MCID: LYM052
MIFTS: 45

Lymphomatoid Papulosis malady

Categories: Rare diseases, Skin diseases, Blood diseases, Immune diseases

Aliases & Classifications for Lymphomatoid Papulosis

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Sources:
46NIH Rare Diseases, 52Orphanet, 48Novoseek, 66UMLS, 29ICD10 via Orphanet, 38MESH via Orphanet, 67UMLS via Orphanet, 28ICD10
See all MalaCards sources

Aliases & Descriptions for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 46 52 48 66
Lyp 46 52
 
X-Linked Lymphoproliferative Disorder 66

Characteristics:

Orphanet epidemiological data:

52
lymphomatoid papulosis:
Inheritance: Not yet documented; Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet52 ORPHA98842
ICD10 via Orphanet29 C86.6
MESH via Orphanet38 D017731
UMLS via Orphanet67 C0206182
ICD1028 L41.2

Summaries for Lymphomatoid Papulosis

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NIH Rare Diseases:46 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards based summary: Lymphomatoid Papulosis, also known as lyp, is related to eosinophilia and lymphoma, and has symptoms including hepatomegaly An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin), and among its related pathways are Immune response_IL-12 signaling pathway and Tyrosine Kinases / Adaptors. Affiliated tissues include skin, t cells and bone marrow, and related mouse phenotypes are respiratory system and neoplasm.

Wikipedia:69 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

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Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia30.9GZMB, TIA1
2lymphoma10.9
3male infertility10.7GZMB, TIA1
4multiple carboxylase deficiency, biotin responsive10.7CD7, TNFRSF8
5anaplastic large cell lymphoma10.6
6upper lip cancer10.6ALK, TNFRSF8
7pityriasis rotunda10.6CD7, TNFRSF8
8clivus chordoma10.6GZMB, TIA1
9mycosis fungoides10.6
10panniculitis10.6CD7, TNFRSF8
11congenital sucrase-isomaltase deficiency with starch intolerance10.6ALK, NPM1
12gray zone lymphoma10.5GZMB, TIA1
13polycystic ovary syndrome10.5ALK, GZMB, TIA1
14pityriasis lichenoides10.5
15limb dystonia10.5GZMB, TIA1
16lacrimal passage granuloma10.5GZMB, PDGFRA, TIA1
17drug-induced hepatitis10.4ALK, IRF4, TNFRSF8
18foxg1 syndrome10.4JUN, TNFRSF8
19cutaneous t cell lymphoma10.4
20breast fibroadenosis10.4GZMB, TIA1
21pseudotyphus of california10.4CD7, GZMB, TIA1
22marantic endocarditis10.4CD7, TIA1, TNFRSF8
23trigeminal nerve disease10.4FASLG, GZMB
24lateral medullary syndrome10.4PDGFRA, TNFRSF8
25primary cutaneous anaplastic large cell lymphoma10.4
26subependymal nodular heterotopia10.3GZMB, TIA1, TRG
27pityriasis lichenoides et varioliformis acuta10.3
28sezary's disease10.3ALK, GZMB, NPM1, TIA1
29trachea adenoid cystic carcinoma10.3ALK, PDGFRA
30lymphopenia10.3
31histiocytosis10.3
32testicular malignant germ cell cancer10.2FASLG, GZMB, TIA1
33leukemia10.2
34hypereosinophilic syndrome10.2
35estrogen-receptor positive breast cancer10.1ALK, GZMB, NPM1, TIA1, TNFRSF8
36nutritional deficiency disease10.1HBB, TNFRSF8
37multiple myeloma10.1
38chronic lymphocytic leukemia10.1
39myeloma10.1
40pyoderma10.1
41alcoholic hepatitis10.0CD7, FAS, TNFRSF8
42pediatric systemic lupus erythematosus10.0FAS, FASLG
43juvenile retinoschisis9.9FAS, TYK2
44rheumatoid arthritis9.9
45arthritis9.9
46b-cell lymphomas9.9
47crohn's disease9.9
48lymphomatoid granulomatosis9.9
49peripheral t-cell lymphoma9.9
50retinal vein occlusion9.9

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Symptoms for Lymphomatoid Papulosis

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UMLS symptoms related to Lymphomatoid Papulosis:


hepatomegaly

Drugs & Therapeutics for Lymphomatoid Papulosis

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell LymphomaCompletedNCT00099255Phase 2
2SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)Active, not recruitingNCT01352520Phase 2
3Tissue Repository: CTCL Collection ProtocolNot yet recruitingNCT02840747

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

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Anatomical Context for Lymphomatoid Papulosis

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MalaCards organs/tissues related to Lymphomatoid Papulosis:

34
Skin, T cells, Bone marrow, Breast, Bone, B cells, Tongue

Animal Models for Lymphomatoid Papulosis or affiliated genes

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MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.3ALK, CASP3, CCR3, FAS, FASLG, JUN
2MP:00020068.0ALK, FAS, FASLG, IRF4, JUNB, NPM1
3MP:00107717.8ALK, CASP3, FAS, FASLG, JUN, JUNB
4MP:00053907.1ALK, CASP3, FAS, FASLG, JUN, JUNB
5MP:00053796.9ALK, CASP3, CD7, FAS, FASLG, JUN
6MP:00053875.7CASP3, CCR3, CD7, FAS, FASLG, IRF4
7MP:00053975.4CASP3, CCR3, CD7, FAS, FASLG, IRF4

Publications for Lymphomatoid Papulosis

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Articles related to Lymphomatoid Papulosis:

(show top 50)    (show all 389)
idTitleAuthorsYear
1
Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. (26960644)
2016
2
Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. (27461449)
2016
3
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review. (27138554)
2016
4
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature. (26763888)
2016
5
Lymphomatoid papulosis and fingolimod-A new connection? (26993118)
2016
6
Lymphomatoid papulosis in a young adult of African descent. (27051732)
2015
7
Recommendations for treatment of lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group. (25998985)
2015
8
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. (24668491)
2014
9
Tattoos and coincidental skin conditions: the example of lymphomatoid papulosis. (24841722)
2014
10
Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. (25242096)
2014
11
A Unique Case of Concurrent Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma and Lymphomatoid Papulosis in the Same Biopsy. (25382820)
2014
12
Regional lymphomatoid papulosis successfully controlled by interferon I+-2b and nitrogen mustard solution. (23981641)
2013
13
Ulcerated nodules on the oral mucosa and fingers: lymphomatoid papulosis, type A. (23165794)
2013
14
A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection. (22715829)
2012
15
In search of prognostic indicators for lymphomatoid papulosis: a retrospective study of 123 patients. (21982062)
2012
16
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
17
Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma. (19969358)
2010
18
Acral lymphomatoid papulosis. (20159331)
2010
19
Regional lymphomatoid papulosis in a child--treatment with a UVB phototherapy handpiece. (20482240)
2010
20
A variant of lymphomatoid papulosis simulating primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Description of 9 cases. (20661014)
2010
21
Dermoscopy of lymphomatoid papulosis. (19687447)
2009
22
Clinical, histopathologic, and immunophenotypic features of lymphomatoid papulosis with CD8 predominance in 14 pediatric patients. (19577330)
2009
23
Lymphomatoid papulosis while on efalizumab. (19700027)
2009
24
MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (18410414)
2008
25
Nevoid basal cell carcinoma syndrome associated with lymphomatoid papulosis. (12835561)
2003
26
Retinal vein occlusion in lymphomatoid papulosis. (12510725)
2002
27
Lymphomatoid papulosis with a natural killer-cell phenotype. (11531801)
2001
28
Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligand. (11594583)
2001
29
Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses. (11168749)
2001
30
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
31
Lymphomatoid papulosis and progression to T-cell immunoblastic lymphoma. (9643341)
1998
32
Lymphomatoid papulosis and FK 506. (9159004)
1997
33
Is it lymphoma or lymphomatoid papulosis? (9146539)
1997
34
Spectrum of CD30 lymphoproliferative diseases from lymphomatoid papulosis to anaplastic large cell lymphoma. (8970838)
1996
35
Cytogenetic findings in regressing skin lesions of lymphomatoid papulosis. (7697626)
1995
36
Hydroa vacciniforme-like lymphomatoid papulosis in a Japanese child: a new subset. (7829745)
1995
37
Symmetrical lymphomatoid papulosis masquerading as pyoderma chancriformis of the eyelids. (7742293)
1995
38
Lymphomatoid papulosis: a T-cell dyscrasia with a propensity to transform into malignant lymphoma. (7810940)
1995
39
Lymphomatoid papulosis. (8113450)
1994
40
Lethal midline granuloma (peripheral T-cell lymphoma) after lymphomatoid papulosis. (1322784)
1992
41
Clonal composition of T cells in lymphomatoid papulosis. (3544850)
1987
42
Clonal analysis of T cells in lymphomatoid papulosis. (3492673)
1987
43
Acyclovir in lymphomatoid papulosis and mycosis fungoides. (3723701)
1986
44
DNA analysis by flow cytometry in lymphomatoid papulosis. (6641008)
1983
45
Lymphomatoid papulosis. Case reports and literature review. (6824356)
1983
46
A case of lymphomatoid papulosis and systemic lymphoma. (7459273)
1981
47
Lymphomatoid papulosis and other pseudomalignancies of the skin. (576506)
1977
48
Cutaneous T cell lymphomas: mycosis fungoides, SAczary syndrome and lymphomatoid papulosis--Part I. (308870)
1977
49
Lymphomatoid papulosis. (931420)
1977
50
Lymphomatoid papulosis eventuating in mycosis fungoides. (4479691)
1974

Variations for Lymphomatoid Papulosis

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Expression for genes affiliated with Lymphomatoid Papulosis

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Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for genes affiliated with Lymphomatoid Papulosis

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Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 35)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6IRF4, JUN, TYK2
29.5ALK, NPM1, PDGFRA, TYK2
39.5CASP3, JUN, TYK2
4
Show member pathways
9.4FAS, FASLG, GZMB
59.4FAS, FASLG, HBB
69.3FAS, FASLG, JUN
79.3CD7, GZMB, IRF4
8
Show member pathways
9.3FASLG, GZMB, JUN, TYK2
9
Show member pathways
9.1JUN, JUNB, TYK2
109.1JUN, JUNB, TYK2
119.0JUN, JUNB, PDGFRA
12
Show member pathways
8.9CASP3, JUN, JUNB
138.7CASP3, FAS, FASLG, GZMB, TIA1
14
Show member pathways
8.7FASLG, GZMB, JUN, JUNB
15
Show member pathways
8.7CASP3, FAS, FASLG, JUN, NPM1
16
Show member pathways
8.7CASP3, FAS, FASLG, JUN, TYK2
17
Show member pathways
8.6CASP3, FAS, FASLG, GZMB, JUN
18
Show member pathways
8.6CASP3, FAS, FASLG, GZMB, JUN
19
Show member pathways
8.6CASP3, FAS, FASLG, GZMB, JUN
20
Show member pathways
8.6CASP3, JUN, JUNB, TYK2
218.6CASP3, FAS, FASLG, JUN, PDGFRA
228.6CASP3, FAS, FASLG, JUN, PDGFRA
23
Show member pathways
8.6CASP3, FAS, FASLG, JUN, PDGFRA
24
Show member pathways
8.5CASP3, FAS, FASLG, NPM1, TNFRSF8
258.4CASP3, FAS, JUN, JUNB
26
Show member pathways
8.4CASP3, FAS, FASLG, JUN, TNFRSF8
27
Show member pathways
8.3CASP3, FAS, FASLG, GZMB, IRF4, JUN
28
Show member pathways
8.2CASP3, FASLG, IRF4, JUN, JUNB
298.1FAS, FASLG, GZMB, IRF4, JUNB, TYK2
30
Show member pathways
7.8CASP3, FAS, FASLG, GZMB, JUN, JUNB
317.8CASP3, FAS, FASLG, JUN, JUNB, PDGFRA
32
Show member pathways
7.8CASP3, CCR3, FAS, FASLG, JUN, PDGFRA
33
Show member pathways
7.3ALK, CASP3, CCR3, FAS, FASLG, JUN
34
Show member pathways
7.1ALK, CASP3, CCR3, FAS, FASLG, JUNB
35
Show member pathways
6.7ALK, CASP3, CCR3, FAS, FASLG, JUN

GO Terms for genes affiliated with Lymphomatoid Papulosis

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Cellular components related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complexGO:00312649.6CASP3, FAS

Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.4FAS, FASLG
2necroptotic signaling pathwayGO:009752710.3FAS, FASLG
3activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:009729610.3FAS, FASLG
4response to growth factorGO:007084810.3FAS, FASLG
5regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204110.3FAS, FASLG
6positive regulation of DNA replicationGO:004574010.0JUN, NPM1, PDGFRA
7regulation of cell deathGO:00109419.8JUN, JUNB
8response to hydrogen peroxideGO:00425429.8CASP3, HBB, JUN
9cellular processGO:00099879.8JUN, JUNB
10positive regulation of neuron apoptotic processGO:00435259.7CASP3, FASLG, JUN
11activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.6CASP3, FAS, FASLG
12transmembrane receptor protein tyrosine kinase signaling pathwayGO:00071699.4ALK, CD7, TYK2
13regulation of cell proliferationGO:00421278.9FAS, JUN, JUNB, TYK2
14apoptotic signaling pathwayGO:00971908.9CASP3, FAS, FASLG, TNFRSF8
15apoptotic processGO:00069158.7CASP3, FAS, FASLG, GZMB, TIA1
16positive regulation of apoptotic processGO:00430658.5CASP3, FAS, FASLG, JUN, TNFRSF8
17response to lipopolysaccharideGO:00324967.8CASP3, FAS, FASLG, JUN, JUNB, TNFRSF8

Molecular functions related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1death receptor bindingGO:00051239.6CASP3, FASLG

Sources for Lymphomatoid Papulosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet