MCID: LYM042
MIFTS: 43

Lymphocytic Colitis malady

Gastrointestinal diseases, Rare diseases, Immune diseases categories
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Summaries for Lymphocytic Colitis

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Disease Ontology:8 A colitis characterized by an accumulation of lymphocytes in the colonic epithelium and connective tissue (lamina propria).

MalaCards based summary: Lymphocytic Colitis, also known as colitis, lymphocytic, is related to collagenous colitis and celiac disease. An important gene associated with Lymphocytic Colitis is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Spinal Cord Injury and AGE/RAGE pathway. The compounds oxyntomodulin and fluoride have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and monocytes, and related mouse phenotypes are renal/urinary system and tumorigenesis.

Wikipedia:65 Lymphocytic colitis, a subtype of microscopic colitis, is a rare condition characterized by chronic... more...

Aliases & Classifications for Lymphocytic Colitis

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Sources:
8Disease Ontology, 48Orphanet, 62UMLS, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Lymphocytic Colitis, Aliases & Descriptions:

Name: Lymphocytic Colitis 8 48
 
Colitis, Lymphocytic 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:0060184
MeSH34 D046730
MESH via Orphanet35 D046730
ICD10 via Orphanet26 K52.8
UMLS via Orphanet63 C0400822

Related Diseases for Lymphocytic Colitis

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Diseases related to Lymphocytic Colitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1collagenous colitis31.5NOS2
2celiac disease30.8PYY, CD79A
3diarrhea30.4CD79A, CHGA, PYY
4gastritis30.2CHGA, NOS2, CD79A
5colitis11.0
6serotonin syndrome10.2PYY, CHGA
7hypertension10.2CD79A, MMP9
8interstitial lung disease10.2MMP9, CD79A
9glucose intolerance10.2PYY, CD79A
10meningitis10.2MMP9, CD79A
11neuroendocrine tumor10.2CHGA, PYY
12microscopic colitis10.2
13psoriasis10.2
14inflammatory bowel disease10.2
15mucoepidermoid carcinoma10.2NOS2, CHGA
16focal segmental glomerulosclerosis10.2NOS2, CD79A
17peripheral primitive neuroectodermal tumor10.1PYY, CHGA
18periodontal disease10.1CD79A, MMP9
19carcinoid syndrome10.1PYY, CHGA
20glomerulosclerosis10.1CD79A, NOS2
21congenital heart disease10.0MMP9, CD79A
22cholera10.0CD79A, PYY
23autoimmune hepatitis10.0
24hepatitis10.0
25ulcerative colitis10.0
26cryptosporidiosis10.0
27crohn's colitis10.0
28diversion colitis10.0
29appendicitis10.0
30proctitis10.0
31food allergy10.0
32interstitial nephritis10.0
33collagenous gastritis10.0
34linear iga disease10.0
35satoyoshi syndrome10.0
36nephritis10.0
37blindness10.0
38endotheliitis10.0
39pancreatic cancer10.0CHGA, MMP9, PYY
40diabetes mellitus10.0CD79A, MMP9, PYY
41glomerulonephritis10.0CD79A, NOS2
42transitional cell carcinoma9.9MMP9, PTGER4
43breast cancer9.9MMP9, CHGA, NOS2
44lung cancer9.9CHGA, MMP9, PTGER4
45rheumatoid arthritis9.8CD79A, NOS2, MMP9
46adenoma9.8CHGA, PTGER4, PYY
47tongue squamous cell carcinoma9.8NOS2, CHGA, MMP9
48non-small cell lung carcinoma9.8PTGER4, CHGA
49asthma9.6CD79A, NOS2, MMP9, PTGER4
50colonic benign neoplasm9.5PYY, PTGER4, MMP9, NOS2

Graphical network of the top 20 diseases related to Lymphocytic Colitis:



Diseases related to lymphocytic colitis

Symptoms for Lymphocytic Colitis

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Drugs & Therapeutics for Lymphocytic Colitis

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Drug clinical trials:

Search ClinicalTrials for Lymphocytic Colitis

Search NIH Clinical Center for Lymphocytic Colitis

Genetic Tests for Lymphocytic Colitis

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Anatomical Context for Lymphocytic Colitis

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MalaCards organs/tissues related to Lymphocytic Colitis:

32
Colon, Small intestine, Monocytes, Endothelial

Animal Models for Lymphocytic Colitis or affiliated genes

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MGI Mouse Phenotypes related to Lymphocytic Colitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.6MMP9, CHGA, NOS2, CD79A
2MP:00020068.4NOS2, MMP9, PTGER4
3MP:00053858.1PTGER4, MMP9, CHGA, NOS2
4MP:00053908.1NOS2, MMP9, PTGER4, PYY
5MP:00053868.0NOS2, MMP9, PTGER4, PYY
6MP:00053977.8PTGER4, MMP9, NOS2, CD79A
7MP:00053767.3CD79A, NOS2, CHGA, MMP9, PTGER4, PYY

Publications for Lymphocytic Colitis

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Articles related to Lymphocytic Colitis:

(show top 50)    (show all 101)
idTitleAuthorsYear
1
Clinical presentation, diagnosis, pathogenesis and treatment options for lymphocytic colitis (Review). (23695201)
2013
2
Lymphocytic colitis secondary to ipilimumab treatment. (22114048)
2013
3
Macroscopic Findings in Lymphocytic Colitis. (24211291)
2013
4
Letter: are lymphocytic colitis and collagenous colitis really the same disease? (22913854)
2012
5
Cardiac arrest due to lymphocytic colitis: a case report. (22405093)
2012
6
MPA: a treatment option for lymphocytic colitis and mesalamine-induced interstitial nephritis. (22147390)
2012
7
Duloxetine-induced lymphocytic colitis. (22874808)
2012
8
Chromogranin A cell density as a diagnostic marker for lymphocytic colitis. (22699394)
2012
9
High densities of serotonin and peptide YY cells in the colon of patients with lymphocytic colitis. (23155335)
2012
10
Pediatric lymphocytic colitis presenting with intractable diarrhea. (21543998)
2011
11
Unique endoscopic findings in lymphocytic colitis. (22305502)
2011
12
Evolution of the incidence of collagenous colitis and lymphocytic colitis in Terrassa, Spain: a population-based study. (20878755)
2011
13
Lymphocytic colitis in Satoyoshi syndrome. (20710153)
2010
14
Differences in the T-bet and GATA-3 expression patterns between lymphocytic colitis and coeliac disease. (20809338)
2010
15
Lymphocytic colitis under treatment with duloxetine. (20517807)
2010
16
Lymphocytic colitis presenting as difficult diarrhoea in an African woman: a case report and review of the literature. (20205879)
2010
17
Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study. (19352342)
2009
18
Collagenous and lymphocytic colitis: systematic review and update of the literature. (20203510)
2009
19
Budesonide is effective in treating lymphocytic colitis: a randomized double-blind placebo-controlled study. (19303012)
2009
20
Large intestine: Remission of lymphocytic colitis with budesonide. (19713982)
2009
21
Pitfalls and errors in the diagnosis of collagenous and lymphocytic colitis. (21172236)
2008
22
Interventions for treating lymphocytic colitis. (18425936)
2008
23
Lymphocytic colitis. (17693240)
2007
24
Lymphocytic colitis: a clue to bacterial etiology. (16437626)
2005
25
Seasonal pattern of onset in lymphocytic colitis. (16208113)
2005
26
Lymphocytic colitis: a retrospective clinical study of 199 Swedish patients. (15016748)
2004
27
Luminal nitric oxide and epithelial expression of inducible and endothelial nitric oxide synthase in collagenous and lymphocytic colitis. (12608467)
2003
28
Lymphocytic colitis: clinical features, treatment, and outcomes. (12425555)
2002
29
Lymphocytic colitis treated with proctocolectomy and ileal J-pouch-anal anastomosis: report of a case. (11786777)
2002
30
Cryptal lymphocytic coloproctitis: a new phenotype of lymphocytic colitis? (11865010)
2002
31
Azathioprine as a treatment of refractory lymphocytic colitis. (11338080)
2001
32
Familial occurrence of lymphocytic colitis. (11727006)
2001
33
Cryptal lymphocytic colitis: a new entity in baboons. (10945162)
2000
34
Prevalence of celiac disease in collagenous and lymphocytic colitis. (11125181)
2000
35
Colonic epithelial lymphocytosis and lymphocytic colitis: descriptive histopathology versus distinct clinicopathologic entities. (10907806)
2000
36
Lymphocytic colitis: a clue to an infectious trigger. (10048742)
1999
37
Lymphocytic colitis, induced by ticlopidine. (10604225)
1999
38
Incidence of collagenous and lymphocytic colitis: a 5-year population-based study. (10022639)
1999
39
Hyposplenism, antiendomysial antibodies and lymphocytic colitis in collagenous sprue. (10360997)
1999
40
Lymphocytic colitis: a distinct clinical entity? A clinicopathological confrontation of lymphocytic and collagenous colitis. (10446105)
1999
41
Linear IgA disease associated with lymphocytic colitis. (10233230)
1999
42
Lymphocytic colitis: clinical presentation and long term course. (9824342)
1998
43
Failure of added dietary gluten to induce small intestinal histopathological changes in patients with watery diarrhea and lymphocytic colitis. (9113884)
1996
44
Collagenous gastritis associated with lymphocytic colitis. (8742654)
1996
45
Immunohistological study of IgA, IgG and IgM in endoscopic biopsies of dogs with plasmacytic-lymphocytic colitis. (9011157)
1996
46
Are collagenous colitis and lymphocytic colitis distinct syndromes? (8542665)
1995
47
Ranitidine, diarrhoea, and lymphocytic colitis. (8549950)
1995
48
Collagenous, microscopic and lymphocytic colitis. An evolving concept. (8055150)
1994
49
Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. (1551336)
1992
50
Plasmacytic lymphocytic colitis in the dog. (2629052)
1989

Variations for Lymphocytic Colitis

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Expression for genes affiliated with Lymphocytic Colitis

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Expression patterns in normal tissues for genes affiliated with Lymphocytic Colitis

Search GEO for disease gene expression data for Lymphocytic Colitis.

Pathways for genes affiliated with Lymphocytic Colitis

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Pathways related to Lymphocytic Colitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3NOS2, MMP9
29.3NOS2, MMP9
39.1MMP9, PTGER4
49.1MMP9, PTGER4

Compounds for genes affiliated with Lymphocytic Colitis

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Compounds related to Lymphocytic Colitis according to GeneCards/GeneDecks:

(show top 50)    (show all 67)
idCompoundScoreTop Affiliating Genes
1oxyntomodulin44 6110.9CHGA, PYY
2fluoride449.9CHGA, CD79A
3anti-fungal449.9CD79A, CHGA
4omeprazole44 50 28 24 1113.9PYY, CHGA
5clonidine44 50 28 1112.8CHGA, PYY
6isoniazid44 50 1111.8CD79A, NOS2
7ivig449.8MMP9, CD79A
8octreotide44 61 28 1112.7PYY, CHGA
9minocycline44 1110.7NOS2, MMP9
10ciglitazone44 2810.7NOS2, MMP9
11parthenolide44 210.7NOS2, MMP9
12doxycycline44 1110.7MMP9, CD79A
13silymarin449.7MMP9, NOS2
14alpha lipoic acid449.7MMP9, NOS2
15hematoxylin449.7MMP9, CHGA
16misoprostol44 1110.7CHGA, PTGER4
17l-nmma449.6MMP9, NOS2
18c-peptide449.6PYY, CHGA
19propranolol44 28 50 24 1113.5CHGA, PYY
20carbachol44 28 1111.5CD79A, CHGA, PYY
21inositol449.5MMP9, CHGA, CD79A
22theophylline44 28 24 1112.5CD79A, CHGA
23formaldehyde44 2410.5CD79A, CHGA, MMP9
24epinephrine44 24 1111.5MMP9, CHGA, CD79A
25fluvastatin44 50 28 1112.5NOS2, MMP9
26fibrinogen449.5CD79A, CHGA, MMP9
27histamine44 28 2411.4PYY, CHGA, CD79A
28gaba449.4PYY, MMP9, CHGA
29lactate449.4CD79A, CHGA, MMP9
30creatinine449.4CD79A, CHGA, MMP9
31isoproterenol44 1110.3NOS2, CHGA, PYY
32n acetylcysteine449.3CD79A, NOS2, MMP9
33cycloheximide449.1NOS2, CHGA, MMP9
34celecoxib44 61 28 50 24 1114.0NOS2, MMP9
35norepinephrine44 24 1111.0CD79A, CHGA, MMP9, PYY
36dopamine44 28 24 1112.0PYY, MMP9, CHGA, CD79A
37cyclic amp44 2410.0CHGA, PTGER4, PYY
38indomethacin44 28 61 1112.0PTGER4, NOS2, CD79A
39ns 39844 6110.0PTGER4, MMP9, NOS2
40acetylcholine44 50 28 24 1112.9PYY, CHGA, NOS2, CD79A
41arginine448.9PYY, CHGA, NOS2, CD79A
42glutamate448.9CD79A, NOS2, CHGA, MMP9
43paraffin448.7PTGER4, MMP9, CHGA, CD79A
44adenylate448.5PTGER4, MMP9, CHGA, NOS2
45pge2448.5CD79A, NOS2, MMP9, PTGER4
46tyrosine448.2PYY, PTGER4, MMP9, CHGA
47dexamethasone44 50 28 1111.1PTGER4, MMP9, CHGA, NOS2, CD79A
48vegf448.1CD79A, NOS2, CHGA, MMP9, PTGER4
49calcium44 50 24 1111.0NOS2, CHGA, MMP9, PTGER4, PYY
50estrogen447.6CD79A, NOS2, CHGA, MMP9, PTGER4, PYY

GO Terms for genes affiliated with Lymphocytic Colitis

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Products for genes affiliated with Lymphocytic Colitis

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Sources for Lymphocytic Colitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet