LYG
MCID: LYM051
MIFTS: 49

Lymphomatoid Granulomatosis (LYG) malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Lymphomatoid Granulomatosis

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Wikipedia:65 Lymphomatoid granulomatosis (LYG or LG) is a very rare lymphoproliferative disorder first characterized... more...

MalaCards based summary: Lymphomatoid Granulomatosis, also known as LYG, is related to splenomegaly and myelofibrosis. An important gene associated with Lymphomatoid Granulomatosis is IFNA2 (interferon, alpha 2), and among its related pathways are NOD-like Receptor Signaling Pathways and Interferon Signaling. The drug interferon alfa-2b and the compounds pegasys and entecavir have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and bone.

Aliases & Classifications for Lymphomatoid Granulomatosis

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Sources:
30LifeMap Discovery®, 42NIH Rare Diseases, 44Novoseek, 48Orphanet, 62UMLS, 63UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet
See all sources

Lymphomatoid Granulomatosis, Aliases & Descriptions:

Name: Lymphomatoid Granulomatosis 30 42 44 48 62
 
Lyg 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
lymphomatoid granulomatosis:
Age of onset: Adulthood


External Ids:

UMLS via Orphanet63 C0024307
MESH via Orphanet35 D008230
ICD10 via Orphanet26 C83.8

Related Diseases for Lymphomatoid Granulomatosis

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Graphical network of the top 20 diseases related to Lymphomatoid Granulomatosis:



Diseases related to lymphomatoid granulomatosis

Symptoms for Lymphomatoid Granulomatosis

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Drugs & Therapeutics for Lymphomatoid Granulomatosis

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Drug clinical trials:

Search ClinicalTrials for Lymphomatoid Granulomatosis

Search NIH Clinical Center for Lymphomatoid Granulomatosis

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphomatoid Granulomatosis cell therapies at LifeMap Discovery.

Genetic Tests for Lymphomatoid Granulomatosis

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Anatomical Context for Lymphomatoid Granulomatosis

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MalaCards organs/tissues related to Lymphomatoid Granulomatosis:

32
Lung, Brain, Bone, Skin, T cells, B cells, Bone marrow, Lymph node, Spleen, Spinal cord, Liver, Myeloid, Heart, Salivary gland, Cervix, Temporal lobe

Animal Models for Lymphomatoid Granulomatosis or affiliated genes

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Publications for Lymphomatoid Granulomatosis

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Articles related to Lymphomatoid Granulomatosis:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Cutaneous lesions in a CLIPPERS patient: further confusion between CLIPPERS and grade I lymphomatoid granulomatosis. (24976067)
2014
2
Lymphomatoid Granulomatosis Presenting with Cutaneous Involvement: A Case Report with Review of the Literature. (25355540)
2014
3
Lymphomatoid Granulomatosis-A Single Institute Experience: Pathologic Findings and Clinical Correlations. (25321327)
2014
4
EBV-Negative Cutaneous Lymphomatoid Granulomatosis With Concomitant EBV-Positive Pulmonary Involvement: A Potential Diagnostic and Prognostic Pitfall. (25148107)
2014
5
Fatal pulmonary lymphomatoid granulomatosis in a patient taking methotrexate for rheumatoid arthritis. (23857444)
2014
6
Rituximab in Lymphomatoid Granulomatosis. (23337550)
2013
7
Large granular lymphocyte leukemia and lymphomatoid granulomatosis in the same patient: fortuitous association? (22799270)
2013
8
A rare presentation of a rare disease: pulmonary lymphomatoid granulomatosis. (23227406)
2012
9
Unique presentation of testicular involvement in lymphomatoid granulomatosis. (22722459)
2012
10
Lymphomatoid granulomatosis: CT and FDG-PET findings. (22043148)
2011
11
Laryngeal lymphomatoid granulomatosis in a HIV patient. (21501906)
2011
12
Pulmonary Lymphomatoid Granulomatosis: Report of A Case and Review of Literature. (21968985)
2011
13
Lymphomatoid granulomatosis treated successfully with rituximab in a renal transplant patient. (21559262)
2011
14
A case of lymphomatoid granulomatosis-like lung lesions with abundant infiltrating IgG4-positive plasma cells whose serum IgG4 levels became high following the start of corticosteroid therapy. (20847508)
2010
15
Lymphomatoid granulomatosis. (18283790)
2008
16
Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis. (17200802)
2007
17
Methotrexate-related lymphomatoid granulomatosis: a case report of spontaneous regression of large tumours in multiple organs after cessation of methotrexate therapy in rheumatoid arthritis. (17454938)
2007
18
High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement. (16966281)
2006
19
An 18-year-old man with persistent cough and bilateral lower lung infiltration. Epstein-Barr virus-positive lymphoproliferative disorder consistent with lymphomatoid granulomatosis. (16519586)
2006
20
Arthritis in lymphomatoid granulomatosis: report of a case and review of literature. (14993719)
2004
21
Isolated EBV lymphoproliferative disease in a child with Wiskott-Aldrich syndrome manifesting as cutaneous lymphomatoid granulomatosis and responsive to anti-CD20 immunotherapy. (12835306)
2003
22
A pediatric case of lymphomatoid granulomatosis with onset after completion of chemotherapy for acute myeloid leukemia. (12571471)
2003
23
Lymphomatoid granulomatosis with long survival. (11426249)
2001
24
Radiotherapy to control CNS lymphomatoid granulomatosis: a case report and review of the literature. (10589080)
1999
25
A case of lymphomatoid granulomatosis mimicking sarcoidosis. (10070572)
1998
26
Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: lesions with Epstein-Barr virus infection. (9578085)
1998
27
Cerebral lymphomatoid granulomatosis. (18638900)
1996
28
Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder. (8961876)
1996
29
Lymphomatoid granulomatosis: evidence that some cases represent Epstein-Barr virus-associated B-cell lymphoma. (8910039)
1996
30
Lymphomatoid granulomatosis presenting as a solitary cutaneous lesion. (8169018)
1994
31
Epstein-Barr virus in cutaneous lymphomatoid granulomatosis. (7698731)
1994
32
Radiotherapy: an effective treatment of cerebral involvement by lymphomatoid granulomatosis. (8432184)
1993
33
Diagnosis and treatment of lymphomatoid granulomatosis. (1461861)
1992
34
Lymphomatoid granulomatosis presenting as sudden blindness. (2390249)
1990
35
A case of lymphomatoid granulomatosis with a protracted course and prominent CNS involvement. (2917235)
1989
36
Lymphomatoid granulomatosis of the lung: report of a case. (3441422)
1987
37
Asbestos related interstitial pneumonitis associated with glomerulonephritis and lymphomatoid granulomatosis. (3785987)
1986
38
Lymphomatoid granulomatosis. Light microscopic, electron microscopic and immunohistochemical study. (3862334)
1985
39
Lymphomatoid granulomatosis masquerading as hypernephroma with lung metastases. (6708231)
1984
40
Lymphomatoid granulomatosis with cerebral involvement. (6521847)
1984
41
Lymphomatoid granulomatosis: an analysis of clinical and immunologic characteristics. (6978760)
1982
42
Polymorphic reticulosis (lethal midline granuloma) and lymphomatoid granulomatosis: identical or distinct entities? (7281476)
1981
43
Cutaneous lesions of lymphomatoid granulomatosis. Comparison with lymphomatoid papulosis. (7270809)
1981
44
Lymphomatoid granulomatosis. Report of a patient with severe anemia and clubbing. (7449472)
1980
45
Lymphomatoid granulomatosis. (7357892)
1980
46
Lymphomatoid granulomatosis in a renal transplant recipient. (389224)
1979
47
A lymphomatoid granulomatosis of the lungs in young dogs. (452314)
1979
48
Midline malignant reticulosis and lymphomatoid granulomatosis. A case report. (582659)
1979
49
Use of irradiation in lymphomatoid granulomatosis. (668421)
1978
50
Lymphomatoid granulomatosis after immunosuppression for pemphigus. (686725)
1978

Variations for Lymphomatoid Granulomatosis

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Expression for genes affiliated with Lymphomatoid Granulomatosis

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Expression patterns in normal tissues for genes affiliated with Lymphomatoid Granulomatosis

Search GEO for disease gene expression data for Lymphomatoid Granulomatosis.

Pathways for genes affiliated with Lymphomatoid Granulomatosis

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Pathways related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.3IFNA1, IFNA2
2
Show member pathways
9.3IFNA1, IFNA2
3
Show member pathways
Type III interferon signaling37
9.3IFNA1, IFNA2
4
Show member pathways
9.3IFNA1, IFNA2
59.3IFNA1, IFNA2
6
Show member pathways
Immune response CD16 signaling in NK cells60
9.3IFNA2, IFNA1
79.3IFNA2, IFNA1
8
Show member pathways
9.3IFNA2, IFNA1
99.3IFNA2, IFNA1
109.3IFNA2, IFNA1
11
Show member pathways
9.3IFNA2, IFNA1
129.3IFNA2, IFNA1
139.3IFNA2, IFNA1
14
Show member pathways
9.3IFNA2, IFNA1
159.3IFNA2, IFNA1
16
Show member pathways
9.3IFNA2, IFNA1
179.3IFNA2, IFNA1
189.0CXCL9, IFNA2
19
Show member pathways
8.5CXCL9, IFNA1, IFNA2
20
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.5IFNA2, IFNA1, CXCL9

Compounds for genes affiliated with Lymphomatoid Granulomatosis

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Compounds related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1pegasys449.8IFNA2, IFNA1
2entecavir449.8IFNA2, IFNA1
3famciclovir44 1110.8IFNA1, IFNA2
4n-phosphonacetyl-l-aspartate449.8IFNA1, IFNA2
5intron a449.8IFNA1, IFNA2
6mizoribine449.8IFNA1, IFNA2
7pentostatin44 61 28 1112.8IFNA1, IFNA2
8lomustine44 1110.8IFNA1, IFNA2
9anagrelide44 1110.8IFNA1, IFNA2
105-deoxy-5-fluorouridine449.8IFNA2, IFNA1
11adefovir449.8IFNA1, IFNA2
12amantadine44 1110.7IFNA2, IFNA1
13didanosine44 50 1111.7IFNA2, IFNA1
14acitretin44 1110.7IFNA2, IFNA1
15busulfan44 50 1111.7IFNA1, IFNA2
16levamisole44 1110.7IFNA1, IFNA2
17dacarbazine44 1110.7IFNA2, IFNA1
18acyclovir44 1110.7IFNA1, IFNA2
19temozolomide44 1110.7IFNA2, IFNA1
20imiquimod44 61 28 1112.7IFNA2, IFNA1
21isotretinoin44 1110.7IFNA1, IFNA2
22bcnu449.7IFNA1, IFNA2
23lamivudine44 50 1111.7IFNA2, IFNA1
242,5-oligoadenylate449.7IFNA1, IFNA2
25ursodeoxycholic acid44 24 1111.7IFNA2, IFNA1
26mitoxantrone44 50 1111.7IFNA2, IFNA1
27leucovorin44 50 1111.7IFNA1, IFNA2
28ribavirin44 50 1111.7IFNA2, IFNA1
29melphalan44 50 1111.7IFNA2, IFNA1
30neopterin449.6IFNA2, IFNA1
31rituximab44 50 1111.6IFNA1, IFNA2
32vinblastine44 50 1111.6IFNA2, IFNA1
33bleomycin44 1110.6IFNA2, IFNA1
34thalidomide44 50 61 1112.6IFNA1, IFNA2
35zidovudine44 50 1111.6IFNA2, IFNA1
36polyethylene glycol449.6IFNA2, IFNA1
37hydroxyurea44 50 1111.6IFNA2, IFNA1
38nucleoside449.5IFNA1, IFNA2
39thymidylate449.5IFNA2, IFNA1
40vincristine44 50 1111.5IFNA2, IFNA1
41ccl344 2810.5CXCL9, IFNA1
42cytarabine44 50 1111.4IFNA1, IFNA2
43prednisolone44 28 1111.4IFNA2, IFNA1
445fluorouracil449.2IFNA1, IFNA2
45rantes449.1IFNA1, CXCL9
46retinoid449.0IFNA2, IFNA1
47ifn-alpha449.0IFNA2, IFNA1, CXCL9
48cyclophosphamide44 50 1111.0CXCL9, IFNA1, IFNA2
49vegf448.9IFNA2, IFNA1, CXCL9
50tyrosine448.5IFNA2, IFNA1, CXCL9

GO Terms for genes affiliated with Lymphomatoid Granulomatosis

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Biological processes related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069549.0IFNA2, CXCL9
2defense response to virusGO:0516078.9IFNA2, CXCL9
3cell-cell signalingGO:0072678.7IFNA2, CXCL9

Molecular functions related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0IFNA2, CXCL9

Products for genes affiliated with Lymphomatoid Granulomatosis

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Sources for Lymphomatoid Granulomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet