LYP
MCID: LYM052
MIFTS: 47

Lymphomatoid Papulosis (LYP) malady

Rare diseases, Skin diseases, Blood diseases, Cancer diseases, Immune diseases categories
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Summaries for Lymphomatoid Papulosis

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NIH Rare Diseases:42 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards based summary: Lymphomatoid Papulosis, also known as LYP, is related to anaplastic large cell lymphoma and mycosis fungoides. An important gene associated with Lymphomatoid Papulosis is TIA1 (TIA1 cytotoxic granule-associated RNA binding protein), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and Chemokine Signaling. The compounds larc and il 10 have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related mouse phenotypes are mortality/aging and immune system.

Wikipedia:65 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Aliases & Classifications for Lymphomatoid Papulosis

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Sources:
42NIH Rare Diseases, 44Novoseek, 48Orphanet, 62UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Lymphomatoid Papulosis, Aliases & Descriptions:

Name: Lymphomatoid Papulosis 42 44 48 62
 
Lyp 42 48 62


Classifications:



Characteristics (Orphanet epidemiological data):

48
lymphomatoid papulosis:
Age of onset: Variable; Age of death: Normal


External Ids:

MESH via Orphanet35 D017731
ICD10 via Orphanet26 C86.6
UMLS via Orphanet63 C0206182
ICD1025 L41.2

Related Diseases for Lymphomatoid Papulosis

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Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma30.8CCL17, CXCR3, ACVRL1, GZMB
2mycosis fungoides30.7TIA1, CXCR3, CCL17, GZMB
3hodgkin's lymphoma30.5GZMB, TIA1, CCL17
4cutaneous t cell lymphoma30.5CXCR3, GZMB, CCL17, TIA1
5leukemia30.2CXCR3, GZMB, TIA1
6peripheral t-cell lymphoma30.1GZMB, TIA1, CXCR3
7pityriasis lichenoides10.8
8primary cutaneous anaplastic large cell lymphoma10.7
9pityriasis lichenoides et varioliformis acuta10.6
10histiocytosis10.6
11hypereosinophilic syndrome10.5
12panniculitis10.4TIA1
13lymphopenia10.4
14paragonimiasis10.4CCL17
15chronic lymphocytic leukemia10.4
16pyoderma10.4
17myositis10.2GZMB
18arthritis10.2
19crohn's disease10.2
20lymphomatoid granulomatosis10.2
21multiple myeloma10.2
22retinal vein occlusion10.2
23rheumatoid arthritis10.2
24langerhans-cell histiocytosis10.2
25nevoid basal cell carcinoma syndrome10.2
26tuberculum sellae meningioma10.2
27juvenile rheumatoid arthritis10.2
28lethal midline granuloma10.2
29macroglobulinemia10.2
30molluscum contagiosum10.2
31pyoderma gangrenosum10.2
32proctitis10.2
33amyloidosis10.2
34basal cell carcinoma10.2
35eosinophilia10.2
36keratoacanthoma10.2
37meningioma10.2
38myeloma10.2
39nephrotic syndrome10.2
40retinitis10.2
41scabies10.2
42thymoma10.2
43transitional cell carcinoma10.2
44cluster headache10.2
45hydroa vacciniforme10.2
46pityriasis lichenoides chronica10.2
47ulcerative proctitis10.2
48cytomegalovirus infection10.2
49headache10.2
50alk-negative anaplastic large cell lymphoma10.2

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Symptoms for Lymphomatoid Papulosis

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Drugs & Therapeutics for Lymphomatoid Papulosis

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Drug clinical trials:

Search ClinicalTrials for Lymphomatoid Papulosis

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

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Anatomical Context for Lymphomatoid Papulosis

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MalaCards organs/tissues related to Lymphomatoid Papulosis:

32
Skin, T cells, Bone marrow, Bone, Heart, Colon, Breast, Monocytes, Tongue

Animal Models for Lymphomatoid Papulosis or affiliated genes

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MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.1GZMB, ACVRL1, CXCR3, TIA1
2MP:00053877.9TIA1, CXCR3, CCL17, GZMB
3MP:00053977.4GZMB, ACVRL1, CCL17, CXCR3, TIA1

Publications for Lymphomatoid Papulosis

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Articles related to Lymphomatoid Papulosis:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. (24668491)
2014
2
Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. (25242096)
2014
3
Steroid-Resistant Localized Lymphomatoid Papulosis Treated with Local Bath-PUVA Therapy. (23716855)
2013
4
Regional lymphomatoid papulosis successfully controlled by interferon I+-2b and nitrogen mustard solution. (23981641)
2013
5
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis. (23648461)
2013
6
A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection. (22715829)
2012
7
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (21841159)
2011
8
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
9
Type B follicular lymphomatoid papulosis. (20666192)
2010
10
Solitary oral ulceration as the first appearance of lymphomatoid papulosis: a diagnostic challenge. (19486068)
2010
11
Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma. (19969358)
2010
12
Acral lymphomatoid papulosis. (20159331)
2010
13
Investigation on clinicopathologic features of lymphomatoid papulosis]. (20078970)
2009
14
Dermoscopy of lymphomatoid papulosis. (19687447)
2009
15
Clinical, histopathologic, and immunophenotypic features of lymphomatoid papulosis with CD8 predominance in 14 pediatric patients. (19577330)
2009
16
Lymphomatoid papulosis while on efalizumab. (19700027)
2009
17
Prognosis of lymphomatoid papulosis. (16951399)
2006
18
Three cases of lymphomatoid papulosis with a CD56+ immunophenotype. (17052504)
2006
19
Two cases of lymphomatoid papulosis in children. (12657013)
2003
20
Retinal vein occlusion in lymphomatoid papulosis. (12510725)
2002
21
Localized lymphomatoid papulosis. (11834855)
2002
22
Pseudocarcinomatous change in lymphomatoid papulosis and primary cutaneous CD30+ lymphoma: a clinicopathologic and immunohistochemical study of 6 patients. (11174381)
2001
23
Lymphomatoid papulosis with a natural killer-cell phenotype. (11531801)
2001
24
Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligand. (11594583)
2001
25
Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses. (11168749)
2001
26
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
27
Lymphomatoid papulosis and progression to T-cell immunoblastic lymphoma. (9643341)
1998
28
Lymphomatoid papulosis and FK 506. (9159004)
1997
29
Is it lymphoma or lymphomatoid papulosis? (9146539)
1997
30
Absence of HTLV-1 proviral sequences in patients with lymphomatoid papulosis. (9406828)
1997
31
A papulonecrotic eruption in a young man. Lymphomatoid papulosis. (9371032)
1997
32
The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis. (8618007)
1996
33
Cytogenetic findings in regressing skin lesions of lymphomatoid papulosis. (7697626)
1995
34
Hydroa vacciniforme-like lymphomatoid papulosis in a Japanese child: a new subset. (7829745)
1995
35
Lymphomatoid papulosis. (8113450)
1994
36
Lymphomatoid papulosis followed by acute myeloblastic leukemia. (8391031)
1993
37
Lymphomatoid papulosis followed by large-cell lymphoma: immunophenotypical and genotypical analysis. (1645581)
1991
38
Lymphomatoid papulosis update. A historical perspective. (2679400)
1989
39
Lymphomatoid papulosis. A follow-up study of 30 patients. (2889756)
1987
40
Abnormal T-lymphocytes in lymphomatoid papulosis. A cytomorphological study with a reconstruction of a major part of the cell differentiation cycle. (2883764)
1987
41
Atypical cells in lymphomatoid papulosis express the Hodgkin cell-associated antigen Ki-1. (2427610)
1986
42
Hodgkin's disease complicating lymphomatoid papulosis. (3911804)
1985
43
DNA analysis by flow cytometry in lymphomatoid papulosis. (6641008)
1983
44
Lymphomatoid papulosis. Case report providing evidence for a monocyte-macrophage origin of the atypical cells. (6883285)
1983
45
Lymphomatoid papulosis. Macaulay's disease. (7270814)
1981
46
Cutaneous lesions of lymphomatoid granulomatosis. Comparison with lymphomatoid papulosis. (7270809)
1981
47
Lymphomatoid papulosis and other pseudomalignancies of the skin. (576506)
1977
48
Cutaneous T cell lymphomas: mycosis fungoides, SAczary syndrome and lymphomatoid papulosis--Part I. (308870)
1977
49
Lymphomatoid papulosis eventuating in mycosis fungoides. (4479691)
1974
50
Lymphomatoid papulosis. An electron microscope study of the acute and healing stages with demonstration of paramyxovirus-like particles. (4117077)
1972

Variations for Lymphomatoid Papulosis

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Expression for genes affiliated with Lymphomatoid Papulosis

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Expression patterns in normal tissues for genes affiliated with Lymphomatoid Papulosis

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Pathways for genes affiliated with Lymphomatoid Papulosis

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Compounds for genes affiliated with Lymphomatoid Papulosis

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Sources:
44Novoseek, 28IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank
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Compounds related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1larc449.7CXCR3, CCL17
2il 10449.7CXCR3, CCL17
3tarc449.7CCL17, CXCR3
4ccl344 2810.6CXCR3, CCL17
5ccl444 2810.6CCL17, CXCR3
6allergens449.6CCL17, CXCR3
7heparan sulfate44 2410.1GZMB, CXCR3
8tacrolimus44 50 1110.9CXCR3, CCL17, GZMB
9prednisolone44 28 1110.9GZMB, TIA1
10rantes448.9GZMB, CCL17, CXCR3
11dexamethasone44 50 28 1111.7GZMB, CCL17, CXCR3
12adp44 28 2410.7CXCR3, CCL17, ACVRL1
13nitric oxide44 24 1110.6GZMB, CCL17, CXCR3
14vegf448.6CXCR3, ACVRL1, GZMB
15[alcl]448.4GZMB, ACVRL1, CCL17, TIA1
16serine448.3GZMB, ACVRL1, CXCR3, TIA1

GO Terms for genes affiliated with Lymphomatoid Papulosis

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Biological processes related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of endothelial cell proliferationGO:0019379.3ACVRL1, CXCR3
2angiogenesisGO:0015259.3ACVRL1, CXCR3
3chemotaxisGO:0069359.1CCL17, CXCR3
4apoptotic processGO:0069158.6GZMB, CXCR3, TIA1

Products for genes affiliated with Lymphomatoid Papulosis

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Sources for Lymphomatoid Papulosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet