MCID: LYM009
MIFTS: 46

Lymphocytic Choriomeningitis

Categories: Infectious diseases, Immune diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 51 3 41 14 69
Lcm 12 3
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 69
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
ICD10 32 A87.2
ICD9CM 34 049.0
MeSH 41 D008216

Summaries for Lymphocytic Choriomeningitis

Disease Ontology : 12 A viral infectious disease that results_in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lcm, is related to lassa fever and mollaret meningitis, and has symptoms including fever, lack of appetite and headache. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1). Affiliated tissues include brain, meninges and brain, and related phenotypes are Decreased vesicular stomatitis virus (VSV) infection and Decreased vesicular stomatitis virus (VSV) infection

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia : 72 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 lassa fever 29.9 AXL DAG1
2 mollaret meningitis 11.0
3 allergic hypersensitivity disease 10.2
4 meningitis 10.1
5 hepatitis 10.1
6 central nervous system disease 10.1
7 nervous system disease 10.1
8 neuronitis 10.1
9 influenza 10.1
10 growth hormone deficiency 10.1
11 cerebellar hypoplasia 10.0
12 aging 10.0
13 chorioretinitis 10.0
14 blood group, i system 10.0
15 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
16 hydrocephalus 10.0
17 meningoencephalitis 10.0
18 stomatitis 10.0
19 la crosse encephalitis 9.9 AXL TYRO3
20 leukemia 9.9
21 mucositis 9.9
22 mumps 9.9
23 parotitis 9.9
24 orchitis 9.9
25 vaccinia 9.9
26 encephalitis 9.9
27 toxoplasmosis 9.9
28 glioma 9.9
29 hemorrhagic fever 9.9
30 cytomegalovirus infection 9.9
31 multiple sclerosis 9.7
32 immune suppression 9.7
33 keratitis, hereditary 9.7
34 anemia, autoimmune hemolytic 9.7
35 surfactant metabolism dysfunction, pulmonary, 1 9.7
36 body mass index quantitative trait locus 11 9.7
37 surfactant metabolism dysfunction, pulmonary, 4 9.7
38 body mass index quantitative trait locus 9 9.7
39 body mass index quantitative trait locus 8 9.7
40 body mass index quantitative trait locus 4 9.7
41 body mass index quantitative trait locus 10 9.7
42 body mass index quantitative trait locus 7 9.7
43 aplastic anemia 9.7
44 surfactant metabolism dysfunction, pulmonary, 3 9.7
45 body mass index quantitative trait locus 12 9.7
46 body mass index quantitative trait locus 14 9.7
47 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.7
48 body mass index quantitative trait locus 18 9.7
49 hydrops, lactic acidosis, and sideroblastic anemia 9.7
50 hydrops fetalis, nonimmune, and/or atrial septal defect 9.7

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

Symptoms:

12
  • fever
  • lack of appetite
  • headache
  • muscle aches
  • malaise
  • nausea
  • vomiting

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 10.03 ATP6AP2 MAT2A ATP6V0B CARD14 COPA H1FOO
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 10.03 ATP6AP2 MAT2A ATP6V0B CARD14 COPA H1FOO
3 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.73 MAT2A ATP6V0B CARD14 COPA H1FOO ATP6AP2
4 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.5 MAT2A COPA H1FOO
5 Decreased Salmonella-containing vacuole maturation GR00133-A-2 9.33 ATP6AP2 TYRO3 COPA
6 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.92 TYRO3 AXL COPA H1FOO

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Search Clinical Trials , NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphocytic Choriomeningitis:

18
Brain, Meninges, Brain

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

38
T Cells, Brain, Spleen, B Cells, Liver, Monocytes, Nk Cells

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 563)
# Title Authors Year
1
Seroprevalence of lymphocytic choriomeningitis virus and Ljungan virus in Finnish patients with suspected neurological infections. ( 28976562 )
2018
2
Osteoblasts Are Rapidly Ablated by Virus-Induced Systemic Inflammation following Lymphocytic Choriomeningitis Virus or Pneumonia Virus of Mice Infection in Mice. ( 29212906 )
2018
3
CD30 Is Dispensable for T-Cell Responses to Influenza Virus and Lymphocytic Choriomeningitis Virus Clone 13 but Contributes to Age-Associated T-Cell Expansion in Mice. ( 28993768 )
2017
4
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein. ( 29261807 )
2017
5
Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. ( 28214859 )
2017
6
Semi-Functional Quantitative Flow Cytometry Assay for Lymphocytic Choriomeningitis Virus Titration. ( 29093652 )
2017
7
Congenital Lymphocytic Choriomeningitis Virus: A Case of Prenatal Diagnosis. ( 28858375 )
2017
8
Resistance of human plasmacytoid dendritic CAL-1 cells to infection with lymphocytic choriomeningitis virus (LCMV) is caused by restricted virus cell entry, which is overcome by contact of CAL-1 cells with LCMV-infected cells. ( 28843812 )
2017
9
IRF9 Prevents CD8<sup>+</sup>T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. ( 28878077 )
2017
10
Microcephaly Caused by Lymphocytic Choriomeningitis Virus. ( 28820372 )
2017
11
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
12
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. ( 27899229 )
2017
13
Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. ( 28949905 )
2017
14
High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus. ( 28423464 )
2017
15
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. ( 28747914 )
2017
16
Congenital lymphocytic choriomeningitis virus-an underdiagnosed fetal teratogen. ( 29274373 )
2017
17
Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection. ( 27721109 )
2016
18
T-Cells Underlie Some but Not All of the Cerebellar Pathology in a Neonatal Rat Model of Congenital Lymphocytic Choriomeningitis Virus Infection. ( 27667772 )
2016
19
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. ( 27076310 )
2016
20
The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. ( 27010636 )
2016
21
Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015. ( 26963688 )
2016
22
Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus. ( 27265463 )
2016
23
Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection. ( 26973071 )
2016
24
Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice. ( 27581982 )
2016
25
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice. ( 27404802 )
2016
26
Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection. ( 26982463 )
2016
27
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection. ( 27549169 )
2016
28
Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana. ( 26631809 )
2016
29
Maternal onset de novo SH2D1A mutation and lymphocytic choriomeningitis virus infection in a patient with Xa89linked lymphoproliferative disease type 1: a case report. ( 25572984 )
2015
30
Peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis. ( 26319106 )
2015
31
Lymphocytic choriomeningitis virus differentially affects virus-induced type I IFN response and mitochondrial apoptosis mediated by RIG-I/MAVS. ( 25833049 )
2015
32
Antiviral Effect of Interferon Lambda Against Lymphocytic Choriomeningitis Virus. ( 25830339 )
2015
33
The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity. ( 26355095 )
2015
34
Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. ( 26290604 )
2015
35
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain. ( 26423945 )
2015
36
Lymphocytic choriomeningitis and alpha-chemokines. ( 26152632 )
2015
37
Lymphocytic choriomeningitis virus infection induced by percutaneous exposure. ( 26416845 )
2015
38
Protracted Symptoms in Lymphocytic Choriomeningitis: A Case Report. ( 24736119 )
2014
39
Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses. ( 25015511 )
2014
40
Lymphocytic choriomeningitis virus in employees and mice at multipremises feeder-rodent operation, United States, 2012. ( 24447605 )
2014
41
Evidence of lymphocytic choriomeningitis virus in domestic mice in Gabon; risk of emergence of LCMV encephalitis in Central Africa. ( 25378495 )
2014
42
Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness. ( 24829355 )
2014
43
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation-Iowa, 2013. ( 24854024 )
2014
44
IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. ( 24760883 )
2014
45
Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution. ( 25395301 )
2014
46
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro. ( 24155390 )
2014
47
Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes. ( 24928036 )
2014
48
Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC. ( 25281716 )
2014
49
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation - Iowa, 2013. ( 24647402 )
2014
50
Pseudotyping lentiviral vectors with lymphocytic choriomeningitis virus glycoproteins for transduction of dendritic cells and in vivo immunization. ( 25416034 )
2014

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

GO Terms for Lymphocytic Choriomeningitis

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.78 AXL CARD14 DDX3X MYD88
2 viral process GO:0016032 9.65 AXL CLEC4G DAG1 DDX3X TYRO3
3 protein kinase B signaling GO:0043491 9.51 AXL TYRO3
4 substrate adhesion-dependent cell spreading GO:0034446 9.49 AXL TYRO3
5 apoptotic cell clearance GO:0043277 9.46 AXL TYRO3
6 secretion by cell GO:0032940 9.43 AXL TYRO3
7 vagina development GO:0060068 9.4 AXL TYRO3
8 natural killer cell differentiation GO:0001779 9.37 AXL TYRO3
9 ovulation cycle GO:0042698 9.32 AXL TYRO3
10 forebrain cell migration GO:0021885 9.16 AXL TYRO3
11 negative regulation of lymphocyte activation GO:0051250 8.96 AXL TYRO3
12 viral entry into host cell GO:0046718 8.92 AXL CLEC4G DAG1 TYRO3

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 AXL TYRO3
2 phosphatidylinositol 3-kinase binding GO:0043548 8.96 AXL TYRO3
3 virus receptor activity GO:0001618 8.92 AXL CLEC4G DAG1 TYRO3

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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