MCID: LYM015
MIFTS: 31

Lymphocytic Gastritis malady

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Gastritis

Aliases & Descriptions for Lymphocytic Gastritis:

Name: Lymphocytic Gastritis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4035
NCIt 47 C27051
SNOMED-CT 64 235658000 360375007
UMLS 69 C1283271

Summaries for Lymphocytic Gastritis

MalaCards based summary : Lymphocytic Gastritis is related to gastritis and malignant glioma. An important gene associated with Lymphocytic Gastritis is GZMB (Granzyme B), and among its related pathways/superpathways are Allograft rejection and Apoptosis Modulation and Signaling. The drugs Esomeprazole and Antacids have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related phenotype is Synthetic lethal with MLN4924 (a NAE inhibitor).

Related Diseases for Lymphocytic Gastritis

Diseases related to Lymphocytic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
id Related Disease Score Top Affiliating Genes
1 gastritis 10.5
2 malignant glioma 10.1 GZMB TIA1
3 alström syndrome 10.1 GZMB TIA1
4 superior limbic keratoconjunctivitis 10.1 GZMB TIA1
5 collagen type iii glomerulopathy 10.1 GZMB TIA1
6 uterine ligament endometrioid adenocarcinoma 10.1 GZMB TIA1
7 congenital sucrase-isomaltase deficiency with starch and lactose intolerance 10.1 GZMB TIA1
8 linear lichen planus 10.1 GZMB TIA1
9 cerebral lipidosis 10.1 GZMB TIA1
10 post-transplant lymphoproliferative disease 10.1 GZMB TIA1
11 childhood immature teratoma of ovary 10.1 GZMB TIA1
12 plasmodium ovale malaria 10.1 GZMB TIA1
13 lip cancer 10.1 GZMB TIA1
14 aortic arch interruption 10.0 GZMB TIA1
15 histiocytic and dendritic cell cancer 10.0 FASLG GZMB
16 adenylosuccinase lyase deficiency 10.0 FASLG GZMB
17 pre-malignant neoplasm 10.0 GZMB TIA1
18 celiac disease 10.0
19 venezuelan hemorrhagic fever 10.0 FASLG GZMB
20 acute myeloid leukemia with recurrent genetic anomaly 10.0 FASLG GZMB
21 periodontosis 10.0 FASLG GZMB
22 active peptic ulcer disease 10.0 B3GAT1 FASLG
23 midline interhemispheric variant of holoprosencephaly 10.0 FAS FASLG
24 tibial adamantinoma 9.9 B3GAT1 GZMB TIA1
25 anauxetic dysplasia 9.9 FAS FASLG
26 fibrosclerosis of breast 9.9 B3GAT1 GZMB TIA1
27 coarctation of aorta 9.9 GZMB TIA1
28 hereditary ataxia 9.9 FAS GZMB
29 trabecular follicular adenocarcinoma 9.9 FAS FASLG
30 lymphoma 9.9
31 pseudo-meigs syndrome 9.9 FAS FASLG
32 breast adenomyoepithelioma 9.9 FAS FASLG
33 skin conditions 9.9 FAS FASLG
34 carnitine-acylcarnitine translocase deficiency 9.9 FAS GZMB TIA1
35 baritosis 9.9 FAS FASLG
36 pituitary carcinoma 9.9 FAS FASLG
37 prostatic urethral cancer 9.9 FAS FASLG
38 noninfectious dermatoses of eyelid 9.9 FAS FASLG
39 autosomal dominant robinow syndrome 3 9.8 FAS FASLG
40 malignant teratoma 9.8 FASLG GZMB TIA1
41 hyperaldosteronism, familial, type ii 9.8 FASLG GZMB TIA1
42 gastric lymphoma 9.8
43 adenocarcinoma 9.8
44 joubert syndrome 18 9.8 FAS FASLG
45 psoriasis susceptibility 1 9.8 FAS FASLG GZMB
46 gastric cancer 9.7
47 gastric adenocarcinoma 9.7
48 diabetes mellitus, insulin-dependent, 12 9.7 FAS FASLG
49 macrogyria, pseudobulbar palsy and mental retardation 9.6 FAS FASLG GZMB TIA1
50 mixed cell type cancer 9.6 FAS FASLG GZMB TIA1

Graphical network of the top 20 diseases related to Lymphocytic Gastritis:



Diseases related to Lymphocytic Gastritis

Symptoms & Phenotypes for Lymphocytic Gastritis

GenomeRNAi Phenotypes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

Drugs & Therapeutics for Lymphocytic Gastritis

Drugs for Lymphocytic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578
2 Antacids Phase 3
3 Anti-Ulcer Agents Phase 3
4 Gastrointestinal Agents Phase 3
5
Proton pump inhibitors Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Esomeprazole Treatment for Patients With Lymphocytic Gastritis Unknown status NCT00455754 Phase 3
2 Lymphocytic Subsets and Cytokine Production With H. Pylori Infection Completed NCT00173953

Search NIH Clinical Center for Lymphocytic Gastritis

Genetic Tests for Lymphocytic Gastritis

Anatomical Context for Lymphocytic Gastritis

MalaCards organs/tissues related to Lymphocytic Gastritis:

39
T Cells

Publications for Lymphocytic Gastritis

Articles related to Lymphocytic Gastritis:

(show top 50) (show all 73)
id Title Authors Year
1
Lymphocytic gastritis: clinical, endoscopic and histopathologic features. ( 27532536 )
2016
2
Propionibacterium acnes overabundance and NKG2D system activation in corpus-dominant lymphocytic gastritis. ( 27538697 )
2016
3
Letter: lymphocytic gastritis and coeliac disease - authors' reply. ( 26331559 )
2015
4
Letter: lymphocytic gastritis and coeliac disease. ( 26331558 )
2015
5
Pathology in practice. Severe gastric submucosal edema, with vasculitis, fibrinoid degeneration, and mild eosinophilic and lymphocytic gastritis. ( 24649989 )
2014
6
Lymphocytic gastritis showing concomitant occurrence of both CD4 + and CD8 + T-cells among epithelial cells. ( 25047508 )
2014
7
Helicobacter pylori Associated Lymphocytic Gastritis in a Child. ( 25349835 )
2014
8
Lymphocytic gastritis is not associated with active Helicobacter pylori infection. ( 24826984 )
2014
9
High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis. ( 23356909 )
2013
10
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. ( 23528908 )
2013
11
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis. ( 23716104 )
2013
12
Lymphocytic gastritis in pediatric celiac disease. ( 21244234 )
2011
13
Endoscopic portrayal of lymphocytic gastritis in a child. ( 20639772 )
2010
14
Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation. ( 18979579 )
2008
15
The frequency of lymphocytic gastritis in baboons. ( 18396790 )
2008
16
The immunohistochemistry profile of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and inflammation. ( 18274643 )
2007
17
Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy--a randomized, double-blind, placebo-controlled multicentre trial. ( 16441467 )
2006
18
Lymphocytic gastritis in Helicobacter pylori-positive gastric MALT lymphoma--report of two cases. ( 15908769 )
2005
19
Lymphocytic gastritis in pediatric celiac disease -- immunohistochemical study of the intraepithelial lymphocytic component. ( 14704635 )
2004
20
Resolution of gastrointestinal protein loss after Helicobacter pylori eradication in a patient with hypertrophic lymphocytic gastritis. ( 15610076 )
2004
21
Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence. ( 15509690 )
2004
22
Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: effect of H pylori treatment. ( 14669318 )
2003
23
Clinical and endoscopic improvement of lymphocytic gastritis with eradication of Helicobacter pylori. ( 11474405 )
2001
24
Treatment of Helicobacter pylori in patients with lymphocytic gastritis. ( 11490827 )
2001
25
Healing of lymphocytic gastritis by eradication of Helicobacter pylori. ( 11173895 )
2001
26
Collagenous gastritis associated with lymphocytic gastritis and celiac disease. ( 11735694 )
2001
27
Lymphocytic gastritis and Helicobacter pylori: reluctant mucosal partners? ( 11179991 )
2000
28
Lymphocytic gastritis and protein-losing gastropathy. ( 11030189 )
2000
29
Lymphocytic gastritis: association with etiology and topology. ( 9989841 )
1999
30
Effects of Helicobacter pylori eradication on the natural history of lymphocytic gastritis. ( 10486354 )
1999
31
The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology. ( 10690170 )
1999
32
Lymphocytic gastritis, Helicobacter pylori, and gastric cancer: is vitamin C the common link? ( 10355855 )
1999
33
High proportion of granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis. ( 9537473 )
1998
34
Hypertrophic lymphocytic gastritis with a gastric carcinoma. ( 9831277 )
1998
35
Lymphocytic gastritis resembling graft-vs.-host disease following autologous hematopoietic cell transplantation. ( 9701391 )
1998
36
Lymphocytic gastritis: a study of its frequency and review of the literature. ( 9711310 )
1998
37
Lymphocytic gastritis and Helicobacter pylori: a Brazilian survey. ( 9577382 )
1998
38
Adenocarcinoma of the small bowel, coeliac disease, and lymphocytic gastritis. ( 10193339 )
1998
39
Lymphocytic gastritis and coeliac disease: evidence of a positive association. ( 9659261 )
1998
40
Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia. ( 9932632 )
1998
41
Successful treatment of protein-losing lymphocytic gastritis with omeprazole. ( 9451692 )
1997
42
Diagnostic criteria in lymphocytic gastritis. ( 9098036 )
1997
43
Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue. ( 9412920 )
1997
44
Association of Helicobacter pylori infection, lymphoid follicles, and lymphocytic gastritis: a risk factor for the development of primary gastric lymphoma? ( 8707131 )
1996
45
Lymphocytic gastritis and gastric permeability in patients with celiac disease. ( 8698227 )
1996
46
Lymphocytic gastritis and coeliac disease. ( 8707101 )
1996
47
Lymphocytic gastritis and Helicobacter pylori infection in gastric lymphoma. ( 7489930 )
1995
48
Lymphocytic gastritis and associated small bowel disease: a diffuse lymphocytic gastroenteropathy? ( 8537495 )
1995
49
Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis. ( 8567997 )
1995
50
Lymphocytic gastritis. Clinical and endoscopic presentation and long-term follow-up. ( 7571985 )
1995

Variations for Lymphocytic Gastritis

Expression for Lymphocytic Gastritis

Search GEO for disease gene expression data for Lymphocytic Gastritis.

Pathways for Lymphocytic Gastritis

Pathways related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 FAS FASLG GZMB
2
Show member pathways
12.39 FAS FASLG GZMB
3 12.08 FAS FASLG GZMB
4
Show member pathways
11.98 FAS FASLG GZMB
5
Show member pathways
11.89 FAS FASLG GZMB
6
Show member pathways
11.61 FASLG GZMB
7
Show member pathways
11.59 FAS FASLG GZMB
8
Show member pathways
11.48 FAS FASLG
9
Show member pathways
11.46 FAS FASLG
10 11.36 FAS FASLG
11
Show member pathways
11.26 FASLG GZMB
12 11.19 FAS FASLG GZMB TIA1
13 11.16 FAS FASLG
14 11.08 FAS FASLG
15 10.91 FAS FASLG
16
Show member pathways
10.73 FAS FASLG GZMB

GO Terms for Lymphocytic Gastritis

Biological processes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.56 FAS FASLG GZMB TIA1
2 tumor necrosis factor-mediated signaling pathway GO:0033209 9.49 FAS FASLG
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.48 FAS FASLG
4 apoptotic signaling pathway GO:0097190 9.46 FAS FASLG
5 extrinsic apoptotic signaling pathway GO:0097191 9.43 FAS FASLG
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.4 FAS FASLG
7 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.37 FAS FASLG
8 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.32 FAS FASLG
9 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.16 FAS FASLG
10 necroptotic signaling pathway GO:0097527 8.96 FAS FASLG
11 inflammatory cell apoptotic process GO:0006925 8.62 FAS FASLG

Sources for Lymphocytic Gastritis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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