MCID: LYM104
MIFTS: 44

Lymphoma, Malt, Somatic malady

Categories: Genetic diseases, Blood diseases, Rare diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Lymphoma, Malt, Somatic

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Sources:
50OMIM, 12diseasecard, 33LifeMap Discovery®, 11Disease Ontology, 13DISEASES, 52Orphanet, 48Novoseek, 66UMLS, 29ICD10 via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lymphoma, Malt, Somatic:

Name: Lymphoma, Malt, Somatic 50 12
Malt Lymphoma 33 11 13 52 48
Mucosa-Associated Lymphoid Tissue Lymphoma 11 52 66
Mucosa-Associated Lymphatic Tissue Lymphoma 52
 
Lymphoma, Mucosa-Associated Lymphoid Type 50
Extranodal Marginal Zone B-Cell Lymphoma 52
Maltoma 52

Characteristics:

Orphanet epidemiological data:

52
malt lymphoma:
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (Europe),1-9/100000 (United States),1-9/100000 (Europe); Age of onset: Adult; Age of death: normal life expectancy

Classifications:



External Ids:

OMIM50 137245
Disease Ontology11 DOID:0050909
Orphanet52 ORPHA52417
ICD10 via Orphanet29 C88.4

Summaries for Lymphoma, Malt, Somatic

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OMIM:50 The concept of mucosa-associated lymphoid tissue (MALT) lymphomas was introduced by Isaacson and Wright (1983). MALT... (137245) more...

MalaCards based summary: Lymphoma, Malt, Somatic, also known as malt lymphoma, is related to gastric cancer and lymphoma, and has symptoms including hyperhidrosis, weight loss and nausea and vomiting. An important gene associated with Lymphoma, Malt, Somatic is BCL10 (B-Cell CLL/Lymphoma 10), and among its related pathways are TCR signaling in naive CD4+ T cells and Canonical NF-kappaB pathway. Affiliated tissues include b cells, thyroid and bone, and related mouse phenotypes are cellular and immune system.

Disease Ontology:11 A non-hodgkin lymphoma that has material basis in mucosal tissue involved in antibody production.

Related Diseases for Lymphoma, Malt, Somatic

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Diseases related to Lymphoma, Malt, Somatic via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1gastric cancer30.7BCL6, CCND1, CD40, MME
2lymphoma11.1
3raynaud disease10.7BIRC3, CD5, MALT1
4acute motor axonal neuropathy10.6BCL6, CD5, MME
5leukoencephalopathy palmoplantar keratoderma10.6BCL10, CCND1, IGH
6lung cancer susceptibility 410.6BCL6, IGH
7teebi kaurah syndrome10.5BCL6, IGH, MME
8trachea squamous cell carcinoma10.5CD5, MME
9gray zone lymphoma10.5CCND1, CD5, MME
10b-cell lymphomas10.5
11primary cutaneous unspecified peripheral t-cell lymphoma10.5BCL6, MALT1
12acral lentiginous melanoma10.5CCND1, CD5, MME
13polyembryoma of the ovary10.5BCL6, CD5, MALT1
14primary cutaneous cd4+ small/medium-sized pleomorphic t-cell lymphoma10.5BCL10, MALT1
15multicentric reticulohistiocytosis10.4CD5, MME
16diffuse large b-cell lymphoma10.4
17lipid-rich breast carcinoma10.4BCL6, CD40, MME
18hemolytic anemia10.4BCL6, CCND1, CD5, MME
19organ system benign neoplasm10.4BCL6, CCND1, CD5, MME
20thyroiditis10.4
21bartter syndrome type 4b, clcnka/clcnkb digenic10.4BCL10, BCL6, BIRC3, CXCR3, MALT1
22marginal zone b-cell lymphoma10.4
23brachyolmia10.3BCL6, CCND1, CD5, MME
24adenocarcinoma10.3
25b-cell lymphoma of mucosa-associated lymphoid tissue10.2
26spastic paraplegia 8, autosomal dominant10.2BCL6, CD40, CXCL13, CXCR5
27inherited metabolic disorder10.1BCL6, MME
28hepatitis10.1
29chlamydia10.1
30gastric adenocarcinoma10.1
31gastritis10.1
32duodenitis10.1
33follicular lymphoma10.0
34mantle cell lymphoma10.0
35melanoma metastasis10.0BCL10, BCL6, BIRC3, CCND1, CD5, MALT1
36pyridoxine-responsive sideroblastic anemia10.0BCL10, BCL6, CCND1, CXCL13, CXCR5, MALT1
37systemic lupus erythematosus10.0
38hodgkin lymphoma10.0
39plasmacytoma10.0
40lupus erythematosus10.0
41macroglobulinemia10.0
42rheumatoid arthritis9.9
43h. pylori infection9.9
44arthritis9.9
45ulcerative colitis9.9
46lymphoplasmacytic lymphoma9.9
47colitis9.9
48sjogren's syndrome9.9
49obstructive jaundice9.9
50melanoma9.9

Graphical network of the top 20 diseases related to Lymphoma, Malt, Somatic:



Diseases related to lymphoma, malt, somatic

Symptoms for Lymphoma, Malt, Somatic

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Clinical features from OMIM:

137245

Symptoms:

 52 (show all 17)
  • visual impairment
  • abnormality of the nasolacrimal system
  • abnormality of the thyroid gland
  • weight loss
  • anemia
  • fever
  • nausea and vomiting
  • abdominal pain
  • pulmonary infiltrates
  • recurrent respiratory infections
  • lymphadenopathy
  • b-cell lymphoma
  • fatigue
  • mediastinal lymphadenopathy
  • hyperhidrosis
  • constipation
  • posterior uveitis

HPO human phenotypes related to Lymphoma, Malt, Somatic:

(show all 15)
id Description Frequency HPO Source Accession
1 hyperhidrosis hallmark (90%) HP:0000975
2 weight loss hallmark (90%) HP:0001824
3 nausea and vomiting hallmark (90%) HP:0002017
4 pulmonary infiltrates hallmark (90%) HP:0002113
5 abnormality of the gastric mucosa hallmark (90%) HP:0004295
6 abnormality of temperature regulation hallmark (90%) HP:0004370
7 hematological neoplasm hallmark (90%) HP:0004377
8 constipation typical (50%) HP:0002019
9 lacrimation abnormality occasional (7.5%) HP:0000632
10 abnormality of the thyroid gland occasional (7.5%) HP:0000820
11 abdominal pain occasional (7.5%) HP:0002027
12 recurrent respiratory infections occasional (7.5%) HP:0002205
13 inflammatory abnormality of the eye occasional (7.5%) HP:0100533
14 mediastinal lymphadenopathy occasional (7.5%) HP:0100721
15 gastric lymphoma HP:0045038

Drugs & Therapeutics for Lymphoma, Malt, Somatic

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Lymphoma, Malt, Somatic

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Lymphoma, Malt, Somatic cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Lymphoma, Malt, Somatic:
Hematopoietic stem cells for treatment of hematologic malignancies
Embryonic/Adult Cultured Cells Related to Lymphoma, Malt, Somatic:
Bone marrow-derived hematopoietic stem cells

Genetic Tests for Lymphoma, Malt, Somatic

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Anatomical Context for Lymphoma, Malt, Somatic

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MalaCards organs/tissues related to Lymphoma, Malt, Somatic:

34
B cells, Thyroid, Bone, Eye

Animal Models for Lymphoma, Malt, Somatic or affiliated genes

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MGI Mouse Phenotypes related to Lymphoma, Malt, Somatic:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.4BCL10, BCL6, BIRC2, BIRC3, CCND1, CXCL13
2MP:00053877.8BCL10, BCL6, BIRC2, BIRC3, CARD11, CCND1
3MP:00053977.6BCL10, BCL6, BIRC2, BIRC3, CARD11, CCND1

Publications for Lymphoma, Malt, Somatic

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Variations for Lymphoma, Malt, Somatic

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Cosmic variations for Lymphoma, Malt, Somatic:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM85940MYD88haematopoietic and lymphoid tissue,extranodal,lymphoid neoplasm,MALT lymphomac.794T>Cp.L265P0
2COSM36072NOTCH2haematopoietic and lymphoid tissue,extranodal,lymphoid neoplasm,MALT lymphomac.4912C>Tp.H1638Y0

Copy number variations for Lymphoma, Malt, Somatic from CNVD:

6
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1119732181610000076117153GainMALT1Mucosa-associated lymphoid tissue lymphomas
22060106135101251139048099LossTNFAIP3Mucosa-associated lymphoid tissue lymphomas

Expression for genes affiliated with Lymphoma, Malt, Somatic

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Search GEO for disease gene expression data for Lymphoma, Malt, Somatic.

Pathways for genes affiliated with Lymphoma, Malt, Somatic

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Pathways related to Lymphoma, Malt, Somatic according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
10.0BCL10, CARD11, MALT1
29.9BCL10, BIRC2, MALT1
3
Show member pathways
9.8BCL10, CARD11, CD40, MALT1
4
Show member pathways
9.8BCL10, BCL6, CARD11, CD5
59.7BIRC2, BIRC3, TRAF2
6
Show member pathways
9.7BCL10, CARD11, CD40, IGH, MALT1
7
Show member pathways
9.6BIRC2, CXCL13, TRAF2
89.5BIRC2, BIRC3, CCND1, TRAF2
9
Show member pathways
9.5BIRC2, BIRC3, CD40, TRAF2
109.5BIRC2, BIRC3, CD40, TRAF2
11
Show member pathways
9.5BCL10, CARD11, CD40, MALT1, TRAF2
129.4BCL10, BIRC2, BIRC3, MALT1, TRAF2
139.4BCL6, CD40, CD5, CXCR5, MME
149.3BCL10, BCL6, CARD11, MALT1, MME, TRAF2
159.3BCL6, CD40, CXCL13, CXCR5, MADCAM1
169.0BCL10, BIRC2, BIRC3, CARD11, CD40, MALT1

GO Terms for genes affiliated with Lymphoma, Malt, Somatic

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Cellular components related to Lymphoma, Malt, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1CBM complexGO:003244910.8BCL10, MALT1
2lipopolysaccharide receptor complexGO:004669610.7BCL10, HSPD1
3T cell receptor complexGO:004210110.7BCL10, CARD11
4CD40 receptor complexGO:00356319.9BIRC2, CD40, TRAF2
5external side of plasma membraneGO:00098979.9CD40, CD5, CXCR3, CXCR5
6protein complexGO:00432349.2BCL10, BIRC2, BIRC3, HSPD1, MALT1, TRAF2
7membrane raftGO:00451218.9BCL10, BIRC2, BIRC3, CARD11, HSPD1, TRAF2

Biological processes related to Lymphoma, Malt, Somatic according to GeneCards Suite gene sharing:

(show all 41)
idNameGO IDScoreTop Affiliating Genes
1regulation of T cell receptor signaling pathwayGO:005085610.8BCL10, MALT1
2negative regulation of B cell apoptotic processGO:000290310.8BCL6, FOXP1
3response to fungusGO:000962010.8BCL10, MALT1
4regulation of RIG-I signaling pathwayGO:003953510.7BIRC2, BIRC3
5regulation of toll-like receptor signaling pathwayGO:003412110.7BIRC2, BIRC3
6regulation of cysteine-type endopeptidase activityGO:200011610.7BIRC2, BIRC3
7regulation of nucleotide-binding oligomerization domain containing signaling pathwayGO:007042410.7BIRC2, BIRC3
8response to molecule of bacterial originGO:000223710.7BCL10, MALT1
9inhibition of cysteine-type endopeptidase activity involved in apoptotic processGO:199000110.7BIRC2, BIRC3
10positive regulation of T cell cytokine productionGO:000272610.7MALT1, TRAF2
11negative regulation of necroptotic processGO:006054610.7BIRC2, BIRC3
12positive regulation of interleukin-2 productionGO:003274310.6MALT1, TRAF2
13regulation of necroptotic processGO:006054410.6BIRC2, BIRC3
14activation of NF-kappaB-inducing kinase activityGO:000725010.6MALT1, TRAF2
15regulation of immunoglobulin secretionGO:005102310.6CD40, TRAF2
16stimulatory C-type lectin receptor signaling pathwayGO:000222310.6BCL10, CARD11, MALT1
17germinal center formationGO:000246710.5BCL6, CXCL13
18positive regulation of B cell proliferationGO:003089010.5BCL6, CARD11, CD40
19chronic inflammatory responseGO:000254410.5CXCL13, S100A8
20positive regulation of protein ubiquitinationGO:003139810.4BCL10, BIRC3, MALT1
21regulation of innate immune responseGO:004508810.4BIRC2, BIRC3
22regulation of necrotic cell deathGO:001093910.4BIRC2, BIRC3, TRAF2
23lymph node developmentGO:004853510.3CXCL13, CXCR5
24regulation of tumor necrosis factor-mediated signaling pathwayGO:001080310.2BIRC2, BIRC3, TRAF2
25I-kappaB kinase/NF-kappaB signalingGO:000724910.2BCL10, BIRC2, BIRC3, TRAF2
26positive regulation of T cell activationGO:005087010.1BCL10, CARD11, HSPD1, MALT1, TRAF2
27regulation of immune responseGO:005077610.1BCL6, CARD11, CD40, MADCAM1
28tumor necrosis factor-mediated signaling pathwayGO:003320910.1BIRC2, BIRC3, CD40, TRAF2
29chemokine-mediated signaling pathwayGO:007009810.1CXCL13, CXCR3, CXCR5
30protein heterooligomerizationGO:005129110.0BCL10, BIRC2, BIRC3, TRAF2
31B cell activationGO:004211310.0CD40, CXCR5, HSPD1, MALT1
32activation of cysteine-type endopeptidase activity involved in apoptotic processGO:000691910.0HSPD1, S100A8, TRAF2
33regulation of inflammatory responseGO:00507279.7BCL6, BIRC2, BIRC3, FOXP1
34regulation of cell proliferationGO:00421279.7BCL6, BIRC2, CD40, CXCL13
35inflammatory responseGO:00069549.7BCL6, CD40, CXCL13, CXCR3, S100A8
36positive regulation of NF-kappaB transcription factor activityGO:00510929.6BCL10, CARD11, CD40, MALT1, S100A8, TRAF2
37cell surface receptor signaling pathwayGO:00071669.5BIRC2, BIRC3, CXCL13, CXCR3
38response to lipopolysaccharideGO:00324969.5CD40, CXCL13, FOXP1, HSPD1, S100A8
39positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.5BCL10, BIRC2, BIRC3, CARD11, CD40, MALT1
40regulation of apoptotic processGO:00429819.5BCL6, BIRC2, BIRC3, CARD11, MALT1, TRAF2
41negative regulation of apoptotic processGO:00430669.4BCL6, BIRC2, BIRC3, HSPD1, MALT1

Molecular functions related to Lymphoma, Malt, Somatic according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinase activator activityGO:001920910.7BCL10, MALT1
2protein self-associationGO:004362110.4BCL10, FOXP1, MALT1
3C-X-C chemokine receptor activityGO:001649410.1CXCR3, CXCR5
4protease bindingGO:000202010.0BCL10, HSPD1, MALT1
5ubiquitin protein ligase bindingGO:00316259.3BCL10, CD40, HSPD1, TRAF2

Sources for Lymphoma, Malt, Somatic

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet