MCID: LYM027
MIFTS: 51

Lymphopenia malady

Blood diseases, Immune diseases categories
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Summaries for Lymphopenia

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 Lymphocytopenia, or lymphopenia, is the condition of having an abnormally low level of lymphocytes in... more...

MalaCards: Lymphopenia, also known as lymphocytopenia, is related to arthritis and severe combined immunodeficiency. An important gene associated with Lymphopenia is RAG1 (recombination activating gene 1), and among its related pathways are Cytokine production by Th17 cells in CF and IL2 signaling events mediated by PI3K. The compounds caffeine and methylcellulose have been mentioned in the context of this disorder. Affiliated tissues include t cells, b cells and breast, and related mouse phenotypes are normal and respiratory system.

Disease Ontology:8 A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood.

Aliases & Classifications for Lymphopenia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Blood diseases, Immune diseases


Aliases & Descriptions:

lymphopenia 8 10 45 62
lymphocytopenia 8


External Ids:

Disease Ontology8 DOID:614
MeSH35 D008231
SNOMED-CT58 48813009
ICD9CM27 288.51
NCIt40 C26823

Related Diseases for Lymphopenia

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17GeneCards, 18GeneDecks
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Diseases related to Lymphopenia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 228)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.3CD59, FOXP3, PTPN22
2severe combined immunodeficiency30.2PNP, IL7, IL7R, IL2RG, RAG1
3rheumatoid arthritis30.1PNP, PTPN22, FOXP3, IL7, CD59
4breast cancer30.1CD59, IL7, PNP
5multiple sclerosis30.0PTPN22, FOXP3, IL7, IL7R, CD59
6melanoma30.0PNP, FOXP3, IL7, IL7R, IL2RG, CD59
7inflammatory bowel disease30.0PTPN22, FOXP3, IL7R, CD59
8non-hodgkin lymphoma30.0CD59, RAG1, IL7, PNP
9omenn syndrome29.9RAG1
10malaria29.9PNP
11connective tissue disease29.8FOXP3, PTPN22
12t-cell leukemia29.7RAG1, FOXP3, PNP
13leukemia29.7PNP, FOXP3, IL7, IL7R, IL2RG, RAG1
14autoimmune thyroiditis29.7PNP, PTPN22, CD59
15psoriasis29.6PNP, PTPN22, IL7, CD59
16t-lymphocytopenia11.0
17systemic lupus erythematosus10.5
18lupus erythematosus10.5
19neutropenia10.4
20influenza10.3
21pneumonia10.3
22sarcoidosis10.2
23thrombocytopenia10.2
24tuberculosis10.2
25obesity10.1
26mycosis fungoides10.1
27leptospirosis10.1
28agammaglobulinemia10.1
29hyperglycemia10.1
30mouth disease10.1
31osteomyelitis10.1
32pancreatitis10.1
33sarcoma10.1
34thymoma10.1
35thyroiditis10.1
36peripheral t-cell lymphoma10.1
37hematopoietic stem cell transplantation10.1
38acute lymphoblastic leukemia, childhood10.0RAG1, IL7
39human immunodeficiency virus infectious disease10.0IL7R, IL7
40molluscum contagiosum10.0
41protein-losing enteropathy10.0
42aspergillosis10.0
43esophagitis10.0
44histoplasmosis10.0
45retinitis10.0
46absent t lymphocytes10.0
47mycetoma10.0
48primary effusion lymphoma10.0
49gamma chain deficiency10.0IL2RG, IL7R, IL7
50burkitt's lymphoma10.0CD59, RAG1, IL7

Graphical network of the top 20 diseases related to Lymphopenia:



Diseases related to lymphopenia

Symptoms for Lymphopenia

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Drugs & Therapeutics for Lymphopenia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Lymphopenia

Search NIH Clinical Center for Lymphopenia

Genetic Tests for Lymphopenia

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Anatomical Context for Lymphopenia

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33MalaCards
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MalaCards organs/tissues related to Lymphopenia:

33
T cells, B cells, Breast, Thymus, Bone marrow, Bone, Thyroid, Testes, Lymph node, Brain, Heart, Liver, Skin, Endothelial, Nk cells, Pancreas, Lung, Kidney, Retina, Spleen, Whole blood, Appendix

Animal Models for Lymphopenia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Lymphopenia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.8RAG1, IL2RG, FOXP3, IL7R
2MP:00053888.5RAG1, IL2RG, FOXP3, PTPN22
3MP:00053818.4RAG1, IL2RG, PTPN22, FOXP3
4MP:00053798.0RAG1, FOXP3, PTPN22, CD59
5MP:00053677.9RAG1, CD59, PNP, PTPN22, FOXP3
6MP:00053767.4IL2RG, FOXP3, RAG1, CD59, PTPN22, PNP
7MP:00107687.4RAG1, IL2RG, FOXP3, PTPN22, PNP, CD59
8MP:00053877.1PNP, PTPN22, FOXP3, IL7, IL7R, RAG1
9MP:00053847.0PNP, PTPN22, CD59, RAG1, IL7R, FOXP3
10MP:00053976.6CD59, IL2RG, RAG1, IL7R, IL7, FOXP3

Publications for Lymphopenia

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52PubMed
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Articles related to Lymphopenia:

(show top 50)    (show all 476)
idTitleAuthorsYear
1
Risperidone/paliperidone induced neutropenia and lymphopenia. (22984110)
2013
2
Enigma of low-serum zinc, selenium, and prolactin with lymphopenia. (23648879)
2013
3
Antigen and lymphopenia-driven donor T cells are differentially diminished by post-transplantation administration of cyclophosphamide after hematopoietic cell transplantation. (23819914)
2013
4
Novel mutation in TP63 associated with ectrodactyly ectodermal dysplasia and clefting syndrome and T cell lymphopenia. (23613309)
2013
5
The etiology of treatment-related lymphopenia in patients with malignant gliomas: modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells. (23362951)
2013
6
In hospitalized adults the combined presence of leukocytosis, relative lymphopenia, and thrombocytopenia is predictive of swine influenza (H1N1). (23911963)
2013
7
Primary immunodeficiencies appearing as combined lymphopenia, neutropenia, and monocytopenia. (24316408)
2013
8
Lymphopenia following the completion of first-line therapy predicts early relapse in patients with diffuse large B cell lymphoma. (21811783)
2012
9
L-index as a novel index to evaluate both the intensity and duration of lymphopenia after allogeneic hematopoietic stem cell transplantation. (22469427)
2012
10
Preterm neonates show marked leukopenia and lymphopenia that are associated with increased regulatory T-cell values and diminished IL-7. (22398700)
2012
11
Human phagocyte defect caused by a Rac2 mutation detected by means of neonatal screening for T-cell lymphopenia. (21167572)
2011
12
CD4+ T-lymphopenia in HIV negative tuberculous patients at King Khalid University Hospital in Riyadh, Saudi Arabia. (21810564)
2011
13
Letter to the editor. Loss of plasmacytoid dendritic cell function coincides with lymphopenia and viremia during foot-and-mouth disease virus infection. (20565298)
2010
14
Low peripheral lymphocyte count before focal radiotherapy plus concomitant temozolomide predicts severe lymphopenia during malignant glioma treatment. (20805645)
2010
15
Autoimmunity during thymectomy-induced lymphopenia: role of thymus ablation and initial effector T cell activation timing in nonobese diabetic mice. (19801516)
2009
16
Cannabidiol-induced lymphopenia does not involve NKT and NK cells. (19996489)
2009
17
CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation. (19462377)
2009
18
Emphysematous pyelonephritis in a female with diabetes mellitus, renal calculi, breast cancer and chemotherapy-induced lymphopenia, successfully managed without nephrectomy. (20148471)
2009
19
IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis. (19637223)
2009
20
Regulatory CD4+CD25+Foxp3+ T cells selectively inhibit the spontaneous form of lymphopenia-induced proliferation of naive T cells. (18490730)
2008
21
Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. (16868248)
2006
22
Peripheral T cell lymphopenia and concomitant enrichment in naturally arising regulatory T cells: the case of the pre-Talpha gene-deleted mouse. (17015684)
2006
23
CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. (16272295)
2005
24
A major role for memory CD4 T cells in the control of lymphopenia-induced proliferation of naive CD4 T cells. (15843528)
2005
25
Congenital chylothorax: lymphopenia and high risk of neonatal infections. (15046278)
2004
26
Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. (14707092)
2004
27
Clonal expansion of CD8+ BV8 T lymphocytes in bone marrow characterizes thymoma-associated B lymphopenia. (12515721)
2003
28
CD4 cell lymphopenia and atherosclerosis in renal transplant recipients. (12595514)
2003
29
Impaired regeneration of the peripheral B cell repertoire from bone marrow following lymphopenia in old mice. (11180115)
2001
30
Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice. (11745397)
2001
31
B lymphopenia in uremia is related to an accelerated in vitro apoptosis and dysregulation of Bcl-2. (10727545)
2000
32
Therapeutic and prognostic implications of peripheral blood lymphopenia in patients with Hodgkin's disease. (10492075)
1999
33
CD4 lymphopenia in a patient with cryptococcal osteomyelitis. (9181663)
1997
34
High viral load and CD4 lymphopenia in rhesus and cynomolgus macaques infected by a chimeric primate lentivirus constructed using the env, rev, tat, and vpu genes from HIV-1 Lai. (8806570)
1996
35
Steroid resistant nephrotic syndrome associated with spondyloepiphyseal dysplasia, transient ischemic attacks and lymphopenia. (7736684)
1995
36
Bartonella (Rochalimaea) quintana isolation in patient with chronic adenopathy, lymphopenia, and a cat. (7909030)
1994
37
Prevalence of lymphopenia in children with AIDS. (8013166)
1994
38
The role of lymphocyte production and migration in the lymphopenia caused by 2-acetyl-4-tetrahydroxybutyl imidazole. (1521936)
1992
39
Peripheral blood lymphopenia in gangrenous appendicitis. (2393731)
1990
40
T4 lymphopenia in patients with active pulmonary tuberculosis. (3874015)
1985
41
SjAPgren's syndrome presenting with hypereosinophilia, lymphopenia and circulating immune complexes. (6241858)
1984
42
Lymphopenia and abnormal lymphocyte subsets in the "BB" rat: relationship to the diabetic syndrome. (6978807)
1982
43
Thymic hypoplasia and lymphopenia in a Siberian tiger. (4609964)
1974
44
Comments from the readers: thymic dysplasia associated with lymphopenia. (4641095)
1972
45
The effect of immunologically induced lymphopenia on antibody formation. (5765454)
1969
46
Studies of a method of inducing specific lymphopenia in dogs. (5897788)
1965
47
Observations upon the lymphopenia of x-ray irradiation. Part II. (14886582)
1951
48
The Common Causes of Lymphopenia. (16810891)
1950
49
A lymphopenia-causing agent, probably a virus, found in mice after injection with tumor tissue and with the cell-free filtrates of lymphosarcoma T 86157 (MB). (18150968)
1949
50
Primary Splenic Granulocytopenia and Lymphopenia. (19993276)
1946

Variations for Lymphopenia

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Expression for genes affiliated with Lymphopenia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphopenia

Search GEO for disease gene expression data for Lymphopenia.

Pathways for genes affiliated with Lymphopenia

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50PathCards, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems, 30KEGG, 53QIAGEN, 5Cell Signaling Technology
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Pathways related to Lymphopenia according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6FOXP3, IL2RG
2
Show member pathways
IL2 signaling events mediated by STAT538
9.6IL2RG, FOXP3
3
Show member pathways
9.6IL2RG, FOXP3
49.2IL7R, IL2RG, RAG1
5
Show member pathways
9.2IL7, IL7R, IL2RG
69.2IL7, IL7R, IL2RG
7
Show member pathways
IL-9 Signaling Pathway38
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway38
Immune response IL 9 signaling pathway60
9.2IL7, IL7R, IL2RG
8
Show member pathways
9.2IL7, IL7R, IL2RG
9
Show member pathways
9.2IL2RG, IL7R, IL7
10
Show member pathways
9.2IL2RG, IL7R, IL7
11
Show member pathways
Type III interferon signaling38
9.2IL2RG, IL7R, IL7
12
Show member pathways
9.2IL2RG, IL7R, IL7
13
Show member pathways
9.2IL2RG, IL7R, IL7
149.0CD59, IL7R, IL7
158.9PTPN22, FOXP3, RAG1
16
Show member pathways
8.3IL2RG, IL7R, IL7, PTPN22

Compounds for genes affiliated with Lymphopenia

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45Novoseek, 29IUPHAR, 3BitterDB, 51PharmGKB, 24HMDB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Lymphopenia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1caffeine45 29 3 51 24 1114.5RAG1, PNP
2methylcellulose459.4IL7, CD59
3ionomycin459.3IL7, IL7R, RAG1
4azathioprine45 3 51 1112.0CD59, PNP
5rapamycin459.0IL7, FOXP3, PNP
6cyclosporin a45 29 6110.8CD59, IL2RG, IL7, FOXP3
7tyrosine457.4CD59, PNP, PTPN22, IL7, IL7R, IL2RG

GO Terms for genes affiliated with Lymphopenia

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16Gene Ontology
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Biological processes related to Lymphopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-7-mediated signaling pathwayGO:0381119.6IL2RG, IL7R
2T cell homeostasisGO:0430299.6FOXP3, RAG1
3positive regulation of T cell proliferationGO:0421029.3CD59, PNP
4T cell differentiationGO:0302178.8IL7R, PTPN22
5immune responseGO:0069558.6RAG1, IL2RG, IL7R, PNP

Molecular functions related to Lymphopenia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-7 receptor activityGO:0049179.3IL2RG, IL7R
2protein bindingGO:0055157.0CD59, RAG1, IL2RG, IL7R, IL7, FOXP3

Products for genes affiliated with Lymphopenia

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Sources for Lymphopenia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet