MCID: LYM040
MIFTS: 54

Lymphoblastic Lymphoma malady

Rare diseases, Cancer diseases, Immune diseases categories
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Summaries for Lymphoblastic Lymphoma

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65Wikipedia, 33MalaCards
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Wikipedia:65 Lymphoblastic lymphoma is a rare type of non-Hodgkin lymphoma, a result of abnormal adaptive immune... more...

MalaCards: Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to leukemia and burkitt's lymphoma. An important gene associated with Lymphoblastic Lymphoma is PTPRJ (protein tyrosine phosphatase, receptor type, J), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and Validated targets of C-MYC transcriptional repression. The drugs cyclophosphamide and ifosfamide and the compounds tcdd and probenecid have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are integument and normal.

Aliases & Classifications for Lymphoblastic Lymphoma

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43NIH Rare Diseases, 31LifeMap Discovery™, 45Novoseek, 62UMLS, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphoblastic lymphoma 43 31
precursor cell lymphoblastic leukemia lymphoma 62
lymphoma, lymphoblastic 43
lymphoma lymphoblastic 45


External Ids:

ICD1025 C83.5

Related Diseases for Lymphoblastic Lymphoma

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17GeneCards, 18GeneDecks
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Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.4DNTT, RAG1, CDKN2B, CTRL
2burkitt's lymphoma30.6RAG1, DNTT
3acute leukemia30.3DNTT, RAG1, CDKN2B, CD8A
4myelodysplastic syndromes30.3CDKN2B, DNTT
5precursor t-cell acute lymphoblastic leukemia30.2CDKN2B, RAG1, DNTT
6non-hodgkin lymphoma30.2DNTT, RAG1, CDKN2B
7acute lymphocytic leukemia30.2CDKN2B, RAG1, DNTT
8chronic lymphocytic leukemia30.0CDKN2B, DNTT
9lymphoblastic leukemia10.8
10mediastinitis10.7
11precursor t-lymphoblastic lymphoma/leukemia10.4
12sarcoma10.4
13precursor b lymphoblastic lymphoma/leukemia10.4
14cervicitis10.4
15histiocytosis10.4
16eosinophilia10.3
17hodgkin's lymphoma10.3
18thymoma10.3
19graft versus host disease10.2
20precursor t-lymphoblastic lymphoma/leukemia refractory10.2
21malignant histiocytosis10.2
22myasthenia gravis10.2
23myeloid leukemia10.2
24hematopoietic stem cell transplantation10.2
25langerhans-cell histiocytosis10.2
26follicular lymphoma10.2
27childhood precursor t-lymphoblastic lymphoma/leukemia10.2
28intussusception10.2
29diffuse large b-cell lymphoma10.2
30precursor lymphoblastic lymphoma/leukemia10.2
31acute biphenotypic leukemia10.2
32b-cell lymphomas10.2
33hypereosinophilic syndrome10.2
34myeloproliferative disorder10.2
35multiple myeloma10.1CTRL
36leukemia, acute lymphoblastic 310.0CDKN2B, DNTT
37hematologic cancer10.0DNTT, CDKN2B
38neurofibromatosis10.0
39granulomatous angiitis10.0
40strongyloidiasis10.0
41pemphigus10.0
42chronic myeloid leukemia10.0
43nasopharyngitis10.0
44type 1 diabetes mellitus10.0
45mycosis fungoides10.0
46myeloid sarcoma10.0
47lymphosarcoma10.0
48hypercalcemia10.0
49churg-strauss syndrome10.0
50trichosporonosis10.0

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to lymphoblastic lymphoma

Symptoms for Lymphoblastic Lymphoma

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Drugs & Therapeutics for Lymphoblastic Lymphoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Lymphoma

Search NIH Clinical Center for Lymphoblastic Lymphoma

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Lymphoblastic Lymphoma

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Anatomical Context for Lymphoblastic Lymphoma

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33MalaCards
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MalaCards organs/tissues related to Lymphoblastic Lymphoma:

33
T cells, B cells, Bone, B lymphoblasts, Bone marrow, Myeloid, Breast, Skin, Thymus, Ovary, Kidney, Spinal cord, Uterus, Pituitary, Tongue, Eye, Lymph node, Spleen, Nk cells, Heart, Small intestine, Colon, Liver, Thyroid

Animal Models for Lymphoblastic Lymphoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1CD8A, CDKN2B, RAG1, ASCL1
2MP:00028737.8CD8A, RAG1, DNTT, ASCL1, PTPRJ
3MP:00053977.6PTPRJ, DNTT, RAG1, CDKN2B, CD8A
4MP:00053877.4PTPRJ, DNTT, RAG1, CDKN2B, CD8A

Publications for Lymphoblastic Lymphoma

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52PubMed
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Articles related to Lymphoblastic Lymphoma:

(show top 50)    (show all 487)
idTitleAuthorsYear
1
Sudden extramedullary blast crisis of chronic myeloid leukemia manifesting as T-cell lymphoblastic lymphoma. (23486000)
2013
2
Isolated primary testicular B lymphoblastic lymphoma: an unusual presentation. (23042023)
2013
3
Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development. (23288923)
2013
4
Cutaneous B-cell lymphoblastic lymphoma in children: a rare diagnosis. (21745698)
2012
5
Acute kidney injury and bilateral symmetrical enlargement of the kidneys as first presentation of B-cell lymphoblastic lymphoma. (22835902)
2012
6
Primary cutaneous precursor B-cell lymphoblastic lymphoma with late dissemination. (22159948)
2011
7
Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404). (21474675)
2011
8
Primary precursor B cell lymphoblastic lymphoma of uterine corpus: case report and review of the literature. (21193918)
2011
9
8p11 Myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: a case report and review of the literature. (21239058)
2011
10
Modulation of the Fas-apoptosis-signalling pathway by functional polymorphisms at Fas, FasL and Fadd and their implication in T-cell lymphoblastic lymphoma susceptibility. (20889682)
2010
11
Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. (19825456)
2009
12
T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity? (19778844)
2009
13
Bone marrow minimal disseminated disease (MDD) and minimal residual disease (MRD) in childhood T-cell lymphoblastic lymphoma stage III, detected by flow cytometry (FC) and real-time quantitative polymerase chain reaction (RQ-PCR). (19006253)
2009
14
Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. (18502982)
2008
15
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. (18663146)
2008
16
A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. (17890450)
2008
17
Primary cutaneous B-cell lymphoblastic lymphoma. (19171997)
2008
18
Characterization of childhood precursor T-lymphoblastic lymphoma by immunophenotyping and fluorescent in situ hybridization: a report from the Children's Oncology Group. (18618503)
2008
19
Terminal deoxynucleotidyl transferase negative T-cell lymphoblastic lymphoma in aleukemic patient. (18512118)
2008
20
T-cell lymphoblastic lymphoma presenting as an intra-muscular mass. (16445824)
2006
21
An adult case of precursor B cell lymphoblastic lymphoma extending from right neck to upper cervical spinal region]. (16277225)
2005
22
CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features. (16046525)
2005
23
Unusual abdominal tumors, case 3. Primary omental T-cell lymphoblastic lymphoma. (15084627)
2004
24
Fine needle aspiration biopsy of precursor B-cell lymphoblastic lymphoma presenting as a sacral mass. A case report. (15085760)
2004
25
Cutaneous lymphoblastic lymphoma of putative plasmacytoid dendritic cell-precursor origin: two cases. (12008089)
2002
26
Differentiating lymphoblastic lymphoma and Ewing's sarcoma: lymphocyte markers and gene rearrangement. (11706081)
2001
27
Immunoperoxidase detection of CD10 in Precursor T-lymphoblastic lymphoma/leukemia: a clinicopathologic study of 24 cases. (10782151)
2000
28
Friedreich's ataxia and intrathecal chemotherapy in a patient with lymphoblastic lymphoma. (10631473)
1999
29
Lymphoblastic lymphoma expressing CD56 and TdT. (9422326)
1998
30
Lymphoblastic lymphoma of natural killer cell origin, presenting as pancreatic tumour. (9675589)
1998
31
Acute myelogenous leukemia with monosomy 7, inv(3) (q21q26), involving activated EVI 1 gene occurring after a complete remission of lymphoblastic lymphoma: a case report. (9861236)
1998
32
Primary unilateral renal lymphoblastic lymphoma. (8995162)
1997
33
Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. (9227346)
1997
34
Acute tumor lysis syndrome in high grade lymphoblastic lymphoma after a prolonged episode of fever. (8614380)
1996
35
A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones. (8656689)
1996
36
Childhood T-cell lymphoblastic lymphoma--does early resolution of mediastinal mass predict for final outcome? The United Kingdom Children's Cancer Study Group (UKCCSG). (7669589)
1995
37
Human T-cell lymphoblastic lymphoma expressing the T-cell receptor gamma/delta established in immune-deficient (bg/nu/xid) mice. (8381196)
1993
38
Lymphoblastic lymphoma. (8102865)
1993
39
Lineage alteration in precursor B cell acute lymphoblastic leukemia following T cell lymphoblastic lymphoma. (1333557)
1992
40
Lymphoblastic lymphoma with primary splenic involvement and the classic 14;18 translocation. (1756484)
1991
41
Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma. (1701841)
1990
42
Utilization of two different T cell receptors by T cell acute lymphoblastic lymphoma and leukemia. (2099407)
1990
43
Intracytoplasmic localization of CD3 antigen in NKH1+ azurophilic granular T-lymphoblastic lymphoma cells. (2533446)
1989
44
Bone marrow transplantation for adult poor prognosis lymphoblastic lymphoma in first complete remission. (2803982)
1989
45
Improved treatment results for lymphoblastic lymphoma in adolescents and adults using a doxorubicin-based (APO) protocol. (3196243)
1988
46
Extranodal non-T-cell lymphoblastic lymphoma in adults. A report of two cases. (3052024)
1988
47
Treatment of lymphoblastic lymphoma in adults. (3772416)
1986
48
Lymphoblastic lymphoma: an immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemia. (3080041)
1986
49
Pseudonodular T cell lymphoblastic lymphoma. (6333817)
1984
50
Mediastinal mass with acute leukemia. Myeloblastoma masquerading as lymphoblastic lymphoma. (6937159)
1981

Variations for Lymphoblastic Lymphoma

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Expression for genes affiliated with Lymphoblastic Lymphoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoblastic Lymphoma

Search GEO for disease gene expression data for Lymphoblastic Lymphoma.

Pathways for genes affiliated with Lymphoblastic Lymphoma

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.5CDT1, CDKN2B
29.4CDKN2B, DNTT
39.3CD8A, DNTT
4
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.1CDKN2B, RAG1
59.0CD8A, RAG1

Compounds for genes affiliated with Lymphoblastic Lymphoma

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45Novoseek, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tcdd459.2RAG1, DNTT
2probenecid29 45 61 51 1113.1DNTT, RAG1
3cytidine45 24 1111.0RAG1, DNTT
4retinoic acid45 249.8ASCL1, DNTT, CDKN2B, CTRL
5zinc45 249.8CTRL, RAG1, DNTT
6serine458.4PTPRJ, DNTT, CDKN2B, CTRL
7tyrosine458.4CTRL, CD8A, CDKN2B, ASCL1, PTPRJ

GO Terms for genes affiliated with Lymphoblastic Lymphoma

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16Gene Ontology
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Molecular functions related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:0199019.0CD8A, CDKN2B, PTPRJ
2protein homodimerization activityGO:0428038.3ASCL1, RAG1, CD8A
3DNA bindingGO:0036778.2CDT1, RAG1, DNTT, ASCL1
4protein bindingGO:0055157.3CD8A, CDKN2B, CDT1, RAG1, ASCL1, PTPRJ

Products for genes affiliated with Lymphoblastic Lymphoma

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Sources for Lymphoblastic Lymphoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet