MCID: LYM040
MIFTS: 54

Lymphoblastic Lymphoma malady

Cancer, Immune categories

Summaries for Lymphoblastic Lymphoma

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Lymphoblastic lymphoma is a rare type of non-Hodgkin lymphoma, a result of abnormal adaptive immune... more...

MalaCards: Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to acute leukemia and t-cell leukemia. An important gene associated with Lymphoblastic Lymphoma is PTPRJ (protein tyrosine phosphatase, receptor type, J), and among its related pathways are Validated targets of C-MYC transcriptional repression and p53 Pathway. The drugs cyclophosphamide and ifosfamide and the compounds tal 2 and etoposide have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are embryogenesis and cellular.

Aliases & Classifications for Lymphoblastic Lymphoma

Sources:
43NIH Rare Diseases, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Immune


Aliases & Descriptions:

lymphoblastic lymphoma 43 31
precursor cell lymphoblastic leukemia lymphoma 61
lymphoma, lymphoblastic 43
lymphoma lymphoblastic 45


External Ids:

ICD1025 C83.5

Related Diseases for Lymphoblastic Lymphoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia31.2DNTT, CDKN2B, CD7, TAL1, LMO2, RAG1
2t-cell leukemia30.9TLX1, CD7, TAL1, LMO2, RAG1
3burkitt's lymphoma30.5GADD45A, DNTT, MNDA, RAG1
4acute lymphocytic leukemia30.2DNTT, CDKN2B, CD7, TAL1, LMO2, RAG1
5chronic myeloid leukemia30.2DNTT, MNDA, CDKN2B, TAL1
6precursor t-cell acute lymphoblastic leukemia30.0TLX1, DNTT, CDKN2B, CD7, TAL1, LMO2
7leukemia, acute nonlymphocytic30.0CD7, DNTT
8adenoma30.0PTPRJ, ENO2, ASCL1
9adult lymphoma10.9
10bone lymphoma10.7
11leukemia/lymphoma, t-cell10.6
12pediatric lymphoma10.6
13precursor b lymphoblastic lymphoma/leukemia10.4
14acute t cell leukemia10.4
15breast lymphoma10.3
16thymus lymphoma10.3
17adult t-cell leukemia10.3
18thymoma10.3
19graft versus host disease10.2
20colon lymphoma10.2
21central nervous system lymphoma10.2
22acute myeloid leukemia10.2
23precursor t-lymphoblastic lymphoma/leukemia refractory10.2
24orbit lymphoma10.2
25malignant histiocytosis10.2
26spinal cord lymphoma10.2
27hematopoietic stem cell transplantation10.2
28testicular lymphoma10.1
29childhood precursor t-lymphoblastic lymphoma/leukemia10.1
30intussusception10.1
31acute biphenotypic leukemia10.1
32acute graft versus host disease10.1
33b-cell lymphomas10.1
34leukemia, b-cell, chronic10.1
35leukemia, t-cell, chronic10.1
36follicular lymphoma10.1
37hypereosinophilic syndrome10.1
38myeloproliferative disorder10.1
39lymphoma, diffuse large cell10.1
40lymphoid leukemia10.0
41neurofibromatosis10.0
42strongyloidiasis10.0
43granulomatous angiitis10.0
44fg syndrome10.0
45trichosporonosis10.0
46thyroid lymphoma10.0
47trachoma10.0
48friedreich ataxia10.0
49sagittal sinus thrombosis10.0
50liver lymphoma10.0

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to lymphoblastic lymphoma

Clinical Features for Lymphoblastic Lymphoma

Drugs & Therapeutics for Lymphoblastic Lymphoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphoblastic Lymphoma

Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Lymphoma

Search NIH Clinical Center for Lymphoblastic Lymphoma

Search CenterWatch for Lymphoblastic Lymphoma

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Lymphoblastic Lymphoma

Anatomical Context for Lymphoblastic Lymphoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Lymphoblastic Lymphoma:

33
Skin, Ovary, Liver, Tongue, Spinal cord, Kidney, Lymph node, Spleen, Uterus, Bone marrow, Thymus, Heart, Small intestine, Colon, Thyroid, Breast, Myeloid, Nk cells, T cells, B lymphoblasts, B cells, Pituitary, Uterus corpus

Animal Models for Lymphoblastic Lymphoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538010.2S1PR1, GADD45A, ITGB7, LMO2, PTPRJ, TLX1
2MP:00053849.9ASCL1, TLX1, S1PR1, GADD45A, ITGB7, DNTT
3MP:00053979.9LMO2, TAL1, CD7, CDKN2B, DNTT, ITGB7
4MP:00053879.7LMO2, TLX1, PTPRJ, RAG1, TAL1, CD7

Publications for Lymphoblastic Lymphoma

Sources:
51PubMed
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Articles related to Lymphoblastic Lymphoma:

(show top 50)    (show all 578)
idTitleAuthorsYear
1
PET-MRI hybrid imaging in a rare case of B cell lymphoblastic lymphoma with musculoskeletal manifestation. (23775582)
2013
2
Multimodal treatment with ALL-like chemotherapy, Auto-SCT and radiotherapy for lymphoblastic lymphoma. (24237392)
2013
3
Indolent T-lymphoblastic proliferation (iT-LBP): a review of clinical and pathologic features and distinction from malignant T-lymphoblastic lymphoma. (23574769)
2013
4
Lymphoblastic lymphoma in childhood and adolescence. (23621872)
2013
5
Concurrent acute myeloid leukemia and T lymphoblastic lymphoma in a patient with rearranged PDGFRB genes. (22356850)
2012
6
Results of the Japan Association of Childhood Leukemia Study (JACLS) NHL-98 protocol for the treatment of B-cell non-Hodgkin lymphoma and mature B-cell acute lymphoblastic leukemia in childhood. (21261497)
2011
7
PDGFRA rearrangement leading to hyper-eosinophilia, T-lymphoblastic lymphoma, myeloproliferative neoplasm and precursor B-cell acute lymphoblastic leukemia. (21304535)
2011
8
Composite diffuse large B-cell lymphoma and precursor B lymphoblastic lymphoma presenting as a double-hit lymphoma with MYC and BCL2 translocation. (21778297)
2011
9
Guillain-BarrAc syndrome mimicking acute methotrexate-associated encephalopathy in an adolescent patient with lymphoblastic lymphoma. (20463610)
2010
10
Differential effects of BAFF on B cell precursor acute lymphoblastic leukemia and Burkitt lymphoma. (20428981)
2010
11
Case series: acute tumor lysis syndrome in mutator mice with disseminated lymphoblastic lymphoma. (20190201)
2010
12
Pre-treatment serum levels of interleukin-10, interleukin-12 and their ratio predict response to therapy and probability of event-free and overall survival in childhood soft tissue sarcomas, Hodgkin's lymphomas and acute lymphoblastic leukemias. (19376105)
2009
13
An unusual presentation of extramedullary biphenotypic lymphoblastic lymphoma. (19650115)
2009
14
Intensive chemotherapy improved treatment outcome for Chinese children and adolescents with lymphoblastic lymphoma. (18946754)
2008
15
Spontaneous remission of T lymphoblastic lymphoma. (18663057)
2008
16
Shortened intensified multi-agent chemotherapy and non-cross resistant maintenance therapy for advanced lymphoblastic lymphoma in children and adolescents: report from the Children's Oncology Group. (18759768)
2008
17
Case report of precursor B-cell lymphoblastic lymphoma presenting as syncope and cardiac mass in a nonimmunocompromised child. (17726421)
2007
18
Precursor B-cell lymphoblastic lymphoma involving the skin. (16965342)
2006
19
Alendronate for steroid-induced osteopenia in children with acute lymphoblastic leukaemia or non-Hodgkin's lymphoma: results of a pilot study. (16460605)
2005
20
Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53. (16261166)
2005
21
Fine needle aspiration biopsy of precursor B-cell lymphoblastic lymphoma presenting as a sacral mass. A case report. (15085760)
2004
22
Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma. (15178574)
2004
23
Unusual presentations of hematologic malignancies: CASE 2. Precursor B-cell lymphoblastic lymphoma presenting as spinal cord compression. (15051782)
2004
24
Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocols for acute lymphoblastic leukemia. (12036865)
2002
25
Epstein-Barr virus-negative precursor B cell lymphoblastic lymphoma after liver transplantation: a unique form of posttransplant lymphoproliferative disease. (11889425)
2002
26
Value of high-dose cytarabine during interval therapy of a Berlin-Frankfurt-Munster-based protocol in increased-risk children with acute lymphoblastic leukemia and lymphoblastic lymphoma: results of the European Organization for Research and Treatment of Cancer 58881 randomized phase III trial. (11283125)
2001
27
Successful allogeneic bone marrow transplantation in a case of adult precursor B-lymphoblastic lymphoma. (11197221)
2000
28
Diffuse kidney infiltration with T-cell lymphoblastic lymphoma. (9681755)
1998
29
Acute lymphoblastic leukemia/lymphoblastic lymphoma of natural killer (NK) lineage: quest for another NK-lineage neoplasm. (9192799)
1997
30
Expression of A-myb, but not c-myb and B-myb, is restricted to Burkitt's lymphoma, sIg+ B-acute lymphoblastic leukemia, and a subset of chronic lymphocytic leukemias. (8634438)
1996
31
Human T-cell lymphoblastic lymphoma expressing the T-cell receptor gamma/delta established in immune-deficient (bg/nu/xid) mice. (8381196)
1993
32
Lymphoblastic lymphoma in a colony of N:NIH(S)-bg-nu-xid mice. (1434498)
1992
33
T-cell acute lymphoblastic lymphoma induced in transgenic mice by the RBTN1 and RBTN2 LIM-domain genes. (1461647)
1992
34
Prethymic adult lymphoblastic lymphoma. A clinicopathologic and immunohistochemical analysis. (1471728)
1992
35
Adult lymphoblastic lymphoma: high incidence of central nervous system relapse in patients treated with the Stanford University protocol. (1286046)
1992
36
Autologous bone marrow transplantation for advanced stage adult lymphoblastic lymphoma in first complete remission. Report of the Non-Hodgkin's Lymphoma Cooperative Study Group (NHLCSG). (2049316)
1991
37
Lymphoblastic lymphoma presenting in cutaneous sites. A clinicopathologic analysis of six cases. (1810981)
1991
38
Utilization of two different T cell receptors by T cell acute lymphoblastic lymphoma and leukemia. (2099407)
1990
39
Lymphoblastic lymphoma. (2406921)
1990
40
Bone marrow transplantation for adult poor prognosis lymphoblastic lymphoma in first complete remission. (2803982)
1989
41
Poor-risk non-lymphoblastic lymphoma of childhood: results of an intensive pilot study. (2913472)
1989
42
Antigenically defined subgroups of lymphoblastic lymphoma. Relationship to clinical presentation and biologic behavior. (2954631)
1987
43
Treatment of lymphoblastic lymphoma in adults. (3772416)
1986
44
Lymphoblastic lymphoma: an immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemia. (3080041)
1986
45
Parosteal lymphoblastic lymphoma. A human counterpart of Abelson virus-induced lymphosarcoma of mice. (6610472)
1984
46
Severe hypophosphataemia in T-cell lymphoblastic lymphoma. (6401477)
1983
47
Lymphoblastic lymphoma/leukemia of T-cell origin: ultrastructural, cytochemical, and immunologic features of ten cases. (6975156)
1981
48
Lymphoblastic lymphoma in adults. (7272902)
1981
49
Identification of lymphoblastic lymphoma cells using a dual assay for T cell differentiation markers. (315815)
1979
50
The lymphoblastic lymphoma of childhood. (4158833)
1965

Genetic Variations for Lymphoblastic Lymphoma

Expression for genes affiliated with Lymphoblastic Lymphoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphoblastic Lymphoma

Search GEO for disease gene expression data for Lymphoblastic Lymphoma.

Pathways for genes affiliated with Lymphoblastic Lymphoma

Sources:
38NCBI BioSystems Database, 56SinoBiological, 52QIAGEN, 54Reactome
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Pathways related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3GADD45A, DNTT, CDKN2B
2
Hide members
10.3CASP5, PSMB5, GADD45A
3
Hide members
10.3PSMB5, GADD45A, CDKN2B, CDT1

Compounds for genes affiliated with Lymphoblastic Lymphoma

Sources:
45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB
See all sources

Compounds related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tal 24510.4LMO2, TAL1
2etoposide45 50 60 1113.3ENO2, TAL1, DNTT, GADD45A
3tyrosine4510.1ASCL1, TLX1, S1PR1, CTRL, GADD45A, ITGB7
4retinoic acid45 2411.1CTRL, GADD45A, DNTT, CDKN2B, TAL1, ENO2
5zinc45 2410.9TLX1, CTRL, GADD45A, DNTT, LMO2, RAG1

GO Terms for genes affiliated with Lymphoblastic Lymphoma

Sources:
16Gene Ontology
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Biological processes related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1embryonic hemopoiesisGO:03516210.4TAL1, LMO2
2megakaryocyte differentiationGO:03021910.3CDKN2B, TAL1
3positive regulation of transcription from RNA polymerase II promoterGO:04594410.2TLX1, S1PR1, CDKN2B, TAL1, LMO2, ASCL1
4spinal cord association neuron differentiationGO:02152710.1TAL1, ASCL1

Molecular functions related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bHLH transcription factor bindingGO:04342510.4ASCL1, LMO2
2E-box bindingGO:07088810.2TAL1, LMO2, ASCL1
3protein bindingGO:0055159.6TLX1, PSMB5, GADD45A, ITGB7, MNDA, CDKN2B

Products for genes affiliated with Lymphoblastic Lymphoma

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  • Antibodies

Sources for Lymphoblastic Lymphoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet