MCID: LYM104
MIFTS: 36

Lymphoma, Malt, Somatic malady

Blood, Cancer, Immune categories

Summaries for Lymphoma, Malt, Somatic

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47OMIM, 33MalaCards
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MalaCards: Lymphoma, Malt, Somatic, also known as mucosa-associated lymphatic tissue lymphoma, is related to gastric lymphoma and follicular lymphoma, and has symptoms including nausea/vomiting/regurgitation/merycism/hyperemesis, hyperhidrosis/increased sweating and constipation. An important gene associated with Lymphoma, Malt, Somatic is BCL10 (B-cell CLL/lymphoma 10), and among its related pathways are NF-kappaB Signaling and Lymphocyte Signaling. The compound guanylate have been mentioned in the context of this disorder. Affiliated tissues include t cells and b cells, and related mouse phenotypes are immune system and hematopoietic system.

Description from OMIM:47 137245

Aliases & Classifications for Lymphoma, Malt, Somatic

Sources:
47OMIM, 49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
mucosa-associated lymphatic tissue lymphoma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

lymphoma, malt, somatic 47
mucosa-associated lymphatic tissue lymphoma 49
mucosa-associated lymphoid tissue lymphoma 49
extranodal marginal zone b-cell lymphoma 49
malt lymphoma 49
maltoma 49


External Ids:

OMIM47 137245
ICD10 via Orphanet26 C88.4

Related Diseases for Lymphoma, Malt, Somatic

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphoma, Malt, Somatic via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1gastric lymphoma31.7BCL10, MALT1, IGH
2follicular lymphoma30.8BCL10, BIRC3, IGH
3t-cell leukemia30.7BIRC3, IGH
4burkitt's lymphoma30.4IGH, BIRC3
5gallbladder lymphoma30.3BCL10, MALT1
6b-cell lymphomas30.3BCL10, BIRC3, MALT1, FOXP1, IGH
7lymphoma, diffuse large cell10.7
8thyroid lymphoma10.7
9gastrointestinal lymphoma10.6
10colon lymphoma10.6
11adenocarcinoma10.6
12orbit lymphoma10.6
13breast lymphoma10.6
14h. pylori infection10.5
15rectum lymphoma10.5
16central nervous system lymphoma10.5
17lateral ventricle meningioma10.5
18composite lymphoma10.5
19squamous cell carcinoma10.5
20central nervous system lymphoma, primary10.5
21leukemia/lymphoma, t-cell10.5
22lymphoproliferative syndrome 110.5
23bladder lymphoma10.4
24diffuse large b-cell lymphoma10.4
25thyroiditis10.4
26esophagus lymphoma10.4
27lung lymphoma10.4
28mantle cell lymphoma10.4
29lymphoma, somatic10.4
30lymphoid interstitial pneumonia10.3
31somatostatinoma10.3
32pancreatic somatostatinoma10.3
33polyclonal hypergammaglobulinemia10.3
34dyspepsia10.3
35adenoma10.3
36allergic conjunctivitis10.3
37thymus lymphoma10.3
38sjogren's syndrome10.3
39systemic lupus erythematosus10.3
40gastric ulcer10.3
41bone lymphoma10.3
42small intestine lymphoma10.3
43primary pulmonary lymphoma10.3
44cryoglobulinemia10.2
45cecum lymphoma10.2
46macroglobulinemia10.2
47liver lymphoma10.2
48extramedullary plasmacytoma10.2
49lymphoplasmacytic lymphoma10.2
50n syndrome10.2

Graphical network of the top 20 diseases related to Lymphoma, Malt, Somatic:



Diseases related to lymphoma, malt, somatic

Clinical Features for Lymphoma, Malt, Somatic

Sources:
47OMIM, 49Orphanet
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Clinical features from OMIM:

137245

Symptoms:

49 (show all 16)
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • hyperhidrosis/increased sweating
  • constipation
  • repeat respiratory infections
  • asthenia/fatigue/weakness
  • fever/chilling
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • acute abdominal pain/colic
  • lung/pulmonary infiltrates
  • defect/anomaly of lacrimal system
  • epigastralgia/heartburn/gastric/duodenal ulcer/gastritis
  • thyroid anomalies
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • mediastinal/hilar adenopathies
  • lymphadenopathy/polyadenopathies
  • hematologic/blood/lymphatic cancer

Drugs & Therapeutics for Lymphoma, Malt, Somatic

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Lymphoma, Malt, Somatic

Anatomical Context for Lymphoma, Malt, Somatic

Sources:
33MalaCards
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MalaCards organs/tissues related to Lymphoma, Malt, Somatic:

33
T cells, B cells

Animal Models for Lymphoma, Malt, Somatic or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Lymphoma, Malt, Somatic:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4BCL10, BIRC3, MALT1, FOXP1
2MP:00053978.1BCL10, BIRC3, MALT1, FOXP1

Publications for Lymphoma, Malt, Somatic

Sources:
51PubMed
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Articles related to Lymphoma, Malt, Somatic:

idTitleAuthorsYear
1
Distinct involvement of NF-I_B regulators by somatic mutation in ocular adnexal malt lymphoma. (23240725)
2013
2
MYD88 somatic mutations in MALT lymphomas. (22640364)
2012
3
Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins. (19965661)
2010
4
MALT lymphoma and extranodal diffuse large B-cell lymphoma are targeted by aberrant somatic hypermutation. (17197434)
2007
5
Infrequent somatic Fas mutations but no evidence of Bcl10 mutations or t(11;18) in primary cutaneous MALT-type lymphoma. (12950026)
2003
6
Somatic hypermutation of immunoglobulin heavy chain variable region genes in thymic marginal zone B-cell lymphoma of MALT type of a patient with SjAPgren's syndrome. (11895498)
2002

Genetic Variations for Lymphoma, Malt, Somatic

Expression for genes affiliated with Lymphoma, Malt, Somatic

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphoma, Malt, Somatic

Search GEO for disease gene expression data for Lymphoma, Malt, Somatic.

Pathways for genes affiliated with Lymphoma, Malt, Somatic

Sources:
4Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 56SinoBiological, 53R&D Systems
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Compounds for genes affiliated with Lymphoma, Malt, Somatic

Sources:
45Novoseek
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Compounds related to Lymphoma, Malt, Somatic according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1guanylate459.4BCL10, MALT1

GO Terms for genes affiliated with Lymphoma, Malt, Somatic

Sources:
16Gene Ontology
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Cellular components related to Lymphoma, Malt, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CBM complexGO:0324499.4BCL10, MALT1

Biological processes related to Lymphoma, Malt, Somatic according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:0508569.7BCL10, MALT1
2response to fungusGO:0096209.6BCL10, MALT1
3response to molecule of bacterial originGO:0022379.6BCL10, MALT1
4positive regulation of T cell activationGO:0508709.6BCL10, MALT1
5protein oligomerizationGO:0512599.5BCL10, MALT1
6positive regulation of protein ubiquitinationGO:0313989.5MALT1, BCL10
7T cell receptor signaling pathwayGO:0508529.4BCL10, MALT1
8Fc-epsilon receptor signaling pathwayGO:0380959.4BCL10, MALT1
9positive regulation of NF-kappaB transcription factor activityGO:0510929.3MALT1, BCL10
10toll-like receptor signaling pathwayGO:0022249.2BIRC3, BCL10
11positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.1MALT1, BIRC3, BCL10
12innate immune responseGO:0450878.9BCL10, BIRC3, MALT1

Molecular functions related to Lymphoma, Malt, Somatic according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.4BCL10, MALT1
2kinase activator activityGO:0192099.3BCL10, MALT1
3protein self-associationGO:0436219.1BCL10, MALT1

Products for genes affiliated with Lymphoma, Malt, Somatic

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphoma, Malt, Somatic

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet