MCID: LYM015
MIFTS: 33

Lymphocytic Gastritis

Categories: Immune diseases, Gastrointestinal diseases

Aliases & Classifications for Lymphocytic Gastritis

MalaCards integrated aliases for Lymphocytic Gastritis:

Name: Lymphocytic Gastritis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4035
NCIt 46 C27051
SNOMED-CT 64 235658000 360375007
UMLS 69 C1283271

Summaries for Lymphocytic Gastritis

MalaCards based summary : Lymphocytic Gastritis is related to gastritis and orbit lymphoma. An important gene associated with Lymphocytic Gastritis is GZMB (Granzyme B), and among its related pathways/superpathways are Allograft rejection and Apoptosis Modulation and Signaling. The drugs Esomeprazole and Antacids have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Lymphocytic Gastritis

Diseases related to Lymphocytic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 gastritis 10.6
2 orbit lymphoma 10.2 GZMB TIA1
3 lichen sclerosus et atrophicus 10.2 GZMB TIA1
4 lymphomatoid granulomatosis 10.2 GZMB TIA1
5 subcutaneous panniculitis-like t-cell lymphoma 10.2 GZMB TIA1
6 primary cutaneous anaplastic large cell lymphoma 10.2 GZMB TIA1
7 composite lymphoma 10.2 GZMB TIA1
8 hepatosplenic t-cell lymphoma 10.1 GZMB TIA1
9 giardiasis 10.1 GZMB TIA1
10 peripheral t-cell lymphoma 10.1 GZMB TIA1
11 infiltrating lipoma 10.1 GZMB TIA1
12 necrotizing sialometaplasia 10.1 GZMB TIA1
13 reticulosarcoma 10.1 GZMB TIA1
14 celiac disease 1 10.1
15 helicobacter pylori infection 10.1
16 lymphoma, hodgkin, classic 10.0 GZMB TIA1
17 lymphoma 10.0
18 cutaneous t cell lymphoma 10.0 GZMB TIA1
19 breast medullary carcinoma 9.9 FASLG GZMB
20 t-cell large granular lymphocyte leukemia 9.9 FASLG GZMB
21 mycosis fungoides 9.9 GZMB TIA1
22 gastric lymphoma 9.9
23 adenocarcinoma 9.9
24 erythema multiforme 9.9 FASLG GZMB
25 sialolithiasis 9.9 FASLG GZMB
26 acute graft versus host disease 9.9 FASLG GZMB
27 chronic nk-cell lymphocytosis 9.8 B3GAT1 FASLG
28 alopecia areata 9.8 FASLG GZMB
29 type ii mixed cryoglobulinemia 9.8 FAS FASLG
30 gastric cancer 9.8
31 gastric adenocarcinoma 9.8
32 viral esophagitis 9.8 B3GAT1 GZMB TIA1
33 cartilage-hair hypoplasia 9.8 FAS FASLG
34 natural killer cell leukemia 9.8 B3GAT1 GZMB TIA1
35 acute myocarditis 9.8 FAS FASLG
36 central nervous system tuberculosis 9.8 FAS FASLG
37 epstein-barr virus-associated gastric carcinoma 9.8 FAS FASLG
38 brain glioma 9.7 FAS FASLG
39 silicosis 9.7 FAS FASLG
40 panniculitis 9.7 FAS GZMB TIA1
41 pneumoconiosis 9.7 FAS FASLG
42 hemophagocytic lymphohistiocytosis 9.7 FAS GZMB
43 lymphopenia 9.7 FAS FASLG
44 viral hepatitis 9.7 FAS FASLG
45 lymphoma, mucosa-associated lymphoid type 9.7
46 hydrops, lactic acidosis, and sideroblastic anemia 9.7
47 deficiency anemia 9.7
48 vitamin b12 deficiency 9.7
49 mucositis 9.7
50 microinvasive gastric cancer 9.7

Graphical network of the top 20 diseases related to Lymphocytic Gastritis:



Diseases related to Lymphocytic Gastritis

Symptoms & Phenotypes for Lymphocytic Gastritis

GenomeRNAi Phenotypes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

Drugs & Therapeutics for Lymphocytic Gastritis

Drugs for Lymphocytic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 9579578 4594
2 Antacids Phase 3
3 Anti-Ulcer Agents Phase 3
4 Gastrointestinal Agents Phase 3
5 Proton pump inhibitors Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Esomeprazole Treatment for Patients With Lymphocytic Gastritis Unknown status NCT00455754 Phase 3 Esomeprazole

Search NIH Clinical Center for Lymphocytic Gastritis

Genetic Tests for Lymphocytic Gastritis

Anatomical Context for Lymphocytic Gastritis

MalaCards organs/tissues related to Lymphocytic Gastritis:

38
T Cells

Publications for Lymphocytic Gastritis

Articles related to Lymphocytic Gastritis:

(show top 50) (show all 76)
# Title Authors Year
1
Recurrent anaemia in a patient with lymphocytic gastritis and vitamin B12 deficiency. ( 28943131 )
2017
2
Development of lymphocytic gastritis with recurrent Helicobacter pylori infection. ( 28211221 )
2017
3
Lymphocytic Gastritis Identified by Abnormal PET Scan. ( 28462239 )
2017
4
Lymphocytic gastritis: clinical, endoscopic and histopathologic features. ( 27532536 )
2016
5
Propionibacterium acnes overabundance and NKG2D system activation in corpus-dominant lymphocytic gastritis. ( 27538697 )
2016
6
Letter: lymphocytic gastritis and coeliac disease. ( 26331558 )
2015
7
Letter: lymphocytic gastritis and coeliac disease - authors' reply. ( 26331559 )
2015
8
Lymphocytic gastritis showing concomitant occurrence of both CD4 + and CD8 + T-cells among epithelial cells. ( 25047508 )
2014
9
Lymphocytic gastritis is not associated with active Helicobacter pylori infection. ( 24826984 )
2014
10
Helicobacter pylori Associated Lymphocytic Gastritis in a Child. ( 25349835 )
2014
11
Pathology in practice. Severe gastric submucosal edema, with vasculitis, fibrinoid degeneration, and mild eosinophilic and lymphocytic gastritis. ( 24649989 )
2014
12
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. ( 23528908 )
2013
13
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis. ( 23716104 )
2013
14
High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis. ( 23356909 )
2013
15
Lymphocytic gastritis in pediatric celiac disease. ( 21244234 )
2011
16
Endoscopic portrayal of lymphocytic gastritis in a child. ( 20639772 )
2010
17
The frequency of lymphocytic gastritis in baboons. ( 18396790 )
2008
18
Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation. ( 18979579 )
2008
19
The immunohistochemistry profile of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and inflammation. ( 18274643 )
2007
20
Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy--a randomized, double-blind, placebo-controlled multicentre trial. ( 16441467 )
2006
21
Lymphocytic gastritis in Helicobacter pylori-positive gastric MALT lymphoma--report of two cases. ( 15908769 )
2005
22
Resolution of gastrointestinal protein loss after Helicobacter pylori eradication in a patient with hypertrophic lymphocytic gastritis. ( 15610076 )
2004
23
Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence. ( 15509690 )
2004
24
Lymphocytic gastritis in pediatric celiac disease -- immunohistochemical study of the intraepithelial lymphocytic component. ( 14704635 )
2004
25
Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: effect of H pylori treatment. ( 14669318 )
2003
26
Treatment of Helicobacter pylori in patients with lymphocytic gastritis. ( 11490827 )
2001
27
Collagenous gastritis associated with lymphocytic gastritis and celiac disease. ( 11735694 )
2001
28
Clinical and endoscopic improvement of lymphocytic gastritis with eradication of Helicobacter pylori. ( 11474405 )
2001
29
Healing of lymphocytic gastritis by eradication of Helicobacter pylori. ( 11173895 )
2001
30
Lymphocytic gastritis and protein-losing gastropathy. ( 11030189 )
2000
31
Lymphocytic gastritis and Helicobacter pylori: reluctant mucosal partners? ( 11179991 )
2000
32
Effects of Helicobacter pylori eradication on the natural history of lymphocytic gastritis. ( 10486354 )
1999
33
Lymphocytic gastritis: association with etiology and topology. ( 9989841 )
1999
34
The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology. ( 10690170 )
1999
35
Lymphocytic gastritis, Helicobacter pylori, and gastric cancer: is vitamin C the common link? ( 10355855 )
1999
36
Lymphocytic gastritis and Helicobacter pylori: a Brazilian survey. ( 9577382 )
1998
37
Lymphocytic gastritis resembling graft-vs.-host disease following autologous hematopoietic cell transplantation. ( 9701391 )
1998
38
Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia. ( 9932632 )
1998
39
Lymphocytic gastritis: a study of its frequency and review of the literature. ( 9711310 )
1998
40
Lymphocytic gastritis and coeliac disease: evidence of a positive association. ( 9659261 )
1998
41
High proportion of granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis. ( 9537473 )
1998
42
Hypertrophic lymphocytic gastritis with a gastric carcinoma. ( 9831277 )
1998
43
Adenocarcinoma of the small bowel, coeliac disease, and lymphocytic gastritis. ( 10193339 )
1998
44
Successful treatment of protein-losing lymphocytic gastritis with omeprazole. ( 9451692 )
1997
45
Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue. ( 9412920 )
1997
46
Diagnostic criteria in lymphocytic gastritis. ( 9098036 )
1997
47
Lymphocytic gastritis and coeliac disease. ( 8707101 )
1996
48
Lymphocytic gastritis and gastric permeability in patients with celiac disease. ( 8698227 )
1996
49
Association of Helicobacter pylori infection, lymphoid follicles, and lymphocytic gastritis: a risk factor for the development of primary gastric lymphoma? ( 8707131 )
1996
50
Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis. ( 8567997 )
1995

Variations for Lymphocytic Gastritis

Expression for Lymphocytic Gastritis

Search GEO for disease gene expression data for Lymphocytic Gastritis.

Pathways for Lymphocytic Gastritis

Pathways related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 FAS FASLG GZMB
2
Show member pathways
12.37 FAS FASLG GZMB
3 12.09 FAS FASLG GZMB
4
Show member pathways
11.98 FAS FASLG GZMB
5
Show member pathways
11.89 FAS FASLG GZMB
6
Show member pathways
11.61 FASLG GZMB
7
Show member pathways
11.59 FAS FASLG GZMB
8
Show member pathways
11.47 FAS FASLG
9
Show member pathways
11.45 FAS FASLG
10 11.37 FAS FASLG
11
Show member pathways
11.26 FASLG GZMB
12 11.19 FAS FASLG GZMB TIA1
13 11.16 FAS FASLG
14 11.08 FAS FASLG
15 10.91 FAS FASLG
16
Show member pathways
10.69 FAS FASLG GZMB

GO Terms for Lymphocytic Gastritis

Biological processes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor-mediated signaling pathway GO:0033209 9.46 FAS FASLG
2 apoptotic process GO:0006915 9.46 FAS FASLG GZMB TIA1
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.43 FAS FASLG
4 apoptotic signaling pathway GO:0097190 9.4 FAS FASLG
5 extrinsic apoptotic signaling pathway GO:0097191 9.37 FAS FASLG
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.32 FAS FASLG
7 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.26 FAS FASLG
8 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 8.96 FAS FASLG
9 necroptotic signaling pathway GO:0097527 8.62 FAS FASLG

Sources for Lymphocytic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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