MCID: LYM051
MIFTS: 49

Lymphomatoid Granulomatosis malady

Rare diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Lymphomatoid Granulomatosis

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Wikipedia:65 Lymphomatoid granulomatosis (LYG or LG) is a very rare lymphoproliferative disorder first characterized... more...

MalaCards based summary: Lymphomatoid Granulomatosis, also known as lyg, is related to burkitt lymphoma and splenomegaly. An important gene associated with Lymphomatoid Granulomatosis is IFNA2 (interferon, alpha 2), and among its related pathways are NOD-like Receptor Signaling Pathways and Interferon Signaling. The drug interferon alfa-2b and the compounds pegasys and entecavir have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and t cells.

Aliases & Classifications for Lymphomatoid Granulomatosis

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Sources:
32LifeMap Discovery®, 43NIH Rare Diseases, 45Novoseek, 49Orphanet, 62UMLS, 63UMLS via Orphanet, 36MESH via Orphanet, 28ICD10 via Orphanet
See all sources

Lymphomatoid Granulomatosis, Aliases & Descriptions:

Name: Lymphomatoid Granulomatosis 32 43 45 49 62
 
Lyg 49


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
lymphomatoid granulomatosis:
Age of onset: Adult


External Ids:

Orphanet49 86869
UMLS via Orphanet63 C0024307
MESH via Orphanet36 D008230
ICD10 via Orphanet28 C83.8

Related Diseases for Lymphomatoid Granulomatosis

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Graphical network of the top 20 diseases related to Lymphomatoid Granulomatosis:



Diseases related to lymphomatoid granulomatosis

Symptoms for Lymphomatoid Granulomatosis

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Drugs & Therapeutics for Lymphomatoid Granulomatosis

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Drug clinical trials:

Search ClinicalTrials for Lymphomatoid Granulomatosis

Search NIH Clinical Center for Lymphomatoid Granulomatosis

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Lymphomatoid Granulomatosis cell therapies at LifeMap Discovery.

Genetic Tests for Lymphomatoid Granulomatosis

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Anatomical Context for Lymphomatoid Granulomatosis

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MalaCards organs/tissues related to Lymphomatoid Granulomatosis:

33
Lung, Brain, T cells, Bone, Skin, B cells, Bone marrow, Lymph node, Spleen, Spinal cord, Liver, Myeloid, Heart, Salivary gland, Cervix, Temporal lobe

Animal Models for Lymphomatoid Granulomatosis or affiliated genes

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Publications for Lymphomatoid Granulomatosis

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Articles related to Lymphomatoid Granulomatosis:

(show top 50)    (show all 377)
idTitleAuthorsYear
1
Cutaneous lesions in a CLIPPERS patient: further confusion between CLIPPERS and grade I lymphomatoid granulomatosis. (24976067)
2014
2
Lymphomatoid Granulomatosis Presenting with Cutaneous Involvement: A Case Report with Review of the Literature. (25355540)
2014
3
An eschar and violaceous nodules as the presenting signs of lymphomatoid granulomatosis. (25419752)
2014
4
Lymphomatoid Granulomatosis-A Single Institute Experience: Pathologic Findings and Clinical Correlations. (25321327)
2014
5
Rituximab for pulmonary lymphomatoid granulomatosis which developed as a complication of methotrexate and azathioprine therapy for rheumatoid arthritis. (25674479)
2014
6
Rituximab in Lymphomatoid Granulomatosis. (23337550)
2013
7
Large granular lymphocyte leukemia and lymphomatoid granulomatosis in the same patient: fortuitous association? (22799270)
2013
8
A rare presentation of a rare disease: pulmonary lymphomatoid granulomatosis. (23227406)
2012
9
Unique presentation of testicular involvement in lymphomatoid granulomatosis. (22722459)
2012
10
Lymphomatoid granulomatosis: CT and FDG-PET findings. (22043148)
2011
11
Laryngeal lymphomatoid granulomatosis in a HIV patient. (21501906)
2011
12
Pulmonary Lymphomatoid Granulomatosis: Report of A Case and Review of Literature. (21968985)
2011
13
Lymphomatoid granulomatosis treated successfully with rituximab in a renal transplant patient. (21559262)
2011
14
A case of lymphomatoid granulomatosis-like lung lesions with abundant infiltrating IgG4-positive plasma cells whose serum IgG4 levels became high following the start of corticosteroid therapy. (20847508)
2010
15
Lymphomatoid granulomatosis. (18283790)
2008
16
Lymphomatoid granulomatosis and diffuse alveolar damage associated with methotrexate therapy in a patient with rheumatoid arthritis. (17200802)
2007
17
Methotrexate-related lymphomatoid granulomatosis: a case report of spontaneous regression of large tumours in multiple organs after cessation of methotrexate therapy in rheumatoid arthritis. (17454938)
2007
18
High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement. (16966281)
2006
19
Arthritis in lymphomatoid granulomatosis: report of a case and review of literature. (14993719)
2004
20
Isolated EBV lymphoproliferative disease in a child with Wiskott-Aldrich syndrome manifesting as cutaneous lymphomatoid granulomatosis and responsive to anti-CD20 immunotherapy. (12835306)
2003
21
A pediatric case of lymphomatoid granulomatosis with onset after completion of chemotherapy for acute myeloid leukemia. (12571471)
2003
22
Lymphomatoid granulomatosis with long survival. (11426249)
2001
23
Radiotherapy to control CNS lymphomatoid granulomatosis: a case report and review of the literature. (10589080)
1999
24
Lymphomatoid granulomatosis following autologous stem cell transplantation. (10037054)
1999
25
A case of lymphomatoid granulomatosis mimicking sarcoidosis. (10070572)
1998
26
Pulmonary lymphomatoid granulomatosis in acquired immunodeficiency syndrome: lesions with Epstein-Barr virus infection. (9578085)
1998
27
Cerebral lymphomatoid granulomatosis. (18638900)
1996
28
Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder. (8961876)
1996
29
Lymphomatoid granulomatosis: evidence that some cases represent Epstein-Barr virus-associated B-cell lymphoma. (8910039)
1996
30
Lymphomatoid granulomatosis presenting as a solitary cutaneous lesion. (8169018)
1994
31
Epstein-Barr virus in cutaneous lymphomatoid granulomatosis. (7698731)
1994
32
Radiotherapy: an effective treatment of cerebral involvement by lymphomatoid granulomatosis. (8432184)
1993
33
Diagnosis and treatment of lymphomatoid granulomatosis. (1461861)
1992
34
Lymphomatoid granulomatosis presenting as sudden blindness. (2390249)
1990
35
A case of lymphomatoid granulomatosis with a protracted course and prominent CNS involvement. (2917235)
1989
36
Lymphomatoid granulomatosis of the lung: report of a case. (3441422)
1987
37
Asbestos related interstitial pneumonitis associated with glomerulonephritis and lymphomatoid granulomatosis. (3785987)
1986
38
Lymphomatoid granulomatosis. Light microscopic, electron microscopic and immunohistochemical study. (3862334)
1985
39
Lymphomatoid granulomatosis masquerading as hypernephroma with lung metastases. (6708231)
1984
40
Lymphomatoid granulomatosis with cerebral involvement. (6521847)
1984
41
Lymphomatoid granulomatosis: an analysis of clinical and immunologic characteristics. (6978760)
1982
42
Polymorphic reticulosis (lethal midline granuloma) and lymphomatoid granulomatosis: identical or distinct entities? (7281476)
1981
43
Cutaneous lesions of lymphomatoid granulomatosis. Comparison with lymphomatoid papulosis. (7270809)
1981
44
Lymphomatoid granulomatosis. Report of a patient with severe anemia and clubbing. (7449472)
1980
45
Lymphomatoid granulomatosis. (7357892)
1980
46
Lymphomatoid granulomatosis in a renal transplant recipient. (389224)
1979
47
A lymphomatoid granulomatosis of the lungs in young dogs. (452314)
1979
48
Midline malignant reticulosis and lymphomatoid granulomatosis. A case report. (582659)
1979
49
Use of irradiation in lymphomatoid granulomatosis. (668421)
1978
50
Lymphomatoid granulomatosis after immunosuppression for pemphigus. (686725)
1978

Variations for Lymphomatoid Granulomatosis

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Expression for genes affiliated with Lymphomatoid Granulomatosis

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Search GEO for disease gene expression data for Lymphomatoid Granulomatosis.

Pathways for genes affiliated with Lymphomatoid Granulomatosis

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Pathways related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.3IFNA1, IFNA2
2
Show member pathways
9.3IFNA1, IFNA2
3
Show member pathways
Type III interferon signaling38
9.3IFNA1, IFNA2
4
Show member pathways
9.3IFNA1, IFNA2
59.3IFNA1, IFNA2
6
Show member pathways
Immune response CD16 signaling in NK cells60
9.3IFNA2, IFNA1
79.3IFNA2, IFNA1
8
Show member pathways
9.3IFNA2, IFNA1
99.3IFNA2, IFNA1
109.3IFNA2, IFNA1
11
Show member pathways
9.3IFNA2, IFNA1
129.3IFNA2, IFNA1
139.3IFNA2, IFNA1
14
Show member pathways
9.3IFNA2, IFNA1
159.3IFNA2, IFNA1
16
Show member pathways
9.3IFNA2, IFNA1
179.3IFNA2, IFNA1
189.0CXCL9, IFNA2
19
Show member pathways
8.5CXCL9, IFNA1, IFNA2
20
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.5IFNA2, IFNA1, CXCL9

Compounds for genes affiliated with Lymphomatoid Granulomatosis

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Compounds related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1pegasys459.8IFNA2, IFNA1
2entecavir459.8IFNA2, IFNA1
3famciclovir45 1310.8IFNA1, IFNA2
4n-phosphonacetyl-l-aspartate459.8IFNA1, IFNA2
5intron a459.8IFNA1, IFNA2
6mizoribine459.8IFNA1, IFNA2
7pentostatin45 61 30 1312.8IFNA1, IFNA2
8lomustine45 1310.8IFNA1, IFNA2
9anagrelide45 1310.8IFNA1, IFNA2
105-deoxy-5-fluorouridine459.8IFNA2, IFNA1
11adefovir459.8IFNA1, IFNA2
12amantadine45 1310.7IFNA2, IFNA1
13didanosine45 51 1311.7IFNA2, IFNA1
14acitretin45 1310.7IFNA2, IFNA1
15busulfan45 51 1311.7IFNA1, IFNA2
16levamisole45 1310.7IFNA1, IFNA2
17dacarbazine45 1310.7IFNA2, IFNA1
18acyclovir45 1310.7IFNA1, IFNA2
19temozolomide45 1310.7IFNA2, IFNA1
20imiquimod45 61 30 1312.7IFNA2, IFNA1
21isotretinoin45 1310.7IFNA1, IFNA2
22bcnu459.7IFNA1, IFNA2
23lamivudine45 51 1311.7IFNA2, IFNA1
242,5-oligoadenylate459.7IFNA1, IFNA2
25ursodeoxycholic acid45 26 1311.7IFNA2, IFNA1
26mitoxantrone45 51 1311.7IFNA2, IFNA1
27leucovorin45 51 1311.7IFNA1, IFNA2
28ribavirin45 51 1311.7IFNA2, IFNA1
29melphalan45 51 1311.7IFNA2, IFNA1
30neopterin459.6IFNA2, IFNA1
31rituximab45 51 1311.6IFNA1, IFNA2
32vinblastine45 51 1311.6IFNA2, IFNA1
33bleomycin45 1310.6IFNA2, IFNA1
34thalidomide45 51 61 1312.6IFNA1, IFNA2
35zidovudine45 51 1311.6IFNA2, IFNA1
36polyethylene glycol459.6IFNA2, IFNA1
37hydroxyurea45 51 1311.6IFNA2, IFNA1
38nucleoside459.5IFNA1, IFNA2
39thymidylate459.5IFNA2, IFNA1
40vincristine45 51 1311.5IFNA2, IFNA1
41ccl345 3010.5CXCL9, IFNA1
42cytarabine45 51 1311.4IFNA1, IFNA2
43prednisolone45 30 1311.4IFNA2, IFNA1
445fluorouracil459.2IFNA1, IFNA2
45rantes459.1IFNA1, CXCL9
46retinoid459.0IFNA2, IFNA1
47ifn-alpha459.0IFNA2, IFNA1, CXCL9
48cyclophosphamide45 51 1311.0CXCL9, IFNA1, IFNA2
49vegf458.9IFNA2, IFNA1, CXCL9
50tyrosine458.5IFNA2, IFNA1, CXCL9

GO Terms for genes affiliated with Lymphomatoid Granulomatosis

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Biological processes related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00069549.0IFNA2, CXCL9
2defense response to virusGO:00516078.9IFNA2, CXCL9
3cell-cell signalingGO:00072678.7IFNA2, CXCL9

Molecular functions related to Lymphomatoid Granulomatosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051259.0IFNA2, CXCL9

Products for genes affiliated with Lymphomatoid Granulomatosis

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Sources for Lymphomatoid Granulomatosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet