LYG
MCID: LYM051
MIFTS: 34

Lymphomatoid Granulomatosis (LYG) malady

Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Lymphomatoid Granulomatosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphomatoid granulomatosis (LYG or LG) is a very rare lymphoproliferative disorder first characterized... more...

MalaCards: Lymphomatoid Granulomatosis, also known as LYG, is related to acquired immunodeficiency syndrome and rheumatoid arthritis. An important gene associated with Lymphomatoid Granulomatosis is IFNA2 (interferon, alpha 2), and among its related pathways are Immune response IFN alpha/beta signaling pathway and Jak-STAT signaling pathway. The drug interferon alfa-2b and the compounds pegasys and entecavir have been mentioned in the context of this disorder. Affiliated tissues include bone.

Aliases & Classifications for Lymphomatoid Granulomatosis

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 30LifeMap Discovery™, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
lymphomatoid granulomatosis:
Age of onset: Adulthood


Aliases & Descriptions:

lymphomatoid granulomatosis 42 44 48 30 60
lyg 48


External Ids:

MESH via Orphanet35 D008230
ICD10 via Orphanet26 C83.8
SNOMED-CT via Orphanet57 239940004
UMLS via Orphanet61 C0024307

Related Diseases for Lymphomatoid Granulomatosis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Lymphomatoid Granulomatosis:



Diseases related to lymphomatoid granulomatosis

Clinical Features for Lymphomatoid Granulomatosis

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Drugs & Therapeutics for Lymphomatoid Granulomatosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lymphomatoid Granulomatosis

Drug clinical trials:

Search ClinicalTrials for Lymphomatoid Granulomatosis

Search NIH Clinical Center for Lymphomatoid Granulomatosis

Search CenterWatch for Lymphomatoid Granulomatosis

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphomatoid Granulomatosis cell therapies at LifeMap Discovery.

Genetic Tests for Lymphomatoid Granulomatosis

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Anatomical Context for Lymphomatoid Granulomatosis

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32MalaCards
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MalaCards organs/tissues related to Lymphomatoid Granulomatosis:

32
Bone

Animal Models for Lymphomatoid Granulomatosis or affiliated genes

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Publications for Lymphomatoid Granulomatosis

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Genetic Variations for Lymphomatoid Granulomatosis

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Expression for genes affiliated with Lymphomatoid Granulomatosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphomatoid Granulomatosis

Search GEO for disease gene expression data for Lymphomatoid Granulomatosis.

Pathways for genes affiliated with Lymphomatoid Granulomatosis

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Sources:
53Reactome, 12EMD Millipore, 29KEGG, 51QIAGEN, 52R&D Systems, 37NCBI BioSystems Database
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Pathways related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Immune response IFN alpha/beta signaling pathway
Hide members
9.3IFNA1, IFNA2
29.3IFNA1, IFNA2
39.3IFNA1, IFNA2
49.3IFNA1, IFNA2
59.3IFNA1, IFNA2
6
Hide members
9.3IFNA1, IFNA2
7
Hide members
9.3IFNA1, IFNA2
89.3IFNA1, IFNA2
9
Hide members
9.3IFNA1, IFNA2
109.3IFNA1, IFNA2
119.3IFNA1, IFNA2
129.3IFNA2, IFNA1
139.3IFNA2, IFNA1
14
Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway
9.3IFNA2, IFNA1
159.0CXCL9, IFNA2
16
Hide members
8.5CXCL9, IFNA1, IFNA2
17
Hide members
8.5IFNA2, IFNA1, CXCL9

Compounds for genes affiliated with Lymphomatoid Granulomatosis

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1pegasys449.8IFNA1, IFNA2
2entecavir449.8IFNA2, IFNA1
3n-phosphonacetyl-l-aspartate449.8IFNA2, IFNA1
4intron a449.8IFNA1, IFNA2
5famciclovir44 1110.8IFNA1, IFNA2
6mizoribine449.8IFNA1, IFNA2
7lomustine44 1110.8IFNA1, IFNA2
8pentostatin44 59 28 1112.7IFNA1, IFNA2
9anagrelide44 1110.7IFNA2, IFNA1
105-deoxy-5-fluorouridine449.7IFNA2, IFNA1
11adefovir449.7IFNA2, IFNA1
12amantadine44 1110.7IFNA2, IFNA1
13didanosine44 1110.7IFNA1, IFNA2
14acitretin44 1110.7IFNA2, IFNA1
15busulfan44 1110.7IFNA2, IFNA1
16levamisole44 1110.7IFNA1, IFNA2
17dacarbazine44 1110.7IFNA1, IFNA2
18acyclovir44 1110.7IFNA1, IFNA2
19temozolomide44 1110.7IFNA2, IFNA1
20imiquimod44 28 59 1112.7IFNA2, IFNA1
21isotretinoin44 1110.7IFNA2, IFNA1
22bcnu449.7IFNA1, IFNA2
232,5-oligoadenylate449.7IFNA2, IFNA1
24ursodeoxycholic acid44 11 2411.7IFNA1, IFNA2
25leucovorin44 49 1111.7IFNA2, IFNA1
26mitoxantrone44 49 1111.7IFNA2, IFNA1
27ribavirin44 49 1111.7IFNA2, IFNA1
28melphalan44 1110.6IFNA2, IFNA1
29neopterin449.6IFNA1, IFNA2
30rituximab44 49 1111.6IFNA1, IFNA2
31vinblastine44 49 1111.6IFNA2, IFNA1
32bleomycin44 1110.6IFNA2, IFNA1
33thalidomide44 49 59 1112.6IFNA2, IFNA1
34zidovudine44 1110.5IFNA1, IFNA2
35polyethylene glycol449.5IFNA1, IFNA2
36hydroxyurea44 49 1111.5IFNA2, IFNA1
37cytarabine44 49 1111.4IFNA1, IFNA2
38ccl344 2810.4IFNA1, CXCL9
39nucleoside449.4IFNA2, IFNA1
40vincristine44 49 1111.3IFNA1, IFNA2
415fluorouracil449.3IFNA2, IFNA1
42thymidylate449.2IFNA2, IFNA1
43prednisolone44 28 1111.0IFNA2, IFNA1
44ifn-alpha449.0IFNA1, CXCL9, IFNA2
45cyclophosphamide44 49 1110.9IFNA1, IFNA2, CXCL9
46vegf448.8IFNA1, IFNA2, CXCL9

GO Terms for genes affiliated with Lymphomatoid Granulomatosis

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Sources:
16Gene Ontology
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Biological processes related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1defense response to virusGO:0516079.0CXCL9, IFNA2

Molecular functions related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:0051259.0CXCL9, IFNA2

Products for genes affiliated with Lymphomatoid Granulomatosis

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Lymphomatoid Granulomatosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet