LCM
MCID: LYM009
MIFTS: 56

Lymphocytic Choriomeningitis (LCM) malady

Infectious diseases, Immune diseases categories

Summaries for Lymphocytic Choriomeningitis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in lymphocytic choriomeningitis virus, which is transmitted by common house mouse, mus musculus. the infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards: Lymphocytic Choriomeningitis, also known as lymphocytic choriomeningitis virus encephalomyelitis, is related to hepatitis and influenza, and has symptoms including lack of appetite, headache and muscle aches. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)), and among its related pathways are Apoptosis Modulation and Signaling and Cytosolic DNA-sensing pathway. The compounds proline and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include brain, meninges and t cells, and related mouse phenotypes are hematopoietic system and cellular.

Wikipedia:63 Lymphocytic choriomeningitis (LCM), is a rodent-borne viral infectious disease that presents as aseptic... more...

Aliases & Classifications for Lymphocytic Choriomeningitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphocytic choriomeningitis 8 10 44 60
lymphocytic choriomeningitis virus encephalomyelitis 8
lymphocytic meningoencephalitis 8
lymphocytic meningitis 8
lcm 8


External Ids:

Disease Ontology8 DOID:12155
MeSH34 D008216
ICD1025 A87.2

Related Diseases for Lymphocytic Choriomeningitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to lymphocytic choriomeningitis

Clinical Features for Lymphocytic Choriomeningitis

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • lack of appetite
  • headache
  • muscle aches
  • malaise
  • nausea
  • vomiting
  • fever

Drugs & Therapeutics for Lymphocytic Choriomeningitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphocytic Choriomeningitis

Drug clinical trials:

Search ClinicalTrials for Lymphocytic Choriomeningitis

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Search CenterWatch for Lymphocytic Choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

About this section

Anatomical Context for Lymphocytic Choriomeningitis

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

32
T cells, Brain, Spleen, B cells, Liver, Bone, Bone marrow, Nk cells, Monocytes, Lung, Kidney, Testes, Thyroid, Endothelial

FMA organs/tissues related to Lymphocytic Choriomeningitis:

14
Brain, Meninges

Animal Models for Lymphocytic Choriomeningitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.2PSMB10, USP18, PRF1, MYD88, IL7, TMPO
2MP:00053848.7ADAR, IRF3, PSMB10, USP18, PRF1, HIST2H2BE
3MP:00053878.7IRF3, IRF9, PSMB8, PSMB10, USP18, PRF1

Publications for Lymphocytic Choriomeningitis

About this section
Sources:
50PubMed
See all sources

Articles related to Lymphocytic Choriomeningitis:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
Lymphocytic choriomeningitis virus: invisible but not innocent. (23600874)
2013
2
Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. (22889536)
2012
3
Differential impact of interferon regulatory factor 7 in initiation of the type I interferon response in the lymphocytic choriomeningitis virus-infected central nervous system versus the periphery. (22514347)
2012
4
Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice. (21507976)
2011
5
Human CD8a8_ and CD4a8_ T cell memory to lymphocytic choriomeningitis virus infection. (21900169)
2011
6
Comparison of cytotoxic T lymphocyte efficacy in acute and persistent lymphocytic choriomeningitis virus infection. (21450739)
2011
7
Lymphocytic choriomeningitis virus meningitis, New York, NY, USA, 2009. (20113573)
2010
8
Detection of the antibody to lymphocytic choriomeningitis virus in sera of laboratory rodents infected with viruses of laboratory and newly isolated strains by ELISA using purified recombinant nucleoprotein. (18633158)
2008
9
Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin. (18606656)
2008
10
Genetic mimics of congenital lymphocytic choriomeningitis virus encephalitis. (18409198)
2008
11
Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses. (18829752)
2008
12
Signal peptide requirements for lymphocytic choriomeningitis virus glycoprotein C maturation and virus infectivity. (17804515)
2007
13
Survey of lymphocytic choriomeningitis virus diagnosis and testing--Connecticut, 2005. (16617288)
2006
14
Aicardi-like chorioretinitis and maldevelopment of the corpus callosum in congenital lymphocytic choriomeningitis virus. (16527682)
2006
15
Interim guidance for minimizing risk for human lymphocytic choriomeningitis virus infection associated with rodents. (16079740)
2005
16
Rapid activation of spleen dendritic cell subsets following lymphocytic choriomeningitis virus infection of mice: analysis of the involvement of type 1 IFN. (15699111)
2005
17
Detection of lymphocytic choriomeningitis virus by use of fluorogenic nuclease reverse transcriptase-polymerase chain reaction analysis. (12625508)
2003
18
T cell responses to viral infections: lessons from lymphocytic choriomeningitis virus. (12403369)
2002
19
Lymphocytic choriomeningitis virus: emerging fetal teratogen. (12501090)
2002
20
Lymphocytic choriomeningitis virus: an underdiagnosed cause of congenital chorioretinitis. (11004296)
2000
21
Overexpression of the proteasome subunits LMP2, LMP7, and MECL-1, but not PA28 alpha/beta, enhances the presentation of an immunodominant lymphocytic choriomeningitis virus T cell epitope. (10878350)
2000
22
Noncytopathic clearance of lymphocytic choriomeningitis virus from the hepatocyte. (10330434)
1999
23
Lymphocytic responses and the gradual hippocampal neuron loss following infection with lymphocytic choriomeningitis virus (LCMV). (10580797)
1999
24
Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. (9499083)
1998
25
Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. (9851928)
1998
26
Long-term CD4 Th1 and Th2 memory following acute lymphocytic choriomeningitis virus infection. (9733872)
1998
27
Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection. (9164957)
1997
28
Virus-specific, CD8+ major histocompatibility complex class I-restricted cytotoxic T lymphocytes in lymphocytic choriomeningitis virus-infected beta2-microglobulin-deficient mice. (9343195)
1997
29
Age distribution of lymphocytic choriomeningitis virus serum antibody in Birmingham, Alabama: evidence of a decreased risk of infection. (9242315)
1997
30
The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic T cell epitope that is restricted by both H-2D(b) and H-2K(b) molecules. (9234947)
1997
31
Exacerbation of lymphocytic choriomeningitis in mice treated with the inducible nitric oxide synthase inhibitor aminoguanidine. (8982100)
1996
32
Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes. (7533855)
1995
33
Mechanism of lymphocytic choriomeningitis virus entry into cells. (8259643)
1994
34
Altered cytokine genes expression by conA-activated spleen cells from mice infected by lymphocytic choriomeningitis virus. (7685735)
1993
35
Biochemical and immunological evidence that the 11 kDa zinc-binding protein of lymphocytic choriomeningitis virus is a structural component of the virus. (1626415)
1992
36
Restricted V-segment usage in T-cell receptors from cytotoxic T lymphocytes specific for a major epitope of lymphocytic choriomeningitis virus. (1700830)
1990
37
Detection of virus-specific RNA-dependent RNA polymerase activity in extracts from cells infected with lymphocytic choriomeningitis virus: in vitro synthesis of full-length viral RNA species. (2704071)
1989
38
Major histocompatibility complex--dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease. (2477254)
1989
39
Polymorphism of cytotoxic T-lymphocyte clones that recognize a defined nine-amino-acid immunodominant domain of lymphocytic choriomeningitis virus glycoprotein. (2467990)
1989
40
Clearance of lymphocytic choriomeningitis virus in antibody- and B-cell-deprived mice. (3258641)
1988
41
Immunogenetic analysis of cellular interactions governing the recruitment of T lymphocytes and monocytes in lymphocytic choriomeningitis virus-induced immunopathology. (3258209)
1988
42
Immunosuppression-induced susceptibility of inbred hamsters (Mesocricetus auratus) to lethal-disease by lymphocytic choriomeningitis virus infection. (3689153)
1987
43
The acute inflammatory process in murine lymphocytic choriomeningitis is dependent on Lyt-2+ immune T cells. (3495350)
1987
44
Phenotypic analysis of the inflammatory exudate in murine lymphocytic choriomeningitis. (3108445)
1987
45
Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response. (3494855)
1987
46
Oligoclonal immunoglobulin bands in cerebrospinal fluid of a patient with lymphocytic choriomeningitis. (3707091)
1986
47
Contamination of transplantable murine tumors with lymphocytic choriomeningitis virus. (3702331)
1986
48
Immunohistochemical analysis of the involvement of F4/80 and Ia-positive macrophages in mouse liver infected with lymphocytic choriomeningitis virus. (3464677)
1986
49
The use of lymphocytic choriomeningitis virus reassortants to map viral genes causing virulence. (3724665)
1986
50
Consequences of cyclophosphamide treatment in murine lymphocytic choriomeningitis: evidence for cytotoxic T cell replication in vivo. (3877978)
1985

Genetic Variations for Lymphocytic Choriomeningitis

About this section

Expression for genes affiliated with Lymphocytic Choriomeningitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for genes affiliated with Lymphocytic Choriomeningitis

About this section
Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 12EMD Millipore
See all sources

Compounds for genes affiliated with Lymphocytic Choriomeningitis

About this section
Sources:
44Novoseek
See all sources

Compounds related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1proline449.9KRT1, IL7, MYD88, CA9
2tyrosine448.8TMPO, CA9, IRF3, IRF9, PSMB8, MYD88

GO Terms for genes affiliated with Lymphocytic Choriomeningitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteasome core complexGO:00583910.1PSMB10, PSMB8
2spermatoproteasome complexGO:199011110.0PSMB10, PSMB8
3nucleoplasmGO:0056549.1IRF3, IRF9, PSMB8, PSMB10, DAG1, ADAR

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1type I interferon biosynthetic processGO:04535110.0IRF9, IRF3
2defense response to virusGO:0516079.8IRF3, IRF9, PRF1, ADAR
3modulation by virus of host morphology or physiologyGO:0190489.8DAG1, PSMB10, PSMB8, IRF3
4type I interferon-mediated signaling pathwayGO:0603379.7ADAR, USP18, PSMB8, IRF9, IRF3
5cytokine-mediated signaling pathwayGO:0192219.7IRF3, IRF9, PSMB8, USP18, ADAR
6negative regulation of apoptotic processGO:0430669.6PSMB8, PSMB10, MYD88, IL7, TMBIM4, ADAR
7apoptotic processGO:0069159.3IRF3, PSMB8, PSMB10, PRF1, TMBIM4

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1threonine-type endopeptidase activityGO:00429810.1PSMB10, PSMB8
2protein bindingGO:0055158.3ADAR, IRF3, IRF9, PSMB8, USP18, PRF1

Products for genes affiliated with Lymphocytic Choriomeningitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphocytic Choriomeningitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet