Lymphoblastic Leukemia malady

MalaCards: Lymphoblastic Leukemia, also known as acute lymphocytic leukemia, is related to leukemia and prostatitis. An important gene associated with Lymphoblastic Leukemia is LYL1 (lymphoblastic leukemia derived sequence 1), and among its related pathways are Antioxidant Action of Vitamin-C and Pathways in cancer. The compounds calcium and oxygen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are cellular and mortality/aging.

Aliases & Descriptions:

lymphoblastic leukemia 6 8 acute lymphocytic leukemia 43

Diseases related to lymphoblastic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 887)

id	Related Disease	Score	Top Affiliating Genes
1	leukemia	151.8	ZNF230, ZNF384, ZNF521, PIK3CA, PICALM, PIK3CG
2	prostatitis	94.7	PIK3CA, PIK3CG, LRP5, KLF10, KLF5, RFC1
3	myeloid leukemia	93.0	PIK3CA, PICALM, PIK3CG, LRP5, KLF5, NCAM1
4	acute lymphoblastic leukemia	89.5	PICALM, COG2, RECK, KIT, KITLG, KIR3DL1
5	acute myeloid leukemia	82.5	PIK3CA, PICALM, PIK3CG, LRP5, KLF5, NCAM1
6	lymphocytic leukemia	82.3	PIK3CA, PIK3CG, NCAM1, RECK, RELA, KIT
7	thyroiditis	79.6	PIK3CA, PICALM, PIK3CG, COG2, KLF10, RFC1
8	acute leukemia	77.7	ZNF384, PIK3CA, PICALM, NCAM1, KIT, KITLG
9	sarcoma	72.6	ZNF384, PIK3CA, PIK3CG, NCAM1, NCOA3, RECK
10	neuroblastoma	72.1	PIK3CA, PIK3CG, NCAM1, RECK, RELA, KIT
11	carcinoma	67.6	ZNF384, PIK3CA, PIK3CG, LRP5, KLF10, KLF5
12	hypoxia	62.8	PIK3CA, PIK3CG, LRP5, KLF5, RECK, RELA
13	alzheimer's disease	62.3	PIK3CA, PICALM, PIK3CG, COG2, RFC1, NCAM1
14	cholesterol	61.2	PIK3CA, PIK3CG, LRP5, COG2, KLF5, NCOA3
15	cerebritis	61.1	PIK3CG, COG2, NCAM1, RELA, CNTNAP2, KITLG
16	anemia	60.8	NCAM1, RELA, KIT, KITLG, VWF, PCNA
17	leukemia/lymphoma	57.0	PIK3CA, PIK3CG, RFC1, KITLG, RB1, NBN
18	retinoblastoma	56.5	PIK3CA, PIK3CG, RFC1, NCAM1, RECK, KIT
19	non-hodgkin lymphoma	55.0	KITLG, NBN, SELL, NAT1, NAT2, VDR
20	obesity	54.8	PIK3CA, PIK3CG, LRP5, COG2, NCOA3, RECK
21	neuronitis	52.3	ZNF384, PIK3CA, PICALM, PIK3CG, KLF10, NCAM1
22	pneumonia	52.1	COG2, RELA, SFTPD, BTK, SELL, SERPINC1
23	hypertension	51.5	PIK3CG, LRP5, COG2, KLF5, RFC1, NCAM1
24	chronic myeloid leukemia	51.4	PIK3CG, KIT, KITLG, KIR3DL1, SELP, MYC
25	pancreatitis	50.8	PIK3CA, PIK3CG, LRP5, KLF10, KLF5, NCAM1
26	hematopoiesis	50.8	PIK3CG, NCOA3, KIT, KITLG, PCNA, RB1
27	chronic lymphocytic leukemia	49.4	SELL, BRCA2, LPL, MYB, BIRC2, BIRC5
28	influenza	48.9	PIK3CA, PIK3CG, RECK, RELA, SFTPD, SELL
29	adenocarcinoma	48.3	PIK3CA, PIK3CG, KLF10, NCAM1, NCOA3, RECK
30	thyroid cancer	48.3	PIK3CA, PIK3CG, RFC1, NCOA3, KIT, PCNA
31	b-cell lymphomas	47.8	BTK, RB1, NBN, MYC, MYCN, BMI1
32	melanoma	47.5	PIK3CA, PIK3CG, KLF5, NCAM1, NCOA3, RECK
33	wilms tumor	47.2	NCAM1, VWF, PCNA, SET, BRCA2, VEGFA
34	burkitt's lymphoma	46.9	MYC, MYCN, MYB, MYBL1, BMI1, BMP6
35	acute lymphocytic leukemia	46.6	RB1, SERPINC1, VEGFA, VEGFC, LPL, MYC
36	myeloma	45.9	PIK3CA, PIK3CG, LRP5, NCAM1, RECK, RELA
37	hepatocellular carcinoma	45.8	ZNF384, PIK3CA, PIK3CG, NCAM1, NCOA3, RECK
38	neutropenia	45.5	KITLG, BTK, BIRC5, BCL2, LEF1, UGT1A1
39	arthritis	45.2	PIK3CG, LRP5, KLF5, RFC1, RECK, RELA
40	hodgkin's lymphoma	45.2	PIK3CG, SELP, SERPINB9, BSG, BRCA2, BMI1
41	insulin resistance	45.1	PIK3CA, PIK3CG, COG2, RELA, VWF, SELL
42	gastric cancer	44.9	PIK3CA, PIK3CG, KLF5, RFC1, NCOA3, RECK
43	myelodysplastic syndrome	44.9	KIT, KITLG, KIR3DL1, SELL, VDR, BMI1
44	noonan syndrome	44.7	PIK3CG, NCAM1, KITLG, VWF, PCNA, SELP
45	thrombosis	44.2	PIK3CG, COG2, RFC1, RECK, VWF, PCNA
46	rheumatoid arthritis	43.8	PIK3CG, LRP5, KLF5, RFC1, RECK, RELA
47	twinning	43.6	COG2, NCAM1, VWF, BTK, SERPINC1, SERPINE1
48	soft tissue sarcoma	43.5	KIT, KITLG, PCNA, RB1, SERPINE1, VEGFA
49	severe combined immunodeficiency	42.9	KITLG, PCNA, SELP, VEGFA, LMO2, MYC
50	homocysteine	42.8	COG2, RFC1, RELA, VWF, PCNA, SELP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to lymphoblastic leukemia:

²²

MGI Mouse Phenotypes related to lymphoblastic leukemia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	46.1	PIK3CA, PICALM, PIK3CG, LRP5, KLF10, KLF5
2	mortality/aging	MP:0010768	41.4	PIK3CA, PICALM, LRP5, KLF5, NCAM1, RECK
3	homeostasis/metabolism phenotype	MP:0005376	41.3	PIK3CA, PICALM, PIK3CG, LRP5, KLF10, KLF5
4	growth/size phenotype	MP:0005378	40.2	ZNF384, ZNF521, PIK3CA, PICALM, PIK3CG, KLF5
5	immune system phenotype	MP:0005387	34.2	PICALM, LRP5, KLF5, NCOA3, KIT, VWF
6	hematopoietic system phenotype	MP:0005397	34.0	PICALM, KIT, SFRP1, PCNA, VPREB1, BTK
7	cardiovascular system phenotype	MP:0005385	32.4	PIK3CA, PIK3CG, LRP5, KLF5, RECK, RELA
8	nervous system phenotype	MP:0003631	30.6	LRP5, RECK, RELA, CNTNAP2, KIT, KITLG
9	tumorigenesis	MP:0002006	26.5	PIK3CA, KLF10, NCOA3, KIT, KITLG, BTK
10	integument phenotype	MP:0010771	26.4	PIK3CG, KLF10, NCOA3, RECK, RELA, CNTNAP2
11	normal phenotype	MP:0002873	25.9	LRP5, KLF5, RELA, SFRP5, SEZ6L2, NAT1
12	behavior/neurological phenotype	MP:0005386	25.4	PIK3CA, LRP5, NCAM1, NCOA3, CNTNAP2, KIT
13	embryogenesis phenotype	MP:0005380	24.8	PIK3CA, PICALM, LRP5, KLF5, NCOA3, RECK
14	skeleton phenotype	MP:0005390	24.4	ZNF384, ZNF521, PIK3CG, KLF10, RECK, RELA
15	digestive/alimentary phenotype	MP:0005381	23.2	KLF5, NCOA3, KIT, KITLG, VWF, BTK
16	vision/eye phenotype	MP:0005391	22.8	PIK3CA, LRP5, NCAM1, RELA, KIT, KITLG
17	reproductive system phenotype	MP:0005389	21.6	ZNF384, PIK3CA, NCOA3, SFRP5, NBN, SEPT4
18	muscle phenotype	MP:0005369	21.1	PIK3CA, PIK3CG, KLF5, NCOA3, RELA, KIT
19	renal/urinary system phenotype	MP:0005367	21.1	NCOA3, KIT, RBPJ, SELP, BRAF, LMO2
20	liver/biliary system phenotype	MP:0005370	19.4	PICALM, LRP5, NCOA3, RECK, KIT, SERPINC1
21	limbs/digits/tail phenotype	MP:0005371	19.2	LRP5, KLF10, RECK, RELA, KIT, KITLG
22	endocrine/exocrine gland phenotype	MP:0005379	18.8	ZNF384, LRP5, KLF5, SFRP5, RBPJ, NBN
23	craniofacial phenotype	MP:0005382	18.2	ZNF521, LRP5, NCOA3, KIT, KITLG, NBN
24	hearing/vestibular/ear phenotype	MP:0005377	17.9	NCOA3, KIT, KITLG, RB1, VDR, MYC
25	respiratory system phenotype	MP:0005388	17.6	KLF5, SFTPD, RBPJ, SELL, SELP, LPL
26	no phenotypic analysis	MP:0003012	17.0	SFRP1, PCNA, RB1, VEGFA, BNC1, MYC
27	adipose tissue phenotype	MP:0005375	16.0	PIK3CA, NCOA3, SFRP1, RB1, SERPINE1, BRAF
28	pigmentation phenotype	MP:0001186	14.0	LRP5, KIT, KITLG, RB1, RBPJ, SERPINC1
29	other phenotype	MP:0005395	13.1	RECK, RARA, RARB, PBX1, KDR, LEPR

Articles related to lymphoblastic leukemia:

(show top 50)    (show all 1459)

id	Title	Authors	Year	Affiliating Genes
1	Insights into the cellular origin and etiology of the infant pro-B acute lymphoblastic leukemia with MLL-AF4 rearrangement. (21135858)	Bueno C.... Menendez P.	2011	MLL, AFF1
2	NOTCH1 and FBXW7 mutations have a favorable impact on early response to treatment, but not on outcome, in children with T-cell acute lymphoblastic leukemia (T-ALL) treated on EORTC trials 58881 and 58951. (20861920)	Clappier E.... CavAc H.	2010	NOTCH1, FBXW7
3	The MIF -173G/C polymorphism and risk of childhood ac ute lymphoblastic leukemia in a Chinese population. (20447688)	Xue Y.... Fang Y.	2010	MIF
4	Pharmacogenomic variations in treatment protocols for childhood acute lymphoblastic leukemia. (19774638)	Yang Y.L.... Hu C.Y.	2010	TYMS, CCND1, GSTT1
5	Incidence and diversity of PAX5 fusion genes in childhood acute lymphoblastic leukemia. (19020546)	Nebral K.... Strehl S.	2009	PAX5
6	Inhibition of glycolysis modulates prednisolone resis tance in acute lymphoblastic leukemia cells. (18978206)	Hulleman E.... den Boer M.L.	2009	GAPDH
7	A novel translocation t(1;5)(p32;q31) that was not as sociated with the TAL1 rearrangement in a case of T lymphoblastic leukemia/lymp homa. (19571616)	Cho H.S.... Bae Y.K.	2009	TAL1
8	Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells. (19054556)	Akagi T.... Koeffler H.P.	2009	ASNS
9	Expression of cyclin A in childhood acute lymphoblastic leukemia cells reveals undisturbed G1-S phase transition and passage through the S phase. (18668132)	Hirt A.... Leibundgut K.	2009	CCNA2
10	Translocation (14;14)(q11;q32) with simultaneous involvement of the IGH and CEBPE genes in B-lineage acute lymphoblastic leukemia. (19027493)	Han Y.... Bai S.	2008	TCL1A
11	Mechanism of synergy of N-(4-hydroxyphenyl)retinamide and ABT-737 in acute lymphoblastic leukemia cell lines: Mcl-1 inactivation. (18398104)	Kang M.H.... Reynolds C.P.	2008	BCL2, MAPK8
12	Genomewide identification of prednisolone-responsive genes in acute lymphoblastic leukemia cells. (17218380)	Tissing W.J.... Pieters R.	2007	TXNIP
13	The T1790A BRAF mutation (L597Q) in childhood acute lymphoblastic leukemia is a functional oncogene. (17525723)	Hou P.... Xing M.	2007	BRAF
14	Down-regulation of DLX3 expression in MLL-AF4 childhood lymphoblastic leukemias is mediated by promoter region hypermethylation. (17611665)	Campo Dell'Orto M.... Basso G.	2007	DLX3
15	MDR1 gene variants, indoor insecticide exposure, and the risk of childhood acute lymphoblastic leukemia. (17548681)	Urayama K.Y.... Wiemels J.L.	2007	ABCB1
16	P38 mitogen-activated protein kinase mediates glucocorticoid receptor function induced by dexamethasone in acute lymphoblastic leukemia cells (18021564)	He L.... Liu Y.P.	2007	MAPK12, MAPK14, NR3C1
17	PTHrP-independent hypercalcemia with increased proinflammatory cytokines and bone resorption in two children with CD19-negative precursor B acute lymphoblastic leukemia. (16496289)	Niizuma H.... Imaizumi M.	2007	PTHLH
18	Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia. (17640858)	Troeger A.... Dilloo D.	2007	BIRC5
19	c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. (16847353)	Weng A.P.... Aster J.C.	2006	MYC
20	Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage. (16118018)	Corcione A.... Pistoia V.	2006	CCR1, CCR7, CXCR1
21	The dioxin receptor is silenced by promoter hypermethylation in human acute lymphoblastic leukemia through inhibition of Sp1 binding. (16410262)	Mulero-Navarro S.... Fernandez-Salguero P.M.	2006	AHR, ARNT, SP1
22	GSTP1 and MDR1 genotypes and central nervous system relapse in childhood acute lymphoblastic leukemia. (15717687)	Stanulla M.... Schwab M.	2005	GSTP1, ABCB1
23	Role of 5'-nucleotidase in thiopurine metabolism: enzyme kinetic profile and association with thio-GMP levels in patients with acute lymphoblastic leukemia during 6-mercaptopurine treatment. (15990089)	Brouwer C.... De Abreu R.A.	2005	NT5E
24	MDM2 promoter variation and age of diagnosis of acute lymphoblastic leukemia. (16167062)	Swinney R.M.... Tomlinson G.E.	2005	MDM2
25	Fusion of EML1 to ABL1 in T-cell acute lymphoblastic leukemia with cryptic t(9;14)(q34;q32). (15713800)	De Keersmaecker K.... Cools J.	2005	ABL1, STAT5B, CDKN2A
26	Cytokine/cytokine receptor gene expression in childhood acute lymphoblastic leukemia: correlation of expression and clinical outcome at first disease recurrence. (15651075)	Wu S.... Seeger K.	2005	IL18, IFNG, IL10
27	Insulin-like growth factor binding protein-2 at diagnosis of childhood acute lymphoblastic leukemia and the prediction of relapse risk. (15687344)	Vorwerk P.... Mittler U.	2005	IGFBP2, IGFBP1
28	T cell receptor gamma (TCRG) gene rearrangements in B razilian children with acute lymphoblastic leukemia: analysis and implications for the study of minimal residual disease. (14687622)	Scrideli C.A.... Tone L.G.	2004	TRG@
29	Various types of rearrangements target TLX3 locus in T-cell acute lymphoblastic leukemia. (15334547)	Su X.Y.... Bernard O.A.	2004	TLX3
30	Mature B-cell acute lymphoblastic leukemia with t(9;11) translocation: a distinct subset of B-cell acute lymphoblastic leukemia. (15098014)	Tsao L.... Alobeid B.	2004	MYC, MLL
31	Hemostatic side effects of high-dose methotrexate in childhood acute lymphoblastic leukemia. (14660309)	Fisgin T.... Duru F.	2004	F9
32	Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. (15353558)	Barata J.T.... Boussiotis V.A.	2004	PIK3CG, IL7
33	Influence of functional polymorphisms of the MDR1 gene on vincristine pharmacokinetics in childhood acute lymphoblastic leukemia. (15371983)	Plasschaert S.L.... de Bont E.S.	2004	ABCB1
34	Suppression of adrenal function in children with acut e lymphoblastic leukemia following induction therapy with corticosteroid and ot her cytotoxic agents. (15192618)	Mahachoklertwattana P.... Okascharoen C.	2004	POMC
35	Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia indicates subclone formation during early stages of leukemia development. (14695996)	Peham M.... Panzer-GrA1mayer E.R.	2004	ETV6
36	Is B-lineage acute lymphoblastic leukemia with a mature phenotype and l1 morphology a precursor B-lymphoblastic leukemia/lymphoma or Burkitt leukemia/lymphoma? (14521459)	Li S.... Lew G.	2003	MYC
37	A mathematical model of in vivo methotrexate accumulation in acute lymphoblastic leukemia. (12439601)	Panetta J.C.... Relling M.V.	2002	FPGS, GGH
38	Expression of metastasis associated proteins, CD44v6 and NM23-H1, in pediatric acute lymphoblastic leukemia. (11299850)	Magyarosy E.... TimA!r J.	2001	NME1
39	Pro-B-cell to pre-B-cell development in B-lineage acute lymphoblastic leukemia expressing the MLL/AF4 fusion protein. (11719380)	Bertrand F.E.... LeBien T.W.	2001	AFF1
40	Spleen tyrosine kinase (Syk) deficiency in childhood pro-B cell acute lymphoblastic leukemia. (11494125)	Goodman P.A.... Uckun F.M.	2001	SYK
41	Acute lymphoblastic leukemia accompanied by chromosomal abnormality of translocation (12;17). (11855782)	Asahara S.I.... Tatsumi E.	2001	ANPEP
42	Expression of B cell-associated transcription factors in B-cell precursor acute lymphoblastic leukemia cells: association with PU.1 expression, phenotype, and immunogenotype. (10905058)	Nishii K.... Shiku H.	2000	PAX5, POU2F2
43	Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia. (10942239)	Verhagen O.J.... van der Schoot C.E.	2000	IGH@
44	Granulocyte colony-stimulating factor ameliorates toxicity of intensification chemotherapy for acute lymphoblastic leukemia. (10219333)	Clarke V.... Webb D.K.	1999	CSF3
45	The effect of cytokines, including IL4, IL7, stem cell factor, insulin-like growth factor on childhood acute lymphoblastic leukemia. (9379683)	Consolini R.... Basso G.	1997	KITLG, IL7
46	Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)	Golay J.... Introna M.	1996	MYB, MYBL2, MYBL1
47	Role of granulocyte-macrophage colony-stimulating factor in Philadelphia (Ph1)-positive acute lymphoblastic leukemia: studies on two newly established Ph1-positive acute lymphoblastic leukemia cell lines (Z-119 and Z-181). (8600166)	Estrov Z.... Kurzrock R.	1996	IL3, CSF2
48	Refined mapping of genomic rearrangements involving the short arm of chromosome 9 in acute lymphoblastic leukemias and other hematologic malignancies. (7544647)	Dreyling M.H.... Olopade O.I.	1995	CDKN2A, MTAP
49	Evidence of a hypercoagulable state in patients with acute lymphoblastic leukemia treated with low dose of E. coli L-asparaginase: a GIMEMA study. (8446931)	Leone G.... Camera A.	1993	FGA
50	Use of stroma-supported cultures of leukemic cells to assess antileukemic drugs. I. Cytotoxicity of interferon alpha in acute lymphoblastic leukemia. (8255098)	Manabe A.... Campana D.	1993	IFNA1

Genes related to lymphoblastic leukemia according to GeneCards:

(show top 50)    (show all 811)

id	Symbol	Description	Score	GeneCards Section Context
1	LYL1	lymphoblastic leukemia derived sequence 1	11.1	Transcripts, Publications, Aliases & Descriptions, Orthologs (show all 5 sections) Summaries
2	TSPAN7	tetraspanin 7	11.1	Publications, Aliases & Descriptions
3	IKZF1	IKAROS family zinc finger 1 (Ikaros)	11.1	Publications, Summaries
4	FLT3	fms-related tyrosine kinase 3	11.1	Publications, Functions, Summaries
5	TCF3	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	11.1	Publications, Summaries
6	PBX1	pre-B-cell leukemia homeobox 1	11.1	Publications, Summaries
7	TLX1	T-cell leukemia homeobox 1	11.1	Publications, Summaries
8	LMO2	LIM domain only 2 (rhombotin-like 1)	11.1	Publications, Summaries
9	ABCC5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	11.1	Publications, Summaries
10	BLNK	B-cell linker	11.1	Publications, Summaries
11	PICALM	phosphatidylinositol binding clathrin assembly protein	11.1	Publications, Summaries
12	HMHB1	histocompatibility (minor) HB-1	11.1	Publications, Expressions, Functions, Summaries
13	TAL2	T-cell acute lymphocytic leukemia 2	11.1	Publications, Functions, Summaries
14	OLIG2	oligodendrocyte lineage transcription factor 2	11.1	Publications, Summaries
15	AFF4	AF4/FMR2 family, member 4	11.1	Publications, Summaries
16	ARID5B	AT rich interactive domain 5B (MRF1-like)	11.1	Publications, Summaries
17	BCL9	B-cell CLL/lymphoma 9	11.1	Summaries
18	FLI1	Friend leukemia virus integration 1	11.1	UniProt Related, Summaries
19	MLLT4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	11.1	Summaries
20	LALL	Lymphomatous acute lymphoblastic leukemia	11.1	Aliases & Descriptions
21	BLACE	B-cell acute lymphoblastic leukemia expressed	11.1	Publications, Aliases & Descriptions, Proteins
22	TPD52L2	tumor protein D52-like 2	11.0	Summaries
23	ZMIZ1	zinc finger, MIZ-type containing 1	11.0	Summaries
24	MLL	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	11.0	Publications
25	IL7	interleukin 7	11.0	Publications
26	ETV6	ets variant 6	11.0	Publications
27	TAL1	T-cell acute lymphocytic leukemia 1	11.0	Publications
28	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
29	DNTT	deoxynucleotidyltransferase, terminal	11.0	Publications
30	MTAP	methylthioadenosine phosphorylase	11.0	Publications
31	RUNX1	runt-related transcription factor 1	11.0	Publications, Functions
32	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications, Functions
33	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
34	TYMS	thymidylate synthetase	11.0	Publications
35	TRD@	T cell receptor delta locus	11.0	Publications
36	TPMT	thiopurine S-methyltransferase	11.0	Publications
37	ASNS	asparagine synthetase (glutamine-hydrolyzing)	11.0	Publications
38	HLF	hepatic leukemia factor	11.0	Publications
39	IGH@	immunoglobulin heavy locus	11.0	Publications
40	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Publications
41	THY1	Thy-1 cell surface antigen	11.0	Publications
42	FPGS	folylpolyglutamate synthase	11.0	Publications
43	GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	11.0	Publications
44	IL7R	interleukin 7 receptor	11.0	Publications
45	MVP	major vault protein	11.0	Publications
46	CD34	CD34 molecule	11.0	Publications
47	CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	11.0	Publications
48	RAG1	recombination activating gene 1	11.0	Publications
49	ANPEP	alanyl (membrane) aminopeptidase	11.0	Publications
50	BCR	breakpoint cluster region	11.0	Publications

Pathways related to lymphoblastic leukemia according to GeneDecks:

(show top 50)    (show all 302)

id	Pathway	Score	Top Affiliating Genes
1	Antioxidant Action of Vitamin-C36	19.0	KIT, KITLG, BTK, VEGFC, BMP6, RAC3
2	Pathways in cancer20	17.9	PIK3CA, PIK3CG, RELA, RB1, BRCA2, VEGFA
3	ERK Signaling36	16.9	KIT, KITLG, BTK, BRAF, VEGFC, MYC
4	Pancreatic Adenocarcinoma36	16.7	KIT, KITLG, RB1, BRAF, BRCA2, VEGFC
5	Glucocorticoid Receptor Signaling36	16.4	NCOA3, BTK, BMP6, BCL2, BAX, CEBPB
6	Jak-STAT signaling pathway20	16.2	PIK3CA, PIK3CG, MYC, BCL2L1, LEP, LEPR
7	Lymphocyte Signaling3	15.6	NCAM1, KIT, KITLG, BTK, BMI1, RAG1
8	Phospholipase-C Pathway36	15.1	KIT, KITLG, BTK, VEGFC, BMP6, RAC3
9	p70S6K Signaling36	15.0	KIT, KITLG, VEGFC, BMP6, RAC3, BDNF
10	Paxillin Interactions36	14.7	KIT, KITLG, VEGFC, BDNF, KDR, ITGA4
11	Endothelin-1 Signaling Pathway36	14.5	KIT, BTK, BRAF, MYC, BMP6, CD80
12	Tuberculosis20	14.3	RELA, VDR, BCL2, BAX, CEBPB, JAK1
13	DHA Signaling36	13.8	KIT, KITLG, VEGFC, BMP6, BDNF, KDR
14	p53 Mediated Apoptosis36	13.8	KIT, KITLG, VEGFC, BMP6, BDNF, KDR
15	Influenza A20	13.7	PIK3CA, PIK3CG, RELA, VDAC1, JUN, JAK1
16	Nanog in Mammalian ESC Pluripotency36	13.6	KIT, KITLG, BRAF, VEGFC, BMP6, BDNF
17	Immune response_IL-22 signaling pathway41	13.6	MYC, BCL2, BCL2L1, JUN, JAK1, JAK2
18	IP3 Pathway36	13.5	KITLG, BTK, VEGFC, VAV1, BMP6, BDNF
19	Nuclear Receptor Activation by Vitamin-A36	13.4	NCOA3, KIT, KITLG, VEGFC, BMP6, RARA
20	Apoptosis20	13.4	PIK3CA, PIK3CG, RELA, BIRC2, BCL2, BCL2L1
21	Rac1 Pathway36	13.4	KITLG, BMP6, PARD3, BDNF, KDR, JUN
22	IL-6 Pathway36	13.4	BTK, BRAF, BMP6, BAX, CD80, IL10
23	Immune response IL-22 signaling pathway10	13.3	MYC, BCL2, BCL2L1, JUN, JAK1, JAK2
24	all-trans-Retinoic Acid Signaling in Brain36	13.2	BTK, BMP6, RARA, RARB, BCL2, BAX
25	IL-2 Pathway36	13.2	MYC, CHUK, LCK, JUN, JAK1, FOS
26	Osteoclast differentiation20	13.1	PIK3CA, PIK3CG, RELA, BTK, LILRB1, BLNK
27	Telomerase Components in Cell Signaling36	13.1	KIT, KITLG, RB1, VEGFC, MYC, BMP6
28	Cyclins and Cell Cycle Regulation36	13.1	RB1, ATM, CDK6, CDKN1A, CDKN2C, CDK2
29	Apoptosis and survival_TNFR1 signaling pathway41	13.1	RELA, BIRC2, BCL2, CHUK, BAX, XIAP
30	Transcription_P53 signaling pathway41	13.1	RELA, RB1, VEGFA, KDR, BCL2, ATM
31	MIF Mediated Glucocorticoid Regulation36	13.1	BTK, BMP6, BCL2, BAX, CD80, MIF
32	Colorectal Cancer Metastasis36	13.1	LRP5, BRAF, MYC, BIRC5, BCL2L1, LEF1
33	eIF2 Pathway36	13.1	KIT, KITLG, BRAF, VEGFC, BMP6, BDNF
34	CREB Pathway36	13.0	KIT, KITLG, BMP6, BDNF, KDR, FLT4
35	TRAF Pathway36	13.0	BIRC2, CHUK, UBC, JUN, FOS, IL12A
36	G1-S Phase Transition36	12.9	RB1, ATM, CDK6, CDKN1A, CDKN2C, CDK2
37	Immune response BCR pathway10	12.9	PIK3CA, RELA, BTK, VAV1, BLNK, BCL2L1
38	Immune response_BCR pathway41	12.9	PIK3CA, RELA, BTK, VAV1, BLNK, BCL2L1
39	Focal adhesion20	12.8	PIK3CA, PIK3CG, VWF, BRAF, VEGFC, VAV1
40	Toll-like receptor signaling pathway20	12.6	PIK3CA, PIK3CG, RELA, CHUK, JUN, CD80
41	Immune response_IL-2 activation and signaling pathway41	12.6	PIK3CA, RELA, MYC, CHUK, LCK, JUN
42	Immune response IL-2 activation and signaling pathway10	12.4	PIK3CA, MYC, CHUK, LCK, JUN, JAK1
43	Development_PDGF signaling via STATs and NF-kB41	12.4	PIK3CA, RELA, MYC, CHUK, JAK1, JAK2
44	Transcription P53 signaling pathway10	12.0	RELA, VEGFA, CDK2, CDKN2A, APEX1, MAPK8
45	Actin-Based Motility by Rho Family GTPases36	11.9	RAC3, BDNF, ITGA4, ITGA6, ITGAL, ITGAM
46	Signal transduction PTEN pathway10	11.9	PIK3CA, PCNA, LEF1, MTOR, JUN, CDKN1A
47	Bladder cancer20	11.8	RB1, BRAF, VEGFA, VEGFC, MYC, CDKN1A
48	Colorectal cancer20	11.5	PIK3CG, BRAF, RAC3, LEF1, MSH2, MSH3
49	Immune response_MIF in innate immunity response41	11.5	RELA, CHUK, CEBPB, JUN, MIF, IL1B
50	Pancreatic cancer20	11.1	BRCA2, RAC3, CDK6

Compounds related to lymphoblastic leukemia according to GeneDecks:

(show top 50)    (show all 460)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	34.1	LRP5, SH2D4B, COG2, PDE1A, RECK, RELA
2	oxygen32 18	25.7	KITLG, SFTPD, RB1, SERPINF2, VDAC1, MYB
3	atp32	24.7	PIK3CA, RFC1, NCAM1, RECK, KIT, KIR3DL1
4	cholesterol32 9 18 9	24.5	PIK3CA, LRP5, COG2, RECK, KITLG, VWF
5	superoxide32 18	21.3	PIK3CA, KITLG, RB1, SELL, VAV1, RAN
6	creatinine32	20.0	NCAM1, KITLG, VWF, PCNA, SELL, SELP
7	adp32 18	20.0	PIK3CA, PIK3CG, RFC1, RECK, KIT, VWF
8	camptothecin32 42 9 9	21.2	PIK3CG, PCNA, RB1, NBN, BRCA2, MYC
9	estradiol32 9 18 9	20.7	NCOA3, KITLG, PCNA, RB1, SERPINE1, BRCA2
10	calcitriol32 42 9 18 9	20.9	NCOA3, KITLG, RB1, VDR, MYC, BMP6
11	daunorubicin32 9 9	18.4	RELA, KITLG, MYC, BIRC5, BCL2, BCL2L1
12	valine32	16.2	LRP5, KIT, BRAF, LPL, BDNF, MTHFR
13	iron32 18	16.8	PICALM, COG2, RECK, KITLG, VDAC1, MYCN
14	matrigel32	15.8	PIK3CA, PIK3CG, NCAM1, VWF, RB1, SERPINE1
15	glucose32	15.7	KIT, BRAF, VEGFC, RAPGEF3, PAWR, PAX4
16	nucleoside32	15.3	KITLG, BIRC5, PARK2, ZAP70, UCK2, MTAP
17	agar32	15.0	PIK3CA, KITLG, RB1, BRAF, VDAC1, MYCN
18	ascorbic acid32 18	16.0	PIK3CG, PCNA, NAT1, VDR, BGLAP, BDNF
19	troglitazone32 42 9 9	17.9	PIK3CG, RB1, SERPINE1, LPL, VDR, BMP6
20	lovastatin32 42 9 9	17.8	COG2, RB1, LPL, CHKB, XIAP, CDK6
21	histidine32	14.6	KITLG, RAD51, RARA, LGALS1, UGT1A1, MTR
22	methionine32	14.5	RECK, KIT, VWF, VDAC1, MYB, BDNF
23	ceramide32	14.3	PIK3CA, RB1, PAWR, PARK2, BCL2L1, BCL2L11
24	4-hydroxynonenal32 18	15.3	MYC, MYB, PARP1, CHUK, LCAT, BAX
25	cytochalasin d32 42	15.1	PIK3CG, KITLG, VWF, SELL, LPL, BCR
26	sodium32 18	15.0	PIK3CA, NCAM1, RECK, BRAF, BIRC5, BDNF
27	purine32 18	14.9	NCAM1, ZAP70, LBR, MTAP, MTHFR, MTR
28	1,25 dihydroxy vitamin d332	13.8	LRP5, RB1, VDR, MYC, BMP6, RARA
29	depsipeptide32	13.8	KITLG, RB1, BRAF, MYC, BCL2, BCL2L1
30	vincristine32 34 9 9	16.7	NCAM1, RECK, KIT, BTK, MYCN, BCL6
31	betacarotene32	13.3	VWF, PCNA, RB1, NAT2, LPL, RARA
32	norepinephrine32 9 18 9	16.3	KITLG, VWF, SELL, SELP, LPL, BMP6
33	ibmx32	13.3	LPL, RARB, BDNF, CDK2, CDKN3, ITGB2
34	colchicine32 9 9	15.2	PARK2, BDNF, UMOD, CHKB, ITGAL, ITGB2
35	rosiglitazone32 9 18 9	16.1	PIK3CA, PIK3CG, COG2, SERPINE1, LPL, RARB
36	nocodazole32 42 9 9	16.0	RAN, BIRC5, CLIP1, BDNF, CD79A, CDKN1A
37	ifosfamide32 9 9	14.9	B2M, GSTM1, GSTP1, GSTT1, IL11, IL3
38	isoproterenol32 9 9	14.7	SELL, BRAF, LBR, CDH5, ITGAL, ITGAM
39	c2ceramide32	12.6	PIK3CG, PARP1, BCL2L1, CHUK, UGCG, BAX
40	mifepristone32 42 9 9	15.6	BIRC5, BCL2L1, LCK, BAX, LBR, JUN
41	neopterin32	12.4	CHKB, LBR, B2M, CD79A, CD40LG, CD40
42	silymarin32	12.4	PCNA, VEGFA, BMP6, BIRC5, PARP1, CHUK
43	roscovitine32	12.3	PIK3CG, PCNA, BIRC5, PARP1, BCL2L1, XIAP
44	sulindac32 9 9	14.0	PCNA, BIRC5, BCL2, BCL2L1, BAX, XIAP
45	dextran sulfate32	11.9	SELL, SELP, SERPINC1, LPL, VDAC1, MPO
46	nadph32 18	12.6	PIK3CA, XRCC1, MAPT, HSD11B1, AKT1, CYP1A1
47	polyinosinic-polycytidylic acid32	11.5	CD40, IL10, IL12B, IL15, IL18, IL2
48	fluticasone propionate32 42 9 9	14.3	BGLAP, MPO, MMP9, IL1B, IL4, IL8
49	il-1232	11.2	CD40LG, IL10, IL12B, IL12RB1, IL15, IL18
50	zoledronic acid32	11.2	BGLAP, PAX5, PARP1, CD36, MMP9, IL2

Cellular components related to lymphoblastic leukemia according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	39.4	ZNF230, ZNF384, ZNF521, PICALM, KLF10, KLF5
2	cytoplasm	GO:005737	31.9	PIK3CG, NCOA3, RELA, KIT, KITLG, PCNA
3	plasma membrane	GO:005886	28.2	PIK3CG, LRP5, NCAM1, RECK, KIT, KITLG
4	cytosol	GO:005829	28.0	PIK3CA, PIK3CG, PDE1A, RELA, SFRP1, BTK
5	nucleolus	GO:005730	20.6	ZNF384, KLF5, NCOA3, PCNA, RBPJ, RBM39
6	nucleoplasm	GO:005654	19.8	RFC1, NCOA3, RELA, PCNA, RB1, RBPJ
7	integral to plasma membrane	GO:005887	19.3	KIR3DL1, SELL, SELP, KDR, SDC1, KCNMB2
8	extracellular region	GO:005576	18.3	NCAM1, KITLG, VWF, SFTPD, VPREB1, SERPINC1
9	extracellular space	GO:005615	17.7	KIT, KITLG, SFRP1, SFRP5, SFTPD, SELP
10	external side of plasma membrane	GO:009897	15.6	NCAM1, KIT, VWF, SELL, SELP, LILRB1
11	membrane	GO:016020	15.5	PIK3CG, RECK, CNTNAP2, VEGFA, VEGFC, VDAC1
12	membrane raft	GO:045121	12.4	BTK, BSG, UMOD, LCK, MS4A2, JAK2
13	cell surface	GO:009986	12.4	NCAM1, CNTNAP2, SFRP1, VEGFA, LPL, RARA

Biological processes related to lymphoblastic leukemia according to GeneDecks:

(show top 50)    (show all 55)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	20.7	PDE1A, CNTNAP2, KIT, KITLG, SFRP5, VEGFC
2	positive regulation of transcription from RNA polymerase II promoter	GO:045944	19.8	LRP5, NCOA3, RELA, RB1, RBPJ, SERPINF2
3	small molecule metabolic process	GO:044281	19.1	PIK3CA, PIK3CG, NCOA3, BSG, NAT1, NAT2
4	positive regulation of cell proliferation	GO:008284	17.9	LRP5, KLF5, KIT, SFRP1, NBN, VEGFA
5	apoptotic process	GO:006915	17.6	SFRP5, BTK, NBN, SEPT4, VDAC1, LMNB1
6	positive regulation of transcription, DNA-dependent	GO:045893	17.4	PICALM, LRP5, KLF5, NCOA3, RELA, SFRP1
7	blood coagulation	GO:007596	16.8	PIK3CA, PIK3CG, PDE1A, VWF, SELL, SELP
8	negative regulation of cell proliferation	GO:008285	16.7	KLF10, SFRP1, SFRP5, BTG1, VDR, RARB
9	immune response	GO:006955	16.3	KIR3DL1, VPREB1, SERPINB9, VAV1, BMP6, RAG1
10	cell proliferation	GO:008283	15.8	KLF10, KITLG, PCNA, NBN, RAPGEF3, LIG4
11	negative regulation of transcription from RNA polymerase II promoter	GO:000122	15.8	KLF10, RBPJ, VDR, LMO1, MYC, MYB
12	negative regulation of apoptotic process	GO:043066	15.6	PIK3CG, RELA, SFRP1, SERPINE1, BRAF, VEGFA
13	response to drug	GO:042493	15.5	SFRP1, NBN, VEGFC, LPL, MYC, BGLAP
14	virus-host interaction	GO:019048	15.2	RELA, RB1, VDAC1, RAN, KDR, LCK
15	negative regulation of transcription, DNA-dependent	GO:045892	14.8	RELA, SFRP1, RB1, RBPJ, SET, VDR
16	cytokine-mediated signaling pathway	GO:019221	14.8	NCAM1, RELA, KIT, UBC, MT2A, B2M
17	anti-apoptosis	GO:006916	14.7	PIK3CA, RELA, SERPINB9, BRAF, BIRC2, BIRC5
18	cell-cell signaling	GO:007267	14.1	KLF10, CEACAM6, CD33, CD70, CD80, ITGB2
19	positive regulation of apoptotic process	GO:043065	14.1	SFRP1, SEPT4, RARB, LILRB1, PAWR, BCL2L11
20	innate immune response	GO:045087	14.0	PIK3CG, RELA, SFTPD, BTK, BCL2, BCL2L1
21	cell adhesion	GO:007155	13.9	NCAM1, CNTNAP2, KITLG, VWF, SELL, SELP
22	induction of apoptosis	GO:006917	13.7	KLF10, PAWR, BCL2L11, BCL2L13, LCK, BAX
23	nerve growth factor receptor signaling pathway	GO:048011	13.7	PIK3CA, PDE1A, RELA, BRAF, VAV1, BCL2L11
24	angiogenesis	GO:001525	13.5	PIK3CA, PIK3CG, KLF5, SERPINE1, VEGFA, VEGFC
25	leukocyte migration	GO:050900	13.5	PIK3CA, SELL, SELP, BSG, LCK, CD34
26	inflammatory response	GO:006954	13.4	PIK3CG, RELA, KIT, SELP, BMP6, BLNK
27	positive regulation of gene expression	GO:010628	13.3	NCOA3, KIT, BRAF, VEGFA, VDR, LILRB1
28	response to lipopolysaccharide	GO:032496	13.1	SELP, UGT1A1, CEBPB, JUN, JAK2, MMP9
29	cell cycle arrest	GO:007050	13.1	RB1, NBN, MYC, MSH2, ATM, CDK6
30	cell surface receptor signaling pathway	GO:007166	13.1	BSG, BIRC2, LEPR, MPL, CD28, CD27
31	response to ethanol	GO:045471	13.0	BGLAP, BCL2, BAK1, CD27, CDK1, MMP9
32	platelet activation	GO:030168	13.0	PIK3CA, PIK3CG, VWF, SELP, SERPINF2, SERPINE1
33	B cell differentiation	GO:030183	12.9	RAG1, BLNK, BCL11A, BCL6, MSH2, CD79A
34	response to hypoxia	GO:001666	12.8	VEGFA, USF1, BCL2, LEP, XRCC1, ATM
35	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	12.7	MYC, BCL2L11, BCL2L13, LCK, BAX, XDH
36	induction of apoptosis by extracellular signals	GO:008624	12.7	BTK, VDR, VAV1, BCL2L11, UBC, BAK1
37	peptidyl-tyrosine phosphorylation	GO:018108	12.6	KIT, BTK, KDR, ZAP70, JAK1, JAK2
38	fibroblast growth factor receptor signaling pathway	GO:008543	12.6	PIK3CA, PDE1A, BRAF, CHUK, UBC, MTOR
39	response to organic cyclic compound	GO:014070	12.6	SFRP1, SELP, LEF1, UGT1A1, BAK1, MSH2
40	response to estradiol stimulus	GO:032355	12.6	BRCA2, VDR, RARA, MMP9, INSR, IL1B
41	epidermal growth factor receptor signaling pathway	GO:007173	12.5	PIK3CA, PDE1A, CHUK, UBC, MTOR, CDKN1B
42	regulation of immune response	GO:050776	12.5	KIR3DL1, SELL, LILRB1, BCL6, B2M, CD96
43	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	12.5	KITLG, VEGFA, MTOR, JAK2, CD36, CD81
44	positive regulation of protein phosphorylation	GO:001934	12.4	VEGFA, MTOR, CD40, FLT4, INSR, IL1B
45	induction of apoptosis by intracellular signals	GO:008629	12.3	MYC, BCL2, BCL2L1, BCL2L11, BAK1, BAX
46	G1 phase of mitotic cell cycle	GO:000080	12.3	RB1, UBC, CDK6, CDKN1A, CDKN2C, CDKN2B
47	positive regulation of MAPK cascade	GO:043410	12.2	KIT, KDR, LEP, CD36, CDH2, ITGB1
48	liver development	GO:001889	12.2	VWF, UGT1A1, CEBPA, JUN, ASNS, ARID5B
49	positive regulation of B cell proliferation	GO:030890	12.1	BCL2, BCL6, CDKN1A, CD40LG, CD40, CD38
50	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	11.5	KIT, SELP, KDR, JAK2, FLT1, FLT3

Molecular functions related to lymphoblastic leukemia according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	47.5	GGT1, GAS6, GATA2, GATA3, GAPDH, ARNT
2	sequence-specific DNA binding transcription factor activity	GO:003700	20.6	ESR1, MEF2C, ARNT, FLI1, IRF4, MLLT10
3	sequence-specific DNA binding	GO:043565	17.2	NR4A1, IKZF3, MEIS1, ARNT, FOXP1, FOXO4
4	protein homodimerization activity	GO:042803	16.4	HES1, PTGS2, TERT, TERF1, TPD52L2, HPRT1
5	protein heterodimerization activity	GO:046982	15.0	NR3C1, ITGB1, ITGAL, CEBPA, CEBPE, CEBPB
6	transcription factor binding	GO:008134	14.9	GATA2, GATA3, EP300, SMAD3, CTNNB1, SP1
7	protein kinase binding	GO:019901	14.6	SYK, TCF7L2, THY1, SKI, PFKFB2, SMAD3
8	enzyme binding	GO:019899	14.3	MSH2, UGT1A1, SCARB2, PAWR, BIRC7, BIRC5
9	transcription regulatory region DNA binding	GO:044212	12.9	TCF3, TCF12, AHR, WT1, NFKB1, SMAD3
10	growth factor activity	GO:008083	12.5	CTGF, GH1, F2, IGF1, IGF2, MDK
11	protease binding	GO:002020	12.4	CST3, BRCA2, SERPINE1, SERPINF2, SERPINB9, SERPINC1
12	cytokine activity	GO:005125	11.9	TNF, IFNG, IFNB1, IFNA2, IL7, IL6