MCID: LYM027
MIFTS: 51

Lymphopenia malady

Summaries for Lymphopenia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Lymphocytopenia, or lymphopenia, is the condition of having an abnormally low level of lymphocytes in... more...

MalaCards: Lymphopenia, also known as lymphocytopenia, is related to systemic lupus erythematosus and arthritis. An important gene associated with Lymphopenia is RAG1 (recombination activating gene 1), and among its related pathways are Interleukin-7 signaling and Signaling by Interleukins. The compounds pge2 and ctla4-ig have been mentioned in the context of this disorder. Related mouse phenotypes are respiratory system and reproductive system.

Disease Ontology:8 A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood.

Aliases & Classifications for Lymphopenia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 27ICD9CM, 35MeSH, 40NCIt, 57SNOMED-CT
See all sources

Aliases & Descriptions:

lymphopenia 8 10 45 61
lymphocytopenia 8


External Ids:

Disease Ontology8 DOID:614
ICD9CM27 288.51
SNOMED-CT57 48813009
MeSH35 D008231
NCIt40 C26823

Related Diseases for Lymphopenia

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Lymphopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 248)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.7ADA, PTPN22, IL2RB, LCK, LBR, CIITA
2arthritis30.4FOXP3, CIITA, CD59, IL15, PTPN22, JAK3
3thrombocytopenia30.3IL7
4tuberculosis30.3ADA, PNP, IL7, CIITA, SELL, LBR
5mycosis fungoides30.1IL15, IL7, ADA, IL2RB
6thyroiditis30.1PTPN22, CIITA, FASLG
7thymoma30.1LBR, LCK, IL7
8leukopenia30.0LCK
9measles30.0LBR, CIITA
10autoimmune thyroiditis30.0FASLG, PTPN22, CIITA, CD59, PNP
11adenocarcinoma30.0CD59, FASLG, PNP, SELL, ADA
12burkitt's lymphoma29.8RAG1, IL7, LCK, ZAP70, FASLG, CD59
13hepatitis c29.8IL15, IL7, LCK, CIITA, IL7R, CD28
14adenosine deaminase deficiency29.8PNP, ADA
15asthma29.8ZAP70, IL7, SELL, LBR, JAK3, CIITA
16t-cell leukemia29.8IL2RB, CD28, ZAP70, LBR, FASLG, FOXP3
17omenn syndrome29.7ADA, RAG1
18atherosclerosis29.7SELL, CD59, CIITA, IL7
19pulmonary sarcoidosis29.7SELL, LBR, IL2RB
20acute graft versus host disease29.7IL15, FASLG, IL2RB
21colorectal cancer29.7IL15, CD59, LBR, FASLG, LCK
22alopecia areata29.7CIITA
23ulcerative colitis29.7CD59, CD28, IL15, IL7, SELL
24graft versus host disease29.7IL2RB, IL15, SELL, JAK3, FASLG, IL7
25purine nucleoside phosphorylase deficiency29.7ADA
26t-lymphocytopenia10.7
27leptospirosis10.1
28progressive multifocal leukoencephalopathy10.1
29n syndrome10.1
30agammaglobulinemia10.1
31lymphoma, diffuse large cell10.1
32hematopoietic stem cell transplantation10.1
33molluscum contagiosum10.0
34protein-losing enteropathy10.0
35aspergillosis10.0
36absent t lymphocytes10.0
37primary effusion lymphoma10.0
38mycetoma10.0
39crohn's disease10.0
40severe acute respiratory syndrome10.0
41swine influenza10.0
42thymic dysplasia10.0
43appendicitis10.0
44adult lymphoma10.0
45acute myocardial infarction10.0
46granulocytopenia10.0
47peripheral t-cell lymphoma10.0
48splenomegaly10.0
49alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity10.0
50sepsis10.0

Graphical network of the top 20 diseases related to Lymphopenia:



Diseases related to lymphopenia

Clinical Features for Lymphopenia

Drugs & Therapeutics for Lymphopenia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphopenia

Drug clinical trials:

Search ClinicalTrials for Lymphopenia

Search NIH Clinical Center for Lymphopenia

Search CenterWatch for Lymphopenia

Genetic Tests for Lymphopenia

Anatomical Context for Lymphopenia

Animal Models for Lymphopenia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Lymphopenia

Sources:
51PubMed
See all sources

Articles related to Lymphopenia:

(show top 50)    (show all 482)
idTitleAuthorsYear
1
The etiology of treatment-related lymphopenia in patients with malignant gliomas: modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells. (23362951)
2013
2
Primary immunodeficiencies appearing as combined lymphopenia, neutropenia, and monocytopenia. (24316408)
2013
3
Adult-onset manifestation of idiopathic T-cell lymphopenia due to a heterozygous RAG1 mutation. (23122631)
2013
4
Lymphopenia and treatment-related infectious complications in ANCA-associated vasculitis. (23220426)
2013
5
Lymphopenia following the completion of first-line therapy predicts early relapse in patients with diffuse large B cell lymphoma. (21811783)
2012
6
Progressive multifocal leukoencephalopathy in a patient with transitory lymphopenia. (22649215)
2012
7
TGF-I^ signaling to T cells inhibits autoimmunity during lymphopenia-driven proliferation. (22634866)
2012
8
Decreased interleukin 7 responsiveness of T lymphocytes in patients with idiopathic CD4 lymphopenia. (22454463)
2012
9
Depletion of radio-resistant regulatory T cells enhances antitumor immunity during recovery from lymphopenia. (22806892)
2012
10
Low CD40L levels and relative lymphopenia in narcoleptic patients. (21669245)
2011
11
Splenic lymphopenia in the endothelin receptor B-null mouse: implications for Hirschsprung associated enterocolitis. (21046116)
2011
12
Low peripheral lymphocyte count before focal radiotherapy plus concomitant temozolomide predicts severe lymphopenia during malignant glioma treatment. (20805645)
2010
13
New-onset lymphopenia assessed during routine follow-up is a risk factor for relapse postautologous peripheral blood hematopoietic stem cell transplantation in patients with diffuse large B-cell lymphoma. (19883776)
2010
14
No relapse of neuromyelitis optica during drug-induced B-lymphopenia with hypogammaglobulinemia. (21060099)
2010
15
Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia. (20220090)
2010
16
Rhodococcus equi pneumonia in a patient with fludarabine-treated chronic lymphocytic leukemia and CD4-lymphopenia. (20463575)
2010
17
Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. (19395456)
2009
18
Regulatory CD4+CD25+Foxp3+ T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells. (18490730)
2008
19
Immunological nonresponse to highly active antiretroviral therapy in HIV-infected subjects: is the bone marrow impairment causing CD4 lymphopenia? (18462176)
2008
20
What caused lymphopenia in SARS and how reliable is the lymphokine status in glucocorticoid-treated patients? (18448259)
2008
21
Genetically determined lymphopenia and autoimmune manifestations. (18403192)
2008
22
Primary calvarial cryptococcal osteomyelitis in a patient with idiopathic lymphopenia. (18560748)
2008
23
A phase II study of thalidomide and temozolomide in patients with brain metastases from malignant melanoma: lymphopenia correlates with response. (22275974)
2008
24
Lymphopenia associated with adjuvant anthracycline/ taxane regimens. (18757263)
2008
25
Severe combined immunodeficiency signalized by eosinophilia and lymphopenia in rotavirus infected infants. (18050045)
2007
26
CD25+Foxp3+ regulatory T cells facilitate CD4+ T cell clonal anergy induction during the recovery from lymphopenia. (16670295)
2006
27
FTY720 mediates apoptosis-independent lymphopenia in human renal allograft recipients: different effects on CD62L+ and CCR5+ T lymphocytes. (15167602)
2004
28
Lymphopenia and autoimmune diseases. (15225363)
2004
29
Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. (12515721)
2003
30
Functional evaluation of proliferative T cell responses in patients with severe T lymphopenia: characterization of optimal culture conditions and standardized activation signals for a simple whole blood assay. (14594509)
2003
31
Neonates support lymphopenia-induced proliferation. (12530982)
2003
32
Susceptibility to programmed cell death in T-lymphocytes from septic patients: a mechanism for lymphopenia and Th2 predominance. (12927795)
2003
33
On the role of MHC class II molecules in the survival and lymphopenia-induced proliferation of peripheral CD4+ T cells. (12719530)
2003
34
Increased lymphocyte death by neglect-apoptosis is associated with lymphopenia and autoantibodies in lupus patients presenting with neuropsychiatric manifestations. (12195452)
2002
35
Non-Hodgkin's lymphoma: an unusual complication of idiopathic CD4+ lymphopenia. (9798552)
1998
36
Mechanism for the T4 lymphopenia of AIDS. (7902577)
1993
37
The role of lymphocyte production and migration in the lymphopenia caused by 2-acetyl-4-tetrahydroxybutyl imidazole. (1521936)
1992
38
Lymphopenia in diverticulitis. (1678819)
1991
39
Lymphopenia in heavy drinkers--reversibility and relation to the duration of drinking episodes. (2248759)
1990
40
The gene for the T lymphocyte alloantigen, RT6, is not linked to either diabetes or lymphopenia and is not defective in the BB rat. (2583221)
1989
41
T4 lymphopenia in human tuberculosis. (3502379)
1987
42
Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration. (6339614)
1983
43
Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome. (6978807)
1982
44
Prognostic significance of lymphopenia in pulmonary sarcoidosis. (610096)
1977
45
Analysis of treatment in childhood leukaemia. III. Independence of lymphopenia induced by irradiation and by chemotherapy. (266949)
1977
46
Relationship of lymphocytotoxic antibodies to lymphopenia and parameters of disease activity in systemic lupus erythematosus. (1084929)
1976
47
Agammaglobulinemia, absent delayed sensitivity and lymphopenia without infections. A demonstration of immunologic unknowns. (4631943)
1973
48
Selective lymphopenia in man after intralymphatic injection of radioactive 131-I lipiodol. (4289356)
1967
49
PROGRESSIVE VACCINIA. CASE REPORT IN A NEWBORN INFANT WITH LYMPHOPENIA. (14334114)
1965
50
Prevention of hormona eosinopenia and lymphopenia by inhibition of clotting in blood; preliminary report. (14821549)
1951

Genetic Variations for Lymphopenia

Expression for genes affiliated with Lymphopenia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphopenia

Search GEO for disease gene expression data for Lymphopenia.

Pathways for genes affiliated with Lymphopenia

Sources:
54Reactome, 53R&D Systems, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN, 12EMD Millipore, 4Cell Signaling Technology
See all sources

Pathways related to Lymphopenia according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4IL2RG, IL7
2
Hide members
10.4IL7, IL2RG
310.4JAK3, IL7R
4
Hide members
10.4ADA, PNP
510.3CD59, IL7R, IL7
6
Cytokine production by Th17 cells in CF (Mouse model)
10.3IL2RG, JAK3, FOXP3
710.3IL2RG, JAK3, LCK
810.3IL2RG, IL2RB, FASLG
9
Hide members
10.3JAK3, CD28, IL2RG
10
Hide members
10.3IL2RG, IL2RB, IL7, IL7R
11
Hide members
10.3LCK, ZAP70, CD28
12
Immune response NFAT in immune response
Hide members
10.3CD28, ZAP70, LCK
13
Immune response ICOS pathway in T-helper cell
Hide members
10.3CD28, ZAP70, LCK
1410.3CD28, ZAP70, LCK
15
Hide members
10.3LCK, JAK3, IL2RB, IL2RG
16
Hide members
10.3LCK, JAK3, IL2RB, IL2RG
17
Immune response IL-2 activation and signaling pathway
Hide members
10.3LCK, JAK3, IL2RB, IL2RG
1810.3IL2RG, IL2RB, CD28, JAK3
19
Hide members
10.3LCK, FASLG, IL2RB, IL2RG
20
Hide members
10.2LCK, ZAP70, CD28, PTPN22
21
Hide members
10.2CD28, ZAP70, JAK3, LCK
22
Hide members
10.2FASLG, CIITA, CD28, IL15
23
Hide members
10.2LCK, FASLG, JAK3, ZAP70, IL2RG
24
Hide members
10.2FOXP3, FASLG, IL15, IL2RB, IL2RG
2510.2LCK, JAK3, IL15, IL2RB, IL2RG
26
Hide members
10.2LCK, ZAP70, CD28, IL2RB, IL2RG
2710.2LCK, ZAP70, CD28, IL2RB, IL2RG
2810.2FASLG, JAK3, IL7R, IL7, IL2RB, IL2RG
29
Hide members
10.2LCK, JAK3, IL7R, IL7, IL2RB, IL2RG
3010.2JAK3, IL15, IL7R, IL7, IL2RB, IL2RG
31
Hide members
10.2JAK3, IL15, IL7R, IL7, IL2RB, IL2RG
32
Hide members
10.2LCK, FOXP3, FASLG, JAK3, IL2RB, IL2RG
3310.1ADA, LCK, CIITA, ZAP70, IL7R, IL2RG
34
Hide members
10.1FASLG, JAK3, CD28, IL15, IL7R, IL2RG
35
Hide members
10.1LCK, JAK3, CIITA, IL7R, IL7, IL2RB
36
Hide members
10.1CD28, IL15, IL7R, IL7, IL2RB, IL2RG
37
Hide members
10.1FASLG, JAK3, CIITA, CD28, IL15, IL2RB
38
Hide members
10.0JAK3, ZAP70, CD28, IL15, IL7R, IL7
3910.0LCK, FOXP3, FASLG, CIITA, ZAP70, IL2RB
40
Hide members
10.0LCK, JAK3, ZAP70, CD28, IL15, IL7R
41
Hide members
9.9LCK, JAK3, CIITA, ZAP70, CD59, CD28

Compounds for genes affiliated with Lymphopenia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Lymphopenia according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1pge24510.9JAK3
2ctla4-ig4510.7IL7, IL2RB, CD28, IL15
3thiosemicarbazide4510.7LCK, IL2RB, ZAP70
4serine4510.6JAK3, IL2RB, CIITA, LCK
5fitc4510.6CD59, IL2RB, SELL, ZAP70
6enterotoxin4510.6LBR, CD28, CIITA, ZAP70
7leflunomide50 45 1112.6IL15, JAK3, LCK, IL2RB
8cycloheximide4510.6FASLG, LCK, JAK3, IL2RB, SELL
9c-d4t4510.6FASLG, IL7, IL15
10okt34510.6IL2RB, LBR, LCK, ZAP70, IL15, IL7
11fludarabine45 1111.6PNP, FASLG, ADA, ZAP70
12bromodeoxyuridine4510.5IL15, CIITA, FASLG, IL7, LBR
13herbimycin a45 6011.5CD28, IL7R, SELL, JAK3, LCK
14phenylalanine4510.5LBR, LCK, CD28, CIITA, ZAP70, JAK3
15cyclophosphamide45 50 1112.5IL15, IL7, IL2RB, ZAP70, FASLG
16heparin45 29 11 2413.5LCK, LBR, SELL, IL7, ZAP70, FASLG
17basiliximab45 1111.5IL7, IL2RB, IL15
18rantes4510.5FASLG, IL15, SELL, IL2RB, CIITA, IL7
19rituximab45 50 1112.5ZAP70, FASLG, IL15, CD59
20lactate4510.5PNP, FASLG, ZAP70, CD59, IL2RB, SELL
21histamine45 29 2412.5ADA, SELL, IL2RB, IL7, IL15, LBR
22glucose4510.5LBR, CD59, PNP, FASLG, LCK
23didanosine45 1111.5LBR, ADA, PNP
24tuberculin4510.5LBR, IL15, ADA
25phosphotyrosine4510.5IL7R, CD28, IL2RB, LCK, IL7, JAK3
26oxygen45 2411.5LCK, IL2RB, SELL, CD28, CD59, ZAP70
27tacrolimus45 50 1112.5IL7, IL15, IL2RB, FASLG, CD28
28thymidine45 2411.4CIITA, LBR, FASLG, IL15, IL7, IL2RB
29phosphatidylserine45 29 1112.4LCK, ZAP70, SELL, FASLG, IL2RB
30estrogen4510.4JAK3
31genistein45 29 60 2 11 2415.4CD28, JAK3, ZAP70, LBR, FASLG, LCK
32nitric oxide45 11 2412.4FASLG, FOXP3, LBR, JAK3, CIITA, IL15
33vegf4510.4IL2RB, IL15, IL7, FASLG, LCK, SELL
34purine45 2411.4LBR, ZAP70, ADA, PNP
35h2o24510.4ZAP70, FASLG, ADA, SELL, PNP, LBR
36ionomycin4510.4IL7, IL2RB, RAG1, SELL, IL7R, IL15
37rapamycin4510.4LCK, FOXP3, FASLG, LBR, CD28, IL15
38gtp45 2911.3PNP, IL2RB, ZAP70, CIITA, LCK, CD28
39alanine4510.3SELL, PNP, RAG1, IL2RB, ADA, CIITA
40cysteine4510.3RAG1, IL7, CD28, CIITA, FASLG, LCK
41lipid4510.3JAK3, IL15, CD28, IL7, LCK, LBR
4212-o-tetradecanoylphorbol 13-acetate4510.3IL7, RAG1, LBR, LCK, IL2RB
43phosphatidylinositol4510.3IL7R, IL7, IL2RB, LCK, CD28, FASLG
44dexamethasone45 50 29 1113.2LBR, CD28, LCK, FASLG, CIITA, ZAP70
45cuprophan4510.2IL2RB, LBR, SELL
46cyclosporin a45 29 6012.2LCK, CD28, ADA, IL2RG, IL2RB, IL7
47cyclic amp45 2411.2ADA, LCK, CD28, LBR, IL2RB
48calcium45 50 11 2413.2IL15, CD59, FASLG, CD28, IL2RB, ZAP70
49tyrosine4510.1CD59, LCK, LBR, JAK3, CIITA, ZAP70
50polysulfone4510.0IL2RB, SELL, FASLG

GO Terms for genes affiliated with Lymphopenia

Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.1SELL, IL2RG, IL2RB, IL15, CD28, FASLG
2cytoplasmic membrane-bounded vesicle lumenGO:06020510.1FASLG, ADA
3external side of plasma membraneGO:00989710.0ADA, SELL, IL2RG, IL2RB, IL7R, CD28

Biological processes related to Lymphopenia according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1interleukin-7-mediated signaling pathwayGO:03811110.7IL2RG, IL7R
2interleukin-2-mediated signaling pathwayGO:03811010.7IL2RB, IL2RG
3negative regulation of thymocyte apoptotic processGO:07024410.7ADA, RAG1, JAK3
4interleukin-4-mediated signaling pathwayGO:03577110.7IL2RG, JAK3
5T cell homeostasisGO:04302910.7RAG1, JAK3, FOXP3
6positive regulation of alpha-beta T cell differentiationGO:04663810.6ADA, PNP, ZAP70
7negative regulation of interleukin-10 productionGO:03269310.6JAK3, FOXP3
8T cell differentiationGO:03021710.6LCK, ZAP70, IL7R, PTPN22
9T cell activationGO:04211010.6ADA, ZAP70, FOXP3
10regulation of T cell differentiationGO:04558010.6RAG1, IL15
11T cell receptor signaling pathwayGO:05085210.6LCK, FOXP3, ZAP70, PTPN22
12positive regulation of T cell proliferationGO:04210210.6CD59, CD28, IL15, PNP
13peptidyl-tyrosine phosphorylationGO:01810810.6LCK, JAK3, ZAP70
14positive regulation of T cell receptor signaling pathwayGO:05086210.5ADA, LCK
15positive regulation of T cell differentiation in thymusGO:03308910.5IL7R, ADA
16positive regulation of alpha-beta T cell proliferationGO:04664110.5CD28, ZAP70
17negative thymic T cell selectionGO:04506010.5CD28, ZAP70
18negative regulation of T cell activationGO:05086810.4PTPN22, JAK3
19immune responseGO:00695510.4PNP, FASLG, CIITA, ZAP70, IL15, IL7R
20purine-containing compound salvageGO:04310110.4ADA, PNP
21lymph node developmentGO:04853510.4IL15, IL7R
22positive regulation of T cell differentiationGO:04558210.3ZAP70, IL7
23agingGO:00756810.0ADA, IL15, LCK

Molecular functions related to Lymphopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-7 receptor activityGO:00491710.5IL2RG, IL7R
2interleukin-2 bindingGO:01997610.4IL2RB, IL2RG
3protein tyrosine kinase activityGO:00471310.3ZAP70, JAK3, LCK
4interleukin-2 receptor activityGO:00491110.3IL2RB, IL2RG
5non-membrane spanning protein tyrosine kinase activityGO:00471510.0ZAP70, JAK3, LCK
6protein bindingGO:0055159.7ADA, LCK, FOXP3, FASLG, LBR, JAK3

Products for genes affiliated with Lymphopenia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Lymphopenia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet