MCID: LYM052
MIFTS: 40

Lymphomatoid Papulosis malady

Rare diseases, Skin diseases, Blood diseases, Cancer diseases, Immune diseases categories

Aliases & Classifications for Lymphomatoid Papulosis

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Sources:
65UMLS, 45NIH Rare Diseases, 47Novoseek, 51Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all sources

Aliases & Descriptions for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 45 47 51 65
Lyp 45 51
 
X-Linked Lymphoproliferative Disorder 65
Hodgkin's Disease, Nodular Sclerosis 65


Classifications:



Characteristics (Orphanet epidemiological data):

51
lymphomatoid papulosis:
Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Orphanet51 98842
ICD10 via Orphanet28 C86.6
MESH via Orphanet37 D017731
UMLS via Orphanet66 C0206182
ICD1027 L41.2

Summaries for Lymphomatoid Papulosis

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NIH Rare Diseases:45 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards based summary: Lymphomatoid Papulosis, also known as lyp, is related to alk-negative anaplastic large cell lymphoma and lymphatic system disease. An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin)), and among its related pathways are IL-10 Pathway and Downstream signaling in naive CD8+ T cells. Affiliated tissues include skin, t cells and bone, and related mouse phenotypes are tumorigenesis and mortality/aging.

Wikipedia:68 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

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Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 108)
idRelated DiseaseScoreTop Affiliating Genes
1alk-negative anaplastic large cell lymphoma30.6ALK, NPM1
2lymphatic system disease30.0ALK, GZMB, NPM1, TIA1
3lymphoma, non-hodgkin29.9ALK, FAS, GZMB, NPM1
4anaplastic large cell lymphoma11.0
5mycosis fungoides10.9
6pityriasis lichenoides10.8
7cutaneous t cell lymphoma10.8
8primary cutaneous anaplastic large cell lymphoma10.7
9pityriasis lichenoides et varioliformis acuta10.6
10histiocytosis10.6
11hypereosinophilic syndrome10.5
12leukemia10.5
13chronic lymphocytic leukemia10.4
14pyoderma10.4
15ichthyosis10.4
16lymphopenia10.4
17rheumatoid arthritis10.2
18burkitt lymphoma10.2
19multiple myeloma10.2
20arthritis10.2
21b-cell lymphomas10.2
22crohn's disease10.2
23hematologic cancer10.2
24lymphomatoid granulomatosis10.2
25peripheral t-cell lymphoma10.2
26retinal vein occlusion10.2
27skin conditions10.2
28skin disease10.2
29gamma chain deficiency10.2
30langerhans-cell histiocytosis10.2
31macroglobulinemia10.2
32lethal midline granuloma10.2
33pyoderma gangrenosum10.2
34reticulosarcoma10.2
35lymphosarcoma10.2
36proctitis10.2
37adult lymphoma10.2
38molluscum contagiosum10.2
39tuberculum sellae meningioma10.2
40juvenile rheumatoid arthritis10.2
41amyloidosis10.2
42basal cell carcinoma10.2
43eosinophilia10.2
44hypersensitivity reaction type iv disease10.2
45keratoacanthoma10.2
46learning disability10.2
47lymphatic system cancer10.2
48myeloma10.2
49nephrotic syndrome10.2
50primary systemic mycosis10.2

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Symptoms for Lymphomatoid Papulosis

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Drugs & Therapeutics for Lymphomatoid Papulosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell LymphomaCompletedNCT00099255Phase 2
2SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)RecruitingNCT01352520Phase 2

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

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Anatomical Context for Lymphomatoid Papulosis

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MalaCards organs/tissues related to Lymphomatoid Papulosis:

33
Skin, T cells, Bone, Bone marrow, B cells, Tongue, Monocytes

Animal Models for Lymphomatoid Papulosis or affiliated genes

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MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.1FAS, FASLG, GZMB, NPM1
2MP:00107687.3FAS, FASLG, GZMB, NPM1, TIA1, TYK2
3MP:00053877.1FAS, FASLG, GZMB, NPM1, TIA1, TYK2
4MP:00053976.9FAS, FASLG, GZMB, NPM1, TIA1, TYK2

Publications for Lymphomatoid Papulosis

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Articles related to Lymphomatoid Papulosis:

(show top 50)    (show all 370)
idTitleAuthorsYear
1
Lymphomatoid papulosis associated with follicular B-cell lymphoma in lymph nodes. (26282183)
2015
2
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. (24668491)
2014
3
Tattoos and coincidental skin conditions: the example of lymphomatoid papulosis. (24841722)
2014
4
Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. (25242096)
2014
5
Steroid-Resistant Localized Lymphomatoid Papulosis Treated with Local Bath-PUVA Therapy. (23716855)
2013
6
Regional lymphomatoid papulosis successfully controlled by interferon I+-2b and nitrogen mustard solution. (23981641)
2013
7
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis. (23648461)
2013
8
A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection. (22715829)
2012
9
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (21841159)
2011
10
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
11
Type B follicular lymphomatoid papulosis. (20666192)
2010
12
Solitary oral ulceration as the first appearance of lymphomatoid papulosis: a diagnostic challenge. (19486068)
2010
13
Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma. (19969358)
2010
14
Acral lymphomatoid papulosis. (20159331)
2010
15
Investigation on clinicopathologic features of lymphomatoid papulosis]. (20078970)
2009
16
Dermoscopy of lymphomatoid papulosis. (19687447)
2009
17
Clinical, histopathologic, and immunophenotypic features of lymphomatoid papulosis with CD8 predominance in 14 pediatric patients. (19577330)
2009
18
Prognosis of lymphomatoid papulosis. (16951399)
2006
19
Three cases of lymphomatoid papulosis with a CD56+ immunophenotype. (17052504)
2006
20
Two cases of lymphomatoid papulosis in children. (12657013)
2003
21
Retinal vein occlusion in lymphomatoid papulosis. (12510725)
2002
22
Localized lymphomatoid papulosis. (11834855)
2002
23
Pseudocarcinomatous change in lymphomatoid papulosis and primary cutaneous CD30+ lymphoma: a clinicopathologic and immunohistochemical study of 6 patients. (11174381)
2001
24
Lymphomatoid papulosis with a natural killer-cell phenotype. (11531801)
2001
25
Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligand. (11594583)
2001
26
Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses. (11168749)
2001
27
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
28
Lymphomatoid papulosis and progression to T-cell immunoblastic lymphoma. (9643341)
1998
29
Lymphomatoid papulosis and FK 506. (9159004)
1997
30
Is it lymphoma or lymphomatoid papulosis? (9146539)
1997
31
Absence of HTLV-1 proviral sequences in patients with lymphomatoid papulosis. (9406828)
1997
32
A papulonecrotic eruption in a young man. Lymphomatoid papulosis. (9371032)
1997
33
The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis. (8618007)
1996
34
Cytogenetic findings in regressing skin lesions of lymphomatoid papulosis. (7697626)
1995
35
Hydroa vacciniforme-like lymphomatoid papulosis in a Japanese child: a new subset. (7829745)
1995
36
Lymphomatoid papulosis. (8113450)
1994
37
Lymphomatoid papulosis followed by acute myeloblastic leukemia. (8391031)
1993
38
Lymphomatoid papulosis followed by large-cell lymphoma: immunophenotypical and genotypical analysis. (1645581)
1991
39
Lymphomatoid papulosis update. A historical perspective. (2679400)
1989
40
Lymphomatoid papulosis. A follow-up study of 30 patients. (2889756)
1987
41
Abnormal T-lymphocytes in lymphomatoid papulosis. A cytomorphological study with a reconstruction of a major part of the cell differentiation cycle. (2883764)
1987
42
Atypical cells in lymphomatoid papulosis express the Hodgkin cell-associated antigen Ki-1. (2427610)
1986
43
Hodgkin's disease complicating lymphomatoid papulosis. (3911804)
1985
44
DNA analysis by flow cytometry in lymphomatoid papulosis. (6641008)
1983
45
Lymphomatoid papulosis. Case report providing evidence for a monocyte-macrophage origin of the atypical cells. (6883285)
1983
46
Lymphomatoid papulosis. Macaulay's disease. (7270814)
1981
47
Cutaneous lesions of lymphomatoid granulomatosis. Comparison with lymphomatoid papulosis. (7270809)
1981
48
Lymphomatoid papulosis and other pseudomalignancies of the skin. (576506)
1977
49
Lymphomatoid papulosis eventuating in mycosis fungoides. (4479691)
1974
50
Lymphomatoid papulosis. An electron microscope study of the acute and healing stages with demonstration of paramyxovirus-like particles. (4117077)
1972

Variations for Lymphomatoid Papulosis

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Cosmic variations for Lymphomatoid Papulosis:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
110812TP53haematopoietic and lymphoid tissue,skin,lymphoid neoplasm,lymphomatoid papulosis3
245446TP53haematopoietic and lymphoid tissue,skin,lymphoid neoplasm,lymphomatoid papulosis3

Expression for genes affiliated with Lymphomatoid Papulosis

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Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for genes affiliated with Lymphomatoid Papulosis

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Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TIA1, TYK2
2
Show member pathways
9.3FASLG, GZMB
39.2ALK, NPM1, TYK2
49.1FAS, FASLG
59.1FAS, FASLG
6
Show member pathways
8.9FASLG, GZMB, TYK2
7
TNF Signaling (sino)
Show member pathways
8.8FASLG, GZMB, TYK2
8
Show member pathways
8.5FAS, FASLG, GZMB
9
Show member pathways
8.5FAS, FASLG, GZMB
10
Apoptosis (WikiPathways)
Show member pathways
8.5FAS, FASLG, GZMB
11
Show member pathways
8.5FAS, FASLG, GZMB
12
Show member pathways
8.5FAS, FASLG, GZMB
13
Show member pathways
8.5FAS, FASLG, GZMB
148.1FAS, FASLG, GZMB, TYK2
158.0FAS, FASLG, GZMB, TIA1

GO Terms for genes affiliated with Lymphomatoid Papulosis

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Cellular components related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:00160207.3ALK, FAS, FASLG, GZMB, NPM1, TYK2

Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00069259.7FAS, FASLG
2necroptotic signaling pathwayGO:00975279.7FAS, FASLG
3activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:00972969.7FAS, FASLG
4regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.7FAS, FASLG
5extrinsic apoptotic signaling pathwayGO:00971919.6FAS, FASLG
6regulation of necrotic cell deathGO:00109399.6FAS, FASLG
7necroptotic processGO:00702669.6FAS, FASLG
8programmed necrotic cell deathGO:00973009.6FAS, FASLG
9extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.6FAS, FASLG
10negative regulation of cysteine-type endopeptidase activity involved in apoptotic processGO:00431549.2FAS, FASLG
11programmed cell deathGO:00125018.2FAS, FASLG, GZMB
12apoptotic processGO:00069158.0FAS, FASLG, GZMB, TIA1

Sources for Lymphomatoid Papulosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet