MCID: LYM042
MIFTS: 34

Lymphocytic Colitis malady

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Colitis

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Aliases & Descriptions for Lymphocytic Colitis:

Name: Lymphocytic Colitis 11 46 13
 
Colitis, Lymphocytic 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:0060184
ICD1028 K52.89
SNOMED-CT60 31437008
MeSH37 D046730
NCIt43 C27147

Summaries for Lymphocytic Colitis

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NIH Rare Diseases:46 Lymphocytic colitis is form of microscopic colitis, a condition that is characterized by inflammation of the colon (large intestines). as the name suggests, microscopic colitis can only be diagnosed by examining a small sample of colon tissue under a microscope. in lymphocytic colitis, specifically, the tissues and lining of the colon are of normal thickness, but an increase in the number of lymphocytes (a type of white blood cell) is observed. signs and symptoms of the condition may include chronic, watery diarrhea; abdominal pain, cramping, and bloating; weight loss; nausea; dehydration; and/or fecal incontinence. the underlying cause of lymphocytic colitis is currently unknown; however, scientists suspect that autoimmune conditions, medications, infections, genetic factors, and/or bile acid malabsorption may contribute to the development of the condition. treatment is based on the signs and symptoms present in each person and may include certain medications, dietary modifications, and in rare cases, surgery. last updated: 4/6/2016

MalaCards based summary: Lymphocytic Colitis, also known as colitis, lymphocytic, is related to diarrhea and collagenous colitis. An important gene associated with Lymphocytic Colitis is CHGA (Chromogranin A), and among its related pathways is Celecoxib Pathway, Pharmacodynamics. Affiliated tissues include colon, endothelial and monocytes, and related mouse phenotypes are neoplasm and renal/urinary system.

Disease Ontology:11 A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria).

Wikipedia:69 Lymphocytic colitis is a subtype of microscopic colitis, a condition characterized by chronic non-bloody... more...

Related Diseases for Lymphocytic Colitis

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Diseases related to Lymphocytic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1diarrhea30.2ATP4A, PYY
2collagenous colitis10.7
3colitis10.6
4microscopic colitis10.5
5esophagus adenocarcinoma10.5CHGA, PTGER4
6carcinoma of the vocal tract10.4CHGA, PYY
7microglandular adenosis of breast10.4CHGA, MMP9
8pancreatic cystadenocarcinoma10.3ATP4A, PYY
9clostridium difficile colitis10.3CD79A, CHGA
10diabetic cataract10.3CD79A, MMP9
11sialadenitis10.2CD79A, MMP9
12plague10.2CD79A, MMP9
13meibomian cyst10.2CD79A, MMP9
14subacute delirium10.2ATP4A, CD79A
15ileocolitis10.2ATP4A, CD79A
16histidine metabolism disease10.1CD79A, MMP9
17integumentary system cancer10.1CD79A, MMP9
18nervous system cancer10.1CD79A, MMP9
19eosinophilic gastritis10.0ATP4A, CHGA
20brown-vialetto-van laere syndrome10.0CHGA, MMP9
21celiac disease10.0
22laryngeal tuberculosis10.0CD79A, MMP9
23zellweger-like syndrome without peroxisomal anomalies10.0MMP9, TGM2
24cutaneous t cell lymphoma9.9CD79A, TGM2
25amyotrophic lateral sclerosis type 29.9ATP4A, TGM2
26intracortical osteogenic sarcoma9.9ATP4A, CD79A, CHGA
27b cell linker protein deficiency9.9CD79A, TGM2
28bulbar polio9.9CHGA, TGM2
29autism spectrum disorder9.8CD79A, TGM2
30gastritis9.8
31perianal skin paget's disease9.8ATP4A, CD79A
32impetigo9.8CD79A, TGM2
33mast cell neoplasm9.8CD79A, TGM2
34juvenile dermatitis herpetiformis9.8CD79A, TGM2
35palmoplantar keratosis9.8CD79A, MMP9
36intrinsic cardiomyopathy9.8CD79A, TGM2
37plasmacytoma9.8CHGA, MMP9
38ulcerative colitis9.7
39crohn's colitis9.7
40psoriasis9.7
41gemistocytic astrocytoma9.7ATP4A, CD79A, MMP9
42tularemia9.7CD79A, TGM2
43blood group incompatibility9.7CD79A, TGM2
44satoyoshi syndrome9.6
45autoimmune hepatitis9.6
46hepatitis9.6
47diversion colitis9.6
48cardiac arrest9.6
49interstitial nephritis9.6
50esophagitis9.6

Graphical network of the top 20 diseases related to Lymphocytic Colitis:



Diseases related to lymphocytic colitis

Symptoms for Lymphocytic Colitis

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Drugs & Therapeutics for Lymphocytic Colitis

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Drugs for Lymphocytic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1glucocorticoidsPhase 3, Phase 24756
2
BudesonidePhase 3, Phase 241151333-22-363006, 5281004
Synonyms:
(11-beta,16-alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(11beta,16alpha)-16,17-(Butylidenebis(oxy))-11,21-dihydroxypregna-1,4-diene-3,20-dione
(4aR,4bS,5S,6aS,6bS,8R,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS)-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-8-propyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
(R,S)-11b,16a,17,21,tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with buty raldehyde
(RS)-(11beta,16alpha)-16,17-[Butylidenebis(oxy)]-11,21-dihydroxypregna-1,4-diene-3,20-dione
(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with butyraldehyde
(S)-16alpha,17-(Butylidenedioxy)-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
11beta,21-dihydroxy-16alpha,17alpha-(butane-1,1-diyldioxy)pregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11,21-dihydroxypregna-1,4-diene-3,20-dione
16,17-Butylidenebis(oxy)-11-,21-dihydroxypregna-1,4-diene-3,20-dione
16-alpha,17-alpha-Butylidenedioxy-11-beta,21-dihydroxy-1,4-pregnadiene-3,20-dione
16alpha(R),17-(Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
16alpha-,17alpha--butylidenedioxypregna-1,4-diene-11beta-,21-diol-3,20-dione
51333-22-3
AC-4697
AC1L1DQE
AC1L1Y6Y
AC1L22VC
AC1MHWI7
B 7777
B7777_SIGMA
BPBio1_000523
BRD-A34299591-001-03-4
BRD-A82238138-001-01-7
BSPBio_000475
BSPBio_002160
Bidien
Bio-0010
Budecort Inhaler
Budenofalk
Budeson
Budesonide (JAN/USAN/INN)
Budesonide Easyhaler
Budesonide MMX
Budesonide [USAN:INN:BAN:JAN]
Budesonido
Budesonido [INN-Spanish]
Budesonidum
Budesonidum [INN-Latin]
Budiair
Budicort
C25H34O6
CCRIS 5230
CHEBI:3207
CHEBI:656601
CHEMBL1370
CID2462
CID3033890
CID40000
CID5281004
CID63006
CPD000058337
Cortivent
D00246
DB01222
Desowen
Dexbudesonide
Dexbudesonide [INN]
DivK1c_000475
EINECS 257-139-7
EINECS 257-160-1
EINECS 257-161-7
EU-0100174
Entocort
Entocort EC
Entocort EC (TN)
Giona Easyhaler
HMS1569H17
HMS1921I22
HMS2094I13
HMS501H17
Horacort
 
IDI1_000475
Inflammide
KBio1_000475
KBio3_001660
KBioGR_001361
LS-187734
LS-7235
Lopac0_000174
MAP-0010
MLS000028507
MLS001077323
MLS002207112
Micronyl
Miflonide
MolPort-002-529-265
MolPort-003-666-332
MolPort-003-986-909
NCGC00015165-03
NCGC00021318-03
NCGC00021318-06
NCGC00089747-02
NCGC00089747-03
NCGC00089747-04
NCGC00178789-01
NINDS_000475
Noex
Preferid
Pregna-1,4-diene-3,20-dione, 16,17-butylidenebis(oxy)-11,21-dihydroxy-, (11beta,16alpha(R))-, and 16alpha,17-((S)-Butylidenebis(oxy))-11beta,21-dihydroxypregna-1,4-diene-3,20-dione
Prestwick0_000518
Prestwick1_000518
Prestwick2_000518
Prestwick3_000518
Prestwick_840
Pulmaxan
Pulmaxan turbohaler
Pulmicort
Pulmicort (TN)
Pulmicort Flexhaler
Pulmicort Nebuamp
Pulmicort Respules
Pulmicort Topinasal
Pulmicort Turbuhaler
Pulmicort turbuhaler
Respules
Rhinocort
Rhinocort Aqua
Rhinocort Turbuhaler
Rhinocort alpha
Rhinocort, Pulmicort , Entocort, Symbicort, Noex. Entocort EC, Budesonide
Rhinosol
S 1320
S-1320
S1286_Selleck
SAM002699898
SMR000058337
SPBio_000586
SPBio_002396
SPECTRUM1500813
ST51039033
Spectrum2_000623
Spectrum3_000620
Spectrum4_000821
Spectrum5_001738
Spirocort
TL8003397
Tridesilon
UDB
UNII-168L5HT37P
UNII-2HI1006KPH
UNII-Q3OKS62Q6X
Unit dose budesonide
ZINC03938751
ZINC04097286
budesonide
3MesalaminePhase 315689-57-6
4
Bismuth1197440-69-916682734, 105143
Synonyms:
17034_FLUKA
24267-48-9
25243-76-9
264008_ALDRICH
265462_ALDRICH
265470_ALDRICH
452386_ALDRICH
556130_ALDRICH
7440-69-9
83Bi
95372_ALDRICH
95372_FLUKA
95375_FLUKA
AC1NSDYX
AC1O4PN8
AR-1I0647
BISMUTH, 99.95%
 
BISMUTH, 99.999%
Bi
Bismut
Bismuth standard for AAS
Bismuth standard for ICP
Bismuth(III) nitrate solution
Bismuth, elemental
Bismuth-209
C15471
CHEBI:33301
CID5359367
EINECS 231-177-4
HSDB 2078
LS-44708
LTBB002773
MolPort-003-925-759
Wismut
bismuth
bismuto
5COLANutraceutical1824

Interventional clinical trials:

idNameStatusNCT IDPhase
1Budesonide Treatment for Lymphocytic ColitisCompletedNCT00180050Phase 3
2Budesonide Versus Mesalazine Versus Placebo in Lymphocytic ColitisRecruitingNCT01209208Phase 3
3Budesonide Versus Placebo for the Treatment of Lymphocytic ColitisTerminatedNCT00217022Phase 2, Phase 3
4Case-Control Study to Identify Risk Factors for Microscopic ColitisCompletedNCT01928667
5Usefulness of Chromoendoscopy in Diagnosing Microscopic ColitisRecruitingNCT01504048
6Treatment of Microscopic ColitisTerminatedNCT00184171

Search NIH Clinical Center for Lymphocytic Colitis


Cochrane evidence based reviews: colitis, lymphocytic

Genetic Tests for Lymphocytic Colitis

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Anatomical Context for Lymphocytic Colitis

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MalaCards organs/tissues related to Lymphocytic Colitis:

34
Colon, Endothelial, Monocytes, Small intestine

Animal Models for Lymphocytic Colitis or affiliated genes

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MGI Mouse Phenotypes related to Lymphocytic Colitis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4CD79A, MMP9, PTGER4, TGM2
2MP:00053678.0CD79A, CHGA, MMP9, TGM2
3MP:00053877.4ATP4A, CD79A, IRAK2, MMP9, PTGER4, TGM2
4MP:00053977.2ATP4A, CD79A, IRAK2, MMP9, PTGER4, TGM2
5MP:00053766.4ATP4A, CD79A, CHGA, IRAK2, MMP9, PTGER4

Publications for Lymphocytic Colitis

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Articles related to Lymphocytic Colitis:

(show top 50)    (show all 112)
idTitleAuthorsYear
1
Microscopic colitis: a descriptive clinical cohort study of 795 patients with collagenous and lymphocytic colitis. (26679722)
2016
2
Association of lymphocytic colitis and lactase deficiency in pediatric population. (25523228)
2015
3
Lymphocytic colitis secondary to ipilimumab treatment. (22114048)
2013
4
Macroscopic Findings in Lymphocytic Colitis. (24211291)
2013
5
In vivo diagnosis of lymphocytic colitis by confocal laser endomicroscopy. (22851663)
2013
6
Cryptosporidiosis-associated lymphocytic colitis. (23912411)
2013
7
MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis. (22147390)
2012
8
Duloxetine-induced lymphocytic colitis. (22874808)
2012
9
Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. (22699394)
2012
10
The various faces of autoimmune endocrinopathies: non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis. (23043903)
2012
11
Unique endoscopic findings in lymphocytic colitis. (22305502)
2011
12
High chromogranin A cell density in the colon of patients with lymphocytic colitis. (21584496)
2011
13
Lymphocytic colitis in Satoyoshi syndrome. (20710153)
2010
14
Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. (20809338)
2010
15
Lymphocytic colitis under treatment with duloxetine. (20517807)
2010
16
Lymphocytic colitis presenting as difficult diarrhoea in an African woman: a case report and review of the literature. (20205879)
2010
17
A retrospective study on a cohort of patients with lymphocytic colitis. (20575599)
2010
18
Pitfalls and errors in the diagnosis of collagenous and lymphocytic colitis. (21172236)
2008
19
Oral pH-modified release budesonide for treatment of inflammatory bowel disease, collagenous and lymphocytic colitis. (18422482)
2008
20
Lymphocytic colitis. (17693240)
2007
21
Lymphocytic colitis in a patient with psoriasis responsive to budesonide. (17454870)
2007
22
In vivo histopathology of lymphocytic colitis. (17521648)
2007
23
Interventions for treating lymphocytic colitis. (17253579)
2007
24
Collagenous colitis and lymphocytic colitis: patient characteristics and clinical presentation. (15932175)
2005
25
Sequential clinical and histopathological changes in collagenous and lymphocytic colitis over time. (14976531)
2004
26
Luminal nitric oxide and epithelial expression of inducible and endothelial nitric oxide synthase in collagenous and lymphocytic colitis. (12608467)
2003
27
Collagenous and lymphocytic colitis. evaluation of clinical and histological features, response to treatment, and long-term follow-up. (12591052)
2003
28
Lymphocytic colitis: clinical features, treatment, and outcomes. (12425555)
2002
29
Lymphocytic colitis treated with proctocolectomy and ileal J-pouch-anal anastomosis: report of a case. (11786777)
2002
30
Cryptal lymphocytic coloproctitis: a new phenotype of lymphocytic colitis? (11865010)
2002
31
Role of bile acids in lymphocytic colitis. (11995467)
2002
32
Monocyte chemotactic protein-1 in a randomized placebo controlled study of canine plasmacytic-lymphocytic colitis. (12590872)
2002
33
Collagenous and lymphocytic colitis in Iceland. (12018911)
2002
34
Azathioprine as a treatment of refractory lymphocytic colitis. (11338080)
2001
35
Celiac disease is highly prevalent in lymphocytic colitis. (11246349)
2001
36
Prevalence of celiac disease in collagenous and lymphocytic colitis. (11125181)
2000
37
Acarbose and lymphocytic colitis. (11072952)
2000
38
Incidence of collagenous and lymphocytic colitis: a 5-year population-based study. (10022639)
1999
39
Hyposplenism, antiendomysial antibodies and lymphocytic colitis in collagenous sprue. (10360997)
1999
40
Microscopic colitis syndrome: lymphocytic colitis and collagenous colitis. (10548408)
1999
41
Association of lymphocytic colitis with linear IgA dermatosis. (10427659)
1999
42
Lymphocytic colitis: clinical presentation and long term course. (9824342)
1998
43
Increased nitric oxide production in collagenous and lymphocytic colitis. (9373768)
1997
44
Ranitidine, diarrhoea, and lymphocytic colitis. (8549950)
1995
45
Collagenous and lymphocytic colitis: subject review and therapeutic alternatives. (7661156)
1995
46
Drug induced lymphocytic colitis. (8150360)
1994
47
Collagenous colitis and lymphocytic colitis. (8198370)
1994
48
Lymphocytic colitis. A definable clinical and histological diagnosis. (8508711)
1993
49
Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. (1551336)
1992
50
Newly recognized forms of colitis: collagenous colitis, microscopic (lymphocytic) colitis, and lymphoid follicular proctitis. (1925124)
1991

Variations for Lymphocytic Colitis

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Expression for genes affiliated with Lymphocytic Colitis

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Search GEO for disease gene expression data for Lymphocytic Colitis.

Pathways for genes affiliated with Lymphocytic Colitis

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Pathways related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6MMP9, PTGER4

GO Terms for genes affiliated with Lymphocytic Colitis

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Biological processes related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1JNK cascadeGO:00072549.4IRAK2, PTGER4
2positive regulation of cell adhesionGO:00457859.2PTGER4, TGM2
3positive regulation of inflammatory responseGO:00507299.1PTGER4, TGM2

Sources for Lymphocytic Colitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet