MCID: LYM006
MIFTS: 47

Lymphoepithelioma-Like Carcinoma malady

Immune diseases, Cancer diseases categories

Summaries for Lymphoepithelioma-Like Carcinoma

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Wikipedia:63 Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of... more...

MalaCards based summary: Lymphoepithelioma-Like Carcinoma, also known as lymphoepithelial carcinoma, is related to histiocytosis and anaplastic large cell lymphoma. An important gene associated with Lymphoepithelioma-Like Carcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are a6b1 and a6b4 Integrin signaling and E-cadherin signaling in keratinocytes. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and breast, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Disease Ontology:9 A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells.

Aliases & Classifications for Lymphoepithelioma-Like Carcinoma

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Lymphoepithelioma-Like Carcinoma, Aliases & Descriptions:

Name: Lymphoepithelioma-Like Carcinoma 9
Lymphoepithelial Carcinoma 9 60
 
Nasopharyngeal Type Undifferentiated Carcinoma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:5660
SNOMED-CT55 7300000
NCIt38 C4107

Related Diseases for Lymphoepithelioma-Like Carcinoma

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Diseases related to Lymphoepithelioma-Like Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis30.8ACPP, S100B
2anaplastic large cell lymphoma30.6TNFRSF8, PTPRC, MUC1
3breast cancer30.5TP53, CDH1
4adenosquamous carcinoma30.5EGFR, MUC1
5gastrointestinal stromal tumor30.4S100B, VIM
6cholangiocarcinoma30.3TP53, MUC1, ALPP, CDH1, CGB
7nasopharyngeal carcinoma30.0EGFR, CDH1, TP53, TNFRSF8
8lung cancer30.0TP53, EGFR, CGB
9colorectal cancer29.4TP53, MUC1, ALPP, CDH1, EGFR, CGB
10adenocarcinoma29.4CGB, EGFR, CDH1, ACPP, MUC1, VIM
11papilloma10.6
12giant cell tumor10.6ACPP
13hidradenoma10.6MUC1
14superior vena cava syndrome10.6CGB
15gemistocytic astrocytoma10.5S100B
16eccrine porocarcinoma10.5MUC1
17infiltrating bladder lymphoepithelioma-like carcinoma10.5
18cervical lymphoepithelioma-like carcinoma10.5
19cystadenocarcinoma10.5MUC1
20rosai-dorfman disease10.5S100B
21sinonasal undifferentiated carcinoma10.5
22adenomatoid tumor10.5VIM
23glomus tumor10.5VIM
24nasopharyngitis10.5
25thyroiditis10.5
26syringoma10.4MUC1, S100B
27fibrous meningioma10.4S100B, MUC1
28choroid plexus papilloma10.4MUC1, S100B
29anaplastic ependymoma10.4MUC1, S100B
30ulcerative colitis10.4
31lymphoepithelioma-like thymic carcinoma10.4
32basal cell carcinoma10.4
33colitis10.4
34intrahepatic cholangiocarcinoma10.4
35thymoma10.4
36germinoma10.4CGB, ALPP
37hemangioblastoma10.3MUC1, S100B
38giant cell glioblastoma10.3EGFR
39thymic carcinoma10.3MUC1, ALPP
40clear cell ependymoma10.3MUC1, VIM
41mesenchymal chondrosarcoma10.3VIM, MUC1
42benign breast phyllodes tumor10.3VIM, ACPP
43malignant fibroxanthoma10.3TP53, ACPP
44adrenal hyperplasia, congenital, due to 11-beta-hydroxylase deficiency10.3ACPP, ALPP
45spindle cell carcinoma10.3VIM, MUC1
46epithelioid sarcoma10.3MUC1, VIM
47gestational trophoblastic neoplasm10.3ALPP, CGB
48secretory meningioma10.3VIM, MUC1
49myoepithelioma10.3VIM, S100B
50granular cell tumor10.3VIM, S100B

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Carcinoma:



Diseases related to lymphoepithelioma-like carcinoma

Symptoms for Lymphoepithelioma-Like Carcinoma

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Drugs & Therapeutics for Lymphoepithelioma-Like Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Lymphoepithelioma-Like Carcinoma

Search NIH Clinical Center for Lymphoepithelioma-Like Carcinoma

Genetic Tests for Lymphoepithelioma-Like Carcinoma

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Anatomical Context for Lymphoepithelioma-Like Carcinoma

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MalaCards organs/tissues related to Lymphoepithelioma-Like Carcinoma:

31
Skin, Lung, Breast, Cervix, Salivary gland, Colon, Thyroid, Ovary, Trachea, Lymph node, Thymus, Kidney, Prostate, Testes, Tonsil, T cells, B cells

Animal Models for Lymphoepithelioma-Like Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Lymphoepithelioma-Like Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6MUC1, TP53, CDH1, EGFR, PTPRC
2MP:00030128.5TP53, CDH1, EGFR, PTPRC, MUC1
3MP:00053818.5CDH1, EGFR, TP53, MUC1, PTPRC
4MP:00107718.4ACPP, EGFR, CDH1, S100B, MUC1, TP53
5MP:00053847.8PTPRC, EGFR, VIM, RPL22, CDH1, TP53
6MP:00053807.6TP53, VIM, EGFR, CDH1, ALPP
7MP:00053977.6TP53, VIM, TNFRSF8, RPL22, EGFR, PTPRC
8MP:00053877.4VIM, RPL22, PTPRC, EGFR, CDH1, TP53
9MP:00053787.1EGFR, ALPP, RPL22, VIM, TP53, PTPRC
10MP:00028736.9EGFR, RPL22, ALPP, S100B, CDH1, TP53

Publications for Lymphoepithelioma-Like Carcinoma

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Articles related to Lymphoepithelioma-Like Carcinoma:

(show top 50)    (show all 253)
idTitleAuthorsYear
1
Lymphoepithelioma-like carcinoma: A distinct type of gastric cancer. (25592274)
2015
2
PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: A potential rationale for immunotherapy. (25862146)
2015
3
Lymphoepithelioma-like Carcinoma of the Endometrium: Immunophenotypic Characterization of a Rare Tumor With Microsatellite Instability Testing. (24300538)
2014
4
Lymphoepithelioma-like carcinoma of the breast: Cytological, histological, and immunohistochemical characteristics. (24610805)
2014
5
Lymphoepithelioma-like carcinoma of the urinary bladder: a case report and review of the literature. (25367311)
2014
6
Intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell. (23176314)
2013
7
Lymphoepithelioma-like carcinoma of the breast: cytological and histological features and review of the literature. (22236751)
2012
8
Lymphoepithelioma-like carcinoma of the colon. (22295155)
2012
9
Lymphoepithelioma-like carcinoma in a patient with mycosis fungoides. (22527441)
2012
10
Lymphoepithelioma-like carcinoma of the skin treated with wide local excision and chemoradiation therapy: a case report and review of the literature. (23133769)
2012
11
Primary pulmonary lymphoepithelioma-like carcinoma: fifty-two patients with long-term follow-up. (22359203)
2012
12
Lymphoepithelioma-like carcinoma of the ovary. (20444729)
2011
13
Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature. (20952226)
2011
14
Cutaneous lymphoepithelioma-like carcinoma: report of three cases. (22295745)
2011
15
Primary lymphoepithelioma-like carcinoma of the ureter. (20471568)
2010
16
Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma. (21080882)
2010
17
Cytology of lymphoepithelioma-like carcinoma of the urinary bladder. (19456843)
2009
18
Lymphoepithelioma-like carcinoma of the uterine cervix. (19238413)
2009
19
Pleomorphic lymphoepithelioma-like carcinoma of the urinary bladder. (19079656)
2009
20
Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung. (19704339)
2009
21
Lymphoepithelioma-like carcinoma of the prostate. (19269013)
2009
22
Lymphoepithelioma-like carcinoma of the skin mimicking a basal cell carcinoma. (19106051)
2009
23
Thymic lymphoepithelioma-like carcinoma mimicking primary tumor of the lung. (19618760)
2009
24
Lymphoepithelioma-like carcinoma of the urinary bladder in a cow associated with bovine papillomavirus type-2. (18675990)
2008
25
Lymphoepithelioma-like carcinoma arising in the scar from a previously excised basal cell carcinoma. (18201243)
2008
26
Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature. (17979492)
2007
27
Primary lymphoepithelioma-like carcinoma of minor salivary gland: a case report with immunohistochemical and in situ hybridization studies. (16240326)
2006
28
Lymphoepithelioma-like carcinoma of the breast mimicking nodular sclerosing Hodgkin's lymphoma. (16174158)
2005
29
Lymphoepithelioma-like carcinoma of the breast: report of a case mimicking lymphoma. (15494940)
2004
30
Clinical role of circulating Epstein-Barr virus DNA as a tumor marker in lymphoepithelioma-like carcinoma of the lung. (15251971)
2004
31
Simultaneous EBV-positive lymphoepithelioma-like carcinoma and EBV-negative intestinal-type adenocarcinoma in a patient with Helicobacter pylori-associated chronic gastritis. (14983938)
2004
32
Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma. (12594554)
2003
33
Lymphoepithelioma-like carcinoma of the uterine cervix. (12456211)
2002
34
Lymphoepithelioma-like carcinoma of the breast. (12193205)
2002
35
Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. (11469686)
2001
36
Ectopic production and localization of beta-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix: a case report. (10782417)
2000
37
Lymphoepithelioma-like carcinoma of the uterine cervix: a case report studied by in situ hybridization and polymerase chain reaction for Epstein-Barr virus. (10782160)
2000
38
Case report: A case of lymphoepithelioma-like carcinoma of the oesophagus and review of the literature. (10385061)
1999
39
Case report of lymphoepithelioma-like carcinoma of the lung--lymphoid population consisting of cytotoxic T cells in resting state. (10605698)
1999
40
Lymphoepithelioma-like carcinoma of the colon: report of a case with histologic, immunohistochemical, and molecular studies for Epstein-Barr virus. (9678381)
1998
41
Expression of Epstein-Barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. (8600040)
1996
42
Lymphoepithelioma-like carcinoma of the lung. Two cases diagnosed in Caucasian patients. (7778219)
1995
43
Epstein-Barr virus is detected in undifferentiated nasopharyngeal carcinoma but not in lymphoepithelioma-like carcinoma of the urinary bladder. (7590694)
1995
44
Lymphoepithelioma-like carcinoma of the lung. (8822122)
1995
45
Fine-needle aspiration cytologic diagnosis of lymphoepithelioma-like carcinoma of the lung. Report of two cases with immunohistochemical study. (7817941)
1995
46
Lymphoepithelioma-like carcinoma of the urinary bladder. (8172321)
1994
47
Lymphoepithelioma-like carcinoma of the skin: a light-microscopic and immunohistochemical study. (7699121)
1994
48
Lymphoepithelioma-like carcinoma of the lung. (2546459)
1989
49
Lymphoepithelioma-like carcinoma of the skin. (3237711)
1988
50
Epstein-Barr virus related lymphoepithelioma-like carcinoma of lung. (2826922)
1987

Variations for Lymphoepithelioma-Like Carcinoma

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Expression for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Search GEO for disease gene expression data for Lymphoepithelioma-Like Carcinoma.

Pathways for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Compounds for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Compounds related to Lymphoepithelioma-Like Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1eosin439.9VIM, S100B, MUC1
2s 100439.8MUC1, S100B, VIM
3reticulin439.8VIM, MUC1, S100B
4mucicarmine439.8S100B, MUC1, VIM
5[alcl]439.6TNFRSF8, PTPRC, MUC1
6aristolochic acid43 210.5TP53, VIM, CDH1
7tartrate439.4ACPP, VIM, ALPP
8sialic acid439.4PTPRC, S100B, MUC1, CDH1
9temozolomide43 1210.3VIM, EGFR, TP53
10dihydrotestosterone43 28 24 1212.3MUC1, CDH1, ACPP, VIM
11hyaluronic acid43 2410.2MUC1, CDH1, PTPRC, VIM
12crcs439.2TP53, CDH1, MUC1
13adriamycin439.2TP53, VIM, CDH1, MUC1
14formaldehyde43 2410.1PTPRC, S100B, MUC1, CDH1, VIM
15agar439.0MUC1, EGFR, CDH1, ACPP, VIM
16glycogen43 2410.0CDH1, S100B, MUC1, VIM, PTPRC
17thymidylate439.0VIM, TP53, EGFR, CDH1
18etoposide43 49 59 1211.9CGB, TP53, CDH1, S100B, VIM
19acth438.9ACPP, PTPRC, MUC1, S100B
20hydroxyapatite438.9VIM, ALPP, CDH1, S100B
21hematoxylin438.9ACPP, MUC1, PTPRC, S100B, VIM, CDH1
22cyclic amp43 249.8VIM, CGB, S100B, MUC1, CDH1
23paclitaxel43 49 1210.7S100B, VIM, TP53, EGFR, CDH1
24folate438.7VIM, CDH1, MUC1, ALPP
25dmso438.6MUC1, ALPP, PTPRC, VIM
26progestin438.5CDH1, ALPP, EGFR, MUC1, VIM
27butyrate438.4TP53, ALPP, VIM, MUC1, CDH1
28lactate438.4CGB, CDH1, VIM, ACPP, ALPP, S100B
29genistein43 28 59 2 24 1213.4CDH1, PTPRC, EGFR, VIM, ALPP
30b 723438.4S100B, CDH1, ALPP, VIM, MUC1, PTPRC
31aspartate438.3ALPP, S100B, CDH1, VIM, ACPP
32retinoid438.3CDH1, ALPP, VIM, TP53, EGFR
33sb 20358043 599.3TP53, EGFR, CDH1, ALPP, VIM
34alanine438.3VIM, ACPP, ALPP, S100B, CDH1, CGB
35dexamethasone43 49 28 1211.2PTPRC, VIM, MUC1, ALPP, CDH1, S100B
36creatinine438.1ALPP, S100B, CDH1, ACPP, CGB, VIM
37thymidine43 249.1ALPP, S100B, MUC1, TP53, TNFRSF8, ACPP
38cysteine438.0S100B, CGB, CDH1, VIM, MUC1, ALPP
39arginine438.0VIM, ACPP, ALPP, S100B, CDH1, TP53
40tamoxifen43 49 28 1211.0EGFR, TP53, VIM, ALPP, CDH1, MUC1
41heparin43 28 24 1211.0CDH1, VIM, PTPRC, RPL22, ALPP, S100B
42tyrosine437.9EGFR, S100B, CDH1, MUC1, TNFRSF8, PTPRC
43cisplatin43 49 59 1210.8MUC1, ACPP, CDH1, EGFR, CGB, ALPP
44retinoic acid43 248.6MUC1, ALPP, TP53, VIM, EGFR, S100B
45progesterone43 28 59 24 1211.6MUC1, VIM, ACPP, S100B, EGFR, CGB
46testosterone43 59 24 1210.3VIM, ACPP, CDH1, MUC1, CGB, PTPRC
47vegf437.1TP53, EGFR, CGB, ALPP, ACPP, S100B
48estrogen436.8CDH1, ALPP, S100B, ACPP, PTPRC, VIM
49paraffin436.6MUC1, VIM, TNFRSF8, PTPRC, EGFR, CDH1
50serine436.6ACPP, CDH1, S100B, ALPP, MUC1, VIM

GO Terms for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Cellular components related to Lymphoepithelioma-Like Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.4MUC1, ALPP, CDH1, EGFR
2extracellular vesicular exosomeGO:00700628.1TNFRSF8, RPL22, ACPP, MUC1, VIM, PTPRC
3plasma membraneGO:00058867.3ACPP, EGFR, CDH1, TNFRSF8, PTPRC, ALPP
4cytoplasmGO:00057376.6EGFR, TP53, CDH1, S100B, RPL22, MUC1

Biological processes related to Lymphoepithelioma-Like Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00069789.7MUC1, TP53
2learning or memoryGO:00076119.4S100B, EGFR
3dephosphorylationGO:00163119.1PTPRC, ACPP, ALPP
4positive regulation of apoptotic processGO:00430659.1S100B, TP53, TNFRSF8
5apoptotic processGO:00069158.8CGB, CDH1, VIM, TP53

Molecular functions related to Lymphoepithelioma-Like Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:00019489.1EGFR, CDH1, VIM
2protein phosphatase bindingGO:00199038.8CDH1, EGFR, TP53
3identical protein bindingGO:00428028.5TP53, VIM, ACPP, S100B, EGFR
4protein bindingGO:00055157.5EGFR, CDH1, ACPP, PTPRC, S100B, VIM

Products for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Sources for Lymphoepithelioma-Like Carcinoma

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3CDC
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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35MGI
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