MCID: LYM104
MIFTS: 46

Lymphoma, Malt, Somatic malady

Categories: Genetic diseases, Blood diseases, Cancer diseases, Rare diseases, Immune diseases

Aliases & Classifications for Lymphoma, Malt, Somatic

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Sources:
49OMIM, 32LifeMap Discovery®, 10Disease Ontology, 11diseasecard, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 28ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lymphoma, Malt, Somatic:

Name: Lymphoma, Malt, Somatic 49 11
Malt Lymphoma 32 10 47 12 51
Mucosa-Associated Lymphoid Tissue Lymphoma 10 51 65
 
Extranodal Marginal Zone B-Cell Lymphoma 51 65
Mucosa-Associated Lymphatic Tissue Lymphoma 51
Maltoma 51

Characteristics:

Orphanet epidemiological data:

51
malt lymphoma:
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (United States),1-9/100000 (Europe); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

OMIM49 137245
Disease Ontology10 DOID:0050909
Orphanet51 52417
ICD10 via Orphanet28 C88.4
UMLS65 C0242647, C1955690

Summaries for Lymphoma, Malt, Somatic

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OMIM:49 The concept of mucosa-associated lymphoid tissue (MALT) lymphomas was introduced by Isaacson and Wright (1983). MALT... (137245) more...

MalaCards based summary: Lymphoma, Malt, Somatic, also known as malt lymphoma, is related to marginal zone b-cell lymphoma and lymphomatoid granulomatosis, and has symptoms including hyperhidrosis, weight loss and nausea and vomiting. An important gene associated with Lymphoma, Malt, Somatic is BCL10 (B-Cell CLL/Lymphoma 10), and among its related pathways are TCR signaling in naive CD4+ T cells and C-MYB transcription factor network. Affiliated tissues include b cells, thyroid and eye, and related mouse phenotypes are cellular and immune system.

Disease Ontology:10 A non-Hodgkin lymphoma that has material basis in mucosal tissue involved in antibody production.

Related Diseases for Lymphoma, Malt, Somatic

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Diseases related to Lymphoma, Malt, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 413)
idRelated DiseaseScoreTop Affiliating Genes
1marginal zone b-cell lymphoma32.6BCL2, CCND1, CD40, CD5, CXCR5, DUSP5
2lymphomatoid granulomatosis30.6BCL2, CCND1
3dilated cardiomyopathy29.9BCL10, BCL2, BCL6, CARD11, CD5, FOXP1
4primary cutaneous gamma/delta-positive t-cell lymphoma10.5BCL10, MALT1
5pancreatitis10.5
6plasmacytoma10.4BCL2, CCND1
7methotrexate-associated lymphoproliferation10.4CCND1, CD5
8monocular esotropia10.4BIRC3, CD5, MALT1
9parotid gland cancer10.4BCL10, CD5
10gastroduodenitis10.4MALT1, S100A8
11hepatitis10.4
12sarcoma10.4
13sternum lymphoma10.4BCL6, CD5, MALT1
14chromosome 1, uniparental disomy 1q12 q2110.4BCL10, MALT1
15bleeding diathesis due to integrin alpha2-beta1 deficiency10.4BCL2, BCL6, CD5
16leukemia10.3
17endotheliitis10.3
18cell type benign neoplasm10.3BCL6, CCND1, CD5
19central pontine myelinolysis10.3CCND1, CD5
20breast cancer10.3
21lymphoma10.3
22retinitis10.3
23neuronitis10.3
24lupus erythematosus10.3
25microinvasive gastric cancer10.3BCL10, BCL6, MALT1, S100A8
26arthritis10.2
27adenocarcinoma10.2
28thyroiditis10.2
29meningitis10.2
30cell type cancer10.2BCL6, CCND1, CD5
31bard1-related susceptibility to breast cancer10.2BCL10, BCL6, BIRC3, CXCR3, MALT1
32systemic lupus erythematosus10.2
33osteoarthritis10.2
34hepatitis c10.2
35cerebritis10.2
36myeloid leukemia10.2
37cardiomyopathy10.2
38ischemic heart disease10.2BCL2, CXCR5
39urinary bladder small cell neuroendocrine carcinoma10.1CCND1, CD5
40rheumatoid arthritis10.1
41colorectal cancer10.1
42lung cancer10.1
43prostate cancer10.1
44hepatocellular carcinoma10.1
45obesity10.1
46pancreatic cancer10.1
47glomerulonephritis10.1
48prostatitis10.1
49vulvovaginitis10.1
50psoriasis10.1

Graphical network of the top 20 diseases related to Lymphoma, Malt, Somatic:



Diseases related to lymphoma, malt, somatic

Symptoms for Lymphoma, Malt, Somatic

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Clinical features from OMIM:

137245

Symptoms:

 51 (show all 16)
  • hyperhidrosis/increased sweating
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • lung/pulmonary infiltrates
  • hematologic/blood/lymphatic cancer
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • fever/chilling
  • asthenia/fatigue/weakness
  • constipation
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • defect/anomaly of lacrimal system
  • acute abdominal pain/colic
  • mediastinal/hilar adenopathies
  • repeat respiratory infections
  • lymphadenopathy/polyadenopathies
  • thyroid anomalies

HPO human phenotypes related to Lymphoma, Malt, Somatic:

(show all 15)
id Description Frequency HPO Source Accession
1 hyperhidrosis hallmark (90%) HP:0000975
2 weight loss hallmark (90%) HP:0001824
3 nausea and vomiting hallmark (90%) HP:0002017
4 pulmonary infiltrates hallmark (90%) HP:0002113
5 abnormality of the gastric mucosa hallmark (90%) HP:0004295
6 abnormality of temperature regulation hallmark (90%) HP:0004370
7 hematological neoplasm hallmark (90%) HP:0004377
8 constipation typical (50%) HP:0002019
9 lacrimation abnormality occasional (7.5%) HP:0000632
10 abnormality of the thyroid gland occasional (7.5%) HP:0000820
11 abdominal pain occasional (7.5%) HP:0002027
12 recurrent respiratory infections occasional (7.5%) HP:0002205
13 inflammatory abnormality of the eye occasional (7.5%) HP:0100533
14 mediastinal lymphadenopathy occasional (7.5%) HP:0100721
15 gastric lymphoma HP:0045038

Drugs & Therapeutics for Lymphoma, Malt, Somatic

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Lymphoma, Malt, Somatic

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoma, Malt, Somatic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Lymphoma, Malt, Somatic:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Lymphoma, Malt, Somatic:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Lymphoma, Malt, Somatic

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Anatomical Context for Lymphoma, Malt, Somatic

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MalaCards organs/tissues related to Lymphoma, Malt, Somatic:

33
B cells, Thyroid, Eye, Bone, Lung

Animal Models for Lymphoma, Malt, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Lymphoma, Malt, Somatic:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.2BCL10, BCL2, BCL6, BIRC2, BIRC3, CCND1
2MP:00053877.5BCL10, BCL2, BCL6, BIRC2, BIRC3, CARD11
3MP:00053977.4BCL10, BCL2, BCL6, BIRC2, BIRC3, CARD11

Publications for Lymphoma, Malt, Somatic

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Variations for Lymphoma, Malt, Somatic

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Expression for genes affiliated with Lymphoma, Malt, Somatic

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Search GEO for disease gene expression data for Lymphoma, Malt, Somatic.

Pathways for genes affiliated with Lymphoma, Malt, Somatic

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Pathways related to Lymphoma, Malt, Somatic according to GeneCards Suite gene sharing:

(show all 26)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.0BCL10, CARD11, MALT1
210.0BCL2, BIRC3, CCND1
39.9BCL2, BCL6, CCND1
49.9BCL10, BIRC2, MALT1
59.9BCL2, CCND1, DUSP5
69.8BCL2, BIRC3, TRAF2
7
Show member pathways
9.8BCL10, CARD11, CD40, MALT1
89.8BCL10, BCL2, HSPD1, MALT1
99.7BIRC2, BIRC3, TRAF2
10
Show member pathways
9.6BCL2, BIRC2, BIRC3, CD40
119.6BCL6, CD40, CD5, CXCR5
12
Show member pathways
9.6BIRC2, CXCL13, TRAF2
13
Show member pathways
9.6BIRC2, CXCL13, TRAF2
14
Show member pathways
9.5BCL10, CARD11, CD40, MALT1, TRAF2
15
Show member pathways
9.5BCL2, BIRC2, BIRC3, TRAF2
16
Show member pathways
9.5BCL2, BIRC2, BIRC3, TRAF2
17
Show member pathways
9.5BCL2, BIRC2, BIRC3, TRAF2
18
Show member pathways
9.5BCL2, BIRC2, BIRC3, TRAF2
199.5BIRC2, BIRC3, CD40, TRAF2
20
Show member pathways
9.5BIRC2, BIRC3, CD40, TRAF2
219.3BCL2, BIRC2, BIRC3, CCND1, TRAF2
229.3BCL2, BIRC2, BIRC3, CCND1, TRAF2
23
Show member pathways
9.3BCL2, BIRC2, BIRC3, CD40, TRAF2
24
Show member pathways
9.3BCL2, BIRC2, BIRC3, CD40, TRAF2
259.3BCL6, CD40, CXCL13, CXCR5, MADCAM1
268.9BCL10, BCL2, BIRC2, BIRC3, CARD11, CD40

GO Terms for genes affiliated with Lymphoma, Malt, Somatic

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Biological processes related to Lymphoma, Malt, Somatic according to GeneCards Suite gene sharing:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1cellular response to organic substanceGO:007131010.6BCL2, CCND1
2positive regulation of T cell cytokine productionGO:000272610.6MALT1, TRAF2
3response to iron ionGO:001003910.6BCL2, CCND1
4positive regulation of interleukin-12 productionGO:003273510.6CD40, HSPD1
5regulation of cysteine-type endopeptidase activityGO:200011610.6BIRC2, BIRC3
6regulation of necroptotic processGO:006054410.6BIRC2, BIRC3
7regulation of RIG-I signaling pathwayGO:003953510.6BIRC2, BIRC3
8regulation of toll-like receptor signaling pathwayGO:003412110.6BIRC2, BIRC3
9regulation of immunoglobulin secretionGO:005102310.6CD40, TRAF2
10regulation of nucleotide-binding oligomerization domain containing signaling pathwayGO:007042410.6BIRC2, BIRC3
11regulation of innate immune responseGO:004508810.5BIRC2, BIRC3
12intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGO:007005910.4BCL2, TRAF2
13B cell proliferationGO:004210010.4BCL2, CD40, HSPD1
14B cell activationGO:004211310.4CD40, HSPD1
15positive regulation of protein ubiquitinationGO:003139810.4BCL10, BIRC3, MALT1
16necroptotic processGO:007026610.3BIRC2, BIRC3
17positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.2BCL10, BIRC3, CARD11, MALT1
18regulation of immune responseGO:005077610.1BCL6, CARD11, CD40, MADCAM1
19positive regulation of T cell activationGO:005087010.0CARD11, HSPD1, MALT1, TRAF2
20programmed cell deathGO:00125019.8BCL2, BIRC2, BIRC3, TRAF2
21I-kappaB kinase/NF-kappaB signalingGO:00072499.8BCL10, BIRC2, BIRC3, TRAF2
22tumor necrosis factor-mediated signaling pathwayGO:00332099.7BIRC2, BIRC3, CD40, TRAF2
23regulation of cell proliferationGO:00421279.7BCL6, BIRC2, CD40
24protein heterooligomerizationGO:00512919.7BCL10, BIRC2, BIRC3, TRAF2
25positive regulation of NF-kappaB transcription factor activityGO:00510929.6BCL10, CARD11, MALT1, S100A8, TRAF2
26negative regulation of apoptotic processGO:00430669.0BCL2, BCL6, BIRC2, BIRC3, HSPD1, MALT1

Sources for Lymphoma, Malt, Somatic

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet