LCM
MCID: LYM009
MIFTS: 63

Lymphocytic Choriomeningitis (LCM) malady

Infectious diseases, Immune diseases, Neuronal diseases categories
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Summaries for Lymphocytic Choriomeningitis

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Disease Ontology:8 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in lymphocytic choriomeningitis virus, which is transmitted by common house mouse, mus musculus. the infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary: Lymphocytic Choriomeningitis, also known as lymphocytic choriomeningitis virus encephalomyelitis, is related to lassa fever and herpes simplex, and has symptoms including An important gene associated with Lymphocytic Choriomeningitis is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)), and among its related pathways are Inflammatory Response Pathway and Nur77 Signaling in T-Cell. The compounds il-12 and flagellin have been mentioned in the context of this disorder. Affiliated tissues include brain, meninges and t cells, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

CDC:3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia:65 Lymphocytic choriomeningitis (LCM), is a rodent-borne viral infectious disease that presents as aseptic... more...

Aliases & Classifications for Lymphocytic Choriomeningitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 25ICD10
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Lymphocytic Choriomeningitis, Aliases & Descriptions:

Name: Lymphocytic Choriomeningitis 8 10 44 62
Lymphocytic Choriomeningitis Virus Encephalomyelitis 8 62
Lymphocytic Meningoencephalitis 8 62
 
Lymphocytic Meningitis 8
Lcm 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases, Neuronal diseases


External Ids:

Disease Ontology8 DOID:12155
MeSH34 D008216
ICD1025 A87.2

Related Diseases for Lymphocytic Choriomeningitis

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Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to lymphocytic choriomeningitis

Symptoms for Lymphocytic Choriomeningitis

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Drugs & Therapeutics for Lymphocytic Choriomeningitis

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Drug clinical trials:

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Search NIH Clinical Center for Lymphocytic Choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

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Anatomical Context for Lymphocytic Choriomeningitis

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MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

32
T cells, Brain, Spleen, B cells, Liver, Bone marrow, Bone, Monocytes, Nk cells, Kidney, Lung, Thyroid, Testes, Endothelial, Neutrophil

FMA organs/tissues related to Lymphocytic Choriomeningitis:

14
Brain, Meninges

Animal Models for Lymphocytic Choriomeningitis or affiliated genes

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MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0MYD88, ADAR, IL7, KRT1, CD86, CD80
2MP:00053797.7GP2, TMPO, MYD88, CA9, CD86, CD80
3MP:00053877.3CD80, MYD88, IRF9, IRF3, ADAR, IL7
4MP:00053847.0DAG1, TMPO, MYD88, IRF3, ADAR, GLRX3

Publications for Lymphocytic Choriomeningitis

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Articles related to Lymphocytic Choriomeningitis:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro. (24155390)
2014
2
Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice. (22674984)
2012
3
Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function. (22258244)
2012
4
Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. (22889536)
2012
5
Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. (21098292)
2010
6
Lymphocytic choriomeningitis virus meningitis, New York, NY, USA, 2009. (20113573)
2010
7
The alternative NF-kappaB signalling pathway is a prerequisite for an appropriate immune response against lymphocytic choriomeningitis virus infection. (20565293)
2010
8
Lymphocytic choriomeningitis virus: a prenatal and postnatal threat. (19968943)
2009
9
Lymphocytic choriomeningitis virus uses a novel endocytic pathway for infectious entry via late endosomes. (18554681)
2008
10
A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses. (17686978)
2007
11
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought. (17151096)
2007
12
Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat. (18052527)
2007
13
Survey of lymphocytic choriomeningitis virus diagnosis and testing--Connecticut, 2005. (16617288)
2006
14
Congenital lymphocytic choriomeningitis virus: an underdiagnosed cause of neonatal hydrocephalus. (16732159)
2006
15
Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection. (16920967)
2006
16
CNS activity of Pokeweed anti-viral protein (PAP) in mice infected with lymphocytic choriomeningitis virus (LCMV). (15725345)
2005
17
Urolithiasis associated with experimental lymphocytic choriomeningitis virus inoculation in Lewis rats. (15253279)
2004
18
Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P. (12584310)
2003
19
Detection of lymphocytic choriomeningitis virus by use of fluorogenic nuclease reverse transcriptase-polymerase chain reaction analysis. (12625508)
2003
20
Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice. (12504535)
2003
21
Role of the virus nucleoprotein in the regulation of lymphocytic choriomeningitis virus transcription and RNA replication. (12610166)
2003
22
Identification of the lymphocytic choriomeningitis virus (LCMV) proteins required to rescue LCMV RNA analogs into LCMV-like particles. (12021374)
2002
23
CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells. (12097371)
2002
24
NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs. (10729120)
2000
25
Retroviral vectors pseudotyped with lymphocytic choriomeningitis virus. (10364368)
1999
26
Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. (10580062)
1999
27
Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. (9499083)
1998
28
Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection. (9164957)
1997
29
Lymphocytic choriomeningitis virus: a new addition to the TORCH evaluation. (9152144)
1997
30
Congenital lymphocytic choriomeningitis virus infection. (8634744)
1996
31
T-cell-mediated immunity to lymphocytic choriomeningitis virus in beta2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice. (8971031)
1996
32
Lymphocytic choriomeningitis virus: a neglected central nervous system pathogen. (8825010)
1996
33
Murine hepatitis caused by lymphocytic choriomeningitis virus. II. Cells involved in pathogenesis. (7745950)
1995
34
Concurrent sequence analysis of 5' and 3' RNA termini by intramolecular circularization reveals 5' nontemplated bases and 3' terminal heterogeneity for lymphocytic choriomeningitis virus mRNAs. (7682625)
1993
35
Replication of lymphocytic choriomeningitis virus is restricted in terminally differentiated neurons. (8230458)
1993
36
Altered cytokine genes expression by conA-activated spleen cells from mice infected by lymphocytic choriomeningitis virus. (7685735)
1993
37
Immunosuppression in mice by lymphocytic choriomeningitis virus infection: time dependence during primary and absence of effects on secondary antibody responses. (2170031)
1990
38
Infection of guinea pigs with two strains of lymphocytic choriomeningitis virus. (2130208)
1990
39
IFN-gamma production in tissues of mice during acute infection with lymphocytic choriomeningitis virus. (2109012)
1990
40
In vivo selection of lymphocyte-tropic and macrophage-tropic variants of lymphocytic choriomeningitis virus during persistent infection. (1976825)
1990
41
Perturbation of differentiated functions during viral infection in vivo. In vivo relationship of host genes and lymphocytic choriomeningitis virus to growth hormone deficiency. (2221020)
1990
42
Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo. (2514255)
1989
43
An acquired immune suppression in mice caused by infection with lymphocytic choriomeningitis virus. (2452742)
1988
44
State of viral genome and proteins during persistent lymphocytic choriomeningitis virus infection. (2435462)
1987
45
Lack of correlation between serum titres of interferon alpha, beta, natural killer cell activity and clinical susceptibility in mice infected with two isolates of lymphocytic choriomeningitis virus. (3612089)
1987
46
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. VI. Migration and activity in vivo in acute and persistent infection. (2416821)
1986
47
Immunosuppression in experimental trypanosomiasis: effects of Trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. (232108)
1979
48
Pathogenesis of cerebellar hypoplasia produced by lymphocytic choriomeningitis virus infection of neonatal rats. 1. Evolution of disease following infection at 4 days of age. (4568304)
1973
49
Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. (4561841)
1972
50
Cerebellar hypoplasia in neonatal rats caused by lymphocytic choriomeningitis virus. (4992415)
1971

Variations for Lymphocytic Choriomeningitis

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Expression for genes affiliated with Lymphocytic Choriomeningitis

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Expression patterns in normal tissues for genes affiliated with Lymphocytic Choriomeningitis

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Pathways for genes affiliated with Lymphocytic Choriomeningitis

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Pathways related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD80, CD86
29.4CD86, CD80
3
Show member pathways
9.3MYD88, ADAR, IRF3
4
Show member pathways
9.2IRF9, IRF3, ADAR
5
Show member pathways
9.1CD80, DAG1, CD86
6
Show member pathways
8.9ADAR, MYD88, IRF9, IRF3
7
Show member pathways
8.7ADAR, IL7, MYD88, IRF3, IRF9
8
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5MYD88, IRF3, CD86, CD80

Compounds for genes affiliated with Lymphocytic Choriomeningitis

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Compounds related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1il-124410.1CD86, IL7
2flagellin44 2811.0CD86, MYD88
32,5-oligoadenylate449.8ADAR, IRF9
4nicotine44 28 50 1112.7TMPO, FMO3, KRT1
5belatacept44 1110.7CD86, CD80
6abatacept44 1110.7CD86, CD80
71-chloro-24-dinitrobenzene449.6CD80, CD86
8inosine44 2410.5ADAR, TMPO
9endotoxin449.5CD86, IRF3, MYD88
10ctla4-ig449.5IL7, CD86, CD80
11allergens449.4CD80, CD86, IL7
12dextran449.4CD80, CD86
13rantes449.3IL7, IRF3, MYD88
14cyclosporin a44 28 6111.0CD80, CD86, IL7, TMPO
15pge2449.0TMPO, IL7, CD86, CD80
16rapamycin448.9IL7, CA9, CD86, CD80
17lipid448.9GP2, MYD88, IRF3, IL7, KRT1
18nitric oxide44 24 1110.8TMPO, MYD88, IL7, CD86, CD80
19proline448.7CD80, KRT1, CA9, IL7, MYD88
20oxygen44 249.6MYD88, IL7, CA9, FMO3, CD80
21cycloheximide448.4IRF9, IRF3, IL7, CD86, CD80
22calcium44 50 24 1110.4DAG1, TMBIM4, TMPO, IL7, CA9, GLRX3
23tyrosine447.1CD80, TMPO, MYD88, IRF9, IRF3, IL7

GO Terms for genes affiliated with Lymphocytic Choriomeningitis

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Biological processes related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1type I interferon biosynthetic processGO:0453519.6IRF3, IRF9
2positive regulation of interleukin-2 biosynthetic processGO:0450869.5CD80, CD86
3toll-like receptor signaling pathwayGO:0022249.4MYD88, IRF3, CD86
4type I interferon signaling pathwayGO:0603379.3ADAR, IRF3, IRF9
5negative regulation of apoptotic processGO:0430669.3IL7, ADAR, MYD88, TMBIM4
6cytokine-mediated signaling pathwayGO:0192219.2IRF9, IRF3, ADAR
7neurotrophin TRK receptor signaling pathwayGO:0480119.1CD80, CD86, MYD88
8defense response to virusGO:0516079.1IRF9, IRF3, ADAR, CD86
9T cell activationGO:0421109.1CD80, CD86
10cell-cell signalingGO:0072679.0CD80, CD86, IL7
11innate immune responseGO:0450878.1TRIM31, CD80, CD86, ADAR, IRF3, MYD88

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:0150269.4CD80, CD86
2protein bindingGO:0055155.5CD80, DAG1, TMBIM4, TMPO, MYD88, IRF9

Products for genes affiliated with Lymphocytic Choriomeningitis

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Sources for Lymphocytic Choriomeningitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet