MCID: LYM052
MIFTS: 41

Lymphomatoid Papulosis malady

Categories: Rare diseases, Skin diseases, Blood diseases, Immune diseases

Aliases & Classifications for Lymphomatoid Papulosis

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Sources:
29ICD10, 30ICD10 via Orphanet, 39MESH via Orphanet, 47NIH Rare Diseases, 49Novoseek, 53Orphanet, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 47 53 49 67
Lyp 47 53
 
X-Linked Lymphoproliferative Disorder 67

Characteristics:

Orphanet epidemiological data:

53
lymphomatoid papulosis:
Inheritance: Not yet documented; Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet53 ORPHA98842
MESH via Orphanet39 D017731
UMLS via Orphanet68 C0206182
ICD10 via Orphanet30 C86.6
ICD1029 L41.2

Summaries for Lymphomatoid Papulosis

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Wikipedia:70 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

MalaCards based summary: Lymphomatoid Papulosis, also known as lyp, is related to eosinophilia and lymphoma, and has symptoms including hepatomegaly An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin), and among its related pathways are IL-10 Pathway and Downstream signaling in naive CD8+ T cells. Affiliated tissues include t cells, skin and bone marrow, and related mouse phenotypes are neoplasm and skeleton.

Related Diseases for Lymphomatoid Papulosis

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Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1eosinophilia30.0GZMB, TIA1
2lymphoma10.8
3anaplastic large cell lymphoma10.5
4mycosis fungoides10.5
5pityriasis lichenoides10.4
6congenital sucrase-isomaltase deficiency with starch intolerance10.3ALK, NPM1
7cutaneous t cell lymphoma10.3
8male infertility10.2GZMB, TIA1
9subependymal nodular heterotopia10.2GZMB, TIA1
10primary cutaneous anaplastic large cell lymphoma10.2
11pseudotyphus of california10.2GZMB, TIA1
12clivus chordoma10.2GZMB, TIA1
13gray zone lymphoma10.2GZMB, TIA1
14pityriasis lichenoides et varioliformis acuta10.2
15breast fibroadenosis10.2GZMB, TIA1
16renal hypertension10.2GZMB, TIA1
17lumbosacral lipoma10.2GZMB, TIA1
18mixed cell type cancer10.2GZMB, TIA1
19lacrimal passage granuloma10.2GZMB, TIA1
20sialolithiasis10.1GZMB, TIA1
21histiocytosis10.1
22lymphopenia10.1
23leukemia10.1
24hypereosinophilic syndrome10.1
25tonsillar fossa cancer10.1FAS, GZMB
26benign adult familial myoclonic epilepsy10.0FAS, TYK2
27mixed extragonadal germ cell cancer10.0ALK, NPM1
28trigeminal nerve disease10.0FASLG, GZMB
29polycystic ovary syndrome9.9ALK, GZMB, TIA1
30multiple myeloma9.9
31chronic lymphocytic leukemia9.9
32pyoderma9.9
33hemolytic anemia9.9ALK, NPM1
34bolivian hemorrhagic fever9.9FASLG, GZMB
3512p12.1 microdeletion syndrome9.8FAS, FASLG
36hypodermyiasis9.8FASLG, GZMB
37pediatric systemic lupus erythematosus9.8FAS, FASLG
38rheumatoid arthritis9.8
39arthritis9.8
40b-cell lymphomas9.8
41crohn's disease9.8
42lymphomatoid granulomatosis9.8
43peripheral t-cell lymphoma9.8
44retinal vein occlusion9.8
45skin conditions9.8
46basal cell carcinoma9.8
47transitional cell carcinoma9.8
48proctitis9.8
49keratoacanthoma9.8
50thymoma9.8

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Symptoms for Lymphomatoid Papulosis

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UMLS symptoms related to Lymphomatoid Papulosis:


hepatomegaly

Drugs & Therapeutics for Lymphomatoid Papulosis

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Drugs for Lymphomatoid Papulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 26045
2Antibodies, MonoclonalPhase 23795
3AntibodiesPhase 26045

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell LymphomaCompletedNCT00099255Phase 2
2SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)Active, not recruitingNCT01352520Phase 2
3Tissue Repository: CTCL Collection ProtocolNot yet recruitingNCT02840747

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

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Anatomical Context for Lymphomatoid Papulosis

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MalaCards organs/tissues related to Lymphomatoid Papulosis:

35
T cells, Skin, Bone marrow, Breast, Bone, B cells, Tongue

Animal Models for Lymphomatoid Papulosis or affiliated genes

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MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1ALK, FAS, FASLG, NPM1
2MP:00053908.5ALK, FAS, FASLG, TIA1, TYK2

Publications for Lymphomatoid Papulosis

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Articles related to Lymphomatoid Papulosis:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. (26960644)
2016
2
Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. (27461449)
2016
3
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review. (27138554)
2016
4
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature. (26763888)
2016
5
Lymphomatoid papulosis and fingolimod-A new connection? (26993118)
2016
6
Lymphomatoid papulosis in a young adult of African descent. (27051732)
2015
7
Recommendations for treatment of lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group. (25998985)
2015
8
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. (24668491)
2014
9
Tattoos and coincidental skin conditions: the example of lymphomatoid papulosis. (24841722)
2014
10
Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. (25242096)
2014
11
A Unique Case of Concurrent Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma and Lymphomatoid Papulosis in the Same Biopsy. (25382820)
2014
12
Regional lymphomatoid papulosis successfully controlled by interferon I+-2b and nitrogen mustard solution. (23981641)
2013
13
Ulcerated nodules on the oral mucosa and fingers: lymphomatoid papulosis, type A. (23165794)
2013
14
A rare case of ulcerative proctitis associated with type B lymphomatoid papulosis and superimposed human cytomegalovirus infection. (22715829)
2012
15
In search of prognostic indicators for lymphomatoid papulosis: a retrospective study of 123 patients. (21982062)
2012
16
Persistent agmination of lymphomatoid papulosis: a new case with immunohistopathologically confirmed mycosis fungoides component. (21839314)
2011
17
Spectrum of CD30+ lymphoid proliferations in the eyelid lymphomatoid papulosis, cutaneous anaplastic large cell lymphoma, and anaplastic large cell lymphoma. (19969358)
2010
18
Acral lymphomatoid papulosis. (20159331)
2010
19
Regional lymphomatoid papulosis in a child--treatment with a UVB phototherapy handpiece. (20482240)
2010
20
A variant of lymphomatoid papulosis simulating primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. Description of 9 cases. (20661014)
2010
21
Dermoscopy of lymphomatoid papulosis. (19687447)
2009
22
Clinical, histopathologic, and immunophenotypic features of lymphomatoid papulosis with CD8 predominance in 14 pediatric patients. (19577330)
2009
23
Lymphomatoid papulosis while on efalizumab. (19700027)
2009
24
MUM1 expression in cutaneous CD30+ lymphoproliferative disorders: a valuable tool for the distinction between lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphoma. (18410414)
2008
25
Nevoid basal cell carcinoma syndrome associated with lymphomatoid papulosis. (12835561)
2003
26
Retinal vein occlusion in lymphomatoid papulosis. (12510725)
2002
27
Lymphomatoid papulosis with a natural killer-cell phenotype. (11531801)
2001
28
Progression of lymphomatoid papulosis to systemic lymphoma is associated with escape from growth inhibition by transforming growth factor-beta and CD30 ligand. (11594583)
2001
29
Lymphomatoid papulosis and human herpesviruses--A PCR-based evaluation for the presence of human herpesvirus 6, 7 and 8 related herpesviruses. (11168749)
2001
30
Keratoacanthomas and lymphomatoid papulosis. (9700388)
1998
31
Lymphomatoid papulosis and progression to T-cell immunoblastic lymphoma. (9643341)
1998
32
Lymphomatoid papulosis and FK 506. (9159004)
1997
33
Is it lymphoma or lymphomatoid papulosis? (9146539)
1997
34
Spectrum of CD30 lymphoproliferative diseases from lymphomatoid papulosis to anaplastic large cell lymphoma. (8970838)
1996
35
Cytogenetic findings in regressing skin lesions of lymphomatoid papulosis. (7697626)
1995
36
Hydroa vacciniforme-like lymphomatoid papulosis in a Japanese child: a new subset. (7829745)
1995
37
Symmetrical lymphomatoid papulosis masquerading as pyoderma chancriformis of the eyelids. (7742293)
1995
38
Lymphomatoid papulosis: a T-cell dyscrasia with a propensity to transform into malignant lymphoma. (7810940)
1995
39
Lymphomatoid papulosis. (8113450)
1994
40
Lethal midline granuloma (peripheral T-cell lymphoma) after lymphomatoid papulosis. (1322784)
1992
41
Clonal composition of T cells in lymphomatoid papulosis. (3544850)
1987
42
Clonal analysis of T cells in lymphomatoid papulosis. (3492673)
1987
43
Acyclovir in lymphomatoid papulosis and mycosis fungoides. (3723701)
1986
44
DNA analysis by flow cytometry in lymphomatoid papulosis. (6641008)
1983
45
Lymphomatoid papulosis. Case reports and literature review. (6824356)
1983
46
A case of lymphomatoid papulosis and systemic lymphoma. (7459273)
1981
47
Lymphomatoid papulosis and other pseudomalignancies of the skin. (576506)
1977
48
Cutaneous T cell lymphomas: mycosis fungoides, SAczary syndrome and lymphomatoid papulosis--Part I. (308870)
1977
49
Lymphomatoid papulosis. (931420)
1977
50
Lymphomatoid papulosis eventuating in mycosis fungoides. (4479691)
1974

Variations for Lymphomatoid Papulosis

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Expression for genes affiliated with Lymphomatoid Papulosis

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Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for genes affiliated with Lymphomatoid Papulosis

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Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 15)
idSuper pathwaysScoreTop Affiliating Genes
19.5TIA1, TYK2
2
Show member pathways
9.3FASLG, GZMB
39.2ALK, NPM1, TYK2
49.1FAS, FASLG
59.1FAS, FASLG
6
Show member pathways
8.9FASLG, GZMB, TYK2
7
Show member pathways
8.8FAS, FASLG, NPM1
8
Show member pathways
8.5FAS, FASLG, GZMB
9
Show member pathways
8.5FAS, FASLG, GZMB
10
Show member pathways
8.5FAS, FASLG, GZMB
11
Show member pathways
8.5FAS, FASLG, GZMB
12
Show member pathways
8.5FAS, FASLG, GZMB
13
Show member pathways
8.5FAS, FASLG, GZMB
148.1FAS, FASLG, GZMB, TYK2
158.0FAS, FASLG, GZMB, TIA1

GO Terms for genes affiliated with Lymphomatoid Papulosis

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Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00069259.9FAS, FASLG
2necroptotic signaling pathwayGO:00975279.8FAS, FASLG
3response to growth factorGO:00708489.7FAS, FASLG
4activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:00972969.7FAS, FASLG
5regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.7FAS, FASLG
6extrinsic apoptotic signaling pathwayGO:00971919.7FAS, FASLG
7negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.6FAS, FASLG
8activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.5FAS, FASLG
9extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.5FAS, FASLG
10apoptotic signaling pathwayGO:00971909.3FAS, FASLG
11signal transductionGO:00071658.3ALK, FAS, FASLG, NPM1
12apoptotic processGO:00069158.1FAS, FASLG, GZMB, TIA1

Sources for Lymphomatoid Papulosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet