LCM
MCID: LYM009
MIFTS: 56

Lymphocytic Choriomeningitis (LCM) malady

Infectious diseases, Immune diseases categories

Summaries for Lymphocytic Choriomeningitis

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in lymphocytic choriomeningitis virus, which is transmitted by common house mouse, mus musculus. the infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards: Lymphocytic Choriomeningitis, also known as lymphocytic choriomeningitis virus encephalomyelitis, is related to hepatitis and influenza, and has symptoms including headache, nausea and vomiting. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)), and among its related pathways are Apoptosis Modulation and Signaling and Cytosolic DNA-sensing pathway. The compounds proline and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include meninges, brain and t cells, and related mouse phenotypes are hematopoietic system and cellular.

Wikipedia:63 Lymphocytic choriomeningitis (LCM), is a rodent-borne viral infectious disease that presents as aseptic... more...

Aliases & Classifications for Lymphocytic Choriomeningitis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphocytic choriomeningitis 8 10 44 60
lymphocytic choriomeningitis virus encephalomyelitis 8
lymphocytic meningoencephalitis 8
lymphocytic meningitis 8
lcm 8


External Ids:

Disease Ontology8 DOID:12155
MeSH34 D008216
ICD1025 A87.2

Related Diseases for Lymphocytic Choriomeningitis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to lymphocytic choriomeningitis

Clinical Features for Lymphocytic Choriomeningitis

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8 (show all 7)
  • headache
  • nausea
  • vomiting
  • malaise
  • lack of appetite
  • muscle aches
  • fever

Drugs & Therapeutics for Lymphocytic Choriomeningitis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphocytic Choriomeningitis

Drug clinical trials:

Search ClinicalTrials for Lymphocytic Choriomeningitis

Search NIH Clinical Center for Lymphocytic Choriomeningitis

Search CenterWatch for Lymphocytic Choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

About this section

Anatomical Context for Lymphocytic Choriomeningitis

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

32
T cells, Brain, Spleen, B cells, Liver, Monocytes, Bone marrow, Nk cells, Bone, Testes, Endothelial, Kidney, Lung, Thyroid

FMA organs/tissues related to Lymphocytic Choriomeningitis:

14
Meninges, Brain

Animal Models for Lymphocytic Choriomeningitis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Lymphocytic Choriomeningitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053979.2PSMB10, USP18, PRF1, MYD88, IL7, TMPO
2MP:00053848.7ADAR, IRF3, PSMB10, USP18, PRF1, HIST2H2BE
3MP:00053878.7IRF3, IRF9, PSMB8, PSMB10, USP18, PRF1

Publications for Lymphocytic Choriomeningitis

About this section
Sources:
50PubMed
See all sources

Articles related to Lymphocytic Choriomeningitis:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. (23490048)
2013
2
Analytical validation of a lymphocytic choriomeningitis virus real-time RT-PCR assay. (21763351)
2011
3
Viral replicative capacity is the primary determinant of lymphocytic choriomeningitis virus persistence and immunosuppression. (21098292)
2010
4
High diversity and ancient common ancestry of lymphocytic choriomeningitis virus. (20587180)
2010
5
Multiple mechanisms contribute to impairment of type 1 interferon production during chronic lymphocytic choriomeningitis virus infection of mice. (19454715)
2009
6
Spatial and temporal dynamics of lymphocytic choriomeningitis virus in wild rodents, northern Italy. (19624914)
2009
7
Lymphocytic choriomeningitis virus (LCMV): propagation, quantitation, and storage. (18770534)
2008
8
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. (18184798)
2008
9
A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8(+) T cell responses. (17686978)
2007
10
CXCL10 is the key ligand for CXCR3 on CD8+ effector T cells involved in immune surveillance of the lymphocytic choriomeningitis virus-infected central nervous system. (16547260)
2006
11
The lymphocytic choriomeningitis virus envelope glycoprotein targets lentiviral gene transfer vector to neural progenitors in the murine brain. (15727934)
2005
12
Lymphocytic choriomeningitis virus infection in a province of Spain: analysis of sera from the general population and wild rodents. (12696116)
2003
13
Arenavirus-mediated liver pathology: acute lymphocytic choriomeningitis virus infection of rhesus macaques is characterized by high-level interleukin-6 expression and hepatocyte proliferation. (12525606)
2003
14
Protection of CD3 delta knockout mice from lymphocytic choriomeningitis virus-induced immunopathology: implications for viral neuroinvasion. (10753703)
2000
15
High frequency of virus-specific interleukin-2-producing CD4(+) T cells and Th1 dominance during lymphocytic choriomeningitis virus infection. (10756059)
2000
16
Lymphocytic choriomeningitis virus chorioretinitis mimicking ocular toxoplasmosis in two otherwise normal children. (11004308)
2000
17
Low prevalence of antibodies against the zoonotic agents Brucella abortus, Leptospira spp., Streptococcus suis serotype II, hantavirus, and lymphocytic choriomeningitis virus among veterinarians and pig farmers in the southern part of The Netherlands. (10321013)
1999
18
Protection against lymphocytic choriomeningitis virus infection induced by a reduced peptide bond analogue of the H-2Db-restricted CD8(+) T cell epitope GP33. (10026170)
1999
19
Sequence comparison of the large genomic RNA segments of two strains of lymphocytic choriomeningitis virus differing in pathogenic potential for guinea pigs. (9857988)
1998
20
Detection of a high frequency of virus-specific CD4+ T cells during acute infection with lymphocytic choriomeningitis virus. (9759834)
1998
21
Sequence and characterisation of the Z gene encoding ring finger protein of the lymphocytic choriomeningitis virus MX strain. (10358742)
1998
22
A novel type of defective viral genome suggests a unique strategy to establish and maintain persistent lymphocytic choriomeningitis virus infections. (9261400)
1997
23
DNA immunization confers protection against lethal lymphocytic choriomeningitis virus infection. (7884923)
1995
24
Enzyme-linked immunosorbent assay for detection of antibody to lymphocytic choriomeningitis virus in mouse sera, with recombinant nucleoprotein as antigen. (8569145)
1995
25
Immune conflicts in lymphocytic choriomeningitis virus. (8571171)
1995
26
Pathology and immunohistochemistry of callitrichid hepatitis, an emerging disease of captive New World primates caused by lymphocytic choriomeningitis virus. (7485406)
1995
27
Lymphocytic choriomeningitis virus: an unrecognized teratogenic pathogen. (8903188)
1995
28
Replication of lymphocytic choriomeningitis virus is restricted in terminally differentiated neurons. (8230458)
1993
29
Congenital lymphocytic choriomeningitis virus infection in twins. (8265286)
1993
30
Cytotoxic T lymphocytes cleanse viral gene products from individually infected neurons and lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus. (8212586)
1993
31
Regulation and function of host defences in the murine lymphocytic choriomeningitis virus infection. (8472597)
1993
32
Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. (1683893)
1991
33
Post-translational processing of the glycoproteins of lymphocytic choriomeningitis virus. (2141203)
1990
34
Enhanced tumor susceptibility of immunocompetent mice infected with lymphocytic choriomeningitis virus. (2289203)
1990
35
Effects of cyclosporin A on IL-2 production and lymphocyte proliferation during infection of mice with lymphocytic choriomeningitis virus. (1967265)
1990
36
Delayed type-hypersensitivity response of inbred strains of Syrian golden hamsters (Mesocricetus auratus) to lethal or non-lethal lymphocytic choriomeningitis virus (LCMV) infections. (2622328)
1989
37
An acquired immune suppression in mice caused by infection with lymphocytic choriomeningitis virus. (2452742)
1988
38
Lymphocytic choriomeningitis virus. X. Demonstration of nucleoprotein on the surface of infected cells. (3336945)
1988
39
Contributions of host and donor T cells to the inflammatory process in murine lymphocytic choriomeningitis. (2972391)
1988
40
Deleted viral RNAs and lymphocytic choriomeningitis virus persistence in vitro. (3404118)
1988
41
State of viral genome and proteins during persistent lymphocytic choriomeningitis virus infection. (2435462)
1987
42
Analysis of the genomic L RNA segment from lymphocytic choriomeningitis virus. (3318094)
1987
43
Natural killer cells contribute to inflammation but do not appear to be essential for the induction of clinical lymphocytic choriomeningitis. (3489282)
1986
44
Studies on the mechanism of lymphocytic choriomeningitis virus homologous interference. (3014286)
1986
45
Numbers of cytolytic T lymphocytes (CTL) and CTL precursor cells in spleens of mice acutely infected with lymphocytic choriomeningitis virus. (3487706)
1986
46
T-cell effector function and unresponsiveness in the murine lymphocytic choriomeningitis virus infection. II. Delayed-type hypersensitivity unresponsiveness reflects a defective differentiation from TD precursor to effector cell. (3489281)
1986
47
Immunosuppression in experimental trypanosomiasis: effects of Trypanosoma brucei on immunization against louping-ill virus and lymphocytic choriomeningitis virus. (232108)
1979
48
Pathogenesis of cerebellar hypoplasia produced by lymphocytic choriomeningitis virus infection of neonatal rats. II. An ultrastructural study of the immune-mediated pathology. (1104999)
1975
49
Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. II. Adoptive immunization of virus carriers. (4622913)
1972
50
Parotitis, orchitis, and meningoencephalitis due to lymphocytic choriomeningitis virus. (13869918)
1962

Genetic Variations for Lymphocytic Choriomeningitis

About this section

Expression for genes affiliated with Lymphocytic Choriomeningitis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for genes affiliated with Lymphocytic Choriomeningitis

About this section
Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 12EMD Millipore
See all sources

Compounds for genes affiliated with Lymphocytic Choriomeningitis

About this section
Sources:
44Novoseek
See all sources

Compounds related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1proline449.9KRT1, IL7, MYD88, CA9
2tyrosine448.8TMPO, CA9, IRF3, IRF9, PSMB8, MYD88

GO Terms for genes affiliated with Lymphocytic Choriomeningitis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1proteasome core complexGO:00583910.1PSMB10, PSMB8
2spermatoproteasome complexGO:199011110.0PSMB10, PSMB8
3nucleoplasmGO:0056549.1IRF3, IRF9, PSMB8, PSMB10, DAG1, ADAR

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1type I interferon biosynthetic processGO:04535110.0IRF9, IRF3
2defense response to virusGO:0516079.8IRF3, IRF9, PRF1, ADAR
3modulation by virus of host morphology or physiologyGO:0190489.8DAG1, PSMB10, PSMB8, IRF3
4type I interferon-mediated signaling pathwayGO:0603379.7ADAR, USP18, PSMB8, IRF9, IRF3
5cytokine-mediated signaling pathwayGO:0192219.7IRF3, IRF9, PSMB8, USP18, ADAR
6negative regulation of apoptotic processGO:0430669.6PSMB8, PSMB10, MYD88, IL7, TMBIM4, ADAR
7apoptotic processGO:0069159.3IRF3, PSMB8, PSMB10, PRF1, TMBIM4

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1threonine-type endopeptidase activityGO:00429810.1PSMB8, PSMB10
2protein bindingGO:0055158.3IRF3, IRF9, PSMB8, USP18, PRF1, MYD88

Products for genes affiliated with Lymphocytic Choriomeningitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphocytic Choriomeningitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet