MCID: LYM015
MIFTS: 31

Lymphocytic Gastritis malady

Categories: Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Lymphocytic Gastritis

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Aliases & Descriptions for Lymphocytic Gastritis:

Name: Lymphocytic Gastritis 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:4035
NCIt45 C27051

Summaries for Lymphocytic Gastritis

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MalaCards based summary: Lymphocytic Gastritis is related to gastritis and malignant glioma. An important gene associated with Lymphocytic Gastritis is GZMB (Granzyme B), and among its related pathways are Downstream signaling in naive CD8+ T cells and IL12-mediated signaling events. Affiliated tissues include t cells, and related mouse phenotype Synthetic lethal with MLN4924 (a NAE inhibitor).

Related Diseases for Lymphocytic Gastritis

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Diseases related to Lymphocytic Gastritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis10.5
2malignant glioma10.1GZMB, TIA1
3alström syndrome10.1GZMB, TIA1
4superior limbic keratoconjunctivitis10.1GZMB, TIA1
5collagen type iii glomerulopathy10.1GZMB, TIA1
6uterine ligament endometrioid adenocarcinoma10.1GZMB, TIA1
7congenital sucrase-isomaltase deficiency with starch and lactose intolerance10.1GZMB, TIA1
8linear lichen planus10.1GZMB, TIA1
9cerebral lipidosis10.1GZMB, TIA1
10post-transplant lymphoproliferative disease10.1GZMB, TIA1
11childhood immature teratoma of ovary10.1GZMB, TIA1
12plasmodium ovale malaria10.1GZMB, TIA1
13lip cancer10.1GZMB, TIA1
14aortic arch interruption10.0GZMB, TIA1
15histiocytic and dendritic cell cancer10.0FASLG, GZMB
16adenylosuccinase lyase deficiency10.0FASLG, GZMB
17pre-malignant neoplasm10.0GZMB, TIA1
18celiac disease10.0
19venezuelan hemorrhagic fever10.0FASLG, GZMB
20acute myeloid leukemia with recurrent genetic anomaly10.0FASLG, GZMB
21periodontosis10.0FASLG, GZMB
22active peptic ulcer disease10.0B3GAT1, FASLG
23midline interhemispheric variant of holoprosencephaly10.0FAS, FASLG
24tibial adamantinoma9.9B3GAT1, GZMB, TIA1
25anauxetic dysplasia9.9FAS, FASLG
26fibrosclerosis of breast9.9B3GAT1, GZMB, TIA1
27coarctation of aorta9.9GZMB, TIA1
28hereditary ataxia9.9FAS, GZMB
29trabecular follicular adenocarcinoma9.9FAS, FASLG
30lymphoma9.9
31pseudo-meigs syndrome9.9FAS, FASLG
32breast adenomyoepithelioma9.9FAS, FASLG
33skin conditions9.9FAS, FASLG
34carnitine-acylcarnitine translocase deficiency9.9FAS, GZMB, TIA1
35baritosis9.9FAS, FASLG
36pituitary carcinoma9.9FAS, FASLG
37prostatic urethral cancer9.9FAS, FASLG
38noninfectious dermatoses of eyelid9.9FAS, FASLG
39autosomal dominant robinow syndrome 39.8FAS, FASLG
40malignant teratoma9.8FASLG, GZMB, TIA1
41hyperaldosteronism, familial, type ii9.8FASLG, GZMB, TIA1
42gastric lymphoma9.8
43adenocarcinoma9.8
44joubert syndrome 189.8FAS, FASLG
45psoriasis susceptibility 19.8FAS, FASLG, GZMB
46gastric cancer9.7
47gastric adenocarcinoma9.7
48diabetes mellitus, insulin-dependent, 129.7FAS, FASLG
49macrogyria, pseudobulbar palsy and mental retardation9.6FAS, FASLG, GZMB, TIA1
50mixed cell type cancer9.6FAS, FASLG, GZMB, TIA1

Graphical network of the top 20 diseases related to Lymphocytic Gastritis:



Diseases related to lymphocytic gastritis

Symptoms & Phenotypes for Lymphocytic Gastritis

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GenomeRNAi Phenotypes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-18.1FAS, FASLG, GZMB, TIA1

Drugs & Therapeutics for Lymphocytic Gastritis

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Drugs for Lymphocytic Gastritis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Esomeprazoleapproved, investigationalPhase 3333161796-78-7, 119141-88-74594, 9579578
Synonyms:
( -)-Omeprazole
(-)-Omeprazole
(-)-omeprazole
(S)-(-)-Omeprazole
(S)-(−)-omeprazole
(S)-Omeprazole
(S)-omeprazole
(s)-omeprazole
(−)-omeprazole
119141-88-7
119141-89-8
131959-78-9
172964-80-6
193469-77-1
2-(((3,5-Dimethyl-4-methoxy-2-pyridyl)methyl)sulfinyl)-5-methoxy-1H-benzimidazole
2-({[3,5-dimethyl-4-(methyloxy)pyridin-2-yl]methyl}sulfinyl)-5-(methyloxy)-1H-benzimidazole
326602-80-6
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-((S)-((4-methoxy-3,5-dimethyl-2-pyridyl)methyl)sulfinyl)benzimidazole
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole
5-Methoxy-2[(4-methoxy-3,5-dimethyl-2-pyridyl)methylsulfinyl]-1H-benzimidazole
5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1-methyl-1H-benzimidazole
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
6-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
6-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole
73590-58-6
AC-401
AC1L1IIJ
AGI-010
AKOS005066653
AULCER
Antra
Antra MUPS
Audazol
Axagon
BIDD:GT0020
BIDD:GT0189
BPBio1_000425
BRD-A55962179-001-04-9
BSPBio_000385
Belmazol
Bio-0888
C07324
CAS-73590-58-6
CCRIS 7099
CHEBI:50275
CHEBI:519601
CHEBI:7772
CHEMBL1503
CID4594
CID9568614
CID9579578
CPD000058847
Ceprandal
D00455
D07917
DB00338
DB00736
DM-3458
Danlox
Demeprazol
Desec
Dizprazol
Dudencer
Elgam
Emeproton
Emilok
Epirazole
Erbolin
Esomeprazol
Esomeprazole
Esomeprazole (INN)
Esomeprazole Sodium
Esomeprazole [INN:BAN]
Esomeprazolum
Esomperazole
Esopral
Exter
Gasec
Gastrimut
Gastroloc
Gibancer
H 168-68
H 168/68
H-168/68
H168/68
HMS1528I05
HMS1569D07
HMS2052G17
HMS2090E16
HMS2090F11
HSDB 3575
I06-0705
IDI1_032523
InChI=1/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20
Indurgan
Inexium paranova
Inexium paranova (TN)
Inhibitron
Inhipump
LS-185188
LS-7629
Lensor
Logastric
Lomac
Losec
Losec, Omesec, Prilosec, Zegerid, Omeprazole
Lucen
MLS000069373
MLS001076112
MLS001424148
Maybridge4_002645
Mepral
 
Miol
Miracid
MolPort-003-666-741
MolPort-003-807-515
MolPort-003-849-702
MolPort-005-943-880
Mopral
Morecon
NCGC00016925-01
NCGC00016925-02
NCGC00021522-03
NCGC00021522-04
NCGC00021522-05
Nexiam
Nexium
Nexium Control
Nexium IV
Nilsec
Nopramin
Nuclosina
O0359
O104_SIGMA
OMEP
OMZ
Ocid
Olexin
Olit
Omapren
Omebeta
Omebeta 20
Omed
Omegast
Omepradex
Omepral
Omeprazol
Omeprazol [INN-Spanish]
Omeprazole (JAN/USP/INN)
Omeprazole S-form
Omeprazole [USAN:INN:BAN:JAN]
Omeprazole delayed-release
Omeprazole magnesium
Omeprazolum
Omeprazolum [INN-Latin]
Omeprazon
Omeprazone
Omeprol
Omesek
Omez
Omezol
Omezolan
Omid
Omisec
Omizac
Ompanyt
Ortanol
Osiren
Ozoken
Paprazol
Parizac
Pepticum
Pepticus
Peptilcer
Perprazole
Prazentol
Prazidec
Prazolit
Prestwick0_000493
Prestwick1_000493
Prestwick2_000493
Prestwick3_000493
Prestwick_808
Prilosec
Prilosec (TN)
Prilosec OTC
Procelac
Proclor
Prysma
Ramezol
Regulacid
Result
S1389_Selleck
SAM001246900
SAN-15
SMR000058847
SPBio_002306
STK623746
Sanamidol
Secrepina
TL8005099
Tedec Ulceral
UNII-KG60484QX9
UNII-N3PA6559FT
UPCMLD-DP075
UPCMLD-DP075:001
Ulceral
Ulcesep
Ulcometion
Ulcozol
Ulcsep
Ulsen
Ultop
Ulzol
Victrix
ZINC04693574
ZINC04693575
Zefxon
Zegerid
Zepral
Zimor
Zoltum
esomeprazol
esomeprazole
esomeprazolum
omeprazole
Ésoméprazole
2
Proton pump inhibitorsPhase 31123
Synonyms:
 
PPIs
3Gastrointestinal AgentsPhase 38402
4AntacidsPhase 31842
5Anti-Ulcer AgentsPhase 31842

Interventional clinical trials:

idNameStatusNCT IDPhase
1Esomeprazole Treatment for Patients With Lymphocytic GastritisUnknown statusNCT00455754Phase 3
2Lymphocytic Subsets and Cytokine Production With H. Pylori InfectionCompletedNCT00173953

Search NIH Clinical Center for Lymphocytic Gastritis

Genetic Tests for Lymphocytic Gastritis

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Anatomical Context for Lymphocytic Gastritis

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MalaCards organs/tissues related to Lymphocytic Gastritis:

36
T cells

Publications for Lymphocytic Gastritis

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Articles related to Lymphocytic Gastritis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Lymphocytic gastritis: clinical, endoscopic and histopathologic features. (27532536)
2016
2
Propionibacterium acnes overabundance and NKG2D system activation in corpus-dominant lymphocytic gastritis. (27538697)
2016
3
Letter: lymphocytic gastritis and coeliac disease - authors' reply. (26331559)
2015
4
Letter: lymphocytic gastritis and coeliac disease. (26331558)
2015
5
Pathology in practice. Severe gastric submucosal edema, with vasculitis, fibrinoid degeneration, and mild eosinophilic and lymphocytic gastritis. (24649989)
2014
6
Lymphocytic gastritis showing concomitant occurrence of both CD4 + and CD8 + T-cells among epithelial cells. (25047508)
2014
7
Helicobacter pylori Associated Lymphocytic Gastritis in a Child. (25349835)
2014
8
Lymphocytic gastritis is not associated with active Helicobacter pylori infection. (24826984)
2014
9
High proportion of granzyme B+ intraepithelial lymphocytes contributes to epithelial apoptosis in Helicobacter pylori-associated lymphocytic gastritis. (23356909)
2013
10
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. (23528908)
2013
11
Endoscopic, ultrasonographic, and pathologic correlation of lymphocytic gastritis. (23716104)
2013
12
Lymphocytic gastritis in pediatric celiac disease. (21244234)
2011
13
Endoscopic portrayal of lymphocytic gastritis in a child. (20639772)
2010
14
Lymphocytic gastritis and celiac disease in indian children: evidence of a positive relation. (18979579)
2008
15
The frequency of lymphocytic gastritis in baboons. (18396790)
2008
16
The immunohistochemistry profile of lymphocytic gastritis in celiac disease and helicobacter pylori infection: interplay between infection and inflammation. (18274643)
2007
17
Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy--a randomized, double-blind, placebo-controlled multicentre trial. (16441467)
2006
18
Lymphocytic gastritis in Helicobacter pylori-positive gastric MALT lymphoma--report of two cases. (15908769)
2005
19
Lymphocytic gastritis in pediatric celiac disease -- immunohistochemical study of the intraepithelial lymphocytic component. (14704635)
2004
20
Resolution of gastrointestinal protein loss after Helicobacter pylori eradication in a patient with hypertrophic lymphocytic gastritis. (15610076)
2004
21
Lymphocytic gastritis-like T cell lymphoma: molecular evidence of an unusual recurrence. (15509690)
2004
22
Epithelial cell proliferation and glandular atrophy in lymphocytic gastritis: effect of H pylori treatment. (14669318)
2003
23
Clinical and endoscopic improvement of lymphocytic gastritis with eradication of Helicobacter pylori. (11474405)
2001
24
Treatment of Helicobacter pylori in patients with lymphocytic gastritis. (11490827)
2001
25
Healing of lymphocytic gastritis by eradication of Helicobacter pylori. (11173895)
2001
26
Collagenous gastritis associated with lymphocytic gastritis and celiac disease. (11735694)
2001
27
Lymphocytic gastritis and Helicobacter pylori: reluctant mucosal partners? (11179991)
2000
28
Lymphocytic gastritis and protein-losing gastropathy. (11030189)
2000
29
Lymphocytic gastritis: association with etiology and topology. (9989841)
1999
30
Effects of Helicobacter pylori eradication on the natural history of lymphocytic gastritis. (10486354)
1999
31
The pattern of involvement of the gastric mucosa in lymphocytic gastritis is predictive of the presence of duodenal pathology. (10690170)
1999
32
Lymphocytic gastritis, Helicobacter pylori, and gastric cancer: is vitamin C the common link? (10355855)
1999
33
High proportion of granzyme B-positive (activated) intraepithelial and lamina propria lymphocytes in lymphocytic gastritis. (9537473)
1998
34
Hypertrophic lymphocytic gastritis with a gastric carcinoma. (9831277)
1998
35
Lymphocytic gastritis resembling graft-vs.-host disease following autologous hematopoietic cell transplantation. (9701391)
1998
36
Lymphocytic gastritis: a study of its frequency and review of the literature. (9711310)
1998
37
Lymphocytic gastritis and Helicobacter pylori: a Brazilian survey. (9577382)
1998
38
Adenocarcinoma of the small bowel, coeliac disease, and lymphocytic gastritis. (10193339)
1998
39
Lymphocytic gastritis and coeliac disease: evidence of a positive association. (9659261)
1998
40
Spontaneous remission of hypertrophic lymphocytic gastritis associated with hypoproteinemia. (9932632)
1998
41
Successful treatment of protein-losing lymphocytic gastritis with omeprazole. (9451692)
1997
42
Diagnostic criteria in lymphocytic gastritis. (9098036)
1997
43
Massive bleeding from multiple gastric ulcerations in a patient with lymphocytic gastritis and celiac sprue. (9412920)
1997
44
Association of Helicobacter pylori infection, lymphoid follicles, and lymphocytic gastritis: a risk factor for the development of primary gastric lymphoma? (8707131)
1996
45
Lymphocytic gastritis and gastric permeability in patients with celiac disease. (8698227)
1996
46
Lymphocytic gastritis and coeliac disease. (8707101)
1996
47
Lymphocytic gastritis and Helicobacter pylori infection in gastric lymphoma. (7489930)
1995
48
Lymphocytic gastritis and associated small bowel disease: a diffuse lymphocytic gastroenteropathy? (8537495)
1995
49
Ten year follow up study of lymphocytic gastritis: further evidence on Helicobacter pylori as a cause of lymphocytic gastritis and corpus gastritis. (8567997)
1995
50
Lymphocytic gastritis. Clinical and endoscopic presentation and long-term follow-up. (7571985)
1995

Variations for Lymphocytic Gastritis

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Expression for genes affiliated with Lymphocytic Gastritis

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Search GEO for disease gene expression data for Lymphocytic Gastritis.

Pathways for genes affiliated with Lymphocytic Gastritis

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Pathways related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.2FASLG, GZMB
2
Show member pathways
9.2FASLG, GZMB
39.0FAS, FASLG
4
Show member pathways
9.0FAS, FASLG
59.0FAS, FASLG
6
Show member pathways
9.0FAS, FASLG
79.0FAS, FASLG
89.0FAS, FASLG
9
Show member pathways
8.6FAS, FASLG, GZMB
10
Show member pathways
8.6FAS, FASLG, GZMB
11
Show member pathways
8.6FAS, FASLG, GZMB
12
Show member pathways
8.6FAS, FASLG, GZMB
13
Show member pathways
8.6FAS, FASLG, GZMB
148.6FAS, FASLG, GZMB
15
Show member pathways
8.6FAS, FASLG, GZMB
168.1FAS, FASLG, GZMB, TIA1

GO Terms for genes affiliated with Lymphocytic Gastritis

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Biological processes related to Lymphocytic Gastritis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.7FAS, FASLG
2activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:00972969.7FAS, FASLG
3apoptotic signaling pathwayGO:00971909.6FAS, FASLG
4extrinsic apoptotic signaling pathwayGO:00971919.6FAS, FASLG
5extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.6FAS, FASLG
6inflammatory cell apoptotic processGO:00069259.6FAS, FASLG
7necroptotic signaling pathwayGO:00975279.6FAS, FASLG
8negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.6FAS, FASLG
9regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.6FAS, FASLG
10tumor necrosis factor-mediated signaling pathwayGO:00332099.0FAS, FASLG
11apoptotic processGO:00069158.7FAS, FASLG, GZMB, TIA1

Sources for Lymphocytic Gastritis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet