MCID: LYM042
MIFTS: 41

Lymphocytic Colitis malady

Gastrointestinal diseases, Rare diseases, Immune diseases categories

Summaries for Lymphocytic Colitis

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Lymphocytic colitis, a subtype of microscopic colitis, is a rare condition characterized by chronic... more...

MalaCards: Lymphocytic Colitis, also known as colitis, lymphocytic, is related to collagenous colitis and celiac disease. An important gene associated with Lymphocytic Colitis is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Spinal Cord Injury and AGE/RAGE pathway. The compounds oxyntomodulin and fluoride have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and monocytes, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Lymphocytic Colitis

About this section
Sources:
50Orphanet, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 37MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Immune diseases


Aliases & Descriptions:

lymphocytic colitis 50
colitis, lymphocytic 63


External Ids:

ICD10 via Orphanet27 K52.8
SNOMED-CT via Orphanet60 31437008
UMLS via Orphanet64 C0400822
MESH via Orphanet37 D046730

Related Diseases for Lymphocytic Colitis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Lymphocytic Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1collagenous colitis31.1NOS2
2celiac disease30.6PYY, CD79A
3diarrhea30.4CD79A, CHGA, PYY
4gastritis30.2CHGA, NOS2, CD79A
5microscopic colitis10.2
6inflammatory bowel disease10.2
7psoriasis10.2
8serotonin syndrome10.1PYY, CHGA
9hypertension10.0CD79A, MMP9
10interstitial lung disease10.0MMP9, CD79A
11glucose intolerance10.0PYY, CD79A
12meningitis10.0MMP9, CD79A
13neuroendocrine tumor10.0CHGA, PYY
14mucoepidermoid carcinoma10.0NOS2, CHGA
15peripheral primitive neuroectodermal tumor10.0PYY, CHGA
16focal segmental glomerulosclerosis10.0NOS2, CD79A
17periodontal disease10.0CD79A, MMP9
18carcinoid syndrome10.0PYY, CHGA
19glomerulosclerosis10.0CD79A, NOS2
20cryptosporidiosis10.0
21appendicitis10.0
22autoimmune hepatitis10.0
23ulcerative colitis10.0
24proctitis10.0
25food allergy10.0
26hepatitis10.0
27interstitial nephritis10.0
28collagenous gastritis10.0
29linear iga disease10.0
30satoyoshi syndrome10.0
31nephritis10.0
32blindness10.0
33endotheliitis10.0
34congenital heart disease10.0MMP9, CD79A
35cholera10.0CD79A, PYY
36pancreatic cancer10.0CHGA, MMP9, PYY
37diabetes mellitus10.0CD79A, MMP9, PYY
38glomerulonephritis10.0CD79A, NOS2
39transitional cell carcinoma10.0MMP9, PTGER4
40encephalomyelitis10.0NOS2, PTGER4
41breast cancer10.0MMP9, CHGA, NOS2
42lung cancer10.0CHGA, MMP9, PTGER4
43rheumatoid arthritis10.0CD79A, NOS2, MMP9
44adenoma10.0CHGA, PTGER4, PYY
45tongue squamous cell carcinoma10.0NOS2, CHGA, MMP9
46non-small cell lung carcinoma9.9PTGER4, CHGA
47asthma9.9CD79A, NOS2, MMP9, PTGER4
48colon cancer9.9PYY, PTGER4, MMP9, NOS2
49adenocarcinoma9.8PYY, PTGER4, MMP9, CHGA, NOS2

Graphical network of the top 20 diseases related to Lymphocytic Colitis:



Diseases related to lymphocytic colitis

Symptoms for Lymphocytic Colitis

About this section

Drugs & Therapeutics for Lymphocytic Colitis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Lymphocytic Colitis

Drug clinical trials:

Search ClinicalTrials for Lymphocytic Colitis

Search NIH Clinical Center for Lymphocytic Colitis

Search CenterWatch for Lymphocytic Colitis

Genetic Tests for Lymphocytic Colitis

About this section

Anatomical Context for Lymphocytic Colitis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Lymphocytic Colitis:

34
Colon, Small intestine, Monocytes, Endothelial

Animal Models for Lymphocytic Colitis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Lymphocytic Colitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6MMP9, CHGA, NOS2, CD79A
2MP:00020068.4NOS2, MMP9, PTGER4
3MP:00053858.1PTGER4, MMP9, CHGA, NOS2
4MP:00053908.1NOS2, MMP9, PTGER4, PYY
5MP:00053868.0NOS2, MMP9, PTGER4, PYY
6MP:00053977.8PTGER4, MMP9, NOS2, CD79A
7MP:00053767.3CD79A, NOS2, CHGA, MMP9, PTGER4, PYY

Publications for Lymphocytic Colitis

About this section
Sources:
53PubMed
See all sources

Articles related to Lymphocytic Colitis:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Clinical presentation, diagnosis, pathogenesis and treatment options for lymphocytic colitis (Review). (23695201)
2013
2
Lymphocytic colitis secondary to ipilimumab treatment. (22114048)
2013
3
Macroscopic Findings in Lymphocytic Colitis. (24211291)
2013
4
Letter: are lymphocytic colitis and collagenous colitis really the same disease? (22913854)
2012
5
Cardiac arrest due to lymphocytic colitis: a case report. (22405093)
2012
6
MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis. (22147390)
2012
7
Duloxetine-induced lymphocytic colitis. (22874808)
2012
8
Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. (22699394)
2012
9
High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. (23155335)
2012
10
Pediatric lymphocytic colitis presenting with intractable diarrhea. (21543998)
2011
11
Unique endoscopic findings in lymphocytic colitis. (22305502)
2011
12
Evolution of the incidence of collagenous colitis and lymphocytic colitis in Terrassa, Spain: a population-based study. (20878755)
2011
13
Lymphocytic colitis in Satoyoshi syndrome. (20710153)
2010
14
Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. (20809338)
2010
15
Lymphocytic colitis under treatment with duloxetine. (20517807)
2010
16
Lymphocytic colitis presenting as difficult diarrhoea in an African woman: a case report and review of the literature. (20205879)
2010
17
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study. (19352342)
2009
18
Collagenous and lymphocytic colitis: systematic review and update of the literature. (20203510)
2009
19
Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study. (19303012)
2009
20
Pitfalls and errors in the diagnosis of collagenous and lymphocytic colitis. (21172236)
2008
21
Interventions for treating lymphocytic colitis. (18425936)
2008
22
Lymphocytic colitis. (17693240)
2007
23
Lymphocytic colitis: a clue to bacterial etiology. (16437626)
2005
24
Seasonal pattern of onset in lymphocytic colitis. (16208113)
2005
25
Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients. (15016748)
2004
26
Luminal nitric oxide and epithelial expression of inducible and endothelial nitric oxide synthase in collagenous and lymphocytic colitis. (12608467)
2003
27
Lymphocytic colitis: clinical features, treatment, and outcomes. (12425555)
2002
28
Lymphocytic colitis treated with proctocolectomy and ileal J-pouch-anal anastomosis: report of a case. (11786777)
2002
29
Cryptal lymphocytic coloproctitis: a new phenotype of lymphocytic colitis? (11865010)
2002
30
Azathioprine as a treatment of refractory lymphocytic colitis. (11338080)
2001
31
Familial occurrence of lymphocytic colitis. (11727006)
2001
32
Cryptal lymphocytic colitis: a new entity in baboons. (10945162)
2000
33
Prevalence of celiac disease in collagenous and lymphocytic colitis. (11125181)
2000
34
Colonic epithelial lymphocytosis and lymphocytic colitis: descriptive histopathology versus distinct clinicopathologic entities. (10907806)
2000
35
Acarbose and lymphocytic colitis. (11072952)
2000
36
Lymphocytic colitis: a clue to an infectious trigger. (10048742)
1999
37
Lymphocytic colitis, induced by ticlopidine. (10604225)
1999
38
Incidence of collagenous and lymphocytic colitis: a 5-year population-based study. (10022639)
1999
39
Hyposplenism, antiendomysial antibodies and lymphocytic colitis in collagenous sprue. (10360997)
1999
40
Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis. (10446105)
1999
41
Linear IgA disease associated with lymphocytic colitis. (10233230)
1999
42
Lymphocytic colitis: clinical presentation and long term course. (9824342)
1998
43
Failure of added dietary gluten to induce small intestinal histopathological changes in patients with watery diarrhea and lymphocytic colitis. (9113884)
1996
44
Collagenous gastritis associated with lymphocytic colitis. (8742654)
1996
45
Immunohistological study of IgA, IgG and IgM in endoscopic biopsies of dogs with plasmacytic-lymphocytic colitis. (9011157)
1996
46
Are collagenous colitis and lymphocytic colitis distinct syndromes? (8542665)
1995
47
Ranitidine, diarrhoea, and lymphocytic colitis. (8549950)
1995
48
Collagenous, microscopic and lymphocytic colitis. An evolving concept. (8055150)
1994
49
Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. (1551336)
1992
50
Plasmacytic lymphocytic colitis in the dog. (2629052)
1989

Variations for Lymphocytic Colitis

About this section

Expression for genes affiliated with Lymphocytic Colitis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphocytic Colitis

Search GEO for disease gene expression data for Lymphocytic Colitis.

Pathways for genes affiliated with Lymphocytic Colitis

About this section
Sources:
51PathCards, 39NCBI BioSystems Database, 54QIAGEN, 52PharmGKB
See all sources

Pathways related to Lymphocytic Colitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3NOS2, MMP9
29.3NOS2, MMP9
39.1MMP9, PTGER4
49.1MMP9, PTGER4

Compounds for genes affiliated with Lymphocytic Colitis

About this section
Sources:
46Novoseek, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank, 3BitterDB
See all sources

Compounds related to Lymphocytic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1oxyntomodulin46 6210.9CHGA, PYY
2fluoride469.9CHGA, CD79A
3anti-fungal469.9CD79A, CHGA
4omeprazole46 52 30 25 1213.9PYY, CHGA
5clonidine46 52 30 1212.8CHGA, PYY
6isoniazid46 52 1211.8CD79A, NOS2
7ivig469.8MMP9, CD79A
8octreotide46 62 30 1212.7PYY, CHGA
9minocycline46 1210.7NOS2, MMP9
10ciglitazone46 3010.7NOS2, MMP9
11parthenolide46 310.7NOS2, MMP9
12doxycycline46 1210.7MMP9, CD79A
13silymarin469.7MMP9, NOS2
14alpha lipoic acid469.7MMP9, NOS2
15hematoxylin469.7MMP9, CHGA
16misoprostol46 1210.7CHGA, PTGER4
17l-nmma469.6MMP9, NOS2
18c-peptide469.6PYY, CHGA
19propranolol46 30 52 25 1213.5CHGA, PYY
20carbachol46 30 1211.5CD79A, CHGA, PYY
21inositol469.5MMP9, CHGA, CD79A
22theophylline46 30 25 1212.5CD79A, CHGA
23formaldehyde46 2510.5CD79A, CHGA, MMP9
24epinephrine46 25 1211.5MMP9, CHGA, CD79A
25fluvastatin46 52 30 1212.5NOS2, MMP9
26fibrinogen469.5CD79A, CHGA, MMP9
27histamine46 30 2511.4PYY, CHGA, CD79A
28gaba469.4PYY, MMP9, CHGA
29lactate469.4CD79A, CHGA, MMP9
30creatinine469.4CD79A, CHGA, MMP9
31isoproterenol46 1210.3NOS2, CHGA, PYY
32n acetylcysteine469.3CD79A, NOS2, MMP9
33cycloheximide469.1NOS2, CHGA, MMP9
34celecoxib46 62 30 52 25 1214.0NOS2, MMP9
35norepinephrine46 25 1211.0CD79A, CHGA, MMP9, PYY
36dopamine46 30 25 1212.0PYY, MMP9, CHGA, CD79A
37cyclic amp46 2510.0CHGA, PTGER4, PYY
38indomethacin46 30 62 1212.0PTGER4, NOS2, CD79A
39ns 39846 6210.0PTGER4, MMP9, NOS2
40acetylcholine46 52 30 25 1212.9PYY, CHGA, NOS2, CD79A
41arginine468.9PYY, CHGA, NOS2, CD79A
42glutamate468.9CD79A, NOS2, CHGA, MMP9
43paraffin468.7PTGER4, MMP9, CHGA, CD79A
44adenylate468.5PTGER4, MMP9, CHGA, NOS2
45pge2468.5CD79A, NOS2, MMP9, PTGER4
46tyrosine468.2PYY, PTGER4, MMP9, CHGA
47dexamethasone46 52 30 1211.1PTGER4, MMP9, CHGA, NOS2, CD79A
48vegf468.1CD79A, NOS2, CHGA, MMP9, PTGER4
49calcium46 52 25 1211.0NOS2, CHGA, MMP9, PTGER4, PYY
50estrogen467.6CD79A, NOS2, CHGA, MMP9, PTGER4, PYY

GO Terms for genes affiliated with Lymphocytic Colitis

About this section

Products for genes affiliated with Lymphocytic Colitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphocytic Colitis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet