MCID: LYM042
MIFTS: 41

Lymphocytic Colitis malady

Gastrointestinal diseases, Rare diseases, Immune diseases categories
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Summaries for Lymphocytic Colitis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Lymphocytic colitis, a subtype of microscopic colitis, is a rare condition characterized by chronic... more...

MalaCards: Lymphocytic Colitis, also known as colitis, lymphocytic, is related to collagenous colitis and celiac disease. An important gene associated with Lymphocytic Colitis is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Spinal Cord Injury and AGE/RAGE pathway. The compounds oxyntomodulin and fluoride have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and monocytes, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Aliases & Classifications for Lymphocytic Colitis

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Sources:
49Orphanet, 62UMLS, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Immune diseases


Aliases & Descriptions:

lymphocytic colitis 49
colitis, lymphocytic 62


External Ids:

ICD10 via Orphanet26 K52.8
SNOMED-CT via Orphanet59 31437008
UMLS via Orphanet63 C0400822
MESH via Orphanet36 D046730

Related Diseases for Lymphocytic Colitis

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17GeneCards, 18GeneDecks
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Diseases related to Lymphocytic Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1collagenous colitis31.1NOS2
2celiac disease30.6PYY, CD79A
3diarrhea30.4CD79A, CHGA, PYY
4gastritis30.2CHGA, NOS2, CD79A
5microscopic colitis10.2
6inflammatory bowel disease10.2
7psoriasis10.2
8serotonin syndrome10.1PYY, CHGA
9hypertension10.0CD79A, MMP9
10interstitial lung disease10.0MMP9, CD79A
11glucose intolerance10.0PYY, CD79A
12meningitis10.0MMP9, CD79A
13neuroendocrine tumor10.0CHGA, PYY
14mucoepidermoid carcinoma10.0NOS2, CHGA
15peripheral primitive neuroectodermal tumor10.0PYY, CHGA
16focal segmental glomerulosclerosis10.0NOS2, CD79A
17periodontal disease10.0CD79A, MMP9
18carcinoid syndrome10.0PYY, CHGA
19glomerulosclerosis10.0CD79A, NOS2
20cryptosporidiosis10.0
21appendicitis10.0
22autoimmune hepatitis10.0
23ulcerative colitis10.0
24proctitis10.0
25food allergy10.0
26hepatitis10.0
27interstitial nephritis10.0
28collagenous gastritis10.0
29linear iga disease10.0
30satoyoshi syndrome10.0
31nephritis10.0
32blindness10.0
33endotheliitis10.0
34congenital heart disease10.0MMP9, CD79A
35cholera10.0CD79A, PYY
36pancreatic cancer10.0CHGA, MMP9, PYY
37diabetes mellitus10.0CD79A, MMP9, PYY
38glomerulonephritis10.0CD79A, NOS2
39transitional cell carcinoma10.0MMP9, PTGER4
40encephalomyelitis10.0NOS2, PTGER4
41breast cancer10.0MMP9, CHGA, NOS2
42lung cancer10.0CHGA, MMP9, PTGER4
43rheumatoid arthritis10.0CD79A, NOS2, MMP9
44adenoma10.0CHGA, PTGER4, PYY
45tongue squamous cell carcinoma10.0NOS2, CHGA, MMP9
46non-small cell lung carcinoma9.9PTGER4, CHGA
47asthma9.9CD79A, NOS2, MMP9, PTGER4
48colon cancer9.9PYY, PTGER4, MMP9, NOS2
49adenocarcinoma9.8PYY, PTGER4, MMP9, CHGA, NOS2

Graphical network of the top 20 diseases related to Lymphocytic Colitis:



Diseases related to lymphocytic colitis

Symptoms for Lymphocytic Colitis

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Drugs & Therapeutics for Lymphocytic Colitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Lymphocytic Colitis

Search NIH Clinical Center for Lymphocytic Colitis

Genetic Tests for Lymphocytic Colitis

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Anatomical Context for Lymphocytic Colitis

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33MalaCards
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MalaCards organs/tissues related to Lymphocytic Colitis:

33
Colon, Small intestine, Monocytes, Endothelial

Animal Models for Lymphocytic Colitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lymphocytic Colitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6MMP9, CHGA, NOS2, CD79A
2MP:00020068.4NOS2, MMP9, PTGER4
3MP:00053858.1PTGER4, MMP9, CHGA, NOS2
4MP:00053908.1NOS2, MMP9, PTGER4, PYY
5MP:00053868.0NOS2, MMP9, PTGER4, PYY
6MP:00053977.8PTGER4, MMP9, NOS2, CD79A
7MP:00053767.3CD79A, NOS2, CHGA, MMP9, PTGER4, PYY

Publications for Lymphocytic Colitis

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52PubMed
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Articles related to Lymphocytic Colitis:

(show top 50)    (show all 100)
idTitleAuthorsYear
1
Clinical presentation, diagnosis, pathogenesis and treatment options for lymphocytic colitis (Review). (23695201)
2013
2
Lymphocytic colitis secondary to ipilimumab treatment. (22114048)
2013
3
Macroscopic Findings in Lymphocytic Colitis. (24211291)
2013
4
Letter: are lymphocytic colitis and collagenous colitis really the same disease? (22913854)
2012
5
Cardiac arrest due to lymphocytic colitis: a case report. (22405093)
2012
6
MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis. (22147390)
2012
7
Duloxetine-induced lymphocytic colitis. (22874808)
2012
8
Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. (22699394)
2012
9
High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. (23155335)
2012
10
Pediatric lymphocytic colitis presenting with intractable diarrhea. (21543998)
2011
11
Unique endoscopic findings in lymphocytic colitis. (22305502)
2011
12
Evolution of the incidence of collagenous colitis and lymphocytic colitis in Terrassa, Spain: a population-based study. (20878755)
2011
13
Lymphocytic colitis in Satoyoshi syndrome. (20710153)
2010
14
Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. (20809338)
2010
15
Lymphocytic colitis under treatment with duloxetine. (20517807)
2010
16
Lymphocytic colitis presenting as difficult diarrhoea in an African woman: a case report and review of the literature. (20205879)
2010
17
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study. (19352342)
2009
18
Collagenous and lymphocytic colitis: systematic review and update of the literature. (20203510)
2009
19
Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study. (19303012)
2009
20
Pitfalls and errors in the diagnosis of collagenous and lymphocytic colitis. (21172236)
2008
21
Interventions for treating lymphocytic colitis. (18425936)
2008
22
Lymphocytic colitis. (17693240)
2007
23
Lymphocytic colitis: a clue to bacterial etiology. (16437626)
2005
24
Seasonal pattern of onset in lymphocytic colitis. (16208113)
2005
25
Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients. (15016748)
2004
26
Luminal nitric oxide and epithelial expression of inducible and endothelial nitric oxide synthase in collagenous and lymphocytic colitis. (12608467)
2003
27
Lymphocytic colitis: clinical features, treatment, and outcomes. (12425555)
2002
28
Lymphocytic colitis treated with proctocolectomy and ileal J-pouch-anal anastomosis: report of a case. (11786777)
2002
29
Cryptal lymphocytic coloproctitis: a new phenotype of lymphocytic colitis? (11865010)
2002
30
Azathioprine as a treatment of refractory lymphocytic colitis. (11338080)
2001
31
Familial occurrence of lymphocytic colitis. (11727006)
2001
32
Cryptal lymphocytic colitis: a new entity in baboons. (10945162)
2000
33
Prevalence of celiac disease in collagenous and lymphocytic colitis. (11125181)
2000
34
Colonic epithelial lymphocytosis and lymphocytic colitis: descriptive histopathology versus distinct clinicopathologic entities. (10907806)
2000
35
Acarbose and lymphocytic colitis. (11072952)
2000
36
Lymphocytic colitis: a clue to an infectious trigger. (10048742)
1999
37
Lymphocytic colitis, induced by ticlopidine. (10604225)
1999
38
Incidence of collagenous and lymphocytic colitis: a 5-year population-based study. (10022639)
1999
39
Hyposplenism, antiendomysial antibodies and lymphocytic colitis in collagenous sprue. (10360997)
1999
40
Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis. (10446105)
1999
41
Linear IgA disease associated with lymphocytic colitis. (10233230)
1999
42
Lymphocytic colitis: clinical presentation and long term course. (9824342)
1998
43
Failure of added dietary gluten to induce small intestinal histopathological changes in patients with watery diarrhea and lymphocytic colitis. (9113884)
1996
44
Collagenous gastritis associated with lymphocytic colitis. (8742654)
1996
45
Immunohistological study of IgA, IgG and IgM in endoscopic biopsies of dogs with plasmacytic-lymphocytic colitis. (9011157)
1996
46
Are collagenous colitis and lymphocytic colitis distinct syndromes? (8542665)
1995
47
Ranitidine, diarrhoea, and lymphocytic colitis. (8549950)
1995
48
Collagenous, microscopic and lymphocytic colitis. An evolving concept. (8055150)
1994
49
Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. (1551336)
1992
50
Plasmacytic lymphocytic colitis in the dog. (2629052)
1989

Variations for Lymphocytic Colitis

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Expression for genes affiliated with Lymphocytic Colitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphocytic Colitis

Search GEO for disease gene expression data for Lymphocytic Colitis.

Pathways for genes affiliated with Lymphocytic Colitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 53QIAGEN, 51PharmGKB
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Pathways related to Lymphocytic Colitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3NOS2, MMP9
29.3NOS2, MMP9
39.1MMP9, PTGER4
49.1MMP9, PTGER4

Compounds for genes affiliated with Lymphocytic Colitis

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Sources:
45Novoseek, 61Tocris Bioscience, 51PharmGKB, 29IUPHAR, 24HMDB, 11DrugBank, 3BitterDB
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Compounds related to Lymphocytic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1oxyntomodulin45 6110.9CHGA, PYY
2fluoride459.9CHGA, CD79A
3anti-fungal459.9CD79A, CHGA
4omeprazole45 51 29 24 1113.9PYY, CHGA
5clonidine45 51 29 1112.8CHGA, PYY
6isoniazid45 51 1111.8CD79A, NOS2
7ivig459.8MMP9, CD79A
8octreotide45 61 29 1112.7PYY, CHGA
9minocycline45 1110.7NOS2, MMP9
10ciglitazone45 2910.7NOS2, MMP9
11parthenolide45 310.7NOS2, MMP9
12doxycycline45 1110.7MMP9, CD79A
13silymarin459.7MMP9, NOS2
14alpha lipoic acid459.7MMP9, NOS2
15hematoxylin459.7MMP9, CHGA
16misoprostol45 1110.7CHGA, PTGER4
17l-nmma459.6MMP9, NOS2
18c-peptide459.6PYY, CHGA
19propranolol45 29 51 24 1113.5CHGA, PYY
20carbachol45 29 1111.5CD79A, CHGA, PYY
21inositol459.5MMP9, CHGA, CD79A
22theophylline45 29 24 1112.5CD79A, CHGA
23formaldehyde45 2410.5CD79A, CHGA, MMP9
24epinephrine45 24 1111.5MMP9, CHGA, CD79A
25fluvastatin45 51 29 1112.5NOS2, MMP9
26fibrinogen459.5CD79A, CHGA, MMP9
27histamine45 29 2411.4PYY, CHGA, CD79A
28gaba459.4PYY, MMP9, CHGA
29lactate459.4CD79A, CHGA, MMP9
30creatinine459.4CD79A, CHGA, MMP9
31isoproterenol45 1110.3NOS2, CHGA, PYY
32n acetylcysteine459.3CD79A, NOS2, MMP9
33cycloheximide459.1NOS2, CHGA, MMP9
34celecoxib45 61 29 51 24 1114.0NOS2, MMP9
35norepinephrine45 24 1111.0CD79A, CHGA, MMP9, PYY
36dopamine45 29 24 1112.0PYY, MMP9, CHGA, CD79A
37cyclic amp45 2410.0CHGA, PTGER4, PYY
38indomethacin45 29 61 1112.0PTGER4, NOS2, CD79A
39ns 39845 6110.0PTGER4, MMP9, NOS2
40acetylcholine45 51 29 24 1112.9PYY, CHGA, NOS2, CD79A
41arginine458.9PYY, CHGA, NOS2, CD79A
42glutamate458.9CD79A, NOS2, CHGA, MMP9
43paraffin458.7PTGER4, MMP9, CHGA, CD79A
44adenylate458.5PTGER4, MMP9, CHGA, NOS2
45pge2458.5CD79A, NOS2, MMP9, PTGER4
46tyrosine458.2PYY, PTGER4, MMP9, CHGA
47dexamethasone45 51 29 1111.1PTGER4, MMP9, CHGA, NOS2, CD79A
48vegf458.1CD79A, NOS2, CHGA, MMP9, PTGER4
49calcium45 51 24 1111.0NOS2, CHGA, MMP9, PTGER4, PYY
50estrogen457.6CD79A, NOS2, CHGA, MMP9, PTGER4, PYY

GO Terms for genes affiliated with Lymphocytic Colitis

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Products for genes affiliated with Lymphocytic Colitis

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Sources for Lymphocytic Colitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet