MCID: LYM040
MIFTS: 52

Lymphoblastic Lymphoma

Categories: Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Lymphoblastic Lymphoma

MalaCards integrated aliases for Lymphoblastic Lymphoma:

Name: Lymphoblastic Lymphoma 38 12 50 14
Precursor Cell Lymphoblastic Leukemia Lymphoma 69
Precursor Cell Lymphoblastic Lymphoma 69
Lymphoma, Lymphoblastic 50
Lymphoma Lymphoblastic 52

Classifications:



External Ids:

Disease Ontology 12 DOID:0080147
ICD10 33 C83.5

Summaries for Lymphoblastic Lymphoma

Disease Ontology : 12 A lymphoma that has material basis in immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage and located in primarily lymph nodes or located in extranodal sites.

MalaCards based summary : Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to thrombocytopenia and acute leukemia. An important gene associated with Lymphoblastic Lymphoma is ZMYM2 (Zinc Finger MYM-Type Containing 2), and among its related pathways/superpathways are NF-kappaB Signaling and Neural Crest Differentiation. The drugs Arranon and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and hematopoietic system

Related Diseases for Lymphoblastic Lymphoma

Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
id Related Disease Score Top Affiliating Genes
1 thrombocytopenia 29.8 BCL6 PTPRC
2 acute leukemia 29.0 FLI1 TAL1
3 t-cell childhood lymphoblastic lymphoma 12.2
4 precursor t-lymphoblastic lymphoma/leukemia 12.1
5 precursor b lymphoblastic lymphoma/leukemia 12.0
6 precursor lymphoblastic lymphoma/leukemia 11.9
7 childhood precursor t-lymphoblastic lymphoma/leukemia 11.9
8 precursor t-lymphoblastic lymphoma/leukemia refractory 11.9
9 chromosome 8p11 myeloproliferative syndrome 10.9
10 lymphoma 10.9
11 nontoxic goiter 10.5 FGFR1 MYC
12 leukemia 10.5
13 prostate cancer, hereditary, 13 10.4 FGFR1 ZMYM2
14 systemic mastocytosis with an associated clonal hematologic non-mast cell lineage disease 10.4 BCL6 KMT2A
15 lymphoblastic leukemia 10.4
16 coronin-1a deficiency 10.3 PTPRC TAL1
17 penile disease 10.2 BCL6 PTPRC
18 mediastinitis 10.2
19 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 BCL6 MME
20 childhood spinal cord tumor 10.2 BCL6 DNTT PTPRC
21 seckel syndrome 10 10.1 BCL6 DNTT MYC
22 plummer vinson syndrome 10.1 BCL6 NOTCH1 PTPRC
23 tang hsi ryu syndrome 10.1 BCL6 MME
24 estrogen-receptor positive breast cancer 10.1 BCL6 MYC PTPRC
25 primary malignant melanoma of the conjunctiva 10.1 BCL6 MYC
26 ovarian wilms' cancer 10.1 MME MYC PTPRC
27 paraneoplastic polyneuropathy 10.0 BCL6 PTPRC
28 hemolytic anemia 10.0 CDKN2B DNTT KMT2A NOTCH1
29 spondyloepimetaphyseal dysplasia, isidor type 10.0 FLI1 PTPRC
30 suppression amblyopia 10.0 MYC NOTCH1 TAL1
31 malignant melanocytic peripheral nerve sheath tumor of mediastinum 10.0 BCL6 MME MYC
32 blake pouch cyst 9.9 BCL6 KMT2A MME
33 pyridoxine-refractory autosomal recessive sideroblastic anemia 9.9 BCL6 FGFR1 MYC ZMYM2
34 gum cancer 9.9 MPO PTPRC
35 drug-induced hepatitis 9.9 BCL6 MME MYC
36 gastric small cell carcinoma 9.9 BCL6 MME PTPRC
37 gingival recession 9.9 BCL6 MME MYC
38 sarcoma 9.9
39 nelson syndrome 9.9 FGFR1 MPO ZMYM2
40 hodgkin's lymphoma, lymphocytic-histiocytic predominance 9.9 BCL6 PTPRC TRB
41 megakaryocytic leukemia 9.9 BCL6 MME MYC
42 cervicitis 9.9
43 thymoma 9.9
44 histiocytosis 9.9
45 hematopoietic stem cell transplantation 9.9
46 acute kidney failure 9.8 DNTT KMT2A MPO
47 acute necrotizing encephalopathy 9.8 DNTT KMT2A MPO
48 exertional headache 9.8 CDKN2B FLI1
49 myeloproliferative neoplasm 9.8
50 bipolar disorder 9.8 BCL6 MME MYC

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to Lymphoblastic Lymphoma

Symptoms & Phenotypes for Lymphoblastic Lymphoma

GenomeRNAi Phenotypes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.81 FGFR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.81 DNTT
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.81 NOTCH1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.81 DNTT
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.81 FGFR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.81 FGFR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.81 NOTCH1 DNTT
8 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.81 NOTCH1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.81 DNTT
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.81 DNTT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.81 DNTT
12 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.81 NOTCH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.81 FGFR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-178 9.81 MYC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.81 DNTT
16 Increased shRNA abundance (Z-score > 2) GR00366-A-183 9.81 FGFR1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.81 DNTT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.81 NOTCH1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.81 NOTCH1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.81 MYC
21 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.81 MYC
22 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.81 FGFR1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.81 FGFR1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.81 FGFR1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.81 NOTCH1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.81 FGFR1 MYC NOTCH1 DNTT
27 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.81 FGFR1

MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

44 (show all 13)
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.24 BCL6 CDKN2B DNTT FGFR1 FLI1 KMT2A
2 immune system MP:0005387 10.23 KMT2A MME MPO MYC NOTCH1 PTPRC
3 homeostasis/metabolism MP:0005376 10.22 BCL6 CDKN2B DNTT FGFR1 KMT2A MME
4 cardiovascular system MP:0005385 10.18 KMT2A MPO MYC NOTCH1 TAL1 BCL6
5 cellular MP:0005384 10.16 BCL6 CDKN2B FGFR1 FLI1 KMT2A MYC
6 mortality/aging MP:0010768 10.11 BCL6 CDKN2B FGFR1 FLI1 KMT2A MPO
7 integument MP:0010771 9.98 CDKN2B FGFR1 KMT2A MME MYC NOTCH1
8 liver/biliary system MP:0005370 9.95 BCL6 FLI1 KMT2A MME MYC NOTCH1
9 muscle MP:0005369 9.87 BCL6 FGFR1 FLI1 KMT2A MPO MYC
10 neoplasm MP:0002006 9.73 NOTCH1 PTPRC CDKN2B FLI1 KMT2A MYC
11 no phenotypic analysis MP:0003012 9.63 BCL6 CDKN2B FGFR1 KMT2A MYC PTPRC
12 normal MP:0002873 9.5 NOTCH1 PTPRC BCL6 DNTT FGFR1 KMT2A
13 renal/urinary system MP:0005367 9.1 CDKN2B FGFR1 KMT2A NOTCH1 PTPRC TAL1

Drugs & Therapeutics for Lymphoblastic Lymphoma

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Arranon 17 46 NELARABINE GlaxoSmithKline October 2005

Drugs for Lymphoblastic Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 542)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
2
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
3
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
4
Cytarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 147-94-4 6253
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
6
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
7
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
8
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
9
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
10
Asparaginase Approved Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
11
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
12
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
13
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
14
Cladribine Approved, Investigational Phase 4,Phase 2,Phase 1 4291-63-8 20279
15
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
16
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
17
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
18
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
19
Vindesine Approved Phase 4,Phase 3,Phase 2 59917-39-4, 53643-48-4 40839
20
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
21 Thiotepa Approved Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
22
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
23
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1 21679-14-1, 75607-67-9 30751
24
Idarubicin Approved Phase 4,Phase 3,Phase 2 58957-92-9 42890
25
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
26
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
27
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
28
Menthol Approved Phase 4 2216-51-5 16666
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
30
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
31
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
32
Treosulfan Investigational Phase 4,Phase 3,Phase 2 299-75-2 9296
33
Butyric Acid Experimental Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
34 Antilymphocyte Serum Phase 4,Phase 2,Phase 3,Phase 1
35 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
36 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
38 BB 1101 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
39 Dexamethasone acetate Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1177-87-3
40 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
41 Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
42 Antibodies Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
43
Ethylene Phase 4 74-85-1 6325
44 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
45 6-Mercaptopurine Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
47 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
48 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
49 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
50 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 1006)

id Name Status NCT ID Phase Drugs
1 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
2 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
3 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
4 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
5 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
6 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
7 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
8 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
9 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
10 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
11 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
12 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
13 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
14 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
15 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
16 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
17 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
18 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
19 Treatment of Acute Lymphoblastic Leukemia HIGH RISK BCR / ABL NEGATIVE IN ADULTS Recruiting NCT01540812 Phase 4 Vincristine in induction;Daunorubicin in induction;Prednisone in induction;Metotrexato in induction;Cytarabine in induction;Hydrocortisone in induction;Idarubicin in induction-2;Fludarabine in induction-2;Ara-C in induction-2;G-CSF in induction-2;Dexamethasone in consolidation-1;Vincristrine in consolidation-1;Metotrexato in consolidation-1;PEG-ASP in consolidation-1;Dexamethasone in consolidation-2;ARA-C in consolidation-2;PEG-ASP in consolidation-2;Dexamethasone in consolidation-3;Vincristine in consolidation-3;Metotrexato in consolidation-3;PEG-ASP in consolidation-3
20 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
21 Treatment of High Risk Adult Acute Lymphoblastic Leukemia Active, not recruiting NCT00853008 Phase 4 Vincristine;Daunorubicin;Prednisone;Mitoxantrone;Cytosine Arabinoside;Dexamethasone;Methotrexate (MTX);Cytarabine;ASP;Mercaptopurine;Teniposide;Hydrocortisone
22 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Not yet recruiting NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
23 Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma Unknown status NCT00003650 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisone;vincristine sulfate
24 Combination Chemotherapy Plus Steroid Therapy in Treating Children With Acute Lymphoblastic Leukemia or Lymphoblastic Non-Hodgkin's Lymphoma Unknown status NCT00003728 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;mitoxantrone hydrochloride;prednisolone;therapeutic hydrocortisone;thioguanine;vincristine sulfate;vindesine
25 Combination Chemotherapy in Treating Children With Non-Hodgkin's Lymphoma Unknown status NCT00003423 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;etoposide;mercaptopurine;methotrexate;prednisolone;thioguanine;vincristine sulfate
26 Radiolabeled Monoclonal Antibody in the Detection and Staging of Patients With Non-Hodgkin's Lymphoma Unknown status NCT00003337 Phase 3
27 Monoclonal Antibodies in Detecting Residual Disease in Patients Who Have Been Treated for Non-Hodgkin's Lymphoma Unknown status NCT00003338 Phase 2, Phase 3
28 Chemotherapy and Radiation Therapy Plus Bone Marrow Transplantation in Treating Patients With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00003815 Phase 3 carmustine;cyclophosphamide;cytarabine;doxorubicin hydrochloride;etoposide;melphalan;prednisolone;vincristine sulfate
29 Combination Chemotherapy With or Without Rituximab in Treating Older Patients With Non-Hodgkin's Lymphoma Unknown status NCT00052936 Phase 3 CHOP regimen;cyclophosphamide;doxorubicin hydrochloride;prednisone;vincristine sulfate
30 Combination Chemotherapy Followed By Radiation Therapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma Unknown status NCT00053768 Phase 3 EPOCH regimen;cyclophosphamide;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
31 Combination Chemotherapy With or Without Idarubicin and Peripheral Stem Cell Transplantation in Treating Patients With Leukemia or Myelodysplastic Syndrome Unknown status NCT00002989 Phase 3 busulfan;cyclophosphamide;idarubicin;melphalan
32 Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain Unknown status NCT01316744 Phase 3 ketamine hydrochloride
33 Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia Unknown status NCT00020865 Phase 3 cefepime hydrochloride;levofloxacin
34 Early Hospital Discharge or Standard Inpatient Care in Cancer Patients Receiving Antibiotics for Febrile Neutropenia Unknown status NCT00445497 Phase 3 amoxicillin-clavulanate potassium;ciprofloxacin
35 Interferon Alfa-2b Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Recurrent or Refractory Hodgkin's Disease or Non-Hodgkin's Lymphoma Unknown status NCT00003924 Phase 3
36 Treatment of Acute Lymphoblastic Leukemia or Aggressive Lymphoma With Relapse in Central Nervous System With Depocyt Unknown status NCT00199108 Phase 2, Phase 3 Depocyt;Dexamethasone
37 Phase III Study of Vincristine Sulfate Liposome For Injection In Adults With Naïve Acute Lymphoblastic Leukemia Unknown status NCT02072785 Phase 3 Vincristine Sulfate Liposome;Vincristine Sulfate
38 High-Dose Methotrexate (MTX) for Adult Acute Lymphoblastic Leukemia (ALL) Unknown status NCT00131027 Phase 3 Cyclophosphamide;Daunorubicin;Vincristine;Prednisolone;L-asparaginase;Cytarabine;Etoposide;Dexamethasone;Methotrexate;Mercaptopurine;Doxorubicin;Methotrexate
39 Hormone Therapy Plus Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia Unknown status NCT00003437 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;mercaptopurine;methotrexate;pegaspargase;prednisolone;thioguanine;vincristine sulfate
40 Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia Unknown status NCT00764907 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;etoposide;ifosfamide;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate;vindesine
41 Two Combination Chemotherapy Regimens in Treating Children With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00707083 Phase 3 dexamethasone;mercaptopurine;methotrexate;vincristine sulfate
42 Pegylated Liposomal Doxorubicin Versus Daunorubicin to Treat Acute Lymphoblastic Leukemia: Unknown status NCT02070523 Phase 3 VDCLD regimen
43 Allogeneic Stem Cell Transplantation in Children and Adolescents With Acute Lymphoblastic Leukaemia Unknown status NCT01423747 Phase 3 VP16;VP16, ATG;Fludarabine, OKT3, Treosulfan, Thiotepa;VP16, ATG
44 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
45 A Study of Actonel for the Prevention of Bone Loss Completed NCT00452439 Phase 3 Actonel (Risedronate)
46 Comparison of Two Combination Chemotherapy Regimens in Treating Adults With Previously Untreated Leukemia or Lymphoma Completed NCT00002766 Phase 3 carmustine;cyclophosphamide;cytarabine;daunorubicin hydrochloride;doxorubicin hydrochloride;etoposide;mercaptopurine;methotrexate;mitoxantrone hydrochloride;pegaspargase;prednisone;vincristine sulfate
47 Study of Treatment High Risk and/or Low Risk Acute Lymphoblastic leukémia(ALL) Adults Stage III Completed NCT00483132 Phase 3 interferon alpha 2a
48 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
49 Chemotherapy With or Without Bone Marrow Transplantation in Treating Patients With Acute Lymphoblastic Leukemia Completed NCT00002700 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;mitoxantrone hydrochloride;prednisolone;prednisone;therapeutic hydrocortisone;vincristine sulfate
50 Internet-Based Program With or Without Telephone-Based Problem-Solving Training in Helping Long-Term Survivors of Hematopoietic Stem Cell Transplant Cope With Late Complications Completed NCT00799461 Phase 3

Search NIH Clinical Center for Lymphoblastic Lymphoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Lymphoblastic Lymphoma

Anatomical Context for Lymphoblastic Lymphoma

MalaCards organs/tissues related to Lymphoblastic Lymphoma:

39
T Cells, B Cells, Bone, Bone Marrow, Myeloid, Kidney, B Lymphoblasts

Publications for Lymphoblastic Lymphoma

Articles related to Lymphoblastic Lymphoma:

(show top 50) (show all 610)
id Title Authors Year
1
Philadelphia chromosome-positive B-lymphoblastic lymphoma involving the genitourinary system and bone at initial diagnosis and relapse. ( 28935645 )
2017
2
T cell lymphoblastic lymphoma/leukemia within an adrenocorticotropic hormone and thyroid stimulating hormone positive pituitary adenoma: A cytohistological correlation emphasizing importance of intra-operative squash smear. ( 28295636 )
2017
3
The inhibitory effect of MEG3/miR-214/AIFM2 axis on the growth of T-cell lymphoblastic lymphoma. ( 28534937 )
2017
4
Primary T-cell Lymphoblastic Lymphoma of the Ovary: A Case Report. ( 28469345 )
2017
5
Bcl-2 maturation pattern in T-cells distinguishes thymic neoplasm/hyperplasia, T-lymphoblastic lymphoma, and reactive lymph nodes. ( 28718205 )
2017
6
Primary Cutaneous B-Cell Lymphoblastic Lymphoma Arising from a Long-Standing Lesion in a Child and Review of the Literature. ( 28547875 )
2017
7
Adult T-type lymphoblastic lymphoma: Treatment advances and prognostic indicators. ( 28412288 )
2017
8
Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. ( 28827401 )
2017
9
Safety and efficacy of nelarabine in children and young adults with relapsed or refractory T-lineage acute lymphoblastic leukaemia or T-lineage lymphoblastic lymphoma: results of a phase 4 study. ( 28771663 )
2017
10
Predictive value of (18)F-FDG PET/CT in adults with T-cell lymphoblastic lymphoma: post hoc analysis of results from the GRAALL-LYSA LLO3 trial. ( 28733763 )
2017
11
Clinical Features and Prognosis According to Immunophenotypic Subtypes Including the Early T-Cell Precursor Subtype of T-Lymphoblastic Lymphoma in the Japanese Pediatric Leukemia/Lymphoma Study Group ALB-NHL03 Study. ( 28538509 )
2017
12
B-cell lymphoblastic lymphoma presenting as solitary temporal mass with amplification of AML1/RUNX1: case report. ( 28933515 )
2017
13
Prognostic Factors and Outcomes of Adult Lymphoblastic Lymphoma in the United States. ( 28647403 )
2017
14
Synchronous T lymphoblastic lymphoma and myeloid neoplasm with PDGFRA rearrangement. ( 28013529 )
2017
15
PEG-asparaginase in BFM-90 regimen improves outcomes in adults with newly diagnosed lymphoblastic lymphoma. ( 28373755 )
2017
16
A Case of Cutaneous Involvement in T Lymphoblastic Lymphoma Leukemia. ( 28879704 )
2017
17
Ecthyma gangrenosum in a case of acute lymphoblastic lymphoma. ( 28052953 )
2017
18
Mathematical model of T-cell lymphoblastic lymphoma: disease, treatment, cure or relapse of a virtual cohort of patients. ( 28082512 )
2017
19
Immunophenotypic analysis of adult patients with T-cell lymphoblastic lymphoma treated with hyper-CVAD. ( 28778131 )
2017
20
Lymphoblastic lymphoma. ( 28427520 )
2017
21
B-lymphoblastic lymphoma of the rectum. ( 28670078 )
2017
22
Clinical characteristics and outcomes of previously untreated patients with adult onset T-acute lymphoblastic leukemia and T-lymphoblastic lymphoma with hyper-CVAD based regimens. ( 28646517 )
2017
23
A childhood chemotherapy protocol improves overall survival among adults with T-lymphoblastic lymphoma. ( 27150061 )
2016
24
Characteristics and outcomes of lymphoblastic lymphoma - the University of Miami experience. ( 27252116 )
2016
25
Deletion of Pten in CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies. ( 26773036 )
2016
26
Lymphoblastic lymphoma presenting as bilateral renal enlargement diagnosed by percutaneous kidney biopsy: Report of three cases. ( 27512306 )
2016
27
Clinical Outcomes after Allogeneic Stem Cell Transplantation for Adult Lymphoblastic Lymphoma. ( 27334855 )
2016
28
Immune Thrombocytopenia in a Child with T Cell Lymphoblastic Lymphoma. ( 27668103 )
2016
29
Lymphoblastic lymphoma with a triple hit profile: a rare but distinct and relevant entity. ( 27867103 )
2016
30
Deregulated FADD expression and phosphorylation in T-cell lymphoblastic lymphoma. ( 27556297 )
2016
31
Fluorine-18 fluorodeoxyglucose positron emission tomography imaging of T-lymphoblastic lymphoma patients. ( 27446482 )
2016
32
Precursor B-cell lymphoblastic lymphoma of oral cavity: A case report with its diagnostic workup. ( 27194876 )
2016
33
Effects of microRNA-21 on the biological functions of T-cell acute lymphoblastic lymphoma/leukemia. ( 27895788 )
2016
34
A T cell lymphoblastic lymphoma with mucormycosis as unusual etiology of acute cerebral ischemia. ( 26666534 )
2016
35
Precursor B-Cell Lymphoblastic Lymphoma Presenting as a Spinal Mass at Initial Diagnosis. ( 27094224 )
2016
36
Results of treatment of lymphoblastic lymphoma at the children cancer hospital Egypt - A single center experience. ( 27339800 )
2016
37
Successful use of extracorporeal membrane oxygenation during induction chemotherapy in a patient with mediastinal tumor mass of a T lymphoblastic lymphoma. ( 27324259 )
2016
38
Outcome of children and adolescents with lymphoblastic lymphoma. ( 27008495 )
2016
39
Primary orbital precursor T-cell lymphoblastic lymphoma: Report of a unique case. ( 27900092 )
2016
40
Myeloproliferative neoplasm with eosinophilia and T-lymphoblastic lymphoma with ETV6-LYN gene fusion. ( 27058227 )
2016
41
Imaging findings of childhood B-cell lymphoblastic lymphoma in the mental region: a case report. ( 27936917 )
2016
42
Terminal deoxynucleotidyl transferase (TDT)-negative t-cell lymphoblastic lymphoma does exist: A case report. ( 27772900 )
2016
43
When to Treat Adults Like Children: Optimizing Therapy for Lymphoblastic Lymphoma in Young Adults. ( 26700121 )
2016
44
Stem cell transplantation outcomes in lymphoblastic lymphoma. ( 27348707 )
2016
45
Primary T-cell lymphoblastic lymphoma in the middle ear. ( 26857309 )
2016
46
Lymphoblastic Lymphoma Presenting as Bilateral Ovarian Mass in an Adolescent Girl. ( 27965123 )
2016
47
Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study. ( 26644537 )
2016
48
Metachronous T-Lymphoblastic Lymphoma and Burkitt Lymphoma in a Child With Constitutional Mismatch Repair Deficiency Syndrome. ( 27037742 )
2016
49
Prognostic Impact of Intensified Maintenance Therapy on Children With Advanced Lymphoblastic Lymphoma: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group ALB-NHL03 Study. ( 26585702 )
2016
50
Genomic characterization of pediatric B-lymphoblastic lymphoma and B-lymphoblastic leukemia using formalin-fixed tissues. ( 27957801 )
2016

Variations for Lymphoblastic Lymphoma

Expression for Lymphoblastic Lymphoma

Search GEO for disease gene expression data for Lymphoblastic Lymphoma.

Pathways for Lymphoblastic Lymphoma

GO Terms for Lymphoblastic Lymphoma

Biological processes related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.92 BCL6 FGFR1 MYC NOTCH1 TAL1
2 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.85 CDKN2B FLI1 KMT2A MYC NOTCH1 TAL1
3 negative regulation of cell proliferation GO:0008285 9.84 BCL6 CDKN2B KMT2A NOTCH1
4 positive regulation of transcription, DNA-templated GO:0045893 9.62 KMT2A MYC NOTCH1 TAL1
5 positive regulation of mesenchymal cell proliferation GO:0002053 9.55 FGFR1 MYC
6 megakaryocyte development GO:0035855 9.49 FLI1 TAL1
7 definitive hemopoiesis GO:0060216 9.48 KMT2A TAL1
8 embryonic hemopoiesis GO:0035162 9.46 KMT2A TAL1
9 regulation of cell proliferation GO:0042127 9.46 BCL6 FGFR1 NOTCH1 TAL1
10 generation of neurons GO:0048699 9.4 FGFR1 TAL1
11 megakaryocyte differentiation GO:0030219 9.26 CDKN2B TAL1
12 regulation of gene expression GO:0010468 9.26 FGFR1 KMT2A MYC NOTCH1
13 regulation of transcription from RNA polymerase II promoter GO:0006357 9.1 BCL6 FLI1 MYC NOTCH1 TAL1 ZMYM2
14 regulation of transcription, DNA-templated GO:0006355 10.11 BCL6 FGFR1 FLI1 KMT2A MYC NOTCH1
15 transcription, DNA-templated GO:0006351 10.03 BCL6 FGFR1 FLI1 KMT2A MYC NOTCH1

Molecular functions related to Lymphoblastic Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor activity, sequence-specific DNA binding GO:0003700 9.63 BCL6 FLI1 KMT2A MYC NOTCH1 TAL1
2 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0000981 9.13 FLI1 TAL1 ZMYM2
3 chromatin binding GO:0003682 9.1 BCL6 FLI1 KMT2A MPO NOTCH1 TAL1

Sources for Lymphoblastic Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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