MCID: LYM040
MIFTS: 54

Lymphoblastic Lymphoma malady

Rare diseases, Cancer diseases, Immune diseases categories
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Summaries for Lymphoblastic Lymphoma

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Wikipedia:65 Lymphoblastic lymphoma is a rare type of non-Hodgkin lymphoma, a result of abnormal adaptive immune... more...

MalaCards based summary: Lymphoblastic Lymphoma, also known as precursor cell lymphoblastic leukemia lymphoma, is related to leukemia and acute lymphoblastic leukemia. An important gene associated with Lymphoblastic Lymphoma is PTPRJ (protein tyrosine phosphatase, receptor type, J), and among its related pathways are Cell cycle Regulation of G1 S transition part 1 and Validated targets of C-MYC transcriptional repression. The drugs cyclophosphamide and ifosfamide and the compounds tcdd and probenecid have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and bone, and related mouse phenotypes are integument and normal.

Aliases & Classifications for Lymphoblastic Lymphoma

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Lymphoblastic Lymphoma, Aliases & Descriptions:

Name: Lymphoblastic Lymphoma 30 42
Precursor Cell Lymphoblastic Leukemia Lymphoma 62
 
Lymphoma, Lymphoblastic 42
Lymphoma Lymphoblastic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

ICD1025 C83.5

Related Diseases for Lymphoblastic Lymphoma

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Diseases related to Lymphoblastic Lymphoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 94)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.1DNTT, RAG1, CDKN2B, CTRL
2acute lymphoblastic leukemia31.1CDKN2B, RAG1, DNTT
3burkitt's lymphoma30.7RAG1, DNTT
4myelodysplastic syndromes30.4CDKN2B, DNTT
5precursor t-cell acute lymphoblastic leukemia30.2CDKN2B, RAG1, DNTT
6non-hodgkin lymphoma30.2DNTT, RAG1, CDKN2B
7chronic lymphocytic leukemia30.1CDKN2B, DNTT
8acute leukemia29.9DNTT, RAG1, CDKN2B, CD8A
9lymphoblastic leukemia10.8
10mediastinitis10.7
11precursor b lymphoblastic lymphoma/leukemia10.4
12precursor t-lymphoblastic lymphoma/leukemia10.4
13sarcoma10.4
14multiple myeloma10.4CTRL
15cervicitis10.4
16histiocytosis10.4
17hodgkin's lymphoma10.3
18eosinophilia10.3
19thymoma10.3
20graft versus host disease10.3
21hematopoietic stem cell transplantation10.3
22myasthenia gravis10.3
23precursor t-lymphoblastic lymphoma/leukemia refractory10.3
24childhood precursor t-lymphoblastic lymphoma/leukemia10.3
25malignant histiocytosis10.3
26myeloid leukemia10.3
27precursor lymphoblastic lymphoma/leukemia10.3
28acute biphenotypic leukemia10.2
29acute lymphocytic leukemia10.2
30b-cell lymphomas10.2
31diffuse large b-cell lymphoma10.2
32follicular lymphoma10.2
33langerhans-cell histiocytosis10.2
34intussusception10.2
35thyroiditis10.2
36hypereosinophilic syndrome10.2
37leukemia, acute lymphoblastic 310.2CDKN2B, DNTT
38hematologic cancer10.1DNTT, CDKN2B
39acute myeloid leukemia10.0
40chronic myeloid leukemia10.0
41diabetes mellitus10.0
42juvenile myelomonocytic leukemia10.0
43mantle cell lymphoma10.0
44mycosis fungoides10.0
45myelofibrosis10.0
46obesity10.0
47peripheral t-cell lymphoma10.0
48small non-cleaved cell lymphoma10.0
49type 1 diabetes mellitus10.0
50granulomatous angiitis10.0

Graphical network of the top 20 diseases related to Lymphoblastic Lymphoma:



Diseases related to lymphoblastic lymphoma

Symptoms for Lymphoblastic Lymphoma

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Drugs & Therapeutics for Lymphoblastic Lymphoma

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Drug clinical trials:

Search ClinicalTrials for Lymphoblastic Lymphoma

Search NIH Clinical Center for Lymphoblastic Lymphoma

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphoblastic Lymphoma cell therapies at LifeMap Discovery.

Genetic Tests for Lymphoblastic Lymphoma

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Anatomical Context for Lymphoblastic Lymphoma

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MalaCards organs/tissues related to Lymphoblastic Lymphoma:

32
T cells, B cells, Bone, B lymphoblasts, Bone marrow, Myeloid, Breast, Skin, Thymus, Spinal cord, Kidney, Ovary, Thyroid, Uterus, Eye, Lymph node, Spleen, Heart, Small intestine, Colon, Liver, Nk cells, Tongue, Pituitary

Animal Models for Lymphoblastic Lymphoma or affiliated genes

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MGI Mouse Phenotypes related to Lymphoblastic Lymphoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.1ASCL1, RAG1, CDKN2B, CD8A
2MP:00028737.8CD8A, RAG1, DNTT, ASCL1, PTPRJ
3MP:00053977.6DNTT, RAG1, CDKN2B, CD8A, PTPRJ
4MP:00053877.4CDKN2B, RAG1, DNTT, PTPRJ, CD8A

Publications for Lymphoblastic Lymphoma

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Articles related to Lymphoblastic Lymphoma:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Molecular identification of a TPR-FGFR1 fusion transcript in an adult with myeloproliferative neoplasm, T-lymphoblastic lymphoma, and a t(1;8)(q25;p11.2). (25037443)
2014
2
Sudden extramedullary blast crisis of chronic myeloid leukemia manifesting as T-cell lymphoblastic lymphoma. (23486000)
2013
3
Isolated primary testicular B lymphoblastic lymphoma: an unusual presentation. (23042023)
2013
4
Down-regulation of specific miRNAs enhances the expression of the gene Smoothened and contributes to T-cell lymphoblastic lymphoma development. (23288923)
2013
5
Cutaneous B-cell lymphoblastic lymphoma in children: a rare diagnosis. (21745698)
2012
6
Acute kidney injury and bilateral symmetrical enlargement of the kidneys as first presentation of B-cell lymphoblastic lymphoma. (22835902)
2012
7
Primary cutaneous precursor B-cell lymphoblastic lymphoma with late dissemination. (22159948)
2011
8
Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children's Oncology Group (POG 9404). (21474675)
2011
9
Primary precursor B cell lymphoblastic lymphoma of uterine corpus: case report and review of the literature. (21193918)
2011
10
8p11 Myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: a case report and review of the literature. (21239058)
2011
11
Modulation of the Fas-apoptosis-signalling pathway by functional polymorphisms at Fas, FasL and Fadd and their implication in T-cell lymphoblastic lymphoma susceptibility. (20889682)
2010
12
Nelarabine for the treatment of patients with relapsed or refractory T-cell acute lymphoblastic leukemia or lymphoblastic lymphoma. (19825456)
2009
13
T-cell lymphoblastic lymphoma and T-cell acute lymphoblastic leukemia: a separate entity? (19778844)
2009
14
Bone marrow minimal disseminated disease (MDD) and minimal residual disease (MRD) in childhood T-cell lymphoblastic lymphoma stage III, detected by flow cytometry (FC) and real-time quantitative polymerase chain reaction (RQ-PCR). (19006253)
2009
15
Point mutation of the proteasome beta5 subunit gene is an important mechanism of bortezomib resistance in bortezomib-selected variants of Jurkat T cell lymphoblastic lymphoma/leukemia line. (18502982)
2008
16
K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. (18663146)
2008
17
A Stat5b transgene is capable of inducing CD8+ lymphoblastic lymphoma in the absence of normal TCR/MHC signaling. (17890450)
2008
18
Primary cutaneous B-cell lymphoblastic lymphoma. (19171997)
2008
19
Characterization of childhood precursor T-lymphoblastic lymphoma by immunophenotyping and fluorescent in situ hybridization: a report from the Children's Oncology Group. (18618503)
2008
20
Terminal deoxynucleotidyl transferase negative T-cell lymphoblastic lymphoma in aleukemic patient. (18512118)
2008
21
T-cell lymphoblastic lymphoma presenting as an intra-muscular mass. (16445824)
2006
22
An adult case of precursor B cell lymphoblastic lymphoma extending from right neck to upper cervical spinal region]. (16277225)
2005
23
CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features. (16046525)
2005
24
Unusual abdominal tumors, case 3. Primary omental T-cell lymphoblastic lymphoma. (15084627)
2004
25
Fine needle aspiration biopsy of precursor B-cell lymphoblastic lymphoma presenting as a sacral mass. A case report. (15085760)
2004
26
Cutaneous lymphoblastic lymphoma of putative plasmacytoid dendritic cell-precursor origin: two cases. (12008089)
2002
27
Differentiating lymphoblastic lymphoma and Ewing's sarcoma: lymphocyte markers and gene rearrangement. (11706081)
2001
28
Immunoperoxidase detection of CD10 in Precursor T-lymphoblastic lymphoma/leukemia: a clinicopathologic study of 24 cases. (10782151)
2000
29
Friedreich's ataxia and intrathecal chemotherapy in a patient with lymphoblastic lymphoma. (10631473)
1999
30
Lymphoblastic lymphoma expressing CD56 and TdT. (9422326)
1998
31
Lymphoblastic lymphoma of natural killer cell origin, presenting as pancreatic tumour. (9675589)
1998
32
Acute myelogenous leukemia with monosomy 7, inv(3) (q21q26), involving activated EVI 1 gene occurring after a complete remission of lymphoblastic lymphoma: a case report. (9861236)
1998
33
Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. (9227346)
1997
34
Acute tumor lysis syndrome in high grade lymphoblastic lymphoma after a prolonged episode of fever. (8614380)
1996
35
A T cell lymphoblastic lymphoma patient with two malignant cell populations carrying different 9p deletions including the p16INK4 and p15INK4B genes: Clinical response to interferon-alpha therapy in one of the subclones. (8656689)
1996
36
Childhood T-cell lymphoblastic lymphoma--does early resolution of mediastinal mass predict for final outcome? The United Kingdom Children's Cancer Study Group (UKCCSG). (7669589)
1995
37
Human T-cell lymphoblastic lymphoma expressing the T-cell receptor gamma/delta established in immune-deficient (bg/nu/xid) mice. (8381196)
1993
38
Lymphoblastic lymphoma. (8102865)
1993
39
Lineage alteration in precursor B cell acute lymphoblastic leukemia following T cell lymphoblastic lymphoma. (1333557)
1992
40
Lymphoblastic lymphoma with primary splenic involvement and the classic 14;18 translocation. (1756484)
1991
41
Genuine CD7 expression in acute leukemia and lymphoblastic lymphoma. (1701841)
1990
42
Utilization of two different T cell receptors by T cell acute lymphoblastic lymphoma and leukemia. (2099407)
1990
43
Intracytoplasmic localization of CD3 antigen in NKH1+ azurophilic granular T-lymphoblastic lymphoma cells. (2533446)
1989
44
Bone marrow transplantation for adult poor prognosis lymphoblastic lymphoma in first complete remission. (2803982)
1989
45
Improved treatment results for lymphoblastic lymphoma in adolescents and adults using a doxorubicin-based (APO) protocol. (3196243)
1988
46
Extranodal non-T-cell lymphoblastic lymphoma in adults. A report of two cases. (3052024)
1988
47
Treatment of lymphoblastic lymphoma in adults. (3772416)
1986
48
Lymphoblastic lymphoma: an immunophenotype study of 26 cases with comparison to T cell acute lymphoblastic leukemia. (3080041)
1986
49
Pseudonodular T cell lymphoblastic lymphoma. (6333817)
1984
50
Mediastinal mass with acute leukemia. Myeloblastoma masquerading as lymphoblastic lymphoma. (6937159)
1981

Variations for Lymphoblastic Lymphoma

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Expression for genes affiliated with Lymphoblastic Lymphoma

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Expression patterns in normal tissues for genes affiliated with Lymphoblastic Lymphoma

Search GEO for disease gene expression data for Lymphoblastic Lymphoma.

Pathways for genes affiliated with Lymphoblastic Lymphoma

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Pathways related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.5CDKN2B, CDT1
29.4DNTT, CDKN2B
39.3DNTT, CD8A
4
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.1CDKN2B, RAG1
59.0RAG1, CD8A

Compounds for genes affiliated with Lymphoblastic Lymphoma

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Compounds related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1tcdd449.2RAG1, DNTT
2probenecid28 44 61 50 1113.1DNTT, RAG1
3cytidine44 24 1111.0RAG1, DNTT
4retinoic acid44 249.8ASCL1, DNTT, CDKN2B, CTRL
5zinc44 249.8CTRL, RAG1, DNTT
6serine448.4PTPRJ, DNTT, CDKN2B, CTRL
7tyrosine448.4CTRL, CD8A, CDKN2B, ASCL1, PTPRJ

GO Terms for genes affiliated with Lymphoblastic Lymphoma

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Molecular functions related to Lymphoblastic Lymphoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:0199019.0CD8A, CDKN2B, PTPRJ
2protein homodimerization activityGO:0428038.3ASCL1, RAG1, CD8A
3DNA bindingGO:0036778.2CDT1, RAG1, DNTT, ASCL1
4protein bindingGO:0055157.3CD8A, CDKN2B, CDT1, RAG1, ASCL1, PTPRJ

Products for genes affiliated with Lymphoblastic Lymphoma

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Sources for Lymphoblastic Lymphoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet