MCID: LYM006
MIFTS: 53

Lymphoepithelioma-Like Carcinoma malady

Immune diseases, Cancer diseases categories

Summaries for Lymphoepithelioma-Like Carcinoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of... more...

MalaCards: Lymphoepithelioma-Like Carcinoma, also known as lymphoepithelial carcinoma, is related to bladder carcinoma and papilloma. An important gene associated with Lymphoepithelioma-Like Carcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are Colorectal Cancer Metastasis and Apoptosis Pathway. The compounds estrogen and aristolochic acid have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and cervix, and related mouse phenotypes are tumorigenesis and integument.

Disease Ontology:8 A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells.

Aliases & Classifications for Lymphoepithelioma-Like Carcinoma

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphoepithelioma-like carcinoma 8
lymphoepithelial carcinoma 8 60
nasopharyngeal type undifferentiated carcinoma 8


External Ids:

Disease Ontology8 DOID:5660
SNOMED-CT56 7300000
NCIt39 C4107

Related Diseases for Lymphoepithelioma-Like Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Lymphoepithelioma-Like Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1bladder carcinoma31.2TP53, CDH1, CGB
2papilloma30.7TP53
3thymoma30.4PTPRC
4ulcerative colitis30.4TP53
5cholangiocarcinoma30.4CGB, MUC1, CDH1, ALPP, TP53
6adenocarcinoma30.4VIM, EGFR, CGB, MUC1, CDH1, ACPP
7squamous cell carcinoma30.3VIM, EGFR, CGB, MUC1, CDH1, ACPP
8prostatitis30.2ACPP
9hepatitis30.2ALPP
10gastritis30.2TP53
11histiocytosis30.2ACPP, S100B
12rheumatoid arthritis30.2PTPRC, TNFRSF8
13mycosis fungoides30.2TNFRSF8
14arthritis30.2ACPP, ALPP
15spindle cell carcinoma30.2VIM, MUC1
16anaplastic large cell lymphoma30.2TNFRSF8, MUC1, PTPRC
17hodgkin's lymphoma30.2TNFRSF8, PTPRC, BCL2
18lung cancer30.2TP53, BCL2, CGB, EGFR
19hepatocellular carcinoma30.2CDH1, BCL2, ALPP, TP53
20colorectal cancer30.2EGFR, CDH1, BCL2, TP53
21colon cancer30.2EGFR, CDH1, BCL2, TP53
22breast cancer30.1TNFRSF8, EGFR, CGB, MUC1, CDH1, ACPP
23lymphoepithelioma-like thymic carcinoma10.5
24in situ carcinoma10.5
25renal pelvis carcinoma10.5
26cervical lymphoepithelioma-like carcinoma10.5
27infiltrating bladder lymphoepithelioma-like carcinoma10.4
28nasopharyngitis10.4
29thymic carcinoma10.4
30breast lymphoma10.3
31large cell carcinoma10.3
32basal cell carcinoma10.3
33thyroiditis10.3
34keratinizing squamous cell carcinoma10.2
35papillary carcinoma10.2
36stomach carcinoma in situ10.2
37pleomorphic carcinoma10.2
38gastric lymphoma10.2
39silicosis10.2
40tonsillitis10.2
41adenosquamous carcinoma10.2
42hepatitis a10.2
43bile duct carcinoma10.2
44cervicitis10.2
45intrahepatic cholangiocarcinoma10.2
46langerhans-cell histiocytosis10.2
47middle ear carcinoma10.2
48nephrotic syndrome10.2
49papillary thyroid carcinoma10.2
50lymphangitis10.1

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Carcinoma:



Diseases related to lymphoepithelioma-like carcinoma

Clinical Features for Lymphoepithelioma-Like Carcinoma

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Drugs & Therapeutics for Lymphoepithelioma-Like Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lymphoepithelioma-Like Carcinoma

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Anatomical Context for Lymphoepithelioma-Like Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Lymphoepithelioma-Like Carcinoma:

32
Lung, Skin, Cervix, Breast, Salivary gland, Colon, Ovary, Trachea, Thyroid, Lymph node, T cells, B cells, Thymus, Prostate, Kidney, Tonsil, Testes

Animal Models for Lymphoepithelioma-Like Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphoepithelioma-Like Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5PTPRC, CDH1, EGFR
2MP:00107718.4S100B, CDH1, ACPP, BCL2, TP53
3MP:00053818.3MUC1, CDH1, PTPRC, BCL2, TP53, EGFR
4MP:00028737.2TP53, RPL22, S100B, EGFR, MUC1, CDH1
5MP:00053876.6RPL22, VIM, TNFRSF8, EGFR, CDH1, PTPRC

Publications for Lymphoepithelioma-Like Carcinoma

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50PubMed
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Articles related to Lymphoepithelioma-Like Carcinoma:

(show top 50)    (show all 235)
idTitleAuthorsYear
1
Lymphoepithelioma-like carcinoma of the colon. (23626513)
2013
2
Primary lymphoepithelioma-like carcinoma of ocular adnexa: clinicopathologic features and treatment. (23559878)
2013
3
Primary lymphoepithelioma-like carcinoma of salivary gland: Sixty-nine cases with long-term follow-up. (23966284)
2013
4
Non-Epstein-Barr virus associated lymphoepithelioma-like carcinoma of the esophagogastric junction with microsatellite instability, K-ras wild type. (23332353)
2013
5
Lymphoepithelioma-like carcinoma of the breast: cytological and histological features and review of the literature. (22236751)
2012
6
Primary pulmonary lymphoepithelioma-like carcinoma: fifty-two patients with long-term follow-up. (22359203)
2012
7
Lymphoepithelioma-like carcinoma of the urinary bladder: A case report and review of systemic treatment options. (22346102)
2012
8
Lymphoepithelioma-like carcinoma of ureter-a rare case report and review of the literature. (22974672)
2012
9
Lymphoepithelioma-like carcinoma of the ovary. (20444729)
2011
10
Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature. (20952226)
2011
11
Primary lymphoepithelioma-like carcinoma of the ureter. (21396867)
2011
12
Lymphoepithelioma-like carcinoma involving the lacrimal gland and infiltrating the eyelids. (21140371)
2011
13
Lymphoepithelioma-like carcinoma of the urinary bladder: clinicopathologic, immunohistochemical, and molecular features. (21383609)
2011
14
Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma. (21080882)
2010
15
Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature. (20736767)
2010
16
Double primary-Lymphoepithelioma-like carcinoma of the parotid and papillary carcinoma of the thyroid. (21131769)
2010
17
Erythema elevatum diutinum as a paraneoplastic syndrome in a patient with pulmonary lymphoepithelioma-like carcinoma. (18571759)
2009
18
Lymphoepithelioma-like carcinoma of the urinary bladder: report of a rare case. (19847088)
2009
19
Does Epstein-Barr virus play a role in lymphoepithelioma-like carcinoma of the uterine cervix? (19620947)
2009
20
Epstein-barr virus-associated lymphoepithelioma-like carcinoma of mandible. (18457481)
2009
21
Absence of Epstein-Barr virus, human papillomavirus, and simian virus 40 in patients of central european origin with lymphoepithelioma-like carcinoma of the skin. (17667169)
2007
22
Computed tomography characteristics of primary pulmonary lymphoepithelioma-like carcinoma. (17875600)
2007
23
Lymphoepithelioma-like carcinoma of salivary glands: treatment results and failure patterns. (16421405)
2006
24
EBER expression of pure urinary bladder lymphoepithelioma-like carcinoma in two unique Asian patients. (15812220)
2005
25
Lymphoepithelioma-like carcinoma of the uterine cervix: absence of Epstein-Barr virus, but presence of a multiple human papillomavirus infection. (15863191)
2005
26
Lymphoepithelioma-like carcinoma of the eyelid: a report of two cases. (16113388)
2005
27
Lymphoepithelioma-like carcinoma of the lung: case in which the patient has been followed up for 7 years postoperatively. (16408473)
2005
28
Lymphoepithelioma-like carcinoma of urinary bladder: (LELCA). (16302478)
2005
29
Lymphoepithelioma-like carcinoma of the breast: report of a case mimicking lymphoma. (15494940)
2004
30
Clinical role of circulating Epstein-Barr virus DNA as a tumor marker in lymphoepithelioma-like carcinoma of the lung. (15251971)
2004
31
Intrahepatic cholangiocarcinoma with lymphoepithelioma-like carcinoma component. (15648792)
2004
32
Epstein-Barr virus-associated lymphoepithelioma-like carcinoma of the esophagus. (12733124)
2003
33
Eber- and LMP-1-expressing pulmonary lymphoepithelioma-like carcinoma in a Caucasian patient. (12827618)
2003
34
Unusual problems in breast cancer and a rare lung cancer case. Case 4. Primary lymphoepithelioma-like carcinoma of the lung. (12775751)
2003
35
Lymphoepithelioma-like carcinoma of the parotid gland in a patient with rheumatoid arthritis. (12508780)
2002
36
Lymphoepithelioma-like carcinoma of the cervix with prominent eosinophilic infiltrate: an HPV-18 associated case. (12047313)
2002
37
Circulating Epstein-Barr virus DNA in serum of patients with lymphoepithelioma-like carcinoma of the lung: a potential surrogate marker for monitoring disease. (11948104)
2002
38
Lymphoepithelioma-like carcinoma of the uterine cervix: a case report studied by in situ hybridization and polymerase chain reaction for Epstein-Barr virus. (10782160)
2000
39
Primary lymphoepithelioma-like carcinoma of the lung. (10704712)
2000
40
Lymphoepithelioma-like carcinoma of the renal pelvis. (10643022)
1999
41
Cytology of lymphoepithelioma-like carcinoma of the skin. (10450113)
1999
42
Neuroendocrine carcinoma of the skin with lymphoepithelioma-like features. (9790110)
1998
43
Expression of Epstein-Barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. (8600040)
1996
44
Lymphoepithelioma-like carcinoma of the rectum in a patient with ulcerative colitis. (8607522)
1996
45
Lymphoepithelioma-like carcinoma of the skin treated with Mohs micrographic surgery in combination with immune staining for cytokeratins. (7536761)
1995
46
Lymphoepithelioma-like carcinoma of the urinary bladder. (8172321)
1994
47
Lymphoepithelioma-like carcinoma of the skin: a light-microscopic and immunohistochemical study. (7699121)
1994
48
Detection of Epstein-Barr virus DNA in a Japanese case of lymphoepithelioma-like thymic carcinoma. (1313408)
1992
49
Lymphoepithelioma-like carcinoma of the lung. (1890841)
1991
50
Association of Epstein-Barr virus with undifferentiated gastric carcinomas with intense lymphoid infiltration. Lymphoepithelioma-like carcinoma. (1653517)
1991

Genetic Variations for Lymphoepithelioma-Like Carcinoma

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Expression for genes affiliated with Lymphoepithelioma-Like Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoepithelioma-Like Carcinoma

Search GEO for disease gene expression data for Lymphoepithelioma-Like Carcinoma.

Pathways for genes affiliated with Lymphoepithelioma-Like Carcinoma

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51QIAGEN, 59Tocris Bioscience, 29KEGG, 55SinoBiological, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1EGFR
210.1BCL2
3
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10.0TP53
4
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9.9TNFRSF8
59.8CDH1, EGFR
69.6TP53, BCL2
7
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9.6TP53, BCL2
89.4CGB, CDH1, TP53
9
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9.3PTPRC, BCL2, TP53
109.3TP53, EGFR, VIM
119.2EGFR, BCL2, TP53
12
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9.0BCL2, CDH1, MUC1, EGFR
139.0TP53, CDH1, MUC1, EGFR
148.9TP53, BCL2, EGFR, VIM
15
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8.9TP53, BCL2, CDH1, EGFR
16
Hide members
8.9TP53, BCL2, CDH1, EGFR
178.9EGFR, CDH1, BCL2, TP53
188.9EGFR, CDH1, BCL2, TP53
19
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8.5TNFRSF8, EGFR, CDH1, PTPRC, BCL2
20
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7.6VIM, TNFRSF8, EGFR, MUC1, CDH1, BCL2

Compounds for genes affiliated with Lymphoepithelioma-Like Carcinoma

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44Novoseek, 2BitterDB, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 121)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4ACPP
2aristolochic acid44 211.4VIM
3vincristine44 49 1112.4VIM
4glycogen44 2411.3PTPRC
5cycloheximide4410.3ALPP
6eosin4410.0VIM, S100B, MUC1
7s 100449.9MUC1, S100B, VIM
8sialic acid449.9PTPRC
9reticulin449.9VIM, S100B, MUC1
10adriamycin449.8BCL2, MUC1, VIM
11mucicarmine449.8MUC1, S100B, VIM
12tamoxifen44 49 28 1112.7EGFR, CDH1, ALPP
13temozolomide44 1110.5VIM, EGFR, TP53
14[alcl]449.5TNFRSF8, MUC1, PTPRC
15tartrate449.4ALPP, ACPP, VIM
16hydroxyapatite449.4VIM, S100B, CDH1, ALPP
17formaldehyde44 2410.4VIM, S100B, MUC1, CDH1, PTPRC
18suberoylanilide hydroxamic acid449.3TP53, BCL2, CDH1, EGFR
19vinblastine44 49 1111.3VIM, CDH1, BCL2, TP53
20creatinine449.3ALPP, ACPP, CDH1, CGB
21serine449.2S100B, CDH1, ACPP, ALPP
22taxane449.2TP53, BCL2, EGFR
23cytarabine44 49 1111.2VIM, MUC1, BCL2, TP53
24gemcitabine44 49 1111.2EGFR, MUC1, BCL2, TP53
25hematoxylin449.2VIM, S100B, CDH1, ACPP, PTPRC
26heparin44 28 11 2412.1PTPRC, CDH1, S100B, RPL22
27progestin449.0VIM, EGFR, MUC1, CDH1, ALPP
28dexamethasone44 49 28 1112.0S100B, CDH1, PTPRC, BCL2, ALPP
29paclitaxel44 49 1111.0S100B, EGFR, CDH1, BCL2, TP53
30thymidylate449.0VIM, EGFR, CDH1, BCL2, TP53
31agar449.0VIM, EGFR, MUC1, CDH1, ACPP
325fluorouracil448.9EGFR, MUC1, CDH1, BCL2, TP53
33n acetylcysteine448.9TP53, BCL2, PTPRC, CDH1, EGFR
34mg 13244 599.9TP53, BCL2, CDH1, EGFR
35b 723448.9VIM, S100B, MUC1, CDH1, PTPRC, ALPP
36etoposide44 49 59 1111.8VIM, S100B, CGB, CDH1, BCL2, TP53
37docetaxel44 49 59 1111.8EGFR, CDH1, BCL2, TP53
38doxorubicin44 49 1110.7VIM, EGFR, CDH1, BCL2, TP53
39genistein44 28 59 2 11 2413.6VIM, EGFR, CDH1, PTPRC, BCL2, ALPP
40lactate448.6VIM, S100B, CGB, CDH1, ACPP, ALPP
41retinoid448.5VIM, EGFR, CDH1, BCL2, ALPP, TP53
42cysteine448.5VIM, S100B, CGB, MUC1, CDH1, PTPRC
43sb 20358044 599.5VIM, EGFR, CDH1, BCL2, ALPP, TP53
44thymidine44 249.1S100B, TNFRSF8, MUC1, ACPP, ALPP, TP53
45retinoic acid44 248.9VIM, S100B, EGFR, MUC1, CDH1, BCL2
46cisplatin44 49 59 1110.7EGFR, CGB, MUC1, CDH1, ACPP, BCL2
47testosterone44 59 11 2410.7VIM, S100B, EGFR, CGB, MUC1, CDH1
48progesterone44 59 28 11 2411.4CGB, EGFR, S100B, VIM, MUC1, CDH1
49vegf447.1VIM, S100B, EGFR, CGB, MUC1, CDH1
50paraffin446.5TP53, VIM, S100B, TNFRSF8, EGFR, MUC1

GO Terms for genes affiliated with Lymphoepithelioma-Like Carcinoma

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16Gene Ontology
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Cellular components related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.5TP53, BCL2, CDH1, MUC1, EGFR, TNFRSF8

Biological processes related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1B cell lineage commitmentGO:0023269.7TP53, BCL2
2B cell proliferationGO:0421009.7PTPRC, BCL2
3digestive tract morphogenesisGO:0485469.7BCL2, EGFR
4regulation of mitochondrial membrane permeabilityGO:0469029.6BCL2, TP53
5DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.4TP53, MUC1
6cell-cell adhesionGO:0163379.4BCL2, CDH1, EGFR

Molecular functions related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein phosphatase 2A bindingGO:0517219.6TP53, BCL2
2identical protein bindingGO:0428027.8TP53, BCL2, ACPP, EGFR, S100B, VIM

Products for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Sources for Lymphoepithelioma-Like Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
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