LYP
MCID: LYM052
MIFTS: 50

Lymphomatoid Papulosis (LYP) malady

Skin, Blood, Cancer, Immune categories

Summaries for Lymphomatoid Papulosis

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards: Lymphomatoid Papulosis, also known as LYP, is related to anaplastic large cell lymphoma and mycosis fungoides. An important gene associated with Lymphomatoid Papulosis is ACVRL1 (activin A receptor type II-like 1), and among its related pathways are Regulation by c-FLIP and FasL/ CD95L signaling. The compounds cycloheximide and cxcl9 have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and bone marrow, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia:64 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Aliases & Classifications for Lymphomatoid Papulosis

Sources:
43NIH Rare Diseases, 45Novoseek, 49Orphanet, 61UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Skin, Blood, Immune


Characteristics (Orphanet epidemiological data):

49
lymphomatoid papulosis:
Age of onset: Adulthood


Aliases & Descriptions:

lymphomatoid papulosis 43 45 49 61
lyp 43


External Ids:

MESH via Orphanet36 D017731
ICD10 via Orphanet26 C86.6
SNOMED-CT via Orphanet58 31047003, 397353001
UMLS via Orphanet62 C0206182
ICD1025 L41.2

Related Diseases for Lymphomatoid Papulosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma31.3ALK, CCR4, CCL17, GZMB, TNFRSF8, NPM1
2mycosis fungoides31.2TNFRSF8, TRB, CD7, CLU, CXCR3, GZMB
3thymoma30.2TRB
4amyloidosis30.2CLU, B2M
5acute leukemia30.2CD7, TRB, NPM1
6arthritis30.2CCR3, GZMB, B2M, TRB, HBB, CLU
7b-cell lymphomas30.2JUNB, TIA1, CCL17, ALK, GZMB, TNFRSF8
8graves' disease30.0FAS, FASLG, TRB, CXCR3
9pityriasis lichenoides10.7
10follicular lymphoma10.6
11primary cutaneous anaplastic large cell lymphoma10.6
12pediatric lymphoma10.5
13hypereosinophilic syndrome10.5
14bone lymphoma10.3
15n syndrome10.3
16ichthyosis, acquired10.3
17colon lymphoma10.2
18molluscum contagiosum10.2
19proctitis10.2
20lethal midline granuloma10.2
21macroglobulinemia10.2
22tuberculum sellae meningioma10.2
23heart lymphoma10.2
24nevoid basal cell carcinoma syndrome10.2
25juvenile rheumatoid arthritis10.2
26retina lymphoma10.2
27pyoderma gangrenosum10.2
28breast lymphoma10.2
29basal cell carcinoma10.2
30anaplastic small cell lymphoma10.2
31nevo syndrome10.2
32cluster headache10.2
33hydroa vacciniforme10.2
34lymphomatoid granulomatosis10.2
35pityriasis lichenoides chronica10.2
36ulcerative proctitis10.2
37cytomegalovirus infection10.2
38headache10.2
39amyloidosis, renal10.2
40panniculitis10.0TIA1
41cervical intraepithelial neoplasia10.0GZMB
42thyroiditis10.0FASLG
43bronchiolitis obliterans10.0CXCR3
44polymyositis10.0GZMB
45human immunodeficiency virus infectious disease10.0FASLG
46pneumonia10.0CCL17
47neuroblastoma10.0ALK
48myositis10.0GZMB
49oral cancer10.0FASLG
50esophagitis10.0CCR3

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Clinical Features for Lymphomatoid Papulosis

Drugs & Therapeutics for Lymphomatoid Papulosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphomatoid Papulosis

Drug clinical trials:

Search ClinicalTrials for Lymphomatoid Papulosis

Search NIH Clinical Center for Lymphomatoid Papulosis

Search CenterWatch for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

Anatomical Context for Lymphomatoid Papulosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Lymphomatoid Papulosis:

33
Skin, Tongue, Bone marrow, Heart, Colon, Breast, Monocytes, T cells, B cells

Animal Models for Lymphomatoid Papulosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lymphomatoid Papulosis

Sources:
51PubMed
See all sources

Articles related to Lymphomatoid Papulosis:

(show top 50)    (show all 344)
idTitleAuthorsYear
1
CD30-Negative Lymphomatoid Papulosis Type D in an Elderly Man. (24394303)
2014
2
A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection. (22715829)
2012
3
Lymphomatoid papulosis: is a second lymphoma commoner among East Asians? (21790721)
2012
4
Bullous lymphomatoid papulosis. (21575041)
2011
5
Rapid cutaneous dissemination of persistently agminated lymphomatoid papulosis in a 9-year-old boy. (22106136)
2011
6
Acral lymphomatoid papulosis. (20159331)
2010
7
Lymphomatoid papulosis followed by anaplastic large cell lymphoma in a pediatric patient. (21165218)
2010
8
A case of indolent CD56-positive lymphomatoid papulosis. (21093657)
2010
9
Successful treatment of lymphomatoid papulosis with photodynamic therapy. (19397568)
2009
10
Lymphomatoid papulosis after allogenic stem cell transplantation. (19527993)
2009
11
Case of regional lymphomatoid papulosis confined to the periorbital areas. (19335692)
2009
12
Lymphomatoid papulosis with CD1a+ dendritic cell hyperplasia, mimicking Langerhans cell histiocytosis. (17576340)
2007
13
Therapeutic use of mistletoe for CD30+ cutaneous lymphoproliferative disorder/lymphomatoid papulosis. (17374000)
2007
14
Hodgkin's lymphoma with concurrent systemic amyloidosis, presenting as acute renal failure, following lymphomatoid papulosis. (16874698)
2006
15
Medium-dose UVA1 therapy of lymphomatoid papulosis. (15761440)
2005
16
Skin lesions of lymphomatoid papulosis with a white halo. (15987316)
2005
17
Co-existent primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. (14616830)
2003
18
Bexarotene is a new treatment option for lymphomatoid papulosis. (12592082)
2003
19
Reversal of hypereosinophilic syndrome and lymphomatoid papulosis with mepolizumab and imatinib. (14599646)
2003
20
Lymphomatoid papulosis with a natural killer-cell phenotype. (11531801)
2001
21
Successful treatment of a patient with lymphomatoid papulosis by methotrexate. (11510505)
2001
22
Recurrent pruritic papules in a 74-year-old man. Diagnosis: lymphomatoid papulosis (LyP). (11594865)
2001
23
Regional lymphomatoid papulosis: a report of four cases. (10606866)
1999
24
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
25
Lymphomatoid papulosis and FK 506. (9159004)
1997
26
Lymphomatoid papulosis and cutaneous CD30+ lymphoma. (8806956)
1996
27
Lymphomatoid papulosis followed by Ki-1 positive anaplastic large cell lymphoma: proliferation of a common T-cell clone. (8586753)
1995
28
Lymphomatoid papulosis: a clinical case. (7655118)
1995
29
Lymphomatoid papulosis associated with Ki-1-positive anaplastic large cell lymphoma. A report of two cases and a review of the literature. (7954268)
1994
30
Lymphomatoid papulosis: a follow-up study of 41 patients. (7986688)
1994
31
Lymphomatoid papulosis associated with acquired ichthyosis. (7909544)
1994
32
Lymphomatoid papulosis: case report of a patient managed with radiation therapy and review of the literature. (1524041)
1992
33
Lymphomatoid papulosis followed by large-cell lymphoma: immunophenotypical and genotypical analysis. (1645581)
1991
34
Analysis of beta, gamma, and delta T-cell receptor genes in lymphomatoid papulosis: cellular basis of two distinct histologic subsets. (1850775)
1991
35
Lymphomatoid papulosis. (1753408)
1991
36
Lymphomatoid papulosis, Ki-1+ lymphoma, and primary cutaneous Hodgkin's disease. (1657104)
1991
37
Lymphomatoid papulosis and progression to T cell lymphoma: an immunophenotypic and genotypic analysis. (2553788)
1989
38
Lymphomatoid papulosis and its relationship to "idiopathic" hypereosinophilic syndrome. (2964459)
1988
39
Lymphomatoid papulosis. A follow-up study of 30 patients. (2889756)
1987
40
Immunohistology of pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica. Evidence for their interrelationship with lymphomatoid papulosis. (2434538)
1987
41
Lymphomatoid papulosis expresses immunophenotypes associated with T cell lymphoma but not inflammation. (3489740)
1986
42
Clinical and histologic differentiation between lymphomatoid papulosis and pityriasis lichenoides. (4056116)
1985
43
Lymphomatoid papulosis: a follow-up study. (6203281)
1984
44
Transient lymphomatoid papulosis in mycosis fungoides. (6187163)
1982
45
Lymphomatoid papulosis. Macaulay's disease. (7270814)
1981
46
Lymphomatoid papulosis and primary cutaneous Hodgkin's disease. (7463421)
1981
47
Lymphomatoid papulosis. A model of immunoblastic reaction of the skin. (1032518)
1976
48
Lymphomatoid papulosis eventuating in mycosis fungoides. (4479691)
1974
49
DNA measurements in lymphomatoid papulosis: evidence for this new entity. (5793137)
1969
50
Lymphomatoid papulosis. A continuing self-healing eruption, clinically benign--histologically malignant. (5634442)
1968

Genetic Variations for Lymphomatoid Papulosis

Expression for genes affiliated with Lymphomatoid Papulosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphomatoid Papulosis

Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for genes affiliated with Lymphomatoid Papulosis

Sources:
54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems, 30KEGG, 52QIAGEN, 4Cell Signaling Technology, 56SinoBiological
See all sources

Pathways related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.0FAS, FASLG
210.0FAS, FASLG
3
Apoptosis and survival Caspase cascade
Hide members
9.8FASLG, FAS, GZMB
4
Hide members
9.8FASLG, FAS, GZMB
59.7HBB, FASLG, FAS
6
Hide members
9.5GZMB, IRF4, FAS, FASLG
7
Hide members
9.5GZMB, FAS, FASLG, B2M
8
Hide members
9.4CCR4, CCL17, CCR3, CXCR3
99.4CXCR3, CCR3, CCL17, CCR4
10
Hide members
9.3JUNB, IRF4, FASLG
11
Hide members
9.2FASLG, FAS, NPM1, PDGFRA
12
Hide members
9.2FASLG, FAS, GZMB, JUNB
139.1JUNB, GZMB, FASLG, B2M
149.0FASLG, FAS, PDGFRA, JUNB
15
Hide members
8.9GZMB, FASLG, B2M, TRB
168.8JUNB, GZMB, FAS, FASLG, B2M
17
Hide members
8.8TNFRSF8, NPM1, FAS, FASLG, B2M
18
Hide members
8.5CCR4, CCL17, CCR3, PDGFRA, TNFRSF8, CXCR3
19
Hide members
7.8ALK, CCR4, CCL17, CCR3, PDGFRA, TNFRSF8
20
Hide members
7.7JUNB, CCR4, CCL17, CCR3, PDGFRA, TNFRSF8
21
Hide members
7.7JUNB, CCR4, CCL17, CCR3, PDGFRA, TNFRSF8

Compounds for genes affiliated with Lymphomatoid Papulosis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7FASLG
2cxcl92910.3CCR3, CXCR3
3cxcl112910.3CXCR3, CCR3
4cxcl102910.3CCR3, CXCR3
5butyrate4510.3B2M, CCR3
6ccl112910.2CXCR3, CCR3
7ccl132910.2CCR3, CXCR3
8ccl52910.1CCR3, CXCR3
9concanamycin a45 6011.1GZMB, FAS, FASLG
10ccl72910.1CXCR3, CCR3
11larc4510.0CCL17, CCR4, CXCR3
12rantes4510.0GZMB, CXCR3, FAS, FASLG
13dutp4510.0FASLG, CLU, FAS
14(glc)44510.0FASLG, FAS
152-chlorodeoxyadenosine459.9B2M, FASLG, FAS
16tarc459.8CCR4, CXCR3, CCL17, CCR3
17ccl345 2910.8CCR4, CCR3, CXCR3, CCL17
18ccl445 2910.8CCL17, CCR4, CCR3, CXCR3
19sodium nitroprusside459.8CXCR3, FAS, B2M, FASLG
20tgf beta1459.7FASLG, FAS, PDGFRA, ACVRL1
21prednisolone45 29 1111.7CCR4, GZMB, TIA1, FAS
22tacrolimus45 50 1111.7FASLG, CXCR3, CCL17, GZMB
23camptothecin45 60 1111.6CLU, FAS, FASLG, NPM1
24agarose459.5FASLG, GZMB, NPM1, FAS, CLU
25heparin45 29 11 2412.5GZMB, FAS, FASLG, CLU, CXCR3, CCR3
26morphine45 50 29 1112.5FAS, CCR3, FASLG, JUNB
27tamoxifen45 50 29 1112.5CLU, HBB, JUNB, FASLG
28rapamycin459.3NPM1, FASLG, FAS, GZMB, PDGFRA
29serine459.2ALK, ACVRL1, CXCR3, CLU, HBB, B2M
30doxorubicin45 50 1111.1ALK, NPM1, FAS, FASLG, B2M, CLU
31aspartate459.0ALK, HBB, B2M, FASLG, NPM1, PDGFRA
32genistein45 29 60 2 11 2414.0FAS, FASLG, B2M, CCR3, JUNB
33vegf458.9FAS, CLU, PDGFRA, B2M, FASLG, CXCR3
34dexamethasone45 50 29 1111.9JUNB, FAS, CCL17, CCR3, GZMB, CLU
35calcitriol45 60 11 2411.9PDGFRA, JUNB, CLU, B2M
36actinomycin d458.8CLU, FAS, JUNB, CCR3, FASLG, NPM1
37alanine458.8ALK, CCR3, GZMB, NPM1, HBB, FASLG
38lactate458.7CLU, GZMB, NPM1, FAS, FASLG, B2M
39phosphatidylinositol458.6FAS, JUNB, FASLG, CXCR3, ALK, PDGFRA
40cysteine458.6CLU, HBB, B2M, FASLG, FAS, NPM1
41[alcl]458.5ALK, ACVRL1, TIA1, CCR4, CCL17, GZMB
42atp45 299.4JUNB, GZMB, TIA1, PDGFRA, NPM1, CLU
43thymidine45 249.4CCR3, PDGFRA, TNFRSF8, FASLG, B2M, HBB
44zinc45 249.2TNFRSF8, CCR4, FASLG, CLU, HBB, NPM1
45cyclosporin a45 29 609.9TRB, B2M, GZMB, CCL17, TNFRSF8, FAS
46oligonucleotide457.8JUNB, GZMB, ACVRL1, CLU, HBB, TRB
47retinoic acid45 248.6B2M, JUNB, CLU, CCR4, FASLG, CCR3
48paraffin456.9TRB, B2M, FAS, NPM1, TIA1, FASLG
49tyrosine456.0JUNB, ALK, FASLG, CCR3, GZMB, PDGFRA
50calcium45 50 11 249.0CCR4, JUNB, CCL17, CCR3, PDGFRA, NPM1

GO Terms for genes affiliated with Lymphomatoid Papulosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.6CCR3, PDGFRA, FASLG, CXCR3, ACVRL1, ALK
2external side of plasma membraneGO:0098978.4CXCR3, B2M, FASLG, FAS, PDGFRA, CCR4

Biological processes related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FAS, FASLG
2retina vasculature development in camera-type eyeGO:06129810.1PDGFRA, ACVRL1
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.1FASLG, FAS
4chemotaxisGO:0069359.6CXCR3, CCR3, CCL17, CCR4
5positive regulation of NF-kappaB transcription factor activityGO:0510929.6ALK, CLU, NPM1
6elevation of cytosolic calcium ion concentrationGO:0072049.5CXCR3, PDGFRA, CCR3, CCR4
7positive regulation of apoptotic processGO:0430659.5TNFRSF8, FAS, FASLG, CLU
8inflammatory responseGO:0069549.3CXCR3, CCR3, CCL17, CCR4
9apoptotic processGO:0069159.1TIA1, GZMB, FAS, FASLG, CXCR3
10signal transductionGO:0071658.7TNFRSF8, NPM1, FAS, FASLG, ACVRL1, ALK

Molecular functions related to Lymphomatoid Papulosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1C-C chemokine receptor activityGO:0164939.8CCR3, CCR4
2chemokine receptor activityGO:0049509.5CXCR3, CCR3, CCR4
3protein bindingGO:0055156.1IRF4, PDGFRA, GZMB, CCR3, TIA1, JUNB

Products for genes affiliated with Lymphomatoid Papulosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphomatoid Papulosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet