MCID: LYM052
MIFTS: 39

Lymphomatoid Papulosis malady

Categories: Rare diseases, Skin diseases, Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Lymphomatoid Papulosis

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Sources:
45NIH Rare Diseases, 47Novoseek, 51Orphanet, 65UMLS, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet, 27ICD10
See all MalaCards sources

Aliases & Descriptions for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 45 47 51 65
Lyp 45 51
 
X-Linked Lymphoproliferative Disorder 65

Characteristics:

Orphanet epidemiological data:

51
lymphomatoid papulosis:
Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet51 98842
ICD10 via Orphanet28 C86.6
MESH via Orphanet37 D017731
UMLS via Orphanet66 C0206182
ICD1027 L41.2
UMLS65 C0206182, C0549463

Summaries for Lymphomatoid Papulosis

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NIH Rare Diseases:45 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards based summary: Lymphomatoid Papulosis, also known as lyp, is related to hepatitis and pityriasis rotunda. An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin)), and among its related pathways are IL12-mediated signaling events and African trypanosomiasis. Affiliated tissues include skin, breast and heart, and related mouse phenotypes are tumorigenesis and respiratory system.

Wikipedia:68 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

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Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 312)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.4FAS, GZMB, TYK2
2pityriasis rotunda10.5CD7, TNFRSF8
3breast cancer10.5
4pityriasis lichenoides chronica10.5CD7, TNFRSF8
5nervous system disease10.5ALK, TNFRSF8
6alk-negative anaplastic large cell lymphoma10.4ALK, NPM1
7nodular nonsuppurative panniculitis10.4CD7, TNFRSF8
8prostatitis10.4
9pancreatitis10.4
10tertiary neurosyphilis10.4GZMB, TIA1
11necrotizing gastritis10.4GZMB, TIA1
12hepatocellular carcinoma10.4
13hepatitis b10.4
14melanoma10.4
15adenocarcinoma10.4
16ectopic thymus10.3GZMB, TIA1
17dilated cardiomyopathy10.3ALK, IRF4, TNFRSF8
18pediatric fibrosarcoma10.3PDGFRA, TNFRSF8
19colorectal cancer10.3
20liver disease10.3
21retinitis10.3
22tuberculosis10.3
23glioma10.3
24endotheliitis10.3
25anterior horn cell disease10.3ALK, PDGFRA
26small intestine cancer10.3GZMB, PDGFRA, TIA1
27bard1-related susceptibility to breast cancer10.3CXCR3, TRG
28cell type benign neoplasm10.2ALK, CD7, NPM1, TNFRSF8
29pol iii-related leukodystrophies10.2ALK, CXCR3, TIA1
30congenital sucrase-isomaltase deficiency without starch intolerance10.2ALK, CCR4
31schizophrenia10.2
32systemic lupus erythematosus10.2
33prostate cancer10.2
34obesity10.2
35renal cell carcinoma10.2
36osteoporosis10.2
37otitis media10.2
38cholangiocarcinoma10.2
39gastric cancer10.2
40leukemia10.2
41spinal cord injury10.2
42artery disease10.2
43lymphoma10.2
44portal hypertension10.2
45facial paralysis10.2
46hepatitis c10.2
47ovarian cancer10.2
48acute pancreatitis10.2
49mucinous adenocarcinoma10.2
50astrocytoma10.2

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Symptoms for Lymphomatoid Papulosis

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Drugs & Therapeutics for Lymphomatoid Papulosis

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Drugs for Lymphomatoid Papulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunologic FactorsPhase 218483
2ImmunoglobulinsPhase 24477
3Antibodies, MonoclonalPhase 22413
4AntibodiesPhase 24477

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell LymphomaCompletedNCT00099255Phase 2
2SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)RecruitingNCT01352520Phase 2

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

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Anatomical Context for Lymphomatoid Papulosis

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MalaCards organs/tissues related to Lymphomatoid Papulosis:

33
Skin, Breast, Heart, Liver, Brain, Lung, Prostate

Animal Models for Lymphomatoid Papulosis or affiliated genes

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MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3CXCR3, FAS, FASLG, IRF4, JUNB, NPM1
2MP:00053888.2ACVRL1, CCR3, CCR4, CXCR3, FAS, FASLG
3MP:00053678.1ACVRL1, CLU, CXCR3, FAS, FASLG, JUNB
4MP:00053975.4ACVRL1, CCL17, CCR3, CCR4, CD7, CXCR3
5MP:00053875.0CCL17, CCR3, CCR4, CD7, CLU, CXCR3

Publications for Lymphomatoid Papulosis

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Articles related to Lymphomatoid Papulosis:

(show top 50)    (show all 374)
idTitleAuthorsYear
1
Anti-neutrophil cytoplasmic antibody-associated pauci-immune glomerulonephritis in a patient with chronic lymphocytic leukaemia. (27095466)
2016
2
Brachydactyly Type C patient with compound heterozygosity for p.Gly319Val and p.Ile358Thr variants in the GDF5 proregion: benign variants or mutations? (25994865)
2015
3
Differences in cognitive function between patients with viral and alcoholic compensated liver cirrhosis. (26563125)
2015
4
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. (26061751)
2015
5
Relative influence of heritability, environment and genetics on serum sclerostin. (24136102)
2014
6
Estrogen receptor I+-coupled Bmi1 regulation pathway in breast cancer and its clinical implications. (24559156)
2014
7
Pathophysiology of human heart failure: importance of skeletal muscle myopathy and reflexes. (24293507)
2013
8
Notch inhibition restores TRAIL-mediated apoptosis via AP1-dependent upregulation of DR4 and DR5 TRAIL receptors in MDA-MB-231 breast cancer cells. (23686163)
2013
9
The Chronicity of Tonsillitis Is Significantly Correlated with an Increase in an LTi Cell Portion. (24022597)
2013
10
Breastfeeding follow-up in the treatment of children with phenylketonuria. (23306691)
2012
11
Plasminogen activator inhibitor-1 (PAI-1) expression in relation to hypoxia and oncoproteins in clinical cervical tumors. (23111469)
2012
12
Loss of expression and function of SOCS3 is an early event in HNSCC: altered subcellular localization as a possible mechanism involved in proliferation, migration and invasion. (23028842)
2012
13
Diagnostic difficulties in Krabbe disease: a report of two cases and review of literature. (23319190)
2012
14
Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition. (21536671)
2011
15
Diabetic neuropathy: cellular mechanisms as therapeutic targets. (21912405)
2011
16
Emergency transmediastinal pneumonectomy for scimitar syndrome. (23804893)
2010
17
Progressive myoclonic epilepsy as an adult-onset manifestation of Leigh syndrome due to m.14487T>C. (20019223)
2010
18
Association between Duffy antigen receptor for chemokines expression and levels of inflammation markers in sickle cell anemia patients. (20347396)
2010
19
Jejunal cancer in patients with familial adenomatous polyposis. (20399906)
2010
20
Genetic polymorphisms in UDP-glucuronosyltransferase 1A6 are not associated with NSAIDs-related peptic ulcer haemorrhage. (19799547)
2009
21
Primary cutaneous B-cell lymphomas - clinicopathological, prognostic and therapeutic characterisation of 54 cases according to the WHO-EORTC classification and the ISCL/EORTC TNM classification system for primary cutaneous lymphomas other than mycosis fungoides and Sezary syndrome. (18569636)
2008
22
Role of AMP-activated protein kinase in autophagy and proteasome function. (18328803)
2008
23
Expression of fibroblast growth factor receptor-4 in fetal kidneys and pathological kidneys of children]. (17448309)
2007
24
Effect of three different dental health preventive programmes on young adult individuals: a randomized, blinded, parallel group, controlled evaluation of oral hygiene behaviour on plaque and gingivitis. (17448044)
2007
25
Mutations in splicing factor PRPF3, causing retinal degeneration, form detrimental aggregates in photoreceptor cells. (17517693)
2007
26
Exercise-induced anaphylaxis and pregnancy. (17276667)
2007
27
Effects of a solubility enhancer on penetration of hydrophobic component in model adhesives into wet demineralized dentin. (17316781)
2007
28
High-dose intravenous immunoglobulin for the treatment of MuSK antibody-positive seronegative myasthenia gravis. (16876198)
2006
29
Regulation of poly(ADP-ribose) polymerase-1 by DNA structure-specific binding. (15737996)
2005
30
Allelic association analysis of the functional insertion/deletion polymorphism in the promoter region of the serotonin transporter gene in bipolar affective disorder. (16186633)
2005
31
Two-year interferon therapy with or without ribavirin in chronic delta hepatitis. (16218171)
2005
32
Case report: spinal cord infarction demonstrated on diffusion-weighted MR imaging with a single-shot fast spin-echo sequence. (12794608)
2003
33
Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia. (12396226)
2002
34
Human bronchial epithelial cells express PAR-2 with different sensitivity to thermolysin. (12003791)
2002
35
Ethnic differences and relationships in the oral pharmacokinetics of nifedipine and erythromycin. (11557910)
2001
36
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. (11303069)
2001
37
Pulmonary stenosis in recipient twins in twin-to-twin transfusion syndrome: report on 3 cases and review of literature. (10962042)
2000
38
Epidermal differentiation and basement membrane formation by HaCaT cells in surface transplants. (9587059)
1998
39
Cis-urocanic acid attenuates histamine receptor-mediated activation of adenylate cyclase and increase in intracellular Ca2+. (9681678)
1998
40
Interferon induction of TAP1: the phosphatase SHP-1 regulates crossover between the IFN-alpha/beta and the IFN-gamma signal-transduction pathways. (9776728)
1998
41
Breast imaging case of the day. Benign intraductal papilloma with focal atypical papillomatous hyperplasia. (9599399)
1998
42
How proteolysis drives the cell cycle. (8939846)
1996
43
Juvenile Huntington disease: CT and MR features. (7484624)
1995
44
Stimulation of human insulin receptor gene expression by retinoblastoma gene product. (7657628)
1995
45
Effect of thymopentin on peripheral blood T-lymphocytes subsets and on the clinical course of the disease in patients affected by multiple sclerosis. (1662825)
1991
46
Experimental membranous glomerulonephritis in rats induced with gp 700, a glomerular protein. (1707302)
1990
47
Klinefelter's syndrome in a boy with severe somatic and genital abnormalities. Case report. (904605)
1977
48
PNEUMATOSIS CYSTOIDES INTESTINALIS. (14180576)
1964
49
Cerebellar ataxia and neuronitis after exposure to DDT and lindane. (13408344)
1957
50

Variations for Lymphomatoid Papulosis

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Cosmic variations for Lymphomatoid Papulosis:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1COSM10812TP53haematopoietic and lymphoid tissue,skin,lymphoid neoplasm,lymphomatoid papulosis1

Expression for genes affiliated with Lymphomatoid Papulosis

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Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for genes affiliated with Lymphomatoid Papulosis

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Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.5FASLG, GZMB, TYK2
29.3FAS, FASLG, HBB
3
Show member pathways
9.3FAS, FASLG, GZMB
4
Show member pathways
9.2FASLG, IRF4, JUNB
5
Show member pathways
9.2FASLG, GZMB, JUNB
6
Show member pathways
9.0CCL17, CCR3, CCR4, CXCR3
79.0CD7, CXCR3, GZMB, IRF4
88.8FAS, FASLG, JUNB, PDGFRA
9
Show member pathways
7.4ACVRL1, CCL17, CCR3, CCR4, CXCR3, FAS
10
Show member pathways
7.0ACVRL1, ALK, CCL17, CCR3, CCR4, CXCR3
11
Show member pathways
6.7ACVRL1, ALK, CCL17, CCR3, CCR4, CXCR3
12
Show member pathways
6.7ACVRL1, ALK, CCL17, CCR3, CCR4, CXCR3

GO Terms for genes affiliated with Lymphomatoid Papulosis

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Cellular components related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical dendriteGO:00974409.7CLU, FAS

Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1type I interferon signaling pathwayGO:006033710.6IRF4, TYK2
2retina vasculature development in camera-type eyeGO:006129810.4ACVRL1, PDGFRA
3platelet aggregationGO:007052710.3HBB, PDGFRA
4necroptotic signaling pathwayGO:009752710.2FAS, FASLG
5transmembrane receptor protein tyrosine kinase signaling pathwayGO:000716910.1ALK, PDGFRA, TYK2
6response to growth factorGO:007084810.1FAS, FASLG
7necroptotic processGO:00702669.7FAS, FASLG
8cell surface receptor signaling pathwayGO:00071669.4CXCR3, FAS, FASLG
9chemokine-mediated signaling pathwayGO:00700989.0CCL17, CCR3, CCR4, CXCR3
10response to lipopolysaccharideGO:00324968.9FAS, FASLG, JUNB, TNFRSF8

Sources for Lymphomatoid Papulosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet