Lymphocytic Leukemia malady

Wikipedia: Lymphoid leukemia or lymphocytic leukemia is a type of leukemia affecting circulating lymphocyte cells....⁴⁴ more...

MalaCards: Lymphocytic Leukemia, also known as lymphoid leukemia, is related to leukemia and carcinoma. An important gene associated with Lymphocytic Leukemia is MME (membrane metallo-endopeptidase), and among its related pathways are MIF Regulation of Innate Immune Cells and MIF Mediated Glucocorticoid Regulation. The drug teniposide and the compounds nitric oxide and estradiol have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and lung, and related mouse phenotypes are skeleton and immune system.

lymphocytic leukemia 7 lymphoid leukemia 43

Diseases related to lymphocytic leukemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 803)

id	Related Disease	Score	Top Affiliating Genes
1	leukemia	193.8	PIK3CD, PIM2, PIK3CA, PIK3CG, PIGU, RFX7
2	carcinoma	132.2	ZNF382, PIK3CD, PIM2, PIK3CA, PIK3CG, PIGU
3	prostatitis	106.9	PIK3CD, PIM2, PIK3CA, PIK3CG, NCAM1, NCL
4	arthritis	90.4	PIK3CD, PIK3CG, PDCD1LG2, PDE4A, RECK, REL
5	myeloma	90.3	PIM2, PIK3CA, PIK3CG, NCAM1, PDE4A, RECK
6	myeloid leukemia	89.7	PIK3CD, PIM2, PIK3CA, PIK3CG, NCAM1, NCL
7	non-hodgkin lymphoma	85.3	PIM2, PIK3CA, REL, RELB, KIR2DL1, KIR2DL3
8	lymphoblastic leukemia	82.5	PIK3CA, PIK3CG, NCAM1, RECK, RELA, KIT
9	lupus erythematosus	74.9	PIK3CD, PIK3CG, NCL, PDCD1LG2, RECK, REL
10	acute myeloid leukemia	74.2	PIK3CD, PIM2, PIK3CA, PIK3CG, NCAM1, NCL
11	chronic lymphocytic leukemia	72.1	PDE3B, PDE4A, REL, SELL, BRCA2, LPL
12	acute leukemia	65.2	PIK3CA, NCAM1, NCL, KIT, KITLG, RB1
13	anemia	62.5	NCAM1, RELA, REV1, KIT, KITLG, RB1
14	diffuse large b-cell lymphoma	62.1	PIK3CA, PIK3CG, NCAM1, PDE4A, PDE4B, REL
15	lung carcinoma	61.1	PIK3CA, PIK3CG, NCAM1, RECK, BUB1B, GCNT1
16	acute lymphocytic leukemia	60.5	ZNF382, WASF1, RB1, SERPINC1, VEGFA, VEGFC
17	mantle cell lymphoma	59.3	PIM2, PIK3CA, PIK3CG, KIT, SFRP1, RB1
18	acute lymphoblastic leukemia	57.3	RECK, KIT, KITLG, KIR3DL1, BTK, RB1
19	neuronitis	57.1	PIK3CD, PIK3CA, PIK3CG, NCAM1, NCL, PDE3B
20	pancreatitis	56.6	PIK3CD, PIK3CA, PIK3CG, NCAM1, NCL, PDCD1LG2
21	myelodysplastic syndrome	56.2	PIK3CG, NCAM1, NCL, PDE4A, KIT, KITLG
22	melanoma	55.8	PIK3CD, PIK3CA, PIK3CG, PIGU, NCAM1, NCL
23	leukemia/lymphoma	54.8	PIM2, PIK3CA, PIK3CG, PDCD1LG2, REL, CNTN2
24	retinoblastoma	54.7	PIK3CD, PIK3CA, PIK3CG, NCAM1, NCL, PDE3B
25	b-cell lymphomas	53.8	REL, BTK, RB1, NBN, MYC, MYCN
26	adenocarcinoma	53.4	PIM2, PIK3CA, PIK3CG, NCAM1, NCL, RECK
27	myocardial infarction	51.1	PIK3CG, PDE4A, RECK, KITLG, RCAN1, SELL
28	t-cell leukemia	50.8	PIK3CG, REL, RELA, CNTN2, MYC, MYB
29	hepatocellular carcinoma	50.7	PIK3CD, PIM2, PIK3CA, PIK3CG, NCAM1, NCL
30	hodgkin's lymphoma	50.2	PIK3CG, REL, SELP, BRCA2, RAG1, BLZF1
31	gastric cancer	49.0	PIK3CA, PIK3CG, NCL, RECK, RELA, REV3L
32	immunodeficiency	48.3	PIK3CD, KIR3DL1, BTK, SELL, MYD88, BMP6
33	burkitt's lymphoma	47.5	MYC, MYCN, MYB, MYBL1, BMP6, RAG1
34	systemic lupus erythematosus	47.5	NCL, RECK, NAT2, VCAM1, BLZF1, BCR
35	ataxia	46.8	PIM2, PIK3CA, PIK3CG, SGCE, BYSL, NBN
36	chronic myeloid leukemia	46.6	PIK3CG, KIT, KITLG, KIR3DL1, SELP, MYC
37	sjogren's syndrome	46.3	KIR2DL1, KIR2DL3, KITLG, KIR3DL1, SELL, VCAM1
38	thyroiditis	45.6	PIK3CA, PIK3CG, NCAM1, PDE4A, RECK, RELA
39	gonococcal synovitis	45.4	PIK3CA, PIK3CG, NCAM1, PDE3B, PDE4A, RECK
40	cervicitis	44.9	PIK3CA, PIK3CG, NCL, PDCD1LG2, PDE4A, RECK
41	b-cell non-hodgkin lymphoma	44.9	RB1, VEGFA, MYC, BIRC5, PAX5, BCL10
42	large granular lymphocyte leukemia	44.8	PIK3CG, CNTN2, KIR2DL1, KIR2DL3, BCL2, BCL2L1
43	renal cell carcinoma	44.4	PIK3CA, RELA, KIT, SFRP1, SELP, VIM
44	colon cancer	43.6	PIK3CA, PIK3CG, NCAM1, PDE4A, RECK, RELA
45	esophagitis	43.5	PIK3CA, PIK3CG, NCAM1, PDCD1LG2, PDE4A, RECK
46	neutropenia	43.3	KITLG, BTK, BLZF1, BIRC5, BCL2, LEF1
47	severe combined immunodeficiency	43.2	KITLG, SELP, VHL, VEGFA, MYC, RAG1
48	combined immunodeficiency	42.8	KITLG, NBN, SELP, VHL, VEGFA, MYC
49	sarcoma	42.8	PIK3CD, PIK3CA, PIK3CG, NCAM1, PDE4A, RECK
50	vasculitis	42.5	SELL, SELP, SELPLG, SERPINC1, VEGFA, VEGFC

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 teniposide

MalaCards organs/tissues related to lymphocytic leukemia:

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MGI Mouse Phenotypes related to lymphocytic leukemia:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	INF	PIK3CD, PIK3CG, RECK, REL, RELA, KIT
2	immune system phenotype	MP:0005387	INF	PIK3CD, PIM2, NCKAP1L, PDE4A, PDE4B, REL
3	integument phenotype	MP:0010771	INF	PIK3CG, PDE3B, RECK, REL, RELA, RELB
4	cellular phenotype	MP:0005384	INF	PIK3CD, PIM2, PIK3CA, PIK3CG, NCAM1, NCKAP1L
5	behavior/neurological phenotype	MP:0005386	27.3	PIK3CA, NCAM1, RELB, SGCE, CNTN2, WASF1
6	reproductive system phenotype	MP:0005389	26.8	PIK3CA, NCKAP1L, SFN, SFRP2, SFRP4, SFRP5
7	limbs/digits/tail phenotype	MP:0005371	21.5	RECK, RELA, RELB, KIT, KITLG, SFN
8	renal/urinary system phenotype	MP:0005367	21.4	NCKAP1L, KIT, SFRP4, GCNT1, SELP, SELPLG
9	hearing/vestibular/ear phenotype	MP:0005377	16.3	KIT, KITLG, SFN, RB1, MYC, MYD88
10	other phenotype	MP:0005395	14.6	NCKAP1L, RECK, RELB, PBX1, KDR, LAMA5
11	pigmentation phenotype	MP:0001186	13.4	PDE3B, KIT, KITLG, RB1, SERPINC1, BRAF
12	mortality/aging	MP:0010768	INF	PIK3CA, NCAM1, PDCD1LG2, PDE4B, RECK, REL
13	adipose tissue phenotype	MP:0005375	INF	PIK3CA, PDE3B, SFRP1, BUB1B, RB1, BRAF
14	digestive/alimentary phenotype	MP:0005381	INF	REL, RELB, WASF1, KIT, KITLG, SFN
15	vision/eye phenotype	MP:0005391	INF	PIK3CA, NCAM1, RELA, KIT, KITLG, SFN
16	liver/biliary system phenotype	MP:0005370	INF	NCKAP1L, RECK, REL, RELB, WASF1, KIT
17	growth/size phenotype	MP:0005378	INF	PIM2, PIK3CA, PIK3CG, NCKAP1L, PDE3B, RECK
18	normal phenotype	MP:0002873	INF	RELA, REV1, SFRP2, SFRP5, GCNT1, RBL2
19	endocrine/exocrine gland phenotype	MP:0005379	INF	RELB, SFN, SFRP2, SFRP5, RCAN1, RBL2
20	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CD, PIK3CA, PIK3CG, NCKAP1L, PDCD1LG2, PDE3B
21	tumorigenesis	MP:0002006	INF	PIK3CA, PDCD1LG2, REV3L, KIT, KITLG, SFN
22	nervous system phenotype	MP:0003631	INF	PDE4A, PDE4B, RECK, REL, RELA, REV3L
23	hematopoietic system phenotype	MP:0005397	INF	PIM2, NCKAP1L, PDCD1LG2, REV1, REV3L, KIT
24	craniofacial phenotype	MP:0005382	INF	REV3L, KIT, KITLG, NBN, BRWD3, LPAR1
25	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3CG, RELA, RELB, SGCE, WASF1
26	respiratory system phenotype	MP:0005388	INF	NCKAP1L, REL, RELB, SFRP4, SELL, SELP
27	cardiovascular system phenotype	MP:0005385	INF	PIK3CD, PIK3CA, PIK3CG, NCKAP1L, PDE4A, PDE4B
28	embryogenesis phenotype	MP:0005380	INF	PIK3CA, RECK, REL, REV3L, KIT, SFN
29	no phenotypic analysis	MP:0003012	INF	PIK3CD, PDCD1LG2, SFRP1, SFRP2, RB1, RBL2

Articles related to lymphocytic leukemia:

(show top 50)    (show all 1275)

id	Title	Authors	Year	Affiliating Genes
1	Polymorphisms and haplotypes in multidrug resistance 1 gene are not associated with chronic lymphocytic leukemia susceptibility and prognostic parameters of chronic lymphocytic leukemia in Chinese population. (21463115)	Dong H.J.... Li J.Y.	2011	ZAP70, TP53, ABCB1
2	ROS-mediated upregulation of Noxa overcomes chemoresi stance in chronic lymphocytic leukemia. (20935673)	Tonino S.H.... Kater A.P.	2011	PMAIP1
3	MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia. (21296997)	Vargova K.... Stopka T.	2011	MYB, MIR155HG, MIR155
4	Many chronic lymphocytic leukemia antibodies recogniz e apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications f or patient outcome and cell of origin. (20110421)	Chu C.C.... Chiorazzi N.	2010	MYH9
5	Stereotyped B-cell receptor is an independent risk fa ctor of chronic lymphocytic leukemia transformation to Richter syndrome. (19509140)	Rossi D.... Gaidano G.	2009	BCR
6	microRNA-29c and microRNA-223 down-regulation has in vivo significance in chronic lymphocytic leukemia and improves disease risk str atification. (19144983)	Stamatopoulos B.... Lagneaux L.	2009	MIR223, MIR29C
7	Subcutaneous alemtuzumab in fludarabine-refractory ch ronic lymphocytic leukemia: clinical results and prognostic marker analyses fro m the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. (19597025)	Stilgenbauer S.... DAPhner H.	2009	TP53, TKT
8	Evidence of serum immunoglobulin abnormalities up to 9.8 years before diagnosis of chronic lymphocytic leukemia: a prospective study . (19828698)	Tsai H.T.... Landgren O.	2009	MYOM2
9	PKCbeta is essential for the development of chronic lymphocytic leukemia in the TCL1 transgenic mouse model: validation of PKCbeta as a therapeutic target in chronic lymphocytic leukemia. (19168795)	Holler C.... Egle A.	2009	BCR, PRKCB, TCL1A
10	Detection of human cyclin C gene expression in childhood acute lymphocytic leukemia using real-time fluorescence quantitative PCR (18289462)	Zhang Z.X.... Yu Y.	2008	CCNC
11	Modulation of IL-4 level by fludarabine and its relat ion to apoptosis in chronic B-cell lymphocytic leukemia. (20306682)	Shamaa L.A.... Ali M.A.	2008	IL4
12	The Aiolos transcription factor is up-regulated in chronic lymphocytic leukemia. (18184862)	Duhamel M.... Rebollo A.	2008	IKZF1, IKZF3
13	Cell motility in chronic lymphocytic leukemia: defective Rap1 and alphaLbeta2 activation by chemokine. (18922916)	Till K.J.... Cawley J.C.	2008	ITGB2, ITGAL, TERF2IP
14	Modulation of the human equilibrative nucleoside transporter1 (hENT1) activity by IL-4 and PMA in B cells from chronic lymphocytic leukemia. (18078872)	FernA!ndez Calotti P.... Giordano M.	2008	IL4
15	Immunophenotypic features distinguishing familial chronic lymphocytic leukemia from sporadic chronic lymphocytic leukemia. (18431797)	Ahmad E.... Stetler-Stevenson M.	2008	ANPEP, CD2, CD38
16	17p Deletion is associated with resistance of B-cell chronic lymphocytic leukemia cells to in vitro fludarabine-induced apoptosis. (17325891)	Turgut B.... AlgA1neA9 C.	2007	TP53
17	ZAP-70 enhances B-cell-receptor signaling despite absent or inefficient tyrosine kinase activation in chronic lymphocytic leukemia and lymphoma B cells. (17038529)	Gobessi S.... Efremov D.G.	2007	ZAP70, SYK
18	CD39 activity correlates with stage and inhibits platelet reactivity in chronic lymphocytic leukemia. (17480228)	Pulte D.... Marcus A.J.	2007	ENTPD1
19	The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells. (16699949)	Kabore A.F.... Gibson S.B.	2006	TNFRSF10B, TNFSF10, TNFRSF10A
20	A robust ratio metric method for analysis of Zap-70 expression in chronic lymphocytic leukemia (CLL). (16342060)	Bakke A.C.... Huang J.	2006	ZAP70
21	Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia. (16203783)	Biagi E.... Brenner M.	2005	IL2
22	HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia. (15466928)	Nuckel H.... Grosse-Wilde H.	2005	HLA-G
23	Filgrastim and alemtuzumab (Campath-1H) for refractor y chronic lymphocytic leukemia. (15858611)	Lin T.S.... Byrd J.C.	2005	CSF3
24	Fc gamma RIIIa and Fc gamma RIIa polymorphisms do not predict response to rituximab in B-cell chronic lymphocytic leukemia. (14563637)	Farag S.S.... Byrd J.C.	2004	FCGR3A, FCGR2A
25	Expression of adhesion molecules on leukemic B cells from chronic lymphocytic leukemia patients with predominantly splenic manifestations. (15055269)	Bairey O.... Shaklai M.	2004	ITGAX
26	CXCR4 but not CXCR3 expression correlates with lymphocyte counts in B-cell chronic lymphocytic leukemia. (14986066)	Dao-Ung L.P.... Wiley J.S.	2004	CXCR4, CXCR3
27	ATM mutations in B-cell chronic lymphocytic leukemia. (14754616)	Lahdesmaki A.... Hammarstrom L.	2004	ATM
28	Differential expression of survivin in bone marrow cells from patients with acute lymphocytic leukemia and chronic lymphocytic leukemia. (15068902)	Nakagawa Y.... Kitagawa M.	2004	BIRC5
29	Some genomic aberrations in B-cell chronic lymphocytic leukemia and their clinical relevance. Part I. B-cell lymphocytic leukemia with TP53 gene deletion (15052934)	Koczkodaj D.... Bojarska-Junak A.	2003	TP53
30	Some genomic aberrations in B-cell chronic lymphocytic leukemia and their clinical relevance. Part II. Trisomy 12 in B-cell chronic lymphocytic leukemia detected by fluorescence in situ hybridization (15052938)	Wasik-Szczepanek E.... Bojarska A.	2003	TP53, IGHV@
31	Clinical relevance of the expression of the CD31 ligand for CD38 in patients with B-cell chronic lymphocytic leukemia. (12673718)	Ibrahim S.... Albitar M.	2003	CD38, PECAM1
32	Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. (12011454)	Bichi R.... Croce C.M.	2002	TCL1A
33	Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX. (12200376)	Krackhardt A.M.... Gribben J.G.	2002	STUB1, TGS1, IKZF1
34	Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. (11675354)	Jones D.T.... Wickremasinghe R.G.	2001	CASP8, FAS, FASLG
35	Interleukins, TNF-alpha and beta-2M in patients with B cell chronic lymphocytic leukemia. (10089066)	Mavridis A.K.... Bourantas K.L.	1998	IL2
36	VH gene analysis of clonally related IgM and IgG from human lymphoplasmacytoid B-cell tumors with chronic lymphocytic leukemia features and high serum monoclonal IgG. (9414290)	Sahota S.S.... Stevenson F.K.	1998	IGHM
37	Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine. (9683281)	Narasimha Rao K.... Venkatachalam S.R.	1998	TYMS
38	Protection from apoptotic cell death by interleukin-4 is increased in previously treated chronic lymphocytic leukemia patients. (9029180)	Frankfurt O.S.... Villa L.	1997	IL4
39	Involvement of CED-3/ICE proteases in the apoptosis of B-chronic lymphocytic leukemia cells. (9129045)	Bellosillo B.... Gil J.	1997	BCL2, PARP1, IL4
40	Large granular lymphocyte leukemia (8937181)	Mizuki M.... Nojima J.	1996	FAM215A
41	Frequent somatic deletion of the 13q12.3 locus encompassing BRCA2 in chronic lymphocytic leukemia. (8781411)	Garcia-Marco J.A.... Catovsky D.	1996	BRCA2
42	Chlorambucil in chronic lymphocytic leukemia: mechanism of action. (9031099)	Begleiter A.... Johnston J.B.	1996	MDM2, TP53, BAX
43	Complete remission achieved by low-dose Ara-C, aclarubicin and rhG-CSF (CAG) therapy in acute non-lymphocytic leukemia with monosomy 7 occurring after severe aplastic anemia (7536277)	Yamato H.... Enokihara H.	1995	CSF3
44	DNA repair enzyme expression in chronic lymphocytic leukemia vis-A -vis nitrogen mustard drug resistance. (7736449)	Bramson J.... Panasci L.C.	1995	ERCC1
45	Serum levels of soluble intercellular adhesion molecule 1 are increased in chronic B-lymphocytic leukemia and correlate with clinical stage and prognostic markers. (7949173)	Christiansen I.... TAPtterman T.H.	1994	ICAM1, B2M, FCER2
46	Modalities of in vitro IgM and IgG production by peripheral blood lymphocytes of chronic lymphocytic leukemia patients and healthy volunteers. (8348071)	Poljak L.J.... Vitale B.	1993	CD40LG
47	High expression of the mdr3 multidrug-resistance gene in advanced-stage chronic lymphocytic leukemia. (1347708)	Sonneveld P.... van Dongen J.J.	1992	ABCB4
48	Rearrangements of immunoglobulin light and heavy chain genes and correlation with phenotypic markers in B-cell chronic lymphocytic leukemia. (1961033)	Lenormand B.... Lefranc M.P.	1991	CD19
49	Expression of CD23 antigen and its regulation by IL-4 in chronic lymphocytic leukemia. (2137545)	Sarfati M.... Biron G.	1990	IL4, FCER2
50	Altered signal transduction secondary to surface IgM cross-linking on B-chronic lymphocytic leukemia cells. Differential activation of the phosphatidylinositol-specific phospholipase C. (2107258)	Hivroz C.... Grillot-Courvalin C.	1990	PLCB1

Genes related to lymphocytic leukemia according to GeneCards:

(show top 50)    (show all 975)

id	Symbol	Description	Score	GeneCards Section Context
1	MME	membrane metallo-endopeptidase	11.1	Summaries, Publications, Aliases & Descriptions, UniProt Related
2	TAL2	T-cell acute lymphocytic leukemia 2	11.1	Transcripts, Proteins, Orthologs, Aliases & Descriptions (show all 5 sections) Summaries
3	TRIM13	tripartite motif containing 13	11.1	Publications, Aliases & Descriptions, UniProt Related, Summaries
4	RCBTB1	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1	11.1	Publications, Aliases & Descriptions, Summaries
5	CLLU1OS	chronic lymphocytic leukemia up-regulated 1 opposite strand	11.1	Publications, Aliases & Descriptions, Proteins
6	DLEU1	deleted in lymphocytic leukemia 1 (non-protein coding)	11.1	Transcripts, Publications, Aliases & Descriptions
7	DLEU2	deleted in lymphocytic leukemia 2 (non-protein coding)	11.1	Transcripts, Publications, Aliases & Descriptions, Orthologs
8	SETDB2	SET domain, bifurcated 2	11.1	Publications, Aliases & Descriptions
9	TAL1	T-cell acute lymphocytic leukemia 1	11.1	Transcripts, Aliases & Descriptions, Orthologs
10	BTG1	B-cell translocation gene 1, anti-proliferative	11.0	Publications, Functions, Summaries
11	FCRL2	Fc receptor-like 2	11.0	Publications, Summaries
12	BRWD3	bromodomain and WD repeat domain containing 3	11.0	Publications, Summaries
13	NUP98	nucleoporin 98kDa	11.0	Publications, Summaries
14	ANKS1B	ankyrin repeat and sterile alpha motif domain containing 1B	11.0	Functions, Summaries
15	CHST11	carbohydrate (chondroitin 4) sulfotransferase 11	11.0	Publications, Summaries
16	CLLU1	chronic lymphocytic leukemia up-regulated 1	11.0	Transcripts, Publications, Expressions, Aliases & Descriptions (show all 5 sections) Proteins
17	DLEU2L	deleted in lymphocytic leukemia 2-like	11.0	Transcripts, Publications, Aliases & Descriptions
18	SPRYD7	SPRY domain containing 7	11.0	Publications, Aliases & Descriptions, Orthologs
19	DLEU7	deleted in lymphocytic leukemia, 7	11.0	Transcripts, Aliases & Descriptions, Orthologs
20	RNASEH2B	ribonuclease H2, subunit B	11.0	Aliases & Descriptions, Orthologs
21	MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	11.0	Publications
22	ANPEP	alanyl (membrane) aminopeptidase	11.0	Publications
23	BCL2	B-cell CLL/lymphoma 2	11.0	Publications
24	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
25	CXCR4	chemokine (C-X-C motif) receptor 4	11.0	Publications
26	IL2	interleukin 2	11.0	Publications
27	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
28	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
29	TNF	tumor necrosis factor	11.0	Publications
30	GIMAP4	GTPase, IMAP family member 4	11.0	Summaries
31	CD38	CD38 molecule	11.0	Publications
32	TCL1A	T-cell leukemia/lymphoma 1A	11.0	Publications
33	CD79B	CD79b molecule, immunoglobulin-associated beta	11.0	Publications
34	MS4A1	membrane-spanning 4-domains, subfamily A, member 1	11.0	Publications
35	TRG@	T cell receptor gamma locus	11.0	Publications
36	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
37	IGH@	immunoglobulin heavy locus	11.0	Publications
38	ATM	ataxia telangiectasia mutated	11.0	Publications, Functions
39	BCR	breakpoint cluster region	11.0	Publications
40	RAP1GDS1	RAP1, GTP-GDP dissociation stimulator 1	11.0	Publications, Functions
41	SHMT1	serine hydroxymethyltransferase 1 (soluble)	11.0	Publications
42	TNFSF13B	tumor necrosis factor (ligand) superfamily, member 13b	11.0	Publications
43	BAX	BCL2-associated X protein	11.0	Publications
44	RAD51	RAD51 homolog (S. cerevisiae)	11.0	Publications
45	BIRC5	baculoviral IAP repeat containing 5	11.0	Publications
46	CASP8	caspase 8, apoptosis-related cysteine peptidase	11.0	Publications
47	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
48	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
49	IL15	interleukin 15	11.0	Publications
50	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications

Pathways related to lymphocytic leukemia according to GeneDecks:

(show top 50)    (show all 406)

id	Pathway	Score	Top Affiliating Genes
1	MIF Regulation of Innate Immune Cells36	18.0	BTK, BMP6, BCL2, BAX, CD2, CD14
2	MIF Mediated Glucocorticoid Regulation36	17.9	BTK, BMP6, BCL2, BAX, CD2, CD14
3	NF-KappaB Family Pathway36	17.5	REL, RELA, RELB, KITLG, VEGFC, VAV3
4	Regulation of eIF4 and p70S6K36	17.5	BTK, VEGFC, BAX, CD2, CD4, CD80
5	NFAT in Immune Response36	15.8	KIT, KITLG, BTK, VEGFC, BMP6, BLNK
6	Cell cycle20	15.7	SFN, BUB1B, RB1, RBL2, MYC, RAD21
7	DHA Signaling36	15.6	KIT, KITLG, VEGFC, BMP6, BID, BIK
8	Chagas disease (American trypanosomiasis)20	15.5	PIK3CD, PIK3CA, PIK3CG, RELA, MYD88, CHUK
9	Colorectal Cancer Metastasis36	15.2	BRAF, MYC, BIRC5, BCL2L1, LEF1, BAX
10	Small cell lung cancer20	15.0	PIK3CD, PIK3CA, PIK3CG, RELA, RB1, MYC
11	Immune response_BCR pathway41	14.7	PIK3CD, PIK3CA, REL, RELA, RELB, BTK
12	Chronic myeloid leukemia20	14.7	PIK3CD, PIK3CA, PIK3CG, RELA, RB1, BRAF
13	Renin-Angiotensin Pathway36	14.6	KIT, KITLG, VEGFC, VCAM1, BMP6, RAF1
14	Rap1 Pathway36	14.5	KITLG, BRAF, VEGFC, BMP6, RAF1, ZAP70
15	p53 Signaling36	14.3	SFN, BCL2, CHEK2, BAX, ATR, ATM
16	Melanoma20	14.1	PIK3CD, PIK3CA, PIK3CG, RB1, BRAF, RAF1
17	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway10	13.9	REL, RELA, RELB, BCL2, BCL2A1, BCL2L1
18	Immune response CD16 signaling in NK cells10	13.9	PIK3CD, PIK3CA, RAF1, ZAP70, LCK, FOS
19	NOD-like receptor signaling pathway20	13.9	RELA, BIRC2, BIRC3, CHUK, XIAP, IL18
20	Immune response_IL-4 signaling pathway41	13.8	PIK3CD, PIK3CA, REL, RELA, RELB, RAF1
21	Ras Pathway36	13.6	KIT, BRAF, VEGFC, RAF1, RASA1, KDR
22	Apoptosis and survival APRIL and BAFF signaling10	13.6	RELA, RELB, BCL2, BCL2A1, BCL2L1, CHUK
23	Malaria20	13.5	SELP, VCAM1, MYD88, SDC1, CD36, CD81
24	Development_IGF-1 receptor signaling41	13.3	PIK3CD, PIK3CA, REL, RELA, RELB, MYC
25	Immune response CD28 signaling10	13.2	PIK3CD, PIK3CA, REL, RELA, RELB, BCL2L1
26	Immune response_IL-12-induced IFN-gamma production41	13.2	REL, RELA, RELB, CHUK, JAK2, IL12A
27	Immune response_IL-2 activation and signaling pathway41	13.2	PIK3CD, PIK3CA, REL, RELA, RELB, MYC
28	Development PDGF signaling via STATs and NF-kB10	13.1	PIK3CD, PIK3CA, REL, RELA, RELB, MYC
29	Development Thrombopoietin-regulated cell processes10	13.0	PIK3CD, PIK3CA, BRAF, MYC, RAF1, BIRC5
30	TNF-Induced Apoptosis Implicating Sphingolipids36	12.9	RAF1, BAD, BAX, FADD, MAPK8, MAP2K3
31	Transcription_P53 signaling pathway41	12.7	REL, RELA, RELB, RB1, VEGFA, KDR
32	Development EPO-induced Jak-STAT pathway10	12.5	MYC, RAF1, RASA1, BCL2, BCL2L1, XIAP
33	Development_EPO-induced Jak-STAT pathway41	12.5	MYC, RASA1, BCL2, BCL2L1, XIAP, JAK2
34	CREB Pathway36	12.5	KIT, KITLG, BMP6, KDR, FLT4, FGF1
35	Immune response IL-9 signaling pathway10	12.4	PIK3CD, RELA, RAF1, BCL3, JAK1, GRB2
36	Development_VEGF signaling and activation41	12.2	PIK3CA, REL, RELA, RELB, VEGFA, VCAM1
37	Acute myeloid leukemia20	12.2	PIK3CD, PIM2, PIK3CA, PIK3CG, KIT, BRAF
38	Development GDNF family signaling10	12.0	PIK3CD, PIK3CA, REL, RELB, RAF1, RASA1
39	Development_ERBB-family signaling41	11.8	PIK3CD, PIK3CA, REL, RELB, RAF1, FOS
40	Fc epsilon RI signaling pathway20	11.8	PIK3CD, PIK3CA, PIK3CG, BTK, VAV3, GRB2
41	Immune response_NFAT in immune response41	11.7	PIK3CD, RELB, CD28, GSK3B, IKBKB, IGLV@
42	Development_VEGF signaling via VEGFR2 - generic cascades41	11.7	PIK3CD, PIK3CA, RELA, VEGFA, RAF1, RASA1
43	Translation Non-genomic (rapid) action of Androgen Receptor10	11.7	REL, RELA, RELB, RAF1, FOXO3, GRB2
44	Translation Regulation activity of EIF4F10	11.5	PIK3CD, MAP2K3, AKT2, AKT3, PDPK1, RHEB
45	EGFR Inhibitor Pathway, Pharmacodynamics34	11.0	PLCG2, KRAS, STAT5A
46	Immune System38	INF	NCAM1, PDCD1LG2, REL, KIR2DL1, KIR2DL3, KIR3DL1
47	Apoptosis and survival Anti-apoptotic TNFs/NF-kB/IAP pathway10	INF	REL, RELA, RELB, BIRC2, BIRC3, BIRC5
48	p38 Signaling36	INF	KIT, KITLG, BTK, VEGFC, BMP6, KDR
49	Immune response_IFN gamma signaling pathway41	INF	PIK3CD, PIK3CA, MYC, JAK1, JAK2, CDKN1A
50	Molecular Mechanisms of Cancer36	INF	PIK3CG, KITLG, BTK, RB1, VEGFC, MYC

Compounds related to lymphocytic leukemia according to GeneDecks:

(show top 50)    (show all 416)

id	Compound	Score	Top Affiliating Genes
1	nitric oxide32 9 18 9	INF	NCAM1, PDE3B, PDE4A, REL, KIT, KITLG
2	estradiol32 9 18 9	INF	KITLG, RB1, VIM, BRCA2, VEGFC, BOK
3	cholesterol32 9 18 9	24.9	PIK3CA, PDE3B, RECK, KITLG, RB1, SELP
4	pd 98,05932	21.3	PIK3CA, PIK3CG, NCL, PDE4A, RECK, KIT
5	arsenite32 18	19.4	PIK3CA, PIK3CG, CNTN2, VEGFA, MYC, BIRC2
6	methotrexate32 34 42 9 9	20.8	KIT, KITLG, RB1, VIM, NAT2, BRCA2
7	fmlp32	16.8	PIK3CG, PDE4A, SELL, SELP, SELPLG, VIM
8	matrigel32	15.9	PIK3CA, PIK3CG, NCAM1, RB1, SERPINB5, VIM
9	calcitriol32 42 9 18 9	19.9	KITLG, SFRP4, RB1, MYC, BMP6, PAX5
10	ceramide32	15.7	PIK3CA, PDE3B, CNTN2, RB1, RAF1, BID
11	thapsigargin32 42	16.5	PIK3CG, BTK, LPAR3, MYB, RAF1, BLZF1
12	zidovudine32 9 9	16.8	CNTN2, KITLG, LPL, MYC, LBR, B2M
13	phosphotyrosine32	14.7	PIK3CA, PIK3CG, RECK, KIT, KIR3DL1, BTK
14	phorbol32	14.6	REL, SELL, MYC, MYB, RAF1, CHUK
15	hydrogen32 18	15.6	PDE4A, KIR3DL1, BTK, SELPLG, RAD51, BCR
16	mitomycin c32	14.6	RB1, NBN, BRCA2, VCAM1, RAD51, BIRC5
17	hydrocortisone32 9 9	16.5	KITLG, VIM, BMP6, PBX1, KDR, CD36
18	ionomycin32	14.4	CNTN2, BTK, RAG1, BCL10, CHUK, LCK
19	ccl332	14.3	XCL1, MMP9, IL10, IL11, IL13, IL15
20	pentoxifylline32 9 9	16.1	PDE3B, PDE4A, PDE4B, SELL, SELP, VCAM1
21	rosiglitazone32 9 18 9	17.1	PIK3CA, PIK3CG, LPL, VCAM1, JAK2, CDKN1A
22	sulforaphane32	13.8	PIK3CG, RB1, PARP1, CDKN1A, CDC25C, GSTM1
23	geldanamycin32 9 9	15.6	PIK3CG, BRAF, VEGFA, RAF1, BIRC5, PARP1
24	anisomycin32 42 9 9	16.4	PIK3CG, MYC, RAF1, MTOR, CFLAR, FOS
25	diphenyleneiodonium32	13.2	VEGFA, VCAM1, MPO, IL1B, IL8, MAPK8
26	peptidoglycan32	13.1	PIK3CA, VDAC1, MYD88, CHUK, CD14, IL10
27	glyceraldehyde 3-phosphate32	13.0	VEGFC, VDAC1, MYCN, BLZF1, BIRC5, MX1
28	z-vad-fmk32 42	14.0	PARP1, BCL2, BCL2L1, BAX, GZMB, ANXA5
29	valine32	13.0	KIT, VIM, BRAF, LPL, RAF1, MTHFR
30	sorafenib32 9 9	14.8	KIT, BRAF, VHL, VEGFA, RAF1, BIRC3
31	latex32	12.7	CNTN2, KITLG, SELPLG, VDAC1, BLZF1, CHEK2
32	c2ceramide32	12.6	PIK3CG, PARP1, BCL2L1, CHUK, BAX, GSTA2
33	il-1232	12.5	CD86, CD40LG, IL10, IL12RB1, IL13, IL15
34	mifepristone32 42 9 9	15.3	BIRC5, BCL2A1, BCL2L1, LCK, BAX, LBR
35	fluvastatin32 34 9 9	15.3	SELP, LPL, VCAM1, CD40, ITGAL, MMP1
36	nocodazole32 42 9 9	15.2	NCL, BUB1B, VIM, RAF1, RAN, BIRC5
37	silymarin32	11.9	VEGFA, BMP6, BIRC5, PARP1, CHUK, CDK6
38	methionine32	11.9	RECK, KIT, VIM, VDAC1, MYB, LBR
39	manumycin32	11.4	RAF1, CHUK, ANXA5, MAPK8, MAPK14, DYT10
40	creatinine32	INF	NCAM1, KITLG, SELL, SELP, SERPINC1, VDAC1
41	adenine32 9 18 9	INF	PDE3B, NAT1, NAT2, BRAF, MYB, RAD51
42	polyinosinic-polycytidylic acid32	INF	VCAM1, CD83, CD40, , IL10, IL15
43	chloramphenicol32 9 9	INF	REL, CNTN2, SERPINC1, VIM, LPL, MYC
44	cysteine32	INF	RECK, REL, CNTN2, BTK, SELP, SELPLG
45	calcium32 9 18 9	INF	PIK3CD, NCL, PDE3B, PDE4A, RECK, REL
46	thymidine32 18	INF	PIK3CA, PDE3B, CNTN2, KIT, KITLG, RB1
47	tetracycline32 9 9	INF	CNTN2, GCNT1, RB1, MYCN, CDK2, CDKN2A
48	glucose32	INF	PDE4A, KIT, BRAF, VHL, VEGFC, BID
49	paraffin32	INF	NCAM1, RELA, KIT, KITLG, RB1, SELL
50	atp32	INF	PIK3CA, NCAM1, NCL, PDE3B, PDE4A, RECK

Cellular components related to lymphocytic leukemia according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	PIK3CD, PIK3CA, PIK3CG, NCKAP1L, PDE3B, PDE4A
2	nucleoplasm	GO:005654	INF	REL, RELA, REV1, RB1, RBL2, NBN
3	integral to plasma membrane	GO:005887	25.1	NCKAP1L, SGCE, CNTN2, KIR2DL1, KIR2DL3, KIR3DL1
4	external side of plasma membrane	GO:009897	18.0	NCAM1, KIT, SELL, SELP, VCAM1, KDR
5	membrane	GO:016020	16.4	PIK3CG, NCKAP1L, PDE3B, PDE4A, RECK, GCC2
6	cell surface	GO:009986	15.4	NCAM1, CNTN2, SFRP1, SFRP4, VEGFA, LPAR1
7	membrane raft	GO:045121	12.8	BTK, BCL10, LCK, P2RX7, JAK2, CD79A
8	extracellular space	GO:005615	INF	KIT, KITLG, SFN, SFRP1, SFRP2, SFRP4
9	cytoplasm	GO:005737	INF	PIK3CG, RELA, SGCE, KIT, KITLG, SFN
10	nucleus	GO:005634	INF	ZNF382, RFX7, NCL, PDE4A, PDE4B, RELA
11	extracellular region	GO:005576	INF	NCAM1, PDCD1LG2, KITLG, SERPINC1, SEMG1, SEPN1
12	plasma membrane	GO:005886	INF	PIK3CD, PIK3CG, PIGU, NCAM1, PDCD1LG2, RECK

Biological processes related to lymphocytic leukemia according to GeneDecks:

(show top 50)    (show all 89)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine-mediated signaling pathway	GO:019221	INF	NCAM1, RELA, KIT, VCAM1, MYD88, MX1
2	negative regulation of cell proliferation	GO:008285	INF	PIM2, SFN, SFRP1, SFRP2, SFRP4, SFRP5
3	signal transduction	GO:007165	INF	PIK3CD, PDE4A, PDE4B, KIT, KITLG, SFN
4	apoptotic process	GO:006915	22.9	SFN, SFRP5, BUB1B, BTK, NBN, VIM
5	immune response	GO:006955	22.4	PDCD1LG2, KIR2DL1, KIR2DL3, KIR3DL1, SEMA4D, BMP6
6	innate immune response	GO:045087	18.7	PIK3CD, PIK3CG, RELA, BTK, MYD88, BCL10
7	inflammatory response	GO:006954	18.5	PIK3CD, PIK3CG, RELA, KIT, SELP, MYD88
8	negative regulation of apoptotic process	GO:043066	17.5	PIK3CG, NCKAP1L, RELA, SFRP1, BRAF, VEGFA
9	cell-cell signaling	GO:007267	17.5	SFRP2, LILRB2, XCL1, CD33, CD70, CD86
10	positive regulation of cell proliferation	GO:008284	17.4	KIT, SFRP1, SFRP2, NBN, VEGFA, VEGFC
11	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	16.6	PIM2, REL, RELA, LPAR1, MYD88, BIRC2
12	anti-apoptosis	GO:006916	16.4	PIM2, PIK3CA, RELA, SEMA4D, BRAF, VHL
13	virus-host interaction	GO:019048	16.2	RELA, RB1, VIM, VDAC1, VCAM1, RAN
14	response to drug	GO:042493	16.1	NCKAP1L, PDE4A, SFRP1, SFRP2, NBN, VEGFC
15	regulation of immune response	GO:050776	15.5	KIR2DL1, KIR2DL3, KIR3DL1, SELL, VCAM1, LILRB2
16	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	14.8	BOK, MYC, BCL2L11, BBC3, LCK, BAD
17	response to hypoxia	GO:001666	14.7	VEGFA, VCAM1, RAF1, BCL2, XRCC1, ATM
18	cell surface receptor signaling pathway	GO:007166	14.3	MYD88, LILRB2, BIRC2, BIRC3, BAG1, LAG3
19	toll-like receptor signaling pathway	GO:002224	14.1	RELA, BTK, MYD88, BCL10, CHUK, UBE2N
20	activation of pro-apoptotic gene products	GO:008633	14.1	MYC, BMF, BID, BCL2, BCL2L11, BBC3
21	Toll signaling pathway	GO:008063	14.0	RELA, BTK, MYD88, CHUK, UBE2N, CD14
22	induction of apoptosis by intracellular signals	GO:008629	14.0	MYC, BMF, BID, BCL2, BCL2L1, BCL2L11
23	angiogenesis	GO:001525	13.9	PIK3CA, PIK3CG, NCL, PDE3B, VEGFA, VEGFC
24	toll-like receptor 4 signaling pathway	GO:034142	13.9	RELA, BTK, MYD88, CHUK, UBE2N, CD14
25	activation of MAPK activity	GO:000187	13.7	KIT, LPAR1, LPAR2, LPAR3, P2RX7, FRS2
26	MyD88-dependent toll-like receptor signaling pathway	GO:002755	13.7	RELA, BTK, MYD88, CHUK, UBE2N, CDK1
27	insulin receptor signaling pathway	GO:008286	13.6	PIK3CA, PDE3B, RAF1, MTOR, FRS2, CDK1
28	toll-like receptor 2 signaling pathway	GO:034134	13.6	RELA, BTK, MYD88, CHUK, UBE2N, CDK1
29	positive regulation of ERK1 and ERK2 cascade	GO:070374	13.5	BRAF, KDR, CD74, CD44, FLT4, MIF
30	positive regulation of B cell proliferation	GO:030890	13.5	NCKAP1L, VAV3, BCL2, BCL6, CDKN1A, CD40LG
31	toll-like receptor 3 signaling pathway	GO:034138	13.4	RELA, CHUK, CD14, CDK1, FOS, IRAK2
32	TRIF-dependent toll-like receptor signaling pathway	GO:035666	13.4	RELA, CHUK, CD14, CDK1, FOS, IRAK2
33	leukocyte migration	GO:050900	13.2	PIK3CA, SELL, SELP, SELPLG, LCK, CD58
34	nerve growth factor receptor signaling pathway	GO:048011	13.2	PIK3CA, RELA, BRAF, VAV3, MYD88, RAF1
35	T cell costimulation	GO:031295	13.0	PIK3CA, PDCD1LG2, LCK, MTOR, CD28, CD86
36	response to gamma radiation	GO:010332	13.0	BRCA2, MYC, LIG4, BCL2, CHEK2, BAK1
37	fibroblast growth factor receptor signaling pathway	GO:008543	12.9	PIK3CA, BRAF, RAF1, CHUK, BAD, MTOR
38	platelet activation	GO:030168	12.9	PIK3CA, PIK3CG, SELP, VEGFA, VEGFC, VAV3
39	positive regulation of T cell proliferation	GO:042102	12.8	NCKAP1L, PDCD1LG2, VCAM1, LILRB2, CD28, CD1D
40	lipopolysaccharide-mediated signaling pathway	GO:031663	12.8	MYD88, IRAK2, IL18, IL1B, MAPK3, MAPK14
41	peptidyl-tyrosine phosphorylation	GO:018108	12.2	KIT, BTK, KDR, ZAP70, JAK1, JAK2
42	epidermal growth factor receptor signaling pathway	GO:007173	11.9	PIK3CA, RAF1, CHUK, BAD, MTOR, CDKN1B
43	positive regulation of transcription, DNA-dependent	GO:045893	INF	PIM2, REL, RELA, SFRP1, RB1, BRCA2
44	blood coagulation	GO:007596	INF	PIK3CA, PIK3CG, PDE3B, SELL, SELP, SELPLG
45	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	RELA, SFRP2, RB1, VEGFA, MYC, MYCN
46	protein phosphorylation	GO:006468	INF	PIK3CD, PIM2, BTK, BRAF, RAF1, BIRC5
47	cell cycle arrest	GO:007050	INF	BTG4, RB1, RBM38, NBN, MYC, MSH2
48	positive regulation of apoptotic process	GO:043065	INF	SFRP1, SFRP2, SFRP4, LPAR1, BID, PAWR
49	positive regulation of NF-kappaB transcription factor activity	GO:051092	INF	RELA, BTK, MYD88, BCL10, CHUK, UBE2N
50	induction of apoptosis	GO:006917	INF	BOK, BIK, PAWR, BCL10, BCL2L11, MX1

Molecular functions related to lymphocytic leukemia according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:005524	21.0	PIK3CD, PIM2, PIK3CA, PIK3CG, KIT, BUB1B
2	protein homodimerization activity	GO:042803	16.7	KIT, VEGFA, RAG1, RAP1GAP, BIRC5, BCL11A
3	receptor activity	GO:004872	16.3	KIR2DL1, KIR2DL3, SEMA4D, LILRB4, LILRB2, CD33
4	cytokine activity	GO:005125	15.8	KITLG, VEGFA, BMP6, CD70, CD40LG, MIF
5	protein heterodimerization activity	GO:046982	15.6	BRAF, VEGFA, BOK, MYC, BMP6, RAF1
6	identical protein binding	GO:042802	15.5	RELA, CNTN2, SFRP1, GCC2, BTK, VIM
7	protein kinase binding	GO:019901	15.2	RELA, VIM, BCL10, BCL2L1, CHEK2, LCK
8	receptor binding	GO:005102	14.8	SELPLG, SEMA4D, LPL, RASA1, P2RX7, JAK2
9	growth factor activity	GO:008083	13.9	KITLG, VEGFA, VEGFC, BMP6, JAG2, FGF1
10	transcription factor binding	GO:008134	13.9	RELA, RB1, NBN, VHL, MYC, PBX1
11	enzyme binding	GO:019899	13.5	BTG1, VHL, BLZF1, BIRC5, BIRC7, PAWR
12	protein kinase activity	GO:004672	13.0	PIK3CG, BUB1B, BRAF, RAF1, CHUK, AURKA
13	tumor necrosis factor receptor binding	GO:005164	12.8	CD70, CD40LG, FASLG, FADD, CASP8, TRAF2
14	transmembrane signaling receptor activity	GO:004888	INF	SEMA4D, LAG3, CD79A, CD27, CD69, CD79B
15	protein binding	GO:005515	INF	PIK3CD, PIK3CA, PIK3CG, NCKAP1L, NCL, PDE3B