MCID: LYM052
MIFTS: 43

Lymphomatoid Papulosis malady

Rare diseases, Cancer diseases, Skin diseases, Blood diseases, Immune diseases categories

Aliases & Classifications for Lymphomatoid Papulosis

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Sources:
60UMLS, 41NIH Rare Diseases, 43Novoseek, 47Orphanet, 26ICD10 via Orphanet, 34MESH via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Lymphomatoid Papulosis, Aliases & Descriptions:

Name: Lymphomatoid Papulosis 41 43 47 60
Nodular Sclerosis Classical Hodgkin Lymphoma 41 47
Lyp 41 47
Primary Cutaneous Cd30+ T-Cell Lymphoproliferative Disease 41
 
Primary Cutaneous Ki-1+ T-Cell Lymphoproliferative Disease 41
X-Linked Lymphoproliferative Disorder 60
Hodgkin's Disease, Nodular Sclerosis 60


Classifications:



Characteristics (Orphanet epidemiological data):

47
lymphomatoid papulosis:
Age of onset: All ages; Age of death: normal life expectancy


External Ids:

Orphanet47 98843, 98842
ICD10 via Orphanet26 C81.1, C86.6
MESH via Orphanet34 D017731
UMLS via Orphanet61 C0206182
ICD1025 C81.1, L41.2

Summaries for Lymphomatoid Papulosis

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NIH Rare Diseases:41 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards based summary: Lymphomatoid Papulosis, also known as nodular sclerosis classical hodgkin lymphoma, is related to mycosis fungoides and anaplastic large cell lymphoma. An important gene associated with Lymphomatoid Papulosis is TIA1 (TIA1 cytotoxic granule-associated RNA binding protein), and among its related pathways are Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions and Chemokine Signaling. The compounds larc and il 10 have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone marrow, and related mouse phenotypes are mortality/aging and immune system.

Wikipedia:63 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

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Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 78)
idRelated DiseaseScoreTop Affiliating Genes
1mycosis fungoides30.7TIA1, CXCR3, CCL17, GZMB
2anaplastic large cell lymphoma30.7CCL17, CXCR3, ACVRL1, GZMB
3cutaneous t cell lymphoma30.5CXCR3, GZMB, CCL17, TIA1
4hodgkin lymphoma30.4GZMB, TIA1, CCL17
5leukemia30.2CXCR3, GZMB, TIA1
6peripheral t-cell lymphoma30.1GZMB, TIA1, CXCR3
7b-cell lymphomas30.0TIA1, CXCR3, CCL17, GZMB
8pityriasis lichenoides10.8
9primary cutaneous anaplastic large cell lymphoma10.7
10pityriasis lichenoides et varioliformis acuta10.6
11histiocytosis10.6
12hypereosinophilic syndrome10.5
13lymphopenia10.4
14panniculitis10.4TIA1
15diffuse large b-cell lymphoma10.4
16hodgkin's lymphoma, nodular sclerosis10.4
17mediastinitis10.4
18nodular lymphocyte predominant hodgkin lymphoma10.4
19paragonimiasis10.4CCL17
20chronic lymphocytic leukemia10.4
21pyoderma10.4
22myositis10.2GZMB
23rheumatoid arthritis10.2
24multiple myeloma10.2
25arthritis10.2
26crohn's disease10.2
27lymphomatoid granulomatosis10.2
28retinal vein occlusion10.2
29skin conditions10.2
30molluscum contagiosum10.2
31langerhans-cell histiocytosis10.2
32tuberculum sellae meningioma10.2
33juvenile rheumatoid arthritis10.2
34pyoderma gangrenosum10.2
35proctitis10.2
36lethal midline granuloma10.2
37macroglobulinemia10.2
38amyloidosis10.2
39basal cell carcinoma10.2
40eosinophilia10.2
41keratoacanthoma10.2
42myeloma10.2
43nephrotic syndrome10.2
44retinitis10.2
45scabies10.2
46thymoma10.2
47transitional cell carcinoma10.2
48cluster headache10.2
49hydroa vacciniforme10.2
50pityriasis lichenoides chronica10.2

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Symptoms for Lymphomatoid Papulosis

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Drugs & Therapeutics for Lymphomatoid Papulosis

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Drug clinical trials:

Search ClinicalTrials for Lymphomatoid Papulosis

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

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Anatomical Context for Lymphomatoid Papulosis

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MalaCards organs/tissues related to Lymphomatoid Papulosis:

31
T cells, Skin, Bone marrow, Bone, Heart, Colon, Breast, Monocytes, Tongue

Animal Models for Lymphomatoid Papulosis or affiliated genes

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MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.1GZMB, ACVRL1, CXCR3, TIA1
2MP:00053877.9TIA1, CXCR3, CCL17, GZMB
3MP:00053977.4GZMB, ACVRL1, CCL17, CXCR3, TIA1

Publications for Lymphomatoid Papulosis

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Articles related to Lymphomatoid Papulosis:

(show top 50)    (show all 360)
idTitleAuthorsYear
1
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. (24668491)
2014
2
Tattoos and coincidental skin conditions: the example of lymphomatoid papulosis. (24841722)
2014
3
Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. (25242096)
2014
4
Steroid-Resistant Localized Lymphomatoid Papulosis Treated with Local Bath-PUVA Therapy. (23716855)
2013
5
Regional lymphomatoid papulosis successfully controlled by interferon I+-2b and nitrogen mustard solution. (23981641)
2013
6
Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis. (23648461)
2013
7
A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection. (22715829)
2012
8
EORTC, ISCL, and USCLC consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (21841159)
2011
9
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
10
Type B follicular lymphomatoid papulosis. (20666192)
2010
11
Solitary oral ulceration as the first appearance of lymphomatoid papulosis: a diagnostic challenge. (19486068)
2010
12
Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma. (19969358)
2010
13
Acral lymphomatoid papulosis. (20159331)
2010
14
Investigation on clinicopathologic features of lymphomatoid papulosis]. (20078970)
2009
15
Dermoscopy of lymphomatoid papulosis. (19687447)
2009
16
Lymphomatoid papulosis while on efalizumab. (19700027)
2009
17
Prognosis of lymphomatoid papulosis. (16951399)
2006
18
Three cases of lymphomatoid papulosis with a CD56+ immunophenotype. (17052504)
2006
19
Two cases of lymphomatoid papulosis in children. (12657013)
2003
20
Retinal vein occlusion in lymphomatoid papulosis. (12510725)
2002
21
Localized lymphomatoid papulosis. (11834855)
2002
22
Pseudocarcinomatous change in lymphomatoid papulosis and primary cutaneous CD30+ lymphoma: a clinicopathologic and immunohistochemical study of 6 patients. (11174381)
2001
23
Lymphomatoid papulosis with a natural killer-cell phenotype. (11531801)
2001
24
Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligand. (11594583)
2001
25
Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses. (11168749)
2001
26
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
27
Lymphomatoid papulosis and progression to T-cell immunoblastic lymphoma. (9643341)
1998
28
Lymphomatoid papulosis and FK 506. (9159004)
1997
29
Is it lymphoma or lymphomatoid papulosis? (9146539)
1997
30
Absence of HTLV-1 proviral sequences in patients with lymphomatoid papulosis. (9406828)
1997
31
A papulonecrotic eruption in a young man. Lymphomatoid papulosis. (9371032)
1997
32
The dominant T cell clone is present in multiple regressing skin lesions and associated T cell lymphomas of patients with lymphomatoid papulosis. (8618007)
1996
33
Cytogenetic findings in regressing skin lesions of lymphomatoid papulosis. (7697626)
1995
34
Hydroa vacciniforme-like lymphomatoid papulosis in a Japanese child: a new subset. (7829745)
1995
35
Lymphomatoid papulosis. (8113450)
1994
36
Lymphomatoid papulosis followed by acute myeloblastic leukemia. (8391031)
1993
37
Lymphomatoid papulosis followed by large-cell lymphoma: immunophenotypical and genotypical analysis. (1645581)
1991
38
Lymphomatoid papulosis update. A historical perspective. (2679400)
1989
39
Lymphomatoid papulosis. A follow-up study of 30 patients. (2889756)
1987
40
Abnormal T-lymphocytes in lymphomatoid papulosis. A cytomorphological study with a reconstruction of a major part of the cell differentiation cycle. (2883764)
1987
41
Atypical cells in lymphomatoid papulosis express the Hodgkin cell-associated antigen Ki-1. (2427610)
1986
42
Hodgkin's disease complicating lymphomatoid papulosis. (3911804)
1985
43
DNA analysis by flow cytometry in lymphomatoid papulosis. (6641008)
1983
44
Lymphomatoid papulosis. Case report providing evidence for a monocyte-macrophage origin of the atypical cells. (6883285)
1983
45
Lymphomatoid papulosis. Macaulay's disease. (7270814)
1981
46
Cutaneous lesions of lymphomatoid granulomatosis. Comparison with lymphomatoid papulosis. (7270809)
1981
47
Lymphomatoid papulosis and other pseudomalignancies of the skin. (576506)
1977
48
Cutaneous T cell lymphomas: mycosis fungoides, SAczary syndrome and lymphomatoid papulosis--Part I. (308870)
1977
49
Lymphomatoid papulosis eventuating in mycosis fungoides. (4479691)
1974
50
Lymphomatoid papulosis. An electron microscope study of the acute and healing stages with demonstration of paramyxovirus-like particles. (4117077)
1972

Variations for Lymphomatoid Papulosis

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Cosmic variations for Lymphomatoid Papulosis:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
110812TP53haematopoietic and lymphoid tissue,skin,lymphoid neoplasm,lymphomatoid papulosis3
245446TP53haematopoietic and lymphoid tissue,skin,lymphoid neoplasm,lymphomatoid papulosis3

Expression for genes affiliated with Lymphomatoid Papulosis

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Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for genes affiliated with Lymphomatoid Papulosis

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Compounds for genes affiliated with Lymphomatoid Papulosis

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Sources:
43Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 12DrugBank
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Compounds related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 16)
idCompoundScoreTop Affiliating Genes
1larc439.7CXCR3, CCL17
2il 10439.7CXCR3, CCL17
3tarc439.7CCL17, CXCR3
4ccl343 2810.6CXCR3, CCL17
5ccl443 2810.6CCL17, CXCR3
6allergens439.6CCL17, CXCR3
7heparan sulfate43 2410.1GZMB, CXCR3
8tacrolimus43 49 1210.9CXCR3, CCL17, GZMB
9prednisolone43 28 1210.9GZMB, TIA1
10rantes438.9GZMB, CCL17, CXCR3
11dexamethasone43 49 28 1211.7GZMB, CCL17, CXCR3
12adp43 28 2410.7CXCR3, CCL17, ACVRL1
13nitric oxide43 24 1210.6GZMB, CCL17, CXCR3
14vegf438.6CXCR3, ACVRL1, GZMB
15[alcl]438.4GZMB, ACVRL1, CCL17, TIA1
16serine438.3GZMB, ACVRL1, CXCR3, TIA1

GO Terms for genes affiliated with Lymphomatoid Papulosis

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Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of endothelial cell proliferationGO:00019379.3ACVRL1, CXCR3
2angiogenesisGO:00015259.3ACVRL1, CXCR3
3chemotaxisGO:00069359.1CCL17, CXCR3
4apoptotic processGO:00069158.6GZMB, CXCR3, TIA1

Products for genes affiliated with Lymphomatoid Papulosis

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Sources for Lymphomatoid Papulosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet