MCID: LYM006
MIFTS: 54

Lymphoepithelioma-Like Carcinoma malady

Immune diseases, Cancer diseases categories

Summaries for Lymphoepithelioma-Like Carcinoma

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Wikipedia:65 Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of... more...

MalaCards based summary: Lymphoepithelioma-Like Carcinoma, also known as nasopharyngeal type undifferentiated carcinoma, is related to cholangiocarcinoma and nasopharyngeal carcinoma. An important gene associated with Lymphoepithelioma-Like Carcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are a6b1 and a6b4 Integrin signaling and E-cadherin signaling in keratinocytes. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and breast, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Disease Ontology:10 A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells.

Aliases & Classifications for Lymphoepithelioma-Like Carcinoma

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Lymphoepithelioma-Like Carcinoma, Aliases & Descriptions:

Name: Lymphoepithelioma-Like Carcinoma 10 62
Nasopharyngeal Type Undifferentiated Carcinoma 10 62
 
Lymphoepithelial Carcinoma 10 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology10 DOID:5660
SNOMED-CT57 7300000
NCIt40 C4107

Related Diseases for Lymphoepithelioma-Like Carcinoma

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Diseases related to Lymphoepithelioma-Like Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.6MUC1, TP53, CDH1, ALPP, CGB
2nasopharyngeal carcinoma30.5TP53, CDH1, EGFR, TNFRSF8
3adenocarcinoma30.4CGB, CDH1, EGFR, MUC1, VIM, TP53
4histiocytosis30.4ACPP, S100B
5anaplastic large cell lymphoma30.4TNFRSF8, PTPRC, MUC1
6breast cancer30.3TP53, CDH1
7adenosquamous carcinoma30.3EGFR, MUC1
8gastrointestinal stromal tumor30.3VIM, S100B
9lung cancer30.3EGFR, TP53, CGB
10colorectal cancer30.2MUC1, ALPP, CGB, TP53, EGFR, CDH1
11papilloma10.6
12sinonasal undifferentiated carcinoma10.5
13infiltrating bladder lymphoepithelioma-like carcinoma10.5
14lymphoepithelioma-like thymic carcinoma10.5
15cervical lymphoepithelioma-like carcinoma10.5
16nasopharyngitis10.5
17thyroiditis10.5
18ulcerative colitis10.4
19basal cell carcinoma10.4
20colitis10.4
21intrahepatic cholangiocarcinoma10.4
22thymoma10.4
23rheumatoid arthritis10.2
24arthritis10.2
25hepatitis10.2
26malt lymphoma10.2
27mycosis fungoides10.2
28silicosis10.2
29langerhans-cell histiocytosis10.2
30pemphigus10.2
31tonsillitis10.2
32papillary carcinoma10.2
33cervicitis10.2
34gastritis10.2
35nephrotic syndrome10.2
36prostatitis10.2
37carcinoma showing thymus-like differentiation10.2
38erythema elevatum diutinum10.2
39pulmonary sequestration10.2
40paraneoplastic syndromes10.2
41paraneoplastic pemphigus10.2
42lymphangitis10.1
43cerebellar degeneration10.1
44paraneoplastic cerebellar degeneration10.1
45giant cell tumor10.1ACPP
46hidradenoma10.1MUC1
47superior vena cava syndrome10.1CGB
48gemistocytic astrocytoma10.1S100B
49eccrine porocarcinoma10.1MUC1
50cystadenocarcinoma10.1MUC1

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Carcinoma:



Diseases related to lymphoepithelioma-like carcinoma

Symptoms for Lymphoepithelioma-Like Carcinoma

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Drugs & Therapeutics for Lymphoepithelioma-Like Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Lymphoepithelioma-Like Carcinoma

Search NIH Clinical Center for Lymphoepithelioma-Like Carcinoma

Genetic Tests for Lymphoepithelioma-Like Carcinoma

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Anatomical Context for Lymphoepithelioma-Like Carcinoma

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MalaCards organs/tissues related to Lymphoepithelioma-Like Carcinoma:

33
Skin, Lung, Breast, Cervix, Salivary gland, Colon, Thyroid, Ovary, Trachea, Lymph node, Thymus, Kidney, Prostate, Testes, Tonsil, T cells, B cells

Animal Models for Lymphoepithelioma-Like Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Lymphoepithelioma-Like Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6MUC1, TP53, CDH1, EGFR, PTPRC
2MP:00030128.5TP53, CDH1, EGFR, PTPRC, MUC1
3MP:00053818.5CDH1, EGFR, TP53, MUC1, PTPRC
4MP:00107718.4ACPP, EGFR, CDH1, S100B, MUC1, TP53
5MP:00053847.8PTPRC, EGFR, VIM, RPL22, CDH1, TP53
6MP:00053807.6TP53, VIM, EGFR, CDH1, ALPP
7MP:00053977.6TP53, VIM, TNFRSF8, RPL22, EGFR, PTPRC
8MP:00053877.4VIM, RPL22, PTPRC, EGFR, CDH1, TP53
9MP:00053787.1EGFR, ALPP, RPL22, VIM, TP53, PTPRC
10MP:00028736.9EGFR, RPL22, ALPP, S100B, CDH1, TP53

Publications for Lymphoepithelioma-Like Carcinoma

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Articles related to Lymphoepithelioma-Like Carcinoma:

(show top 50)    (show all 253)
idTitleAuthorsYear
1
Lymphoepithelioma-like carcinoma: A distinct type of gastric cancer. (25592274)
2015
2
PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: A potential rationale for immunotherapy. (25862146)
2015
3
Lymphoepithelioma-like Carcinoma of the Endometrium: Immunophenotypic Characterization of a Rare Tumor With Microsatellite Instability Testing. (24300538)
2014
4
Lymphoepithelioma-like carcinoma of the breast: Cytological, histological, and immunohistochemical characteristics. (24610805)
2014
5
Lymphoepithelioma-like carcinoma of the urinary bladder: a case report and review of the literature. (25367311)
2014
6
Intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell. (23176314)
2013
7
Lymphoepithelioma-like carcinoma of the breast: cytological and histological features and review of the literature. (22236751)
2012
8
Lymphoepithelioma-like carcinoma of the colon. (22295155)
2012
9
Lymphoepithelioma-like carcinoma in a patient with mycosis fungoides. (22527441)
2012
10
Lymphoepithelioma-like carcinoma of the skin treated with wide local excision and chemoradiation therapy: a case report and review of the literature. (23133769)
2012
11
Primary pulmonary lymphoepithelioma-like carcinoma: fifty-two patients with long-term follow-up. (22359203)
2012
12
Lymphoepithelioma-like carcinoma of the ovary. (20444729)
2011
13
Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature. (20952226)
2011
14
Cutaneous lymphoepithelioma-like carcinoma: report of three cases. (22295745)
2011
15
Primary lymphoepithelioma-like carcinoma of the ureter. (20471568)
2010
16
Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma. (21080882)
2010
17
Cytology of lymphoepithelioma-like carcinoma of the urinary bladder. (19456843)
2009
18
Lymphoepithelioma-like carcinoma of the uterine cervix. (19238413)
2009
19
Pleomorphic lymphoepithelioma-like carcinoma of the urinary bladder. (19079656)
2009
20
Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung. (19704339)
2009
21
Lymphoepithelioma-like carcinoma of the prostate. (19269013)
2009
22
Lymphoepithelioma-like carcinoma of the skin mimicking a basal cell carcinoma. (19106051)
2009
23
Thymic lymphoepithelioma-like carcinoma mimicking primary tumor of the lung. (19618760)
2009
24
Lymphoepithelioma-like carcinoma of the urinary bladder in a cow associated with bovine papillomavirus type-2. (18675990)
2008
25
Lymphoepithelioma-like carcinoma arising in the scar from a previously excised basal cell carcinoma. (18201243)
2008
26
Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature. (17979492)
2007
27
Primary lymphoepithelioma-like carcinoma of minor salivary gland: a case report with immunohistochemical and in situ hybridization studies. (16240326)
2006
28
Lymphoepithelioma-like carcinoma of the breast mimicking nodular sclerosing Hodgkin's lymphoma. (16174158)
2005
29
Lymphoepithelioma-like carcinoma of the breast: report of a case mimicking lymphoma. (15494940)
2004
30
Clinical role of circulating Epstein-Barr virus DNA as a tumor marker in lymphoepithelioma-like carcinoma of the lung. (15251971)
2004
31
Simultaneous EBV-positive lymphoepithelioma-like carcinoma and EBV-negative intestinal-type adenocarcinoma in a patient with Helicobacter pylori-associated chronic gastritis. (14983938)
2004
32
Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma. (12594554)
2003
33
Lymphoepithelioma-like carcinoma of the uterine cervix. (12456211)
2002
34
Lymphoepithelioma-like carcinoma of the breast. (12193205)
2002
35
Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. (11469686)
2001
36
Ectopic production and localization of beta-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix: a case report. (10782417)
2000
37
Lymphoepithelioma-like carcinoma of the uterine cervix: a case report studied by in situ hybridization and polymerase chain reaction for Epstein-Barr virus. (10782160)
2000
38
Case report: A case of lymphoepithelioma-like carcinoma of the oesophagus and review of the literature. (10385061)
1999
39
Case report of lymphoepithelioma-like carcinoma of the lung--lymphoid population consisting of cytotoxic T cells in resting state. (10605698)
1999
40
Lymphoepithelioma-like carcinoma of the colon: report of a case with histologic, immunohistochemical, and molecular studies for Epstein-Barr virus. (9678381)
1998
41
Expression of Epstein-Barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. (8600040)
1996
42
Lymphoepithelioma-like carcinoma of the lung. Two cases diagnosed in Caucasian patients. (7778219)
1995
43
Epstein-Barr virus is detected in undifferentiated nasopharyngeal carcinoma but not in lymphoepithelioma-like carcinoma of the urinary bladder. (7590694)
1995
44
Lymphoepithelioma-like carcinoma of the lung. (8822122)
1995
45
Fine-needle aspiration cytologic diagnosis of lymphoepithelioma-like carcinoma of the lung. Report of two cases with immunohistochemical study. (7817941)
1995
46
Lymphoepithelioma-like carcinoma of the urinary bladder. (8172321)
1994
47
Lymphoepithelioma-like carcinoma of the skin: a light-microscopic and immunohistochemical study. (7699121)
1994
48
Lymphoepithelioma-like carcinoma of the lung. (2546459)
1989
49
Lymphoepithelioma-like carcinoma of the skin. (3237711)
1988
50
Epstein-Barr virus related lymphoepithelioma-like carcinoma of lung. (2826922)
1987

Variations for Lymphoepithelioma-Like Carcinoma

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Expression for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Search GEO for disease gene expression data for Lymphoepithelioma-Like Carcinoma.

Pathways for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Pathways related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EGFR, CDH1
29.6CDH1, EGFR
39.6EGFR, CDH1
49.5CDH1, TP53
59.5EGFR, TP53
6
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.3EGFR, CDH1, MUC1
79.3TP53, CDH1, CGB
89.2TP53, VIM, CDH1
99.1EGFR, VIM, TP53
109.1EGFR, CDH1, TP53
11
Show member pathways
Signal transduction PTEN pathway60
9.1TP53, CDH1, EGFR
12
Show member pathways
Signaling Pathways in Glioblastoma38
9.1EGFR, CDH1, TP53
139.1TP53, CDH1, EGFR
148.8EGFR, CDH1, MUC1, TP53
15
Show member pathways
8.8TNFRSF8, PTPRC, CDH1, EGFR
16
Show member pathways
7.9TNFRSF8, TP53, VIM, MUC1, CDH1, EGFR

Compounds for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Compounds related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1eosin459.9VIM, S100B, MUC1
2s 100459.8MUC1, S100B, VIM
3reticulin459.8VIM, MUC1, S100B
4mucicarmine459.8S100B, MUC1, VIM
5[alcl]459.6TNFRSF8, PTPRC, MUC1
6aristolochic acid45 310.5TP53, VIM, CDH1
7tartrate459.4ACPP, VIM, ALPP
8sialic acid459.4PTPRC, S100B, MUC1, CDH1
9temozolomide45 1310.3VIM, EGFR, TP53
10dihydrotestosterone45 30 26 1312.3MUC1, CDH1, ACPP, VIM
11hyaluronic acid45 2610.2MUC1, CDH1, PTPRC, VIM
12crcs459.2TP53, CDH1, MUC1
13adriamycin459.2TP53, VIM, CDH1, MUC1
14formaldehyde45 2610.1PTPRC, S100B, MUC1, CDH1, VIM
15agar459.0MUC1, EGFR, CDH1, ACPP, VIM
16glycogen45 2610.0CDH1, S100B, MUC1, VIM, PTPRC
17thymidylate459.0VIM, TP53, EGFR, CDH1
18etoposide45 51 61 1311.9CGB, TP53, CDH1, S100B, VIM
19acth458.9ACPP, PTPRC, MUC1, S100B
20hydroxyapatite458.9VIM, ALPP, CDH1, S100B
21hematoxylin458.9ACPP, MUC1, PTPRC, S100B, VIM, CDH1
22cyclic amp45 269.8VIM, CGB, S100B, MUC1, CDH1
23paclitaxel45 51 1310.7S100B, VIM, TP53, EGFR, CDH1
24folate458.7VIM, CDH1, MUC1, ALPP
25dmso458.6MUC1, ALPP, PTPRC, VIM
26progestin458.5CDH1, ALPP, EGFR, MUC1, VIM
27butyrate458.4TP53, ALPP, VIM, MUC1, CDH1
28lactate458.4CGB, CDH1, VIM, ACPP, ALPP, S100B
29genistein45 30 61 3 26 1313.4CDH1, PTPRC, EGFR, VIM, ALPP
30b 723458.4S100B, CDH1, ALPP, VIM, MUC1, PTPRC
31aspartate458.3ALPP, S100B, CDH1, VIM, ACPP
32retinoid458.3CDH1, ALPP, VIM, TP53, EGFR
33sb 20358045 619.3TP53, EGFR, CDH1, ALPP, VIM
34alanine458.3VIM, ACPP, ALPP, S100B, CDH1, CGB
35dexamethasone45 51 30 1311.2PTPRC, VIM, MUC1, ALPP, CDH1, S100B
36creatinine458.1ALPP, S100B, CDH1, ACPP, CGB, VIM
37thymidine45 269.1ALPP, S100B, MUC1, TP53, TNFRSF8, ACPP
38cysteine458.0S100B, CGB, CDH1, VIM, MUC1, ALPP
39arginine458.0VIM, ACPP, ALPP, S100B, CDH1, TP53
40tamoxifen45 51 30 1311.0EGFR, TP53, VIM, ALPP, CDH1, MUC1
41heparin45 30 26 1311.0CDH1, VIM, PTPRC, RPL22, ALPP, S100B
42tyrosine457.9EGFR, S100B, CDH1, MUC1, TNFRSF8, PTPRC
43cisplatin45 51 61 1310.8MUC1, ACPP, CDH1, EGFR, CGB, ALPP
44retinoic acid45 268.6MUC1, ALPP, TP53, VIM, EGFR, S100B
45progesterone45 30 61 26 1311.6MUC1, VIM, ACPP, S100B, EGFR, CGB
46testosterone45 61 26 1310.3VIM, ACPP, CDH1, MUC1, CGB, PTPRC
47vegf457.1TP53, EGFR, CGB, ALPP, ACPP, S100B
48estrogen456.8CDH1, ALPP, S100B, ACPP, PTPRC, VIM
49paraffin456.6MUC1, VIM, TNFRSF8, PTPRC, EGFR, CDH1
50serine456.6ACPP, CDH1, S100B, ALPP, MUC1, VIM

GO Terms for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Cellular components related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.4MUC1, ALPP, CDH1, EGFR
2extracellular vesicular exosomeGO:00700628.1RPL22, ACPP, MUC1, VIM, PTPRC, TNFRSF8
3plasma membraneGO:00058867.3PTPRC, VIM, ACPP, ALPP, CDH1, EGFR
4cytoplasmGO:00057376.6TNFRSF8, TP53, VIM, MUC1, RPL22, S100B

Biological processes related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.7MUC1, TP53
2learning or memoryGO:00076119.4EGFR, S100B
3dephosphorylationGO:00163119.1ALPP, ACPP, PTPRC
4positive regulation of apoptotic processGO:00430659.1S100B, TP53, TNFRSF8
5apoptotic processGO:00069158.8TP53, VIM, CDH1, CGB

Molecular functions related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:00019489.1EGFR, CDH1, VIM
2protein phosphatase bindingGO:00199038.8TP53, CDH1, EGFR
3identical protein bindingGO:00428028.5EGFR, S100B, ACPP, VIM, TP53
4protein bindingGO:00055157.5EGFR, CDH1, S100B, ACPP, MUC1, VIM

Products for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Sources for Lymphoepithelioma-Like Carcinoma

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27ICD10
28ICD10 via Orphanet
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