MCID: LYM006
MIFTS: 56

Lymphoepithelioma-Like Carcinoma malady

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Summaries for Lymphoepithelioma-Like Carcinoma

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Wikipedia:65 Lymphoepithelioma-like carcinoma (LELC) is a medical term referring to a histological variant of... more...

MalaCards based summary: Lymphoepithelioma-Like Carcinoma, also known as nasopharyngeal type undifferentiated carcinoma, is related to histiocytosis and anaplastic large cell lymphoma. An important gene associated with Lymphoepithelioma-Like Carcinoma is CGB (chorionic gonadotropin, beta polypeptide), and among its related pathways are a6b1 and a6b4 Integrin signaling and E-cadherin signaling in keratinocytes. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and breast, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Disease Ontology:8 A carcinoma that is a malignant epithelial neoplasm densely infiltrated by lymphoid cells.

Aliases & Classifications for Lymphoepithelioma-Like Carcinoma

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Lymphoepithelioma-Like Carcinoma, Aliases & Descriptions:

Name: Lymphoepithelioma-Like Carcinoma 8 62
Nasopharyngeal Type Undifferentiated Carcinoma 8 62
 
Lymphoepithelial Carcinoma 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:5660
SNOMED-CT57 7300000
NCIt39 C4107

Related Diseases for Lymphoepithelioma-Like Carcinoma

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Diseases related to Lymphoepithelioma-Like Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis30.9ACPP, S100B
2anaplastic large cell lymphoma30.6TNFRSF8, PTPRC, MUC1
3adenosquamous carcinoma30.5EGFR, MUC1
4gastrointestinal stromal tumor30.5S100B, VIM
5cholangiocarcinoma30.2TP53, MUC1, ALPP, CDH1, CGB
6lung cancer30.0TP53, EGFR, CGB
7colorectal cancer29.4TP53, MUC1, ALPP, CDH1, EGFR, CGB
8adenocarcinoma29.4CGB, EGFR, CDH1, ACPP, MUC1, VIM
9breast cancer29.0TNFRSF8, TP53, MUC1, ACPP, ALPP, CDH1
10giant cell tumor10.6ACPP
11hidradenoma10.6MUC1
12papilloma10.6
13superior vena cava syndrome10.6CGB
14gemistocytic astrocytoma10.5S100B
15eccrine porocarcinoma10.5MUC1
16cystadenocarcinoma10.5MUC1
17rosai-dorfman disease10.5S100B
18adenomatoid tumor10.5VIM
19paraganglioma10.5VIM
20sinonasal undifferentiated carcinoma10.5
21infiltrating bladder lymphoepithelioma-like carcinoma10.5
22lymphoepithelioma-like thymic carcinoma10.5
23cervical lymphoepithelioma-like carcinoma10.5
24nasopharyngitis10.5
25thyroiditis10.5
26syringoma10.4MUC1, S100B
27fibrous meningioma10.4S100B, MUC1
28choroid plexus papilloma10.4MUC1, S100B
29anaplastic ependymoma10.4MUC1, S100B
30ulcerative colitis10.4
31basal cell carcinoma10.4
32colitis10.4
33thymoma10.4
34germinoma10.4CGB, ALPP
35hemangioblastoma10.4MUC1, S100B
36giant cell glioblastoma10.3EGFR
37thymus cancer10.3MUC1, ALPP
38clear cell ependymoma10.3MUC1, VIM
39mesenchymal chondrosarcoma10.3VIM, MUC1
40phyllode tumor10.3VIM, ACPP
41malignant fibroxanthoma10.3TP53, ACPP
4221-hydroxylase deficiency10.3ACPP, ALPP
43spindle cell carcinoma10.3VIM, MUC1
44epithelioid sarcoma10.3MUC1, VIM
45gestational trophoblastic neoplasm10.3ALPP, CGB
46secretory meningioma10.3VIM, MUC1
47myoepithelioma10.3VIM, S100B
48granular cell tumor10.3VIM, S100B
49fibrous histiocytoma10.3VIM, S100B
50angiomyolipoma10.3PTPRC, VIM

Graphical network of the top 20 diseases related to Lymphoepithelioma-Like Carcinoma:



Diseases related to lymphoepithelioma-like carcinoma

Symptoms for Lymphoepithelioma-Like Carcinoma

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Drugs & Therapeutics for Lymphoepithelioma-Like Carcinoma

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Drug clinical trials:

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Genetic Tests for Lymphoepithelioma-Like Carcinoma

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Anatomical Context for Lymphoepithelioma-Like Carcinoma

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MalaCards organs/tissues related to Lymphoepithelioma-Like Carcinoma:

32
Lung, Skin, Breast, Cervix, Salivary gland, Colon, Thyroid, Ovary, Trachea, Lymph node, Thymus, Kidney, Prostate, Testes, Tonsil, T cells, B cells

Animal Models for Lymphoepithelioma-Like Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Lymphoepithelioma-Like Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6PTPRC, TP53, MUC1, CDH1, EGFR
2MP:00030128.5PTPRC, TP53, MUC1, CDH1, EGFR
3MP:00053818.5PTPRC, TP53, MUC1, CDH1, EGFR
4MP:00107718.4TP53, MUC1, ACPP, S100B, CDH1, EGFR
5MP:00053847.8EGFR, CDH1, RPL22, VIM, TP53, PTPRC
6MP:00053807.6TP53, VIM, ALPP, CDH1, EGFR
7MP:00053977.6TNFRSF8, PTPRC, TP53, VIM, RPL22, EGFR
8MP:00053877.4TNFRSF8, PTPRC, TP53, VIM, RPL22, CDH1
9MP:00053787.1PTPRC, TP53, VIM, RPL22, ALPP, CDH1
10MP:00028736.9EGFR, PTPRC, TP53, MUC1, RPL22, ALPP

Publications for Lymphoepithelioma-Like Carcinoma

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Articles related to Lymphoepithelioma-Like Carcinoma:

(show top 50)    (show all 239)
idTitleAuthorsYear
1
Lymphoepithelioma-like Carcinoma of the Endometrium: Immunophenotypic Characterization of a Rare Tumor With Microsatellite Instability Testing. (24300538)
2014
2
Lymphoepithelioma-like carcinoma of the breast: Cytological, histological, and immunohistochemical characteristics. (24610805)
2014
3
Lymphoepithelioma-like carcinoma of the urinary bladder: a case report and review of the literature. (25367311)
2014
4
Lymphoepithelioma-like carcinoma of the colon. (23626513)
2013
5
Intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation; comparison with thymic lymphoepithelioma-like carcinoma and a possibility of development from a multipotential stem cell. (23176314)
2013
6
Lymphoepithelioma-like carcinoma of the breast: cytological and histological features and review of the literature. (22236751)
2012
7
Lymphoepithelioma-like carcinoma of the colon. (22295155)
2012
8
Lymphoepithelioma-like carcinoma in a patient with mycosis fungoides. (22527441)
2012
9
Lymphoepithelioma-like carcinoma of the skin treated with wide local excision and chemoradiation therapy: a case report and review of the literature. (23133769)
2012
10
Primary pulmonary lymphoepithelioma-like carcinoma: fifty-two patients with long-term follow-up. (22359203)
2012
11
Lymphoepithelioma-like carcinoma of the ovary. (20444729)
2011
12
Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature. (20952226)
2011
13
Cutaneous lymphoepithelioma-like carcinoma: report of three cases. (22295745)
2011
14
Primary lymphoepithelioma-like carcinoma of the ureter. (20471568)
2010
15
Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma. (21080882)
2010
16
Cytology of lymphoepithelioma-like carcinoma of the urinary bladder. (19456843)
2009
17
Lymphoepithelioma-like carcinoma of the uterine cervix. (19238413)
2009
18
Pleomorphic lymphoepithelioma-like carcinoma of the urinary bladder. (19079656)
2009
19
Capecitabine as salvage treatment for lymphoepithelioma-like carcinoma of lung. (19704339)
2009
20
Lymphoepithelioma-like carcinoma of the prostate. (19269013)
2009
21
Lymphoepithelioma-like carcinoma of the skin mimicking a basal cell carcinoma. (19106051)
2009
22
Thymic lymphoepithelioma-like carcinoma mimicking primary tumor of the lung. (19618760)
2009
23
Lymphoepithelioma-like carcinoma of the urinary bladder in a cow associated with bovine papillomavirus type-2. (18675990)
2008
24
Lymphoepithelioma-like carcinoma arising in the scar from a previously excised basal cell carcinoma. (18201243)
2008
25
Lymphoepithelioma-like carcinoma of the ovary: a case report and review of the literature. (17979492)
2007
26
Lymphoepithelioma-like carcinoma of the renal pelvis. (18036048)
2007
27
Primary lymphoepithelioma-like carcinoma of minor salivary gland: a case report with immunohistochemical and in situ hybridization studies. (16240326)
2006
28
Lymphoepithelioma-like carcinoma of the breast mimicking nodular sclerosing Hodgkin's lymphoma. (16174158)
2005
29
Lymphoepithelioma-like carcinoma of the breast: report of a case mimicking lymphoma. (15494940)
2004
30
Clinical role of circulating Epstein-Barr virus DNA as a tumor marker in lymphoepithelioma-like carcinoma of the lung. (15251971)
2004
31
Simultaneous EBV-positive lymphoepithelioma-like carcinoma and EBV-negative intestinal-type adenocarcinoma in a patient with Helicobacter pylori-associated chronic gastritis. (14983938)
2004
32
Computed tomography characteristics of advanced primary pulmonary lymphoepithelioma-like carcinoma. (12594554)
2003
33
Lymphoepithelioma-like carcinoma of the uterine cervix. (12456211)
2002
34
Lymphoepithelioma-like carcinoma of the breast. (12193205)
2002
35
Lymphoepithelioma-like carcinoma of the urinary bladder: a clinicopathologic study of 13 cases. (11469686)
2001
36
Ectopic production and localization of beta-human chorionic gonadotropin in lymphoepithelioma-like carcinoma of the cervix: a case report. (10782417)
2000
37
Lymphoepithelioma-like carcinoma of the uterine cervix: a case report studied by in situ hybridization and polymerase chain reaction for Epstein-Barr virus. (10782160)
2000
38
Case report: A case of lymphoepithelioma-like carcinoma of the oesophagus and review of the literature. (10385061)
1999
39
Case report of lymphoepithelioma-like carcinoma of the lung--lymphoid population consisting of cytotoxic T cells in resting state. (10605698)
1999
40
Lymphoepithelioma-like carcinoma of the colon: report of a case with histologic, immunohistochemical, and molecular studies for Epstein-Barr virus. (9678381)
1998
41
Expression of Epstein-Barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. (8600040)
1996
42
Lymphoepithelioma-like carcinoma of the lung. Two cases diagnosed in Caucasian patients. (7778219)
1995
43
Epstein-Barr virus is detected in undifferentiated nasopharyngeal carcinoma but not in lymphoepithelioma-like carcinoma of the urinary bladder. (7590694)
1995
44
Lymphoepithelioma-like carcinoma of the lung. (8822122)
1995
45
Fine-needle aspiration cytologic diagnosis of lymphoepithelioma-like carcinoma of the lung. Report of two cases with immunohistochemical study. (7817941)
1995
46
Lymphoepithelioma-like carcinoma of the urinary bladder. (8172321)
1994
47
Lymphoepithelioma-like carcinoma of the skin: a light-microscopic and immunohistochemical study. (7699121)
1994
48
Lymphoepithelioma-like carcinoma of the lung. (2546459)
1989
49
Lymphoepithelioma-like carcinoma of the skin. (3237711)
1988
50
Epstein-Barr virus related lymphoepithelioma-like carcinoma of lung. (2826922)
1987

Variations for Lymphoepithelioma-Like Carcinoma

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Expression for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Expression patterns in normal tissues for genes affiliated with Lymphoepithelioma-Like Carcinoma

Search GEO for disease gene expression data for Lymphoepithelioma-Like Carcinoma.

Pathways for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Pathways related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6EGFR, CDH1
29.6CDH1, EGFR
39.6EGFR, CDH1
49.5CDH1, TP53
59.5EGFR, TP53
6
Show member pathways
Development ERBB family signaling60
Development GDNF family signaling60
9.3EGFR, CDH1, MUC1
79.3TP53, CDH1, CGB
89.2TP53, VIM, CDH1
99.1EGFR, VIM, TP53
109.1EGFR, CDH1, TP53
11
Show member pathways
Signal transduction PTEN pathway60
9.1TP53, CDH1, EGFR
12
Show member pathways
Signaling Pathways in Glioblastoma37
9.1EGFR, CDH1, TP53
139.1TP53, CDH1, EGFR
148.8EGFR, CDH1, MUC1, TP53
15
Show member pathways
8.8TNFRSF8, PTPRC, CDH1, EGFR
16
Show member pathways
7.9TNFRSF8, TP53, VIM, MUC1, CDH1, EGFR

Compounds for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Compounds related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 117)
idCompoundScoreTop Affiliating Genes
1eosin449.9VIM, S100B, MUC1
2s 100449.8MUC1, S100B, VIM
3reticulin449.8VIM, MUC1, S100B
4mucicarmine449.8S100B, MUC1, VIM
5[alcl]449.6TNFRSF8, PTPRC, MUC1
6aristolochic acid44 210.5TP53, VIM, CDH1
7tartrate449.4ACPP, VIM, ALPP
8sialic acid449.4PTPRC, S100B, MUC1, CDH1
9temozolomide44 1110.3VIM, EGFR, TP53
10dihydrotestosterone44 28 24 1112.3MUC1, CDH1, ACPP, VIM
11hyaluronic acid44 2410.2MUC1, CDH1, PTPRC, VIM
12crcs449.2TP53, CDH1, MUC1
13adriamycin449.2TP53, VIM, CDH1, MUC1
14formaldehyde44 2410.1PTPRC, S100B, MUC1, CDH1, VIM
15agar449.0MUC1, EGFR, CDH1, ACPP, VIM
16glycogen44 2410.0CDH1, S100B, MUC1, VIM, PTPRC
17thymidylate449.0VIM, TP53, EGFR, CDH1
18etoposide44 50 61 1111.9CGB, TP53, CDH1, S100B, VIM
19acth448.9ACPP, PTPRC, MUC1, S100B
20hydroxyapatite448.9VIM, ALPP, CDH1, S100B
21hematoxylin448.9ACPP, MUC1, PTPRC, S100B, VIM, CDH1
22cyclic amp44 249.8VIM, CGB, S100B, MUC1, CDH1
23paclitaxel44 50 1110.7S100B, VIM, TP53, EGFR, CDH1
24folate448.7VIM, CDH1, MUC1, ALPP
25dmso448.6MUC1, ALPP, PTPRC, VIM
26progestin448.5CDH1, ALPP, EGFR, MUC1, VIM
27butyrate448.4TP53, ALPP, VIM, MUC1, CDH1
28lactate448.4CGB, CDH1, VIM, ACPP, ALPP, S100B
29genistein44 28 61 2 24 1113.4CDH1, PTPRC, EGFR, VIM, ALPP
30b 723448.4S100B, CDH1, ALPP, VIM, MUC1, PTPRC
31aspartate448.3ALPP, S100B, CDH1, VIM, ACPP
32retinoid448.3CDH1, ALPP, VIM, TP53, EGFR
33sb 20358044 619.3TP53, EGFR, CDH1, ALPP, VIM
34alanine448.3VIM, ACPP, ALPP, S100B, CDH1, CGB
35dexamethasone44 50 28 1111.2PTPRC, VIM, MUC1, ALPP, CDH1, S100B
36creatinine448.1ALPP, S100B, CDH1, ACPP, CGB, VIM
37thymidine44 249.1ALPP, S100B, MUC1, TP53, TNFRSF8, ACPP
38cysteine448.0S100B, CGB, CDH1, VIM, MUC1, ALPP
39arginine448.0VIM, ACPP, ALPP, S100B, CDH1, TP53
40tamoxifen44 50 28 1111.0EGFR, TP53, VIM, ALPP, CDH1, MUC1
41heparin44 28 24 1111.0CDH1, VIM, PTPRC, RPL22, ALPP, S100B
42tyrosine447.9EGFR, S100B, CDH1, MUC1, TNFRSF8, PTPRC
43cisplatin44 50 61 1110.8MUC1, ACPP, CDH1, EGFR, CGB, ALPP
44retinoic acid44 248.6MUC1, ALPP, TP53, VIM, EGFR, S100B
45progesterone44 28 61 24 1111.6MUC1, VIM, ACPP, S100B, EGFR, CGB
46testosterone44 61 24 1110.3VIM, ACPP, CDH1, MUC1, CGB, PTPRC
47vegf447.1TP53, EGFR, CGB, ALPP, ACPP, S100B
48estrogen446.8CDH1, ALPP, S100B, ACPP, PTPRC, VIM
49paraffin446.6MUC1, VIM, TNFRSF8, PTPRC, EGFR, CDH1
50serine446.6ACPP, CDH1, S100B, ALPP, MUC1, VIM

GO Terms for genes affiliated with Lymphoepithelioma-Like Carcinoma

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Cellular components related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.4MUC1, ALPP, CDH1, EGFR
2extracellular vesicular exosomeGO:0700628.1RPL22, ACPP, MUC1, VIM, PTPRC, TNFRSF8
3plasma membraneGO:0058867.3PTPRC, VIM, ACPP, ALPP, CDH1, EGFR
4cytoplasmGO:0057376.6TNFRSF8, TP53, VIM, MUC1, RPL22, S100B

Biological processes related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069789.7MUC1, TP53
2learning or memoryGO:0076119.4EGFR, S100B
3dephosphorylationGO:0163119.1ALPP, ACPP, PTPRC
4positive regulation of apoptotic processGO:0430659.1S100B, TP53, TNFRSF8
5apoptotic processGO:0069158.8TP53, VIM, CDH1, CGB

Molecular functions related to Lymphoepithelioma-Like Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.1EGFR, CDH1, VIM
2protein phosphatase bindingGO:0199038.8TP53, CDH1, EGFR
3identical protein bindingGO:0428028.5EGFR, S100B, ACPP, VIM, TP53
4protein bindingGO:0055157.5EGFR, CDH1, S100B, ACPP, MUC1, VIM

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