MCID: LYM009
MIFTS: 49

Lymphocytic Choriomeningitis malady

Categories: Infectious diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

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Aliases & Descriptions for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 11 13 48 2 37 66
Lcm 11 2
Lymphocytic Choriomeningitis Virus Encephalomyelitis 11
 
Non-Arthropod Borne Lymphocytic Choriomeningitis 66
Lymphocytic Meningoencephalitis 11
Lymphocytic Meningitis 11

Classifications:



External Ids:

Disease Ontology11 DOID:12155
ICD1028 A87.2
ICD9CM30 049.0
MeSH37 D008216

Summaries for Lymphocytic Choriomeningitis

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Disease Ontology:11 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in lymphocytic choriomeningitis virus, which is transmitted by common house mouse, mus musculus. the infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary: Lymphocytic Choriomeningitis, also known as lcm, is related to aseptic meningitis and mollaret meningitis, and has symptoms including fever, lack of appetite and headache. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways are Immune response IFN alpha/beta signaling pathway and Interferon gamma signaling. Affiliated tissues include brain, meninges and t cells, and related mouse phenotypes are cellular and hematopoietic system.

Wikipedia:69 Lymphocytic choriomeningitis (LCM), is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

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Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to lymphocytic choriomeningitis

Symptoms for Lymphocytic Choriomeningitis

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Symptoms:

 11 (show all 7)
  • fever
  • lack of appetite
  • headache
  • muscle aches
  • malaise
  • nausea
  • vomiting

Drugs & Therapeutics for Lymphocytic Choriomeningitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Lymphocytic Choriomeningitis


Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

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Anatomical Context for Lymphocytic Choriomeningitis

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MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

34
T cells, Brain, Spleen, B cells, Liver, Monocytes, Nk cells

FMA organs/tissues related to Lymphocytic Choriomeningitis:

17
Brain, Meninges

Animal Models for Lymphocytic Choriomeningitis or affiliated genes

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MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053847.2ADAR, AXL, CD86, DAG1, DDX58, IRF3
2MP:00053976.7ADAR, AXL, CD86, CLEC4G, DDX58, KRT1
3MP:00053876.2ADAR, AXL, CD86, CLEC4G, DDX58, IRF3
4MP:00053766.1ADAR, AXL, CD86, CLEC4G, DAG1, DDX58

Publications for Lymphocytic Choriomeningitis

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Articles related to Lymphocytic Choriomeningitis:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. (27076310)
2016
2
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro. (24155390)
2014
3
Trace-forward investigation of mice in response to lymphocytic choriomeningitis virus outbreak. (24447898)
2014
4
Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC. (25281716)
2014
5
Lymphocytic choriomeningitis virus: invisible but not innocent. (23600874)
2013
6
Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice. (22674984)
2012
7
Lymphocytic choriomeningitis virus: an underrecognized cause of neurologic disease in the fetus, child, and adult. (22889536)
2012
8
Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease. (23300439)
2012
9
Lymphocytic choriomeningitis virus (LCMV) infection of macaques: a model for Lassa fever. (21820469)
2011
10
Opposing effects of CD70 costimulation during acute and chronic lymphocytic choriomeningitis virus infection of mice. (21507976)
2011
11
Lymphocytic choriomeningitis virus meningitis, New York, NY, USA, 2009. (20113573)
2010
12
The alternative NF-kappaB signalling pathway is a prerequisite for an appropriate immune response against lymphocytic choriomeningitis virus infection. (20565293)
2010
13
Lymphocytic choriomeningitis virus: a prenatal and postnatal threat. (19968943)
2009
14
Lymphocytic choriomeningitis in a pet store worker in Romania. (18784339)
2008
15
Detection of the antibody to lymphocytic choriomeningitis virus in sera of laboratory rodents infected with viruses of laboratory and newly isolated strains by ELISA using purified recombinant nucleoprotein. (18633158)
2008
16
A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses. (17686978)
2007
17
Congenital viral infections of the brain: lessons learned from lymphocytic choriomeningitis virus in the neonatal rat. (18052527)
2007
18
Protracted course of lymphocytic choriomeningitis virus WE infection in early life: induction but limited expansion of CD8+ effector T cells and absence of memory CD8+ T cells. (17494081)
2007
19
Dissection of antiviral and immune regulatory functions of tumor necrosis factor receptors in a chronic lymphocytic choriomeningitis virus infection. (15047807)
2004
20
Endoproteolytic processing of the lymphocytic choriomeningitis virus glycoprotein by the subtilase SKI-1/S1P. (12584310)
2003
21
Role of the virus nucleoprotein in the regulation of lymphocytic choriomeningitis virus transcription and RNA replication. (12610166)
2003
22
CD94/NKG2 expression does not inhibit cytotoxic function of lymphocytic choriomeningitis virus-specific CD8+ T cells. (12097371)
2002
23
Inducible nitric-oxide synthase plays a minimal role in lymphocytic choriomeningitis virus-induced, T cell-mediated protective immunity and immunopathology. (10580062)
1999
24
Enhanced virus clearance by early inducible lymphocytic choriomeningitis virus-neutralizing antibodies in immunoglobulin-transgenic mice. (9499083)
1998
25
Lymphocytic choriomeningitis virus: a new addition to the TORCH evaluation. (9152144)
1997
26
Protection of mice by an attenuated variant against the wild-type lymphocytic choriomeningitis virus. (9268768)
1997
27
Lymphocytic choriomeningitis virus: a neglected central nervous system pathogen. (8825010)
1996
28
The cell-mediated immune response against lymphocytic choriomeningitis virus in beta 2-microglobulin deficient mice. (8825286)
1995
29
Protection against lethal lymphocytic choriomeningitis virus (LCMV) infection by immunization of mice with an influenza virus containing an LCMV epitope recognized by cytotoxic T lymphocytes. (7514676)
1994
30
Limiting the available T cell receptor repertoire modifies acute lymphocytic choriomeningitis virus-induced immunopathology. (8182114)
1994
31
Aseptic meningitis caused by the lymphocytic choriomeningitis virus. (7924087)
1994
32
Replication of lymphocytic choriomeningitis virus is restricted in terminally differentiated neurons. (8230458)
1993
33
Lymphocytic choriomeningitis virus induces a chronic wasting disease in mice lacking class I major histocompatibility complex glycoproteins. (8103060)
1993
34
The presence of an anti-erythrocyte autoantibody in C3HeB/FeJ mice after lymphocytic choriomeningitis virus infection. (1954312)
1991
35
A single amino acid substitution in an MHC class I molecule allows heteroclitic recognition by lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes. (1907995)
1991
36
A role for transforming growth factor-beta 1 in regulating natural killer cell and T lymphocyte proliferative responses during acute infection with lymphocytic choriomeningitis virus. (1918986)
1991
37
Immunosuppression in mice by lymphocytic choriomeningitis virus infection: time dependence during primary and absence of effects on secondary antibody responses. (2170031)
1990
38
Infection of guinea pigs with two strains of lymphocytic choriomeningitis virus. (2130208)
1990
39
IFN-gamma production in tissues of mice during acute infection with lymphocytic choriomeningitis virus. (2109012)
1990
40
Perturbation of differentiated functions during viral infection in vivo. In vivo relationship of host genes and lymphocytic choriomeningitis virus to growth hormone deficiency. (2221020)
1990
41
Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo. (2514255)
1989
42
Weight loss in obese mice persistently infected with lymphocytic choriomeningitis virus is not associated with elevated tumor necrosis factor/cachectin activity in peritoneal macrophages. (3414785)
1988
43
Virus-lymphocyte interactions. II. Expression of viral sequences during the course of persistent lymphocytic choriomeningitis virus infection and their localization to the L3T4 lymphocyte subset. (2963865)
1988
44
Lymphocytic choriomeningitis virus. X. Demonstration of nucleoprotein on the surface of infected cells. (3336945)
1988
45
State of viral genome and proteins during persistent lymphocytic choriomeningitis virus infection. (2435462)
1987
46
Susceptibility of inbred Syrian golden hamsters (Mesocricetus auratus) to lethal disease by lymphocytic choriomeningitis virus. (3601946)
1987
47
Hybrid resistance modulates the inflammatory process induced by lymphocytic choriomeningitis virus-immune T cells. (3485567)
1986
48
Immunosuppression in experimental trypanosomiasis: effects of Trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. (232108)
1979
49
Pathogenesis of cerebellar hypoplasia produced by lymphocytic choriomeningitis virus infection of neonatal rats. 1. Evolution of disease following infection at 4 days of age. (4568304)
1973
50
Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. (4561841)
1972

Variations for Lymphocytic Choriomeningitis

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Expression for genes affiliated with Lymphocytic Choriomeningitis

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Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for genes affiliated with Lymphocytic Choriomeningitis

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Pathways related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.8ADAR, IRF3, IRF9
2
Show member pathways
8.4ADAR, DDX58, IRF3, IRF9
38.4DDX58, IRF3, MAVS, MYD88
4
Show member pathways
8.4DDX58, IRF3, MAVS, MYD88
58.3DDX58, IRF3, IRF9, MAVS
6
Show member pathways
8.0CD86, DDX58, IRF3, MAVS, MYD88
7
Show member pathways
7.8ADAR, DDX58, IRF3, MAVS, MYD88
8
Show member pathways
7.8ADAR, DDX58, IRF3, IRF9, MAVS
9
Show member pathways
7.5ADAR, DDX58, IRF3, IRF9, MAVS, MYD88
10
Show member pathways
7.1ADAR, CD86, DDX58, IRF3, IRF9, MAVS

GO Terms for genes affiliated with Lymphocytic Choriomeningitis

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Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1toll-like receptor signaling pathwayGO:000222410.3CD86, MYD88
2positive regulation of interleukin-6 productionGO:003275510.1DDX58, MYD88
3positive regulation of tumor necrosis factor productionGO:003276010.1MAVS, MYD88
4type I interferon biosynthetic processGO:004535110.0IRF3, MYD88
5negative regulation of viral genome replicationGO:00450719.9ADAR, MAVS
6lipopolysaccharide-mediated signaling pathwayGO:00316639.9IRF3, MYD88
7positive regulation of interleukin-8 productionGO:00327579.8DDX58, MAVS
8RIG-I signaling pathwayGO:00395299.8DDX58, MAVS
9positive regulation of transcription factor import into nucleusGO:00429939.7DDX58, MAVS
10positive regulation of type I interferon-mediated signaling pathwayGO:00603409.7IRF3, MAVS
11cellular response to lipopolysaccharideGO:00712229.5AXL, CD86, IRF3
12response to virusGO:00096159.4ADAR, DDX58, MYD88
13type I interferon signaling pathwayGO:00603379.4ADAR, IRF3, IRF9
14response to exogenous dsRNAGO:00433309.3DDX58, IRF3
15positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.2IRF3, MAVS, MYD88
16viral entry into host cellGO:00467189.2AXL, CD86, CLEC4G, DAG1
17positive regulation of interferon-alpha productionGO:00327279.0DDX58, IRF3, MAVS
18negative regulation of type I interferon productionGO:00324809.0DDX58, IRF3, MAVS
19positive regulation of interferon-beta productionGO:00327289.0DDX58, IRF3, MAVS
20response to lipopolysaccharideGO:00324968.8CD86, IRF3, MYD88
21positive regulation of type I interferon productionGO:00324818.8IRF3, MAVS, MYD88
22innate immune responseGO:00450878.6ADAR, AXL, DDX58, MAVS, MYD88
23defense response to virusGO:00516077.4ADAR, CD86, IRF3, IRF9, MAVS

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1virus receptor activityGO:00016189.6AXL, CD86, CLEC4G, DAG1
2protein bindingGO:00055155.2ADAR, AXL, CD86, CLEC4G, DAG1, DDX58

Sources for Lymphocytic Choriomeningitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet