LYP
MCID: LYM052
MIFTS: 43

Lymphomatoid Papulosis (LYP) malady

Skin diseases, Blood diseases, Cancer diseases, Immune diseases categories

Summaries for Lymphomatoid Papulosis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards: Lymphomatoid Papulosis, also known as LYP, is related to anaplastic large cell lymphoma and mycosis fungoides. An important gene associated with Lymphomatoid Papulosis is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds cycloheximide and cxcl9 have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia:63 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Aliases & Classifications for Lymphomatoid Papulosis

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42NIH Rare Diseases, 44Novoseek, 48Orphanet, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Skin diseases, Blood diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
lymphomatoid papulosis:
Age of onset: Adulthood


Aliases & Descriptions:

lymphomatoid papulosis 42 44 48 60
lyp 42


External Ids:

MESH via Orphanet35 D017731
ICD10 via Orphanet26 C86.6
SNOMED-CT via Orphanet57 31047003, 397353001
UMLS via Orphanet61 C0206182
ICD1025 L41.2

Related Diseases for Lymphomatoid Papulosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 150)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma31.3JUNB, CCR4, CCL17, GZMB, TNFRSF8, CLU
2mycosis fungoides31.2CCR4, CCR3, GZMB, TNFRSF8, CCL17, TIA1
3cutaneous t cell lymphoma31.0GZMB, TNFRSF8, FAS, TRB, CXCR3, TIA1
4hodgkin's lymphoma30.9JUNB, CCL17, GZMB, TIA1, TNFRSF8, CCR4
5lymphopenia30.5FASLG, B2M, FAS
6thymoma30.2TRB
7amyloidosis30.2CLU, B2M
8multiple myeloma30.2B2M, IRF4
9eosinophilia30.2CCR3, PDGFRA, CCL17, CCR4
10acute leukemia30.2CD7, NPM1, TRB
11myeloma30.2TNFRSF8, ALK, IRF4, TRB, FAS, B2M
12arthritis30.2CCR3, B2M, TRB, HBB, CLU, CXCR3
13rheumatoid arthritis30.1CD7, JUNB, CCR4, CCR3, GZMB, TNFRSF8
14leukemia30.1TRB, ALK, CXCR3, HBB, CD7, B2M
15graves' disease30.0TRB, FASLG, FAS, CXCR3
16histiocytosis10.5
17pediatric lymphoma10.3
18pyoderma10.3
19crohn's disease10.1
20molluscum contagiosum10.1
21proctitis10.1
22lethal midline granuloma10.1
23macroglobulinemia10.1
24tuberculum sellae meningioma10.1
25nevoid basal cell carcinoma syndrome10.1
26juvenile rheumatoid arthritis10.1
27pyoderma gangrenosum10.1
28basal cell carcinoma10.1
29breast disease10.1
30keratoacanthoma10.1
31langerhans-cell histiocytosis10.1
32meningioma10.1
33nephrotic syndrome10.1
34retinal vein occlusion10.1
35retinitis10.1
36scabies10.1
37panniculitis10.0TIA1
38cervical intraepithelial neoplasia10.0GZMB
39thyroiditis10.0FASLG
40bronchiolitis obliterans10.0CXCR3
41polymyositis10.0GZMB
42human immunodeficiency virus infectious disease10.0FASLG
43pneumonia10.0CCL17
44neuroblastoma10.0ALK
45myositis10.0GZMB
46oral cancer10.0FASLG
47esophagitis10.0CCR3
48vascular disease10.0FASLG
49splenomegaly10.0FAS
50hemophagocytic lymphohistiocytosis10.0GZMB

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Clinical Features for Lymphomatoid Papulosis

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Drugs & Therapeutics for Lymphomatoid Papulosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lymphomatoid Papulosis

Drug clinical trials:

Search ClinicalTrials for Lymphomatoid Papulosis

Search NIH Clinical Center for Lymphomatoid Papulosis

Search CenterWatch for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

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Anatomical Context for Lymphomatoid Papulosis

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32MalaCards
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MalaCards organs/tissues related to Lymphomatoid Papulosis:

32
Skin

Animal Models for Lymphomatoid Papulosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6FAS, FASLG, CXCR3, ACVRL1, PDGFRA, TRB
2MP:00053678.6TRB, CLU, HBB, JUNB
3MP:00036318.2NPM1, TRB, HBB, CLU, ACVRL1, FAS
4MP:00020068.0JUNB, PDGFRA, NPM1, FASLG, TRB, CXCR3
5MP:00053707.9NPM1, ACVRL1, HBB, FAS, B2M, FASLG
6MP:00053767.7HBB, ACVRL1, CXCR3, B2M, CLU, JUNB
7MP:00107717.4JUNB, FASLG, TRB, HBB, FAS, NPM1
8MP:00053856.7NPM1, PDGFRA, JUNB, FAS, B2M, TRB
9MP:00107686.4FASLG, TIA1, PDGFRA, NPM1, FAS, TRB
10MP:00053846.1FAS, CD7, TRB, B2M, FASLG, CXCR3
11MP:00053974.9FAS, NPM1, IRF4, TNFRSF8, FASLG, B2M
12MP:00053874.5FAS, IRF4, NPM1, FASLG, B2M, TRB

Publications for Lymphomatoid Papulosis

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Genetic Variations for Lymphomatoid Papulosis

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Expression for genes affiliated with Lymphomatoid Papulosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphomatoid Papulosis

Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for genes affiliated with Lymphomatoid Papulosis

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Sources:
53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems, 29KEGG, 51QIAGEN, 4Cell Signaling Technology, 55SinoBiological
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Pathways related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0FAS, FASLG
210.0FAS, FASLG
3
Apoptosis and survival Caspase cascade
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9.8FASLG, FAS, GZMB
4
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9.8FASLG, FAS, GZMB
59.7HBB, FASLG, FAS
6
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9.5GZMB, IRF4, FAS, FASLG
7
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9.5GZMB, FAS, FASLG, B2M
8
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9.4CCR4, CCL17, CCR3, CXCR3
99.4CXCR3, CCR3, CCL17, CCR4
10
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9.3JUNB, IRF4, FASLG
11
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9.2FASLG, FAS, NPM1, PDGFRA
12
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9.2FASLG, FAS, GZMB, JUNB
139.1JUNB, GZMB, FASLG, B2M
149.0FASLG, FAS, PDGFRA, JUNB
15
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8.9GZMB, FASLG, B2M, TRB
168.8JUNB, GZMB, FAS, FASLG, B2M
17
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8.8TNFRSF8, NPM1, FAS, FASLG, B2M
18
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8.5CCR4, CCL17, CCR3, PDGFRA, TNFRSF8, CXCR3
19
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7.8ALK, CCR4, CCL17, CCR3, PDGFRA, TNFRSF8
20
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7.7JUNB, CCR4, CCL17, CCR3, PDGFRA, TNFRSF8
21
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7.7JUNB, CCR4, CCL17, CCR3, PDGFRA, TNFRSF8

Compounds for genes affiliated with Lymphomatoid Papulosis

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7FASLG
2cxcl92810.3CCR3, CXCR3
3cxcl112810.3CXCR3, CCR3
4cxcl102810.3CCR3, CXCR3
5butyrate4410.3B2M, CCR3
6ccl112810.2CXCR3, CCR3
7ccl132810.2CCR3, CXCR3
8ccl52810.1CCR3, CXCR3
9concanamycin a44 5911.1GZMB, FAS, FASLG
10ccl72810.1CXCR3, CCR3
11larc4410.0CCL17, CCR4, CXCR3
12rantes4410.0GZMB, CXCR3, FAS, FASLG
13dutp4410.0FASLG, CLU, FAS
14(glc)44410.0FASLG, FAS
152-chlorodeoxyadenosine449.9B2M, FASLG, FAS
16tarc449.8CCR4, CXCR3, CCL17, CCR3
17ccl344 2810.8CCR4, CCR3, CXCR3, CCL17
18ccl444 2810.8CCL17, CCR4, CCR3, CXCR3
19sodium nitroprusside449.8CXCR3, FAS, B2M, FASLG
20tgf beta1449.7FASLG, FAS, PDGFRA, ACVRL1
21prednisolone44 28 1111.7CCR4, GZMB, TIA1, FAS
22tacrolimus44 49 1111.7FASLG, CXCR3, CCL17, GZMB
23camptothecin44 59 1111.6CLU, FAS, FASLG, NPM1
24agarose449.5FASLG, GZMB, NPM1, FAS, CLU
25heparin44 28 11 2412.5GZMB, FAS, FASLG, CLU, CXCR3, CCR3
26morphine44 49 28 1112.5FAS, CCR3, FASLG, JUNB
27tamoxifen44 49 28 1112.5CLU, HBB, JUNB, FASLG
28rapamycin449.3NPM1, FASLG, FAS, GZMB, PDGFRA
29serine449.2ALK, ACVRL1, CXCR3, CLU, HBB, B2M
30doxorubicin44 49 1111.1ALK, NPM1, FAS, FASLG, B2M, CLU
31aspartate449.0ALK, HBB, B2M, FASLG, NPM1, PDGFRA
32genistein44 28 59 2 11 2414.0FAS, FASLG, B2M, CCR3, JUNB
33vegf448.9FAS, CLU, PDGFRA, B2M, FASLG, CXCR3
34dexamethasone44 49 28 1111.9JUNB, FAS, CCL17, CCR3, GZMB, CLU
35calcitriol44 59 11 2411.9PDGFRA, JUNB, CLU, B2M
36actinomycin d448.8CLU, FAS, JUNB, CCR3, FASLG, NPM1
37alanine448.8ALK, CCR3, GZMB, NPM1, HBB, FASLG
38lactate448.7CLU, GZMB, NPM1, FAS, FASLG, B2M
39phosphatidylinositol448.6FAS, JUNB, FASLG, CXCR3, ALK, PDGFRA
40cysteine448.6CLU, HBB, B2M, FASLG, FAS, NPM1
41[alcl]448.5ALK, ACVRL1, TIA1, CCR4, CCL17, GZMB
42atp44 289.4JUNB, GZMB, TIA1, PDGFRA, NPM1, CLU
43thymidine44 249.4CCR3, PDGFRA, TNFRSF8, FASLG, B2M, HBB
44zinc44 249.2TNFRSF8, CCR4, FASLG, CLU, HBB, NPM1
45cyclosporin a44 28 599.9TRB, B2M, GZMB, CCL17, TNFRSF8, FAS
46oligonucleotide447.8JUNB, GZMB, ACVRL1, CLU, HBB, TRB
47retinoic acid44 248.6B2M, JUNB, CLU, CCR4, FASLG, CCR3
48paraffin446.9TRB, B2M, FAS, NPM1, TIA1, FASLG
49tyrosine446.0JUNB, ALK, FASLG, CCR3, GZMB, PDGFRA
50calcium44 49 11 249.0CCR4, JUNB, CCL17, CCR3, PDGFRA, NPM1

GO Terms for genes affiliated with Lymphomatoid Papulosis

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16Gene Ontology
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Cellular components related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.6CCR4, CCR3, PDGFRA, FASLG, CXCR3, ACVRL1
2external side of plasma membraneGO:0098978.4CCR4, PDGFRA, FAS, FASLG, B2M, CXCR3

Biological processes related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FAS, FASLG
2retina vasculature development in camera-type eyeGO:06129810.1PDGFRA, ACVRL1
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.1FASLG, FAS
4chemotaxisGO:0069359.6CXCR3, CCR3, CCL17, CCR4
5positive regulation of NF-kappaB transcription factor activityGO:0510929.6ALK, CLU, NPM1
6elevation of cytosolic calcium ion concentrationGO:0072049.5CXCR3, PDGFRA, CCR3, CCR4
7positive regulation of apoptotic processGO:0430659.5TNFRSF8, FAS, FASLG, CLU
8inflammatory responseGO:0069549.3CXCR3, CCR3, CCL17, CCR4
9apoptotic processGO:0069159.1TIA1, GZMB, FAS, FASLG, CXCR3
10signal transductionGO:0071658.7TNFRSF8, NPM1, FAS, FASLG, ACVRL1, ALK

Molecular functions related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.8CCR3, CCR4
2chemokine receptor activityGO:0049509.5CXCR3, CCR3, CCR4
3protein bindingGO:0055156.1IRF4, PDGFRA, GZMB, CCR3, TIA1, JUNB

Products for genes affiliated with Lymphomatoid Papulosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphomatoid Papulosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet