MCID: LYM042
MIFTS: 36

Lymphocytic Colitis malady

Categories: Rare diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Colitis

Aliases & Descriptions for Lymphocytic Colitis:

Name: Lymphocytic Colitis 12 50 14
Colitis, Lymphocytic 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060184
ICD10 33 K52.89
MeSH 42 D046730
NCIt 47 C27147
SNOMED-CT 64 31437008
UMLS 69 C0400822

Summaries for Lymphocytic Colitis

NIH Rare Diseases : 50 lymphocytic colitis is form of microscopic colitis, a condition that is characterized by inflammation of the colon (large intestines). as the name suggests, microscopic colitis can only be diagnosed by examining a small sample of colon tissue under a microscope. in lymphocytic colitis, specifically, the tissues and lining of the colon are of normal thickness, but an increase in the number of lymphocytes (a type of white blood cell) is observed. signs and symptoms of the condition may include chronic, watery diarrhea; abdominal pain, cramping, and bloating; weight loss; nausea; dehydration; and/or fecal incontinence. the underlying cause of lymphocytic colitis is currently unknown; however, scientists suspect that autoimmune conditions, medications, infections, genetic factors, and/or bile acid malabsorption may contribute to the development of the condition. treatment is based on the signs and symptoms present in each person and may include certain medications, dietary modifications, and in rare cases, surgery. last updated: 4/6/2016

MalaCards based summary : Lymphocytic Colitis, also known as colitis, lymphocytic, is related to diversion colitis and collagenous colitis. An important gene associated with Lymphocytic Colitis is CHGA (Chromogranin A), and among its related pathways/superpathways are NF-kappaB Signaling and Celecoxib Pathway, Pharmacodynamics. The drugs Budesonide and Anti-Asthmatic Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, monocytes and endothelial, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria).

Wikipedia : 71 Lymphocytic colitis is a subtype of microscopic colitis, a condition characterized by chronic non-bloody... more...

Related Diseases for Lymphocytic Colitis

Diseases related to Lymphocytic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Related Disease Score Top Affiliating Genes
1 diversion colitis 27.6 ATP4A CD79A CD8A CHGA IRAK2 MMP9
2 collagenous colitis 11.2
3 microscopic colitis 11.2
4 colitis 10.5
5 renal pelvis adenocarcinoma 10.2 CHGA PTGER4
6 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA MMP9
7 cardioauditory syndrome of sanchez cascos 10.2 CHGA PYY
8 secondary syphilis 10.2 ATP4A CHGA
9 brain edema 10.2 ATP4A CHGA
10 mesenteric vascular occlusion 10.1 ATP4A PYY
11 autoimmune polyendocrine syndrome type 1 10.1 CD8A MMP9
12 hepatitis b reinfection following liver transplantation 10.1 CHGA PYY
13 scrotum melanoma 10.1 ATP4A CD8A
14 scrotum squamous cell carcinoma 10.1 ATP4A CD8A
15 breast adenomyoepithelioma 10.1 CD8A MMP9
16 chemical colitis 10.1 CD79A CHGA
17 toxic optic neuropathy 10.0 CD79A MMP9
18 cellulitis 10.0 CD79A MMP9
19 viral meningitis 10.0 CD79A MMP9
20 isthmus cancer 10.0 CD79A MMP9
21 colloid adenoma 10.0 CD79A CD8A
22 mild pre-eclampsia 10.0 CD79A CD8A
23 retinal microaneurysm 10.0 CD79A CD8A
24 postcricoid region cancer 10.0 CD79A CD8A
25 amyotrophic lateral sclerosis type 10 10.0 ATP4A CD79A
26 omsk hemorrhagic fever 10.0 CD79A MMP9
27 vein disease 10.0 ATP4A CD79A
28 primary thrombocytopenia 10.0 CD79A CD8A
29 pneumocystosis 10.0 CD79A CD8A
30 dysentery 10.0 CD79A CD8A
31 dysplastic nevus syndrome 10.0 CD79A CD8A
32 abducens nerve disease 10.0 CD79A CD8A
33 gastroduodenal crohn's disease 10.0 ATP4A CD79A
34 perinatal necrotizing enterocolitis 10.0 CD79A CD8A
35 tularemia 10.0 CD79A CD8A
36 rosacea conjunctivitis 10.0 CD79A CD8A
37 gluten allergy 10.0 CD79A CD8A
38 chronic subinvolution of uterus 10.0 CD79A CD8A
39 oral cavity cancer 10.0 CD79A CD8A
40 inclusion conjunctivitis 9.9 CD79A CD8A
41 autonomic peripheral neuropathy 9.9 CD79A CD8A
42 squamous cell papilloma of skin 9.9 CD79A CD8A
43 red-green color blindness 9.9 CD79A CD8A
44 brain germinoma 9.9 CD79A CD8A
45 newcastle disease 9.9 CD79A CD8A
46 celiac disease 9.9
47 autoimmune disease of skin and connective tissue 9.9 CD79A CD8A
48 motor peripheral neuropathy 9.9 CD79A CD8A
49 childhood intracortical osteosarcoma 9.8 ATP4A CD79A
50 nonspecific interstitial pneumonia 9.8 CD79A CD8A

Graphical network of the top 20 diseases related to Lymphocytic Colitis:



Diseases related to Lymphocytic Colitis

Symptoms & Phenotypes for Lymphocytic Colitis

MGI Mouse Phenotypes related to Lymphocytic Colitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.63 ATP4A CD79A CD8A IRAK2 MMP9 PTGER4
2 homeostasis/metabolism MP:0005376 9.5 ATP4A CD79A CHGA IRAK2 MMP9 PTGER4
3 immune system MP:0005387 9.1 ATP4A CD79A CD8A IRAK2 MMP9 PTGER4

Drugs & Therapeutics for Lymphocytic Colitis

Drugs for Lymphocytic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Phase 2 51333-22-3 63006 5281004
2 Anti-Asthmatic Agents Phase 3,Phase 2
3 Anti-Inflammatory Agents Phase 3,Phase 2
4 Autonomic Agents Phase 3,Phase 2
5 Bronchodilator Agents Phase 3,Phase 2
6 glucocorticoids Phase 3,Phase 2
7 Hormone Antagonists Phase 3,Phase 2
8 Hormones Phase 3,Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
10 Peripheral Nervous System Agents Phase 3,Phase 2
11 Respiratory System Agents Phase 3,Phase 2
12 Analgesics Phase 3
13 Analgesics, Non-Narcotic Phase 3
14 Anti-Inflammatory Agents, Non-Steroidal Phase 3
15 Antirheumatic Agents Phase 3
16 Mesalamine Phase 3 89-57-6
17
Idelalisib Approved 870281-82-6
18 Pharmaceutical Solutions
19 Antacids
20 Anti-Ulcer Agents
21
Bismuth 7440-69-9 16682734 105143
22 Gastrointestinal Agents
23 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3
2 Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis Recruiting NCT01209208 Phase 3
3 Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3
4 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
5 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Recruiting NCT01504048
6 Mechanisms of Idelalisib-Associated Diarrhea in Patients With Relapsed Chronic Lymphocytic Leukemia, Indolent Non-hodgkin Lymphoma, or Small Lymphocytic Lymphoma Not yet recruiting NCT02928510
7 Treatment of Microscopic Colitis Terminated NCT00184171

Search NIH Clinical Center for Lymphocytic Colitis

Cochrane evidence based reviews: colitis, lymphocytic

Genetic Tests for Lymphocytic Colitis

Anatomical Context for Lymphocytic Colitis

MalaCards organs/tissues related to Lymphocytic Colitis:

39
Colon, Monocytes, Endothelial, Small Intestine

Publications for Lymphocytic Colitis

Articles related to Lymphocytic Colitis:

(show top 50) (show all 112)
id Title Authors Year
1
ENaC Dysregulation Through Activation of MEK1/2 Contributes to Impaired Na+ Absorption in Lymphocytic Colitis. ( 26658215 )
2016
2
Bullous Pemphigoid with Lymphocytic Colitis: A Case Report and Short Literature Review. ( 27469343 )
2016
3
HLA Associations Distinguish Collagenous From Lymphocytic Colitis. ( 27481432 )
2016
4
Cat Scratch Colon in a Patient With Lymphocytic Colitis. ( 27580771 )
2016
5
CD3 immunohistochemical staining in diagnosis of lymphocytic colitis. ( 26772395 )
2016
6
Microscopic colitis: a descriptive clinical cohort study of 795 patients with collagenous and lymphocytic colitis. ( 26679722 )
2016
7
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
8
Lymphocytic colitis complicated by a mass in the terminal ileum. ( 26034326 )
2015
9
Association of lymphocytic colitis and lactase deficiency in pediatric population. ( 25523228 )
2015
10
Clinical characteristics and patterns and predictors of response to therapy in collagenous and lymphocytic colitis. ( 25997458 )
2015
11
Does Lymphocytic Colitis Always Present with Normal Endoscopic Findings? ( 25167800 )
2014
12
Cryptosporidiosis-associated lymphocytic colitis. ( 23912411 )
2013
13
Stable incidence of collagenous colitis and lymphocytic colitis in A9rebro, Sweden, 1999-2008: a continuous epidemiologic study. ( 23945183 )
2013
14
Clinical presentation, diagnosis, pathogenesis and treatment options for lymphocytic colitis (Review). ( 23695201 )
2013
15
In vivo diagnosis of lymphocytic colitis by confocal laser endomicroscopy. ( 22851663 )
2013
16
Macroscopic Findings in Lymphocytic Colitis. ( 24211291 )
2013
17
Lymphocytic colitis secondary to ipilimumab treatment. ( 22114048 )
2013
18
Lymphocytic colitis is associated with increased pro-inflammatory cytokine profile and up regulation of prostaglandin receptor EP4. ( 23613969 )
2013
19
Cardiac arrest due to lymphocytic colitis: a case report. ( 22405093 )
2012
20
High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. ( 23155335 )
2012
21
Lymphocytic colitis and collagenous colitis: a review of clinicopathologic features and immunologic abnormalities. ( 22156832 )
2012
22
MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis. ( 22147390 )
2012
23
The behavior of matrix metalloproteinase-9 in lymphocytic colitis, collagenous colitis and ulcerative colitis. ( 21678108 )
2012
24
The various faces of autoimmune endocrinopathies: non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis. ( 23043903 )
2012
25
Duloxetine-induced lymphocytic colitis. ( 22874808 )
2012
26
Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. ( 22699394 )
2012
27
Letter: are lymphocytic colitis and collagenous colitis really the same disease? ( 22913854 )
2012
28
Systematic review: are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis? ( 22670660 )
2012
29
Are collagenous and lymphocytic colitis different aspects of the same disease? ( 23016916 )
2012
30
Unique endoscopic findings in lymphocytic colitis. ( 22305502 )
2011
31
Pediatric lymphocytic colitis presenting with intractable diarrhea. ( 21543998 )
2011
32
High chromogranin A cell density in the colon of patients with lymphocytic colitis. ( 21584496 )
2011
33
Evolution of the incidence of collagenous colitis and lymphocytic colitis in Terrassa, Spain: a population-based study. ( 20878755 )
2011
34
Lymphocytic colitis under treatment with duloxetine. ( 20517807 )
2010
35
Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. ( 20809338 )
2010
36
Lymphocytic colitis presenting as difficult diarrhoea in an African woman: a case report and review of the literature. ( 20205879 )
2010
37
A retrospective study on a cohort of patients with lymphocytic colitis. ( 20575599 )
2010
38
Lymphocytic colitis in Satoyoshi syndrome. ( 20710153 )
2010
39
Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study. ( 19303012 )
2009
40
Collagenous and lymphocytic colitis: systematic review and update of the literature. ( 20203510 )
2009
41
Enterocolic lymphocytic phlebitis and lymphocytic colitis: drug-related coexistent pathology. ( 18758788 )
2009
42
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study. ( 19352342 )
2009
43
Nodular lymphoid hyperplasia and histologic changes mimicking celiac disease, collagenous sprue, and lymphocytic colitis in a patient with selective IgA deficiency. ( 19286327 )
2009
44
Large intestine: Remission of lymphocytic colitis with budesonide. ( 19713982 )
2009
45
Oral pH-modified release budesonide for treatment of inflammatory bowel disease, collagenous and lymphocytic colitis. ( 18422482 )
2008
46
Interventions for treating lymphocytic colitis. ( 18425936 )
2008
47
Pitfalls and errors in the diagnosis of collagenous and lymphocytic colitis. ( 21172236 )
2008
48
Reduced watery diarrhea during pregnancy in a psoriasis patient with lymphocytic colitis. ( 19012199 )
2008
49
Lymphocytic colitis in a child with non-responsive celiac disease. ( 19317281 )
2008
50
Lymphocytic colitis. ( 17693240 )
2007

Variations for Lymphocytic Colitis

Expression for Lymphocytic Colitis

Search GEO for disease gene expression data for Lymphocytic Colitis.

Pathways for Lymphocytic Colitis

Pathways related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.63 CD79A CD8A IRAK2
2 10.92 MMP9 PTGER4
3 10.19 CD79A CD8A

GO Terms for Lymphocytic Colitis

Biological processes related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 JNK cascade GO:0007254 8.62 IRAK2 PTGER4

Sources for Lymphocytic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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