LYP
MCID: LYM052
MIFTS: 41

Lymphomatoid Papulosis (LYP) malady

Categories: Rare diseases, Skin diseases, Blood diseases, Immune diseases

Aliases & Classifications for Lymphomatoid Papulosis

Aliases & Descriptions for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 50 56 52 69
Lyp 50 56

Characteristics:

Orphanet epidemiological data:

56
lymphomatoid papulosis
Inheritance: Not yet documented; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA98842
MESH via Orphanet 43 D017731
UMLS via Orphanet 70 C0206182
ICD10 via Orphanet 34 C86.6
ICD10 33 L41.2

Summaries for Lymphomatoid Papulosis

NIH Rare Diseases : 50 lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards based summary : Lymphomatoid Papulosis, also known as lyp, is related to skin conditions and lymphoma. An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin), and among its related pathways/superpathways are Immune response Role of DAP12 receptors in NK cells and DREAM Repression and Dynorphin Expression. The drugs Antibodies and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and neoplasm

Wikipedia : 71 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
id Related Disease Score Top Affiliating Genes
1 skin conditions 29.4 FAS FASLG
2 lymphoma 10.7
3 anaplastic large cell lymphoma 10.5
4 mycosis fungoides 10.5
5 pityriasis lichenoides 10.4
6 cutaneous t cell lymphoma 10.3
7 primary cutaneous anaplastic large cell lymphoma 10.2
8 pityriasis lichenoides et varioliformis acuta 10.2
9 complication after organ transplantation 10.2 ALK NPM1
10 malignant glioma 10.1 GZMB TIA1
11 alström syndrome 10.1 GZMB TIA1
12 tibial adamantinoma 10.1 GZMB TIA1
13 superior limbic keratoconjunctivitis 10.1 GZMB TIA1
14 collagen type iii glomerulopathy 10.1 GZMB TIA1
15 histiocytosis 10.1
16 fibrosclerosis of breast 10.1 GZMB TIA1
17 lymphopenia 10.1
18 uterine ligament endometrioid adenocarcinoma 10.1 GZMB TIA1
19 linear lichen planus 10.1 GZMB TIA1
20 cerebral lipidosis 10.1 GZMB TIA1
21 childhood immature teratoma of ovary 10.1 GZMB TIA1
22 hypereosinophilic syndrome 10.1
23 leukemia 10.1
24 plasmodium ovale malaria 10.1 GZMB TIA1
25 non-amyloid monoclonal immunoglobulin deposition disease 10.1 FAS TYK2
26 t-cell prolymphocytic leukemia 10.0 FAS TYK2
27 polyomavirus allograft nephropathy 10.0 FAS TYK2
28 histiocytic and dendritic cell cancer 10.0 FASLG GZMB
29 post-transplant lymphoproliferative disease 10.0 ALK GZMB TIA1
30 estrogen-receptor negative breast cancer 10.0 ALK NPM1 TIA1
31 adenylosuccinase lyase deficiency 10.0 FASLG GZMB
32 venezuelan hemorrhagic fever 10.0 FASLG GZMB
33 midline interhemispheric variant of holoprosencephaly 9.9 FAS FASLG
34 multiple myeloma 9.9
35 ichthyosis 9.9
36 chronic lymphocytic leukemia 9.9
37 pyoderma 9.9
38 anauxetic dysplasia 9.9 FAS FASLG
39 acute myeloid leukemia with recurrent genetic anomaly 9.9 FASLG GZMB
40 hereditary ataxia 9.9 FAS GZMB TYK2
41 trabecular follicular adenocarcinoma 9.9 FAS FASLG
42 pseudo-meigs syndrome 9.9 FAS FASLG
43 breast adenomyoepithelioma 9.8 FAS FASLG
44 periodontosis 9.8 FASLG GZMB
45 malignant teratoma 9.8 FASLG GZMB TIA1
46 lip cancer 9.8 ALK GZMB NPM1 TIA1
47 aortic arch interruption 9.8 ALK GZMB NPM1 TIA1
48 hyperaldosteronism, familial, type ii 9.8 FASLG GZMB TIA1
49 pituitary carcinoma 9.8 FAS FASLG
50 psoriasis susceptibility 1 9.8 FAS FASLG GZMB

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to Lymphomatoid Papulosis

Symptoms & Phenotypes for Lymphomatoid Papulosis

GenomeRNAi Phenotypes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 TIA1 FAS GZMB
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 TIA1 FAS FASLG GZMB

MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 ALK FAS FASLG NPM1
2 skeleton MP:0005390 9.02 FAS FASLG TIA1 TYK2 ALK

Drugs & Therapeutics for Lymphomatoid Papulosis

Drugs for Lymphomatoid Papulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 2
2 Antibodies, Monoclonal Phase 2
3 Immunoglobulins Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma Completed NCT00099255 Phase 2
2 SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP) Active, not recruiting NCT01352520 Phase 2
3 Tissue Repository: CTCL Collection Protocol Recruiting NCT02840747

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

Anatomical Context for Lymphomatoid Papulosis

MalaCards organs/tissues related to Lymphomatoid Papulosis:

39
Skin, T Cells, Bone, Bone Marrow, Breast, B Cells, Tongue

Publications for Lymphomatoid Papulosis

Articles related to Lymphomatoid Papulosis:

(show top 50) (show all 391)
id Title Authors Year
1
Lymphomatoid papulosis type D in a fingolimod-treated multiple sclerosis patient. ( 27053634 )
2016
2
Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. ( 27461449 )
2016
3
Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis. ( 26668250 )
2016
4
Follicular Lymphomatoid Papulosis: An Eosinophilic-Rich Follicular Subtype Masquerading as Folliculitis Clinically and Histologically. ( 26730698 )
2016
5
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall. ( 26711583 )
2016
6
A child with mastocytosis and lymphomatoid papulosis. ( 27190619 )
2016
7
Lymphomatoid Papulosis in a 2-Year-Old Girl With Markedly Elevated Antinuclear Antibodies. ( 28006986 )
2016
8
Human T-cell leukemia virus type 1-positive lymphomatoid papulosis. ( 26771231 )
2016
9
Lymphomatoid papulosis and fingolimod-A new connection? ( 26993118 )
2016
10
Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. ( 26960644 )
2016
11
Regional lymphomatoid papulosis of the breast restricted to an area of prior radiotherapy. ( 27274553 )
2016
12
Lymphomatoid papulosis associated with multiple myeloma. ( 27230953 )
2016
13
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature. ( 26763888 )
2016
14
Angioinvasive lymphomatoid papulosis (typeA E): a first Japanese case. ( 27267092 )
2016
15
Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal. ( 28009441 )
2016
16
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review. ( 27138554 )
2016
17
Lymphomatoid papulosis with pseudocarcinomatous hyperplasia in a seven-year-old girl: a case report. ( 26531106 )
2015
18
Atypical cutaneous I^I' T cell proliferation with morphologic features of lymphoma but with clinical features and course of PLEVA or lymphomatoid papulosis. ( 26263922 )
2015
19
Lymphomatoid papulosis: Treatment response and associated lymphomas in a study of 180 patients. ( 26518172 )
2015
20
Commentary about papular mycosis fungoides, lymphomatoid papulosis, and lymphomatoid pityriasis lichenoides: More similarities than differences. ( 26566599 )
2015
21
The efficacy of methotrexate for lymphomatoid papulosis. ( 25981010 )
2015
22
Localized lymphomatoid papulosis. ( 25556677 )
2015
23
Lymphomatoid papulosis in a young adult of African descent. ( 27051732 )
2015
24
Results of a Phase II Trial of Brentuximab Vedotin for CD30+ Cutaneous T-Cell Lymphoma and Lymphomatoid Papulosis. ( 26261247 )
2015
25
Lymphomatoid papulosis associated with follicular B-cell lymphoma in lymph nodes. ( 26282183 )
2015
26
New variant lymphomatoid papulosis type E preceding and coexisting with mycosis fungoides - a case report and review of the literature. ( 26272365 )
2015
27
Lymphomatoid papulosis: A cutaneous lymphoproliferative disorder in a patient on fingolimod for multiple sclerosis. ( 26219664 )
2015
28
Recommendations for treatment of lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group. ( 25998985 )
2015
29
Self-healing Eyelid Nodule: A Quiz. Diagnosis: Lymphomatoid papulosis (LyP), type A. ( 25366062 )
2015
30
Shared clonality in distinctive lesions of lymphomatoid papulosis and mycosis fungoides occurring in the same patients suggests a common origin. ( 25666664 )
2015
31
CD30-positive lymphoproliferative disorder in a red tattoo: regional lymphomatoid papulosis type C or pseudolymphoma? ( 24689991 )
2014
32
Unusual CD8 positive lymphomatoid papulosis in childhood. ( 25419749 )
2014
33
I^I' T cell-rich variants of pityriasis lichenoides and lymphomatoid papulosis: benign cutaneous disorders to be distinguished from aggressive cutaneous I^I' T cell lymphomas. ( 25143223 )
2014
34
Recurrent course and CD30 expression of atypical T lymphocytes distinguish lymphomatoid papulosis from primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. ( 24549273 )
2014
35
Regional lymphomatoid papulosis in association with pseudoepitheliomatous hyperplasia: 13A years follow-up. ( 24841636 )
2014
36
Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expanding the spectrum of CD30-positive lymphoproliferative disorders. ( 24805854 )
2014
37
Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. ( 25242096 )
2014
38
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. ( 24668491 )
2014
39
A Unique Case of Concurrent Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma and Lymphomatoid Papulosis in the Same Biopsy. ( 25382820 )
2014
40
The importance of histopathology findings in lymphomatoid papulosis. ( 25611293 )
2014
41
Lymphomatoid papulosis and recurrent transitional cell carcinoma of the bladder: a paraneoplastic association. ( 24746306 )
2014
42
Exacerbation of lymphomatoid papulosis during rituximab therapy. ( 23190403 )
2014
43
Tattoos and coincidental skin conditions: the example of lymphomatoid papulosis. ( 24841722 )
2014
44
Lymphomatoid papulosis type C of the eyelid in a young girl: a case report and review of literature. ( 24911471 )
2014
45
Lymphomatoid papulosis in children: a series of 25 cases. ( 24749749 )
2014
46
Lymphomatoid papulosis with 6p25.3 rearrangement: a further case of the newly described variant. ( 24804939 )
2014
47
Lymphomatoid papulosis misdiagnosed as pityriasis lichenoides et varioliformis acuta: Two case reports and a literature review. ( 25371758 )
2014
48
Comparison of CD163+ Macrophages and CD206+ Cells in Lesional Skin of CD30+ Lymphoproliferative Disorders of Lymphomatoid Papulosis and Primary Cutaneous Anaplastic Large-cell Lymphoma. ( 25403560 )
2014
49
CD30-Negative Lymphomatoid Papulosis Type D in an Elderly Man. ( 24394303 )
2014
50
Lymphomatoid Papulosis Type D or an Aggressive Epidermotropic CD8 Cytotoxic T-cell Lymphoma? ( 24217891 )
2013

Variations for Lymphomatoid Papulosis

Expression for Lymphomatoid Papulosis

Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for Lymphomatoid Papulosis

Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.13 FAS FASLG GZMB
2
Show member pathways
12.09 FAS FASLG GZMB
3 11.95 FAS FASLG GZMB TYK2
4
Show member pathways
11.8 FAS FASLG GZMB
5 11.65 ALK NPM1 TYK2
6
Show member pathways
11.49 FASLG GZMB TYK2
7 11.4 FAS FASLG
8
Show member pathways
11.31 FASLG GZMB
9 11.22 FAS FASLG
10 11.19 FAS FASLG GZMB TIA1
11 11.14 FAS FASLG
12 10.98 FAS FASLG
13 10.95 TIA1 TYK2
14
Show member pathways
10.73 FAS FASLG GZMB

GO Terms for Lymphomatoid Papulosis

Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.62 FAS FASLG GZMB TIA1
2 regulation of cell proliferation GO:0042127 9.54 ALK FAS TYK2
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.49 FAS FASLG
4 apoptotic signaling pathway GO:0097190 9.48 FAS FASLG
5 extrinsic apoptotic signaling pathway GO:0097191 9.46 FAS FASLG
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.43 FAS FASLG
7 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.4 FAS FASLG
8 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.26 FAS FASLG
9 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.16 FAS FASLG
10 necroptotic signaling pathway GO:0097527 8.96 FAS FASLG
11 inflammatory cell apoptotic process GO:0006925 8.62 FAS FASLG

Sources for Lymphomatoid Papulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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