MCID: LYM006
MIFTS: 53

Lymphoepithelioma-Like Carcinoma malady

Immune diseases, Cancer diseases categories

Summaries for Lymphoepithelioma-Like Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of... more...

MalaCards: Lymphoepithelioma-Like Carcinoma, also known as lymphoepithelial carcinoma, is related to bladder carcinoma and papilloma. An important gene associated with Lymphoepithelioma-Like Carcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Colorectal Cancer Metastasis and Apoptosis Pathway. The compounds estrogen and aristolochic acid have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and cervix, and related mouse phenotypes are tumorigenesis and integument.

Disease Ontology:8 A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells.

Aliases & Classifications for Lymphoepithelioma-Like Carcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphoepithelioma-like carcinoma 8
lymphoepithelial carcinoma 8 60
nasopharyngeal type undifferentiated carcinoma 8


External Ids:

Disease Ontology8 DOID:5660
SNOMED-CT56 7300000
NCIt39 C4107

Related Diseases for Lymphoepithelioma-Like Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Lymphoepithelioma-Like Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma31.2TP53, CDH1, CGB
2papilloma30.7TP53
3thymoma30.4PTPRC
4ulcerative colitis30.4TP53
5cholangiocarcinoma30.4CGB, MUC1, CDH1, ALPP, TP53
6adenocarcinoma30.4VIM, EGFR, CGB, MUC1, CDH1, ACPP
7squamous cell carcinoma30.3VIM, EGFR, CGB, MUC1, CDH1, ACPP
8prostatitis30.2ACPP
9hepatitis30.2ALPP
10gastritis30.2TP53
11histiocytosis30.2ACPP, S100B
12rheumatoid arthritis30.2PTPRC, TNFRSF8
13mycosis fungoides30.2TNFRSF8
14arthritis30.2ACPP, ALPP
15spindle cell carcinoma30.2VIM, MUC1
16anaplastic large cell lymphoma30.2TNFRSF8, MUC1, PTPRC
17hodgkin's lymphoma30.2TNFRSF8, PTPRC, BCL2
18lung cancer30.2TP53, BCL2, CGB, EGFR
19hepatocellular carcinoma30.2CDH1, BCL2, ALPP, TP53
20colorectal cancer30.2EGFR, CDH1, BCL2, TP53
21colon cancer30.2EGFR, CDH1, BCL2, TP53
22breast cancer30.1TNFRSF8, EGFR, CGB, MUC1, CDH1, ACPP
23lymphoepithelioma-like thymic carcinoma10.5
24in situ carcinoma10.5
25renal pelvis carcinoma10.5
26cervical lymphoepithelioma-like carcinoma10.5
27infiltrating bladder lymphoepithelioma-like carcinoma10.4
28nasopharyngitis10.4
29thymic carcinoma10.4
30breast lymphoma10.3
31large cell carcinoma10.3
32basal cell carcinoma10.3
33thyroiditis10.3
34keratinizing squamous cell carcinoma10.2
35papillary carcinoma10.2
36stomach carcinoma in situ10.2
37pleomorphic carcinoma10.2
38gastric lymphoma10.2
39silicosis10.2
40tonsillitis10.2
41adenosquamous carcinoma10.2
42hepatitis a10.2
43bile duct carcinoma10.2
44cervicitis10.2
45intrahepatic cholangiocarcinoma10.2
46langerhans-cell histiocytosis10.2
47middle ear carcinoma10.2
48nephrotic syndrome10.2
49papillary thyroid carcinoma10.2
50lymphangitis10.1

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Carcinoma:



Diseases related to lymphoepithelioma-like carcinoma

Clinical Features for Lymphoepithelioma-Like Carcinoma

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Drugs & Therapeutics for Lymphoepithelioma-Like Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lymphoepithelioma-Like Carcinoma

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Anatomical Context for Lymphoepithelioma-Like Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Lymphoepithelioma-Like Carcinoma:

32
Lung, Skin, Cervix, Breast, Salivary gland, Colon, Ovary, Lymph node, Thyroid, Trachea, Kidney, Prostate, Testes, Thymus, Tonsil, T cells, B cells

Animal Models for Lymphoepithelioma-Like Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphoepithelioma-Like Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5PTPRC, CDH1, EGFR
2MP:00107718.4S100B, CDH1, ACPP, BCL2, TP53
3MP:00053818.3MUC1, CDH1, PTPRC, BCL2, TP53, EGFR
4MP:00028737.2TP53, RPL22, S100B, EGFR, MUC1, CDH1
5MP:00053876.6RPL22, VIM, TNFRSF8, EGFR, CDH1, PTPRC

Publications for Lymphoepithelioma-Like Carcinoma

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50PubMed
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Articles related to Lymphoepithelioma-Like Carcinoma:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
Lymphoepithelioma-like Carcinoma of the Endometrium: Immunophenotypic Characterization of a Rare Tumor With Microsatellite Instability Testing. (24300538)
2014
2
Lymphoepithelioma-like carcinoma of the bladder: a case report and review of the literature. (23710410)
2013
3
Computed tomography characteristics of primary pulmonary lymphoepithelioma-like carcinoma in 41 patients. (23465736)
2013
4
Lymphoepithelioma-like carcinoma of the renal pelvis: Pathological and therapeutic implications. (24069102)
2013
5
Gastric lymphoepithelioma-like carcinoma mimicking a subepithelial lesion treated by endoscopic submucosal dissection. (22817794)
2012
6
Cytopathologic features and differential diagnostic considerations of primary lymphoepithelioma-like carcinoma of the lung. (21433005)
2012
7
Primary lymphoepithelioma-like carcinoma of the lung: report of a rare case and review of the literature. (23011835)
2012
8
Unique p53 and epidermal growth factor receptor gene mutation status in 46 pulmonary lymphoepithelioma-like carcinomas. (21070477)
2011
9
Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique. (21219641)
2011
10
Lymphoepithelioma-like carcinoma of the breast. (20194945)
2010
11
Lymphoepithelioma-like carcinoma of the endometrium. (23596758)
2010
12
Primary cutaneous lymphoepithelioma-like carcinoma treated using Mohs micrographic surgery and zinc chloride fixative. (20236296)
2010
13
Pleomorphic lymphoepithelioma-like carcinoma of the urinary bladder. (19079656)
2009
14
Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung. (19704339)
2009
15
Lymphoepithelioma-like carcinoma of the prostate. (19269013)
2009
16
Lymphoepithelioma-like carcinoma of the breast: diagnosis by core needle biopsy. (19824996)
2009
17
Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature. (17979492)
2007
18
Lymphoepithelioma-like carcinoma of the renal pelvis. (18036048)
2007
19
Lymphoepithelioma-like carcinoma of the urinary bladder--diagnostic and clinical implications. (17347662)
2007
20
A case of lymphoepithelioma-like carcinoma of the colon with ulcerative colitis. (17351809)
2007
21
Lymphoepithelioma-like carcinoma of the trachea. (17592428)
2007
22
Primary lymphoepithelioma-like carcinoma of minor salivary gland: a case report with immunohistochemical and in situ hybridization studies. (16240326)
2006
23
Lymphoepithelioma-like carcinoma of the lung: radiologic features of an uncommon primary pulmonary neoplasm. (16632721)
2006
24
Lymphoepithelioma-like carcinoma of the breast mimicking nodular sclerosing Hodgkin's lymphoma. (16174158)
2005
25
Lymphoepithelioma-like carcinoma of the ureter. (16286140)
2005
26
Primary lymphoepithelioma-like carcinoma of the lung. (15765291)
2005
27
Hepatocellular lymphoepithelioma-like carcinoma associated with epstein barr virus: a hitherto unrecognized entity. (15322431)
2004
28
Lymphoepithelioma-like carcinoma of the submandibular salivary gland associated with Epstein-Barr virus in a North African woman. (15258757)
2004
29
Lymphoepithelioma-like carcinoma of the bladder: three cases with clinicopathological and p53 protein expression study. (15067546)
2004
30
Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis. (12952277)
2003
31
Lymphoepithelioma-like carcinoma of the uterine cervix. (12456211)
2002
32
Lymphoepithelioma-like carcinoma of the breast. (12193205)
2002
33
Tracheal lymphoepithelioma-like carcinoma: a case report. (12928566)
2002
34
Lymphoepithelioma-like carcinoma of oral cavity: report of three cases and literature review. (12102423)
2002
35
Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. (11469686)
2001
36
Lymphoepithelioma-like carcinoma of the bladder. (11122005)
2001
37
Ectopic production and localization of beta-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix: a case report. (10782417)
2000
38
Lymphoepithelioma-like carcinoma of the stomach: a subset of gastric carcinoma with distinct clinicopathological features and high prevalence of Epstein-Barr virus infection. (10370694)
1999
39
Biliary lymphoepithelioma-like carcinoma not associated with Epstein-Barr virus. (10235506)
1999
40
Presence of Epstein-Barr virus in lymphoepithelioma-like carcinoma of the middle ear. (9828819)
1998
41
Enlarging facial nodule on an elderly patient. Lymphoepithelioma-like carcinoma of the skin (LELCS). (9875206)
1998
42
Lymphoepithelioma-like carcinoma of the skin. (8772027)
1996
43
Lymphoepithelioma-like carcinoma of the skin. (8989941)
1996
44
Gastric lymphoepithelioma-like carcinoma and jejunal B-cell MALT lymphoma with large cell transformation. Demonstration of EBV with identical LMP gene deletions in the carcinoma and large cell lymphoma. (8623763)
1996
45
Lymphoepithelioma-like carcinoma originating on the eyelid. (7738280)
1995
46
Primary lymphoepithelioma-like carcinoma of the lung. A clinicopathologic study of 11 cases. (8625122)
1995
47
Lymphoepithelioma-like carcinoma of the skin treated by Mohs micrographic surgery. (7722033)
1995
48
Lymphoepithelioma-like carcinoma of the skin. (8440065)
1993
49
Clonal Epstein-Barr virus in lymphoepithelioma-like carcinoma of the stomach: demonstration of viral genome by in situ hybridization and Southern blot analysis. (1369803)
1992
50
Lymphoepithelioma-like carcinoma and its relationship to Epstein-Barr virus. (1650531)
1991

Genetic Variations for Lymphoepithelioma-Like Carcinoma

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Expression for genes affiliated with Lymphoepithelioma-Like Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoepithelioma-Like Carcinoma

Search GEO for disease gene expression data for Lymphoepithelioma-Like Carcinoma.

Pathways for genes affiliated with Lymphoepithelioma-Like Carcinoma

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51QIAGEN, 59Tocris Bioscience, 29KEGG, 55SinoBiological, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1EGFR
210.1BCL2
3
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10.0TP53
4
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9.9TNFRSF8
59.8CDH1, EGFR
69.6TP53, BCL2
7
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9.6TP53, BCL2
89.4CGB, CDH1, TP53
9
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9.3PTPRC, BCL2, TP53
109.3TP53, EGFR, VIM
119.2EGFR, BCL2, TP53
12
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9.0BCL2, CDH1, MUC1, EGFR
139.0TP53, CDH1, MUC1, EGFR
148.9TP53, BCL2, EGFR, VIM
15
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8.9TP53, BCL2, CDH1, EGFR
16
Hide members
8.9TP53, BCL2, CDH1, EGFR
178.9EGFR, CDH1, BCL2, TP53
188.9EGFR, CDH1, BCL2, TP53
19
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8.5TNFRSF8, EGFR, CDH1, PTPRC, BCL2
20
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7.6VIM, TNFRSF8, EGFR, MUC1, CDH1, BCL2

Compounds for genes affiliated with Lymphoepithelioma-Like Carcinoma

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44Novoseek, 2BitterDB, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4ACPP
2aristolochic acid44 211.4VIM
3vincristine44 49 1112.4VIM
4glycogen44 2411.3PTPRC
5cycloheximide4410.3ALPP
6eosin4410.0VIM, S100B, MUC1
7s 100449.9MUC1, VIM, S100B
8sialic acid449.9PTPRC
9reticulin449.9MUC1, S100B, VIM
10adriamycin449.8BCL2, VIM, MUC1
11mucicarmine449.8VIM, S100B, MUC1
12tamoxifen44 49 28 1112.7EGFR, CDH1, ALPP
13temozolomide44 1110.5VIM, EGFR, TP53
14[alcl]449.5PTPRC, MUC1, TNFRSF8
15tartrate449.4ACPP, ALPP, VIM
16hydroxyapatite449.4VIM, S100B, CDH1, ALPP
17formaldehyde44 2410.4VIM, CDH1, S100B, MUC1, PTPRC
18suberoylanilide hydroxamic acid449.3BCL2, CDH1, EGFR, TP53
19vinblastine44 49 1111.3TP53, BCL2, CDH1, VIM
20creatinine449.3ACPP, CGB, ALPP, CDH1
21serine449.2CDH1, S100B, ACPP, ALPP
22taxane449.2EGFR, BCL2, TP53
23cytarabine44 49 1111.2VIM, MUC1, BCL2, TP53
24gemcitabine44 49 1111.2EGFR, BCL2, MUC1, TP53
25hematoxylin449.2ACPP, CDH1, VIM, S100B, PTPRC
26heparin44 28 11 2412.1PTPRC, CDH1, S100B, RPL22
27progestin449.0MUC1, EGFR, VIM, ALPP, CDH1
28dexamethasone44 49 28 1112.0BCL2, CDH1, S100B, PTPRC, ALPP
29paclitaxel44 49 1111.0BCL2, CDH1, EGFR, S100B, TP53
30thymidylate449.0TP53, EGFR, CDH1, BCL2, VIM
31agar449.0MUC1, EGFR, VIM, ACPP, CDH1
325fluorouracil448.9BCL2, TP53, CDH1, MUC1, EGFR
33n acetylcysteine448.9PTPRC, BCL2, EGFR, CDH1, TP53
34mg 13244 599.9TP53, CDH1, EGFR, BCL2
35b 723448.9ALPP, PTPRC, CDH1, MUC1, S100B, VIM
36etoposide44 49 59 1111.8S100B, CGB, VIM, CDH1, TP53, BCL2
37docetaxel44 49 59 1111.8BCL2, TP53, CDH1, EGFR
38doxorubicin44 49 1110.7CDH1, BCL2, TP53, VIM, EGFR
39genistein44 28 59 2 11 2413.6EGFR, PTPRC, CDH1, VIM, BCL2, ALPP
40lactate448.6CDH1, CGB, S100B, ACPP, ALPP, VIM
41retinoid448.5BCL2, ALPP, TP53, EGFR, VIM, CDH1
42cysteine448.5PTPRC, VIM, S100B, CGB, ALPP, CDH1
43sb 20358044 599.5BCL2, VIM, TP53, ALPP, CDH1, EGFR
44thymidine44 249.1TNFRSF8, TP53, ALPP, ACPP, MUC1, S100B
45retinoic acid44 248.9TP53, S100B, ALPP, VIM, BCL2, CDH1
46cisplatin44 49 59 1110.7CGB, MUC1, EGFR, CDH1, ACPP, BCL2
47testosterone44 59 11 2410.7MUC1, PTPRC, ACPP, VIM, S100B, EGFR
48progesterone44 59 28 11 2411.4EGFR, VIM, S100B, CGB, MUC1, TP53
49vegf447.1TP53, VIM, ALPP, BCL2, ACPP, CDH1
50paraffin446.5TP53, TNFRSF8, S100B, VIM, ACPP, MUC1

GO Terms for genes affiliated with Lymphoepithelioma-Like Carcinoma

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16Gene Ontology
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Cellular components related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.5TP53, BCL2, CDH1, MUC1, EGFR, TNFRSF8

Biological processes related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell lineage commitmentGO:0023269.7TP53, BCL2
2B cell proliferationGO:0421009.7PTPRC, BCL2
3digestive tract morphogenesisGO:0485469.7BCL2, EGFR
4regulation of mitochondrial membrane permeabilityGO:0469029.6BCL2, TP53
5DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4TP53, MUC1
6cell-cell adhesionGO:0163379.4BCL2, CDH1, EGFR

Molecular functions related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.6TP53, BCL2
2identical protein bindingGO:0428027.8TP53, BCL2, ACPP, EGFR, S100B, VIM

Products for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Sources for Lymphoepithelioma-Like Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet