MCID: LYM006
MIFTS: 34

Lymphoepithelioma-Like Carcinoma malady

Immune, Cancer categories

Summaries for Lymphoepithelioma-Like Carcinoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of... more...

MalaCards: Lymphoepithelioma-Like Carcinoma, also known as lymphoepithelial carcinoma, is related to bladder carcinoma and thymic carcinoma. An important gene associated with Lymphoepithelioma-Like Carcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Colorectal Cancer Metastasis and Apoptosis Pathway. The compounds estrogen and aristolochic acid have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and integument.

Disease Ontology:8 A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells.

Aliases & Classifications for Lymphoepithelioma-Like Carcinoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Immune


Aliases & Descriptions:

lymphoepithelioma-like carcinoma 8
lymphoepithelial carcinoma 8 61
nasopharyngeal type undifferentiated carcinoma 8


External Ids:

Disease Ontology8 DOID:5660
SNOMED-CT57 7300000
NCIt40 C4107

Related Diseases for Lymphoepithelioma-Like Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphoepithelioma-Like Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma31.3TP53, CDH1, CGB
2thymic carcinoma30.6ALPP, MUC1
3thymoma30.5PTPRC
4ulcerative colitis30.5TP53
5adenocarcinoma30.4VIM, EGFR, CGB, MUC1, CDH1, ACPP
6squamous cell carcinoma30.3VIM, EGFR, CGB, MUC1, CDH1, ACPP
7mycosis fungoides30.2TNFRSF8
8arthritis30.2ACPP, ALPP
9spindle cell carcinoma30.2VIM, MUC1
10anaplastic large cell lymphoma30.2TNFRSF8, MUC1, PTPRC
11colorectal cancer30.2EGFR, CDH1, BCL2, TP53
12sinonasal undifferentiated carcinoma10.4
13eye carcinoma10.4
14infiltrating bladder lymphoepithelioma-like carcinoma10.4
15eyelid carcinoma10.4
16cervical lymphoepithelioma-like carcinoma10.4
17trachea carcinoma10.4
18lymphoepithelioma-like thymic carcinoma10.3
19breast lymphoma10.3
20large cell carcinoma10.3
21basal cell carcinoma10.3
22keratinizing squamous cell carcinoma10.3
23papillary carcinoma10.2
24sweat gland carcinoma10.2
25pleomorphic carcinoma10.2
26gastric lymphoma10.2
27silicosis10.2
28n syndrome10.2
29adenosquamous carcinoma10.2
30bile duct carcinoma10.2
31erythema elevatum diutinum10.2
32pulmonary sequestration10.2
33lymphangitis10.1
34cerebellar degeneration10.1
35paraneoplastic cerebellar degeneration10.1
36gemistocytic astrocytoma10.0S100B
37acute leukemia10.0PTPRC
38prostatitis10.0ACPP
39multiple sclerosis10.0PTPRC
40paraganglioma10.0S100B
41cystadenocarcinoma10.0MUC1
42asthma10.0TNFRSF8
43infertility10.0CGB
44hidradenoma10.0MUC1
45pneumonia10.0MUC1
46sertoli-leydig cell tumor10.0MUC1
47graves' disease10.0PTPRC
48pilocytic astrocytoma10.0S100B
49adenomatoid tumor10.0VIM
50neural tube defects10.0CGB

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Carcinoma:



Diseases related to lymphoepithelioma-like carcinoma

Clinical Features for Lymphoepithelioma-Like Carcinoma

Drugs & Therapeutics for Lymphoepithelioma-Like Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Lymphoepithelioma-Like Carcinoma

Drug clinical trials:

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Search NIH Clinical Center for Lymphoepithelioma-Like Carcinoma

Search CenterWatch for Lymphoepithelioma-Like Carcinoma

Genetic Tests for Lymphoepithelioma-Like Carcinoma

Anatomical Context for Lymphoepithelioma-Like Carcinoma

Animal Models for Lymphoepithelioma-Like Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lymphoepithelioma-Like Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5PTPRC, CDH1, EGFR
2MP:00107718.4S100B, CDH1, ACPP, BCL2, TP53
3MP:00053818.3MUC1, CDH1, PTPRC, BCL2, TP53, EGFR
4MP:00028737.2TP53, RPL22, S100B, EGFR, MUC1, CDH1
5MP:00053876.6RPL22, VIM, TNFRSF8, EGFR, CDH1, PTPRC

Publications for Lymphoepithelioma-Like Carcinoma

Genetic Variations for Lymphoepithelioma-Like Carcinoma

Expression for genes affiliated with Lymphoepithelioma-Like Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphoepithelioma-Like Carcinoma

Search GEO for disease gene expression data for Lymphoepithelioma-Like Carcinoma.

Pathways for genes affiliated with Lymphoepithelioma-Like Carcinoma

Sources:
52QIAGEN, 60Tocris Bioscience, 30KEGG, 56SinoBiological, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1EGFR
210.1BCL2
3
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10.0TP53
4
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9.9TNFRSF8
59.8CDH1, EGFR
69.6TP53, BCL2
7
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9.6TP53, BCL2
89.4CGB, CDH1, TP53
9
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9.3PTPRC, BCL2, TP53
109.3TP53, EGFR, VIM
119.2EGFR, BCL2, TP53
12
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9.0BCL2, CDH1, MUC1, EGFR
139.0TP53, CDH1, MUC1, EGFR
148.9TP53, BCL2, EGFR, VIM
15
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8.9TP53, BCL2, CDH1, EGFR
16
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8.9TP53, BCL2, CDH1, EGFR
178.9EGFR, CDH1, BCL2, TP53
188.9EGFR, CDH1, BCL2, TP53
19
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8.5TNFRSF8, EGFR, CDH1, PTPRC, BCL2
20
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7.6VIM, TNFRSF8, EGFR, MUC1, CDH1, BCL2

Compounds for genes affiliated with Lymphoepithelioma-Like Carcinoma

Sources:
45Novoseek, 2BitterDB, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1estrogen4510.4ACPP
2aristolochic acid45 211.4VIM
3vincristine45 50 1112.4VIM
4glycogen45 2411.3PTPRC
5cycloheximide4510.3ALPP
6eosin4510.0VIM, S100B, MUC1
7s 100459.9MUC1, VIM, S100B
8sialic acid459.9PTPRC
9reticulin459.9MUC1, S100B, VIM
10adriamycin459.8BCL2, VIM, MUC1
11mucicarmine459.8VIM, S100B, MUC1
12tamoxifen45 50 29 1112.7EGFR, CDH1, ALPP
13temozolomide45 1110.5VIM, EGFR, TP53
14[alcl]459.5PTPRC, MUC1, TNFRSF8
15tartrate459.4ACPP, ALPP, VIM
16hydroxyapatite459.4VIM, S100B, CDH1, ALPP
17formaldehyde45 2410.4VIM, CDH1, S100B, MUC1, PTPRC
18suberoylanilide hydroxamic acid459.3BCL2, CDH1, EGFR, TP53
19vinblastine45 50 1111.3TP53, BCL2, CDH1, VIM
20creatinine459.3ACPP, CGB, ALPP, CDH1
21serine459.2CDH1, S100B, ACPP, ALPP
22taxane459.2EGFR, BCL2, TP53
23cytarabine45 50 1111.2VIM, MUC1, BCL2, TP53
24gemcitabine45 50 1111.2EGFR, BCL2, MUC1, TP53
25hematoxylin459.2ACPP, CDH1, VIM, S100B, PTPRC
26heparin45 29 11 2412.1PTPRC, CDH1, S100B, RPL22
27progestin459.0MUC1, EGFR, VIM, ALPP, CDH1
28dexamethasone45 50 29 1112.0BCL2, CDH1, S100B, PTPRC, ALPP
29paclitaxel45 50 1111.0BCL2, CDH1, EGFR, S100B, TP53
30thymidylate459.0TP53, EGFR, CDH1, BCL2, VIM
31agar459.0MUC1, EGFR, VIM, ACPP, CDH1
325fluorouracil458.9BCL2, TP53, CDH1, MUC1, EGFR
33n acetylcysteine458.9PTPRC, BCL2, EGFR, CDH1, TP53
34mg 13245 609.9TP53, CDH1, EGFR, BCL2
35b 723458.9ALPP, PTPRC, CDH1, MUC1, S100B, VIM
36etoposide45 50 60 1111.8S100B, CGB, VIM, CDH1, TP53, BCL2
37docetaxel45 50 60 1111.8BCL2, TP53, CDH1, EGFR
38doxorubicin45 50 1110.7CDH1, BCL2, TP53, VIM, EGFR
39genistein45 29 60 2 11 2413.6EGFR, PTPRC, CDH1, VIM, BCL2, ALPP
40lactate458.6CDH1, CGB, S100B, ACPP, ALPP, VIM
41retinoid458.5BCL2, ALPP, TP53, EGFR, VIM, CDH1
42cysteine458.5PTPRC, VIM, S100B, CGB, ALPP, CDH1
43sb 20358045 609.5BCL2, VIM, TP53, ALPP, CDH1, EGFR
44thymidine45 249.1TNFRSF8, TP53, ALPP, ACPP, MUC1, S100B
45retinoic acid45 248.9TP53, S100B, ALPP, VIM, BCL2, CDH1
46cisplatin45 50 60 1110.7CGB, MUC1, EGFR, CDH1, ACPP, BCL2
47testosterone45 60 11 2410.7MUC1, PTPRC, ACPP, VIM, S100B, EGFR
48progesterone45 60 29 11 2411.4EGFR, VIM, S100B, CGB, MUC1, TP53
49vegf457.1TP53, VIM, ALPP, BCL2, ACPP, CDH1
50paraffin456.5TP53, TNFRSF8, S100B, VIM, ACPP, MUC1

GO Terms for genes affiliated with Lymphoepithelioma-Like Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.5TP53, BCL2, CDH1, MUC1, EGFR, TNFRSF8

Biological processes related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell lineage commitmentGO:0023269.7TP53, BCL2
2B cell proliferationGO:0421009.7PTPRC, BCL2
3digestive tract morphogenesisGO:0485469.7BCL2, EGFR
4regulation of mitochondrial membrane permeabilityGO:0469029.6BCL2, TP53
5DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4TP53, MUC1
6cell-cell adhesionGO:0163379.4BCL2, CDH1, EGFR

Molecular functions related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.6TP53, BCL2
2identical protein bindingGO:0428027.8TP53, BCL2, ACPP, EGFR, S100B, VIM

Products for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Sources for Lymphoepithelioma-Like Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet