LYG
MCID: LYM051
MIFTS: 43

Lymphomatoid Granulomatosis (LYG) malady

Blood, Cancer, Immune categories

Summaries for Lymphomatoid Granulomatosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Lymphomatoid granulomatosis is a neoplastic disease. more...

MalaCards: Lymphomatoid Granulomatosis, also known as LYG, is related to acquired immunodeficiency syndrome and splenomegaly. An important gene associated with Lymphomatoid Granulomatosis is IFNA2 (interferon, alpha 2), and among its related pathways are Immune response IFN alpha/beta signaling pathway and Jak-STAT signaling pathway. The drug interferon alfa-2b and the compounds pegasys and entecavir have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord.

Aliases & Classifications for Lymphomatoid Granulomatosis

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 31LifeMap Discovery™, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood, Immune


Characteristics (Orphanet epidemiological data):

49
lymphomatoid granulomatosis:
Age of onset: Adulthood


Aliases & Descriptions:

lymphomatoid granulomatosis 43 45 49 31 61
lyg 49


External Ids:

MESH via Orphanet36 D008230
ICD10 via Orphanet26 C83.8
SNOMED-CT via Orphanet58 239940004
UMLS via Orphanet62 C0024307

Related Diseases for Lymphomatoid Granulomatosis

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lymphomatoid Granulomatosis:



Diseases related to lymphomatoid granulomatosis

Clinical Features for Lymphomatoid Granulomatosis

Drugs & Therapeutics for Lymphomatoid Granulomatosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphomatoid Granulomatosis

Drug clinical trials:

Search ClinicalTrials for Lymphomatoid Granulomatosis

Search NIH Clinical Center for Lymphomatoid Granulomatosis

Search CenterWatch for Lymphomatoid Granulomatosis

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphomatoid Granulomatosis cell therapies at LifeMap Discovery.

Genetic Tests for Lymphomatoid Granulomatosis

Anatomical Context for Lymphomatoid Granulomatosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Lymphomatoid Granulomatosis:

33
Skin, Liver, Spinal cord, Brain, Lymph node, Lung, Spleen, Bone marrow, Heart, Small intestine, Salivary gland, Cervix, Myeloid, T cells, B lymphoblasts, B cells, Temporal lobe

Animal Models for Lymphomatoid Granulomatosis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Lymphomatoid Granulomatosis

Sources:
51PubMed
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Articles related to Lymphomatoid Granulomatosis:

(show top 50)    (show all 355)
idTitleAuthorsYear
1
Rituximab in Lymphomatoid Granulomatosis. (23337550)
2013
2
Methotrexate-induced lymphoproliferative disease: Epstein-Barr virus-associated lymphomatoid granulomatosis. (23733760)
2013
3
Hematopoietic stem cell transplantation in patients with lymphomatoid granulomatosis: a European group for blood and marrow transplantation report. (23948061)
2013
4
Long-term remission after multiple relapses in an elderly patient with lymphomatoid granulomatosis after rituximab and high-dose cytarabine chemotherapy without stem-cell transplantation. (23796993)
2013
5
Reversible iatrogenic, MTX-associated EBV-driven lymphoproliferation with histopathological features of a lymphomatoid granulomatosis in a patient with rheumatoid arthritis. (23529185)
2013
6
Pulmonary angiocentric lymphoma (lymphomatoid granulomatosis) in a donkey. (21571299)
2012
7
Epicardial mass causing cardiac compression: an unusual involvement in lymphomatoid granulomatosis. (22412244)
2012
8
Laryngeal lymphomatoid granulomatosis in a HIV patient. (21501906)
2011
9
Tumoral presentation of primary central nervous system lymphomatoid granulomatosis. (21792698)
2011
10
Teaching NeuroImages: lymphomatoid granulomatosis involving lung and brain in an immunocompetent woman. (21947537)
2011
11
Pulmonary lymphomatoid granulomatosis in a renal allograft recipient. (17511820)
2008
12
Pulmonary lymphomatoid granulomatosis in a dog: evidence of immunophenotypic diversity and relationship to human pulmonary lymphomatoid granulomatosis and pulmonary Hodgkin's disease. (18039906)
2007
13
Reversed halo sign in lymphomatoid granulomatosis. (17762047)
2007
14
Successful treatment of mediastinal lymphomatoid granulomatosis with rituximab monotherapy. (15693798)
2005
15
Lymphomatoid granulomatosis in a pediatric patient. (15158227)
2004
16
A pediatric case of lymphomatoid granulomatosis with onset after completion of chemotherapy for acute myeloid leukemia. (12571471)
2003
17
Posttransplant diffuse large B-cell lymphoma of "lymphomatoid granulomatosis" type. (12587601)
2002
18
Pulmonary lymphomatoid granulomatosis in a cat. (11021438)
2000
19
Lymphomatoid granulomatosis: radiologic features and pathologic correlations. (11044036)
2000
20
Radiotherapy to control CNS lymphomatoid granulomatosis: a case report and review of the literature. (10589080)
1999
21
Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: lesions with Epstein-Barr virus infection. (9578085)
1998
22
Lymphomatoid granulomatosis presenting as an isolated unilateral optic neuropathy. A clinicopathologic report. (9621274)
1998
23
Successful treatment of lymphomatoid granulomatosis using cyclosporin-A after failure of intensive chemotherapy. (8895691)
1996
24
Lymphomatoid granulomatosis, an unusual cause of inflammatory arthritis. (8035414)
1994
25
Diagnosis and treatment of lymphomatoid granulomatosis. (1461861)
1992
26
Central nervous system angiocentric, angiodestructive T-cell lymphoma (lymphomatoid granulomatosis). (1546376)
1992
27
Choroidal involvement in lymphomatoid granulomatosis. (1751466)
1991
28
Eight cases of canine lymphomatoid granulomatosis. (1858255)
1991
29
Lymphomatoid granulomatosis. (2108775)
1990
30
Endocrine dysfunction in lymphomatoid granulomatosis. (2764822)
1989
31
CT of CNS lesions in lymphomatoid granulomatosis: case report. (3132835)
1988
32
Lymphomatoid granulomatosis: a case report. (3230299)
1988
33
Necrobiosis-lipoidica-like skin manifestation in lymphomatoid granulomatosis (Liebow). (3556699)
1987
34
Lymphomatoid granulomatosis and the acquired immunodeficiency syndrome (AIDS) (3688694)
1987
35
Asbestos related interstitial pneumonitis associated with glomerulonephritis and lymphomatoid granulomatosis. (3785987)
1986
36
Bone marrow transplantation in lymphomatoid granulomatosis. Report of a case. (3521844)
1986
37
Cutaneous lesions of lymphomatoid granulomatosis. (3954395)
1986
38
Lymphomatoid granulomatosis masquerading as hypernephroma with lung metastases. (6708231)
1984
39
Lymphomatoid granulomatosis with cerebral involvement. (6521847)
1984
40
Lymphomatoid granulomatosis. (6405966)
1983
41
Lymphomatoid granulomatosis involving the gastrointestinal tract. Two case reports and a review of the literature. (6600693)
1983
42
Gastrointestinal involvement in lymphomatoid granulomatosis. Report of a case review of the literature. (6600414)
1983
43
Lymphomatoid granulomatosis and Epstein-Barr virus. (6288216)
1982
44
Lymphomatoid granulomatosis: a T-cell disorder? (6174046)
1982
45
Lymphomatoid granulomatosis. (7070449)
1982
46
Polymorphic reticulosis, lymphomatoid granulomatosis. Two diseases or one? (713593)
1978
47
Lymphomatoid granulomatosis: association with retroperitoneal fibrosis and evidence of impaired cell-mediated immunity. (262098)
1977
48
Lymphomatoid granulomatosis presenting as fever of unknown origin. (576991)
1977
49
Lymphomatoid granulomatosis: report of a case. (948712)
1976
50
Editorial: Lymphomatoid granulomatosis. (4821520)
1974

Genetic Variations for Lymphomatoid Granulomatosis

Expression for genes affiliated with Lymphomatoid Granulomatosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphomatoid Granulomatosis

Search GEO for disease gene expression data for Lymphomatoid Granulomatosis.

Pathways for genes affiliated with Lymphomatoid Granulomatosis

Sources:
54Reactome, 12EMD Millipore, 30KEGG, 52QIAGEN, 53R&D Systems, 38NCBI BioSystems Database
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Pathways related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
Hide members
9.3IFNA1, IFNA2
29.3IFNA1, IFNA2
39.3IFNA1, IFNA2
49.3IFNA1, IFNA2
59.3IFNA1, IFNA2
6
Hide members
9.3IFNA1, IFNA2
7
Hide members
9.3IFNA1, IFNA2
89.3IFNA1, IFNA2
9
Hide members
9.3IFNA1, IFNA2
109.3IFNA1, IFNA2
119.3IFNA1, IFNA2
129.3IFNA2, IFNA1
139.3IFNA2, IFNA1
14
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.3IFNA2, IFNA1
159.0CXCL9, IFNA2
16
Hide members
8.5CXCL9, IFNA1, IFNA2
17
Hide members
8.5IFNA2, IFNA1, CXCL9

Compounds for genes affiliated with Lymphomatoid Granulomatosis

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 50PharmGKB
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Compounds related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1pegasys459.8IFNA1, IFNA2
2entecavir459.8IFNA2, IFNA1
3n-phosphonacetyl-l-aspartate459.8IFNA2, IFNA1
4intron a459.8IFNA1, IFNA2
5famciclovir45 1110.8IFNA1, IFNA2
6mizoribine459.8IFNA1, IFNA2
7lomustine45 1110.8IFNA1, IFNA2
8pentostatin45 60 29 1112.7IFNA1, IFNA2
9anagrelide45 1110.7IFNA2, IFNA1
105-deoxy-5-fluorouridine459.7IFNA2, IFNA1
11adefovir459.7IFNA2, IFNA1
12amantadine45 1110.7IFNA2, IFNA1
13didanosine45 1110.7IFNA1, IFNA2
14acitretin45 1110.7IFNA2, IFNA1
15busulfan45 1110.7IFNA2, IFNA1
16levamisole45 1110.7IFNA1, IFNA2
17dacarbazine45 1110.7IFNA1, IFNA2
18acyclovir45 1110.7IFNA1, IFNA2
19temozolomide45 1110.7IFNA2, IFNA1
20imiquimod45 29 60 1112.7IFNA2, IFNA1
21isotretinoin45 1110.7IFNA2, IFNA1
22bcnu459.7IFNA1, IFNA2
232,5-oligoadenylate459.7IFNA2, IFNA1
24ursodeoxycholic acid45 11 2411.7IFNA1, IFNA2
25leucovorin45 50 1111.7IFNA2, IFNA1
26mitoxantrone45 50 1111.7IFNA2, IFNA1
27ribavirin45 50 1111.7IFNA2, IFNA1
28melphalan45 1110.6IFNA2, IFNA1
29neopterin459.6IFNA1, IFNA2
30rituximab45 50 1111.6IFNA1, IFNA2
31vinblastine45 50 1111.6IFNA2, IFNA1
32bleomycin45 1110.6IFNA2, IFNA1
33thalidomide45 50 60 1112.6IFNA2, IFNA1
34zidovudine45 1110.5IFNA1, IFNA2
35polyethylene glycol459.5IFNA1, IFNA2
36hydroxyurea45 50 1111.5IFNA2, IFNA1
37cytarabine45 50 1111.4IFNA1, IFNA2
38ccl345 2910.4IFNA1, CXCL9
39nucleoside459.4IFNA2, IFNA1
40vincristine45 50 1111.3IFNA1, IFNA2
415fluorouracil459.3IFNA2, IFNA1
42thymidylate459.2IFNA2, IFNA1
43prednisolone45 29 1111.0IFNA2, IFNA1
44ifn-alpha459.0IFNA1, CXCL9, IFNA2
45cyclophosphamide45 50 1110.9IFNA1, IFNA2, CXCL9
46vegf458.8IFNA1, IFNA2, CXCL9

GO Terms for genes affiliated with Lymphomatoid Granulomatosis

Sources:
16Gene Ontology
See all sources

Biological processes related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.0CXCL9, IFNA2

Molecular functions related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0CXCL9, IFNA2

Products for genes affiliated with Lymphomatoid Granulomatosis

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  • Lysates
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Sources for Lymphomatoid Granulomatosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet