MCID: LYM026
MIFTS: 56

Lymphoblastic Leukemia malady

Immune diseases category

Summaries for Lymphoblastic Leukemia

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MalaCards: Lymphoblastic Leukemia, also known as acute lymphocytic leukemia, is related to leukemia and acute leukemia. An important gene associated with Lymphoblastic Leukemia is TSPAN7 (tetraspanin 7), and among its related pathways are Transcriptional misregulation in cancer and Lymphocyte Signaling. The compound af 10 have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are hematopoietic system and cellular.

Aliases & Classifications for Lymphoblastic Leukemia

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60UMLS, 8Disease Ontology, 10DISEASES, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

lymphoblastic leukemia 8 10
acute lymphocytic leukemia 60


External Ids:

Disease Ontology8 DOID:1037
ICD9CM27 204.9, 204
MeSH34 D007945
NCIt39 C7539

Related Diseases for Lymphoblastic Leukemia

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17GeneCards, 18GeneDecks
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Diseases in the Lymphoblastic Leukemia family:

Leukemia, Acute Lymphoblastic 2

Diseases related to Lymphoblastic Leukemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 358)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia32.5LYL1, TLX1, PICALM, FLT3, FLI1, BLNK
2acute leukemia32.5FLT3, PBX1, LMO2, LYL1
3myeloid leukemia31.2FLT3, PICALM
4acute myeloid leukemia31.2PICALM, FLT3
5acute lymphocytic leukemia31.1PICALM, FLT3, BLNK, IKZF1, ABCC5, PBX1
6acute lymphoblastic leukemia, childhood30.6IKZF1, FLT3, TLX1
7burkitt's lymphoma30.4TLX1, PICALM, FLT3, FLI1, BLNK, IKZF1
8precursor t-cell acute lymphoblastic leukemia30.3TLX1, PICALM, FLT3, IKZF1, LMO2, LYL1
9lymphoblastic lymphoma29.9FLI1, LMO2
10childhood leukemia11.4
11acute t cell leukemia11.3
12t-cell leukemia11.3
13adult acute lymphocytic leukemia11.1
14adult t-cell leukemia10.7
15central nervous system leukemia10.6
16adult lymphoma10.6
17chronic myeloid leukemia10.5
18hypercalcemia10.5
19down syndrome10.5
20hemophagocytic lymphohistiocytosis10.4
21sarcoma10.4
22graft versus host disease10.4
23lymphoid leukemia10.4
24osteonecrosis10.4
25breast cancer10.4
26eosinophilia10.4
27hepatitis10.4
28monocytic leukemia10.4
29neutropenia10.4
30non-hodgkin lymphoma10.4
31acute pancreatitis10.4
32acute monocytic leukemia10.4
33fusariosis10.4
34testicular leukemia10.4
35cerebritis10.4
36hyperphosphatemia10.4
37pediatric lymphoma10.4
38hodgkin's lymphoma10.4
39obesity10.4
40pancreatitis10.4
41retinitis10.4
42ataxia telangiectasia10.3
43noonan syndrome10.3
44hepatitis a10.3
45arthritis10.3
46central nervous system disease10.3
47chromosomal disease10.3
48chronic lymphocytic leukemia10.3
49influenza10.3
50nervous system disease10.3

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia:



Diseases related to lymphoblastic leukemia

Clinical Features for Lymphoblastic Leukemia

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Drugs & Therapeutics for Lymphoblastic Leukemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lymphoblastic Leukemia

Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Leukemia

Search NIH Clinical Center for Lymphoblastic Leukemia

Search CenterWatch for Lymphoblastic Leukemia

Genetic Tests for Lymphoblastic Leukemia

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Anatomical Context for Lymphoblastic Leukemia

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32MalaCards
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MalaCards organs/tissues related to Lymphoblastic Leukemia:

32
T cells, B cells, Bone, Myeloid, Bone marrow, B lymphoblasts, Endothelial, Breast, Lung, Brain, Monocytes, Liver, Thymus, Thyroid, Spleen, Pituitary, Testes, Whole blood, Skin, Kidney, Testis, Pineal, Tonsil, Prostate, Placenta, Colon, Tongue, Spinal cord, Uterus, Temporal lobe

Animal Models for Lymphoblastic Leukemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphoblastic Leukemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539712.9LYL1, TLX1, ARID5B, PICALM, FLT3, FLI1
2MP:000538412.8FLI1, FLT3, PICALM, ARID5B, TLX1, BLNK
3MP:001076812.7FLI1, FLT3, MEF2D, PICALM, ARID5B, AFF4
4MP:000537812.6AFF4, FLI1, FLT3, PICALM, ARID5B, IKZF1
5MP:000538712.3TLX1, ARID5B, PICALM, FLT3, FLI1, BLNK
6MP:000200611.4FLT3, FLI1, BLNK, IKZF1, OLIG2, LMO2
7MP:000538011.2TCF3, LMO2, AFF4, TLX1

Publications for Lymphoblastic Leukemia

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50PubMed
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Articles related to Lymphoblastic Leukemia:

(show top 50)    (show all 2807)
idTitleAuthorsYear
1
Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group. (24222333)
2014
2
High CXCR4 and low VLA-4 expression predicts poor survival in adults with acute lymphoblastic leukemia. (24239175)
2014
3
Fetal growth and childhood acute lymphoblastic leukemia: findings from the childhood leukemia international consortium. (23754574)
2013
4
Epigenetic inactivation of Notch-Hes pathway in human B-cell acute lymphoblastic leukemia. (23637910)
2013
5
Convergence of the ZMIZ1 and NOTCH1 pathways at C-MYC in acute T lymphoblastic leukemias. (23161489)
2013
6
Measuring vincristine-induced peripheral neuropathy in children with acute lymphoblastic leukemia. (23842524)
2013
7
Vincristine sulfate liposomal injection for acute lymphoblastic leukemia. (24232122)
2013
8
Src kinase-induced phosphorylation of annexin A2 mediates glucocorticoid resistance in MLL-rearranged infant acute lymphoblastic leukemia. (23334362)
2013
9
Recent advances in acute lymphoblastic leukemia in children and adolescents: an expert panel discussion. (24305505)
2013
10
Impact of mutations in FLT3, PTPN11, and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil. (24067137)
2013
11
O-acetylated N-acetylneuraminic acid as a novel target for therapy in human pre-B acute lymphoblastic leukemia. (23478187)
2013
12
Increase Expression of Co-stimulatory molecules (CD86 and sCTLA-4) in Patients with Acute Lymphoblastic Leukemia. (24283754)
2013
13
A disseminated infection with the antifungal-multiresistant teleomorphic fungus Neocosmospora vasinfecta in a patient with acute B-lymphoblastic leukemia. (24432214)
2013
14
Expression of the promyelocytic leukemia zinc-finger in T-lymphoblastic lymphoma and leukemia has strong implications for their cellular origin and greater association with initial bone marrow involvement. (22555178)
2012
15
Successful alternative treatment containing vindesine for acute lymphoblastic leukemia with Charcot-Marie-Tooth disease. (22246157)
2012
16
BCR-ABL Translocation in Pediatric Acute Lymphoblastic Leukemia in Southern India. (23449388)
2012
17
Hemophagocytic lymphohistiocytosis associated with precursor B acute lymphoblastic leukemia. (21298755)
2011
18
T-cell lymphoblastic lymphoma shows differences and similarities with T-cell acute lymphoblastic leukemia by genomic and gene expression analyses. (21987448)
2011
19
Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia. (19631983)
2010
20
NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols. (20861909)
2010
21
14q32/miRNA clusters loss of heterozygosity in acute lymphoblastic leukemia is associated with up-regulation of BCL11a. (20578197)
2010
22
Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. (20139093)
2010
23
ETV6-ARNT fusion in a patient with childhood T lymphoblastic leukemia. (20804916)
2010
24
Promoter polymorphisms in the I^-2 adrenergic receptor are associated with drug-induced gene expression changes and response in acute lymphoblastic leukemia. (20981007)
2010
25
Outcome of patients treated for relapsed or refractory acute lymphoblastic leukemia: a Therapeutic Advances in Childhood Leukemia Consortium study. (19841326)
2010
26
Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells. (19054556)
2009
27
5,10-Methylenetetrahydrofolate reductase (MTHFR) low activity genotypes reduce the risk of relapse-related acute lymphoblastic leukemia (ALL). (19178944)
2009
28
Overexpression of CD49f in precursor B-cell acute lymphoblastic leukemia: potential usefulness in minimal residual disease detection. (18831072)
2009
29
The difference between pre-B cell acute lymphoblastic leukemia and Burkitt lymphoma in relation to DNA damage repair gene polymorphisms in childhood. (18608862)
2008
30
Synergistic effect of methyltetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphism as risk modifiers of pediatric acute lymphoblastic leukemia. (19034339)
2007
31
Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma and acute biphenotypic leukemias. (17369128)
2007
32
Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe. (16886902)
2006
33
Presence of somatic hypermutation and activation-induced cytidine deaminase in acute lymphoblastic leukemia L2 with t(14;18)(q32;q21). (15613101)
2005
34
Development of cold agglutinin autoimmune hemolytic anemia during treatment for pediatric acute lymphoblastic leukemia. (16012332)
2005
35
Ureteral obstruction caused by L-asparaginase-induced pancreatitis in a child with acute lymphoblastic leukemia. (15216406)
2004
36
Loss of imprinting of IGF-II gene in children with acute lymphoblastic leukemia. (12804639)
2003
37
Jak3 expression and genomic sequence in pediatric acute lymphoblastic leukemia. (12613524)
2002
38
LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia. (12203795)
2002
39
Hemizygous p16(INK4A) deletion in pediatric acute lymphoblastic leukemia predicts independent risk of relapse. (11154239)
2001
40
Regeneration pattern of precursor-B-cells in bone marrow of acute lymphoblastic leukemia patients depends on the type of preceding chemotherapy. (10764156)
2000
41
Application of germline IGH probes in real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia. (10942239)
2000
42
Ig heavy chain gene rearrangements in T-cell acute lymphoblastic leukemia exhibit predominant DH6-19 and DH7-27 gene usage, can result in complete V-D-J rearrangements, and are rare in T-cell receptor alpha beta lineage. (10361104)
1999
43
Discrimination of leukoencephalopathy from leukemic cell invasion by MR spectroscopy in a patient with acute lymphoblastic leukemia]. (10355139)
1999
44
Phenotypic conversion from t(8;21) acute myeloid leukemia to MLL gene rearrangement-positive acute lymphoblastic leukemia. (9844825)
1998
45
Differential CD95 expression and function in T and B lineage acute lymphoblastic leukemia cells. (9264377)
1997
46
Molecular epidemiology of acute lymphoblastic leukemia in Egypt. (7845017)
1995
47
Phorbol myristate acetate-induced expression of high-affinity interleukin 2 receptors and production of interleukin 2 by human acute lymphoblastic leukemia T cells. (1588792)
1992
48
Multidrug resistance (MDR) gene expression in acute non lymphoblastic leukemia: sequential analysis. (1363283)
1992
49
Acute non-lymphoblastic leukemia in children: prognostic factors and results of chemotherapy. (2361737)
1990
50
The labelling index of marrow myeloblasts: a predictive test for relapse of acute non-lymphoblastic leukemia. (6931957)
1980

Genetic Variations for Lymphoblastic Leukemia

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Expression for genes affiliated with Lymphoblastic Leukemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoblastic Leukemia

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Pathways for genes affiliated with Lymphoblastic Leukemia

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29KEGG, 4Cell Signaling Technology, 53Reactome
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Pathways related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.9LYL1, TLX1, FLT3, FLI1, PBX1, LMO2
211.3FLI1, BLNK, IKZF1, PBX1, TCF3
3
Hide members
10.8TCF3, MEF2D

Compounds for genes affiliated with Lymphoblastic Leukemia

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44Novoseek
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Compounds related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1af 104410.8PICALM, TLX1

GO Terms for genes affiliated with Lymphoblastic Leukemia

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16Gene Ontology
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Cellular components related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563412.7LYL1, ARID5B, PICALM, MEF2D, FLI1, AFF4

Biological processes related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:04594411.7TLX1, MEF2D, IKZF1, LMO2, TCF3, BCL9
2B cell differentiationGO:03018311.5LYL1, TCF3, IKZF1, BLNK, FLT3
3Peyers patch developmentGO:04854111.0IKZF1, TCF3
4thalamus developmentGO:02179410.9OLIG2, TAL2
5cell developmentGO:04846810.9ARID5B, TCF3
6natural killer cell differentiationGO:00177910.8IKZF1, TCF3
7spleen developmentGO:04853610.8PBX1, TLX1
8embryonic hemopoiesisGO:03516210.7LMO2, PBX1
9adrenal gland developmentGO:03032510.5PBX1, ARID5B

Molecular functions related to Lymphoblastic Leukemia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551512.8FLT3, MEF2D, PICALM, ARID5B, TLX1, AFF4
2DNA bindingGO:00367712.0ARID5B, FLI1, IKZF1, TAL2, OLIG2, PBX1
3sequence-specific DNA binding transcription factor activityGO:00370011.9TCF3, TLX1, MEF2D, FLI1, AFF4, IKZF1
4protein heterodimerization activityGO:04698211.2TLX1, IKZF1, PBX1, TCF3
5protein dimerization activityGO:04698310.9LYL1, TAL2, MEF2D
6bHLH transcription factor bindingGO:04342510.9TCF3, LMO2
7E-box bindingGO:07088810.8TCF3, LMO2
8RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.5LMO2, MEF2D

Products for genes affiliated with Lymphoblastic Leukemia

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Sources for Lymphoblastic Leukemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet