MCID: LYM026
MIFTS: 66

Lymphoblastic Leukemia

Categories: Cancer diseases, Rare diseases, Blood diseases, Genetic diseases, Immune diseases

Aliases & Classifications for Lymphoblastic Leukemia

MalaCards integrated aliases for Lymphoblastic Leukemia:

Name: Lymphoblastic Leukemia 12 14
Precursor Cell Lymphoblastic Leukemia Lymphoma 69
Acute Lymphocytic Leukemia 69
Leukemia, Lymphoid 41
Lymphoid Leukemia 69

Classifications:



External Ids:

Disease Ontology 12 DOID:1037
ICD10 32 C91 C91.9 C91.90
ICD9CM 34 204 204.9
MeSH 41 D007945
NCIt 46 C7539

Summaries for Lymphoblastic Leukemia

Disease Ontology : 12 A leukemia that has material basis in lymphoblasts (immature white blood cells).

MalaCards based summary : Lymphoblastic Leukemia, also known as precursor cell lymphoblastic leukemia lymphoma, is related to b-cell childhood acute lymphoblastic leukemia and acute lymphoblastic leukemia, childhood, and has symptoms including edema, chest pain and angina pectoris. An important gene associated with Lymphoblastic Leukemia is FLT3 (Fms Related Tyrosine Kinase 3), and among its related pathways/superpathways are Pathways in cancer and NF-kappaB Signaling. The drugs Arranon and Blincyto have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are Decreased viability in esophageal squamous lineage and cellular

Related Diseases for Lymphoblastic Leukemia

Diseases in the Lymphoblastic Leukemia family:

Leukemia, Acute Lymphoblastic Leukemia, Acute Lymphoblastic 2
Leukemia, Acute Lymphoblastic 3

Diseases related to Lymphoblastic Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 475)
# Related Disease Score Top Affiliating Genes
1 b-cell childhood acute lymphoblastic leukemia 34.4 IKZF1 RUNX1
2 acute lymphoblastic leukemia, childhood 34.3 ETV6 FLT3 RUNX1
3 precursor t-cell acute lymphoblastic leukemia 33.4 ABL1 BAX ETV6 FLT3 IKZF1 LMO2
4 leukemia, acute lymphoblastic 33.4 ABL1 AFF1 BAX ETV6 FLT3 NBN
5 acute lymphocytic leukemia 33.2 ETV6 NBN NOTCH1 PAX5 RUNX1 TAL2
6 b-cell adult acute lymphocytic leukemia 33.1 ABL1 IKZF1 PAX5 PBX1
7 leukemia, acute myeloid 32.6 ABL1 AFF1 ETV6 FLT3 RUNX1
8 leukemia, acute lymphoblastic 3 32.5 ABL1 AFF1 ETV6 FLT3 IKZF1 PAX5
9 lymphoid leukemia 32.3 ETV6 RUNX1
10 leukemia 32.1 ABL1 BAX ETV6 FLT3 LYL1 PBX1
11 myeloid leukemia 31.1 ABL1 ETV6 FLT3 RUNX1
12 childhood leukemia 31.0 ABL1 ETV6 PBX1 RUNX1 TCF3
13 leukemia, chronic myeloid 30.9 ABL1 ETV6 FLT3 RUNX1
14 acute leukemia 30.9 AFF1 ETV6 FLT3 PAX5 RUNX1 TCF3
15 chronic myelomonocytic leukemia 30.6 ETV6 FLT3 RUNX1
16 myelodysplastic syndrome 30.6 ABL1 ETV6 FLT3 RUNX1
17 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.3 ETV6 FLT3 RUNX1
18 t-cell leukemia 29.8 LMO2 NOTCH1 TLX1
19 lymphoblastic leukemia, acute, with lymphomatous features 12.2
20 acute non lymphoblastic leukemia 12.2
21 acute lymphoblastic leukemia congenital sporadic aniridia 12.0
22 lymphoblastic lymphoma 11.9
23 precursor lymphoblastic lymphoma/leukemia 11.7
24 t-cell childhood acute lymphocytic leukemia 11.6
25 bone marrow necrosis 11.4
26 leukemia, chronic lymphocytic 11.4
27 precursor b lymphoblastic lymphoma/leukemia 11.4
28 acute t cell leukemia 11.3
29 t-cell adult acute lymphocytic leukemia 11.2
30 null-cell leukemia 11.2
31 medulloblastoma 11.0
32 precursor t-lymphoblastic lymphoma/leukemia 11.0
33 childhood precursor t-lymphoblastic lymphoma/leukemia 11.0
34 lymphoma 10.7
35 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.6 FLT3 RUNX1
36 platelet disorder, familial, with associated myeloid malignancy 10.6 ETV6 RUNX1
37 mn1 10.5 ETV6 FLT3
38 bone marrow cancer 10.5 ABL1 ETV6 FLT3 RUNX1
39 glucocorticoid resistance, generalized 10.3
40 prostate cancer 10.3
41 hematopoietic stem cell transplantation 10.3
42 hematologic cancer 10.2 ABL1 ETV6 FLT3 IKZF1 NOTCH1 PAX5
43 aging 10.2
44 hypercalcemia, infantile, 1 10.2
45 sarcoma 10.2
46 down syndrome 10.1
47 hereditary wilms' tumor 10.1
48 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 10.1
49 wilms tumor 6 10.1
50 osteonecrosis 10.1

Comorbidity relations with Lymphoblastic Leukemia via Phenotypic Disease Network (PDN):


Deficiency Anemia Leukemia, Chronic Lymphocytic
Neutropenia

Graphical network of the top 20 diseases related to Lymphoblastic Leukemia:



Diseases related to Lymphoblastic Leukemia

Symptoms & Phenotypes for Lymphoblastic Leukemia

UMLS symptoms related to Lymphoblastic Leukemia:


edema, chest pain, angina pectoris

GenomeRNAi Phenotypes related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.32 ABL1 AFF1 AFF4 BCL9 FLT3 LMO2

MGI Mouse Phenotypes related to Lymphoblastic Leukemia:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 ABL1 AFF4 BAX ETV6 FLT3 IKZF1
2 hematopoietic system MP:0005397 10.39 ABL1 AFF1 AFF4 BAX ETV6 FLT3
3 growth/size/body region MP:0005378 10.38 ABL1 AFF1 AFF4 BAX ETV6 FLT3
4 immune system MP:0005387 10.31 RUNX1 TCF3 TLX1 PAX5 PBX1 ABL1
5 endocrine/exocrine gland MP:0005379 10.27 ABL1 AFF1 AFF4 BAX ETV6 FLT3
6 mortality/aging MP:0010768 10.27 RUNX1 TAL2 TCF3 ABL1 AFF1 AFF4
7 behavior/neurological MP:0005386 10.24 OLIG2 PAX5 PBX1 RUNX1 TAL2 ABL1
8 embryo MP:0005380 10.21 ABL1 AFF4 ETV6 LMO2 NBN NOTCH1
9 nervous system MP:0003631 10.07 ABL1 AFF1 BAX LMO2 NBN NOTCH1
10 neoplasm MP:0002006 10.06 RUNX1 TCF3 BAX ETV6 FLT3 IKZF1
11 liver/biliary system MP:0005370 9.95 ABL1 IKZF1 LMO2 NOTCH1 PBX1 RUNX1
12 no phenotypic analysis MP:0003012 9.7 AFF1 ETV6 FLT3 IKZF1 OLIG2 RUNX1
13 respiratory system MP:0005388 9.56 RUNX1 ABL1 AFF4 BAX IKZF1 NOTCH1
14 skeleton MP:0005390 9.28 ABL1 BAX FLT3 LMO2 NOTCH1 OLIG2

Drugs & Therapeutics for Lymphoblastic Leukemia

FDA approved drugs:

(show all 7)
# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Arranon 17 45 NELARABINE GlaxoSmithKline October 2005
2
Blincyto 17 45 BLINATUMOMAB Amgen December 2014
3
Clolar 17 45 CLOFARABINE Genzyme December, 2004
4
Erwinaze 17 45 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
5
Iclusig 17 45 PONATINIB HYDROCHLORIDE Ariad Pharmaceuticals December 2012
6
Marqibo 17 45 VINCRISTINE SULFATE Talon Therapeutics August 2012
7
Sprycel 17 45 DASATINIB Bristol-Myers Squibb June 2006

Drugs for Lymphoblastic Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 689)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
3
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
5
Asparaginase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
6
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 147-94-4 6253
7
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
8
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
9
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2068-78-2, 57-22-7 5978
10
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
11
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 23214-92-8 31703
12
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
13
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
16
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
17
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 4291-63-8 20279
18
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
19
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751
20
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
21
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
22
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2 53643-48-4, 59917-39-4 40839
23
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
24
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53910-25-1 439693 40926
25
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
26
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 657311 5754
27
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
28
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
29
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24356-66-9 21704 32326
30 Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
31
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
33
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
34
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
35
Methylphenidate Approved, Investigational Phase 4 20748-11-2, 113-45-1 4158
36
Oprelvekin Approved, Investigational Phase 4 145941-26-0
37
Menthol Approved Phase 4 2216-51-5 16666
38
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
39
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
40
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
41
Nicotine Approved Phase 4 54-11-5 89594 942
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
43
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
44
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Early Phase 1 67-97-0 10883523 5280795 6221
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 1406-16-2
46
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 50-14-6 5280793
47
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 31703
48
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
49
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
50 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 2673)

# Name Status NCT ID Phase Drugs
1 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
2 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
3 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
4 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
5 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
6 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
7 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
8 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
9 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
10 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
11 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
12 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
13 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
14 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
15 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
16 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
17 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
18 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
19 Observational Study in Participants With Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM) and Non-Hodgkin's Lymphoma (NHL) in Latin America Completed NCT02559583 Phase 4
20 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]
21 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
22 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
23 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4 Valganciclovir
24 A Study of Rituximab in Combination With Fludarabine and Cyclophosphamide in Participants With Chronic Lymphocytic Leukemia and Favorable Somatic Status Completed NCT01271010 Phase 4 Cyclophosphamide;Fludarabine;Rituximab
25 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
26 A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status Completed NCT01283386 Phase 4 chlorambucil;cyclophosphamide;fludarabine;rituximab [MabThera]
27 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
28 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
29 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
30 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4 Ofatumumab
31 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
32 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
33 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
34 Effect of Epoetin Alfa on Hemoglobin, Symptom Distress, and Quality of Life in Patients Receiving Chemotherapy Completed NCT00524407 Phase 4 Epoetin alfa
35 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
36 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
37 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
38 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
39 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
40 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
41 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
42 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
43 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
44 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
45 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
46 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
47 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
48 Low Grade Lymphoma Recruiting NCT01698866 Phase 4
49 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
50 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate

Search NIH Clinical Center for Lymphoblastic Leukemia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: leukemia, lymphoid

Genetic Tests for Lymphoblastic Leukemia

Anatomical Context for Lymphoblastic Leukemia

MalaCards organs/tissues related to Lymphoblastic Leukemia:

38
B Cells, T Cells, Bone, Bone Marrow, Myeloid, Kidney, Nk Cells

Publications for Lymphoblastic Leukemia

Articles related to Lymphoblastic Leukemia:

(show top 50) (show all 3469)
# Title Authors Year
1
<i>PDGFRB</i> mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia. ( 29434033 )
2018
2
Immunosuppressive monocytes (CD14<sup>+</sup>/HLA-DR<sup>low/-</sup>) increase in childhood precursor B-cell acute lymphoblastic leukemia after induction chemotherapy. ( 29429058 )
2018
3
Sphingosine kinase 2 supports the development of BCR/ABL-independent acute lymphoblastic leukemia in mice. ( 29441205 )
2018
4
Outcome of pediatric patients with acute lymphoblastic leukemia/lymphoblastic lymphoma with hypersensitivity to pegaspargase treated with PEGylated Erwinia asparaginase, pegcrisantaspase: A report from the Children's Oncology Group. ( 29090524 )
2018
5
Hyper-CVAD plus nelarabine in newly diagnosed adult T-cell acute lymphoblastic leukemia and T-lymphoblastic lymphoma. ( 29047158 )
2018
6
Flow cytometric characterization of acute leukemia reveals a distinctive "blast gate" of murine T-lymphoblastic leukemia/lymphoma. ( 29416774 )
2018
7
Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21. ( 29449437 )
2018
8
MicroRNA expression and activity in T-cell acute lymphoblastic leukemia. ( 29435192 )
2018
9
A strategy for the clinical remission of acute lymphoblastic leukemia elicited by treatment of I^-thalassemia major: A case report. ( 29435306 )
2018
10
Long non-coding RNA PAX8-AS1 polymorphisms increase the risk of childhood acute lymphoblastic leukemia. ( 29435279 )
2018
11
Anti-leukemic treatment-induced neurotoxicity in long-term survivors of childhood acute lymphoblastic leukemia: impact of reduced central nervous system radiotherapy and intermediate- to high-dose methotrexate. ( 29424258 )
2018
12
A case of B-cell precursor acute lymphoblastic leukemia with IL3-IGH rearrangement revealed by thromboembolism and marked eosinophilia. ( 29424254 )
2018
13
Erratum: Cooperation of IRAK1/4 inhibitor and ABT-737 in nanoparticles for synergistic therapy of T cell acute lymphoblastic leukemia [Corrigendum]. ( 29443320 )
2018
14
Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B-precursor acute lymphoblastic leukemia. ( 28853218 )
2018
15
Cyclin dependent kinase inhibitor 2A/B gene deletions are markers of poor prognosis in Indian children with acute lymphoblastic leukemia. ( 29446543 )
2018
16
Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group. ( 29360413 )
2018
17
T-Lymphoblastic Leukemia/Lymphoma With Annular Skin Rash and Epidermotropism. ( 29443697 )
2018
18
Transformation of Chronic Lymphocytic Leukemia (CLL) into B-cell Acute Lymphoblastic Leukemia (ALL). ( 29437555 )
2018
19
A rare e14a3 BCR/ABL fusion transcript in acute lymphoblastic leukemia patient treated with CAR-modified T-cell therapy. ( 29434963 )
2018
20
Pediatric-Inspired Treatment Regimens for Adolescents and Young Adults With Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia: A Review. ( 29450465 )
2018
21
Both left ventricular papillary muscles necrosis, an eosinophylic lymphoblastic leukemia revealed by endomyocardial fibrosis. ( 29366603 )
2018
22
Recent Developments in Adolescent and Young Adult (AYA) Acute Lymphoblastic Leukemia. ( 29442287 )
2018
23
Acute lymphoblastic leukemia and lymphoblastic lymphoma in adolescents and young adults. ( 29418064 )
2018
24
MSH6 haploinsufficiency at relapse contributes to the development of thiopurine resistance in pediatric B-lymphoblastic leukemia. ( 29449434 )
2018
25
Successful Combination Therapy of Liposomal Amphotericin B and Caspofungin for Disseminated Fusariosis in a Pediatric Patient with Acute Lymphoblastic Leukemia. ( 29438132 )
2018
26
Lymphomatoid Granulomatosis in a 14-Year-Old Boy with Trisomy 21 and History of B-Lymphoblastic Leukemia/Lymphoma. ( 29336635 )
2018
27
CREB knockdown inhibits growth and induces apoptosis in human pre-B acute lymphoblastic leukemia cells through inhibition of prosurvival signals. ( 28063408 )
2017
28
Treatment of unilateral zone I cytomegalovirus retinitis in acute lymphoblastic leukemia with oral valganciclovir and intravitreal ganciclovir. ( 29118508 )
2017
29
The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia. ( 29023469 )
2017
30
T-cell acute lymphoblastic leukemia in infants has distinct genetic and epigenetic features compared to childhood cases. ( 27717083 )
2017
31
Dihydrofolate Reductase Genetic Polymorphisms Affect Methotrexate Dose Requirements in Pediatric Patients With Acute Lymphoblastic Leukemia on Maintenance Therapy. ( 28719513 )
2017
32
Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome. ( 28461505 )
2017
33
Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may vary across risk subgroups of childhood B-cell acute lymphoblastic leukemia. ( 27637012 )
2017
34
The Relationship Between MMP-2 -1306C>T and MMP-9 -1562C>T Polymorphisms and the Risk and Prognosis of T-Cell Acute Lymphoblastic Leukemia in a Chinese Population: A Case-Control Study. ( 28719899 )
2017
35
Upregulation of microRNA-21 is a poor prognostic marker in patients with childhood B cell acute lymphoblastic leukemia. ( 28253825 )
2017
36
Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia. ( 28270453 )
2017
37
Epigenetic targeting of Notch1 driven transcription using the HDACi panobinostat is a potential therapy against T cell acute lymphoblastic leukemia. ( 28914259 )
2017
38
Biomarker analysis and clinical relevance of TK1 on the cell membrane of Burkitt's lymphoma and acute lymphoblastic leukemia. ( 28919785 )
2017
39
Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia. ( 28923207 )
2017
40
Extramedullary Gastric Relapse at the Time of Bone Marrow Relapse of Acute Lymphoblastic Leukemia after Allogeneic Bone Marrow Transplantation. ( 28943549 )
2017
41
ZNF384-related fusion genes define a subgroup of childhood B-cell precursor acute lymphoblastic leukemia with a characteristic immunotype. ( 27634205 )
2017
42
Selected miRNA levels are associated with IKZF1 microdeletions in pediatric acute lymphoblastic leukemia. ( 28927157 )
2017
43
Survival Outcome of Filipino Children With Acute Lymphoblastic Leukemia Treated With Modified Berlin-Frankfurt-Muenster/Hong Kong Acute Lymphoblastic Leukemia (BFM95/HKALL97) Protocol in a Tertiary General Hospital From January 2005 to December 2009: A Retrospective Cohort Study. ( 28085747 )
2017
44
Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions. ( 28866095 )
2017
45
NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon. ( 27577869 )
2017
46
Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia. ( 29442455 )
2017
47
Adult pre B-cell acute lymphoblastic leukemia with unusually large proportion of bone marrow CD45 bright/high SSc blasts. ( 26415521 )
2017
48
Hypertriglyceridemia during asparaginase treatment in children with acute lymphoblastic leukemia correlates with antithrombin activity in adolescents. ( 28440015 )
2017
49
Blinatumomab Pharmacodynamics and Exposure-Response Relationships in Relapsed/Refractory Acute Lymphoblastic Leukemia. ( 28922466 )
2017
50
Severe hypertriglyceridemia during treatment of acute lymphoblastic leukemia associated with type III hyperlipoproteinemia. ( 28371240 )
2017

Variations for Lymphoblastic Leukemia

Expression for Lymphoblastic Leukemia

Search GEO for disease gene expression data for Lymphoblastic Leukemia.

Pathways for Lymphoblastic Leukemia

GO Terms for Lymphoblastic Leukemia

Cellular components related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 ABL1 AFF4 BCL9 IKZF1 LMO2 NBN
2 nucleus GO:0005634 9.6 ABL1 AFF1 AFF4 BAX BCL9 ETV6

Biological processes related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 transcription, DNA-templated GO:0006351 9.9 AFF4 ETV6 IKZF1 LYL1 NOTCH1 OLIG2
2 transcription by RNA polymerase II GO:0006366 9.88 AFF4 ETV6 PAX5 PBX1 RUNX1 TLX1
3 post-embryonic development GO:0009791 9.71 ABL1 BAX TAL2
4 B cell differentiation GO:0030183 9.69 FLT3 LYL1 TCF3
5 positive regulation of transcription by RNA polymerase II GO:0045944 9.65 BCL9 ETV6 IKZF1 LMO2 NOTCH1 PAX5
6 negative regulation of neuron differentiation GO:0045665 9.63 NOTCH1 OLIG2 PBX1
7 skeletal muscle cell differentiation GO:0035914 9.61 BCL9 NOTCH1 PAX5
8 thalamus development GO:0021794 9.56 OLIG2 TAL2
9 regulation of hematopoietic stem cell differentiation GO:1902036 9.56 ABL1 LMO2 RUNX1 TCF3
10 hematopoietic stem cell proliferation GO:0071425 9.55 ETV6 RUNX1
11 regulation of B cell receptor signaling pathway GO:0050855 9.52 PAX5 RUNX1
12 positive regulation of interferon-gamma secretion GO:1902715 9.48 ABL1 HMHB1
13 regulation of transcription, DNA-templated GO:0006355 9.47 ABL1 AFF1 AFF4 ETV6 IKZF1 LYL1
14 leukocyte homeostasis GO:0001776 9.37 BAX FLT3
15 apoptotic process involved in embryonic digit morphogenesis GO:1902263 9.32 BAX NOTCH1
16 cell differentiation GO:0030154 10.04 ETV6 FLT3 NOTCH1 PAX5 PBX1 TCF3
17 multicellular organism development GO:0007275 10.04 IKZF1 LMO2 NOTCH1 OLIG2 PAX5 PBX1

Molecular functions related to Lymphoblastic Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.9 ABL1 ETV6 IKZF1 LYL1 OLIG2 PAX5
2 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding GO:0001077 9.73 ETV6 PAX5 PBX1 TLX1
3 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.72 ETV6 PAX5 PBX1 TCF3 TLX1
4 protein dimerization activity GO:0046983 9.71 LYL1 OLIG2 TAL2 TCF3
5 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.67 ETV6 LMO2 LYL1 TAL2
6 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001190 9.46 LMO2 NOTCH1
7 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.43 ETV6 LMO2 LYL1 PBX1 RUNX1 TAL2
8 DNA binding transcription factor activity GO:0003700 9.32 AFF1 AFF4 ETV6 IKZF1 NOTCH1 OLIG2
9 protein binding GO:0005515 10.21 ABL1 AFF1 AFF4 BAX BCL9 ETV6

Sources for Lymphoblastic Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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