MCID: LYM115
MIFTS: 51

Lymphoma, Non-Hodgkin malady

Genetic diseases (common), Cancer diseases, Immune diseases categories

Summaries for Lymphoma, Non-Hodgkin

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Wikipedia:65 The non-Hodgkin lymphomas (NHLs) are diverse group of blood cancers that include any kind of lymphoma... more...

MalaCards based summary: Lymphoma, Non-Hodgkin, also known as non-hodgkin lymphoma, is related to colorectal cancer and b-cell lymphomas, and has symptoms including lymphoma An important gene associated with Lymphoma, Non-Hodgkin is RAD54L (RAD54-like (S. cerevisiae)), and among its related pathways are Homologous recombination and Meiosis. The compounds z-vad-fmk and o6-methylguanine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are tumorigenesis and immune system.

Disease Ontology:10 A lymphoma that is characterized as any kind of lymphoma except hodgkin's lymphoma.

Description from OMIM:47 605027

Aliases & Classifications for Lymphoma, Non-Hodgkin

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Lymphoma, Non-Hodgkin, Aliases & Descriptions:

Name: Lymphoma, Non-Hodgkin 47 11 32
Non-Hodgkin Lymphoma 32 10
Lymphoma, Non-Hodgkin, Somatic 47
 
Familial Non-Hodgkin Lymphoma 22
Non-Hodgkin Lymphoma, Somatic 47
Lymphoma Non-Hodgkins 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Immune diseases


External Ids:

OMIM47 605027
Disease Ontology10 DOID:0060060
ICD1027 C85.7

Related Diseases for Lymphoma, Non-Hodgkin

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Graphical network of the top 20 diseases related to Lymphoma, Non-Hodgkin:



Diseases related to lymphoma, non-hodgkin

Symptoms for Lymphoma, Non-Hodgkin

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Clinical features from OMIM:

605027

HPO human phenotypes related to Lymphoma, Non-Hodgkin:

id Description Frequency HPO Source Accession
1 lymphoma HP:0002665

Drugs & Therapeutics for Lymphoma, Non-Hodgkin

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Drug clinical trials:

Search ClinicalTrials for Lymphoma, Non-Hodgkin

Search NIH Clinical Center for Lymphoma, Non-Hodgkin

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphoma, Non-Hodgkin cell therapies at LifeMap Discovery.

Genetic Tests for Lymphoma, Non-Hodgkin

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Genetic tests related to Lymphoma, Non-Hodgkin:

id Genetic test Affiliating Genes
1 Familial Non-Hodgkin Lymphoma22

Anatomical Context for Lymphoma, Non-Hodgkin

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MalaCards organs/tissues related to Lymphoma, Non-Hodgkin:

33
Bone, Bone marrow, B cells

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Lymphoma, Non-Hodgkin:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Lymphoma, Non-Hodgkin or affiliated genes

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MGI Mouse Phenotypes related to Lymphoma, Non-Hodgkin:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2TP53, BRAF, PRF1
2MP:00053878.1RAD54L, PRF1, BRAF, TP53
3MP:00053977.8RAD54L, RAD54B, PRF1, BRAF, TP53
4MP:00053847.7TP53, BRAF, PRF1, RAD54B, RAD54L
5MP:00053767.6TP53, BRAF, PRF1, RAD54B, RAD54L
6MP:00107687.5RAD54L, RAD54B, PRF1, BRAF, TP53

Publications for Lymphoma, Non-Hodgkin

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Variations for Lymphoma, Non-Hodgkin

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UniProtKB/Swiss-Prot genetic disease variations for Lymphoma, Non-Hodgkin:

64
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly469AlaVAR_018620
2BRAFp.Gly469ArgVAR_018622
3BRAFp.Asp594GlyVAR_018624
4CASP10p.Ala414ValVAR_037430rs28936699

Clinvar genetic disease variations for Lymphoma, Non-Hodgkin:

7 (show all 11)
id Gene Variation Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.974G> T (p.Gly325Val)single nucleotide variantPathogenicrs121912659GRCh37Chr 17, 7576872: 7576872
2PRF1NM_001083116.1(PRF1): c.1122G> A (p.Trp374Ter)single nucleotide variantPathogenicrs104894176GRCh37Chr 10, 72358355: 72358355
3PRF1NM_001083116.1(PRF1): c.755A> G (p.Asn252Ser)single nucleotide variantPathogenicrs28933375GRCh37Chr 10, 72358722: 72358722
4BRAFNM_004333.4(BRAF): c.1405G> C (p.Gly469Arg)single nucleotide variantPathogenicrs121913357GRCh37Chr 7, 140481403: 140481403
5BRAFNM_004333.4(BRAF): c.1406G> C (p.Gly469Ala)single nucleotide variantPathogenicrs121913355GRCh37Chr 7, 140481402: 140481402
6BRAFNM_004333.4(BRAF): c.1781A> G (p.Asp594Gly)single nucleotide variantPathogenicrs121913338GRCh37Chr 7, 140453154: 140453154
7RAD54BNM_012415.3(RAD54B): c.1778A> G (p.Asn593Ser)single nucleotide variantPathogenicrs114216685GRCh37Chr 8, 95403868: 95403868
8RAD54LNM_001142548.1(RAD54L): c.1331T> A (p.Val444Glu)single nucleotide variantPathogenicrs121908689GRCh37Chr 1, 46738430: 46738430
9CASP10NM_032977.3(CASP10): c.1241C> T (p.Ala414Val)single nucleotide variantPathogenicrs28936699GRCh37Chr 2, 202074111: 202074111
10CASP10NM_032977.3(CASP10): c.769C> T (p.Gln257Ter)single nucleotide variantPathogenicrs121909775GRCh37Chr 2, 202070652: 202070652
11CASP10NM_032977.3(CASP10): c.1042_1043insA (p.Gly348Glufs)insertionPathogenicrs398122800GRCh37Chr 2, 202073912: 202073913

Expression for genes affiliated with Lymphoma, Non-Hodgkin

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Search GEO for disease gene expression data for Lymphoma, Non-Hodgkin.

Pathways for genes affiliated with Lymphoma, Non-Hodgkin

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Pathways related to Lymphoma, Non-Hodgkin according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Homologous recombination38
9.6RAD54B, RAD54L
29.6RAD54L, RAD54B
3
Show member pathways
9.4TP53, CASP10
49.4CASP10, TP53
5
Show member pathways
9.4CASP10, TP53
6
Show member pathways
9.4CASP10, TP53
7
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.4CASP10, TP53
8
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.4CASP10, TP53
9
Show member pathways
9.4CASP10, TP53
109.4CASP10, TP53
119.4TP53, CASP10
12
Show member pathways
9.3CASP10, PRF1
13
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.3PRF1, CASP10
14
Show member pathways
9.1BRAF, CASP10
15
Show member pathways
Signal transduction PTEN pathway60
9.1TP53, BRAF
16
Show member pathways
ErbB receptor signaling network38
ErbB signaling pathway38
9.1BRAF, TP53
179.1TP53, BRAF
18
Show member pathways
9.1TP53, BRAF
199.1BRAF, TP53
20
Show member pathways
9.1TP53, BRAF
21
Show member pathways
9.1BRAF, TP53
22
Show member pathways
9.1BRAF, TP53
239.1BRAF, TP53
249.1TP53, BRAF
259.1BRAF, TP53
26
Show member pathways
9.1BRAF, TP53
27
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
9.1TP53, BRAF
28
Show member pathways
Ras signaling in the CD4+ TCR pathway38
9.0PRF1, BRAF
29
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
8.8CASP10, PRF1, TP53
308.7RAD54L, BRAF, TP53
31
Show member pathways
8.6CASP10, BRAF, TP53
32
Show member pathways
8.6TP53, BRAF, CASP10

Compounds for genes affiliated with Lymphoma, Non-Hodgkin

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Compounds related to Lymphoma, Non-Hodgkin according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1z-vad-fmk45 6110.6CASP10, TP53
2o6-methylguanine459.3TP53, BRAF
3crcs459.2BRAF, TP53
4depsipeptide459.2BRAF, TP53
5geldanamycin45 51 61 1312.1BRAF, TP53
6irinotecan45 51 1310.8BRAF, TP53
7paclitaxel45 51 1310.8CASP10, BRAF, TP53
8cisplatin45 51 61 1311.6TP53, BRAF, CASP10
9serine457.9CASP10, PRF1, BRAF, TP53

GO Terms for genes affiliated with Lymphoma, Non-Hodgkin

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Biological processes related to Lymphoma, Non-Hodgkin according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA strand renaturationGO:00007339.5RAD54L, TP53
2double-strand break repair via homologous recombinationGO:00007249.5RAD54L, RAD54B
3regulation of apoptotic processGO:00429819.4CASP10, TP53
4apoptotic processGO:00069158.5CASP10, PRF1, TP53

Molecular functions related to Lymphoma, Non-Hodgkin according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:00316259.4CASP10, TP53
2ATP bindingGO:00055248.0RAD54L, RAD54B, BRAF, TP53

Products for genes affiliated with Lymphoma, Non-Hodgkin

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Sources for Lymphoma, Non-Hodgkin

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet