LCM
MCID: LYM009
MIFTS: 43

Lymphocytic Choriomeningitis (LCM) malady

Categories: Infectious diseases, Immune diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

Aliases & Descriptions for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 52 3 42 14 69
Lcm 12 3
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 69
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
ICD10 33 A87.2
ICD9CM 35 049.0
MeSH 42 D008216

Summaries for Lymphocytic Choriomeningitis

Disease Ontology : 12 A viral infectious disease that results_in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lcm, is related to mollaret meningitis and osmotic diarrhea, and has symptoms including fever, lack of appetite and headache. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1). Affiliated tissues include t cells, brain and spleen, and related phenotype is Decreased vesicular stomatitis virus (VSV) infection.

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia : 71 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
id Related Disease Score Top Affiliating Genes
1 mollaret meningitis 10.9
2 osmotic diarrhea 10.1 AXL TYRO3
3 meningitis 10.1
4 hepatitis 10.0
5 nervous system disease 10.0
6 central nervous system disease 10.0
7 nasopharyngeal disease 10.0 AXL DAG1
8 growth hormone deficiency 10.0
9 neuronitis 10.0
10 cerebellar hypoplasia 9.9
11 influenza 9.9
12 chorioretinitis 9.9
13 meningoencephalitis 9.9
14 hydrocephalus 9.9
15 stomatitis 9.9
16 mhc class ii deficiency 9.8
17 hemorrhagic fever 9.8
18 cytomegalovirus infection 9.8
19 leukemia 9.8
20 mucositis 9.8
21 lassa fever 9.8
22 orchitis 9.8
23 encephalitis 9.8
24 vaccinia 9.8
25 mumps 9.8
26 toxoplasmosis 9.8
27 parotitis 9.8
28 glioma 9.8
29 obesity 9.6
30 q fever 9.6
31 thyroiditis 9.6
32 aplastic anemia 9.6
33 rickettsialpox 9.6
34 autoimmune hemolytic anemia 9.6
35 hydrops fetalis 9.6
36 keratitis 9.6
37 pertussis 9.6
38 choroiditis 9.6
39 peritonitis 9.6
40 ocular toxoplasmosis 9.6
41 hemolytic anemia 9.6
42 aseptic meningitis 9.6
43 congenital toxoplasmosis 9.6
44 herpes simplex 9.6
45 hypoxia 9.6
46 lymphogranuloma venereum 9.6
47 endotheliitis 9.6
48 histoplasmosis 9.6
49 malignant glioma 9.6
50 b cell deficiency 9.6

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

Symptoms:

12
  • fever
  • lack of appetite
  • headache
  • muscle aches
  • malaise
  • nausea
  • vomiting

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 10.1 NOP56 NRL ATP6AP2 ATP6V0B CARD14 COPA
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 10.1 NOP56 NRL ATP6AP2 ATP6V0B CARD14 COPA
3 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.87 COPA EIF3G NOP56 NRL ATP6AP2 ATP6V0B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.85 EIF3G
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.85 EIF3G
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.85 COPA
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.85 COPA
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.85 EIF3G
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.85 NRL
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.85 EIF3G
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.85 COPA EIF3G NRL
12 Decreased human parainfluenza virus type 3 (HPIV3) infection GR00241-A-4 9.58 COPA EIF3G NOP56
13 Decreased influenza A H1N1 (A/WSN/33) virus numbers GR00195-A-2 9.54 ATP6AP2 COPA EIF3G
14 Decreased Salmonella-containing vacuole maturation GR00133-A-2 9.43 ATP6AP2 COPA TYRO3
15 Negative genetic interaction between BLM-/- and BLM+/+ GR00255-A-1 8.92 AXL COPA EIF3G TYRO3

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Search Clinical Trials , NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

39
T Cells, Brain, Spleen, B Cells, Liver, Monocytes, Nk Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Lymphocytic Choriomeningitis:

18
Brain, Brain, Meninges

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 549)
id Title Authors Year
1
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
2
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. ( 27899229 )
2017
3
Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015. ( 26963688 )
2016
4
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection. ( 27549169 )
2016
5
Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus. ( 27265463 )
2016
6
Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection. ( 27721109 )
2016
7
Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection. ( 26973071 )
2016
8
Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection. ( 26982463 )
2016
9
T-Cells Underlie Some but Not All of the Cerebellar Pathology in a Neonatal Rat Model of Congenital Lymphocytic Choriomeningitis Virus Infection. ( 27667772 )
2016
10
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice. ( 27404802 )
2016
11
Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice. ( 27581982 )
2016
12
Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana. ( 26631809 )
2016
13
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. ( 27076310 )
2016
14
The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. ( 27010636 )
2016
15
Lymphocytic choriomeningitis virus differentially affects virus-induced type I IFN response and mitochondrial apoptosis mediated by RIG-I/MAVS. ( 25833049 )
2015
16
Maternal onset de novo SH2D1A mutation and lymphocytic choriomeningitis virus infection in a patient with Xa89linked lymphoproliferative disease type 1: a case report. ( 25572984 )
2015
17
Lymphocytic choriomeningitis virus infection induced by percutaneous exposure. ( 26416845 )
2015
18
The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity. ( 26355095 )
2015
19
Lymphocytic choriomeningitis and alpha-chemokines. ( 26152632 )
2015
20
Peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis. ( 26319106 )
2015
21
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain. ( 26423945 )
2015
22
Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. ( 26290604 )
2015
23
Antiviral Effect of Interferon Lambda Against Lymphocytic Choriomeningitis Virus. ( 25830339 )
2015
24
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation - Iowa, 2013. ( 24647402 )
2014
25
Lymphocytic choriomeningitis virus in employees and mice at multipremises feeder-rodent operation, United States, 2012. ( 24447605 )
2014
26
Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness. ( 24829355 )
2014
27
Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC. ( 25281716 )
2014
28
Evidence of lymphocytic choriomeningitis virus in domestic mice in Gabon; risk of emergence of LCMV encephalitis in Central Africa. ( 25378495 )
2014
29
Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution. ( 25395301 )
2014
30
Trace-forward investigation of mice in response to lymphocytic choriomeningitis virus outbreak. ( 24447898 )
2014
31
Pseudotyping lentiviral vectors with lymphocytic choriomeningitis virus glycoproteins for transduction of dendritic cells and in vivo immunization. ( 25416034 )
2014
32
IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. ( 24760883 )
2014
33
Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes. ( 24928036 )
2014
34
Protracted Symptoms in Lymphocytic Choriomeningitis: A Case Report. ( 24736119 )
2014
35
Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone. ( 24802239 )
2014
36
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro. ( 24155390 )
2014
37
Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses. ( 25015511 )
2014
38
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation-Iowa, 2013. ( 24854024 )
2014
39
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. ( 23269247 )
2013
40
Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? ( 23325690 )
2013
41
Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza. ( 23341590 )
2013
42
Lymphocytic choriomeningitis virus: invisible but not innocent. ( 23600874 )
2013
43
PC61 (anti-CD25) treatment inhibits influenza A virus-expanded regulatory T cells and severe lung pathology during a subsequent heterologous lymphocytic choriomeningitis virus infection. ( 24049180 )
2013
44
Lymphocytic choriomeningitis virus infections among American Indians. ( 23460992 )
2013
45
Exogenous OX40 stimulation during lymphocytic choriomeningitis virus infection impairs follicular Th cell differentiation and diverts CD4 T cells into the effector lineage by upregulating Blimp-1. ( 24101548 )
2013
46
Congenital Lymphocytic Choriomeningitis Virus: When to Consider the Diagnosis. ( 23666045 )
2013
47
Reactive oxygen species delay control of lymphocytic choriomeningitis virus. ( 23328631 )
2013
48
Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. ( 23490048 )
2013
49
Role of lymphocytic choriomeningitis virus (LCMV) in understanding viral immunology: past, present and future. ( 23202498 )
2012
50
Isolation and characterization of a new strain of lymphocytic choriomeningitis virus from rodents in southwestern France. ( 22651393 )
2012

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

GO Terms for Lymphocytic Choriomeningitis

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.76 AXL CLEC4G DAG1 TYRO3
2 substrate adhesion-dependent cell spreading GO:0034446 9.49 AXL TYRO3
3 protein kinase B signaling GO:0043491 9.48 AXL TYRO3
4 apoptotic cell clearance GO:0043277 9.43 AXL TYRO3
5 natural killer cell differentiation GO:0001779 9.4 AXL TYRO3
6 secretion by cell GO:0032940 9.37 AXL TYRO3
7 ovulation cycle GO:0042698 9.32 AXL TYRO3
8 vagina development GO:0060068 9.26 AXL TYRO3
9 forebrain cell migration GO:0021885 9.16 AXL TYRO3
10 negative regulation of lymphocyte activation GO:0051250 8.96 AXL TYRO3
11 viral entry into host cell GO:0046718 8.92 AXL CLEC4G DAG1 TYRO3

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 AXL TYRO3
2 phosphatidylinositol 3-kinase binding GO:0043548 8.96 AXL TYRO3
3 virus receptor activity GO:0001618 8.92 AXL CLEC4G DAG1 TYRO3

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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48 NDF-RT
51 NINDS
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55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
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68 Tocris
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70 UMLS via Orphanet
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