MCID: LYM043
MIFTS: 30

Lymphocytic Hypophysitis

Categories: Rare diseases, Immune diseases

Aliases & Classifications for Lymphocytic Hypophysitis

MalaCards integrated aliases for Lymphocytic Hypophysitis:

Name: Lymphocytic Hypophysitis 50
Autoimmune Hypophysitis 50 69
Lymphocytic Hypopituitarism 69
Lyh 50
Lh 50

Classifications:



Summaries for Lymphocytic Hypophysitis

NIH Rare Diseases : 50 lymphocytic hypophysitis (lh) is a condition in which the pituitary gland becomes infiltrated by lymphocytes, resulting in pituitary enlargement and impaired function. it most often occurs in women in late pregnancy or the postpartum period, but can also occur in prepubertal or post-menopausal women, and in men. symptoms of lh may include headache, visual field impairment and more rarely, double vision (diplopia). the exact cause is unknown but is thought to be autoimmune-related. although some cases resolve on their own or after a short course of steroids, other cases cause persistent problems even with aggressive medical or surgical treatment. last updated: 10/1/2012

MalaCards based summary : Lymphocytic Hypophysitis, also known as autoimmune hypophysitis, is related to leydig cell hypoplasia and resistance to lh. An important gene associated with Lymphocytic Hypophysitis is ENO1 (Enolase 1), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Glucose metabolism. Affiliated tissues include pituitary, thyroid and eye.

Wikipedia : 72 Autoimmune hypophysitis or Lymphocytic hypophysitis is defined as inflammation of the pituitary gland... more...

Related Diseases for Lymphocytic Hypophysitis

Diseases related to Lymphocytic Hypophysitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
id Related Disease Score Top Affiliating Genes
1 leydig cell hypoplasia 11.8
2 resistance to lh 11.8
3 male pseudohermaphroditism due to defective lh molecule 11.8
4 leydig cell hypoplasia with pseudohermaphroditism 11.8
5 hypogonadotropic hypogonadism 11.1
6 hypogonadotropic hypogonadism 23 with or without anosmia 10.9
7 acth-independent macronodular adrenal hyperplasia 10.9
8 adrenal hypoplasia, congenital, with absent pituitary luteinizing hormone 10.8
9 laugier-hunziker syndrome 10.8
10 ovarian dysgenesis 1 10.7
11 pituitary hormone deficiency, combined, 1 10.7
12 progesterone resistance 10.7
13 crandall syndrome 10.7
14 autosomal dominant compelling helio ophthalmic outburst syndrome 10.3 ENO1 ENO2
15 acitretin/etretinate embryopathy 10.3 ENO1 ENO2
16 brain meningioma 10.2 ENO1 ENO2
17 diabetes insipidus 10.2
18 aortic valve atresia 10.2 GH1 POMC
19 intermittent squint 10.2 GH1 POMC
20 lactic acidosis 10.1 GH1 POMC
21 hypodermyasis 10.1 GH1 POMC
22 protein s deficiency 10.1 GH1 POMC
23 hypopituitarism 10.1
24 polycystic ovary syndrome 10.1
25 hypothyroidism, congenital, nongoitrous 4 10.1 GH1 POMC
26 strabismus 10.1 GH1 POMC
27 prostatitis 10.1
28 precocious puberty 10.1
29 parietal lobe neoplasm 10.1 ENO2 POMC
30 diencephalic neoplasm 10.1 GH1 POMC
31 adenoma 10.1
32 psychogenic movement 10.1 GH1 POMC
33 hypogonadism 10.1
34 anovulation 10.1
35 molybdenum cofactor deficiency b 10.0 GH1 POMC
36 internal auditory canal lipoma 10.0 ENO2 POMC
37 anal canal squamous cell carcinoma 10.0 ENO2 POMC
38 adrenal cortex disease 10.0 GH1 POMC
39 peritoneal benign neoplasm 10.0 ENO2 POMC
40 pituitary adenoma 10.0
41 central precocious puberty 10.0
42 uterine ligament clear cell adenocarcinoma 10.0 GH1 POMC
43 prostate cancer 10.0
44 thyroiditis 10.0
45 capillary lymphangioma 10.0 GH1 POMC
46 ovarian disease 10.0
47 infertility 10.0
48 vestibular gland benign neoplasm 10.0 ENO2 POMC
49 alpha-methylacyl-coa racemase deficiency 9.9 GH1 POMC
50 pituitary adenoma, acth-secreting 9.9 GH1 POMC

Graphical network of the top 20 diseases related to Lymphocytic Hypophysitis:



Diseases related to Lymphocytic Hypophysitis

Symptoms & Phenotypes for Lymphocytic Hypophysitis

Drugs & Therapeutics for Lymphocytic Hypophysitis

Search Clinical Trials , NIH Clinical Center for Lymphocytic Hypophysitis

Genetic Tests for Lymphocytic Hypophysitis

Anatomical Context for Lymphocytic Hypophysitis

MalaCards organs/tissues related to Lymphocytic Hypophysitis:

39
Pituitary, Thyroid, Eye, Hypothalamus

Publications for Lymphocytic Hypophysitis

Articles related to Lymphocytic Hypophysitis:

(show top 50) (show all 191)
id Title Authors Year
1
Lymphocytic Hypophysitis Mimicking Pituitary Macroadenoma. ( 28527171 )
2017
2
Primary lymphocytic hypophysitis: Clinical characteristics and treatment of 50 cases in a single centre in China over 18A years. ( 28423475 )
2017
3
Lymphocytic Hypophysitis Successfully Treated with Stereotactic Radiosurgery: Case Report and Review of the Literature. ( 28743133 )
2017
4
Occurrence of primary lymphocytic hypophysitis in two horses and presence of scattered T-lymphocytes in the normal equine pituitary gland. ( 27852816 )
2017
5
Lymphocytic hypophysitis: modern day management with limited role for surgery. ( 27778295 )
2016
6
Cerebral Vasospasm Following Transsphenoidal Hypophysectomy in the Treatment of Lymphocytic Hypophysitis. ( 27244208 )
2016
7
Granulomatous and lymphocytic hypophysitis - are they immunologically distinct? ( 27704605 )
2016
8
Clinical profile of lymphocytic hypophysitis. ( 27728211 )
2016
9
Lymphocytic hypophysitis in nonpregnant middle-aged females mimicking pituitary adenoma. ( 26732199 )
2016
10
Management of lymphocytic hypophysitis. ( 26963662 )
2016
11
A study of primary hypophysitis, i.e., two cases of lymphocytic hypophysitis and one IgG4-related variant: The importance of measuring serum IgG4 levels to allow early diagnosis and prompt treatment for the IgG4-related variant. ( 27375049 )
2016
12
Lymphocytic hypophysitis: An unusual etiology of a usual presentation. ( 27728188 )
2016
13
VARIATIONS IN CLINICAL AND IMAGING FINDINGS BY TIME OF DIAGNOSIS IN FEMALES WITH HYPOPITUITARISM ATTRIBUTED TO LYMPHOCYTIC HYPOPHYSITIS. ( 26595515 )
2016
14
A primer on pituitary injury for the obstetrician gynecologist: Simmonds disease, Sheehan's syndrome, Traumatic injury, Dahan' s syndrome, Pituitary Apoplexy and Lymphocytic Hypophysitis. ( 27405776 )
2016
15
LYMPHOCYTIC HYPOPHYSITIS: A RARE AUTOIMMUNE DISORDER PRESENT IN A LARGE SUPRA SELLAR MASS HAVING COMPLETE RESOLUTION WITH STEROIDS. ( 26411146 )
2015
16
Clinical course of IgG4-related hypophysitis presenting with focal seizure and relapsing lymphocytic hypophysitis. ( 26510826 )
2015
17
HLA Markers DQ8 and DR53 Are Associated With Lymphocytic Hypophysitis and May Aid in Differential Diagnosis. ( 26317559 )
2015
18
Lymphocytic hypophysitis in the elderly. ( 26094558 )
2015
19
Autoimmune lymphocytic hypophysitis in association with autoimmune eye disease and sequential treatment with infliximab and rituximab. ( 25224140 )
2014
20
A Protracted and Aggressive Variant of Lymphocytic Hypophysitis with Mammillary Body Involvement and Cognitive Dysfunction. ( 25100390 )
2014
21
Hypopituitarism possibly due to lymphocytic hypophysitis in a patient with type 1 diabetes. ( 25175130 )
2014
22
Lymphocytic hypophysitis in non-pregnant middle-aged females mimicking pituitary adenoma: A report of two cases. ( 25370565 )
2014
23
Lymphocytic hypophysitis associated with pediatric multiple sclerosis. ( 25266625 )
2014
24
Isolated adrenocorticotropic hormone deficiency due to probable lymphocytic hypophysitis in a woman. ( 24251125 )
2013
25
An intrasellar germinoma with normal tumor marker concentrations mimicking primary lymphocytic hypophysitis. ( 24232824 )
2013
26
A case of apoplectic lymphocytic hypophysitis complicated by polymyalgia rheumatica. ( 20514486 )
2013
27
Intermediate lobe immunoreactivity in a patient with suspected lymphocytic hypophysitis. ( 23329361 )
2013
28
Lymphocytic hypophysitis in males. ( 23485405 )
2013
29
Identification of TPIT and other novel autoantigens in lymphocytic hypophysitis: immunoscreening of a pituitary cDNA library and development of immunoprecipitation assays. ( 22193973 )
2012
30
Combined granulomatous and lymphocytic hypophysitis presenting as pituitary incidentaloma in a middle-aged woman. ( 23087881 )
2012
31
Bilateral intracavernous carotid artery occlusion caused by invasive lymphocytic hypophysitis. ( 22749630 )
2012
32
Lymphocytic hypophysitis in a patient presenting with sequential episodes of optic neuritis. ( 20676777 )
2012
33
Lymphocytic hypophysitis in a dog with diabetes insipidus. ( 22789859 )
2012
34
Comment on "Lymphocytic hypophysitis with proACTH". ( 23138353 )
2012
35
Lymphocytic hypophysitis masquerading as pituitary adenoma. ( 23565408 )
2012
36
Reversible impairment of the processing of proopiomelanocortin into ACTH in pituitary enlargement suspected of lymphocytic hypophysitis. ( 23064477 )
2012
37
Recurrent anaphylactic reactions: an uncommon debut of lymphocytic hypophysitis. ( 22573101 )
2012
38
Novel strategy to treat a case of recurrent lymphocytic hypophysitis using rituximab. ( 22443503 )
2012
39
Lymphocytic hypophysitis in children: a novel presentation and literature review. ( 21212455 )
2011
40
Lymphocytic hypophysitis accompanied by aseptic meningitis mimics subacute meningoencephalitis. ( 21921390 )
2011
41
Spontaneous pregnancy in a patient with a relapse of lymphocytic hypophysitis successfully treated with azathioprine and glucocorticoids. ( 21442379 )
2011
42
Painful oculomotor nerve palsy due to lymphocytic hypophysitis. ( 21205701 )
2011
43
The coexistence of an intrasellar adenoma, lymphocytic hypophysitis, and primary pituitary lymphoma in a patient with acromegaly. ( 22937293 )
2011
44
Lymphocytic hypophysitis: an underestimated disease affecting the sellar region. ( 21574123 )
2011
45
Lymphocytic hypophysitis with a long latent period from onset of central diabetes insipidus to development of pituitary enlargement. ( 20686292 )
2010
46
Lymphocytic hypophysitis with normal pituitary function mimicking a pituitary adenoma: a case report and review of literature. ( 20040330 )
2010
47
Suprasellar germinoma masquerading as lymphocytic hypophysitis associated with central diabetes insipidus, delayed sexual development, and subsequent hypopituitarism. ( 20051818 )
2010
48
Unusual magnetic resonance imaging finding in a male with lymphocytic hypophysitis mimicking a pituitary tumor. ( 19498319 )
2010
49
Gamma knife surgery for lymphocytic hypophysitis. ( 19558303 )
2010
50
Lymphocytic hypophysitis with diabetes insipidus in a young man. ( 20585348 )
2010

Variations for Lymphocytic Hypophysitis

Expression for Lymphocytic Hypophysitis

Search GEO for disease gene expression data for Lymphocytic Hypophysitis.

Pathways for Lymphocytic Hypophysitis

GO Terms for Lymphocytic Hypophysitis

Cellular components related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.35 ENO1 ENO2 ENO3 GH1 POMC
2 phosphopyruvate hydratase complex GO:0000015 8.8 ENO1 ENO2 ENO3

Biological processes related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 gluconeogenesis GO:0006094 9.33 ENO1 ENO2 ENO3
2 glycolytic process GO:0006096 9.13 ENO1 ENO2 ENO3
3 canonical glycolysis GO:0061621 8.8 ENO1 ENO2 ENO3

Molecular functions related to Lymphocytic Hypophysitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.33 ENO1 ENO2 ENO3
2 hormone activity GO:0005179 9.26 GH1 POMC
3 lyase activity GO:0016829 9.13 ENO1 ENO2 ENO3
4 phosphopyruvate hydratase activity GO:0004634 8.8 ENO1 ENO2 ENO3

Sources for Lymphocytic Hypophysitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....