MCID: LYM026
MIFTS: 56

Lymphoblastic Leukemia malady

Immune diseases category

Summaries for Lymphoblastic Leukemia

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MalaCards: Lymphoblastic Leukemia, also known as acute lymphocytic leukemia, is related to leukemia and acute leukemia. An important gene associated with Lymphoblastic Leukemia is TSPAN7 (tetraspanin 7), and among its related pathways are Transcriptional misregulation in cancer and Lymphocyte Signaling. The compound af 10 have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are hematopoietic system and cellular.

Aliases & Classifications for Lymphoblastic Leukemia

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60UMLS, 8Disease Ontology, 10DISEASES, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

lymphoblastic leukemia 8 10
acute lymphocytic leukemia 60


External Ids:

Disease Ontology8 DOID:1037
ICD9CM27 204.9, 204
MeSH34 D007945
NCIt39 C7539

Related Diseases for Lymphoblastic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Lymphoblastic Leukemia family:

Leukemia, Acute Lymphoblastic 2

Diseases related to Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 358)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5LYL1, TLX1, PICALM, FLT3, FLI1, BLNK
2acute leukemia32.5FLT3, PBX1, LMO2, LYL1
3myeloid leukemia31.2FLT3, PICALM
4acute myeloid leukemia31.2PICALM, FLT3
5acute lymphocytic leukemia31.1PICALM, FLT3, BLNK, IKZF1, ABCC5, PBX1
6acute lymphoblastic leukemia, childhood30.6IKZF1, FLT3, TLX1
7burkitt's lymphoma30.4TLX1, PICALM, FLT3, FLI1, BLNK, IKZF1
8precursor t-cell acute lymphoblastic leukemia30.3TLX1, PICALM, FLT3, IKZF1, LMO2, LYL1
9lymphoblastic lymphoma29.9FLI1, LMO2
10childhood leukemia11.4
11acute t cell leukemia11.3
12t-cell leukemia11.3
13adult acute lymphocytic leukemia11.1
14adult t-cell leukemia10.7
15central nervous system leukemia10.6
16adult lymphoma10.6
17chronic myeloid leukemia10.5
18hypercalcemia10.5
19down syndrome10.5
20hemophagocytic lymphohistiocytosis10.4
21sarcoma10.4
22graft versus host disease10.4
23lymphoid leukemia10.4
24osteonecrosis10.4
25breast cancer10.4
26eosinophilia10.4
27hepatitis10.4
28monocytic leukemia10.4
29neutropenia10.4
30non-hodgkin lymphoma10.4
31acute pancreatitis10.4
32acute monocytic leukemia10.4
33fusariosis10.4
34testicular leukemia10.4
35cerebritis10.4
36hyperphosphatemia10.4
37pediatric lymphoma10.4
38hodgkin's lymphoma10.4
39obesity10.4
40pancreatitis10.4
41retinitis10.4
42ataxia telangiectasia10.3
43noonan syndrome10.3
44hepatitis a10.3
45arthritis10.3
46central nervous system disease10.3
47chromosomal disease10.3
48chronic lymphocytic leukemia10.3
49influenza10.3
50nervous system disease10.3

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia:



Diseases related to lymphoblastic leukemia

Clinical Features for Lymphoblastic Leukemia

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Drugs & Therapeutics for Lymphoblastic Leukemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lymphoblastic Leukemia

Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Leukemia

Search NIH Clinical Center for Lymphoblastic Leukemia

Search CenterWatch for Lymphoblastic Leukemia

Genetic Tests for Lymphoblastic Leukemia

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Anatomical Context for Lymphoblastic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Lymphoblastic Leukemia:

32
T cells, B cells, Bone, Myeloid, Bone marrow, B lymphoblasts, Endothelial, Breast, Lung, Brain, Monocytes, Liver, Thymus, Thyroid, Spleen, Pituitary, Testes, Whole blood, Skin, Kidney, Testis, Pineal, Tonsil, Prostate, Placenta, Colon, Tongue, Spinal cord, Uterus, Temporal lobe

Animal Models for Lymphoblastic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphoblastic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.9LYL1, TLX1, ARID5B, PICALM, FLT3, FLI1
2MP:000538412.8FLI1, FLT3, PICALM, ARID5B, TLX1, BLNK
3MP:001076812.7FLI1, FLT3, MEF2D, PICALM, ARID5B, AFF4
4MP:000537812.6AFF4, FLI1, FLT3, PICALM, ARID5B, IKZF1
5MP:000538712.3TLX1, ARID5B, PICALM, FLT3, FLI1, BLNK
6MP:000200611.4FLT3, FLI1, BLNK, IKZF1, OLIG2, LMO2
7MP:000538011.2TCF3, LMO2, AFF4, TLX1

Publications for Lymphoblastic Leukemia

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50PubMed
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Articles related to Lymphoblastic Leukemia:

(show top 50)    (show all 2807)
idTitleAuthorsYear
1
Significance of CASP8AP2 and H2AFZ expression in survival and risk of relapse in children with acute lymphoblastic leukemia. (24397596)
2014
2
Clinical characteristics and treatment outcome of childhood acute lymphoblastic leukemia in Saudi Arabia: a multi-institutional retrospective national collaborative study. (23940019)
2014
3
Treating relapsed or refractory Philadelphia chromosome-negative acute lymphoblastic leukemia: liposome-encapsulated vincristine. (24072970)
2013
4
Therapy-resistant acute lymphoblastic leukemia (ALL) cells inactivate FOXO3 to escape apoptosis induction by TRAIL and Noxa. (23828551)
2013
5
Drug resistance and BCR-ABL kinase domain mutations in philadelphia chromosome-positive acute lymphoblastic leukemia from the imatinib to the second-generation tyrosine kinase inhibitor era: The main changes are in the type of mutations, but not in the frequency of mutation involvement. (24382642)
2013
6
Focal Cranial Hyperostosis From Meningioma: A Complication From Previous Radiation Treatment for Childhood T-Cell Acute Lymphoblastic Leukemia. (23459379)
2013
7
Cytomegalovirus retinitis in children and young adults with acute lymphoblastic leukemia in Lebanon. (24138305)
2013
8
Cushing's Disease Developing Independently from Acute Lymphoblastic Leukemia. (24122421)
2013
9
Chemotherapy induces enhanced procoagulant activity through phosphatidylserine exposure in acute lymphoblastic leukemia. (24074703)
2013
10
Prognostic Significance of Being Overweight and Obese at Diagnosis in Children With Acute Lymphoblastic Leukemia. (24276040)
2013
11
Demodicidosis simulating acute graft-versus-host disease after allogeneic stem cell transplantation in one patient with acute lymphoblastic leukemia. (22487272)
2012
12
IGH@ translocations, CRLF2 deregulation, and microdeletions in adolescents and adults with acute lymphoblastic leukemia. (22851563)
2012
13
Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations. (22441210)
2012
14
CD99 ligation upregulates HSP70 on acute lymphoblastic leukemia cells and concomitantly increases NK cytotoxicity. (23152061)
2012
15
Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia. (21828118)
2011
16
Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404). (21474675)
2011
17
Effect of heat shock protein-90 (HSP90) and vascular endothelial growth factor (VEGF) on survival in acute lymphoblastic leukemia: an immunohistochemical study. (20422320)
2011
18
Development of secondary T-cell acute lymphoblastic leukemia in a child with hemophagocytic lymphohistiocytosis. (20589661)
2010
19
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. (19176441)
2009
20
Changes in acetylcholinesterase (AchE) activity in lymphocytes and whole blood in acute lymphoblastic leukemia patients. (19185568)
2009
21
The MTHFR polymorphism C677T in adult patients with acute lymphoblastic leukemia is associated with an increased prevalence of cytogenetic abnormalities. (17962051)
2008
22
Troglitazone inhibits cell growth and induces apoptosis of B-cell acute lymphoblastic leukemia cells with t(14;18). (16809887)
2006
23
The impact of acute and chronic graft-versus-host disease on normal and malignant B-lymphoid precursors after allogeneic stem cell transplantation for B-lineage acute lymphoblastic leukemia. (16531257)
2006
24
Level of tau protein in children treated for acute lymphoblastic leukemia. (16647996)
2006
25
Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia. (15718422)
2005
26
ZAP-70 tyrosine kinase is constitutively expressed and phosphorylated in B-lineage acute lymphoblastic leukemia cells. (15996927)
2005
27
Successful treatment of hypereosinophilic syndrome after remission of acute lymphoblastic leukemia in a patient who underwent non-myeloablative stem cell transplantation. (15075099)
2004
28
Iron overload in children who are treated for acute lymphoblastic leukemia estimated by liver siderosis and serum iron parameters. (12509560)
2003
29
Liver histology after current intensified therapy for childhood acute lymphoblastic leukemia: microvesicular fatty change and siderosis are the main findings. (12518342)
2003
30
Incidence, clinical characteristics and early treatment outcome in Indian patients of childhood acute lymphoblastic leukemia with ALL-1 gene rearrangement. (11397475)
2001
31
Increased expression of lung resistance-related protein and multidrug resistance-associated protein messenger RNA in childhood acute lymphoblastic leukemia. (10695821)
2000
32
Effects of cranial radiation in children with high risk T cell acute lymphoblastic leukemia: a Pediatric Oncology Group report. (10720128)
2000
33
Granular acute lymphoblastic leukemia with hypereosinophilic syndrome. (10870483)
2000
34
Relationship between the intracellular daunorubicin concentration, expression of major vault protein/lung resistance protein and resistance to anthracyclines in childhood acute lymphoblastic leukemia. (10602424)
1999
35
Intensive short term therapy with granulocyte-macrophage-colony stimulating factor support, similar to therapy for acute myeloblastic leukemia, does not improve overall results for adults with acute lymphoblastic leukemia. GOELAMS Group. (10526278)
1999
36
Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: relationship to immunophenotype and ploidy. (9748136)
1998
37
Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia. European Organization for Research and Treatment of Cancer--Childhood Leukemia Cooperative Group. (9718378)
1998
38
Unilateral laterothoracic exanthem in a child with acute lymphoblastic leukemia. (9496806)
1998
39
Use of cytokines in the treatment of acute lymphoblastic leukemia. (9179281)
1997
40
Methylation of the multi tumor suppressor gene-2 (MTS2, CDKN1, p15INK4B) in childhood acute lymphoblastic leukemia. (9399648)
1997
41
Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia. (9060559)
1997
42
Biological and clinical significance of cytogenetic study on 100 acute lymphoblastic leukemia and 219 acute non-lymphoblastic leukemia. (9594276)
1997
43
Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements. (8562939)
1996
44
A randomized phase-III study of the efficacy of granulocyte colony-stimulating factor in children with high-risk acute lymphoblastic leukemia. Berlin-Frankfurt-MA1nster Study Group. (8605328)
1996
45
Acute bilateral parotitis during chemotherapy for acute lymphoblastic leukemia. (1384258)
1992
46
Cranial nerve palsy in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma. (2013032)
1991
47
Impaired expression of interleukin 2 receptors in childhood acute lymphoblastic leukemia. (1861542)
1991
48
Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin. (1909409)
1991
49
Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. (2521388)
1989
50
Selective use of daunorubicin for remission-induction chemotherapy in acute non-lymphoblastic leukemia. (6932996)
1980

Genetic Variations for Lymphoblastic Leukemia

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Expression for genes affiliated with Lymphoblastic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoblastic Leukemia

Search GEO for disease gene expression data for Lymphoblastic Leukemia.

Pathways for genes affiliated with Lymphoblastic Leukemia

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29KEGG, 4Cell Signaling Technology, 53Reactome
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Pathways related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9LYL1, TLX1, FLT3, FLI1, PBX1, LMO2
211.3FLI1, BLNK, IKZF1, PBX1, TCF3
3
Hide members
10.8TCF3, MEF2D

Compounds for genes affiliated with Lymphoblastic Leukemia

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44Novoseek
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Compounds related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1af 104410.8PICALM, TLX1

GO Terms for genes affiliated with Lymphoblastic Leukemia

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16Gene Ontology
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Cellular components related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.7LYL1, ARID5B, PICALM, MEF2D, FLI1, AFF4

Biological processes related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594411.7TLX1, MEF2D, IKZF1, LMO2, TCF3, BCL9
2B cell differentiationGO:03018311.5LYL1, TCF3, IKZF1, BLNK, FLT3
3Peyers patch developmentGO:04854111.0IKZF1, TCF3
4thalamus developmentGO:02179410.9OLIG2, TAL2
5cell developmentGO:04846810.9ARID5B, TCF3
6natural killer cell differentiationGO:00177910.8IKZF1, TCF3
7spleen developmentGO:04853610.8PBX1, TLX1
8embryonic hemopoiesisGO:03516210.7LMO2, PBX1
9adrenal gland developmentGO:03032510.5PBX1, ARID5B

Molecular functions related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.8FLT3, MEF2D, PICALM, ARID5B, TLX1, AFF4
2DNA bindingGO:00367712.0ARID5B, FLI1, IKZF1, TAL2, OLIG2, PBX1
3sequence-specific DNA binding transcription factor activityGO:00370011.9TCF3, TLX1, MEF2D, FLI1, AFF4, IKZF1
4protein heterodimerization activityGO:04698211.2TLX1, IKZF1, PBX1, TCF3
5protein dimerization activityGO:04698310.9LYL1, TAL2, MEF2D
6bHLH transcription factor bindingGO:04342510.9TCF3, LMO2
7E-box bindingGO:07088810.8TCF3, LMO2
8RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.5LMO2, MEF2D

Products for genes affiliated with Lymphoblastic Leukemia

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Sources for Lymphoblastic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet