Lymphocytic Choriomeningitis malady

Disease Ontology: A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in lymphocytic choriomeningitis virus, which is transmitted by common house mouse, mus musculus. the infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.⁶

MalaCards: Lymphocytic Choriomeningitis, also known as lymphocytic choriomeningitis virus encephalomyelitis (disorder), is related to lassa fever and argentine hemorrhagic fever, and has symptoms including fever, lack of appetite and headache. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)), and among its related pathways are Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways and Primary immunodeficiency. The compounds ionomycin and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, brain and meninges, and related mouse phenotypes are hematopoietic system and digestive/alimentary.

Wikipedia: Lymphocytic choriomeningitis (LCM), is a rodent-borne viral infectious disease that presents as aseptic...⁴⁴ more...

Aliases & Descriptions:

lymphocytic choriomeningitis 6 8 32 43 lymphocytic choriomeningitis virus encephalomyelitis (disorder) 6 lymphocytic meningoencephalitis (disorder) 6

lymphocytic meningitis (disorder) 6 lcm 6

Diseases related to lymphocytic choriomeningitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 271)

id	Related Disease	Score	Top Affiliating Genes
1	lassa fever	28.7	GTPBP1, MBTPS1, GP2, IFNG, TMBIM4, DAG1
2	argentine hemorrhagic fever	13.6	GP2, TMBIM4
3	primary immunodeficiency disease	13.0	CD8A, CD4, CD40
4	chickenpox	12.9	CD8A, CD4, GYPC
5	oral tuberculosis	12.8	IL2, TNF
6	hepatitis d	12.8	IFNA1, TNF, DAG1
7	panuveitis	12.8	IFNA1, TNF
8	hand, foot and mouth disease	12.8	CD4, IRF3, IFNA1
9	tuberculous uveitis	12.6	IFNG, TNF
10	alveolar echinococcosis	12.5	CD8A, IFNG, TNF
11	progressive multifocal leukoencephalopathy	12.4	CD4, IL2, TNF
12	mucocutaneous leishmaniasis	12.4	IFNG, TNF
13	hairy cell leukemia	12.4	CD40, IL2, IFNA1
14	cardiac sarcoidosis	12.4	IFNG, TNF, PSMB8
15	hodgkin's lymphoma	12.4	CD40, IL2, IL7, TMPO
16	panniculitis	12.3	IFNG, TNF, PSMB8
17	kidney cancer	12.3	IL2, IFNA1, CA9
18	endophthalmitis	12.3	IFNG, TNF, PRF1
19	mycobacterium avium complex disease	12.3	CD4, IFNG, TNF
20	keratitis	12.3	MYD88, CD4, IFNA1, TNF
21	multifocal motor neuropathy	12.3	IL2, IFNG
22	orchitis	12.3	CD4, IFNG, TNF
23	echinococcosis	12.3	CD8A, IFNG, TNF
24	pleural tuberculosis	12.3	IFNG, TNF
25	adult t-cell leukemia	12.3	CD8A, CD4, CD40, IL2, IL7
26	rheumatoid arthritis	12.3	CD40, IL2, TNF
27	chronic lymphocytic leukemia	12.3	CD4, CD40, IL2, IL7
28	cryptococcosis	12.3	CD4, IFNG, TNF
29	histoplasmosis	12.3	CD4, IFNG, TNF
30	aids dementia complex	12.2	CD4, IFNG, TNF
31	polyradiculoneuropathy	12.2	IL2, IFNG, PRF1
32	autoimmune thyroiditis	12.2	CD40, IFNG, PSMB8
33	opportunistic bacterial infectious disease	12.2	CD4, IL7, IFNG, TNF
34	lepromatous leprosy	12.2	IL2, IFNG
35	synovitis	12.2	CD4, IL2, IL7, TNF
36	posterior uveitis	12.2	IFNA1, IFNG, TNF
37	mumps	12.1	CD4, IRF9, IFNG, TNF
38	paracoccidioidomycosis	12.1	MYD88, CD4, IFNG, TNF
39	berylliosis	12.1	IL2, IFNG
40	glucocorticoid resistance	12.1	IL2, IFNA1, TNF
41	contact dermatitis	12.1	CD4, IL7, IFNG, TNF
42	newcastle disease	12.1	IRF3, IL2, IFNA1, TNF
43	agammaglobulinemia	12.1	CD4, CD40, IL2, TNF
44	commensal bacterial infectious disease	12.1	MYD88, IRF3, IFNG, TNF
45	pulmonary plasma cell granuloma	12.1	CD4, IFNG, TNF
46	avian influenza	12.1	IFNA1, IFNG, TNF
47	cytomegalovirus retinitis	12.1	IL2, IFNG, TNF
48	multidrug-resistant tuberculosis	12.0	IL2, IFNG, TNF
49	coccidiosis	12.0	CD8A, CD4, IL2, IFNG
50	periapical granuloma	12.0	IL2, IFNG, TNF

Symptoms: fever, lack of appetite, headache, muscle aches, malaise, nausea, vomiting.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to lymphocytic choriomeningitis:

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FMA organs/tissues related to lymphocytic choriomeningitis:

¹¹

MGI Mouse Phenotypes related to lymphocytic choriomeningitis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.1	ADAR, PSMB8, PSMB10, TMPO, CD8A, USP18
2	digestive/alimentary phenotype	MP:0005381	8.7	CD4, MBTPS1, IFNG, CA9, TMPO
3	immune system phenotype	MP:0005387	7.7	MYD88, TNF, IFNG, MBTPS1, IL2, IRF9
4	homeostasis/metabolism phenotype	MP:0005376	7.6	ADAR, PRF1, KRT1, DAG1, GLRX3, MBTPS1
5	mortality/aging	MP:0010768	5.7	GLRX3, TNF, DAG1, KRT1, PRF1, ADAR
6	cellular phenotype	MP:0005384	5.4	IFNG, TNF, TMPO, DAG1, PSMB10, PRF1

Articles related to lymphocytic choriomeningitis:

(show all 12)

id	Title	Authors	Year	Affiliating Genes
1	The nucleoprotein of lymphocytic choriomeningitis vir us facilitates spread of persistent infection through stabilization of the kera tin network. (19494018)	Labudova M.... Pastorekova S.	2009	KRT1
2	MyD88 plays a critical T cell-intrinsic role in supporting CD8 T cell expansion during acute lymphocytic choriomeningitis virus infection. (18768833)	Rahman A.H.... Turka L.A.	2008	MYD88
3	A-to-G hypermutation in the genome of lymphocytic choriomeningitis virus. (17020943)	Zahn R.C.... von Laer D.	2007	ADAR
4	Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus. (16940530)	Martinez-Sobrido L.... de la Torre J.C.	2006	IRF3
5	Lymphocytic choriomeningitis virus mx strain does not induce the expression of tumor-associated carbonic anhydrase IX in persistently infected HeLa cells. (16599186)	Labudova M.... Pastorekova S.	2006	CA9
6	Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningiti s virus. (16940520)	Kunz S.... de la Torre J.C.	2006	IRF9
7	MyD88 is critical for the development of innate and adaptive immunity during acute lymphocytic choriomeningitis virus infection. (15724245)	Zhou S.... Finberg R.W.	2005	MYD88
8	O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. (16254364)	Imperiali M.... Oxenius A.	2005	DAG1
9	Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus. (15246261)	Kunz S.... Oldstone M.B.	2004	DAG1
10	Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. (9851928)	Cao W.... Oldstone M.B.	1998	DAG1
11	Sequence and characterisation of the Z gene encoding ring finger protein of the lymphocytic choriomeningitis virus MX strain. (10358742)	Gibadulinova A.... Pastorek J.	1998	TRIM31, TMBIM4
12	Effect of pretreatment with immunomodulating agents on the outcome of lymphocytic choriomeningitis virus infection in athymic (nude ) and euthymic mice (1442095)	Anderlik P.... Barna Z.	1992	TMPO

Genes related to lymphocytic choriomeningitis according to GeneCards:

(show all 29)

id	Symbol	Description	Score	GeneCards Section Context
1	DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	11.0	Functions, Publications
2	IL7	interleukin 7	11.0
3	TRIM31	tripartite motif containing 31	11.0	Publications
4	TMBIM4	transmembrane BAX inhibitor motif containing 4	11.0	Publications
5	USP18	ubiquitin specific peptidase 18	11.0
6	PSMB10	proteasome (prosome, macropain) subunit, beta type, 10	11.0
7	IRF9	interferon regulatory factor 9	11.0	Publications
8	KLRG1	killer cell lectin-like receptor subfamily G, member 1	11.0
9	GP2	glycoprotein 2 (zymogen granule membrane)	11.0
10	KRT1	keratin 1	11.0	Publications
11	MYD88	myeloid differentiation primary response gene (88)	11.0	Publications
12	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)	11.0
13	IRF3	interferon regulatory factor 3	11.0	Publications
14	ADAR	adenosine deaminase, RNA-specific	11.0	Publications
15	CA9	carbonic anhydrase IX	11.0	Publications
16	CD8A	CD8a molecule	11.0
17	GLRX3	glutaredoxin 3	11.0
18	GTPBP1	GTP binding protein 1	11.0
19	HIST2H2BE	histone cluster 2, H2be	11.0
20	TMPO	thymopoietin	11.0	Publications
21	MBTPS1	membrane-bound transcription factor peptidase, site 1	11.0
22	PRF1	perforin 1 (pore forming protein)	11.0
23	CD4	CD4 molecule	11.0
24	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0
25	GYPC	glycophorin C (Gerbich blood group)	11.0
26	IL2	interleukin 2	11.0
27	IFNA1	interferon, alpha 1	11.0
28	TNF	tumor necrosis factor	11.0
29	IFNG	interferon, gamma	11.0

Pathways related to lymphocytic choriomeningitis according to GeneDecks:

(show all 36)

id	Pathway	Score	Top Affiliating Genes
1	Immune response Role of TLRs 3 and 4 in cell antiviral response- TICAM1-specific signaling pathways10	10.5	IRF3
2	Primary immunodeficiency20	10.4	CD4
3	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.3	IL2
4	Bacterial infections in CF airways41	10.3	MYD88
5	Antigen processing and presentation20	10.2	CD4, CD8A
6	Graft-versus-host disease20	10.0	IL2, PRF1
7	Immune response_IFN alpha/beta signaling pathway41	9.8	IFNA1, IRF9, USP18
8	Immune response IFN alpha/beta signaling pathway10	9.8	IFNA1, IRF9, USP18
9	SREBP Proteolysis36	9.5	MBTPS1, PSMB10, PSMB8
10	Proteasome20	9.5	IFNG, PSMB10, PSMB8
11	SOCS Pathway36	9.4	PSMB8, PSMB10, IL7, IL2, CD4
12	Immune System38	9.2	USP18, CD40, IRF9, IFNG, KLRG1, ADAR
13	Hematopoietic cell lineage20	9.2	CD8A, CD4, IL7, TNF
14	African trypanosomiasis20	9.2	TNF, IFNG, MYD88
15	Immune response_MIF in innate immunity response41	9.1	TNF, IFNG, MYD88
16	Immune response MIF in innate immunity response10	9.1	TNF, IFNG, MYD88
17	Autoimmune thyroid disease20	8.9	PRF1, IFNA1, IL2, CD40
18	Immune response_MIF-mediated glucocorticoid regulation41	8.9	TNF, IFNG, IL2
19	Immune response MIF-mediated glucocorticoid regulation10	8.9	TNF, IFNG, IL2
20	Jak-STAT signaling pathway20	8.9	IRF9, IL2, IL7, IFNA1, IFNG
21	THC Differentiation Pathway36	8.8	IL2, IFNG, TNF
22	Hepatitis C20	8.8	TNF, IFNA1, IRF9, IRF3
23	Toxoplasmosis20	8.7	TNF, IFNG, CD40, MYD88
24	Chagas disease (American trypanosomiasis)20	8.7	TNF, IFNG, IL2, MYD88
25	Type I diabetes mellitus20	8.6	PRF1, TNF, IFNG, IL2
26	Th1 Differentiation37	8.6	CD4, IL2, IFNG, TNF
27	Toll-like receptor signaling pathway20	8.6	MYD88, CD40, IRF3, IFNA1, TNF
28	Systemic lupus erythematosus20	8.5	CD40, IFNG, TNF, HIST2H2BE
29	Malaria20	8.5	TNF, IFNG, GYPC, CD40, MYD88
30	Measles20	8.4	ADAR, IFNG, IFNA1, IL2, IRF9, IRF3
31	Cytokine Network36	8.4	TNF, IFNG, IFNA1, IL2
32	T cell receptor signaling pathway20	8.4	TNF, IFNG, IL2, CD4, CD8A
33	Allograft rejection20	8.3	PRF1, TNF, IFNG, IL2, CD40
34	Natural killer cell mediated cytotoxicity20	8.2	PRF1, TNF, IFNG, IFNA1
35	Influenza A20	8.1	ADAR, TNF, IFNG, IFNA1, IRF9, IRF3
36	Cytokine-cytokine receptor interaction20	7.8	TNF, IFNG, IFNA1, IL7, IL2, CD40

Compounds related to lymphocytic choriomeningitis according to GeneDecks:

(show top 50)    (show all 53)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.3	CD40, IL7
2	pge232	10.2	CD4, TMPO
3	vegf32	9.9	CD40, CA9
4	alpha-galactosylceramide32	9.7	IL2, IL7, IFNG
5	cycloferon32	9.6	IFNA1, IFNG
6	rapamycin32 42	10.5	IL2, IFNG, CA9
7	mizoribine32	9.4	IFNA1, IL2
8	isotretinoin32 9 9	11.4	IL2, IFNA1, KRT1
9	betaseron32	9.3	IFNG, IFNA1
10	intron a32	9.2	IFNA1, IL2
11	glatiramer acetate32 9 9	11.2	IFNG, IFNA1, IL2
12	interferon gamma32	9.0	TNF, IFNG, IL2
13	taurine chloramine32	9.0	IL2, IFNG, TNF
14	gold sodium thiomalate32	9.0	TNF, IFNG, IL2
15	zidovudine32 9 9	10.9	TMPO, IFNA1, IL2, CD4
16	okt332	8.9	TNF, IFNG, IL7, IL2
17	ifn-alpha32	8.9	IFNG, IFNA1, IL2, IRF9, IRF3
18	mycophenolate mofetil32 9 9	10.8	CD40, IL2, IFNA1, IFNG
19	gm-csf32	8.8	IL2, IFNG, TNF
20	imiquimod32 42 9 9	11.8	IFNA1, IFNG, TNF
21	indoleamine32	8.8	TNF, IFNG, IFNA1
22	lactacystin32	8.7	HIST2H2BE, TNF, IFNG, CD4
23	poly(i-c)32	8.7	TNF, IFNG, IFNA1, IRF3
24	endotoxin32	8.7	TNF, IFNG, IRF3, CD40, MYD88
25	triptolide32	8.6	CD40, IL2, IFNG, TNF
26	glucosamine32 9 18 9	11.6	TNF, IFNG, IL2, CD40
27	cyclophosphamide32 34 9 9	11.5	IFNA1, IL7, IL2, CD40
28	hydrocortisone32 9 9	10.5	TNF, IFNG, IL7, IL2, CD40
29	chloroquine32 34 9 9	11.4	TNF, IFNA1, IL2, CD4
30	rituximab32 34 9 9	11.4	TNF, IFNA1, IL2, CD40
31	thalidomide32 42 9 9	11.3	TNF, IFNG, IFNA1, IL2
32	il-1232	8.3	TNF, IFNG, IFNA1, IL7, IL2
33	il 1032	8.3	TNF, IFNG, IL7, IL2, CD40, CD8A
34	herbimycin a32 42	9.2	TNF, IFNG, IL2, CD40, CD4
35	histamine32 18	9.1	IFNG, IL7, IL2, CD40, TNF
36	2,5-oligoadenylate32	8.1	IL2, IFNA1, IFNG, TNF, ADAR, IRF9
37	indomethacin32 9 9	10.0	TMPO, TNF, IFNG, IL2, CD40
38	prednisolone32 9 9	10.0	TNF, IFNG, IFNA1, IL2, CD40
39	genistein32 9 18 9	10.9	TNF, IFNG, IL7, IL2, IRF9, CD40
40	tacrolimus32 34 9 9	10.9	TNF, IFNG, IFNA1, IL7, IL2, CD40
41	polyinosinic-polycytidylic acid32	7.8	TNF, IFNG, IFNA1, IL2, IRF3, CD40
42	neopterin32	7.6	TNF, IFNG, IFNA1, IL2, CD40, CD4
43	retinoic acid32 42 18	9.6	KRT1, TNF, IFNG, IFNA1, IL7, IRF9
44	cyclosporin a32 42	8.5	TMPO, TNF, IFNG, IFNA1, IL7, IL2
45	lipid32	7.5	KRT1, TNF, GP2, MBTPS1, IL7, IRF3
46	thymidine32 18	8.3	TNF, IFNG, IFNA1, IL7, IL2, GYPC
47	rantes32	7.1	MYD88, TNF, IFNG, IFNA1, IL7, IL2
48	cycloheximide32	6.8	PRF1, TNF, IFNG, IFNA1, IL7, IL2
49	tyrosine32	6.7	IL7, IFNA1, CA9, TMPO, KRT1, PSMB8
50	serine32	6.2	PRF1, KRT1, TMBIM4, TNF, IFNA1, MBTPS1

Cellular components related to lymphocytic choriomeningitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.1	CD8A, CD4, CD40, IFNG, TNF

Biological processes related to lymphocytic choriomeningitis according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	type I interferon biosynthetic process	GO:045351	10.2	MYD88, IRF3, IRF9
2	type I interferon-mediated signaling pathway	GO:060337	9.8	ADAR, PSMB8, IRF9, IRF3, USP18
3	positive regulation of interleukin-23 production	GO:032747	9.8	MYD88, IFNG
4	positive regulation of B cell proliferation	GO:030890	9.5	IL7, IL2, CD40
5	lipopolysaccharide-mediated signaling pathway	GO:031663	9.4	MYD88, IRF3, TNF
6	positive regulation of vitamin D biosynthetic process	GO:060557	9.3	TNF, IFNG
7	positive regulation of isotype switching to IgG isotypes	GO:048304	9.3	IFNG, IL2, CD40
8	cell surface receptor signaling pathway	GO:007166	9.2	MYD88, CD4, IRF9, IFNG, KLRG1
9	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.2	IFNG, TNF
10	defense response to virus	GO:051607	9.2	CD40, IRF3, IFNG, PRF1
11	positive regulation of chemokine biosynthetic process	GO:045080	9.2	TNF, IFNG, MYD88
12	negative regulation of growth of symbiont in host	GO:044130	9.2	TNF, IFNG, MYD88
13	regulation of immunoglobulin secretion	GO:051023	9.1	CD40, TNF
14	cytokine-mediated signaling pathway	GO:019221	9.1	MYD88, USP18, IRF3, IRF9, IFNG, PSMB8
15	humoral immune response	GO:006959	9.1	IL7, IFNG, TNF, PSMB10
16	response to virus	GO:009615	8.8	MYD88, IRF9, IFNG, TNF
17	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	8.5	TNF, IRF3, CD40, MYD88

Molecular functions related to lymphocytic choriomeningitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	8.5	IL2, IL7, IFNG, TNF