MCID: LYM067
MIFTS: 43

Lymphoid Leukemia

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Lymphoid Leukemia

MalaCards integrated aliases for Lymphoid Leukemia:

Name: Lymphoid Leukemia 37 28 69

Classifications:



Summaries for Lymphoid Leukemia

MalaCards based summary : Lymphoid Leukemia is related to leukemia, chronic lymphocytic and lymphoblastic leukemia. An important gene associated with Lymphoid Leukemia is KMT2A (Lysine Methyltransferase 2A), and among its related pathways/superpathways are NF-kappaB Signaling and Transcriptional misregulation in cancer. The drugs Dasatinib and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are growth/size/body region and hematopoietic system

Related Diseases for Lymphoid Leukemia

Diseases related to Lymphoid Leukemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 leukemia, chronic lymphocytic 30.7 BCR CD5 ZAP70
2 lymphoblastic leukemia 30.7 BCR ETV6 RUNX1
3 leukemia 29.4 BCR ETV6 KMT2A RUNX1 RUNX1T1
4 myelodysplastic syndrome 29.3 ETV6 KMT2A RUNX1
5 acute leukemia 29.2 ETV6 KMT2A RUNX1
6 leukemia, chronic myeloid 28.9 BCR ETV6 RUNX1
7 myeloid leukemia 28.8 BCR ETV6 RUNX1 RUNX1T1
8 leukemia, acute myeloid 27.2 BCR CD5 ETV6 KMT2A RUNX1 RUNX1T1
9 adult acute lymphocytic leukemia 11.0
10 ring chromosome 21 10.4 ETV6 KMT2A
11 intravascular large b-cell lymphoma 10.2 CD5 KMT2A
12 chromosomal triplication 10.2 KMT2A ZAP70
13 platelet disorder, familial, with associated myeloid malignancy 10.1 ETV6 RUNX1
14 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.1 RUNX1 RUNX1T1
15 b cell prolymphocytic leukemia 10.0 CD5 ZAP70
16 cll/sll 10.0 CD5 ZAP70
17 cd45 deficiency 10.0 CD5 ZAP70
18 chronic myelomonocytic leukemia 10.0 ETV6 RUNX1
19 lymphoma 9.9
20 multiple cranial nerve palsy 9.9 RUNX1 RUNX1T1
21 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.9 ETV6 KMT2A RUNX1
22 childhood leukemia 9.9 ETV6 KMT2A RUNX1
23 prolymphocytic leukemia 9.9 CD5 ZAP70
24 lymphoblastic lymphoma 9.9 CD5 KMT2A
25 acute lymphoblastic leukemia, childhood 9.9 ETV6 RUNX1
26 cryoglobulinemia, familial mixed 9.8 BCR CD5
27 richter's syndrome 9.8 BCR CD5
28 hairy cell leukemia 9.7
29 lymphosarcoma 9.7
30 precursor t-cell acute lymphoblastic leukemia 9.7 BCR ETV6 KMT2A
31 8p11 myeloproliferative syndrome 9.7 BCR RUNX1
32 blood group, i system 9.6
33 porphyria cutanea tarda 9.6
34 retinoblastoma 9.6
35 myelofibrosis 9.6
36 myeloma, multiple 9.6
37 arthritis 9.6
38 hematopoietic stem cell transplantation 9.6
39 peripheral t-cell lymphoma 9.6
40 renal tubular acidosis 9.6
41 mucositis 9.6
42 pulmonary alveolar proteinosis 9.6
43 bronchopneumonia 9.6
44 porphyria 9.6
45 panniculitis 9.6
46 histoplasmosis 9.6
47 papillary carcinoma 9.6
48 endophthalmitis 9.6
49 t-cell leukemia 9.6
50 thyroiditis 9.6

Comorbidity relations with Lymphoid Leukemia via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Leukemia, Chronic Lymphocytic

Graphical network of the top 20 diseases related to Lymphoid Leukemia:



Diseases related to Lymphoid Leukemia

Symptoms & Phenotypes for Lymphoid Leukemia

MGI Mouse Phenotypes related to Lymphoid Leukemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.87 BCR ETV6 KMT2A NCKIPSD RUNX1 RUNX1T1
2 hematopoietic system MP:0005397 9.73 BCR CD5 ETV6 KMT2A RUNX1 ZAP70
3 integument MP:0010771 9.63 CD5 ETV6 KMT2A RUNX1 RUNX1T1 ZAP70
4 no phenotypic analysis MP:0003012 9.35 ETV6 KMT2A NCKIPSD RUNX1 CD5
5 normal MP:0002873 9.23 BCR CD5 ETV6 KMT2A RUNX1 RUNX1T1

Drugs & Therapeutics for Lymphoid Leukemia

Drugs for Lymphoid Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 689)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dasatinib Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 302962-49-8 3062316
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 50-02-2 5743
3
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 53-03-2 5865
5
Asparaginase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 9015-68-3
6
Cytarabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 147-94-4 6253
7
Daunorubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 20830-81-3 30323
8
Idarubicin Approved Phase 4,Phase 3,Phase 2,Phase 1 58957-92-9 42890
9
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2068-78-2, 57-22-7 5978
10
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
11
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 23214-92-8 31703
12
Pegaspargase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 130167-69-0
13
Lenograstim Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 135968-09-1
14
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
15
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
16
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 174722-31-7 10201696
17
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
18
Pentostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53910-25-1 439693 40926
19
Cladribine Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 4291-63-8 20279
20
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 33419-42-0 36462
21
Fludarabine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 21679-14-1, 75607-67-9 30751
22
Teniposide Approved Phase 4,Phase 3,Phase 2 29767-20-2 34698
23
Thioguanine Approved Phase 4,Phase 3,Phase 2,Phase 1 154-42-7 2723601
24
Vindesine Approved, Investigational Phase 4,Phase 3,Phase 2 53643-48-4, 59917-39-4 40839
25
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 3778-73-2 3690
26
Chlorambucil Approved Phase 4,Phase 3,Phase 2,Phase 1 305-03-3 2708
27
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 657311 5754
28
Mitoxantrone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 65271-80-9 4212
29
Vidarabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 24356-66-9 21704 32326
30 Thiotepa Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 52-24-4 5453
31
Busulfan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 55-98-1 2478
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
33
Valganciclovir Approved, Investigational Phase 4,Phase 2 175865-60-8 64147
34
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
35
Methylphenidate Approved, Investigational Phase 4 20748-11-2, 113-45-1 4158
36
Oprelvekin Approved, Investigational Phase 4 145941-26-0
37
Menthol Approved Phase 4 2216-51-5 16666
38
Micafungin Approved, Investigational Phase 4,Phase 2 235114-32-6 477468 3081921
39
Posaconazole Approved, Investigational, Vet_approved Phase 4 171228-49-2 147912
40
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2 1397-89-3 5280965 14956
41
Nicotine Approved Phase 4 54-11-5 89594 942
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
43
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 143 6006
44
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3,Early Phase 1 67-97-0 10883523 5280795 6221
45
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 1406-16-2
46
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 50-14-6 5280793
47
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 31703
48
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2,Phase 1 107-92-6 264
49
Treosulfan Investigational Phase 4,Phase 3,Phase 2,Phase 1 299-75-2 9296
50 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 2670)

# Name Status NCT ID Phase Drugs
1 Low-dose Chemotherapy Combine With Tyrosine Kinase Inhibitor to Treat ph+ Acute Lymphoblastic Leukemia Patients Unknown status NCT02690922 Phase 4 Dasatinib;prednisone;dexamethasone;methotrexate
2 Treatment Protocol of Children With Philadelphia Chromosome Negative High Risk Acute Lymphoblastic Leukemia Unknown status NCT01990807 Phase 4 Idarubicin(IDA)
3 Medical Research Council (MRC) Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003 Unknown status NCT00222612 Phase 4 Standard childhood UK ALL protocol;Intensified treatment including Capizzi maintenance
4 German Multicenter Trial for Treatment of Elderly Patients With Newly Diagnosed Acute Lymphoblastic Leukemia Unknown status NCT00198978 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Cytarabine;Idarubicin;Granulocyte-Colony-Stimulating Factor;Mercaptopurine;Methotrexate;Rituximab;HDARAC;Vincristine;Depocyte;Asparaginase
5 Efficacy and Safety of Nipent, Cytoxan and Rituxan in the Treatment of Chronic Lymphocytic Leukemia. Unknown status NCT00131313 Phase 4 Nipent, Cytoxan, Rituxan
6 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003) Unknown status NCT00198991 Phase 4 Cyclophosphamide;Dexamethasone;Vincristine;daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Prednisolone;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Cladribine
7 Poly(Ethylene Glycol)(PEG)-Asparaginase During Two Treatment Courses Unknown status NCT00192673 Phase 4 PEG-asparaginase
8 HD-Idarubicin/Etoposide Intensified Conditioning Regimen Allo-HSCT for Adult ALL Unknown status NCT01873807 Phase 4 IDA;CTX;VP-16
9 Intensification Therapy of Mature B-ALL, Burkitt and Burkitt Like and Other High Grade Non-Hodgkin's Lymphoma in Adults Unknown status NCT00797810 Phase 4 Rituximab
10 ATG Could Improve the Outcome Of Hematopoietic Stem Cell Transplant in Patients With Highly Aggressive T Cell Tumors Unknown status NCT02290132 Phase 4 Rabbit Anti-human Thymocyte Globulin (ATG)
11 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
12 Pulses of Vincristine and Dexamethasone in BFM Protocols for Children With Acute Lymphoblastic Leukemia Completed NCT00411541 Phase 4 vincristine;dexamethasone
13 Observational Study in Participants With Chronic Lymphocytic Leukemia (CLL), Multiple Myeloma (MM) and Non-Hodgkin's Lymphoma (NHL) in Latin America Completed NCT02559583 Phase 4
14 A Study of MabThera Added to Bendamustine or Chlorambucil in Patients With Chronic Lymphocytic Leukemia (MaBLe) Completed NCT01056510 Phase 4 bendamustine;chlorambucil;rituximab [MabThera/Rituxan]
15 Rituximab Plus Chemotherapy for CD20+ Adult Acute Lymphoblastic Leukemia Completed NCT01358253 Phase 4 Cyclophosphamide;Doxorubicin;Vincristine;Dexamethasone;Cytarabine;Methotrexate;Rituximab;6-Mercaptopurine;Prednisone;L-asparaginase
16 LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia Completed NCT00526409 Phase 4 Prednisolone;Daunorubicin;Vincristine;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside
17 PETHEMA LAL-RI/96: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Completed NCT00494897 Phase 4 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin;Mercaptopurine;Prednisone;Vincristine;Methotrexate
18 LAL-Ph-2000: Treatment of Acute Lymphoblastic Leukemia Chromosome Philadelphia Positive Completed NCT00526305 Phase 4 Vincristine;Daunorubicin;Prednisone;L-Asparaginase;Mitoxantrone;Cytosine Arabinoside;Hydrocortisone;Mercaptopurine;Cyclophosphamide;Dexamethasone
19 Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia Completed NCT00199095 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone;Idarubicin;Ifosfamide;Methotrexate;Mercaptopurine;VM26;Vincristine
20 Antiviral Treatment of Chronic Lymphocytic Leukemia Completed NCT01255644 Phase 4 Valganciclovir
21 A Study of Rituximab in Combination With Fludarabine and Cyclophosphamide in Participants With Chronic Lymphocytic Leukemia and Favorable Somatic Status Completed NCT01271010 Phase 4 Cyclophosphamide;Fludarabine;Rituximab
22 A Study to Compare Mabthera (Rituximab), Fludarabine and Cyclophosphamide to Mabthera and Chlorambucil in Patients With Chronic Lymphocytic Leukemia and Unfavourable Somatic Status Completed NCT01283386 Phase 4 chlorambucil;cyclophosphamide;fludarabine;rituximab [MabThera]
23 ALL-REZ BFM 2002: Multi-Center Study for Children With Relapsed Acute Lymphoblastic Leukemia Completed NCT00114348 Phase 4
24 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93) Completed NCT00199069 Phase 4 Asparaginase;Vincristine;Daunorubicin, Adriamycin;Cyclophosphamide;Ifosfamide;Cytarabine;Mitoxantrone;Methotrexate;6-Mercaptopurine;6-Thioguanine;VM26;Dexamethasone / Prednisolone
25 German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99) Completed NCT00199056 Phase 4 Dexamethasone / Prednisolone;Cyclophosphamide;Methotrexate;Vincristine / Vindesine;Daunorubicin;Asparaginase;G-CSF;Cytarabine;6-Mercaptopurine;VP16;Adriamycin;Thioguanine;VM26;Idarubicin;Fludarabine;Ifosfamide
26 Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab Completed NCT00199004 Phase 4 Cyclophosphamide;Dexamethasone / Prednisolone;Vincristine;Daunorubicin;Asparaginase;Methotrexate;Cytarabine;Mercaptopurine;G-CSF;Vindesine;VP16;Adriamycin;Thioguanine;VM26;Rituximab
27 A Study to Confirm the Efficacy and Safety of Fludarabine Phosphate Administered in Untreated Chronic Lymphocytic Leukemia Patients With Anemia and/or Thrombocytopenia Completed NCT00220311 Phase 4 Fludarabine Phosphate (Fludara)
28 Learning Impairments Among Survivors of Childhood Cancer Completed NCT00576472 Phase 4 Methylphenidate
29 Efficacy and Safety of Ofatumumab Retreatment and Maintenance Treatment in Patients With B-cell Chronic Lymphocytic Leukemia (CLL) Completed NCT00802737 Phase 4 Ofatumumab
30 LAL-BR/2001: Study Treatment to Low Risk ALL Completed NCT00526175 Phase 4 Prednisone;Vincristine;Daunorubicin;L-Asparaginase;Cyclophosphamide;Methotrexate;Cytosine Arabinoside;Mercaptopurine;VP-16
31 The Study on the Pharmacokinetics of PEG-rhG-CSF in Children and Adolescents Completed NCT02953730 Phase 4 PEG-rhG-CSF
32 Effect of rhIL-11 in Patients With Thrombocytopenia for Childhood ALL Completed NCT02314273 Phase 4 rhIL-11
33 The Duration of Humoral Immunity and the Memory Cell Function After Vaccination With 7-valent Pneumococcal Conjugate Vaccine in CLL Completed NCT00919321 Phase 4
34 Effect of Epoetin Alfa on Hemoglobin, Symptom Distress, and Quality of Life in Patients Receiving Chemotherapy Completed NCT00524407 Phase 4 Epoetin alfa
35 Trial for the Treatment of Newly Diagnosed Mature B-Cell Acute Lymphoblastic Leukemia (B-ALL), Burkitt's Non-Hodgkin's Lymphoma (NHL) and Other High-grade Lymphoma in Adults Completed NCT00199082 Phase 4 Adriamycin;Cyclophosphamide;Cytarabine;Dexamethasone/Prednisolone;VP16;Ifosfamide;Methotrexate;G-CSF;Rituximab;Vincristine/Vindesine
36 German Multicenter Trial for the Treatment of Newly Diagnosed T-lymphoblastic Lymphoma in Adults Completed NCT00199017 Phase 4 Dexamethasone/Prednisolone;Cyclophosphamide;Vincristine;Daunorubicin;Asparaginase;G-CSF;Mercaptopurine;Cytarabine;Methotrexate;VP16;Vindesine;Adriamycin;Thioguanine;HDARAC;Cladribine
37 Bone Marrow Transplantation in Treating Patients With Hematologic Cancer Completed NCT00003398 Phase 4 cyclophosphamide;thiotepa
38 Identification of New Immune Factors Specific of Relapse in Childhood B Lineage Acute Lymphoblastic Leukemia Recruiting NCT02618109 Phase 4
39 Protocol For the Treatment Acute Lymphoblastic Leukemia With Ph 'Negative in Elderly Patients (> 55 Years) Recruiting NCT01366898 Phase 4 Dexamethasona, Idarubicine, ARA-C, Methotrexate
40 The GD-2008 ALL Protocol for Childhood Acute Lymphoblastic Leukemia Recruiting NCT00846703 Phase 4 6-mercaptopurine, Methotrexate;6-mercaptopurine, Methotrexate, Vincristine, Dexamethasone
41 Malaysia-Singapore Acute Lymphoblastic Leukemia 2010 Study Recruiting NCT02894645 Phase 4 Prednisolone;Dexamethasone;L-Asparaginase;Vincristine;Methotrexate;Daunorubicin;Doxorubicin;Cyclophosphamide;Cytarabine;6-Mercaptopurine;Thioguanine;Fludarabine;Imatinib
42 Chemotherapy and Imatinib in Young Adults With Acute Lymphoblastic Leukemia Ph (BCR-ABL) POSITIVE Recruiting NCT01491763 Phase 4 Imatinib
43 Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid Recruiting NCT01906671 Phase 4 Xaluprine;Puri-Nethol
44 PETHEMA LAL-07FRAIL: All Treatment In Fragile Patients Ph' Negative Over 55 Years Recruiting NCT01358201 Phase 4 vINCRISTINE;Dexamethasone;Methotrexate;Cytosine arabinoside
45 Vaccinating Children After Chemotherapy Recruiting NCT02447718 Phase 4
46 ALL SCTped FORUM - Pharmacogenomic Study (add-on Study) Recruiting NCT02670564 Phase 4
47 Pethema LAL-RI/2008: Treatment for Patients With Standard Risk Acute Lymphoblastic Leukemia Recruiting NCT02036489 Phase 4 Vincristine;Daunorubicin;Prednisone;L-asparaginase;Ciclophosphamide;Metotrexate;ARA-C;Hidrocortisone;Mercaptopurine;VP-16;Dexametasone
48 Low Grade Lymphoma Recruiting NCT01698866 Phase 4
49 ATG Based Conditioning Regimen in HLA Related HSCT for Aggressive T-cell Tumors Recruiting NCT02938741 Phase 4 Anti-human Thymoglobulin;Placebo
50 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate

Search NIH Clinical Center for Lymphoid Leukemia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoid Leukemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Lymphoid Leukemia:
StemEx
Embryonic/Adult Cultured Cells Related to Lymphoid Leukemia:
Umbilical cord blood stem/progenitor cells (Stemex) PMIDs: 18209724

Genetic Tests for Lymphoid Leukemia

Genetic tests related to Lymphoid Leukemia:

# Genetic test Affiliating Genes
1 Lymphoid Leukemia 28

Anatomical Context for Lymphoid Leukemia

MalaCards organs/tissues related to Lymphoid Leukemia:

38
B Cells, T Cells, Bone, Bone Marrow, Myeloid, Kidney, Nk Cells

Publications for Lymphoid Leukemia

Articles related to Lymphoid Leukemia:

(show top 50) (show all 126)
# Title Authors Year
1
Proteomic Profile of Lymphoid Leukemia. ( 29394974 )
2018
2
DNA damage response in patients with pediatric Acute Lymphoid Leukemia during induction therapy. ( 28109975 )
2017
3
Peripheral T-Cell Lymphoma in Mediastinum Lymph Nodes and Lung Associated to Histoplasmosis in a Patient with Chronic Lymphoid Leukemia/Small Lymphocytic Lymphoma. ( 28698787 )
2017
4
Incidence of Myelofibrosis in Chronic Myeloid Leukemia, Multiple Myeloma, and Chronic Lymphoid Leukemia during Various Phases of Diseases. ( 28239786 )
2017
5
Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia. ( 28171800 )
2017
6
Inverse Correlation of Lymphoid Leukemia Incidence and Anemia Prevalence among Preschool Children. ( 28464174 )
2017
7
Time and spatial trends in lymphoid leukemia and lymphoma incidence and survival among children and adolescents in Manitoba, Canada: 1984-2013. ( 28430788 )
2017
8
Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells. ( 28744653 )
2017
9
KML001 and doxercalciferol induce synergistic antileukemic effect in acute lymphoid leukemia cells. ( 28586017 )
2017
10
Extramedullary Relapse of Acute Myeloid and Lymphoid Leukemia in Children: A Retrospective Analysis. ( 27617062 )
2016
11
Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states. ( 27913602 )
2016
12
Advanced chronic lymphoid leukemia with severe bronchopneumonia: an Autopsy Case Report. ( 27284536 )
2016
13
Specific Antileukemic Activity of PD0332991, a CDK4/6 Inhibitor, against Philadelphia Chromosome-Positive Lymphoid Leukemia. ( 26637365 )
2016
14
Type distribution of lymphoid leukemia from Cancer Incidence in Five Continents Vol. X. ( 26941374 )
2016
15
Non-biased and complete case registration of lymphoid leukemia and lymphoma for five years: a first representative index of Japan from an epidemiologically stable Miyagi Prefecture. ( 27185073 )
2016
16
Synthesis and evaluation of the cytotoxic activity of novel ethyl 4-[4-(4-substitutedpiperidin-1-yl)]benzyl-phenylpyrrolo[1,2-a]quinoxaline-carboxylate derivatives in myeloid and lymphoid leukemia cell lines. ( 26945110 )
2016
17
Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. ( 26801976 )
2016
18
Leukemia-free survival in myeloid leukemia, but not in lymphoid leukemia, is predicted by early CD4+ reconstitution following unrelated cord blood transplantation in children: a multicenter retrospective cohort analysis. ( 27159172 )
2016
19
Correction: Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. ( 27197270 )
2016
20
Invasive fungal diseases in patients with acute lymphoid leukemia. ( 26949001 )
2016
21
Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia; Chimeric Antigen Receptor-Modified T Cells for Acute Lymphoid Leukemia; Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia. ( 26962747 )
2016
22
E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia. ( 27758892 )
2016
23
Phase II Trial of Reduced-Intensity Busulfan/Clofarabine Conditioning with Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Acute Lymphoid Leukemia. ( 26260679 )
2015
24
Acute oral complications in a pediatric patient with acute lymphoid leukemia. ( 26711327 )
2015
25
Role of Interleukin-10 Gene Promoter Region Polymorphism in the Development of Chronic Lymphoid Leukemia. ( 26642793 )
2015
26
Clinico-hematological profile of patients with B-chronic lymphoid leukemia in Pakistan. ( 25684527 )
2015
27
[Association between polymorphism of RAD50 gene and acute lymphoid leukemia in children]. ( 26014697 )
2015
28
Associations between genetic variants in folate and drug metabolizing pathways and relapse risk in pediatric acute lymphoid leukemia on CCG-1952. ( 26605150 )
2015
29
T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report. ( 25663889 )
2015
30
Transcription factor networks in B-cell differentiation link development to acute lymphoid leukemia. ( 25990863 )
2015
31
Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia. ( 26337639 )
2015
32
ZAP-70 protein expression in B-cell chronic lymphoid leukemia: a single center experience from Pakistan. ( 25743836 )
2015
33
Chemotherapy Exposure and outcomes Among Patients Diagnosed with Chronic Lymphoid Leukemia. ( 26532698 )
2015
34
Panniculitis in Patients Undergoing Treatment With the Bruton Tyrosine Kinase Inhibitor Ibrutinib for Lymphoid Leukemias. ( 26182170 )
2015
35
Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A. ( 26298709 )
2015
36
Direct Coombs Test Positivity in B-Chronic Lymphoid Leukemia: a Marker of Advanced Clinical Disease. ( 26320488 )
2015
37
Serum 25-hydroxyvitamin D Insufficiency in B-Chronic Lymphoid Leukemia at the Time of Disease Presentation in Pakistan. ( 26320484 )
2015
38
Neutralization of (NK-cell-derived) B-cell activating factor by Belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and Rituximab-induced NK lysis. ( 25710310 )
2015
39
Changes in the treatment landscape for chronic lymphoid leukemia. ( 25014693 )
2014
40
Acute lymphoid leukemia cells with greater stem cell antigen-1 (Ly6a/Sca-1) expression exhibit higher levels of metalloproteinase activity and are more aggressive in vivo. ( 24586463 )
2014
41
A Pilot Study for the Detection of FLT3-ITD Mutation Frequency in 25 Iraqi Patients With Acute Lymphoid Leukemia in 2 Iraqi Hospitals. ( 24390456 )
2014
42
Correlation between FDG/PET, histology, characteristics, and survival in 332 patients with chronic lymphoid leukemia. ( 24615780 )
2014
43
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia. ( 24881631 )
2014
44
Evaluation of selected honey and one of its phenolic constituent eugenol against L1210 lymphoid leukemia. ( 25506620 )
2014
45
Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. ( 25064348 )
2014
46
Endothelial Health in Childhood Acute Lymphoid Leukemia Survivors: Pilot Evaluation With Peripheral Artery Tonometry. ( 24577544 )
2014
47
Clofarabine for the treatment of Adult Acute Lymphoid Leukemia A review article by the GRAALL intergroup. ( 24996442 )
2014
48
Identification of GPM6A and GPM6B as potential new human lymphoid leukemia-associated oncogenes. ( 24916915 )
2014
49
Normalization of lymphocyte count after high ablative dose of I-131 in a patient with chronic lymphoid leukemia and secondary papillary carcinoma of the thyroid. Case report. ( 24728254 )
2014
50
Viability and stress protection of chronic lymphoid leukemia cells involves overactivation of mitochondrial phosphoSTAT3Ser727. ( 25299776 )
2014

Variations for Lymphoid Leukemia

Expression for Lymphoid Leukemia

Search GEO for disease gene expression data for Lymphoid Leukemia.

Pathways for Lymphoid Leukemia

Pathways related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.65 RUNX1 RUNX1T1 ZAP70
2 11.19 ETV6 KMT2A RUNX1 RUNX1T1

GO Terms for Lymphoid Leukemia

Cellular components related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.17 BCR ETV6 KMT2A NCKIPSD RUNX1 SH3GL1

Biological processes related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of megakaryocyte differentiation GO:0045652 9.16 KMT2A RUNX1
2 definitive hemopoiesis GO:0060216 8.96 BCR KMT2A
3 hematopoietic stem cell proliferation GO:0071425 8.62 ETV6 RUNX1

Molecular functions related to Lymphoid Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.28 BCR CD5 ETV6 KMT2A NCKIPSD RUNX1
2 DNA binding transcription factor activity GO:0003700 9.26 ETV6 KMT2A RUNX1 RUNX1T1

Sources for Lymphoid Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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