MCID: LYM052
MIFTS: 45

Lymphomatoid Papulosis

Categories: Rare diseases, Skin diseases, Immune diseases, Blood diseases

Aliases & Classifications for Lymphomatoid Papulosis

MalaCards integrated aliases for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 49 55 51 69
Lyp 49 55

Characteristics:

Orphanet epidemiological data:

55
lymphomatoid papulosis
Inheritance: Not yet documented; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 55 ORPHA98842
MESH via Orphanet 42 D017731
UMLS via Orphanet 70 C0206182
ICD10 via Orphanet 33 C86.6
ICD10 32 L41.2
UMLS 69 C0206182

Summaries for Lymphomatoid Papulosis

NIH Rare Diseases : 49 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). Lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). Last updated: 6/19/2012

MalaCards based summary : Lymphomatoid Papulosis, also known as lyp, is related to lymphoma and anaplastic large cell lymphoma. An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin 1), and among its related pathways/superpathways are Development HGF signaling pathway and Kaposi's sarcoma-associated herpesvirus infection. The drugs Lenalidomide and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 72 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 lymphoma 30.9 ALK NPM1 TIA1
2 anaplastic large cell lymphoma 30.9 ALK GZMB NPM1
3 cutaneous t cell lymphoma 30.1 GZMB TIA1
4 lymphomatoid granulomatosis 30.1 GZMB TIA1
5 peripheral t-cell lymphoma 29.7 ALK GZMB TIA1
6 primary cutaneous anaplastic large cell lymphoma 29.3 ALK GZMB NPM1 TIA1 TYK2
7 lymphoproliferative syndrome, x-linked, 1 11.4
8 mycosis fungoides 10.6
9 pityriasis lichenoides 10.5
10 autoimmune lymphoproliferative syndrome, type v 10.4
11 pityriasis lichenoides et varioliformis acuta 10.3
12 alk-positive anaplastic large cell lymphoma 10.2 ALK NPM1
13 hypereosinophilic syndrome 10.2
14 leukemia 10.2
15 histiocytosis 10.2
16 orbit lymphoma 10.2 GZMB TIA1
17 lichen sclerosus et atrophicus 10.2 GZMB TIA1
18 viral esophagitis 10.2 GZMB TIA1
19 subcutaneous panniculitis-like t-cell lymphoma 10.2 GZMB TIA1
20 natural killer cell leukemia 10.2 GZMB TIA1
21 composite lymphoma 10.2 GZMB TIA1
22 hepatosplenic t-cell lymphoma 10.2 GZMB TIA1
23 giardiasis 10.1 GZMB TIA1
24 infiltrating lipoma 10.1 GZMB TIA1
25 necrotizing sialometaplasia 10.1 GZMB TIA1
26 leukemia, chronic lymphocytic 2 10.1
27 leukemia, chronic lymphocytic 10.1
28 leukemia, b-cell, chronic 10.1
29 inflammatory myofibroblastic tumor 10.1 ALK NPM1
30 multiple sclerosis 10.0
31 ichthyosis, acquired 10.0
32 pyoderma 10.0
33 myeloma, multiple 10.0
34 ichthyosis 10.0
35 breast medullary carcinoma 10.0 FASLG GZMB
36 lymphoma, hodgkin, classic 9.9 ALK GZMB TIA1
37 t-cell large granular lymphocyte leukemia 9.9 FASLG GZMB
38 lymphatic system cancer 9.9 ALK NPM1 TIA1
39 erythema multiforme 9.9 FASLG GZMB
40 transitional cell carcinoma 9.9
41 amyloidosis 9.9
42 arthritis 9.9
43 proctitis 9.9
44 follicular mucinosis 9.9
45 b-cell lymphomas 9.9
46 keratoacanthoma 9.9
47 crohn's disease 9.9
48 thymoma 9.9
49 cluster headache 9.9
50 blood group, i system 9.9

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to Lymphomatoid Papulosis

Symptoms & Phenotypes for Lymphomatoid Papulosis

GenomeRNAi Phenotypes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 ALK FAS FASLG NPM1
2 skeleton MP:0005390 9.02 ALK FAS FASLG TIA1 TYK2

Drugs & Therapeutics for Lymphomatoid Papulosis

Drugs for Lymphomatoid Papulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 2 191732-72-6 216326
2 Antibodies, Monoclonal Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2
5 Angiogenesis Inhibitors Phase 2
6 Angiogenesis Modulating Agents Phase 2
7 Anti-Bacterial Agents Phase 2
8 Anti-Infective Agents Phase 2
9 Immunosuppressive Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma Completed NCT00099255 Phase 2 SGN-30
2 SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP) Active, not recruiting NCT01352520 Phase 2 SGN-35
3 Brentuximab Vedotin and Lenalidomide in Treating Patients With Stage IB-IVB Relapsed or Refractory T-Cell Lymphoma Not yet recruiting NCT03409432 Phase 2 Brentuximab Vedotin;Lenalidomide
4 Tissue Repository: CTCL Collection Protocol Recruiting NCT02840747

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

Anatomical Context for Lymphomatoid Papulosis

MalaCards organs/tissues related to Lymphomatoid Papulosis:

38
Skin, T Cells, Bone Marrow, Breast, Bone, B Cells, Tongue

Publications for Lymphomatoid Papulosis

Articles related to Lymphomatoid Papulosis:

(show top 50) (show all 405)
# Title Authors Year
1
First-line treatment in lymphomatoid papulosis: a retrospective multicentre study. ( 28994134 )
2018
2
Unilesional locally recurrent lymphomatoid papulosis with variable histological presentation. ( 28562138 )
2018
3
Successful control of phototherapy-resistant lymphomatoid papulosis with oral bexarotene. ( 28971510 )
2018
4
Type D (CD8+) lymphomatoid papulosis in a patient with classic (CD4+) mycosis fungoides. ( 29378678 )
2018
5
Lymphomatoid papulosis - making sense of the alphabet soup: a proposal to simplify terminology. ( 28252259 )
2017
6
A Severe Case of Lymphomatoid Papulosis Type E Successfully Treated with Interferon-Alfa 2a. ( 28540091 )
2017
7
Brentuximab Vedotin for Patients With Refractory Lymphomatoid Papulosis: An Analysis of Phase 2 Results. ( 28980004 )
2017
8
Associated Hematolymphoid Malignancies in Patients With Lymphomatoid Papulosis: A Canadian Retrospective Study. ( 28614957 )
2017
9
Dermoscopy of different stages of lymphomatoid papulosis. ( 29171911 )
2017
10
Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene. ( 28374041 )
2017
11
An unusual case of lymphomatoid papulosis type E with extensive necrosis. ( 29067932 )
2017
12
Lymphomatoid papulosis associated with chronic lymphocytic leukemia/small lymphocytic lymphoma: 3 cases. ( 28569995 )
2017
13
Oral Lymphomatoid papulosis type C: A diagnostic pitfall, often confused with T-cell lymphoma. ( 29146059 )
2017
14
A Case of Lymphomatoid Papulosis Type E With an Unusual Exacerbated Clinical Course. ( 28937425 )
2017
15
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall. ( 26711583 )
2016
16
Follicular Lymphomatoid Papulosis: An Eosinophilic-Rich Follicular Subtype Masquerading as Folliculitis Clinically and Histologically. ( 26730698 )
2016
17
A child with mastocytosis and lymphomatoid papulosis. ( 27190619 )
2016
18
Lymphomatoid papulosis type D in a fingolimod-treated multiple sclerosis patient. ( 27053634 )
2016
19
Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. ( 27461449 )
2016
20
Human T-cell leukemia virus type 1-positive lymphomatoid papulosis. ( 26771231 )
2016
21
Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis. ( 26668250 )
2016
22
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature. ( 26763888 )
2016
23
Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. ( 26960644 )
2016
24
Regional lymphomatoid papulosis of the breast restricted to an area of prior radiotherapy. ( 27274553 )
2016
25
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review. ( 27138554 )
2016
26
Lymphomatoid papulosis and fingolimod-A new connection? ( 26993118 )
2016
27
Lymphomatoid papulosis associated with multiple myeloma. ( 27230953 )
2016
28
Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal. ( 28009441 )
2016
29
Lymphomatoid Papulosis in a 2-Year-Old Girl With Markedly Elevated Antinuclear Antibodies. ( 28006986 )
2016
30
Angioinvasive lymphomatoid papulosis (typeA E): a first Japanese case. ( 27267092 )
2016
31
Lymphomatoid papulosis: Treatment response and associated lymphomas in a study of 180 patients. ( 26518172 )
2015
32
New variant lymphomatoid papulosis type E preceding and coexisting with mycosis fungoides - a case report and review of the literature. ( 26272365 )
2015
33
Results of a Phase II Trial of Brentuximab Vedotin for CD30+ Cutaneous T-Cell Lymphoma and Lymphomatoid Papulosis. ( 26261247 )
2015
34
Lymphomatoid papulosis with pseudocarcinomatous hyperplasia in a seven-year-old girl: a case report. ( 26531106 )
2015
35
Lymphomatoid papulosis in a young adult of African descent. ( 27051732 )
2015
36
Shared clonality in distinctive lesions of lymphomatoid papulosis and mycosis fungoides occurring in the same patients suggests a common origin. ( 25666664 )
2015
37
Lymphomatoid papulosis associated with follicular B-cell lymphoma in lymph nodes. ( 26282183 )
2015
38
Commentary about papular mycosis fungoides, lymphomatoid papulosis, and lymphomatoid pityriasis lichenoides: More similarities than differences. ( 26566599 )
2015
39
Recommendations for treatment of lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group. ( 25998985 )
2015
40
Lymphomatoid papulosis: A cutaneous lymphoproliferative disorder in a patient on fingolimod for multiple sclerosis. ( 26219664 )
2015
41
The efficacy of methotrexate for lymphomatoid papulosis. ( 25981010 )
2015
42
Localized lymphomatoid papulosis. ( 25556677 )
2015
43
Self-healing Eyelid Nodule: A Quiz. Diagnosis: Lymphomatoid papulosis (LyP), type A. ( 25366062 )
2015
44
Atypical cutaneous I^I' T cell proliferation with morphologic features of lymphoma but with clinical features and course of PLEVA or lymphomatoid papulosis. ( 26263922 )
2015
45
Comparison of CD163+ Macrophages and CD206+ Cells in Lesional Skin of CD30+ Lymphoproliferative Disorders of Lymphomatoid Papulosis and Primary Cutaneous Anaplastic Large-cell Lymphoma. ( 25403560 )
2014
46
CD30-Negative Lymphomatoid Papulosis Type D in an Elderly Man. ( 24394303 )
2014
47
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. ( 24668491 )
2014
48
Lymphomatoid papulosis type C of the eyelid in a young girl: a case report and review of literature. ( 24911471 )
2014
49
Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expanding the spectrum of CD30-positive lymphoproliferative disorders. ( 24805854 )
2014
50
A Unique Case of Concurrent Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma and Lymphomatoid Papulosis in the Same Biopsy. ( 25382820 )
2014

Variations for Lymphomatoid Papulosis

Expression for Lymphomatoid Papulosis

Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for Lymphomatoid Papulosis

Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.36 FAS FASLG NPM1
2
Show member pathways
12.22 FAS FASLG TYK2
3
Show member pathways
12.15 FAS FASLG GZMB
4
Show member pathways
12.11 FAS FASLG GZMB
5 11.97 FAS FASLG GZMB TYK2
6
Show member pathways
11.84 FAS FASLG GZMB
7
Show member pathways
11.79 FAS FASLG TYK2
8 11.66 ALK NPM1 TYK2
9 11.52 FAS FASLG GZMB TIA1
10
Show member pathways
11.49 FAS FASLG
11
Show member pathways
11.49 FASLG GZMB TYK2
12 11.43 FAS FASLG
13
Show member pathways
11.33 FASLG GZMB
14 11.24 FAS FASLG
15 11.15 FAS FASLG
16 11 FAS FASLG
17 10.98 TIA1 TYK2
18
Show member pathways
10.36 FAS FASLG GZMB

GO Terms for Lymphomatoid Papulosis

Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.56 FAS FASLG GZMB TIA1
2 regulation of cell proliferation GO:0042127 9.5 ALK FAS TYK2
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.46 FAS FASLG
4 apoptotic signaling pathway GO:0097190 9.43 FAS FASLG
5 extrinsic apoptotic signaling pathway GO:0097191 9.4 FAS FASLG
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.37 FAS FASLG
7 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.16 FAS FASLG
8 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 8.96 FAS FASLG
9 necroptotic signaling pathway GO:0097527 8.62 FAS FASLG

Sources for Lymphomatoid Papulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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