MCID: LYM015
MIFTS: 32

Lymphocytic Gastritis malady

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Gastritis

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Aliases & Descriptions for Lymphocytic Gastritis:

Name: Lymphocytic Gastritis 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:4035
NCIt45 C27051

Summaries for Lymphocytic Gastritis

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MalaCards based summary: Lymphocytic Gastritis is related to gastritis and male infertility. An important gene associated with Lymphocytic Gastritis is GZMB (Granzyme B), and among its related pathways are Innate Lymphoid Cell Differentiation Pathways and Signal transduction_JNK pathway. Affiliated tissues include t cells, and related mouse phenotype Synthetic lethal with MLN4924 (a NAE inhibitor).

Related Diseases for Lymphocytic Gastritis

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Diseases related to Lymphocytic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis10.5
2male infertility10.3GZMB, TIA1
3eosinophilia10.3GZMB, TIA1
4subependymal nodular heterotopia10.3GZMB, TIA1
5pseudotyphus of california10.3GZMB, TIA1
6diffuse large b-cell lymphoma with chronic inflammation10.3GZMB, TIA1
7polycystic ovary syndrome10.3GZMB, TIA1
8gray zone lymphoma10.3GZMB, TIA1
9renal hypertension10.3GZMB, TIA1
10lumbosacral lipoma10.3GZMB, TIA1
11mixed cell type cancer10.3GZMB, TIA1
12lacrimal passage granuloma10.3GZMB, TIA1
13sezary's disease10.2GZMB, TIA1
14sialolithiasis10.2GZMB, TIA1
15estrogen-receptor positive breast cancer10.2GZMB, TIA1
16tonsillar fossa cancer10.2FAS, GZMB
17trigeminal nerve disease10.2FASLG, GZMB
1812p12.1 microdeletion syndrome10.1FAS, FASLG
19bolivian hemorrhagic fever10.1FASLG, GZMB
20pediatric systemic lupus erythematosus10.1FAS, FASLG
21adrenal cortical adenocarcinoma10.0FAS, FASLG
22lacrimal system cancer10.0CD8A, FAS
23metaphyseal dysplasia without hypotrichosis10.0FAS, FASLG
24celiac disease10.0
25conjunctival pigmentation10.0CD8A, FAS
26lens disease10.0CD8A, FASLG
27cardiac granular cell neoplasm9.9B3GAT1, GZMB
28lymphoma9.9
29sinusitis9.9FAS, FASLG
30hepatitis b9.9FAS, GZMB
31chediak-higashi syndrome9.9CD8A, FASLG
32paramyloidosis9.9B3GAT1, CD8A
33aorta atresia9.9CD8A, GZMB, TIA1
34hodgkin lymphoma9.9FAS, GZMB, TIA1
35asbestosis9.9FAS, FASLG
36capgras syndrome9.8B3GAT1, CD8A
37childhood choriocarcinoma of the testis9.8FAS, FASLG
38gastric lymphoma9.8
39adenocarcinoma9.8
40testicular malignant germ cell cancer9.8FASLG, GZMB, TIA1
41eczematous dermatitis of eyelid9.8FAS, FASLG
42iridocyclitis9.8B3GAT1, CD8A
43hypodermyiasis9.7CD8A, FASLG, GZMB
44gastric cancer9.7
45gastric adenocarcinoma9.7
46hashimoto thyroiditis9.7FAS, FASLG
47epstein-barr virus, susceptibility to chronic infection by9.7GZMB, TIA1
48benign breast adenomyoepithelioma9.6CD8A, FAS, FASLG
49orofaciodigital syndrome iv9.6FAS, FASLG
50clivus chordoma9.6B3GAT1, GZMB, TIA1

Graphical network of the top 20 diseases related to Lymphocytic Gastritis:



Diseases related to lymphocytic gastritis

Symptoms & Phenotypes for Lymphocytic Gastritis

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GenomeRNAi Phenotypes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-18.5FAS, FASLG, GZMB, TIA1

Drugs & Therapeutics for Lymphocytic Gastritis

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Drugs for Lymphocytic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Esomeprazoleapproved, investigationalPhase 3324161796-78-7, 119141-88-74594, 9579578
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(-)-omeprazole
(S)-(-)-Omeprazole
(S)-(−)-omeprazole
(S)-Omeprazole
(S)-omeprazole
(s)-omeprazole
(−)-omeprazole
119141-88-7
119141-89-8
131959-78-9
172964-80-6
193469-77-1
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
326602-80-6
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1-methyl-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Axagon
BIDD:GT0020
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:50275
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CID9568614
CID9579578
CPD000058847
Ceprandal
D00455
D07917
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Erbolin
Esomeprazol
Esomeprazole
Esomeprazole (INN)
Esomeprazole Sodium
Esomeprazole [INN:BAN]
Esomeprazolum
Esomperazole
Esopral
Exter
Gasec
Gastrimut
Gastroloc
Gibancer
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
I06-0705
IDI1_032523
InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20
Indurgan
Inexium paranova
Inexium paranova (TN)
Inhibitron
Inhipump
LS-185188
LS-7629
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Mepral
 
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
MolPort-005-943-880
Mopral
Morecon
NCGC00016925-01
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium Control
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMZ
Ocid
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole (JAN/USP/INN)
Omeprazole S-form
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Perprazole
Prazentol
Prazidec
Prazolit
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
TL8005099
Tedec Ulceral
UNII-KG60484QX9
UNII-N3PA6559FT
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
ZINC04693574
ZINC04693575
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
esomeprazole
esomeprazolum
omeprazole
Ésoméprazole
2
Proton pump inhibitorsPhase 31080
Synonyms:
 
PPIs
3Gastrointestinal AgentsPhase 38109
4AntacidsPhase 31767
5Anti-Ulcer AgentsPhase 31767

Interventional clinical trials:

idNameStatusNCT IDPhase
1Esomeprazole Treatment for Patients With Lymphocytic GastritisUnknown statusNCT00455754Phase 3
2Lymphocytic Subsets and Cytokine Production With H. Pylori InfectionCompletedNCT00173953

Search NIH Clinical Center for Lymphocytic Gastritis

Genetic Tests for Lymphocytic Gastritis

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Anatomical Context for Lymphocytic Gastritis

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MalaCards organs/tissues related to Lymphocytic Gastritis:

36
T cells

Publications for Lymphocytic Gastritis

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Articles related to Lymphocytic Gastritis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Propionibacterium acnes overabundance and NKG2D system activation in corpus-dominant lymphocytic gastritis. (27538697)
2016
2
Lymphocytic gastritis: clinical, endoscopic and histopathologic features. (27532536)
2016
3
Letter: lymphocytic gastritis and coeliac disease. (26331558)
2015
4
Letter: lymphocytic gastritis and coeliac disease - authors' reply. (26331559)
2015
5
Lymphocytic gastritis showing concomitant occurrence of both CD4 + and CD8 + T-cells among epithelial cells. (25047508)
2014
6
Pathology in practice. Severe gastric submucosal edema, with vasculitis, fibrinoid degeneration, and mild eosinophilic and lymphocytic gastritis. (24649989)
2014
7
Lymphocytic gastritis is not associated with active Helicobacter pylori infection. (24826984)
2014
8
Helicobacter pylori Associated Lymphocytic Gastritis in a Child. (25349835)
2014
9
High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis. (23356909)
2013
10
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. (23528908)
2013
11
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis. (23716104)
2013
12
Lymphocytic gastritis in pediatric celiac disease. (21244234)
2011
13
Endoscopic portrayal of lymphocytic gastritis in a child. (20639772)
2010
14
Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation. (18979579)
2008
15
The frequency of lymphocytic gastritis in baboons. (18396790)
2008
16
The immunohistochemistry profile of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and inflammation. (18274643)
2007
17
Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy--a randomized, double-blind, placebo-controlled multicentre trial. (16441467)
2006
18
Lymphocytic gastritis in Helicobacter pylori-positive gastric MALT lymphoma--report of two cases. (15908769)
2005
19
Resolution of gastrointestinal protein loss after Helicobacter pylori eradication in a patient with hypertrophic lymphocytic gastritis. (15610076)
2004
20
Lymphocytic gastritis in pediatric celiac disease -- immunohistochemical study of the intraepithelial lymphocytic component. (14704635)
2004
21
Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence. (15509690)
2004
22
Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: effect of H pylori treatment. (14669318)
2003
23
Collagenous gastritis associated with lymphocytic gastritis and celiac disease. (11735694)
2001
24
Treatment of Helicobacter pylori in patients with lymphocytic gastritis. (11490827)
2001
25
Clinical and endoscopic improvement of lymphocytic gastritis with eradication of Helicobacter pylori. (11474405)
2001
26
Healing of lymphocytic gastritis by eradication of Helicobacter pylori. (11173895)
2001
27
Lymphocytic gastritis and protein-losing gastropathy. (11030189)
2000
28
Lymphocytic gastritis and Helicobacter pylori: reluctant mucosal partners? (11179991)
2000
29
Lymphocytic gastritis: association with etiology and topology. (9989841)
1999
30
The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology. (10690170)
1999
31
Effects of Helicobacter pylori eradication on the natural history of lymphocytic gastritis. (10486354)
1999
32
Lymphocytic gastritis, Helicobacter pylori, and gastric cancer: is vitamin C the common link? (10355855)
1999
33
Lymphocytic gastritis and coeliac disease: evidence of a positive association. (9659261)
1998
34
Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia. (9932632)
1998
35
Adenocarcinoma of the small bowel, coeliac disease, and lymphocytic gastritis. (10193339)
1998
36
Lymphocytic gastritis and Helicobacter pylori: a Brazilian survey. (9577382)
1998
37
Hypertrophic lymphocytic gastritis with a gastric carcinoma. (9831277)
1998
38
Lymphocytic gastritis: a study of its frequency and review of the literature. (9711310)
1998
39
Lymphocytic gastritis resembling graft-vs.-host disease following autologous hematopoietic cell transplantation. (9701391)
1998
40
High proportion of granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis. (9537473)
1998
41
Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue. (9412920)
1997
42
Successful treatment of protein-losing lymphocytic gastritis with omeprazole. (9451692)
1997
43
Diagnostic criteria in lymphocytic gastritis. (9098036)
1997
44
Association of Helicobacter pylori infection, lymphoid follicles, and lymphocytic gastritis: a risk factor for the development of primary gastric lymphoma? (8707131)
1996
45
Lymphocytic gastritis and coeliac disease. (8707101)
1996
46
Lymphocytic gastritis and gastric permeability in patients with celiac disease. (8698227)
1996
47
Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis. (8567997)
1995
48
A retrospective study on the incidence of lymphocytic gastritis in patients with Helicobacter pylori infection. (8545561)
1995
49
Lymphocytic gastritis and associated small bowel disease: a diffuse lymphocytic gastroenteropathy? (8537495)
1995
50
Lymphocytic gastritis. Clinical and endoscopic presentation and long-term follow-up. (7571985)
1995

Variations for Lymphocytic Gastritis

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Expression for genes affiliated with Lymphocytic Gastritis

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Search GEO for disease gene expression data for Lymphocytic Gastritis.

Pathways for genes affiliated with Lymphocytic Gastritis

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Pathways related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.5CD8A, GZMB
29.3FAS, FASLG
39.3FAS, FASLG
4
Show member pathways
8.9FAS, FASLG, GZMB
5
Show member pathways
8.9FAS, FASLG, GZMB
6
Show member pathways
8.9FAS, FASLG, GZMB
7
Show member pathways
8.9FAS, FASLG, GZMB
8
Show member pathways
8.9FAS, FASLG, GZMB
9
Show member pathways
8.9FAS, FASLG, GZMB
10
Show member pathways
8.9CD8A, FASLG, GZMB
11
Show member pathways
8.9CD8A, FASLG, GZMB
128.5FAS, FASLG, GZMB, TIA1
13
Show member pathways
8.4CD8A, FAS, FASLG, GZMB
148.4CD8A, FAS, FASLG, GZMB

GO Terms for genes affiliated with Lymphocytic Gastritis

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Cellular components related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.4CD8A, FAS, FASLG
2external side of plasma membraneGO:00098978.8CD8A, FAS, FASLG

Biological processes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.1FAS, FASLG
2activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.1FAS, FASLG
3apoptotic signaling pathwayGO:009719010.0FAS, FASLG
4extrinsic apoptotic signaling pathwayGO:009719110.0FAS, FASLG
5extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.0FAS, FASLG
6inflammatory cell apoptotic processGO:00069259.8FAS, FASLG
7necroptotic signaling pathwayGO:00975279.8FAS, FASLG
8negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.7FAS, FASLG
9regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.6FAS, FASLG
10response to growth factorGO:00708489.3FAS, FASLG
11immune responseGO:00069559.3CD8A, FAS, FASLG
12apoptotic processGO:00069159.1FAS, FASLG, GZMB, TIA1

Sources for Lymphocytic Gastritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet