Lymphomatoid Papulosis malady

NIH Rare Diseases: Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). Lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system).³⁰

MalaCards: Lymphomatoid Papulosis, also known as LYP, is related to pityriasis lichenoides and hodgkin's lymphoma. An important gene associated with Lymphomatoid Papulosis is TNFRSF8 (tumor necrosis factor receptor superfamily, member 8), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Allograft rejection. The compounds larc and heparin have been mentioned in the context of this disorder. Affiliated tissues include skin and t cells, and related mouse phenotypes are respiratory system and liver/biliary system.

Wikipedia: Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid...⁴⁴ more...

lymphomatoid papulosis 30 32 43 lyp 30

Diseases related to lymphomatoid papulosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 210)

id	Related Disease	Score	Top Affiliating Genes
1	pityriasis lichenoides	31.1	CD7, CCR4
2	hodgkin's lymphoma	29.5	JUNB, GZMB, IRF4, CCR4, CCL17, ALK
3	non-hodgkin lymphoma	28.8	B2M, JUNB, GZMB, IRF4, FAS, ALK
4	cutaneous t cell lymphoma	28.4	GZMB, FAS, CCR4, CCL17, TRG@, TRB@
5	anaplastic large cell lymphoma	28.0	CLU, JUNB, GZMB, IRF4, FAS, CCR4
6	lymphopenia	27.7	B2M, FASLG, FAS
7	graves' disease	27.3	B2M, FASLG, FAS, CCR4, CCR3, TRB@
8	thymoma	26.9	B2M, JUNB, FAS, CCR3, TRG@, TRB@
9	composite lymphoma	13.4	GZMB, TNFRSF8, TIA1
10	subcutaneous panniculitis-like t-cell lymphoma	13.4	GZMB, TRG@
11	eosinophilic pneumonia	13.3	CCR4, CCL17, CXCR3
12	cutaneous lupus erythematosus	13.3	CCR4, CCL17, CXCR3
13	intermediate uveitis	13.3	CCR4, CXCR3
14	contact dermatitis	13.3	CCR4, CXCR3
15	paragonimiasis	13.3	CCL17, CXCR3
16	lumbar disc degeneration	13.3	FASLG, FAS
17	dyserythropoietic anemia with thrombocytopenia	13.3	GZMB, FAS, TIA1
18	allergic contact dermatitis of eyelid	13.2	GZMB, CCR4, CXCR3
19	bronchiolitis obliterans	13.2	GZMB, CCL17, TNFRSF8, CXCR3
20	hemophagocytic lymphohistiocytosis	13.1	GZMB, FAS, TIA1
21	autoimmune thyroiditis	13.1	FASLG, FAS, CXCR3
22	idiopathic pulmonary fibrosis	13.1	FASLG, CCR4, CCL17, CXCR3
23	cutaneous leishmaniasis	13.1	FASLG, FAS, TNFRSF8
24	keratoconjunctivitis	13.1	CCR4, CCL17, CXCR3
25	hepatitis	13.0	GZMB, FASLG, FAS
26	pulmonary sarcoidosis	13.0	CCR4, TRB@, CXCR3
27	myositis	13.0	CLU, GZMB, TIA1, CXCR3
28	t-cell large granular lymphocyte leukemia	13.0	GZMB, FASLG, TRB@
29	sezary's disease	13.0	CD7, CCR4, TRB@
30	lichen sclerosus	12.9	GZMB, FAS, TRG@, TIA1
31	polymyositis	12.9	CLU, GZMB, FASLG, FAS
32	wheat allergic reaction	12.9	GZMB, CCR4, CCL17, CCR3
33	reticulosarcoma	12.9	GZMB, ALK, TNFRSF8, TIA1, NPM1
34	posterior uveitis	12.9	FASLG, FAS, TRB@
35	intestine carcinoma in situ	12.9	FASLG, FAS
36	erythema multiforme	12.9	FAS, CCL17, CCR3, CXCR3
37	lichen planus	12.9	GZMB, FASLG, FAS, CXCR3
38	down syndrome	12.8	CD7, CCL17, TRB@
39	hemoglobinemia	12.8	B2M, HBB
40	panniculitis	12.8	GZMB, FAS, TRG@, TNFRSF8, TIA1
41	bullous pemphigoid	12.8	CCR4, CCL17, CCR3, TNFRSF8, CXCR3
42	silicosis	12.8	B2M, FASLG, FAS
43	atopic dermatitis	12.8	CCR4, CCL17, CCR3, TNFRSF8, CXCR3
44	plasmacytoma	12.8	B2M, IRF4, TNFRSF8
45	relapsing-remitting multiple sclerosis	12.8	FAS, TRB@, CXCR3
46	splenomegaly	12.7	FASLG, FAS, HBB
47	allergic rhinitis	12.7	CCR4, CCL17, CCR3, TNFRSF8, CXCR3
48	cerebral malaria	12.7	FASLG, FAS, CCR3, CXCR3
49	rhinitis	12.7	CCR4, CCL17, CCR3, TNFRSF8, CXCR3
50	malt lymphoma	12.7	IRF4, TRB@, CXCR3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to lymphomatoid papulosis:

²²

MGI Mouse Phenotypes related to lymphomatoid papulosis:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.3	CCR4, ACVRL1
2	liver/biliary system phenotype	MP:0005370	9.0	TRB@, ACVRL1, HBB, NPM1
3	other phenotype	MP:0005395	8.6	CLU, PDGFRA, HBB, CXCR3
4	renal/urinary system phenotype	MP:0005367	8.4	HBB, PDGFRA, JUNB, CLU
5	mortality/aging	MP:0010768	7.7	CXCR3, ACVRL1, PDGFRA, TRB@, GZMB, TIA1
6	digestive/alimentary phenotype	MP:0005381	7.2	ACVRL1, TRB@, B2M, FASLG, FAS, TRG@
7	tumorigenesis	MP:0002006	6.8	B2M, JUNB, GZMB, FASLG, FAS, CXCR3
8	cardiovascular system phenotype	MP:0005385	6.8	CLU, NPM1, CXCR3, B2M, JUNB, FASLG
9	integument phenotype	MP:0010771	6.6	B2M, NPM1, HBB, FAS, TRB@, TRG@
10	immune system phenotype	MP:0005387	6.5	JUNB, CLU, TIA1, HBB, CD7, TRB@
11	homeostasis/metabolism phenotype	MP:0005376	6.1	GZMB, B2M, JUNB, FASLG, FAS, CCR3
12	cellular phenotype	MP:0005384	5.5	IRF4, JUNB, NPM1, CXCR3, PDGFRA, TNFRSF8
13	hematopoietic system phenotype	MP:0005397	4.5	TRB@, TNFRSF8, PDGFRA, ACVRL1, HBB, TIA1

Articles related to lymphomatoid papulosis:

(show all 17)

id	Title	Authors	Year	Affiliating Genes
1	Resolution of CD8+ lymphomatoid papulosis after surgi cal excision of the type AB-thymoma. (19542925)	De Souza A.... Micallef I.N.	2009	CCR3
2	Lymphomatoid papulosis and associated lymphomas: a re trospective case series of 84 patients. (19196298)	Kunishige J.H.... Duvic M.	2009	B2M
3	MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (18410414)	Kempf W.... Pfaltz M.	2008	IRF4
4	Platelet-derived growth factor receptor-alpha-associated hypereosinophilic syndrome and lymphomatoid papulosis. (16965435)	McPherson T.... Klion A.D.	2006	PDGFRA
5	JunB expression is a common feature of CD30+ lymphomas and lymphomatoid papulosis. (15920551)	Rassidakis G.Z.... Medeiros L.J.	2005	ALK, JUNB
6	Single-cell analysis of CD30+ cells in lymphomatoid papulosis demonstrates a common clonal T-cell origin. (12091351)	Steinhoff M.... Stein H.	2002	TNFRSF8
7	Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligand. (11594583)	Kadin M.E.... Kempf W.	2001	TNFRSF8
8	Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins. (10672058)	Boulland M.L.... Gaulard P.	2000	GZMB, TNFRSF8, TIA1
9	Long-range amplification of genomic DNA detects the t(2;5)(p23;q35) in anaplastic large-cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis. (9209643)	Sarris A.H.... Pugh W.C.	1997	NPM1, HBB
10	Absence of anaplastic lymphoma kinase (ALK) and Epstein-Barr virus gene products in primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. (9415224)	Herbst H.... Kaudewitz P.	1997	ALK
11	Amplification of genomic DNA demonstrates the presence of the t(2;5) (p23;q35) in anaplastic large cell lymphoma, but not in other non-Hodgkin's lymphomas, Hodgkin's disease, or lymphomatoid papulosis. (8781434)	Sarris A.H.... Pugh W.C.	1996	ALK, TNFRSF8, NPM1
12	Primary anaplastic large-cell lymphoma of the skin. A case report suggesting that regressing atypical histiocytosis and lymphomatoid papulosis are subsets. (8294598)	Yashiro N.... Hamada T.	1994	TRB@
13	Molecular evidence for a clonal relationship between lymphomatoid papulosis and Ki-1 positive large cell anaplastic lymphoma. (8274457)	Volkenandt M.... Kadin M.E.	1993	TRG@
14	Ki-1 (CD30) expression in differentiation of lymphomatoid papulosis from arthropod bite reactions. (1344811)	Smoller B.R.... Warnke R.A.	1992	TNFRSF8
15	Lymphomatoid papulosis with antigen deletion and clonal rearrangement in a 4-year-old boy. (1692995)	Hellman J.... Strauchen J.A.	1990	TRB@
16	Immunohistochemical distinction of lymphomatoid papulosis and pityriasis lichenoides et varioliformis acuta. (1691596)	Varga F.J.... Kadin M.E.	1990	CD7
17	Hodgkin's disease followed by lymphomatoid papulosis. Immunophenotypic evidence for a close relationship between lymphomatoid papulo sis and Hodgkin's disease. (2370346)	Kaudewitz P.... Braun-Falco O.	1990	TNFRSF8

Genes related to lymphomatoid papulosis according to GeneCards:

(show all 21)

id	Symbol	Description	Score	GeneCards Section Context
1	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0	Publications
2	ACVRL1	activin A receptor type II-like 1	11.0
3	TIA1	TIA1 cytotoxic granule-associated RNA binding protein	11.0	Publications
4	CCR4	chemokine (C-C motif) receptor 4	11.0
5	CCL17	chemokine (C-C motif) ligand 17	11.0
6	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications
7	CXCR3	chemokine (C-X-C motif) receptor 3	11.0
8	CLU	clusterin	11.0
9	NPM1	nucleophosmin (nucleolar phosphoprotein B23, numatrin)	11.0	Publications
10	ALK	anaplastic lymphoma receptor tyrosine kinase	11.0	Publications
11	FASLG	Fas ligand (TNF superfamily, member 6)	11.0
12	FAS	Fas (TNF receptor superfamily, member 6)	11.0
13	TRG@	T cell receptor gamma locus	11.0	Publications
14	CD7	CD7 molecule	11.0	Publications
15	IRF4	interferon regulatory factor 4	11.0	Publications
16	JUNB	jun B proto-oncogene	11.0	Publications
17	CCR3	chemokine (C-C motif) receptor 3	11.0	Publications
18	B2M	beta-2-microglobulin	11.0	Publications
19	HBB	hemoglobin, beta	11.0	Publications
20	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
21	TRB@	T cell receptor beta locus	11.0	Publications

Pathways related to lymphomatoid papulosis according to GeneDecks:

(show all 18)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	GZMB, FAS, FASLG
2	Allograft rejection20	9.8	FAS, GZMB, FASLG
3	Graft-versus-host disease20	9.8	FASLG, FAS, GZMB
4	Type I diabetes mellitus20	9.7	GZMB, FASLG, FAS
5	Apoptosis38	9.7	FASLG, GZMB
6	Autoimmune thyroid disease20	9.6	GZMB, FASLG, FAS
7	Class A/1 (Rhodopsin-like receptors)38	9.5	CCR4, CCL17, CCR3, CXCR3
8	Lymphocyte Signaling3	9.5	B2M, FASLG, JUNB
9	African trypanosomiasis20	9.5	HBB, FASLG, FAS
10	Chemokine Signaling36	9.4	CCR4, CXCR3, CCL17, CCR3
11	Chemokine signaling pathway20	9.4	CCR3, CCR4, CCL17, CXCR3
12	STAT3 Pathway36	9.3	TNFRSF8, CXCR3, CCR3, CCL17, CCR4, ACVRL1
13	Akt Signaling36	8.5	CCL17, CCR3, CXCR3, CCR4, TNFRSF8, PDGFRA
14	Tec Kinases Signaling36	8.5	CXCR3, CCR4, PDGFRA, ACVRL1, TNFRSF8, CCR3
15	Antioxidant Action of Vitamin-C36	8.5	CXCR3, CCR4, CCL17, CCR3, TNFRSF8, PDGFRA
16	Molecular Mechanisms of Cancer36	8.4	TNFRSF8, CCR4, CCL17, ALK, PDGFRA, ACVRL1
17	Cytokine-cytokine receptor interaction20	8.1	FASLG, FAS, CCR4, CCL17, CCR3, TNFRSF8
18	p38 Signaling36	7.8	JUNB, CCR4, CCR3, ALK, TNFRSF8, PDGFRA

Compounds related to lymphomatoid papulosis according to GeneDecks:

(show top 50)    (show all 56)

id	Compound	Score	Top Affiliating Genes
1	larc32	10.2	CXCR3, CCL17, CCR4
2	heparin32 9 18 9	13.2	CCR3, CXCR3
3	(glc)432	10.1	FAS, FASLG
4	emetine32	10.1	NPM1, FASLG
5	atpo32	10.1	FAS, FASLG
6	concanamycin a42 32	11.0	GZMB, FASLG, FAS
7	morphine32 9 9	12.0	CCR3, JUNB
8	dutp32	9.9	FAS, CLU, FASLG
9	prednisolone32 9 9	11.9	CCR4, FAS, TIA1, GZMB
10	ivig32	9.8	FASLG, GZMB, FAS
11	tarc32	9.8	CCR4, CCL17, CCR3, CXCR3
12	ccl332	9.8	CCL17, CXCR3, CCR4, CCR3
13	ccl432	9.8	CCR4, CCL17, CXCR3, CCR3
14	tacrolimus32 34 9 9	12.8	CXCR3, GZMB, CCL17, FASLG
15	rapamycin32 42	10.7	PDGFRA, GZMB
16	camptothecin32 42 9 9	12.7	FASLG, NPM1, FAS, CLU
17	2-chlorodeoxyadenosine32	9.7	B2M, FASLG, FAS
18	ifn-alpha32	9.7	FASLG, FAS, CXCR3
19	vegf32	9.6	CLU, PDGFRA, ACVRL1
20	tamoxifen32 34 9 9	12.6	JUNB, FASLG, CLU, FAS
21	agarose32	9.6	CLU, NPM1, FAS, FASLG, GZMB
22	sodium nitroprusside32	9.5	FAS, FASLG, CXCR3, B2M
23	tgf beta132	9.2	PDGFRA, FAS, ACVRL1, FASLG
24	cysteine32	9.0	CLU, HBB, GZMB, FASLG, CCR3
25	rantes32	9.0	CCL17, CCR3, CXCR3, CCR4, FASLG, GZMB
26	doxorubicin32 34 9 9	12.0	CLU, B2M, FAS, ALK, NPM1, FASLG
27	estrogen32	9.0	CLU, HBB, PDGFRA, GZMB
28	[alcl]32	9.0	TIA1, NPM1, ACVRL1, TNFRSF8, ALK, CCL17
29	actinomycin d32	8.9	NPM1, CCR3, FASLG, JUNB, FAS, CLU
30	glyceraldehyde 3-phosphate32	8.9	CLU, B2M, HBB, NPM1
31	polyacrylamide32	8.8	HBB, TRB@, TRG@, NPM1
32	genistein32 9 18 9	11.7	CCR3, FASLG, FAS, B2M, JUNB
33	calcitriol32 42 9 18 9	12.6	JUNB, PDGFRA, B2M, CLU
34	dexamethasone32 42 34 9 9	12.5	CCR3, FASLG, CLU, JUNB, FAS, GZMB
35	butyrate32	8.5	CLU, B2M, FASLG, FAS, CCR3, HBB
36	zinc32 18	9.4	CCR4, NPM1, CLU, HBB, TNFRSF8, FASLG
37	cyclosporin a32 42	9.3	TNFRSF8, TRB@, CCL17, FAS, FASLG, GZMB
38	cycloheximide32	8.2	NPM1, HBB, JUNB, FAS, CLU, B2M
39	lactate32	8.2	NPM1, B2M, GZMB, FAS, HBB, FASLG
40	alanine32	8.2	HBB, CCR3, ALK, FASLG, GZMB, B2M
41	phosphatidylinositol32	8.1	PDGFRA, CXCR3, ALK, FASLG, FAS, JUNB
42	atp32	8.0	PDGFRA, HBB, TIA1, GZMB, JUNB, CLU
43	aspartate32	7.6	B2M, FASLG, FAS, NPM1, ALK, GZMB
44	oligonucleotide32	7.3	HBB, ACVRL1, PDGFRA, TRB@, FAS, FASLG
45	thymidine32 18	8.3	CLU, HBB, CXCR3, FAS, PDGFRA, TNFRSF8
46	serine32	7.3	TNFRSF8, ACVRL1, CXCR3, TIA1, HBB, ALK
47	retinoic acid32 42 18	9.2	JUNB, CCR4, CCR3, PDGFRA, FAS, NPM1
48	paraffin32	6.9	FASLG, FAS, CCR4, ALK, TNFRSF8, TRB@
49	tyrosine32	5.9	ALK, HBB, CLU, JUNB, GZMB, NPM1
50	calcium32 9 18 9	8.7	CLU, JUNB, B2M, GZMB, CCL17, FASLG

Cellular components related to lymphomatoid papulosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.6	CXCR3, CCR4, FAS, FASLG, B2M
2	integral to plasma membrane	GO:005887	8.0	CXCR3, ACVRL1, PDGFRA, ALK, CCR3, CCR4

Biological processes related to lymphomatoid papulosis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory cell apoptotic process	GO:006925	10.0	FASLG, FAS
2	chemokine-mediated signaling pathway	GO:070098	9.7	CXCR3, CCR3, CCR4
3	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.6	CLU, NPM1, TNFRSF8, ALK
4	activation of pro-apoptotic gene products	GO:008633	9.6	FASLG, GZMB, FAS
5	retina vasculature development in camera-type eye	GO:061298	9.5	PDGFRA, ACVRL1
6	chemotaxis	GO:006935	9.4	CCR4, CXCR3, CCR3, CCL17
7	positive regulation of apoptotic process	GO:043065	9.2	FAS, FASLG, TNFRSF8, CLU
8	elevation of cytosolic calcium ion concentration	GO:007204	8.9	CXCR3, PDGFRA, CCR4, CCR3

Molecular functions related to lymphomatoid papulosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	C-C chemokine receptor activity	GO:016493	9.8	CCR4, CCR3
2	tumor necrosis factor-activated receptor activity	GO:005031	9.7	FAS, TNFRSF8
3	chemokine receptor activity	GO:004950	9.5	CCR4, CCR3, CXCR3