MCID: LYM006
MIFTS: 55

Lymphoepithelioma-Like Carcinoma malady

Cancer diseases, Immune diseases categories

Summaries for Lymphoepithelioma-Like Carcinoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of... more...

MalaCards: Lymphoepithelioma-Like Carcinoma, also known as lymphoepithelial carcinoma, is related to cholangiocarcinoma and histiocytosis. An important gene associated with Lymphoepithelioma-Like Carcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are a6b1 and a6b4 Integrin signaling and E-cadherin signaling in keratinocytes. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and cervix, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Disease Ontology:9 A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells.

Aliases & Classifications for Lymphoepithelioma-Like Carcinoma

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9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphoepithelioma-like carcinoma 9
lymphoepithelial carcinoma 9 63
nasopharyngeal type undifferentiated carcinoma 9


External Ids:

Disease Ontology9 DOID:5660
SNOMED-CT59 7300000
NCIt41 C4107

Related Diseases for Lymphoepithelioma-Like Carcinoma

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18GeneCards, 19GeneDecks
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Diseases related to Lymphoepithelioma-Like Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1cholangiocarcinoma30.5TP53, MUC1, ALPP, CDH1, CGB
2histiocytosis30.4ACPP, S100B
3anaplastic large cell lymphoma30.4TNFRSF8, PTPRC, MUC1
4adenosquamous carcinoma30.3EGFR, MUC1
5adenocarcinoma30.3CGB, EGFR, CDH1, ACPP, MUC1, VIM
6lung cancer30.2TP53, EGFR, CGB
7colorectal cancer30.1TP53, MUC1, ALPP, CDH1, EGFR, CGB
8breast cancer30.0TNFRSF8, TP53, MUC1, ACPP, ALPP, CDH1
9papilloma10.6
10sinonasal undifferentiated carcinoma10.4
11infiltrating bladder lymphoepithelioma-like carcinoma10.4
12cervical lymphoepithelioma-like carcinoma10.4
13nasopharyngitis10.4
14ulcerative colitis10.4
15lymphoepithelioma-like thymic carcinoma10.4
16basal cell carcinoma10.4
17thymoma10.4
18thyroiditis10.4
19langerhans-cell histiocytosis10.2
20silicosis10.2
21tonsillitis10.2
22mycosis fungoides10.2
23papillary carcinoma10.2
24arthritis10.2
25cervicitis10.2
26gastritis10.2
27hepatitis10.2
28hodgkin's lymphoma10.2
29intrahepatic cholangiocarcinoma10.2
30nephrotic syndrome10.2
31prostatitis10.2
32rheumatoid arthritis10.2
33carcinoma showing thymus-like differentiation10.2
34erythema elevatum diutinum10.2
35pulmonary sequestration10.2
36paraneoplastic syndromes10.2
37malt lymphoma10.2
38giant cell tumor10.1ACPP
39hidradenoma10.1MUC1
40superior vena cava syndrome10.1CGB
41gemistocytic astrocytoma10.1S100B
42eccrine porocarcinoma10.1MUC1
43cystadenocarcinoma10.1MUC1
44rosai-dorfman disease10.1S100B
45lymphangitis10.1
46cerebellar degeneration10.1
47paraneoplastic cerebellar degeneration10.1
48adenomatoid tumor10.1VIM
49glomus tumor10.1VIM
50syringoma10.1MUC1, S100B

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Carcinoma:



Diseases related to lymphoepithelioma-like carcinoma

Symptoms for Lymphoepithelioma-Like Carcinoma

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Drugs & Therapeutics for Lymphoepithelioma-Like Carcinoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Lymphoepithelioma-Like Carcinoma

Drug clinical trials:

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Search NIH Clinical Center for Lymphoepithelioma-Like Carcinoma

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Genetic Tests for Lymphoepithelioma-Like Carcinoma

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Anatomical Context for Lymphoepithelioma-Like Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Lymphoepithelioma-Like Carcinoma:

34
Lung, Skin, Cervix, Breast, Salivary gland, Colon, Ovary, Trachea, Thyroid, Thymus, T cells, B cells, Testes, Lymph node, Prostate, Kidney, Tonsil

Animal Models for Lymphoepithelioma-Like Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lymphoepithelioma-Like Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6PTPRC, TP53, MUC1, CDH1, EGFR
2MP:00030128.5PTPRC, TP53, MUC1, CDH1, EGFR
3MP:00053818.5PTPRC, TP53, MUC1, CDH1, EGFR
4MP:00107718.4TP53, MUC1, ACPP, S100B, CDH1, EGFR
5MP:00053847.8EGFR, CDH1, RPL22, VIM, TP53, PTPRC
6MP:00053807.6TP53, VIM, ALPP, CDH1, EGFR
7MP:00053977.6TNFRSF8, PTPRC, TP53, VIM, RPL22, EGFR
8MP:00053877.4TNFRSF8, PTPRC, TP53, VIM, RPL22, CDH1
9MP:00053787.1PTPRC, TP53, VIM, RPL22, ALPP, CDH1
10MP:00028736.9EGFR, PTPRC, TP53, MUC1, RPL22, ALPP

Publications for Lymphoepithelioma-Like Carcinoma

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53PubMed
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Articles related to Lymphoepithelioma-Like Carcinoma:

(show top 50)    (show all 227)
idTitleAuthorsYear
1
Lymphoepithelioma-like Carcinoma of the Endometrium: Immunophenotypic Characterization of a Rare Tumor With Microsatellite Instability Testing. (24300538)
2014
2
Lymphoepithelioma-like carcinoma of the colon. (23626513)
2013
3
Intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell. (23176314)
2013
4
Lymphoepithelioma-like carcinoma of the bladder: a case report and review of the literature. (23710410)
2013
5
Lymphoepithelioma-like carcinoma of the breast: cytological and histological features and review of the literature. (22236751)
2012
6
Lymphoepithelioma-like carcinoma of the colon. (22295155)
2012
7
Lymphoepithelioma-like carcinoma in a patient with mycosis fungoides. (22527441)
2012
8
Lymphoepithelioma-like carcinoma of the skin treated with wide local excision and chemoradiation therapy: a case report and review of the literature. (23133769)
2012
9
Primary pulmonary lymphoepithelioma-like carcinoma: fifty-two patients with long-term follow-up. (22359203)
2012
10
Lymphoepithelioma-like carcinoma of the ovary. (20444729)
2011
11
Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature. (20952226)
2011
12
Cutaneous lymphoepithelioma-like carcinoma: report of three cases. (22295745)
2011
13
Primary lymphoepithelioma-like carcinoma of the ureter. (20471568)
2010
14
Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma. (21080882)
2010
15
Cytology of lymphoepithelioma-like carcinoma of the urinary bladder. (19456843)
2009
16
Lymphoepithelioma-like carcinoma of the uterine cervix. (19238413)
2009
17
Pleomorphic lymphoepithelioma-like carcinoma of the urinary bladder. (19079656)
2009
18
Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung. (19704339)
2009
19
Lymphoepithelioma-like carcinoma of the prostate. (19269013)
2009
20
Lymphoepithelioma-like carcinoma of the skin mimicking a basal cell carcinoma. (19106051)
2009
21
Thymic lymphoepithelioma-like carcinoma mimicking primary tumor of the lung. (19618760)
2009
22
Lymphoepithelioma-like carcinoma of the urinary bladder in a cow associated with bovine papillomavirus type-2. (18675990)
2008
23
Lymphoepithelioma-like carcinoma arising in the scar from a previously excised basal cell carcinoma. (18201243)
2008
24
Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature. (17979492)
2007
25
Lymphoepithelioma-like carcinoma of the renal pelvis. (18036048)
2007
26
Primary lymphoepithelioma-like carcinoma of minor salivary gland: a case report with immunohistochemical and in situ hybridization studies. (16240326)
2006
27
Lymphoepithelioma-like carcinoma of the breast mimicking nodular sclerosing Hodgkin's lymphoma. (16174158)
2005
28
Lymphoepithelioma-like carcinoma of the breast: report of a case mimicking lymphoma. (15494940)
2004
29
Clinical role of circulating Epstein-Barr virus DNA as a tumor marker in lymphoepithelioma-like carcinoma of the lung. (15251971)
2004
30
Simultaneous EBV-positive lymphoepithelioma-like carcinoma and EBV-negative intestinal-type adenocarcinoma in a patient with Helicobacter pylori-associated chronic gastritis. (14983938)
2004
31
Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma. (12594554)
2003
32
Lymphoepithelioma-like carcinoma of the uterine cervix. (12456211)
2002
33
Lymphoepithelioma-like carcinoma of the breast. (12193205)
2002
34
Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. (11469686)
2001
35
Ectopic production and localization of beta-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix: a case report. (10782417)
2000
36
Lymphoepithelioma-like carcinoma of the uterine cervix: a case report studied by in situ hybridization and polymerase chain reaction for Epstein-Barr virus. (10782160)
2000
37
Case report: A case of lymphoepithelioma-like carcinoma of the oesophagus and review of the literature. (10385061)
1999
38
Case report of lymphoepithelioma-like carcinoma of the lung--lymphoid population consisting of cytotoxic T cells in resting state. (10605698)
1999
39
Lymphoepithelioma-like carcinoma of the colon: report of a case with histologic, immunohistochemical, and molecular studies for Epstein-Barr virus. (9678381)
1998
40
Expression of Epstein-Barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. (8600040)
1996
41
Lymphoepithelioma-like carcinoma of the skin. (8772027)
1996
42
Lymphoepithelioma-like carcinoma of the lung. Two cases diagnosed in Caucasian patients. (7778219)
1995
43
Epstein-Barr virus is detected in undifferentiated nasopharyngeal carcinoma but not in lymphoepithelioma-like carcinoma of the urinary bladder. (7590694)
1995
44
Lymphoepithelioma-like carcinoma of the lung. (8822122)
1995
45
Fine-needle aspiration cytologic diagnosis of lymphoepithelioma-like carcinoma of the lung. Report of two cases with immunohistochemical study. (7817941)
1995
46
Lymphoepithelioma-like carcinoma of the urinary bladder. (8172321)
1994
47
Lymphoepithelioma-like carcinoma of the skin: a light-microscopic and immunohistochemical study. (7699121)
1994
48
Lymphoepithelioma-like carcinoma of the lung. (2546459)
1989
49
Lymphoepithelioma-like carcinoma of the skin. (3237711)
1988
50
Epstein-Barr virus related lymphoepithelioma-like carcinoma of lung. (2826922)
1987

Variations for Lymphoepithelioma-Like Carcinoma

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Expression for genes affiliated with Lymphoepithelioma-Like Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoepithelioma-Like Carcinoma

Search GEO for disease gene expression data for Lymphoepithelioma-Like Carcinoma.

Pathways for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 54QIAGEN, 56Reactome, 13EMD Millipore, 58SinoBiological
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Pathways related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CDH1, EGFR
29.6CDH1, EGFR
39.6EGFR, CDH1
49.5TP53, CDH1
59.5TP53, EGFR
6
Show member pathways
Development ERBB family signaling61
Development GDNF family signaling61
9.3CDH1, MUC1, EGFR
79.3CGB, CDH1, TP53
89.2CDH1, TP53, VIM
99.1TP53, VIM, EGFR
109.1CDH1, TP53, EGFR
11
Show member pathways
Signal transduction PTEN pathway61
9.1TP53, CDH1, EGFR
12
Show member pathways
Signaling Pathways in Glioblastoma39
9.1EGFR, CDH1, TP53
139.1EGFR, CDH1, TP53
148.8TP53, MUC1, CDH1, EGFR
15
Show member pathways
8.8TNFRSF8, PTPRC, CDH1, EGFR
16
Show member pathways
7.9EGFR, MUC1, VIM, TP53, TNFRSF8, CDH1

Compounds for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Sources:
46Novoseek, 3BitterDB, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1eosin469.9VIM, S100B, MUC1
2s 100469.8MUC1, S100B, VIM
3reticulin469.8VIM, MUC1, S100B
4mucicarmine469.8S100B, MUC1, VIM
5[alcl]469.6TNFRSF8, PTPRC, MUC1
6aristolochic acid46 310.5TP53, VIM, CDH1
7tartrate469.4ACPP, VIM, ALPP
8sialic acid469.4PTPRC, S100B, MUC1, CDH1
9temozolomide46 1210.3VIM, EGFR, TP53
10dihydrotestosterone46 30 25 1212.3MUC1, CDH1, ACPP, VIM
11hyaluronic acid46 2510.2MUC1, CDH1, PTPRC, VIM
12crcs469.2TP53, CDH1, MUC1
13adriamycin469.2TP53, VIM, CDH1, MUC1
14formaldehyde46 2510.1PTPRC, S100B, MUC1, CDH1, VIM
15agar469.0MUC1, EGFR, CDH1, ACPP, VIM
16glycogen46 2510.0CDH1, S100B, MUC1, VIM, PTPRC
17thymidylate469.0VIM, TP53, EGFR, CDH1
18etoposide46 52 62 1211.9CGB, TP53, CDH1, S100B, VIM
19acth468.9ACPP, PTPRC, MUC1, S100B
20hydroxyapatite468.9VIM, ALPP, CDH1, S100B
21hematoxylin468.9ACPP, MUC1, PTPRC, S100B, VIM, CDH1
22cyclic amp46 259.8VIM, CGB, S100B, MUC1, CDH1
23paclitaxel46 52 1210.7S100B, VIM, TP53, EGFR, CDH1
24folate468.7VIM, CDH1, MUC1, ALPP
25dmso468.6MUC1, ALPP, PTPRC, VIM
26progestin468.5CDH1, ALPP, EGFR, MUC1, VIM
27butyrate468.4TP53, ALPP, VIM, MUC1, CDH1
28lactate468.4CGB, CDH1, VIM, ACPP, ALPP, S100B
29genistein46 30 62 3 25 1213.4CDH1, PTPRC, EGFR, VIM, ALPP
30b 723468.4S100B, CDH1, ALPP, VIM, MUC1, PTPRC
31aspartate468.3ALPP, S100B, CDH1, VIM, ACPP
32retinoid468.3CDH1, ALPP, VIM, TP53, EGFR
33sb 20358046 629.3TP53, EGFR, CDH1, ALPP, VIM
34alanine468.3VIM, ACPP, ALPP, S100B, CDH1, CGB
35dexamethasone46 52 30 1211.2PTPRC, VIM, MUC1, ALPP, CDH1, S100B
36creatinine468.1ALPP, S100B, CDH1, ACPP, CGB, VIM
37thymidine46 259.1ALPP, S100B, MUC1, TP53, TNFRSF8, ACPP
38cysteine468.0S100B, CGB, CDH1, VIM, MUC1, ALPP
39arginine468.0VIM, ACPP, ALPP, S100B, CDH1, TP53
40tamoxifen46 52 30 1211.0EGFR, TP53, VIM, ALPP, CDH1, MUC1
41heparin46 30 25 1211.0CDH1, VIM, PTPRC, RPL22, ALPP, S100B
42tyrosine467.9EGFR, S100B, CDH1, MUC1, TNFRSF8, PTPRC
43cisplatin46 52 62 1210.8MUC1, ACPP, CDH1, EGFR, CGB, ALPP
44retinoic acid46 258.6MUC1, ALPP, TP53, VIM, EGFR, S100B
45progesterone46 30 62 25 1211.6MUC1, VIM, ACPP, S100B, EGFR, CGB
46testosterone46 62 25 1210.3VIM, ACPP, CDH1, MUC1, CGB, PTPRC
47vegf467.1TP53, EGFR, CGB, ALPP, ACPP, S100B
48estrogen466.8CDH1, ALPP, S100B, ACPP, PTPRC, VIM
49paraffin466.6MUC1, VIM, TNFRSF8, PTPRC, EGFR, CDH1
50serine466.6ACPP, CDH1, S100B, ALPP, MUC1, VIM

GO Terms for genes affiliated with Lymphoepithelioma-Like Carcinoma

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17Gene Ontology
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Cellular components related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.4MUC1, ALPP, CDH1, EGFR
2extracellular vesicular exosomeGO:0700628.1RPL22, ACPP, MUC1, VIM, PTPRC, TNFRSF8
3plasma membraneGO:0058867.3PTPRC, VIM, ACPP, ALPP, CDH1, EGFR
4cytoplasmGO:0057376.6TNFRSF8, TP53, VIM, MUC1, RPL22, S100B

Biological processes related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.7MUC1, TP53
2learning or memoryGO:0076119.4EGFR, S100B
3dephosphorylationGO:0163119.1ALPP, ACPP, PTPRC
4positive regulation of apoptotic processGO:0430659.1S100B, TP53, TNFRSF8
5apoptotic processGO:0069158.8TP53, VIM, CDH1, CGB

Molecular functions related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.1EGFR, CDH1, VIM
2protein phosphatase bindingGO:0199038.8CDH1, EGFR, TP53
3identical protein bindingGO:0428028.5TP53, VIM, ACPP, S100B, EGFR
4protein bindingGO:0055157.5EGFR, CDH1, ACPP, PTPRC, S100B, VIM

Products for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Sources for Lymphoepithelioma-Like Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet