MCID: LYM115
MIFTS: 50

Lymphoma, Non-Hodgkin malady

Genetic diseases (common), Cancer diseases, Immune diseases categories

Summaries for Lymphoma, Non-Hodgkin

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Wikipedia:63 The non-Hodgkin lymphomas (NHLs) are diverse group of blood cancers that include any kind of lymphoma... more...

MalaCards based summary: Lymphoma, Non-Hodgkin, also known as non-hodgkin lymphoma, is related to b-cell lymphomas and cholangiocarcinoma, and has symptoms including lymphoma An important gene associated with Lymphoma, Non-Hodgkin is RAD54L (RAD54-like (S. cerevisiae)), and among its related pathways are Homologous recombination and Meiosis. The drugs carmustine and cisplatin and the compounds z-vad-fmk and o6-methylguanine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are tumorigenesis and immune system.

Disease Ontology:9 A lymphoma that is characterized as any kind of lymphoma except hodgkin's lymphoma.

Description from OMIM:45 605027

Aliases & Classifications for Lymphoma, Non-Hodgkin

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Lymphoma, Non-Hodgkin, Aliases & Descriptions:

Name: Lymphoma, Non-Hodgkin 45 10 30 60
Non-Hodgkin Lymphoma 30 9
Lymphoma, Non-Hodgkin, Somatic 45
 
Familial Non-Hodgkin Lymphoma 20
Non-Hodgkin Lymphoma, Somatic 45
Lymphoma Non-Hodgkins 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Cancer diseases
Anatomical: Immune diseases


External Ids:

OMIM45 605027
Disease Ontology9 DOID:0060060
ICD1025 C85.7

Related Diseases for Lymphoma, Non-Hodgkin

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Diseases related to Lymphoma, Non-Hodgkin via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1b-cell lymphomas30.2PRF1, TP53
2cholangiocarcinoma30.1BRAF, TP53
3colorectal cancer30.1BRAF, CASP10, TP53
4thyroid cancer30.1TP53, BRAF
5lung cancer30.0TP53, BRAF
6burkitt lymphoma29.9PRF1, CASP10, TP53
7melanoma29.5TP53, BRAF, CASP10, PRF1
8hepatitis10.8
9hodgkin lymphoma10.8
10chronic lymphocytic leukemia10.8
11mantle cell lymphoma10.7
12hepatitis c10.7
13hepatitis b10.6
14hematopoietic stem cell transplantation10.6
15progressive multifocal leukoencephalopathy10.5
16lymphoblastic leukemia10.5
17sarcoma10.5
18neutropenia10.5
19cryoglobulinemia10.5
20pneumonia10.5
21hepatitis c virus10.4
22hemolytic anemia10.4
23acquired immunodeficiency syndrome10.4
24autoimmune hemolytic anemia10.4
25obstructive jaundice10.4
26non-hodgkin lymphoma, during pregnancy10.4
27endotheliitis10.4
28renal cell carcinoma10.4
29acute leukemia10.4
30follicular lymphoma10.4
31meningitis10.4
32prostatitis10.4
33non-hodgkin lymphoma, childhood10.4
34hypoxia10.4
35endophthalmitis10.3PRF1
36breast cancer10.3
37kaposi sarcoma10.3
38aspergillosis10.3
39wiskott-aldrich syndrome10.3
40anaplastic large cell lymphoma10.3
41common variable immunodeficiency10.3
42glomerulonephritis10.3
43mycosis fungoides10.3
44sinusitis10.3
45langerhans-cell histiocytosis10.3
46pemphigus10.3
47intussusception10.3
48invasive aspergillosis10.3
49macroglobulinemia10.3
50lymphoplasmacytic lymphoma10.3

Graphical network of the top 20 diseases related to Lymphoma, Non-Hodgkin:



Diseases related to lymphoma, non-hodgkin

Symptoms for Lymphoma, Non-Hodgkin

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Clinical features from OMIM:

605027

HPO human phenotypes related to Lymphoma, Non-Hodgkin:

id Description Frequency HPO Source Accession
1 lymphoma HP:0002665

Drugs & Therapeutics for Lymphoma, Non-Hodgkin

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Genetic Tests for Lymphoma, Non-Hodgkin

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Genetic tests related to Lymphoma, Non-Hodgkin:

id Genetic test Affiliating Genes
1 Familial Non-Hodgkin Lymphoma20

Anatomical Context for Lymphoma, Non-Hodgkin

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MalaCards organs/tissues related to Lymphoma, Non-Hodgkin:

31
Bone, Bone marrow, B cells

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Lymphoma, Non-Hodgkin:
id TissueAnatomical CompartmentCell Relevance
1 BloodHematopoietic Bone MarrowHematopoietic Stem Cells Potential therapeutic candidate
2 BloodPeripheral BloodMature B-Cells Potential therapeutic candidate, affected by disease

Animal Models for Lymphoma, Non-Hodgkin or affiliated genes

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MGI Mouse Phenotypes related to Lymphoma, Non-Hodgkin:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2TP53, BRAF, PRF1
2MP:00053878.1RAD54L, PRF1, BRAF, TP53
3MP:00053977.8RAD54L, RAD54B, PRF1, BRAF, TP53
4MP:00053847.7TP53, BRAF, PRF1, RAD54B, RAD54L
5MP:00053767.6TP53, BRAF, PRF1, RAD54B, RAD54L
6MP:00107687.5RAD54L, RAD54B, PRF1, BRAF, TP53

Publications for Lymphoma, Non-Hodgkin

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Variations for Lymphoma, Non-Hodgkin

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UniProtKB/Swiss-Prot genetic disease variations for Lymphoma, Non-Hodgkin:

62
id Symbol AA change Variation ID SNP ID
1BRAFp.Gly469AlaVAR_018620
2BRAFp.Gly469ArgVAR_018622
3BRAFp.Asp594GlyVAR_018624
4CASP10p.Ala414ValVAR_037430rs28936699

Clinvar genetic disease variations for Lymphoma, Non-Hodgkin:

6 (show all 11)
id Gene Variation Type Significance SNP ID Assembly Location
1TP53NM_000546.5(TP53): c.974G> T (p.Gly325Val)single nucleotide variantPathogenicrs121912659GRCh37Chr 17, 7576872: 7576872
2PRF1NM_001083116.1(PRF1): c.1122G> A (p.Trp374Ter)single nucleotide variantPathogenicrs104894176GRCh37Chr 10, 72358355: 72358355
3PRF1NM_001083116.1(PRF1): c.755A> G (p.Asn252Ser)single nucleotide variantPathogenicrs28933375GRCh37Chr 10, 72358722: 72358722
4BRAFNM_004333.4(BRAF): c.1405G> C (p.Gly469Arg)single nucleotide variantPathogenicrs121913357GRCh37Chr 7, 140481403: 140481403
5BRAFNM_004333.4(BRAF): c.1406G> C (p.Gly469Ala)single nucleotide variantPathogenicrs121913355GRCh37Chr 7, 140481402: 140481402
6BRAFNM_004333.4(BRAF): c.1781A> G (p.Asp594Gly)single nucleotide variantPathogenicrs121913338GRCh37Chr 7, 140453154: 140453154
7RAD54BNM_012415.3(RAD54B): c.1778A> G (p.Asn593Ser)single nucleotide variantPathogenicrs114216685GRCh37Chr 8, 95403868: 95403868
8RAD54LNM_001142548.1(RAD54L): c.1331T> A (p.Val444Glu)single nucleotide variantPathogenicrs121908689GRCh37Chr 1, 46738430: 46738430
9CASP10NM_032977.3(CASP10): c.1241C> T (p.Ala414Val)single nucleotide variantPathogenicrs28936699GRCh37Chr 2, 202074111: 202074111
10CASP10NM_032977.3(CASP10): c.769C> T (p.Gln257Ter)single nucleotide variantPathogenicrs121909775GRCh37Chr 2, 202070652: 202070652
11CASP10NM_032977.3(CASP10): c.1042_1043insA (p.Gly348Glufs)insertionPathogenicrs398122800GRCh37Chr 2, 202073912: 202073913

Expression for genes affiliated with Lymphoma, Non-Hodgkin

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Search GEO for disease gene expression data for Lymphoma, Non-Hodgkin.

Pathways for genes affiliated with Lymphoma, Non-Hodgkin

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Pathways related to Lymphoma, Non-Hodgkin according to GeneCards Suite gene sharing:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Homologous recombination36
9.6RAD54L, RAD54B
2
Show member pathways
9.4CASP10, TP53
39.4CASP10, TP53
4
Show member pathways
9.4TP53, CASP10
5
Show member pathways
9.4TP53, CASP10
6
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.4TP53, CASP10
7
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.4TP53, CASP10
8
Show member pathways
9.4CASP10, TP53
99.4CASP10, TP53
10
Show member pathways
9.3PRF1, CASP10
11
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.3PRF1, CASP10
12
Show member pathways
9.1BRAF, CASP10
13
Show member pathways
Signal transduction PTEN pathway58
9.1TP53, BRAF
14
Show member pathways
ErbB receptor signaling network36
ErbB signaling pathway36
9.1TP53, BRAF
159.1TP53, BRAF
16
Show member pathways
9.1BRAF, TP53
179.1TP53, BRAF
18
Show member pathways
9.1BRAF, TP53
19
Show member pathways
9.1BRAF, TP53
20
Show member pathways
9.1BRAF, TP53
219.1BRAF, TP53
229.1BRAF, TP53
239.1BRAF, TP53
24
Show member pathways
9.1TP53, BRAF
25
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
9.1BRAF, TP53
26
Show member pathways
Ras signaling in the CD4+ TCR pathway36
9.0PRF1, BRAF
27
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
8.8TP53, CASP10, PRF1
288.7BRAF, RAD54L, TP53
29
Show member pathways
8.6CASP10, BRAF, TP53
30
Show member pathways
8.6TP53, CASP10, BRAF

Compounds for genes affiliated with Lymphoma, Non-Hodgkin

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Compounds related to Lymphoma, Non-Hodgkin according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1z-vad-fmk43 5910.6CASP10, TP53
2o6-methylguanine439.3TP53, BRAF
3crcs439.2BRAF, TP53
4depsipeptide439.2BRAF, TP53
5geldanamycin43 49 59 1212.1BRAF, TP53
6irinotecan43 49 1210.8BRAF, TP53
7paclitaxel43 49 1210.8CASP10, BRAF, TP53
8cisplatin43 49 59 1211.6TP53, BRAF, CASP10
9serine437.9CASP10, PRF1, BRAF, TP53

GO Terms for genes affiliated with Lymphoma, Non-Hodgkin

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Biological processes related to Lymphoma, Non-Hodgkin according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA strand renaturationGO:00007339.5RAD54L, TP53
2double-strand break repair via homologous recombinationGO:00007249.5RAD54L, RAD54B
3regulation of apoptotic processGO:00429819.4CASP10, TP53
4apoptotic processGO:00069158.5CASP10, PRF1, TP53

Molecular functions related to Lymphoma, Non-Hodgkin according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ubiquitin protein ligase bindingGO:00316259.4CASP10, TP53
2ATP bindingGO:00055248.0RAD54L, RAD54B, BRAF, TP53

Products for genes affiliated with Lymphoma, Non-Hodgkin

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Sources for Lymphoma, Non-Hodgkin

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet