LCM
MCID: LYM009
MIFTS: 63

Lymphocytic Choriomeningitis (LCM) malady

Infectious diseases, Immune diseases, Neuronal diseases categories
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Summaries for Lymphocytic Choriomeningitis

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8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in lymphocytic choriomeningitis virus, which is transmitted by common house mouse, mus musculus. the infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards: Lymphocytic Choriomeningitis, also known as lymphocytic choriomeningitis virus encephalomyelitis, is related to lassa fever and influenza, and has symptoms including headache, nausea and vomiting. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)), and among its related pathways are Inflammatory Response Pathway and Nur77 Signaling in T-Cell. The compounds il-12 and flagellin have been mentioned in the context of this disorder. Affiliated tissues include brain, meninges and t cells, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

CDC:4 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia:65 Lymphocytic choriomeningitis (LCM), is a rodent-borne viral infectious disease that presents as aseptic... more...

Aliases & Classifications for Lymphocytic Choriomeningitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases, Neuronal diseases


Aliases & Descriptions:

lymphocytic choriomeningitis 8 10 45 62
lymphocytic choriomeningitis virus encephalomyelitis 8
lymphocytic meningoencephalitis 8
lymphocytic meningitis 8
lcm 8


External Ids:

Disease Ontology8 DOID:12155
MeSH35 D008216
ICD1025 A87.2

Related Diseases for Lymphocytic Choriomeningitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to lymphocytic choriomeningitis

Symptoms for Lymphocytic Choriomeningitis

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8Disease Ontology
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Symptoms:

8 (show all 7)
  • headache
  • nausea
  • vomiting
  • malaise
  • muscle aches
  • lack of appetite
  • fever

Drugs & Therapeutics for Lymphocytic Choriomeningitis

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lymphocytic Choriomeningitis

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

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Anatomical Context for Lymphocytic Choriomeningitis

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

33
T cells, Brain, Spleen, B cells, Liver, Bone, Bone marrow, Monocytes, Nk cells, Thyroid, Testes, Lung, Kidney, Endothelial

FMA organs/tissues related to Lymphocytic Choriomeningitis:

14
Brain, Meninges

Animal Models for Lymphocytic Choriomeningitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.0MYD88, ADAR, IL7, KRT1, CD86, CD80
2MP:00053797.7GP2, TMPO, MYD88, CA9, CD86, CD80
3MP:00053877.3CD80, MYD88, IRF9, IRF3, ADAR, IL7
4MP:00053847.0DAG1, TMPO, MYD88, IRF3, ADAR, GLRX3

Publications for Lymphocytic Choriomeningitis

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52PubMed
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Articles related to Lymphocytic Choriomeningitis:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro. (24155390)
2014
2
Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice. (22674984)
2012
3
Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function. (22258244)
2012
4
Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. (22889536)
2012
5
Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. (21098292)
2010
6
The alternative NF-kappaB signalling pathway is a prerequisite for an appropriate immune response against lymphocytic choriomeningitis virus infection. (20565293)
2010
7
Lymphocytic choriomeningitis virus: a prenatal and postnatal threat. (19968943)
2009
8
Lymphocytic choriomeningitis virus uses a novel endocytic pathway for infectious entry via late endosomes. (18554681)
2008
9
A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses. (17686978)
2007
10
Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: it is even bigger than we thought. (17151096)
2007
11
Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat. (18052527)
2007
12
Survey of lymphocytic choriomeningitis virus diagnosis and testing--Connecticut, 2005. (16617288)
2006
13
Congenital lymphocytic choriomeningitis virus: an underdiagnosed cause of neonatal hydrocephalus. (16732159)
2006
14
Type 1 IFN deficiency in the absence of normal splenic architecture during lymphocytic choriomeningitis virus infection. (16920967)
2006
15
CNS activity of Pokeweed anti-viral protein (PAP) in mice infected with lymphocytic choriomeningitis virus (LCMV). (15725345)
2005
16
Urolithiasis associated with experimental lymphocytic choriomeningitis virus inoculation in Lewis rats. (15253279)
2004
17
Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P. (12584310)
2003
18
Detection of lymphocytic choriomeningitis virus by use of fluorogenic nuclease reverse transcriptase-polymerase chain reaction analysis. (12625508)
2003
19
Control of lymphocytic choriomeningitis virus infection in granzyme B deficient mice. (12504535)
2003
20
Role of the virus nucleoprotein in the regulation of lymphocytic choriomeningitis virus transcription and RNA replication. (12610166)
2003
21
Identification of the lymphocytic choriomeningitis virus (LCMV) proteins required to rescue LCMV RNA analogs into LCMV-like particles. (12021374)
2002
22
CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells. (12097371)
2002
23
NP and L proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs. (10729120)
2000
24
Retroviral vectors pseudotyped with lymphocytic choriomeningitis virus. (10364368)
1999
25
Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. (10580062)
1999
26
Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. (9499083)
1998
27
Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection. (9164957)
1997
28
Lymphocytic choriomeningitis virus: a new addition to the TORCH evaluation. (9152144)
1997
29
Congenital lymphocytic choriomeningitis virus infection. (8634744)
1996
30
T-cell-mediated immunity to lymphocytic choriomeningitis virus in beta2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice. (8971031)
1996
31
Lymphocytic choriomeningitis virus: a neglected central nervous system pathogen. (8825010)
1996
32
Murine hepatitis caused by lymphocytic choriomeningitis virus. II. Cells involved in pathogenesis. (7745950)
1995
33
Protection against lethal lymphocytic choriomeningitis virus (LCMV) infection by immunization of mice with an influenza virus containing an LCMV epitope recognized by cytotoxic T lymphocytes. (7514676)
1994
34
Concurrent sequence analysis of 5' and 3' RNA termini by intramolecular circularization reveals 5' nontemplated bases and 3' terminal heterogeneity for lymphocytic choriomeningitis virus mRNAs. (7682625)
1993
35
Replication of lymphocytic choriomeningitis virus is restricted in terminally differentiated neurons. (8230458)
1993
36
Altered cytokine genes expression by conA-activated spleen cells from mice infected by lymphocytic choriomeningitis virus. (7685735)
1993
37
Immunosuppression in mice by lymphocytic choriomeningitis virus infection: time dependence during primary and absence of effects on secondary antibody responses. (2170031)
1990
38
IFN-gamma production in tissues of mice during acute infection with lymphocytic choriomeningitis virus. (2109012)
1990
39
In vivo selection of lymphocyte-tropic and macrophage-tropic variants of lymphocytic choriomeningitis virus during persistent infection. (1976825)
1990
40
Perturbation of differentiated functions during viral infection in vivo. In vivo relationship of host genes and lymphocytic choriomeningitis virus to growth hormone deficiency. (2221020)
1990
41
Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo. (2514255)
1989
42
An acquired immune suppression in mice caused by infection with lymphocytic choriomeningitis virus. (2452742)
1988
43
State of viral genome and proteins during persistent lymphocytic choriomeningitis virus infection. (2435462)
1987
44
Lack of correlation between serum titres of interferon alpha, beta, natural killer cell activity and clinical susceptibility in mice infected with two isolates of lymphocytic choriomeningitis virus. (3612089)
1987
45
Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. VI. Migration and activity in vivo in acute and persistent infection. (2416821)
1986
46
Immunosuppression in experimental trypanosomiasis: effects of Trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. (232108)
1979
47
Pathogenesis of cerebellar hypoplasia produced by lymphocytic choriomeningitis virus infection of neonatal rats. 1. Evolution of disease following infection at 4 days of age. (4568304)
1973
48
Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. (4561841)
1972
49
Cerebellar hypoplasia in neonatal rats caused by lymphocytic choriomeningitis virus. (4992415)
1971
50
The demonstration of substances in human sera which inhibit complement fixation in antigen-antibody systems of lymphogranuloma venereum, psittacosis, mumps, Q fever, and lymphocytic choriomeningitis. (13295197)
1956

Variations for Lymphocytic Choriomeningitis

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Expression for genes affiliated with Lymphocytic Choriomeningitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for genes affiliated with Lymphocytic Choriomeningitis

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50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 30KEGG, 60Thomson Reuters
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Pathways related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CD80, CD86
29.4CD86, CD80
3
Show member pathways
9.3MYD88, ADAR, IRF3
4
Show member pathways
9.2IRF9, IRF3, ADAR
5
Show member pathways
9.1CD80, DAG1, CD86
6
Show member pathways
8.9ADAR, MYD88, IRF9, IRF3
7
Show member pathways
8.7ADAR, IL7, MYD88, IRF3, IRF9
8
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5MYD88, IRF3, CD86, CD80

Compounds for genes affiliated with Lymphocytic Choriomeningitis

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience
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Compounds related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1il-124510.1CD86, IL7
2flagellin45 2911.0CD86, MYD88
32,5-oligoadenylate459.8ADAR, IRF9
4nicotine45 29 51 1112.7TMPO, FMO3, KRT1
5belatacept45 1110.7CD86, CD80
6abatacept45 1110.7CD86, CD80
71-chloro-24-dinitrobenzene459.6CD80, CD86
8inosine45 2410.5ADAR, TMPO
9endotoxin459.5CD86, IRF3, MYD88
10ctla4-ig459.5IL7, CD86, CD80
11allergens459.4CD80, CD86, IL7
12dextran459.4CD80, CD86
13rantes459.3IL7, IRF3, MYD88
14cyclosporin a45 29 6111.0CD80, CD86, IL7, TMPO
15pge2459.0TMPO, IL7, CD86, CD80
16rapamycin458.9IL7, CA9, CD86, CD80
17lipid458.9GP2, MYD88, IRF3, IL7, KRT1
18nitric oxide45 24 1110.8TMPO, MYD88, IL7, CD86, CD80
19proline458.7CD80, KRT1, CA9, IL7, MYD88
20oxygen45 249.6MYD88, IL7, CA9, FMO3, CD80
21cycloheximide458.4IRF9, IRF3, IL7, CD86, CD80
22calcium45 51 24 1110.4DAG1, TMBIM4, TMPO, IL7, CA9, GLRX3
23tyrosine457.1CD80, TMPO, MYD88, IRF9, IRF3, IL7

GO Terms for genes affiliated with Lymphocytic Choriomeningitis

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16Gene Ontology
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Biological processes related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1type I interferon biosynthetic processGO:0453519.6IRF3, IRF9
2positive regulation of interleukin-2 biosynthetic processGO:0450869.5CD80, CD86
3toll-like receptor signaling pathwayGO:0022249.4MYD88, IRF3, CD86
4type I interferon signaling pathwayGO:0603379.3ADAR, IRF3, IRF9
5negative regulation of apoptotic processGO:0430669.3IL7, ADAR, MYD88, TMBIM4
6cytokine-mediated signaling pathwayGO:0192219.2IRF9, IRF3, ADAR
7neurotrophin TRK receptor signaling pathwayGO:0480119.1CD80, CD86, MYD88
8defense response to virusGO:0516079.1IRF9, IRF3, ADAR, CD86
9T cell activationGO:0421109.1CD80, CD86
10cell-cell signalingGO:0072679.0CD80, CD86, IL7
11innate immune responseGO:0450878.1TRIM31, CD80, CD86, ADAR, IRF3, MYD88

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1coreceptor activityGO:0150269.4CD80, CD86
2protein bindingGO:0055155.5CD80, DAG1, TMBIM4, TMPO, MYD88, IRF9

Products for genes affiliated with Lymphocytic Choriomeningitis

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Sources for Lymphocytic Choriomeningitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet