MCID: LYM043
MIFTS: 35

Lymphocytic Hypophysitis

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Lymphocytic Hypophysitis

MalaCards integrated aliases for Lymphocytic Hypophysitis:

Name: Lymphocytic Hypophysitis 49
Autoimmune Hypophysitis 49 69
Lymphocytic Hypopituitarism 69
Lyh 49
Lh 49

Classifications:



External Ids:

Summaries for Lymphocytic Hypophysitis

NIH Rare Diseases : 49 Lymphocytic hypophysitis (LH) is a condition in which the pituitary gland becomes infiltrated by lymphocytes, resulting in pituitary enlargement and impaired function. It most often occurs in women in late pregnancy or the postpartum period, but can also occur in prepubertal or post-menopausal women, and in men. Symptoms of LH may include headache, visual field impairment and more rarely, double vision (diplopia). The exact cause is unknown but is thought to be autoimmune-related. Although some cases resolve on their own or after a short course of steroids, other cases cause persistent problems even with aggressive medical or surgical treatment. Last updated: 10/1/2012

MalaCards based summary : Lymphocytic Hypophysitis, also known as autoimmune hypophysitis, is related to hypopituitarism and pituitary adenoma. An important gene associated with Lymphocytic Hypophysitis is ENO1 (Enolase 1), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Glucose metabolism. Affiliated tissues include pituitary, thyroid and eye.

Wikipedia : 72 Autoimmune hypophysitis or Lymphocytic hypophysitis is defined as inflammation of the pituitary gland... more...

Related Diseases for Lymphocytic Hypophysitis

Diseases related to Lymphocytic Hypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 hypopituitarism 30.1 GH1 POMC
2 pituitary adenoma 29.8 GH1 POMC
3 pituitary tumors 29.7 GH1 POMC
4 pituitary hormone deficiency, combined, 2 29.7 GH1 POMC
5 adenohypophysitis 29.6 GH1 POMC
6 functioning pituitary adenoma 29.6 GH1 POMC
7 adrenal gland hyperfunction 29.5 GH1 POMC
8 acth deficiency, isolated 29.4 POMC TBX19
9 hyperprolactinemia 29.4 GH1 POMC
10 acromegaly 29.1 GH1 POMC
11 leydig cell hypoplasia, type i 12.1
12 resistance to lh 12.0
13 male pseudohermaphroditism due to defective lh molecule 11.9
14 leydig cell hypoplasia 11.7
15 acth-independent macronodular adrenal hyperplasia 11.0
16 hypogonadotropic hypogonadism 23 without anosmia 11.0
17 laugier-hunziker syndrome 10.9
18 adrenal hypoplasia, congenital, with absent pituitary luteinizing hormone 10.9
19 progesterone resistance 10.9
20 pituitary hormone deficiency, combined, 1 10.9
21 ovarian dysgenesis 1 10.9
22 crandall syndrome 10.9
23 diabetes insipidus 10.3
24 polycystic ovary syndrome 10.2
25 prostatitis 10.2
26 autoimmune retinopathy 10.2 ENO1 ENO2
27 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
28 precocious puberty 10.2
29 adenoma 10.2
30 cancer-associated retinopathy 10.1 ENO1 ENO2
31 hypogonadism 10.1
32 anovulation 10.1
33 brain injury 10.1 ENO1 ENO2
34 hypothalamic disease 10.1 GH1 POMC
35 diabetes insipidus, neurohypophyseal 10.1
36 thyroiditis 10.1
37 empty sella syndrome 10.1 GH1 POMC
38 hypoadrenalism 10.1 GH1 POMC
39 hyperpituitarism 10.0 GH1 POMC
40 hypothyroidism, congenital, nongoitrous, 4 10.0 GH1 POMC
41 acute thyroiditis 10.0 ENO2 POMC
42 chromophobe adenoma 10.0 GH1 POMC
43 cervix small cell carcinoma 10.0 ENO2 POMC
44 cloacogenic carcinoma 10.0 ENO2 POMC
45 pituitary gland disease 10.0 GH1 POMC
46 gonadal disease 9.9 GH1 POMC
47 organ system benign neoplasm 9.9 ENO2 POMC
48 pituitary adenoma, prolactin-secreting 9.9 GH1 POMC
49 pituitary apoplexy 9.9
50 aging 9.9

Graphical network of the top 20 diseases related to Lymphocytic Hypophysitis:



Diseases related to Lymphocytic Hypophysitis

Symptoms & Phenotypes for Lymphocytic Hypophysitis

Drugs & Therapeutics for Lymphocytic Hypophysitis

Search Clinical Trials , NIH Clinical Center for Lymphocytic Hypophysitis

Genetic Tests for Lymphocytic Hypophysitis

Anatomical Context for Lymphocytic Hypophysitis

MalaCards organs/tissues related to Lymphocytic Hypophysitis:

38
Pituitary, Thyroid, Eye, Hypothalamus

Publications for Lymphocytic Hypophysitis

Articles related to Lymphocytic Hypophysitis:

(show top 50) (show all 192)
# Title Authors Year
1
Mycophenolate mofetil treatment in a patient with recurrent lymphocytic hypophysitis. ( 29306856 )
2018
2
Occurrence of primary lymphocytic hypophysitis in two horses and presence of scattered T-lymphocytes in the normal equine pituitary gland. ( 27852816 )
2017
3
Lymphocytic Hypophysitis Successfully Treated with Stereotactic Radiosurgery: Case Report and Review of the Literature. ( 28743133 )
2017
4
Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18A years. ( 28423475 )
2017
5
Lymphocytic Hypophysitis Mimicking Pituitary Macroadenoma. ( 28527171 )
2017
6
VARIATIONS IN CLINICAL AND IMAGING FINDINGS BY TIME OF DIAGNOSIS IN FEMALES WITH HYPOPITUITARISM ATTRIBUTED TO LYMPHOCYTIC HYPOPHYSITIS. ( 26595515 )
2016
7
Management of lymphocytic hypophysitis. ( 26963662 )
2016
8
A primer on pituitary injury for the obstetrician gynecologist: Simmonds disease, Sheehan's syndrome, Traumatic injury, Dahan' s syndrome, Pituitary Apoplexy and Lymphocytic Hypophysitis. ( 27405776 )
2016
9
Granulomatous and lymphocytic hypophysitis - are they immunologically distinct? ( 27704605 )
2016
10
Lymphocytic hypophysitis: An unusual etiology of a usual presentation. ( 27728188 )
2016
11
A study of primary hypophysitis, i.e., two cases of lymphocytic hypophysitis and one IgG4-related variant: The importance of measuring serum IgG4 levels to allow early diagnosis and prompt treatment for the IgG4-related variant. ( 27375049 )
2016
12
Lymphocytic hypophysitis in nonpregnant middle-aged females mimicking pituitary adenoma. ( 26732199 )
2016
13
Lymphocytic hypophysitis: modern day management with limited role for surgery. ( 27778295 )
2016
14
Cerebral Vasospasm Following Transsphenoidal Hypophysectomy in the Treatment of Lymphocytic Hypophysitis. ( 27244208 )
2016
15
Clinical profile of lymphocytic hypophysitis. ( 27728211 )
2016
16
Clinical course of IgG4-related hypophysitis presenting with focal seizure and relapsing lymphocytic hypophysitis. ( 26510826 )
2015
17
HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis. ( 26317559 )
2015
18
Lymphocytic hypophysitis in the elderly. ( 26094558 )
2015
19
LYMPHOCYTIC HYPOPHYSITIS: A RARE AUTOIMMUNE DISORDER PRESENT IN A LARGE SUPRA SELLAR MASS HAVING COMPLETE RESOLUTION WITH STEROIDS. ( 26411146 )
2015
20
A Protracted and Aggressive Variant of Lymphocytic Hypophysitis with Mammillary Body Involvement and Cognitive Dysfunction. ( 25100390 )
2014
21
Lymphocytic hypophysitis associated with pediatric multiple sclerosis. ( 25266625 )
2014
22
Lymphocytic hypophysitis in non-pregnant middle-aged females mimicking pituitary adenoma: A report of two cases. ( 25370565 )
2014
23
Autoimmune lymphocytic hypophysitis in association with autoimmune eye disease and sequential treatment with infliximab and rituximab. ( 25224140 )
2014
24
Hypopituitarism possibly due to lymphocytic hypophysitis in a patient with type 1 diabetes. ( 25175130 )
2014
25
Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis. ( 23329361 )
2013
26
A case of apoplectic lymphocytic hypophysitis complicated by polymyalgia rheumatica. ( 20514486 )
2013
27
An intrasellar germinoma with normal tumor marker concentrations mimicking primary lymphocytic hypophysitis. ( 24232824 )
2013
28
Lymphocytic hypophysitis in males. ( 23485405 )
2013
29
Isolated adrenocorticotropic hormone deficiency due to probable lymphocytic hypophysitis in a woman. ( 24251125 )
2013
30
Comment on "Lymphocytic hypophysitis with proACTH". ( 23138353 )
2012
31
Reversible impairment of the processing of proopiomelanocortin into ACTH in pituitary enlargement suspected of lymphocytic hypophysitis. ( 23064477 )
2012
32
Lymphocytic hypophysitis masquerading as pituitary adenoma. ( 23565408 )
2012
33
Bilateral intracavernous carotid artery occlusion caused by invasive lymphocytic hypophysitis. ( 22749630 )
2012
34
Combined granulomatous and lymphocytic hypophysitis presenting as pituitary incidentaloma in a middle-aged woman. ( 23087881 )
2012
35
Recurrent anaphylactic reactions: an uncommon debut of lymphocytic hypophysitis. ( 22573101 )
2012
36
Lymphocytic hypophysitis in a dog with diabetes insipidus. ( 22789859 )
2012
37
Lymphocytic hypophysitis in a patient presenting with sequential episodes of optic neuritis. ( 20676777 )
2012
38
Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab. ( 22443503 )
2012
39
Identification of TPIT and other novel autoantigens in lymphocytic hypophysitis: immunoscreening of a pituitary cDNA library and development of immunoprecipitation assays. ( 22193973 )
2012
40
Lymphocytic hypophysitis accompanied by aseptic meningitis mimics subacute meningoencephalitis. ( 21921390 )
2011
41
Painful oculomotor nerve palsy due to lymphocytic hypophysitis. ( 21205701 )
2011
42
Lymphocytic hypophysitis: an underestimated disease affecting the sellar region. ( 21574123 )
2011
43
The coexistence of an intrasellar adenoma, lymphocytic hypophysitis, and primary pituitary lymphoma in a patient with acromegaly. ( 22937293 )
2011
44
Lymphocytic hypophysitis in children: a novel presentation and literature review. ( 21212455 )
2011
45
Spontaneous pregnancy in a patient with a relapse of lymphocytic hypophysitis successfully treated with azathioprine and glucocorticoids. ( 21442379 )
2011
46
Parasellar T2 dark sign on MR imaging in patients with lymphocytic hypophysitis. ( 20651017 )
2010
47
Lymphocytic hypophysitis: differential diagnosis and effects of high-dose pulse steroids, followed by azathioprine, on the pituitary mass and endocrine abnormalities--report of a case and literature review. ( 20098956 )
2010
48
Suprasellar germinoma masquerading as lymphocytic hypophysitis associated with central diabetes insipidus, delayed sexual development, and subsequent hypopituitarism. ( 20051818 )
2010
49
Unusual magnetic resonance imaging finding in a male with lymphocytic hypophysitis mimicking a pituitary tumor. ( 19498319 )
2010
50
Lymphocytic hypophysitis with a long latent period from onset of central diabetes insipidus to development of pituitary enlargement. ( 20686292 )
2010

Variations for Lymphocytic Hypophysitis

Expression for Lymphocytic Hypophysitis

Search GEO for disease gene expression data for Lymphocytic Hypophysitis.

Pathways for Lymphocytic Hypophysitis

GO Terms for Lymphocytic Hypophysitis

Cellular components related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ENO1 ENO2 ENO3 GH1 POMC
2 phosphopyruvate hydratase complex GO:0000015 8.8 ENO1 ENO2 ENO3

Biological processes related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gluconeogenesis GO:0006094 9.33 ENO1 ENO2 ENO3
2 glycolytic process GO:0006096 9.13 ENO1 ENO2 ENO3
3 canonical glycolysis GO:0061621 8.8 ENO1 ENO2 ENO3

Molecular functions related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.33 ENO1 ENO2 ENO3
2 hormone activity GO:0005179 9.26 GH1 POMC
3 lyase activity GO:0016829 9.13 ENO1 ENO2 ENO3
4 phosphopyruvate hydratase activity GO:0004634 8.8 ENO1 ENO2 ENO3

Sources for Lymphocytic Hypophysitis

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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36 KEGG
37 LifeMap
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41 MeSH
42 MESH via Orphanet
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47 NDF-RT
50 NINDS
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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