Lymphomatoid Granulomatosis malady

Wikipedia: Lymphomatoid granulomatosis is a neoplastic disease.⁴⁴ more...

MalaCards: Lymphomatoid Granulomatosis is related to radiculopathy and inclusion body myositis. An important gene associated with Lymphomatoid Granulomatosis is CXCL9 (chemokine (C-X-C motif) ligand 9), and among its related pathways are Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway and Immune response IFN alpha/beta signaling pathway. The drug interferon alfa-2b and the compounds ccl3 and pegasys have been mentioned in the context of this disorder.

lymphomatoid granulomatosis 30 32 43

Diseases related to lymphomatoid granulomatosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 109)

id	Related Disease	Score	Top Affiliating Genes
1	radiculopathy	12.8	CXCL9, IFNA1
2	inclusion body myositis	12.8	IFNA1, CXCL9
3	cork-handlers' disease	12.8	CXCL9, IFNA1
4	pulmonary sarcoidosis	12.8	IFNA1, CXCL9
5	cerebral malaria	12.7	CXCL9, IFNA1
6	burkitt's lymphoma	12.7	IFNA1, CXCL9
7	granulomatous hepatitis	12.7	IFNA2, IFNA1
8	panuveitis	12.7	IFNA2, IFNA1
9	hepatitis d	12.7	IFNA2, IFNA1
10	papilloma	12.7	IFNA2, IFNA1
11	classic kaposi sarcoma	12.7	IFNA1, IFNA2
12	polyarteritis nodosa	12.7	IFNA2, IFNA1
13	autoimmune thrombocytopenic purpura	12.7	IFNA2, IFNA1
14	hypothyroidism	12.6	IFNA1, IFNA2
15	sezary's disease	12.6	IFNA1, IFNA2
16	21-hydroxylase deficiency	12.6	IFNA1, IFNA2
17	membranoproliferative glomerulonephritis type 2	12.6	IFNA2, IFNA1
18	portal vein thrombosis	12.6	IFNA2, IFNA1
19	herpes zoster	12.6	IFNA1, IFNA2
20	hypereosinophilic syndrome	12.6	IFNA2, IFNA1
21	sm-ahnmd	12.6	IFNA2, IFNA1
22	factor vii deficiency	12.6	IFNA1, IFNA2
23	behcet's disease	12.6	IFNA2, IFNA1
24	cutaneous lupus erythematosus	12.6	IFNA2, IFNA1
25	hepatitis b	12.6	IFNA2, IFNA1
26	splenomegaly	12.6	IFNA1, IFNA2
27	subacute sclerosing panencephalitis	12.6	IFNA1, IFNA2
28	cutaneous t cell lymphoma	12.6	IFNA1, IFNA2
29	autoimmune hemolytic anemia	12.6	IFNA2, IFNA1
30	hepatitis e	12.6	IFNA2, IFNA1
31	factor v leiden thrombophilia	12.6	IFNA2, IFNA1
32	kaposi's sarcoma	12.6	IFNA1, IFNA2
33	cryoglobulinemia	12.6	IFNA2, IFNA1
34	west nile virus	12.6	IFNA2, IFNA1
35	hepatitis	12.6	IFNA1, IFNA2
36	thrombocytosis	12.6	IFNA1, IFNA2
37	mastocytosis	12.6	IFNA2, IFNA1
38	hairy cell leukemia	12.6	IFNA1, IFNA2
39	hemophilia	12.6	IFNA2, IFNA1
40	essential thrombocythemia	12.6	IFNA2, IFNA1
41	angiosarcoma	12.6	IFNA2, IFNA1
42	disseminated intravascular coagulation	12.6	IFNA1, IFNA2
43	hepatic fibrosis renal cysts mental retardation	12.6	IFNA2, IFNA1
44	biliary tract cancer	12.6	IFNA1, IFNA2
45	juvenile rheumatoid arthritis	12.6	IFNA2, IFNA1
46	hypersensitivity reaction type ii disease	12.6	IFNA1, CXCL9
47	hepatitis a	12.6	IFNA1, IFNA2
48	leukopenia	12.6	IFNA1, IFNA2
49	polycythemia vera	12.5	IFNA1, IFNA2
50	myelofibrosis	12.5	IFNA1, IFNA2

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 interferon alfa-2b

Articles related to lymphomatoid granulomatosis:

id	Title	Authors	Year	Affiliating Genes
1	Lymphomatoid granulomatosis--remission induction with interferon-alpha 2b (9340250)	Richter C.... Gross W.L.	1997	IFNA2, IFNA1
2	Lymphomatoid granulomatosis: pathogenesis, pathology and clinical implications. (9547995)	Jaffe E.S.... Wilson W.H.	1997	IFNA2
3	Association of lymphomatoid granulomatosis with Epstein-Barr viral infection of B lymphocytes and response to interferon-alpha 2b. (8639820)	Wilson W.H.... Jaffe E.S.	1996	IFNA2

Genes related to lymphomatoid granulomatosis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CXCL9	chemokine (C-X-C motif) ligand 9	11.0
2	IFNA2	interferon, alpha 2	11.0	Publications
3	IFNA1	interferon, alpha 1	11.0	Publications

Pathways related to lymphomatoid granulomatosis according to GeneDecks:

(show all 18)

id	Pathway	Score	Top Affiliating Genes
1	Immune response_TLR3 and TLR4 induce TICAM1-specific signaling pathway41	9.4	IFNA1, IFNA2
2	Immune response IFN alpha/beta signaling pathway10	9.4	IFNA1, IFNA2
3	Immune response_IFN alpha/beta signaling pathway41	9.4	IFNA1, IFNA2
4	Cytokine Network36	9.4	IFNA1, IFNA2
5	Regulation of autophagy20	9.4	IFNA1, IFNA2
6	all-trans-Retinoic Acid Mediated Apoptosis36	9.4	IFNA2, IFNA1
7	Autoimmune thyroid disease20	9.4	IFNA2, IFNA1
8	Cytosolic DNA-sensing pathway20	9.3	IFNA1, IFNA2
9	RIG-I-like receptor signaling pathway20	9.3	IFNA2, IFNA1
10	Interferon Pathway36	9.3	IFNA2, IFNA1
11	Innate Immune System38	9.2	IFNA1, IFNA2
12	Measles20	9.2	IFNA2, IFNA1
13	Hepatitis C20	9.1	IFNA1, IFNA2
14	Influenza A20	9.1	IFNA2, IFNA1
15	Natural killer cell mediated cytotoxicity20	9.0	IFNA1, IFNA2
16	Jak-STAT signaling pathway20	8.8	IFNA2, IFNA1
17	Toll-like receptor signaling pathway20	8.8	IFNA1, IFNA2, CXCL9
18	Cytokine-cytokine receptor interaction20	8.8	IFNA1, IFNA2, CXCL9

Compounds related to lymphomatoid granulomatosis according to GeneDecks:

(show all 45)

id	Compound	Score	Top Affiliating Genes
1	ccl332	9.6	CXCL9, IFNA1
2	pegasys32	9.6	IFNA1, IFNA2
3	entecavir32	9.6	IFNA1, IFNA2
4	intron a32	9.6	IFNA2, IFNA1
5	famciclovir32 9 9	11.6	IFNA2, IFNA1
6	mizoribine32	9.6	IFNA1, IFNA2
7	n-phosphonacetyl-l-aspartate32	9.6	IFNA2, IFNA1
8	pentostatin32 42 9 9	12.5	IFNA1, IFNA2
9	anagrelide32 9 9	11.5	IFNA1, IFNA2
10	lomustine32 9 9	11.5	IFNA1, IFNA2
11	5-deoxy-5-fluorouridine32	9.5	IFNA2, IFNA1
12	adefovir32	9.5	IFNA2, IFNA1
13	amantadine32 9 9	11.5	IFNA1, IFNA2
14	didanosine32 9 9	11.5	IFNA1, IFNA2
15	acyclovir32	9.5	IFNA1, IFNA2
16	busulfan32 9 9	11.5	IFNA1, IFNA2
17	acitretin32 9 9	11.5	IFNA2, IFNA1
18	levamisole32 9 9	11.5	IFNA1, IFNA2
19	dacarbazine32 9 9	11.5	IFNA1, IFNA2
20	imiquimod32 42 9 9	12.5	IFNA2, IFNA1
21	lamivudine32 9 9	11.5	IFNA2, IFNA1
22	temozolomide32 9 9	11.5	IFNA1, IFNA2
23	bcnu32	9.5	IFNA1, IFNA2
24	isotretinoin32 9 9	11.5	IFNA2, IFNA1
25	2,5-oligoadenylate32	9.5	IFNA2, IFNA1
26	ursodeoxycholic acid32 9 18 9	12.5	IFNA1, IFNA2
27	leucovorin32 34 9 9	12.5	IFNA1, IFNA2
28	mitoxantrone32 9 9	11.4	IFNA2, IFNA1
29	ribavirin32 34 9 9	12.4	IFNA2, IFNA1
30	thalidomide32 42 9 9	12.4	IFNA1, IFNA2
31	melphalan32 9 9	11.4	IFNA2, IFNA1
32	neopterin32	9.4	IFNA2, IFNA1
33	rituximab32 34 9 9	12.4	IFNA1, IFNA2
34	vinblastine32 9 9	11.4	IFNA2, IFNA1
35	zidovudine32 9 9	11.3	IFNA2, IFNA1
36	bleomycin32 9 9	11.3	IFNA2, IFNA1
37	polyethylene glycol32	9.3	IFNA2, IFNA1
38	hydroxyurea32 9 9	11.2	IFNA1, IFNA2
39	cytarabine32 34 9 9	12.2	IFNA1, IFNA2
40	nucleoside32	9.1	IFNA1, IFNA2
41	prednisolone32 9 9	11.1	IFNA2, IFNA1
42	vincristine32 34 9 9	12.0	IFNA2, IFNA1
43	ifn-alpha32	8.9	IFNA1, CXCL9, IFNA2
44	cyclophosphamide32 34 9 9	11.9	IFNA2, IFNA1, CXCL9
45	thymidylate32	8.8	IFNA1, IFNA2

Molecular functions related to lymphomatoid granulomatosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:005125	9.0	IFNA2, CXCL9