MCID: LYM009
MIFTS: 39

Lymphocytic Choriomeningitis

Categories: Infectious diseases, Immune diseases

Aliases & Classifications for Lymphocytic Choriomeningitis

MalaCards integrated aliases for Lymphocytic Choriomeningitis:

Name: Lymphocytic Choriomeningitis 12 52 3 42 14 69
Lcm 12 3
Lymphocytic Choriomeningitis Virus Encephalomyelitis 12
Non-Arthropod Borne Lymphocytic Choriomeningitis 69
Lymphocytic Meningoencephalitis 12
Lymphocytic Meningitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12155
ICD10 33 A87.2
ICD9CM 35 049.0
MeSH 42 D008216

Summaries for Lymphocytic Choriomeningitis

Disease Ontology : 12 A viral infectious disease that results_in infection located in brain, or located in meninges, or located in brain and meninges, has material basis in Lymphocytic choriomeningitis virus, which is transmitted_by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting.

MalaCards based summary : Lymphocytic Choriomeningitis, also known as lcm, is related to mollaret meningitis and refractory plasma cell neoplasm. An important gene associated with Lymphocytic Choriomeningitis is DAG1 (Dystroglycan 1), and among its related pathways/superpathways are Tuberculosis and African trypanosomiasis. Affiliated tissues include t cells, brain and spleen, and related phenotype is Decreased vesicular stomatitis virus (VSV) infection.

CDC : 3 Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae, that was initially isolated in 1933.

Wikipedia : 72 Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic... more...

Related Diseases for Lymphocytic Choriomeningitis

Diseases related to Lymphocytic Choriomeningitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 mollaret meningitis 10.9
2 refractory plasma cell neoplasm 10.4 AXL DAG1
3 meningitis 10.1
4 intracranial primitive neuroectodermal tumor 10.0 AXL IL6
5 hepatitis 10.0
6 nervous system disease 10.0
7 central nervous system disease 10.0
8 growth hormone deficiency 10.0
9 neuronitis 10.0
10 rem sleep behavior disorder 10.0 IL6 MYD88
11 influenza 9.9
12 chorioretinitis 9.9
13 cerebellar hypoplasia 9.9
14 secretory diarrhea 9.9 AXL TYRO3
15 queensland tick typhus 9.9 IL6 MYD88
16 hydrocephalus 9.9
17 stomatitis 9.9
18 meningoencephalitis 9.9
19 cytomegalovirus infection 9.8
20 leukemia 9.8
21 mucositis 9.8
22 lassa fever 9.8
23 orchitis 9.8
24 encephalitis 9.8
25 mumps 9.8
26 vaccinia 9.8
27 parotitis 9.8
28 toxoplasmosis 9.8
29 glioma 9.8
30 mhc class ii deficiency 9.8
31 hemorrhagic fever 9.8
32 hemolytic anemia 9.6
33 choroiditis 9.6
34 peritonitis 9.6
35 ocular toxoplasmosis 9.6
36 aseptic meningitis 9.6
37 congenital toxoplasmosis 9.6
38 herpes simplex 9.6
39 hypoxia 9.6
40 lymphogranuloma venereum 9.6
41 endotheliitis 9.6
42 malignant glioma 9.6
43 histoplasmosis 9.6
44 b cell deficiency 9.6
45 trypanosomiasis 9.6
46 hemorrhagic disease 9.6
47 louping ill 9.6
48 viral meningitis 9.6
49 cerebritis 9.6
50 congenital cytomegalovirus 9.6

Graphical network of the top 20 diseases related to Lymphocytic Choriomeningitis:



Diseases related to Lymphocytic Choriomeningitis

Symptoms & Phenotypes for Lymphocytic Choriomeningitis

GenomeRNAi Phenotypes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-1 10.03 ATP6AP2 ATP6V0B CARD14 COPA HNRNPK IFI35
2 Decreased vesicular stomatitis virus (VSV) infection GR00241-A-2 10.03 IFI35 ATP6AP2 ATP6V0B CARD14 COPA HNRNPK
3 Decreased lymphocytic choriomeningitis virus (LCMV) infection GR00241-A-3 9.73 ATP6AP2 ATP6V0B CARD14 COPA HNRNPK IFI35
4 Decreased Salmonella-containing vacuole maturation GR00133-A-2 9.33 ATP6AP2 COPA TYRO3
5 Increased number of mitotic cells GR00098-A-3 8.8 COPA HNRNPK TYRO3

Drugs & Therapeutics for Lymphocytic Choriomeningitis

Search Clinical Trials , NIH Clinical Center for Lymphocytic Choriomeningitis

Cochrane evidence based reviews: lymphocytic choriomeningitis

Genetic Tests for Lymphocytic Choriomeningitis

Anatomical Context for Lymphocytic Choriomeningitis

MalaCards organs/tissues related to Lymphocytic Choriomeningitis:

39
T Cells, Brain, Spleen, Liver, B Cells, Monocytes, Nk Cells

Publications for Lymphocytic Choriomeningitis

Articles related to Lymphocytic Choriomeningitis:

(show top 50) (show all 556)
id Title Authors Year
1
Development of novel replication-defective lymphocytic choriomeningitis virus vectors expressing SIV antigens. ( 27899229 )
2017
2
Farnesoid X Receptor in Mice Prevents Severe Liver Immunopathology During Lymphocytic Choriomeningitis Virus Infection. ( 28214859 )
2017
3
Visualization of the lymphocytic choriomeningitis mammarenavirus (LCMV) genome reveals the early endosome as a possible site for genome replication and viral particle pre-assembly. ( 28949905 )
2017
4
Congenital Lymphocytic Choriomeningitis Virus: A Case of Prenatal Diagnosis. ( 28858375 )
2017
5
High clinical suspicion of donor-derived disease leads to timely recognition and early intervention to treat solid organ transplant-transmitted lymphocytic choriomeningitis virus. ( 28423464 )
2017
6
Resistance of human plasmacytoid dendritic CAL-1 cells to infection with lymphocytic choriomeningitis virus (LCMV) is caused by restricted virus cell entry, which is overcome by contact of CAL-1 cells with LCMV-infected cells. ( 28843812 )
2017
7
Additive Protection against Congenital Cytomegalovirus Conferred by Combined Glycoprotein B/pp65 Vaccination Using a Lymphocytic Choriomeningitis Virus Vector. ( 27795301 )
2017
8
Microcephaly Caused by Lymphocytic Choriomeningitis Virus. ( 28820372 )
2017
9
Extrinsic Protein Tyrosine Phosphatase Non-Receptor 22 Signals Contribute to CD8 T Cell Exhaustion and Promote Persistence of Chronic Lymphocytic Choriomeningitis Virus Infection. ( 28747914 )
2017
10
T-Cells Underlie Some but Not All of the Cerebellar Pathology in a Neonatal Rat Model of Congenital Lymphocytic Choriomeningitis Virus Infection. ( 27667772 )
2016
11
Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice. ( 27404802 )
2016
12
Notes from the Field: Lymphocytic Choriomeningitis Virus Meningoencephalitis from a Household Rodent Infestation - Minnesota, 2015. ( 26963688 )
2016
13
Lymphocytic choriomeningitis, Ljungan and orthopoxvirus seroconversions in patients hospitalized due to acute Puumala hantavirus infection. ( 27721109 )
2016
14
Lymphocytic choriomeningitis virus: ways to establish and maintain non-cytolytic persistent infection. ( 26982463 )
2016
15
Replication-defective lymphocytic choriomeningitis virus vectors expressing guinea pig cytomegalovirus gB and pp65 homologs are protective against congenital guinea pig cytomegalovirus infection. ( 26973071 )
2016
16
Residues K465 and G467 within the Cytoplasmic Domain of GP2 Play a Critical Role in the Persistence of Lymphocytic Choriomeningitis Virus in Mice. ( 27581982 )
2016
17
Generation of Lymphocytic Choriomeningitis Virus Based Vaccine Vectors. ( 27076310 )
2016
18
Dendritic Cells Are Dispensable for T Cell Priming and Control of Acute Lymphocytic Choriomeningitis Virus Infection. ( 27549169 )
2016
19
Development and application of ELISA for the detection of IgG antibodies to lymphocytic choriomeningitis virus. ( 27265463 )
2016
20
Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana. ( 26631809 )
2016
21
The Lymphocytic Choriomeningitis Virus Matrix Protein PPXY Late Domain Drives the Production of Defective Interfering Particles. ( 27010636 )
2016
22
Peptide motif analysis predicts lymphocytic choriomeningitis virus as trigger for multiple sclerosis. ( 26319106 )
2015
23
Lymphocytic Choriomeningitis Virus Expands a Population of NKG2D+CD8+ T Cells That Exacerbates Disease in Mice Coinfected with Leishmania major. ( 26290604 )
2015
24
Lymphocytic choriomeningitis virus differentially affects virus-induced type I IFN response and mitochondrial apoptosis mediated by RIG-I/MAVS. ( 25833049 )
2015
25
Maternal onset de novo SH2D1A mutation and lymphocytic choriomeningitis virus infection in a patient with Xa89linked lymphoproliferative disease type 1: a case report. ( 25572984 )
2015
26
Lymphocytic choriomeningitis and alpha-chemokines. ( 26152632 )
2015
27
The Nucleoprotein Is Required for Lymphocytic Choriomeningitis Virus-Based Vaccine Vector Immunogenicity. ( 26355095 )
2015
28
Differential Inhibition of Macrophage Activation by Lymphocytic Choriomeningitis Virus and Pichinde Virus Is Mediated by the Z Protein N-Terminal Domain. ( 26423945 )
2015
29
Antiviral Effect of Interferon Lambda Against Lymphocytic Choriomeningitis Virus. ( 25830339 )
2015
30
Lymphocytic choriomeningitis virus infection induced by percutaneous exposure. ( 26416845 )
2015
31
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation-Iowa, 2013. ( 24854024 )
2014
32
Evolution of recombinant lymphocytic choriomeningitis virus/Lassa virus in vivo highlights the importance of the GPC cytosolic tail in viral fitness. ( 24829355 )
2014
33
Protracted Symptoms in Lymphocytic Choriomeningitis: A Case Report. ( 24736119 )
2014
34
Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone. ( 24802239 )
2014
35
Pseudotyping lentiviral vectors with lymphocytic choriomeningitis virus glycoproteins for transduction of dendritic cells and in vivo immunization. ( 25416034 )
2014
36
Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC. ( 25281716 )
2014
37
Lymphocytic choriomeningitis virus persistence promotes effector-like memory differentiation and enhances mucosal T cell distribution. ( 25395301 )
2014
38
Lymphocytic choriomeningitis virus in employees and mice at multipremises feeder-rodent operation, United States, 2012. ( 24447605 )
2014
39
Notes from the field: a cluster of lymphocytic choriomeningitis virus infections transmitted through organ transplantation - Iowa, 2013. ( 24647402 )
2014
40
Human plasmacytoid dendritic cells sense lymphocytic choriomeningitis virus-infected cells in vitro. ( 24155390 )
2014
41
Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes. ( 24928036 )
2014
42
IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. ( 24760883 )
2014
43
Evidence of lymphocytic choriomeningitis virus in domestic mice in Gabon; risk of emergence of LCMV encephalitis in Central Africa. ( 25378495 )
2014
44
Trace-forward investigation of mice in response to lymphocytic choriomeningitis virus outbreak. ( 24447898 )
2014
45
Diseases of the central nervous system caused by lymphocytic choriomeningitis virus and other arenaviruses. ( 25015511 )
2014
46
CD70 deficiency impairs effector CD8 T cell generation and viral clearance but is dispensable for the recall response to lymphocytic choriomeningitis virus. ( 23269247 )
2013
47
Congenital Lymphocytic Choriomeningitis Virus: When to Consider the Diagnosis. ( 23666045 )
2013
48
Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza. ( 23341590 )
2013
49
Lymphocytic choriomeningitis virus infections among American Indians. ( 23460992 )
2013
50
Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? ( 23325690 )
2013

Variations for Lymphocytic Choriomeningitis

Expression for Lymphocytic Choriomeningitis

Search GEO for disease gene expression data for Lymphocytic Choriomeningitis.

Pathways for Lymphocytic Choriomeningitis

Pathways related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.05 ATP6V0B IL6 MYD88
2 10.5 IL6 MYD88

GO Terms for Lymphocytic Choriomeningitis

Biological processes related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.72 AXL CARD14 HNRNPK IL6 MYD88
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 CARD14 IL6 MYD88
3 platelet activation GO:0030168 9.69 AXL IL6 TYRO3
4 viral process GO:0016032 9.65 AXL CLEC4G DAG1 HNRNPK TYRO3
5 substrate adhesion-dependent cell spreading GO:0034446 9.56 AXL TYRO3
6 protein kinase B signaling GO:0043491 9.55 AXL TYRO3
7 apoptotic cell clearance GO:0043277 9.52 AXL TYRO3
8 branching involved in salivary gland morphogenesis GO:0060445 9.49 DAG1 IL6
9 natural killer cell differentiation GO:0001779 9.48 AXL TYRO3
10 secretion by cell GO:0032940 9.46 AXL TYRO3
11 ovulation cycle GO:0042698 9.43 AXL TYRO3
12 vagina development GO:0060068 9.4 AXL TYRO3
13 response to peptidoglycan GO:0032494 9.37 IL6 MYD88
14 forebrain cell migration GO:0021885 9.16 AXL TYRO3
15 negative regulation of lymphocyte activation GO:0051250 8.96 AXL TYRO3
16 viral entry into host cell GO:0046718 8.92 AXL CLEC4G DAG1 TYRO3

Molecular functions related to Lymphocytic Choriomeningitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase binding GO:0043548 8.96 AXL TYRO3
2 virus receptor activity GO:0001618 8.92 AXL CLEC4G DAG1 TYRO3

Sources for Lymphocytic Choriomeningitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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