MCID: LYM052
MIFTS: 40

Lymphomatoid Papulosis

Categories: Rare diseases, Skin diseases, Blood diseases, Immune diseases

Aliases & Classifications for Lymphomatoid Papulosis

MalaCards integrated aliases for Lymphomatoid Papulosis:

Name: Lymphomatoid Papulosis 50 56 52 69
Lyp 50 56

Characteristics:

Orphanet epidemiological data:

56
lymphomatoid papulosis
Inheritance: Not yet documented; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA98842
MESH via Orphanet 43 D017731
UMLS via Orphanet 70 C0206182
ICD10 via Orphanet 34 C86.6
ICD10 33 L41.2

Summaries for Lymphomatoid Papulosis

NIH Rare Diseases : 50 lymphomatoid papulosis is a skin disorder that is characterized by crops of self healing skin lesions that look cancerous under the microscope but are actually benign (non-cancerous). lesions contain unusual cells that are similar to those found in some lymphomas (cancers of the lymphatic system). last updated: 6/19/2012

MalaCards based summary : Lymphomatoid Papulosis, also known as lyp, is related to lymphoma and anaplastic large cell lymphoma. An important gene associated with Lymphomatoid Papulosis is NPM1 (Nucleophosmin), and among its related pathways/superpathways are Immune response Role of DAP12 receptors in NK cells and NF-kappaB Signaling. The drugs Antibodies and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and neoplasm

Wikipedia : 72 Lymphomatoid papulosis (LyP) is a rare skin disorder. The overall prevalence rate of lymphomatoid... more...

Related Diseases for Lymphomatoid Papulosis

Diseases related to Lymphomatoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
id Related Disease Score Top Affiliating Genes
1 lymphoma 10.8
2 anaplastic large cell lymphoma 10.5
3 mycosis fungoides 10.5
4 congenital sucrase-isomaltase deficiency with minimal starch tolerance 10.4 ALK NPM1
5 pityriasis lichenoides 10.4
6 hypoglycemia 10.3 GZMB TIA1
7 male infertility 10.3 GZMB TIA1
8 clivus chondroid chordoma 10.3 GZMB TIA1
9 succinic acidemia lactic acidosis congenital 10.3 GZMB TIA1
10 rubella panencephalitis 10.3 GZMB TIA1
11 cutaneous t cell lymphoma 10.3
12 breast fibroadenosis 10.3 GZMB TIA1
13 pediatric lymphoma 10.3 GZMB TIA1
14 renal hypertension 10.3 GZMB TIA1
15 mucinous intrahepatic cholangiocarcinoma 10.2 GZMB TIA1
16 primary cutaneous anaplastic large cell lymphoma 10.2
17 plasmodium ovale malaria 10.2 GZMB TIA1
18 pityriasis lichenoides et varioliformis acuta 10.2
19 lymphopenia 10.1
20 leukemia 10.1
21 histiocytosis 10.1
22 hypereosinophilic syndrome 10.1
23 alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome 10.1 FAS TYK2
24 atypical lichen myxedematosus 10.1 FAS TYK2
25 mixed extragonadal germ cell cancer 10.0 ALK NPM1
26 aorta atresia 10.0 ALK GZMB NPM1
27 spinal cancer 10.0 FASLG GZMB
28 chronic lymphocytic leukemia 10.0
29 polycystic ovary syndrome 10.0 ALK GZMB TIA1
30 paramyloidosis 10.0 FASLG GZMB
31 pyridoxine-responsive sideroblastic anemia 9.9 GZMB TIA1
32 estrogen-receptor positive breast cancer 9.9 ALK NPM1 TIA1
33 multiple myeloma 9.9
34 ichthyosis 9.9
35 pyoderma 9.9
36 bolivian hemorrhagic fever 9.9 FASLG GZMB
37 acute monoblastic leukemia 9.9 FASLG GZMB
38 screw worm infectious disease 9.8 FASLG GZMB
39 juvenile sialidosis type 2 9.8 FAS FASLG
40 rheumatoid arthritis 9.8
41 arthritis 9.8
42 b-cell lymphomas 9.8
43 crohn's disease 9.8
44 lymphomatoid granulomatosis 9.8
45 peripheral t-cell lymphoma 9.8
46 retinal vein occlusion 9.8
47 skin conditions 9.8
48 mucositis 9.8
49 nephrotic syndrome 9.8
50 basal cell carcinoma 9.8

Graphical network of the top 20 diseases related to Lymphomatoid Papulosis:



Diseases related to Lymphomatoid Papulosis

Symptoms & Phenotypes for Lymphomatoid Papulosis

GenomeRNAi Phenotypes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 FAS GZMB TIA1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 FAS FASLG GZMB TIA1

MGI Mouse Phenotypes related to Lymphomatoid Papulosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.26 ALK FAS FASLG NPM1
2 skeleton MP:0005390 9.02 ALK FAS FASLG TIA1 TYK2

Drugs & Therapeutics for Lymphomatoid Papulosis

Drugs for Lymphomatoid Papulosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 2
2 Antibodies, Monoclonal Phase 2
3 Immunoglobulins Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Study of SGN-30 (Anti-CD30 mAb) in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma Completed NCT00099255 Phase 2 SGN-30
2 SGN-35 in CD30-positive Lymphoproliferative Disorders (ALCL), Mycosis Fungoides (MF), and Extensive Lymphomatoid Papulosis (LyP) Active, not recruiting NCT01352520 Phase 2 SGN-35
3 Tissue Repository: CTCL Collection Protocol Recruiting NCT02840747

Search NIH Clinical Center for Lymphomatoid Papulosis

Genetic Tests for Lymphomatoid Papulosis

Anatomical Context for Lymphomatoid Papulosis

MalaCards organs/tissues related to Lymphomatoid Papulosis:

39
Skin, T Cells, Bone Marrow, Breast, Bone, B Cells, Tongue

Publications for Lymphomatoid Papulosis

Articles related to Lymphomatoid Papulosis:

(show top 50) (show all 398)
id Title Authors Year
1
Unilesional locally recurrent lymphomatoid papulosis with variable histological presentation. ( 28562138 )
2018
2
Associated Hematolymphoid Malignancies in Patients With Lymphomatoid Papulosis: A Canadian Retrospective Study. ( 28614957 )
2017
3
Lymphomatoid papulosis associated with chronic lymphocytic leukemia/small lymphocytic lymphoma: 3 cases. ( 28569995 )
2017
4
Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene. ( 28374041 )
2017
5
A Case of Lymphomatoid Papulosis Type E With an Unusual Exacerbated Clinical Course. ( 28937425 )
2017
6
Lymphomatoid papulosis - making sense of the alphabet soup: a proposal to simplify terminology. ( 28252259 )
2017
7
A Severe Case of Lymphomatoid Papulosis Type E Successfully Treated with Interferon-Alfa 2a. ( 28540091 )
2017
8
Human T-cell leukemia virus type 1-positive lymphomatoid papulosis. ( 26771231 )
2016
9
Lymphomatoid Papulosis in a 2-Year-Old Girl With Markedly Elevated Antinuclear Antibodies. ( 28006986 )
2016
10
Lymphomatoid papulosis associated with multiple myeloma. ( 27230953 )
2016
11
Lymphomatoid Papulosis in Children and Adolescents: A Systematic Review. ( 27138554 )
2016
12
Lymphomatoid Papulosis Type D: Report of a Case in a Child and Review of the Literature. ( 26763888 )
2016
13
Pseudocarcinomatous Hyperplasia Hiding Lymphomatoid Papulosis: A "Low-Power View" Pitfall. ( 26711583 )
2016
14
Follicular lymphomatoid papulosis with follicular mucinosis: a clinicopathologic study of 3 cases with literature review and conceptual reappraisal. ( 28009441 )
2016
15
Lymphomatoid papulosis type D in a fingolimod-treated multiple sclerosis patient. ( 27053634 )
2016
16
Angioinvasive lymphomatoid papulosis (typeA E): a first Japanese case. ( 27267092 )
2016
17
Histopathological aspects and differential diagnosis of CD8 positive lymphomatoid papulosis. ( 27461449 )
2016
18
Type D lymphomatoid papulosis simulating aggressive epidermotropic cytotoxic lymphoma. ( 26960644 )
2016
19
Lymphomatoid papulosis and fingolimod-A new connection? ( 26993118 )
2016
20
Regional lymphomatoid papulosis of the breast restricted to an area of prior radiotherapy. ( 27274553 )
2016
21
Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis. ( 26668250 )
2016
22
Follicular Lymphomatoid Papulosis: An Eosinophilic-Rich Follicular Subtype Masquerading as Folliculitis Clinically and Histologically. ( 26730698 )
2016
23
A child with mastocytosis and lymphomatoid papulosis. ( 27190619 )
2016
24
Lymphomatoid papulosis with pseudocarcinomatous hyperplasia in a seven-year-old girl: a case report. ( 26531106 )
2015
25
Lymphomatoid papulosis in a young adult of African descent. ( 27051732 )
2015
26
Shared clonality in distinctive lesions of lymphomatoid papulosis and mycosis fungoides occurring in the same patients suggests a common origin. ( 25666664 )
2015
27
Self-healing Eyelid Nodule: A Quiz. Diagnosis: Lymphomatoid papulosis (LyP), type A. ( 25366062 )
2015
28
Lymphomatoid papulosis: Treatment response and associated lymphomas in a study of 180 patients. ( 26518172 )
2015
29
Results of a Phase II Trial of Brentuximab Vedotin for CD30+ Cutaneous T-Cell Lymphoma and Lymphomatoid Papulosis. ( 26261247 )
2015
30
Localized lymphomatoid papulosis. ( 25556677 )
2015
31
The efficacy of methotrexate for lymphomatoid papulosis. ( 25981010 )
2015
32
Lymphomatoid papulosis associated with follicular B-cell lymphoma in lymph nodes. ( 26282183 )
2015
33
Lymphomatoid papulosis: A cutaneous lymphoproliferative disorder in a patient on fingolimod for multiple sclerosis. ( 26219664 )
2015
34
Commentary about papular mycosis fungoides, lymphomatoid papulosis, and lymphomatoid pityriasis lichenoides: More similarities than differences. ( 26566599 )
2015
35
New variant lymphomatoid papulosis type E preceding and coexisting with mycosis fungoides - a case report and review of the literature. ( 26272365 )
2015
36
Recommendations for treatment of lymphomatoid papulosis with methotrexate: a report from the Dutch Cutaneous Lymphoma Group. ( 25998985 )
2015
37
Atypical cutaneous I^I' T cell proliferation with morphologic features of lymphoma but with clinical features and course of PLEVA or lymphomatoid papulosis. ( 26263922 )
2015
38
Unusual CD8 positive lymphomatoid papulosis in childhood. ( 25419749 )
2014
39
Recurrent course and CD30 expression of atypical T lymphocytes distinguish lymphomatoid papulosis from primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma. ( 24549273 )
2014
40
Exacerbation of lymphomatoid papulosis during rituximab therapy. ( 23190403 )
2014
41
Comparison of CD163+ Macrophages and CD206+ Cells in Lesional Skin of CD30+ Lymphoproliferative Disorders of Lymphomatoid Papulosis and Primary Cutaneous Anaplastic Large-cell Lymphoma. ( 25403560 )
2014
42
Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expanding the spectrum of CD30-positive lymphoproliferative disorders. ( 24805854 )
2014
43
Lymphomatoid papulosis misdiagnosed as pityriasis lichenoides et varioliformis acuta: Two case reports and a literature review. ( 25371758 )
2014
44
Lymphomatoid papulosis as a harbinger of chronic lymphocytic leukemia. ( 24668491 )
2014
45
CD30-Negative Lymphomatoid Papulosis Type D in an Elderly Man. ( 24394303 )
2014
46
I^I' T cell-rich variants of pityriasis lichenoides and lymphomatoid papulosis: benign cutaneous disorders to be distinguished from aggressive cutaneous I^I' T cell lymphomas. ( 25143223 )
2014
47
CD30-positive lymphoproliferative disorder in a red tattoo: regional lymphomatoid papulosis type C or pseudolymphoma? ( 24689991 )
2014
48
The importance of histopathology findings in lymphomatoid papulosis. ( 25611293 )
2014
49
Association of clinicopathological characteristics with secondary neoplastic lymphoproliferative disorders in patients with lymphomatoid papulosis. ( 25242096 )
2014
50
Lymphomatoid papulosis and recurrent transitional cell carcinoma of the bladder: a paraneoplastic association. ( 24746306 )
2014

Variations for Lymphomatoid Papulosis

Expression for Lymphomatoid Papulosis

Search GEO for disease gene expression data for Lymphomatoid Papulosis.

Pathways for Lymphomatoid Papulosis

Pathways related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.11 FAS FASLG GZMB
2 11.95 FAS FASLG GZMB TYK2
3
Show member pathways
11.8 FAS FASLG GZMB
4 11.65 ALK NPM1 TYK2
5 11.52 FAS FASLG GZMB TIA1
6
Show member pathways
11.49 FASLG GZMB TYK2
7
Show member pathways
11.47 FAS FASLG
8 11.39 FAS FASLG
9
Show member pathways
11.3 FASLG GZMB
10 11.2 FAS FASLG
11 11.12 FAS FASLG
12 10.98 FAS FASLG
13 10.95 TIA1 TYK2
14
Show member pathways
10.4 FAS FASLG GZMB

GO Terms for Lymphomatoid Papulosis

Biological processes related to Lymphomatoid Papulosis according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.62 FAS FASLG GZMB TIA1
2 regulation of cell proliferation GO:0042127 9.54 ALK FAS TYK2
3 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.49 FAS FASLG
4 apoptotic signaling pathway GO:0097190 9.48 FAS FASLG
5 extrinsic apoptotic signaling pathway GO:0097191 9.46 FAS FASLG
6 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.43 FAS FASLG
7 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.4 FAS FASLG
8 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.26 FAS FASLG
9 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.16 FAS FASLG
10 necroptotic signaling pathway GO:0097527 8.96 FAS FASLG
11 inflammatory cell apoptotic process GO:0006925 8.62 FAS FASLG

Sources for Lymphomatoid Papulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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