MCID: LYM040
MIFTS: 42

Lymphoblastic Lymphoma malady

Cancer diseases, Immune diseases categories

Summaries for Lymphoblastic Lymphoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphoblastic lymphoma is a rare type of non-Hodgkin lymphoma, a result of abnormal adaptive immune... more...

MalaCards: Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to lymphoblastic leukemia and leukemia. An important gene associated with Lymphoblastic Lymphoma is PTPRJ (protein tyrosine phosphatase, receptor type, J), and among its related pathways are Validated targets of C-MYC transcriptional repression and p53 Pathway. The drugs cyclophosphamide and ifosfamide and the compounds tal 2 and etoposide have been mentioned in the context of this disorder. Affiliated tissues include t cells and bone, and related mouse phenotypes are embryogenesis and cellular.

Aliases & Classifications for Lymphoblastic Lymphoma

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42NIH Rare Diseases, 30LifeMap Discovery™, 44Novoseek, 60UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphoblastic lymphoma 42 30
precursor cell lymphoblastic leukemia lymphoma 60
lymphoma, lymphoblastic 42
lymphoma lymphoblastic 44


External Ids:

ICD1025 C83.5

Related Diseases for Lymphoblastic Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1lymphoblastic leukemia31.4TLX1
2leukemia31.4TLX1, CTRL, GADD45A, DNTT, CASP5, MNDA
3acute leukemia31.2LMO2, CD7, CDKN2B, RAG1, DNTT, TAL1
4t-cell leukemia31.1LMO2, TAL1, CD7, TLX1, RAG1
5burkitt's lymphoma30.6DNTT, GADD45A, MNDA, RAG1
6myeloid leukemia30.5CDKN2B, DNTT, MNDA
7acute lymphocytic leukemia30.3DNTT, LMO2, CDKN2B, TAL1, CD7, RAG1
8non-hodgkin lymphoma30.3DNTT, CDKN2B, TAL1, RAG1
9chronic myeloid leukemia30.2DNTT, MNDA, TAL1, CDKN2B
10adenoma29.9ASCL1, PTPRJ, ENO2
11adult lymphoma10.9
12bone lymphoma10.7
13acute t cell leukemia10.6
14mediastinitis10.6
15pediatric lymphoma10.5
16precursor lymphoblastic lymphoma/leukemia10.4
17precursor b lymphoblastic lymphoma/leukemia10.4
18precursor t-lymphoblastic lymphoma/leukemia10.4
19sarcoma10.4
20breast lymphoma10.3
21cervicitis10.3
22histiocytosis10.3
23thymus lymphoma10.3
24eosinophilia10.3
25hodgkin's lymphoma10.3
26thymoma10.3
27graft versus host disease10.2
28central nervous system lymphoma10.2
29acute myeloid leukemia10.2
30precursor t-lymphoblastic lymphoma/leukemia refractory10.2
31orbit lymphoma10.2
32malignant histiocytosis10.2
33spinal cord lymphoma10.2
34myasthenia gravis10.2
35testicular lymphoma10.1
36childhood precursor t-lymphoblastic lymphoma/leukemia10.1
37intussusception10.1
38diffuse large b-cell lymphoma10.1
39langerhans-cell histiocytosis10.1
40t cell deficiency10.1
41merkel cell carcinoma10.0ENO2
42cerebral primitive neuroectodermal tumor10.0ENO2, CD99
43acute lymphoblastic leukemia, childhood10.0DNTT, RAG1, CDKN2B, TLX1
44central nervous system cancer10.0ENO2
45breast cancer10.0CTRL, LMO2, S1PR1, GADD45A
46olfactory neuroblastoma10.0CD99, ENO2
47medulloblastoma10.0DNTT, CDKN2B, ENO2
48ovarian cancer10.0S1PR1, GADD45A
49prostate cancer10.0GADD45A, ENO2, CDKN2B, CTRL
50precursor t-cell acute lymphoblastic leukemia10.0TAL1, CDKN2B, LMO2, TLX1, DNTT, CD7

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to lymphoblastic lymphoma

Clinical Features for Lymphoblastic Lymphoma

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Drugs & Therapeutics for Lymphoblastic Lymphoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lymphoblastic Lymphoma

Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Lymphoma

Search NIH Clinical Center for Lymphoblastic Lymphoma

Search CenterWatch for Lymphoblastic Lymphoma

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Lymphoblastic Lymphoma

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Anatomical Context for Lymphoblastic Lymphoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Lymphoblastic Lymphoma:

32
T cells, Bone

Animal Models for Lymphoblastic Lymphoma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.2S1PR1, GADD45A, ITGB7, LMO2, PTPRJ, TLX1
2MP:00053849.9ASCL1, TLX1, S1PR1, GADD45A, ITGB7, DNTT
3MP:00053979.9TLX1, S1PR1, GADD45A, ITGB7, DNTT, CDKN2B
4MP:00053879.7ITGB7, GADD45A, S1PR1, TLX1, DNTT, CDKN2B

Publications for Lymphoblastic Lymphoma

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Genetic Variations for Lymphoblastic Lymphoma

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Expression for genes affiliated with Lymphoblastic Lymphoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoblastic Lymphoma

Search GEO for disease gene expression data for Lymphoblastic Lymphoma.

Pathways for genes affiliated with Lymphoblastic Lymphoma

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Sources:
37NCBI BioSystems Database, 55SinoBiological, 51QIAGEN, 53Reactome
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Pathways related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3GADD45A, DNTT, CDKN2B
2
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10.3GADD45A, PSMB5, CASP5
3
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10.3CDT1, CDKN2B, GADD45A, PSMB5

Compounds for genes affiliated with Lymphoblastic Lymphoma

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Sources:
44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tal 24410.4LMO2, TAL1
2etoposide44 49 59 1113.3ENO2, TAL1, DNTT, GADD45A
3tyrosine4410.1ASCL1, TLX1, S1PR1, CTRL, GADD45A, ITGB7
4retinoic acid44 2411.1CTRL, GADD45A, DNTT, CDKN2B, TAL1, ENO2
5zinc44 2410.9TLX1, CTRL, GADD45A, DNTT, LMO2, RAG1

GO Terms for genes affiliated with Lymphoblastic Lymphoma

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Sources:
16Gene Ontology
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Biological processes related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:03516210.4LMO2, TAL1
2megakaryocyte differentiationGO:03021910.3CDKN2B, TAL1
3positive regulation of transcription from RNA polymerase II promoterGO:04594410.2ASCL1, LMO2, TAL1, CDKN2B, S1PR1, TLX1
4spinal cord association neuron differentiationGO:02152710.1ASCL1, TAL1

Molecular functions related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:04342510.4ASCL1, LMO2
2E-box bindingGO:07088810.2ASCL1, LMO2, TAL1
3protein bindingGO:0055159.6TLX1, PSMB5, GADD45A, ITGB7, MNDA, CDKN2B

Products for genes affiliated with Lymphoblastic Lymphoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphoblastic Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet