MCID: LYM015
MIFTS: 31

Lymphocytic Gastritis

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Gastritis

MalaCards integrated aliases for Lymphocytic Gastritis:

Name: Lymphocytic Gastritis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4035
NCIt 47 C27051
SNOMED-CT 64 235658000 360375007
UMLS 69 C1283271

Summaries for Lymphocytic Gastritis

MalaCards based summary : Lymphocytic Gastritis is related to gastritis and hypoglycemia. An important gene associated with Lymphocytic Gastritis is GZMB (Granzyme B), and among its related pathways/superpathways are Allograft rejection and Apoptosis Modulation and Signaling. The drugs Esomeprazole and Antacids have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related phenotype is Synthetic lethal with MLN4924 (a NAE inhibitor).

Related Diseases for Lymphocytic Gastritis

Diseases related to Lymphocytic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 gastritis 10.5
2 hypoglycemia 10.3 GZMB TIA1
3 male infertility 10.3 GZMB TIA1
4 succinic acidemia lactic acidosis congenital 10.3 GZMB TIA1
5 rubella panencephalitis 10.3 GZMB TIA1
6 congenital sucrase-isomaltase deficiency with starch intolerance 10.3 GZMB TIA1
7 pediatric lymphoma 10.3 GZMB TIA1
8 renal hypertension 10.3 GZMB TIA1
9 polycystic ovary syndrome 10.2 GZMB TIA1
10 mucinous intrahepatic cholangiocarcinoma 10.2 GZMB TIA1
11 plasmodium ovale malaria 10.2 GZMB TIA1
12 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 GZMB TIA1
13 pyridoxine-responsive sideroblastic anemia 10.0 GZMB TIA1
14 celiac disease 10.0
15 spinal cancer 10.0 FASLG GZMB
16 paramyloidosis 10.0 FASLG GZMB
17 lymphoma 9.9
18 bolivian hemorrhagic fever 9.9 FASLG GZMB
19 acute monoblastic leukemia 9.9 FASLG GZMB
20 epstein-barr virus, susceptibility to chronic infection by 9.9 GZMB TIA1
21 screw worm infectious disease 9.9 FASLG GZMB
22 duodenal somatostatinoma 9.9 B3GAT1 FASLG
23 intestinal disaccharidase deficiency 9.8 FASLG GZMB
24 gastric lymphoma 9.8
25 adenocarcinoma 9.8
26 juvenile sialidosis type 2 9.8 FAS FASLG
27 clivus chondroid chordoma 9.8 B3GAT1 GZMB TIA1
28 breast fibroadenosis 9.8 B3GAT1 GZMB TIA1
29 metaphyseal dysplasia without hypotrichosis 9.8 FAS FASLG
30 loeffler endocarditis 9.8 FAS FASLG
31 breast adenomyoepithelioma 9.7 FAS FASLG
32 gastric adenocarcinoma 9.7
33 autosomal recessive leukoencephalopathy-ischemic stroke-retinitis pigmentosa syndrome 9.7 FAS FASLG
34 cervical benign neoplasm 9.7 FAS FASLG
35 mixed cell type cancer 9.7 FAS GZMB TIA1
36 sinusitis 9.7 FAS FASLG
37 carnitine-acylcarnitine translocase deficiency 9.7 FAS GZMB TIA1
38 asbestosis 9.6 FAS FASLG
39 childhood testicular mixed germ cell tumor 9.6 FAS FASLG
40 noninfectious dermatoses of eyelid 9.6 FAS FASLG
41 deficiency anemia 9.6
42 acne 9.6
43 vitamin b12 deficiency 9.6
44 mucositis 9.6
45 gastric ulcer 9.6
46 iron deficiency anemia 9.6
47 dyspepsia 9.6
48 intestinal disease 9.6
49 duodenitis 9.6
50 vasculitis 9.6

Graphical network of the top 20 diseases related to Lymphocytic Gastritis:



Diseases related to Lymphocytic Gastritis

Symptoms & Phenotypes for Lymphocytic Gastritis

GenomeRNAi Phenotypes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

Drugs & Therapeutics for Lymphocytic Gastritis

Drugs for Lymphocytic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578
2 Antacids Phase 3
3 Anti-Ulcer Agents Phase 3
4 Gastrointestinal Agents Phase 3
5
Proton pump inhibitors Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Esomeprazole Treatment for Patients With Lymphocytic Gastritis Unknown status NCT00455754 Phase 3 Esomeprazole
2 Lymphocytic Subsets and Cytokine Production With H. Pylori Infection Completed NCT00173953

Search NIH Clinical Center for Lymphocytic Gastritis

Genetic Tests for Lymphocytic Gastritis

Anatomical Context for Lymphocytic Gastritis

MalaCards organs/tissues related to Lymphocytic Gastritis:

39
T Cells

Publications for Lymphocytic Gastritis

Articles related to Lymphocytic Gastritis:

(show top 50) (show all 76)
id Title Authors Year
1
Recurrent anaemia in a patient with lymphocytic gastritis and vitamin B12 deficiency. ( 28943131 )
2017
2
Development of lymphocytic gastritis with recurrent Helicobacter pylori infection. ( 28211221 )
2017
3
Lymphocytic Gastritis Identified by Abnormal PET Scan. ( 28462239 )
2017
4
Propionibacterium acnes overabundance and NKG2D system activation in corpus-dominant lymphocytic gastritis. ( 27538697 )
2016
5
Lymphocytic gastritis: clinical, endoscopic and histopathologic features. ( 27532536 )
2016
6
Letter: lymphocytic gastritis and coeliac disease - authors' reply. ( 26331559 )
2015
7
Letter: lymphocytic gastritis and coeliac disease. ( 26331558 )
2015
8
Lymphocytic gastritis is not associated with active Helicobacter pylori infection. ( 24826984 )
2014
9
Pathology in practice. Severe gastric submucosal edema, with vasculitis, fibrinoid degeneration, and mild eosinophilic and lymphocytic gastritis. ( 24649989 )
2014
10
Helicobacter pylori Associated Lymphocytic Gastritis in a Child. ( 25349835 )
2014
11
Lymphocytic gastritis showing concomitant occurrence of both CD4 + and CD8 + T-cells among epithelial cells. ( 25047508 )
2014
12
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. ( 23528908 )
2013
13
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis. ( 23716104 )
2013
14
High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis. ( 23356909 )
2013
15
Lymphocytic gastritis in pediatric celiac disease. ( 21244234 )
2011
16
Endoscopic portrayal of lymphocytic gastritis in a child. ( 20639772 )
2010
17
The frequency of lymphocytic gastritis in baboons. ( 18396790 )
2008
18
Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation. ( 18979579 )
2008
19
The immunohistochemistry profile of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and inflammation. ( 18274643 )
2007
20
Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy--a randomized, double-blind, placebo-controlled multicentre trial. ( 16441467 )
2006
21
Lymphocytic gastritis in Helicobacter pylori-positive gastric MALT lymphoma--report of two cases. ( 15908769 )
2005
22
Lymphocytic gastritis in pediatric celiac disease -- immunohistochemical study of the intraepithelial lymphocytic component. ( 14704635 )
2004
23
Resolution of gastrointestinal protein loss after Helicobacter pylori eradication in a patient with hypertrophic lymphocytic gastritis. ( 15610076 )
2004
24
Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence. ( 15509690 )
2004
25
Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: effect of H pylori treatment. ( 14669318 )
2003
26
Healing of lymphocytic gastritis by eradication of Helicobacter pylori. ( 11173895 )
2001
27
Collagenous gastritis associated with lymphocytic gastritis and celiac disease. ( 11735694 )
2001
28
Treatment of Helicobacter pylori in patients with lymphocytic gastritis. ( 11490827 )
2001
29
Clinical and endoscopic improvement of lymphocytic gastritis with eradication of Helicobacter pylori. ( 11474405 )
2001
30
Lymphocytic gastritis and protein-losing gastropathy. ( 11030189 )
2000
31
Lymphocytic gastritis and Helicobacter pylori: reluctant mucosal partners? ( 11179991 )
2000
32
Lymphocytic gastritis, Helicobacter pylori, and gastric cancer: is vitamin C the common link? ( 10355855 )
1999
33
The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology. ( 10690170 )
1999
34
Effects of Helicobacter pylori eradication on the natural history of lymphocytic gastritis. ( 10486354 )
1999
35
Lymphocytic gastritis: association with etiology and topology. ( 9989841 )
1999
36
High proportion of granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis. ( 9537473 )
1998
37
Hypertrophic lymphocytic gastritis with a gastric carcinoma. ( 9831277 )
1998
38
Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia. ( 9932632 )
1998
39
Lymphocytic gastritis and coeliac disease: evidence of a positive association. ( 9659261 )
1998
40
Lymphocytic gastritis and Helicobacter pylori: a Brazilian survey. ( 9577382 )
1998
41
Lymphocytic gastritis: a study of its frequency and review of the literature. ( 9711310 )
1998
42
Lymphocytic gastritis resembling graft-vs.-host disease following autologous hematopoietic cell transplantation. ( 9701391 )
1998
43
Adenocarcinoma of the small bowel, coeliac disease, and lymphocytic gastritis. ( 10193339 )
1998
44
Successful treatment of protein-losing lymphocytic gastritis with omeprazole. ( 9451692 )
1997
45
Diagnostic criteria in lymphocytic gastritis. ( 9098036 )
1997
46
Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue. ( 9412920 )
1997
47
Lymphocytic gastritis and gastric permeability in patients with celiac disease. ( 8698227 )
1996
48
Association of Helicobacter pylori infection, lymphoid follicles, and lymphocytic gastritis: a risk factor for the development of primary gastric lymphoma? ( 8707131 )
1996
49
Lymphocytic gastritis and coeliac disease. ( 8707101 )
1996
50
Early gastric cancer in a patient with Menetrier's disease, lymphocytic gastritis and Helicobacter pylori. ( 7712313 )
1995

Variations for Lymphocytic Gastritis

Expression for Lymphocytic Gastritis

Search GEO for disease gene expression data for Lymphocytic Gastritis.

Pathways for Lymphocytic Gastritis

Pathways related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 15)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.43 FAS FASLG GZMB
2
Show member pathways
12.36 FAS FASLG GZMB
3 12.04 FAS FASLG GZMB
4
Show member pathways
11.91 FAS FASLG GZMB
5
Show member pathways
11.6 FASLG GZMB
6
Show member pathways
11.59 FAS FASLG GZMB
7
Show member pathways
11.46 FAS FASLG
8
Show member pathways
11.45 FAS FASLG
9 11.36 FAS FASLG
10
Show member pathways
11.24 FASLG GZMB
11 11.19 FAS FASLG GZMB TIA1
12 11.14 FAS FASLG
13 11.05 FAS FASLG
14 10.87 FAS FASLG
15
Show member pathways
10.73 FAS FASLG GZMB

GO Terms for Lymphocytic Gastritis

Biological processes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.56 FAS FASLG GZMB TIA1
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.49 FAS FASLG
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.48 FAS FASLG
4 apoptotic signaling pathway GO:0097190 9.46 FAS FASLG
5 extrinsic apoptotic signaling pathway GO:0097191 9.43 FAS FASLG
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.4 FAS FASLG
7 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.37 FAS FASLG
8 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.32 FAS FASLG
9 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.16 FAS FASLG
10 necroptotic signaling pathway GO:0097527 8.96 FAS FASLG
11 inflammatory cell apoptotic process GO:0006925 8.62 FAS FASLG

Sources for Lymphocytic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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