LYP
MCID: LYM052
MIFTS: 41

Lymphomatoid Papulosis (LYP) malady

Categories: Rare diseases, Skin diseases, Blood diseases, Immune diseases

Aliases & Classifications for Lymphomatoid Papulosis

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Sources:
30ICD10, 31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 48 54 50 68
 
Lyp 48 54

Characteristics:

Orphanet epidemiological data:

54
lymphomatoid papulosis:
Inheritance: Not yet documented; Age of onset: All ages; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet54 ORPHA98842
MESH via Orphanet40 D017731
UMLS via Orphanet69 C0206182
ICD10 via Orphanet31 C86.6
ICD1030 L41.2

Summaries for Lymphomatoid Papulosis

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NIH Rare Diseases:48 Lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards based summary: Lymphomatoid Papulosis, also known as LYP, is related to skin conditions and lymphoma. An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin), and among its related pathways are IL-10 Pathway and Downstream signaling in naive CD8+ T cells. Affiliated tissues include skin, t cells and bone marrow, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and neoplasm.

Wikipedia:71 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

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Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1skin conditions29.4FAS, FASLG
2lymphoma10.7
3anaplastic large cell lymphoma10.5
4mycosis fungoides10.5
5pityriasis lichenoides10.4
6cutaneous t cell lymphoma10.3
7primary cutaneous anaplastic large cell lymphoma10.2
8pityriasis lichenoides et varioliformis acuta10.2
9complication after organ transplantation10.2ALK, NPM1
10malignant glioma10.1GZMB, TIA1
11alström syndrome10.1GZMB, TIA1
12tibial adamantinoma10.1GZMB, TIA1
13superior limbic keratoconjunctivitis10.1GZMB, TIA1
14collagen type iii glomerulopathy10.1GZMB, TIA1
15histiocytosis10.1
16fibrosclerosis of breast10.1GZMB, TIA1
17lymphopenia10.1
18uterine ligament endometrioid adenocarcinoma10.1GZMB, TIA1
19linear lichen planus10.1GZMB, TIA1
20cerebral lipidosis10.1GZMB, TIA1
21childhood immature teratoma of ovary10.1GZMB, TIA1
22leukemia10.1
23hypereosinophilic syndrome10.1
24plasmodium ovale malaria10.1GZMB, TIA1
25non-amyloid monoclonal immunoglobulin deposition disease10.1FAS, TYK2
26t-cell prolymphocytic leukemia10.0FAS, TYK2
27polyomavirus allograft nephropathy10.0FAS, TYK2
28histiocytic and dendritic cell cancer10.0FASLG, GZMB
29post-transplant lymphoproliferative disease10.0ALK, GZMB, TIA1
30estrogen-receptor negative breast cancer10.0ALK, NPM1, TIA1
31adenylosuccinase lyase deficiency10.0FASLG, GZMB
32venezuelan hemorrhagic fever10.0FASLG, GZMB
33midline interhemispheric variant of holoprosencephaly9.9FAS, FASLG
34multiple myeloma9.9
35chronic lymphocytic leukemia9.9
36ichthyosis9.9
37pyoderma9.9
38anauxetic dysplasia9.9FAS, FASLG
39acute myeloid leukemia with recurrent genetic anomaly9.9FASLG, GZMB
40hereditary ataxia9.9FAS, GZMB, TYK2
41trabecular follicular adenocarcinoma9.9FAS, FASLG
42pseudo-meigs syndrome9.9FAS, FASLG
43breast adenomyoepithelioma9.8FAS, FASLG
44periodontosis9.8FASLG, GZMB
45malignant teratoma9.8FASLG, GZMB, TIA1
46lip cancer9.8ALK, GZMB, NPM1, TIA1
47aortic arch interruption9.8ALK, GZMB, NPM1, TIA1
48hyperaldosteronism, familial, type ii9.8FASLG, GZMB, TIA1
49pituitary carcinoma9.8FAS, FASLG
50psoriasis susceptibility 19.8FAS, FASLG, GZMB

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to lymphomatoid papulosis

Symptoms & Phenotypes for Lymphomatoid Papulosis

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GenomeRNAi Phenotypes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-18.0FAS, FASLG, GZMB, TIA1

MGI Mouse Phenotypes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1ALK, FAS, FASLG, NPM1
2MP:00053908.5ALK, FAS, FASLG, TIA1, TYK2

Drugs & Therapeutics for Lymphomatoid Papulosis

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Drugs for Lymphomatoid Papulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ImmunoglobulinsPhase 26394
2Antibodies, MonoclonalPhase 24039
3AntibodiesPhase 26394

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell LymphomaCompletedNCT00099255Phase 2
2SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP)Active, not recruitingNCT01352520Phase 2
3Tissue Repository: CTCL Collection ProtocolRecruitingNCT02840747

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

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Anatomical Context for Lymphomatoid Papulosis

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MalaCards organs/tissues related to Lymphomatoid Papulosis:

36
Skin, T cells, Bone marrow, Breast, Bone, B cells, Tongue

Publications for Lymphomatoid Papulosis

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Articles related to Lymphomatoid Papulosis:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Lymphomatoid papulosis type D in a fingolimod-treated multiple sclerosis patient. (27053634)
2016
2
Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. (27461449)
2016
3
Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis. (26668250)
2016
4
Follicular Lymphomatoid Papulosis: An Eosinophilic-Rich Follicular Subtype Masquerading as Folliculitis Clinically and Histologically. (26730698)
2016
5
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall. (26711583)
2016
6
A child with mastocytosis and lymphomatoid papulosis. (27190619)
2016
7
Lymphomatoid Papulosis in a 2-Year-Old Girl With Markedly Elevated Antinuclear Antibodies. (28006986)
2016
8
Human T-cell leukemia virus type 1-positive lymphomatoid papulosis. (26771231)
2016
9
Lymphomatoid papulosis and fingolimod-A new connection? (26993118)
2016
10
Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. (26960644)
2016
11
Regional lymphomatoid papulosis of the breast restricted to an area of prior radiotherapy. (27274553)
2016
12
Lymphomatoid papulosis associated with multiple myeloma. (27230953)
2016
13
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature. (26763888)
2016
14
Angioinvasive lymphomatoid papulosis (typeA E): a first Japanese case. (27267092)
2016
15
Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal. (28009441)
2016
16
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review. (27138554)
2016
17
Lymphomatoid papulosis with pseudocarcinomatous hyperplasia in a seven-year-old girl: a case report. (26531106)
2015
18
Atypical cutaneous I^I' T cell proliferation with morphologic features of lymphoma but with clinical features and course of PLEVA or lymphomatoid papulosis. (26263922)
2015
19
Lymphomatoid papulosis: Treatment response and associated lymphomas in a study of 180 patients. (26518172)
2015
20
Commentary about papular mycosis fungoides, lymphomatoid papulosis, and lymphomatoid pityriasis lichenoides: More similarities than differences. (26566599)
2015
21
The efficacy of methotrexate for lymphomatoid papulosis. (25981010)
2015
22
Localized lymphomatoid papulosis. (25556677)
2015
23
Lymphomatoid papulosis in a young adult of African descent. (27051732)
2015
24
Results of a Phase II Trial of Brentuximab Vedotin for CD30+ Cutaneous T-Cell Lymphoma and Lymphomatoid Papulosis. (26261247)
2015
25
Lymphomatoid papulosis associated with follicular B-cell lymphoma in lymph nodes. (26282183)
2015
26
New variant lymphomatoid papulosis type E preceding and coexisting with mycosis fungoides - a case report and review of the literature. (26272365)
2015
27
Lymphomatoid papulosis: A cutaneous lymphoproliferative disorder in a patient on fingolimod for multiple sclerosis. (26219664)
2015
28
Recommendations for treatment of lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group. (25998985)
2015
29
Self-healing Eyelid Nodule: A Quiz. Diagnosis: Lymphomatoid papulosis (LyP), type A. (25366062)
2015
30
Shared clonality in distinctive lesions of lymphomatoid papulosis and mycosis fungoides occurring in the same patients suggests a common origin. (25666664)
2015
31
CD30-positive lymphoproliferative disorder in a red tattoo: regional lymphomatoid papulosis type C or pseudolymphoma? (24689991)
2014
32
Unusual CD8 positive lymphomatoid papulosis in childhood. (25419749)
2014
33
I^I' T cell-rich variants of pityriasis lichenoides and lymphomatoid papulosis: benign cutaneous disorders to be distinguished from aggressive cutaneous I^I' T cell lymphomas. (25143223)
2014
34
Recurrent course and CD30 expression of atypical T lymphocytes distinguish lymphomatoid papulosis from primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. (24549273)
2014
35
Regional lymphomatoid papulosis in association with pseudoepitheliomatous hyperplasia: 13A years follow-up. (24841636)
2014
36
Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expanding the spectrum of CD30-positive lymphoproliferative disorders. (24805854)
2014
37
Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. (25242096)
2014
38
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. (24668491)
2014
39
A Unique Case of Concurrent Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma and Lymphomatoid Papulosis in the Same Biopsy. (25382820)
2014
40
The importance of histopathology findings in lymphomatoid papulosis. (25611293)
2014
41
Lymphomatoid papulosis and recurrent transitional cell carcinoma of the bladder: a paraneoplastic association. (24746306)
2014
42
Exacerbation of lymphomatoid papulosis during rituximab therapy. (23190403)
2014
43
Tattoos and coincidental skin conditions: the example of lymphomatoid papulosis. (24841722)
2014
44
Lymphomatoid papulosis type C of the eyelid in a young girl: a case report and review of literature. (24911471)
2014
45
Lymphomatoid papulosis in children: a series of 25 cases. (24749749)
2014
46
Lymphomatoid papulosis with 6p25.3 rearrangement: a further case of the newly described variant. (24804939)
2014
47
Lymphomatoid papulosis misdiagnosed as pityriasis lichenoides et varioliformis acuta: Two case reports and a literature review. (25371758)
2014
48
Comparison of CD163+ Macrophages and CD206+ Cells in Lesional Skin of CD30+ Lymphoproliferative Disorders of Lymphomatoid Papulosis and Primary Cutaneous Anaplastic Large-cell Lymphoma. (25403560)
2014
49
CD30-Negative Lymphomatoid Papulosis Type D in an Elderly Man. (24394303)
2014
50
Lymphomatoid Papulosis Type D or an Aggressive Epidermotropic CD8 Cytotoxic T-cell Lymphoma? (24217891)
2013

Variations for Lymphomatoid Papulosis

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Expression for genes affiliated with Lymphomatoid Papulosis

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Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for genes affiliated with Lymphomatoid Papulosis

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Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathwaysScoreTop Affiliating Genes
19.5TIA1, TYK2
2
Show member pathways
9.3FASLG, GZMB
39.2ALK, NPM1, TYK2
49.1FAS, FASLG
59.1FAS, FASLG
69.1FAS, FASLG
79.1FAS, FASLG
8
Show member pathways
8.9FASLG, GZMB, TYK2
9
Show member pathways
8.5FAS, FASLG, GZMB
10
Show member pathways
8.5FAS, FASLG, GZMB
11
Show member pathways
8.5FAS, FASLG, GZMB
12
Show member pathways
8.5FAS, FASLG, GZMB
138.1FAS, FASLG, GZMB, TYK2
148.0FAS, FASLG, GZMB, TIA1

GO Terms for genes affiliated with Lymphomatoid Papulosis

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Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.8FAS, FASLG
2activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwayGO:00972969.8FAS, FASLG
3apoptotic signaling pathwayGO:00971909.8FAS, FASLG
4extrinsic apoptotic signaling pathwayGO:00971919.8FAS, FASLG
5extrinsic apoptotic signaling pathway via death domain receptorsGO:00086259.7FAS, FASLG
6inflammatory cell apoptotic processGO:00069259.7FAS, FASLG
7necroptotic signaling pathwayGO:00975279.7FAS, FASLG
8negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.7FAS, FASLG
9regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020419.1FAS, FASLG
10regulation of cell proliferationGO:00421279.1ALK, FAS, TYK2
11apoptotic processGO:00069158.6FAS, FASLG, GZMB, TIA1

Sources for Lymphomatoid Papulosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet