MCID: LYM042
MIFTS: 35

Lymphocytic Colitis

Categories: Rare diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Colitis

MalaCards integrated aliases for Lymphocytic Colitis:

Name: Lymphocytic Colitis 12 50 14
Colitis, Lymphocytic 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0060184
ICD10 33 K52.89
MeSH 42 D046730
NCIt 47 C27147
SNOMED-CT 64 31437008
UMLS 69 C0400822

Summaries for Lymphocytic Colitis

NIH Rare Diseases : 50 lymphocytic colitis is form of microscopic colitis, a condition that is characterized by inflammation of the colon (large intestines). as the name suggests, microscopic colitis can only be diagnosed by examining a small sample of colon tissue under a microscope. in lymphocytic colitis, specifically, the tissues and lining of the colon are of normal thickness, but an increase in the number of lymphocytes (a type of white blood cell) is observed. signs and symptoms of the condition may include chronic, watery diarrhea; abdominal pain, cramping, and bloating; weight loss; nausea; dehydration; and/or fecal incontinence. the underlying cause of lymphocytic colitis is currently unknown; however, scientists suspect that autoimmune conditions, medications, infections, genetic factors, and/or bile acid malabsorption may contribute to the development of the condition. treatment is based on the signs and symptoms present in each person and may include certain medications, dietary modifications, and in rare cases, surgery. last updated: 4/6/2016

MalaCards based summary : Lymphocytic Colitis, also known as colitis, lymphocytic, is related to collagenous colitis and microscopic colitis. An important gene associated with Lymphocytic Colitis is CHGA (Chromogranin A), and among its related pathways/superpathways is Celecoxib Pathway, Pharmacodynamics. The drugs Budesonide and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include colon, endothelial and monocytes, and related phenotypes are homeostasis/metabolism and hematopoietic system

Disease Ontology : 12 A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria).

Wikipedia : 72 Lymphocytic colitis is a subtype of microscopic colitis, a condition characterized by chronic non-bloody... more...

Related Diseases for Lymphocytic Colitis

Diseases related to Lymphocytic Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 collagenous colitis 11.2
2 microscopic colitis 11.2
3 basophilic carcinoma 10.5 CHGA PTGER4
4 colitis 10.5
5 childhood choriocarcinoma of the ovary 10.5 CHGA MMP9
6 primary syphilis 10.5 ATP4A CHGA
7 bone giant cell sarcoma 10.5 ATP4A CHGA
8 carcinoma of unknown primary site, childhood 10.5 CHGA PYY
9 acquired aneurysmal subarachnoid hemorrhage 10.4 CHGA PYY
10 mesenteric vascular occlusion 10.4 ATP4A PYY
11 familial short qt syndrome 10.3 MMP9 TGM2
12 amyotrophic lateral sclerosis type 5 10.3 ATP4A TGM2
13 toxic optic neuropathy 10.2 CD79A MMP9
14 clostridium difficile colitis 10.2 CD79A CHGA
15 necrobiosis lipoidica 10.2 CD79A MMP9
16 sialadenitis 10.2 CD79A MMP9
17 atheroembolism of kidney 10.1 ATP4A CD79A
18 substance-induced psychosis 10.1 ATP4A CD79A
19 follicular mucinosis 10.1 CD79A MMP9
20 brown-vialetto-van laere syndrome 10.1 CHGA MMP9
21 cutaneous t cell lymphoma 10.1 CD79A TGM2
22 ileocolitis 10.1 ATP4A CD79A
23 myositis fibrosa 10.1 CHGA PYY TGM2
24 diffuse cutaneous mastocytosis 10.1 CD79A TGM2
25 b cell linker protein deficiency 10.0 CD79A TGM2
26 autism spectrum disorder 10.0 CD79A TGM2
27 anaerobic meningitis 10.0 CD79A TGM2
28 specific developmental disorder 10.0 CD79A TGM2
29 germ cell and embryonal cancer 9.9 CD79A MMP9
30 subcorneal pustular dermatosis 9.9 CD79A TGM2
31 fibrosarcomatous osteosarcoma 9.9 ATP4A CD79A
32 celiac disease 9.9
33 brain germinoma 9.9 CD79A TGM2
34 lymphoma, malt, somatic 9.8 ATP4A CD79A
35 tuberculum sellae meningioma 9.8 ATP4A CD79A PYY
36 acute chest syndrome 9.7 CD79A MMP9
37 diarrhea 9.7
38 gastritis 9.7
39 lymphoma 9.7 CD79A TGM2
40 solitary bone cyst 9.7 ALDOB CD79A
41 crohn's colitis 9.6
42 ulcerative colitis 9.6
43 inflammatory bowel disease 9.6
44 psoriasis 9.6
45 cardiac arrest 9.5
46 interstitial nephritis 9.5
47 esophagitis 9.5
48 cryptosporidiosis 9.5
49 food allergy 9.5
50 satoyoshi syndrome 9.5

Graphical network of the top 20 diseases related to Lymphocytic Colitis:



Diseases related to Lymphocytic Colitis

Symptoms & Phenotypes for Lymphocytic Colitis

MGI Mouse Phenotypes related to Lymphocytic Colitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.86 ATP4A CD79A CHGA IRAK2 MMP9 PTGER4
2 hematopoietic system MP:0005397 9.8 ATP4A CD79A IRAK2 MMP9 PTGER4 TGM2
3 immune system MP:0005387 9.7 ALDOB ATP4A CD79A IRAK2 MMP9 PTGER4
4 mortality/aging MP:0010768 9.5 ALDOB ATP4A CHGA IRAK2 MMP9 PTGER4
5 neoplasm MP:0002006 8.92 PTGER4 TGM2 CD79A MMP9

Drugs & Therapeutics for Lymphocytic Colitis

Drugs for Lymphocytic Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Budesonide Approved Phase 3,Phase 2 51333-22-3 63006 5281004
2 Analgesics Phase 3
3 Analgesics, Non-Narcotic Phase 3
4 Anti-Asthmatic Agents Phase 3,Phase 2
5 Anti-Inflammatory Agents Phase 3,Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 3
7 Antirheumatic Agents Phase 3
8 Autonomic Agents Phase 3,Phase 2
9 Bronchodilator Agents Phase 3,Phase 2
10 glucocorticoids Phase 3,Phase 2
11 Hormone Antagonists Phase 3,Phase 2
12 Hormones Phase 3,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
14 Mesalamine Phase 3 89-57-6
15 Peripheral Nervous System Agents Phase 3,Phase 2
16 Respiratory System Agents Phase 3,Phase 2
17
Idelalisib Approved 870281-82-6
18 Pharmaceutical Solutions
19 Antacids
20 Anti-Ulcer Agents
21
Bismuth 7440-69-9 16682734 105143
22 Gastrointestinal Agents
23 Cola Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Budesonide Versus Mesalazine Versus Placebo in Lymphocytic Colitis Completed NCT01209208 Phase 3 Budesonide;Mesalamine
2 Budesonide Treatment for Lymphocytic Colitis Completed NCT00180050 Phase 3 Budesonide
3 Budesonide Versus Placebo for the Treatment of Lymphocytic Colitis Terminated NCT00217022 Phase 2, Phase 3 Budesonide
4 Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis Unknown status NCT01504048
5 Case-Control Study to Identify Risk Factors for Microscopic Colitis Completed NCT01928667
6 Mechanisms of Idelalisib-Associated Diarrhea in Patients With Relapsed Chronic Lymphocytic Leukemia, Indolent Non-hodgkin Lymphoma, or Small Lymphocytic Lymphoma Recruiting NCT02928510 Idelalisib
7 Treatment of Microscopic Colitis Terminated NCT00184171 Budesonide;Bismuth;Fiber

Search NIH Clinical Center for Lymphocytic Colitis

Cochrane evidence based reviews: colitis, lymphocytic

Genetic Tests for Lymphocytic Colitis

Anatomical Context for Lymphocytic Colitis

MalaCards organs/tissues related to Lymphocytic Colitis:

39
Colon, Endothelial, Monocytes, Small Intestine

Publications for Lymphocytic Colitis

Articles related to Lymphocytic Colitis:

(show top 50) (show all 114)
id Title Authors Year
1
Epithelial barrier dysfunction in lymphocytic colitis through cytokine-dependent internalization of claudin-5 and -8. ( 28138755 )
2017
2
Interventions for treating lymphocytic colitis. ( 28702956 )
2017
3
Bullous Pemphigoid with Lymphocytic Colitis: A Case Report and Short Literature Review. ( 27469343 )
2016
4
ENaC Dysregulation Through Activation of MEK1/2 Contributes to Impaired Na+ Absorption in Lymphocytic Colitis. ( 26658215 )
2016
5
Microscopic colitis: a descriptive clinical cohort study of 795 patients with collagenous and lymphocytic colitis. ( 26679722 )
2016
6
HLA Associations Distinguish Collagenous From Lymphocytic Colitis. ( 27481432 )
2016
7
CD3 immunohistochemical staining in diagnosis of lymphocytic colitis. ( 26772395 )
2016
8
Cat Scratch Colon in a Patient With Lymphocytic Colitis. ( 27580771 )
2016
9
Association of lymphocytic colitis and lactase deficiency in pediatric population. ( 25523228 )
2015
10
Clinical characteristics and patterns and predictors of response to therapy in collagenous and lymphocytic colitis. ( 25997458 )
2015
11
Increased Production of Lysozyme Associated with Bacterial Proliferation in Barrett's Esophagitis, Chronic Gastritis, Gluten-induced Atrophic Duodenitis (Celiac Disease), Lymphocytic Colitis, Collagenous Colitis, Ulcerative Colitis and Crohn's Colitis. ( 26637845 )
2015
12
Lymphocytic colitis complicated by a mass in the terminal ileum. ( 26034326 )
2015
13
Does Lymphocytic Colitis Always Present with Normal Endoscopic Findings? ( 25167800 )
2014
14
Lymphocytic colitis secondary to ipilimumab treatment. ( 22114048 )
2013
15
In vivo diagnosis of lymphocytic colitis by confocal laser endomicroscopy. ( 22851663 )
2013
16
Stable incidence of collagenous colitis and lymphocytic colitis in A9rebro, Sweden, 1999-2008: a continuous epidemiologic study. ( 23945183 )
2013
17
Cryptosporidiosis-associated lymphocytic colitis. ( 23912411 )
2013
18
Lymphocytic colitis is associated with increased pro-inflammatory cytokine profile and up regulation of prostaglandin receptor EP4. ( 23613969 )
2013
19
Clinical presentation, diagnosis, pathogenesis and treatment options for lymphocytic colitis (Review). ( 23695201 )
2013
20
Macroscopic Findings in Lymphocytic Colitis. ( 24211291 )
2013
21
Systematic review: are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis? ( 22670660 )
2012
22
Duloxetine-induced lymphocytic colitis. ( 22874808 )
2012
23
High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. ( 23155335 )
2012
24
The various faces of autoimmune endocrinopathies: non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis. ( 23043903 )
2012
25
Cardiac arrest due to lymphocytic colitis: a case report. ( 22405093 )
2012
26
Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. ( 22699394 )
2012
27
MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis. ( 22147390 )
2012
28
Lymphocytic colitis and collagenous colitis: a review of clinicopathologic features and immunologic abnormalities. ( 22156832 )
2012
29
Letter: are lymphocytic colitis and collagenous colitis really the same disease? ( 22913854 )
2012
30
The behavior of matrix metalloproteinase-9 in lymphocytic colitis, collagenous colitis and ulcerative colitis. ( 21678108 )
2012
31
Are collagenous and lymphocytic colitis different aspects of the same disease? ( 23016916 )
2012
32
High chromogranin A cell density in the colon of patients with lymphocytic colitis. ( 21584496 )
2011
33
Unique endoscopic findings in lymphocytic colitis. ( 22305502 )
2011
34
Evolution of the incidence of collagenous colitis and lymphocytic colitis in Terrassa, Spain: a population-based study. ( 20878755 )
2011
35
Pediatric lymphocytic colitis presenting with intractable diarrhea. ( 21543998 )
2011
36
A retrospective study on a cohort of patients with lymphocytic colitis. ( 20575599 )
2010
37
Lymphocytic colitis under treatment with duloxetine. ( 20517807 )
2010
38
Lymphocytic colitis presenting as difficult diarrhoea in an African woman: a case report and review of the literature. ( 20205879 )
2010
39
Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. ( 20809338 )
2010
40
Lymphocytic colitis in Satoyoshi syndrome. ( 20710153 )
2010
41
Nodular lymphoid hyperplasia and histologic changes mimicking celiac disease, collagenous sprue, and lymphocytic colitis in a patient with selective IgA deficiency. ( 19286327 )
2009
42
Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study. ( 19303012 )
2009
43
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study. ( 19352342 )
2009
44
Large intestine: Remission of lymphocytic colitis with budesonide. ( 19713982 )
2009
45
Collagenous and lymphocytic colitis: systematic review and update of the literature. ( 20203510 )
2009
46
Enterocolic lymphocytic phlebitis and lymphocytic colitis: drug-related coexistent pathology. ( 18758788 )
2009
47
Interventions for treating lymphocytic colitis. ( 18425936 )
2008
48
Lymphocytic colitis in a child with non-responsive celiac disease. ( 19317281 )
2008
49
Pitfalls and errors in the diagnosis of collagenous and lymphocytic colitis. ( 21172236 )
2008
50
Oral pH-modified release budesonide for treatment of inflammatory bowel disease, collagenous and lymphocytic colitis. ( 18422482 )
2008

Variations for Lymphocytic Colitis

Expression for Lymphocytic Colitis

Search GEO for disease gene expression data for Lymphocytic Colitis.

Pathways for Lymphocytic Colitis

Pathways related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.39 MMP9 PTGER4

GO Terms for Lymphocytic Colitis

Biological processes related to Lymphocytic Colitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 8.96 PTGER4 TGM2
2 JNK cascade GO:0007254 8.62 IRAK2 PTGER4

Sources for Lymphocytic Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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