphoblasts, Endothelial, Lung, Breast, Brain, Monocytes, Liver, Thymus, Thyroid, Spleen, Whole blood, Kidney, Testes, Neutrophil, Spinal cord, Colon, Skin, Uterus, Placenta, Prostate, Cervix, Tonsil, Temporal lobe, Tongue, Appendix, Pineal, Pituitary

Animal Models for Lymphoblastic Leukemia or affiliated genes

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MGI Mouse Phenotypes related to Lymphoblastic Leukemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.6IKZF1, PBX1, FLI1, LMO2, PICALM
2MP:00020069.3BLNK, LMO2, FLI1, FLT3, TCF3, IKZF1
3MP:00053808.9PICALM, MLLT4, AFF4, LMO2, FLI1, TCF3
4MP:00053878.8PICALM, BLNK, LMO2, FLI1, FLT3, TCF3
5MP:00053848.7ABCC5, PICALM, BLNK, LMO2, FLI1, FLT3
6MP:00053978.5PICALM, BLNK, AFF4, LMO2, FLI1, FLT3
7MP:00053788.3ARID5B, PICALM, MLLT4, AFF4, TPD52L2, LMO2
8MP:00107688.1FLI1, LMO2, AFF4, BLNK, MLLT4, PICALM

Publications for Lymphoblastic Leukemia

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Articles related to Lymphoblastic Leukemia:

(show top 50)    (show all 2819)
idTitleAuthorsYear
1
Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A. (25903014)
2015
2
Acute lymphoblastic leukemia with eosinophilia lacking peripheral blood leukemic cell: a rare entity. (25332543)
2014
3
Methodological aspects of minimal residual disease assessment by flow cytometry in acute lymphoblastic leukemia: A french multicenter study. (25363877)
2014
4
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
5
Prognostic value of plasma levels of thrombomodulin and von Willebrand factor in Egyptian children with acute lymphoblastic leukemia. (24243921)
2013
6
Using a bayesian hierarchical model for identifying single nucleotide polymorphisms associated with childhood acute lymphoblastic leukemia risk in case-parent triads. (24367687)
2013
7
Intrachromosomal amplification of chromosome 21 is associated with inferior outcomes in children with acute lymphoblastic leukemia treated in contemporary standard-risk children's oncology group studies: a report from the children's oncology group. (23940221)
2013
8
CDKN1A-mediated responsiveness of MLL-AF4-positive acute lymphoblastic leukemia to Aurora kinase-A inhibitors. (24382688)
2013
9
The NR4A orphan nuclear receptors do not confer prednisolone resistance in pediatric acute lymphoblastic leukemia. (24056879)
2013
10
CD117 expression is a sensitive but nonspecific predictor of FLT3 mutation in T acute lymphoblastic leukemia and T/myeloid acute leukemia. (22261446)
2012
11
Bortezomib with chemotherapy is highly active in advanced B-precursor acute lymphoblastic leukemia: Therapeutic Advances in Childhood Leukemia & Lymphoma (TACL) Study. (22653976)
2012
12
Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. (21261497)
2011
13
Precursor T-Cell acute lymphoblastic leukemia/lymphoma with rare presentation in the urinary bladder. (22184539)
2011
14
Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia. (21828118)
2011
15
RUNX1 amplification in B-cell acute lymphoblastic leukemia. (20001241)
2010
16
Pharmacogenomic variations in treatment protocols for childhood acute lymphoblastic leukemia. (19774638)
2010
17
Overt testicular disease at diagnosis in childhood acute lymphoblastic leukemia: prognostic significance and role of testicular irradiation. (20589462)
2010
18
Dense methylation of types 1 and 2 regulatory regions of the CD10 gene promoter in infant acute lymphoblastic leukemia with MLL/AF4 fusion gene. (20051780)
2010
19
Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia. (19148136)
2009
20
Persistent hypokalemia in an acute lymphoblastic leukemia patient. (20838546)
2009
21
Compromised repair of clustered DNA damage in the human acute lymphoblastic leukemia MSH2-deficient NALM-6 cells. (18955159)
2009
22
Resistance to TRAIL-induced apoptosis caused by constitutional phosphorylation of Akt and PTEN in acute lymphoblastic leukemia cells. (18599181)
2008
23
Bone marrow stromal cells and the upregulation of interleukin-8 production in human T-cell acute lymphoblastic leukemia through the CXCL12/CXCR4 axis and the NF-kappaB and JNK/AP-1 pathways. (18322253)
2008
24
Monoallelic or biallelic LMO2 expression in relation to the LMO2 rearrangement status in pediatric T-cell acute lymphoblastic leukemia. (18079736)
2008
25
Combined high-resolution array-based comparative genomic hybridization and expression profiling of ETV6/RUNX1-positive acute lymphoblastic leukemias reveal a high incidence of cryptic Xq duplications and identify several putative target genes within the commonly gained region. (17690704)
2007
26
MTHFR polymorphisms' influence on outcome and toxicity in acute lymphoblastic leukemia patients. (17512587)
2007
27
Notch signaling induces SKP2 expression and promotes reduction of p27Kip1 in T-cell acute lymphoblastic leukemia cell lines. (17560996)
2007
28
Hepatocyte growth factor receptor c-MET is associated with FAS and when activated enhances drug-induced apoptosis in pediatric B acute lymphoblastic leukemia with TEL-AML1 translocation. (17673463)
2007
29
Troglitazone inhibits cell growth and induces apoptosis of B-cell acute lymphoblastic leukemia cells with t(14;18). (16809887)
2006
30
Chemokine IL-8 and chemokine receptor CXCR3 and CXCR4 gene expression in childhood acute lymphoblastic leukemia at first relapse. (16679918)
2006
31
Hypoxia-mediated fenretinide (4-HPR) resistance in childhood acute lymphoblastic leukemia cells. (16520989)
2006
32
High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia. (16424867)
2006
33
Acquired Glanzmann's thrombasthenia associated with acute lymphoblastic leukemia. (16217260)
2005
34
Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia. (15201966)
2004
35
Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression. (12127395)
2002
36
Hematopoietic stem cell transplantation with conditioning regimens containing melphalan in pediatric patients with acute lymphoblastic leukemia]. (12229121)
2002
37
TEL rearrangements in acute lymphoblastic leukemia: association with p16 deletions in relapsed cases. (11410424)
2001
38
The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case. (11406533)
2001
39
Surfactant protein D and KL-6 as serologic indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia. (11321887)
2001
40
AML1 gene amplification: a novel finding in childhood acute lymphoblastic leukemia. (10756360)
2000
41
High frequency of adhesion defects in B-lineage acute lymphoblastic leukemia. (10397743)
1999
42
The IL-6 gene expression by leukemic cells from acute lymphoblastic leukemia common and T type and modulation of IL-6 production by TNF. (9728802)
1998
43
Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy. (9748136)
1998
44
Myeloperoxidase positive acute lymphoblastic leukemia cell lines, NALM-30, NALM-31 and NALM-32, carrying Philadelphia chromosome with biphenotypic characteristics. (10363160)
1998
45
Asparaginase-associated lipid abnormalities in children with acute lymphoblastic leukemia. (9058708)
1997
46
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
47
Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias. (8637234)
1996
48
Characterization of a 14q+ marker chromosome in philadelphia chromosome positive acute lymphoblastic leukemia by DNA analysis and fluorescence in situ hybridization. (7773965)
1995
49
Shedding of CD9 antigen into cerebrospinal fluid by acute lymphoblastic leukemia cells. (2364164)
1990
50
Acute non-lymphoblastic leukemia. Correlation between clinical and hematological parameters in 87 adult patients. (3121464)
1987

Variations for Lymphoblastic Leukemia

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Expression for genes affiliated with Lymphoblastic Leukemia

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Search GEO for disease gene expression data for Lymphoblastic Leukemia.

Pathways for genes affiliated with Lymphoblastic Leukemia

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Pathways related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.1MEF2D, TCF3
29.6BLNK, FLI1, TCF3, PBX1, IKZF1
39.3LYL1, PBX1, TCF3, TSPAN7, FLT3, FLI1

Compounds for genes affiliated with Lymphoblastic Leukemia

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GO Terms for genes affiliated with Lymphoblastic Leukemia

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Cellular components related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:000566710.0PBX1, TCF3, LMO2
2nucleusGO:00056347.9ARID5B, PICALM, MLLT4, AFF4, LMO2, FLI1

Biological processes related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1Peyers patch developmentGO:004854110.4IKZF1, TCF3
2natural killer cell differentiationGO:000177910.4TCF3, IKZF1
3cell developmentGO:004846810.3ARID5B, TCF3
4thalamus developmentGO:002179410.3OLIG2, TAL2
5embryonic hemopoiesisGO:003516210.2PBX1, LMO2
6adrenal gland developmentGO:003032510.1PBX1, ARID5B
7negative regulation of neuron differentiationGO:004566510.1OLIG2, PBX1
8thymus developmentGO:004853810.1IKZF1, PBX1
9B cell differentiationGO:003018310.0IKZF1, LYL1, TCF3, FLT3, BLNK
10positive regulation of transcription from RNA polymerase II promoterGO:00459449.9BCL9, MEF2D, IKZF1, TCF3, LMO2
11skeletal muscle cell differentiationGO:00359149.8BCL9, MEF2D

Molecular functions related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:004342510.2LMO2, TCF3
2protein dimerization activityGO:004698310.0TAL2, MEF2D, LYL1
3sequence-specific DNA binding RNA polymerase II transcription factor activityGO:000098110.0MEF2D, FLI1, LMO2
4RNA polymerase II regulatory region sequence-specific DNA bindingGO:000097710.0LMO2, MEF2D
5protein heterodimerization activityGO:004698210.0TPD52L2, TCF3, PBX1, IKZF1
6E-box bindingGO:00708889.9TCF3, LMO2
7sequence-specific DNA bindingGO:00435659.8IKZF1, PBX1, TCF3, FLI1
8protein homodimerization activityGO:00428039.8OLIG2, TCF3, FLT3, TPD52L2
9sequence-specific DNA binding transcription factor activityGO:00037009.5AFF4, FLI1, TCF3, PBX1, IKZF1, MEF2D
10DNA bindingGO:00036779.3FLI1, TCF3, PBX1, LYL1, IKZF1, OLIG2
11protein bindingGO:00055158.5ARID5B, PICALM, MLLT4, BLNK, AFF4, TPD52L2

Products for genes affiliated with Lymphoblastic Leukemia

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Sources for Lymphoblastic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet