LCM
MCID: LYM009
MIFTS: 43

Lymphocytic Choriomeningitis (LCM) malady

Categories: Infectious diseases, Immune diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

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Aliases & Descriptions for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 11 50 2 39 13 68
Lcm 11 2
Lymphocytic Choriomeningitis Virus Encephalomyelitis 11
 
Non-Arthropod Borne Lymphocytic Choriomeningitis 68
Lymphocytic Meningoencephalitis 11
Lymphocytic Meningitis 11

Classifications:



External Ids:

Disease Ontology11 DOID:12155
ICD1030 A87.2
ICD9CM32 049.0
MeSH39 D008216

Summaries for Lymphocytic Choriomeningitis

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Disease Ontology:11 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary: Lymphocytic Choriomeningitis, also known as LCM, is related to mollaret meningitis and osmotic diarrhea, and has symptoms including fever, lack of appetite and headache. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1). Affiliated tissues include brain, meninges and t cells, and related mouse phenotypes are Decreased Salmonella-containing vacuole maturation and Decreased human parainfluenza virus type 3 (HPIV3) infection.

CDC:2 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia:71 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

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Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to lymphocytic choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

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Symptoms:

 11 (show all 7)
  • fever
  • lack of appetite
  • headache
  • muscle aches
  • malaise
  • nausea
  • vomiting

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00133-A-29.9ATP6AP2, COPA, TYRO3
2GR00241-A-49.7COPA, EIF3G, NOP56
3GR00195-A-29.6ATP6AP2, COPA, EIF3G
4GR00366-A-849.6COPA, EIF3G, NRL
5GR00255-A-18.5AXL, COPA, EIF3G, TYRO3
6GR00241-A-37.8ATP6AP2, ATP6V0B, CARD14, COPA, EIF3G, NOP56
7GR00241-A-14.0ATP6AP2, ATP6V0B, CARD14, COPA, EIF3G, NOP56

Drugs & Therapeutics for Lymphocytic Choriomeningitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Lymphocytic Choriomeningitis


Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

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Anatomical Context for Lymphocytic Choriomeningitis

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MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

36
T cells, Brain, Spleen, B cells, Liver, Monocytes, Nk cells

FMA organs/tissues related to Lymphocytic Choriomeningitis:

17
Brain, Meninges

Publications for Lymphocytic Choriomeningitis

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Articles related to Lymphocytic Choriomeningitis:

(show top 50)    (show all 549)
idTitleAuthorsYear
1
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. (27795301)
2017
2
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. (27899229)
2017
3
Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015. (26963688)
2016
4
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection. (27549169)
2016
5
Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus. (27265463)
2016
6
Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection. (27721109)
2016
7
Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection. (26973071)
2016
8
Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection. (26982463)
2016
9
T-Cells Underlie Some but Not All of the Cerebellar Pathology in a Neonatal Rat Model of Congenital Lymphocytic Choriomeningitis Virus Infection. (27667772)
2016
10
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice. (27404802)
2016
11
Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice. (27581982)
2016
12
Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana. (26631809)
2016
13
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. (27076310)
2016
14
The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. (27010636)
2016
15
Lymphocytic choriomeningitis virus differentially affects virus-induced type I IFN response and mitochondrial apoptosis mediated by RIG-I/MAVS. (25833049)
2015
16
Maternal onset de novo SH2D1A mutation and lymphocytic choriomeningitis virus infection in a patient with Xa89linked lymphoproliferative disease type 1: a case report. (25572984)
2015
17
Lymphocytic choriomeningitis virus infection induced by percutaneous exposure. (26416845)
2015
18
The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity. (26355095)
2015
19
Lymphocytic choriomeningitis and alpha-chemokines. (26152632)
2015
20
Peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis. (26319106)
2015
21
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain. (26423945)
2015
22
Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. (26290604)
2015
23
Antiviral Effect of Interferon Lambda Against Lymphocytic Choriomeningitis Virus. (25830339)
2015
24
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation - Iowa, 2013. (24647402)
2014
25
Lymphocytic choriomeningitis virus in employees and mice at multipremises feeder-rodent operation, United States, 2012. (24447605)
2014
26
Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness. (24829355)
2014
27
Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC. (25281716)
2014
28
Evidence of lymphocytic choriomeningitis virus in domestic mice in Gabon; risk of emergence of LCMV encephalitis in Central Africa. (25378495)
2014
29
Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution. (25395301)
2014
30
Trace-forward investigation of mice in response to lymphocytic choriomeningitis virus outbreak. (24447898)
2014
31
Pseudotyping lentiviral vectors with lymphocytic choriomeningitis virus glycoproteins for transduction of dendritic cells and in vivo immunization. (25416034)
2014
32
IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. (24760883)
2014
33
Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes. (24928036)
2014
34
Protracted Symptoms in Lymphocytic Choriomeningitis: A Case Report. (24736119)
2014
35
Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone. (24802239)
2014
36
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro. (24155390)
2014
37
Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses. (25015511)
2014
38
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation-Iowa, 2013. (24854024)
2014
39
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. (23269247)
2013
40
Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? (23325690)
2013
41
Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza. (23341590)
2013
42
Lymphocytic choriomeningitis virus: invisible but not innocent. (23600874)
2013
43
PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. (24049180)
2013
44
Lymphocytic choriomeningitis virus infections among American Indians. (23460992)
2013
45
Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1. (24101548)
2013
46
Congenital Lymphocytic Choriomeningitis Virus: When to Consider the Diagnosis. (23666045)
2013
47
Reactive oxygen species delay control of lymphocytic choriomeningitis virus. (23328631)
2013
48
Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. (23490048)
2013
49
Role of lymphocytic choriomeningitis virus (LCMV) in understanding viral immunology: past, present and future. (23202498)
2012
50
Isolation and characterization of a new strain of lymphocytic choriomeningitis virus from rodents in southwestern France. (22651393)
2012

Variations for Lymphocytic Choriomeningitis

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Expression for genes affiliated with Lymphocytic Choriomeningitis

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Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for genes affiliated with Lymphocytic Choriomeningitis

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GO Terms for genes affiliated with Lymphocytic Choriomeningitis

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Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1apoptotic cell clearanceGO:004327710.3AXL, TYRO3
2forebrain cell migrationGO:002188510.3AXL, TYRO3
3natural killer cell differentiationGO:000177910.3AXL, TYRO3
4negative regulation of lymphocyte activationGO:005125010.3AXL, TYRO3
5ovulation cycleGO:004269810.3AXL, TYRO3
6protein kinase B signalingGO:004349110.3AXL, TYRO3
7secretion by cellGO:003294010.3AXL, TYRO3
8substrate adhesion-dependent cell spreadingGO:003444610.3AXL, TYRO3
9vagina developmentGO:006006810.3AXL, TYRO3
10viral entry into host cellGO:00467189.7AXL, CLEC4G, DAG1, TYRO3
11viral processGO:00160329.1AXL, CLEC4G, DAG1, TYRO3

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol 3-kinase bindingGO:004354810.2AXL, TYRO3
2transmembrane receptor protein tyrosine kinase activityGO:000471410.1AXL, TYRO3
3virus receptor activityGO:00016189.1AXL, CLEC4G, DAG1, TYRO3

Sources for Lymphocytic Choriomeningitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet