Lymphopenia malady

Wikipedia: Lymphocytopenia, or lymphopenia, is the condition of having an abnormally low level of lymphocytes in...⁴⁴ more...

MalaCards: Lymphopenia, also known as lymphocytopenia (disorder), is related to t-lymphocytopenia and systemic lupus erythematosus. An important gene associated with Lymphopenia is RAG1 (recombination activating gene 1), and among its related pathways are Graft-versus-host disease and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds ivig and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, t cells and b cells, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Disease Ontology: A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood.⁶

Aliases & Descriptions:

lymphopenia 6 8 32 43 lymphocytopenia (disorder) 6

lymphocytopenia 6

Diseases related to lymphopenia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 637)

id	Related Disease	Score	Top Affiliating Genes
1	t-lymphocytopenia	33.9	LBR, CD59, IL2, IL2RB, IL4, IL7
2	systemic lupus erythematosus	30.4	FOXP3, FASLG, PTPN22, CTLA4
3	rheumatoid arthritis	29.2	CIITA, IL10, IL1RN, IL2, PTPN22, CTLA4
4	nucleoside phosphorylase deficiency	28.7	FAS, PNP, ADA
5	purine nucleoside phosphorylase deficiency	28.6	FAS, PNP, ADA
6	onchocerciasis	28.5	LBR, IL10, IL4, IFNG
7	turner syndrome	27.8	FOXP3, INS, IL2RB, IL6, PTPN22
8	multiple sclerosis	27.4	IL1RN, IL2RA, IL7R, IFNG, HLA-DQB1
9	t cell deficiency	27.0	ATM, CD4, IL15, IL2, IL2RG, IL4
10	meningitis	26.2	SELL, B2M, CD4, CD55, GSR, IL10
11	acute myocardial infarction	25.9	SELL, ITGB2, INS, GSR, IL10, IL18
12	myocardial infarction	25.3	SELL, CIITA, S1PR1, CD59, CD55, ITGB2
13	common variable immunodeficiency	24.9	SELL, LCK, LBR, B2M, CD28, CD69
14	severe combined immunodeficiency	24.5	RAG2, RAG1, CIITA, ZAP70, LCK, CD28
15	immunodeficiency	24.0	SELL, CIITA, ZAP70, LCK, S1PR1, CD28
16	obesity	24.0	SELL, CIITA, B2M, ITGB2, INS, GSR
17	combined immunodeficiency	23.8	RAG2, RAG1, CIITA, ZAP70, LCK, CD28
18	lupus erythematosus	21.3	SELL, RAG2, RAG1, LGALS8, CIITA, ZAP70
19	arthritis	19.0	SELL, RAG2, RAG1, LGALS8, CIITA, ZAP70
20	colorectal cancer	19.0	CIITA, ZAP70, LCK, LBR, B2M, ATM
21	pre-b-cell acute lymphoblastic leukemia	13.8	ZAP70, IL2RG, IL7, IL7R
22	dyserythropoietic anemia with thrombocytopenia	13.8	CD59, CD55, IL7, FAS
23	viral meningitis	13.7	B2M, IL6, ADA
24	lumbar disc degeneration	13.7	IL10, FASLG, FAS
25	t-cell large granular lymphocyte leukemia	13.7	IL18, IL2, IL2RB, FASLG
26	thyroid lymphoma	13.7	IL7, IL7R, FAS
27	prolymphocytic leukemia	13.7	ZAP70, ATM, ADA
28	berylliosis	13.7	IL2, IL2RB, IFNG
29	gamma heavy chain disease	13.7	IL15, IL2, IL2RG, IL4, IL7
30	pleural tuberculosis	13.7	IL18, IL2RA, IFNG, ADA
31	tuberculoid leprosy	13.7	IL10, IL2RA, IFNG
32	rasmussen encephalitis	13.7	GSR, IL15, IL18
33	bcg infection	13.7	IL4, FAS, IFNG, ADA
34	miliary tuberculosis	13.7	IL10, IL18, IFNG, ADA
35	extramedullary plasmacytoma	13.6	B2M, IL2, IL2RB, IL6
36	eosinophilic meningitis	13.6	IL10, IL2, IL4
37	hematologic cancer	13.6	IL2, IL2RA, IL2RB
38	radiculopathy	13.6	IL15, IL2RA, IL6, IL7
39	periodic fever	13.6	IL1RN, ANXA5, IFNG, TNFRSF1B
40	membranous glomerulonephritis	13.6	CD59, CD55, ITGB2, IFNG
41	post-transplant lymphoproliferative disease	13.6	B2M, IL10, IL6, TNFRSF1B
42	castleman's disease	13.6	B2M, IL10, IL6, IL7
43	panniculitis	13.6	IL2RA, IL2RB, FAS, IFNG
44	egg allergy	13.6	IL2, IL4, IFNG
45	posterior uveitis	13.6	IL2RA, IL2RB, FASLG, FAS, IFNG
46	extrapulmonary tuberculosis	13.6	IL10, IL1RN, IFNG, ADA
47	hairy cell leukemia	13.6	ITGB2, IL2, IL2RA, IL2RB, ADA
48	psoriatic arthritis	13.6	IL10, IL1RN, IL6
49	visceral leishmaniasis	13.6	IL10, IL4, IFNG
50	meningococcal infection	13.6	GSR, IL10, IL1RN, TNFRSF1B, ADRB2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to lymphopenia:

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MGI Mouse Phenotypes related to lymphopenia:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.8	G6PC3, CTLA4, IFNG, FASLG, IL2RB, IL2
2	renal/urinary system phenotype	MP:0005367	9.6	PNP, TNFRSF1B, INS, CD55, FYN, RAG1
3	respiratory system phenotype	MP:0005388	9.6	ADA, ACHE, PTPN22, IKZF1, IL2RG, RAG1
4	liver/biliary system phenotype	MP:0005370	8.8	ADA, CTLA4, PTPN22, GIMAP5, IFNG, IKZF1
5	reproductive system phenotype	MP:0005389	8.5	IL2RG, IL4, IL6, FASLG, IFNG, ERCC2
6	vision/eye phenotype	MP:0005391	8.0	IL6, FASLG, FAS, IFNG, ERCC2, TNFRSF1B
7	tumorigenesis	MP:0002006	7.9	FAS, IKZF1, IFNG, CAT, ERCC2, TNFRSF1B
8	skeleton phenotype	MP:0005390	7.7	ADA, CTLA4, CTBP1, TERT, TNFRSF1B, ERCC2
9	no phenotypic analysis	MP:0003012	7.6	ADRB2, ACHE, INS, FOXP3, CD4, CD69
10	integument phenotype	MP:0010771	7.6	IL4, FASLG, FAS, IKZF1, IFNG, ERCC2
11	digestive/alimentary phenotype	MP:0005381	7.5	IKZF1, IFNG, GIMAP5, TERT, CTLA4, IL18
12	muscle phenotype	MP:0005369	7.5	HLA-DQB1, TNFRSF1B, SPHK2, CTBP1, ACHE, IFNG
13	hematopoietic system phenotype	MP:0005397	7.1	ADA, NHEJ1, FOXP3, CD8A, CD69, CD28
14	behavior/neurological phenotype	MP:0005386	6.7	IL2RB, IL6, FAS, IFNG, ERCC2, HLA-DQB1
15	growth/size phenotype	MP:0005378	6.6	ERCC2, GIMAP5, IKZF1, FAS, TERT, PTPN22
16	cardiovascular system phenotype	MP:0005385	6.4	IL6, FASLG, FAS, MAP3K3, IFNG, HLA-DQB1
17	nervous system phenotype	MP:0003631	5.8	FASLG, ERCC2, HLA-DQB1, TNFRSF1B, TERT, SPHK2
18	immune system phenotype	MP:0005387	5.7	PTPN22, CD4, FYN, ATM, S1PR1, LBR
19	normal phenotype	MP:0002873	5.5	IL4, IL7R, FASLG, ANXA5, MAGT1, IFNG
20	mortality/aging	MP:0010768	5.2	ADA, IFNG, IKZF1, MAP3K3, IL6, IL2RG
21	homeostasis/metabolism phenotype	MP:0005376	4.3	SELL, ACHE, PNP, CTLA4, SPHK2, PTPN22
22	cellular phenotype	MP:0005384	2.6	NHEJ1, PNP, CTLA4, SPHK2, PTPN22, TERT

Articles related to lymphopenia:

(show all 29)

id	Title	Authors	Year	Affiliating Genes
1	Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations. (21502542)	Kuijpers T.W.... van der Burg M.	2011	RAG1
2	Elevated IL-7 availability does not account for T cel l proliferation in moderate lymphopenia. (21239710)	Osborne L.C.... Abraham N.	2011	IL7
3	Irradiation and IL-15 promote loss of CD8 T-cell tole rance in response to lymphopenia. (20075162)	Oelert T.... SchA1ler T.	2010	IL15
4	Autoimmune B-cell lymphopenia after successful adopti ve therapy with telomerase-specific T lymphocytes. (19903903)	Ugel S.... Bronte V.	2010	TERT
5	CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation. (19462377)	Sojka D.K.... Fowell D.J.	2009	CTLA4
6	Safety and efficacy of treatment using interleukin-2 in a patient with idiopathic CD4(+) lymphopenia and Mycobacterium avium-intracellulare. (19438596)	Trojan T.... Khan D.A.	2009	IL2
7	Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. (19395456)	Massardo L.... Soza A.	2009	LGALS8
8	MEKK3 is essential for lymphopenia-induced T cell proliferation and survival. (19265138)	Wang X.... Su B.	2009	MAP3K3
9	Cachexia in the non-obese diabetic mouse is associated with CD4+ T-cell lymphopenia. (18397274)	Zhao C.... Davies J.D.	2008	RPS27A, FBXO32
10	IL-7 serum levels and lymphopenia in hemodialysis patients, non-responders to recombinant human erythropoietin therapy. (18375155)	Costa E.... Santos-Silva A.	2008	IL7
11	Acetylcholinesterase/C terminal binding protein interactions modify Ikaros functions, causing T lymphopenia. (17476278)	Perry C.... Soreq H.	2007	ACHE, CTBP1, IKZF1
12	Severe FOXP3+ and naive T lymphopenia in a non-IPEX form of autoimmune enteropathy combined with an immunodeficiency. (17484867)	Zuber J.... Bandeira A.	2007	FOXP3
13	Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control. (17457102)	Fluur C.... Chiodi F.	2007	IL7
14	Diminished expression of complement regulatory proteins (CD55 and CD59) in lymphocytes from systemic lupus erythematosus patients with lymphopenia. (17080916)	GarcA-a-Valladares I.... Llorente L.	2006	CD55, CD59
15	Interleukin 7 receptor alpha-chain-mutation severe combined immunodeficiency without lymphopenia: correction with haploidentical T-cell-depleted bone marrow transplantation. (17201233)	Ponda P.... Bonagura V.R.	2006	IL7R
16	Normal interleukin-7 (IL7) levels and normal IL7 response to CD4 T lymphopenia in patients with multiple sclerosis and systemic sclerosis. (16844418)	Storek J.... Sullivan K.M.	2006	IL7
17	A novel mutation in the interleukin-2 receptor gamma gene as the cause of lymphopenia in a neonate vertically exposed to human immunodeficiency virus. (15702055)	Neubert J.... Niehues T.	2005	IL2RG
18	Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia. (15642146)	Ponchel F.... Isaacs J.D.	2005	IL7
19	Two patients with cryptococcal meningitis and idiopat hic CD4 lymphopenia: defective cytokine production and reversal by recombinant interferon- gamma therapy. (15494899)	Netea M.G.... Kullberg B.J.	2004	IFNG, IL10
20	Purine nucleoside phosphorylase deficiency (PNP-def) presenting with lymphopenia and developmental delay: successful correction with umbilical cord blood transplantation. (15520787)	Myers L.A.... Kurtzberg J.	2004	PNP
21	Recurrent 'sterile' verrucous cyst abscesses and epidermodysplasia verruciformis-like eruption associated with idiopathic CD4 lymphopenia. (14511000)	Tobin E.... Carlson J.A.	2003	IFNG
22	IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia. (12660531)	Carcelain G.... Autran B.	2003	IL2
23	Lymphopenia in dialysis patients: a preliminary study indicating a possible role of apoptosis. (11924754)	Bhaskaran M.... Singhal P.C.	2002	FASLG
24	Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene. (12097339)	MacMurray A.J.... Lernmark A.	2002	GIMAP6
25	Defective dendritic cell maturation in a child with nucleotide excision repair deficiency and CD4 lymphopenia. (11737070)	Racioppi L.... Rossi P.	2001	ERCC2
26	T lymphopenia in genetically obese-diabetic Wistar fa tty rats: effects of body weight reduction on T cells. (11079813)	Tanaka S.... Yamakawa T.	2000	INS
27	The lymphopenia (lyp) gene controls the intrathymic cytokine ratio in congenic BioBreeding rats. (9243099)	Bieg S.... Lernmark A.	1997	PTPN22
28	Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): a possible mechanism for lymphopenia. (7531628)	Amasaki Y.... Koike T.	1995	FAS
29	Relationship between susceptibility to apoptosis and Fas expression in peripheral blood T cells from uremic patients: a possible mechanism for lymphopenia in chronic renal failure. (7575631)	Matsumoto Y.... Maeda K.	1995	FAS

Genes related to lymphopenia according to GeneCards:

(show top 50)    (show all 65)

id	Symbol	Description	Score	GeneCards Section Context
1	RAG1	recombination activating gene 1	11.0	Publications
2	IDDM2	insulin-dependent diabetes mellitus 2	11.0
3	IL2RG	interleukin 2 receptor, gamma	11.0	Publications
4	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
5	PNP	purine nucleoside phosphorylase	11.0	Publications
6	IL7R	interleukin 7 receptor	11.0	Publications
7	IL7	interleukin 7	11.0	Publications
8	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications
9	FOXP3	forkhead box P3	11.0	Publications
10	CIITA	class II, major histocompatibility complex, transactivator	11.0
11	LBR	lamin B receptor	11.0
12	ZAP70	zeta-chain (TCR) associated protein kinase 70kDa	11.0
13	ADRB2	adrenoceptor beta 2, surface	11.0
14	ANXA5	annexin A5	11.0
15	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0
16	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
17	SELL	selectin L	11.0
18	ADA	adenosine deaminase	11.0
19	TNFRSF1B	tumor necrosis factor receptor superfamily, member 1B	11.0
20	IL2RB	interleukin 2 receptor, beta	11.0
21	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications
22	IL15	interleukin 15	11.0	Publications
23	LCK	lymphocyte-specific protein tyrosine kinase	11.0
24	CD28	CD28 molecule	11.0
25	GSR	glutathione reductase	11.0
26	B2M	beta-2-microglobulin	11.0
27	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0
28	IL2	interleukin 2	11.0	Publications
29	IL1RN	interleukin 1 receptor antagonist	11.0
30	IL2RA	interleukin 2 receptor, alpha	11.0
31	IL4	interleukin 4	11.0
32	CD55	CD55 molecule, decay accelerating factor for complement (Cromer blood group)	11.0	Publications
33	ATM	ataxia telangiectasia mutated	11.0
34	CAT	catalase	11.0
35	FYN	FYN oncogene related to SRC, FGR, YES	11.0
36	IL10	interleukin 10	11.0	Publications
37	IL6	interleukin 6 (interferon, beta 2)	11.0
38	IFNG	interferon, gamma	11.0	Publications
39	G6PC3	glucose 6 phosphatase, catalytic, 3	11.0
40	GIMAP1	GTPase, IMAP family member 1	11.0
41	GIMAP6	GTPase, IMAP family member 6	11.0	Publications
42	GIMAP5	GTPase, IMAP family member 5	11.0
43	MAGT1	magnesium transporter 1	11.0
44	CD52	CD52 molecule	11.0
45	ART1	ADP-ribosyltransferase 1	11.0
46	SPHK2	sphingosine kinase 2	11.0
47	RAG2	recombination activating gene 2	11.0
48	IKZF1	IKAROS family zinc finger 1 (Ikaros)	11.0	Publications
49	LGALS8	lectin, galactoside-binding, soluble, 8	11.0	Publications
50	FBXO32	F-box protein 32	11.0	Publications

Pathways related to lymphopenia according to GeneDecks:

(show top 50)    (show all 82)

id	Pathway	Score	Top Affiliating Genes
1	Graft-versus-host disease20	10.6	CD28, IL2, FASLG
2	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.4	IL2RB, IL2RA, IL2, IL15, IL2RG, FASLG
3	RAR-Gamma-RXR-Alpha Degradation36	10.2	IL15, IL2, IL7
4	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.2	TNFRSF1B, FAS, FASLG, IL2RG, IL2RB, IL2RA
5	African trypanosomiasis20	10.1	IFNG, FAS, FASLG, IL6, IL18, IL10
6	Jak-STAT signaling pathway20	10.1	IL7R, IL7, IL4, IL2RG, IL2RB, IL2RA
7	Cytokine Network36	10.1	IFNG, IL6, IL4, IL2, IL18, IL15
8	MIF Mediated Glucocorticoid Regulation36	10.0	IL7, IL6, IL4, IL2, IL18, IL15
9	MIF Regulation of Innate Immune Cells36	9.9	IL7, IL6, IL4, IL2, IL18, IL15
10	Natural killer cell mediated cytotoxicity20	9.8	IFNG, FAS, FASLG, ITGB2, FYN, LCK
11	Primary immunodeficiency20	9.8	IL2RG, CD4, CIITA, RAG2
12	Measles20	9.8	IFNG, FAS, FASLG, IL6, IL4, IL2RG
13	Immune System38	9.8	CTLA4, IFNG, MAP3K3, IL7R, IL2RG, IL18
14	all-trans-Retinoic Acid Signaling in Brain36	9.7	IL7, IL6, IL4, IL2, IL18, IL15
15	NFAT Signaling and Lymphocyte Interactions36	9.6	IL7, IL4, IL2RG, IL2RB, IL2, IL15
16	Cytokine-cytokine receptor interaction20	9.6	IL7, IL7R, FASLG, FAS, IFNG, TNFRSF1B
17	Intestinal immune network for IgA production20	9.5	HLA-DQB1, IL6, IL4, IL2, IL15, IL10
18	Allograft rejection20	9.5	HLA-DQB1, IFNG, FAS, FASLG, IL4, IL2
19	PEDF Induced Signaling36	9.5	IL7, IL6, IL4, IL2, IL18, IL15
20	THC Differentiation Pathway36	9.5	CD28, IL10, IL18, IL2, IL2RA, IL4
21	PGC1Alpha Pathway36	9.4	TNFRSF1B, IL7R, IL7, IL4, IL2RG, IL2RB
22	Th1 Differentiation37	9.4	IFNG, IL2, IL18, IL10, CD4, CD28
23	Autoimmune thyroid disease20	9.3	CTLA4, HLA-DQB1, FAS, FASLG, IL4, IL2
24	Tuberculosis20	9.2	SPHK2, HLA-DQB1, IFNG, IL6, IL18, IL10
25	Rheumatoid arthritis20	9.2	CTLA4, HLA-DQB1, IFNG, IL6, IL18, IL15
26	Type I diabetes mellitus20	9.2	HLA-DQB1, IFNG, FAS, FASLG, IL2, INS
27	Hematopoietic cell lineage20	9.1	IL7R, IL7, IL6, IL4, IL2RA, CD55
28	Molecular Mechanisms of Cancer36	9.1	TNFRSF1B, IL7R, IL7, IL6, IL2RG, IL2
29	Glucocorticoid Receptor Signaling36	9.0	IL4, IL6, IL7, IL7R, TNFRSF1B, IL2RG
30	TGF-Beta Pathway36	9.0	IL4, IL6, IL7, IL7R, TNFRSF1B, IL2RG
31	Lymphocyte Signaling3	9.0	FOXP3, CD4, CD8A, B2M, LCK, ZAP70
32	STAT3 Pathway36	8.9	IL2RG, IL4, IL6, IL7, IL7R, TNFRSF1B
33	Immune response IL-22 signaling pathway10	8.9	HLA-DQB1, IL2RG, IL2RB, IL2RA, IL2, CD4
34	Immune response_IL-22 signaling pathway41	8.9	HLA-DQB1, IL2RG, IL2RB, IL2RA, IL2, CD4
35	Akt Signaling36	8.9	IL2RB, IL2RG, IL4, IL6, IL7, IL7R
36	JAK-STAT Pathway36	8.8	IL4, IL6, IL7, IL7R, IFNG, TNFRSF1B
37	Cell adhesion molecules (CAMs)20	8.8	CTLA4, ITGB2, CD4, CD8A, CD28, SELL
38	ICos-ICosL Pathway in T-Helper Cell36	8.8	HLA-DQB1, IL2RG, IL2RB, IL2RA, IL2, CD4
39	Tec Kinases Signaling36	8.8	IL2RG, IL4, IL6, IL7, IL7R, TNFRSF1B
40	Antigen processing and presentation20	8.8	HLA-DQB1, CD4, CD8A, CIITA
41	MAPK Family Pathway36	8.8	IL4, IL6, IL7, IL7R, MAP3K3, TNFRSF1B
42	SOCS Pathway36	8.7	IL7, IL6, IL4, IL2, IL18, IL15
43	Regulation of eIF4 and p70S6K36	8.7	IL7, IL6, IL4, IL2, IL18, IL15
44	Antioxidant Action of Vitamin-C36	8.6	IL4, IL6, IL7, IL7R, MAP3K3, TNFRSF1B
45	CD28 Signaling in T-Helper Cell36	8.6	CTLA4, HLA-DQB1, CD4, CD28, FYN, ZAP70
46	T cell receptor signaling pathway20	8.6	CTLA4, IFNG, IL4, IL2, IL10, CD4
47	p38 Signaling36	8.5	IL7R, MAP3K3, TNFRSF1B, IL7, IL6, ZAP70
48	PKC-Theta Pathway36	8.4	HLA-DQB1, MAP3K3, CD4, CD8A, CD28, FYN
49	CTLA4 Signaling36	8.4	CTLA4, PTPN22, HLA-DQB1, CD4, CD8A, CD28
50	TCR Signaling36	8.1	CTLA4, HLA-DQB1, MAP3K3, CD4, CD8A, CD28

Compounds related to lymphopenia according to GeneDecks:

(show top 50)    (show all 250)

id	Compound	Score	Top Affiliating Genes
1	ivig32	10.8	FASLG
2	cyclophosphamide32 34 9 9	13.8	ITGB2
3	ionomycin32	10.1	RAG1, IL7R, IL7, CD69, FYN, LCK
4	cuprophan32	9.9	IL2RB, SELL, LBR, B2M, ITGB2, IL1RN
5	il-1232	9.8	IFNG, IL2, IL7, IL4, IL6, IL15
6	okt332	9.8	FAS, IL7, IL6, IL2RB, IL2RA, IL2
7	tuberculin32	9.8	IL10, IL2RA, IL15, ADA, IFNG, IL18
8	pentoxifylline32 9 9	11.6	LBR, SELL, ITGB2, IL10, IFNG, IL6
9	rituximab32 34 9 9	12.6	IL15, IL10, CD55, CD52, CD59, ZAP70
10	thalidomide32 42 9 9	12.5	TNFRSF1B, IFNG, FASLG, IL6, IL2, IL18
11	fludarabine32 9 9	11.4	PNP, ANXA5, FAS, FASLG, ADA, CD55
12	infliximab32 9 9	11.3	LBR, IL6, IL4, IL2RB, IL2RA, IL1RN
13	histamine32 18	10.3	IL6, IL4, IL2RB, IL2RA, IL2, IL1RN
14	h2o232	9.3	RPS27A, PNP, TNFRSF1B, SELL, ZAP70, LCK
15	pge232	9.3	FASLG, IL1RN, GSR, FOXP3, CD4, CD69
16	fitc32	9.3	IL2RA, IL2RB, ANXA5, TNFRSF1B, CD55, CD4
17	prednisolone32 9 9	11.3	IL6, IFNG, IL2, SELL, ITGB2, IL10
18	estrogen32	9.2	ADRB2, RPS27A, INS, GSR, IL18, IL1RN
19	con a32	9.2	CTLA4, TNFRSF1B, IFNG, IL4, IL2RB, IL2RA
20	nitric oxide32 9 18 9	12.2	IL7, IL6, IL1RN, IL18, IL15, FOXP3
21	il 1032	9.1	IL15, IL10, CD8A, IL18, IL1RN, TNFRSF1B
22	ly29400232	9.1	ITGB2, CD69, S1PR1, IL18, IL4, IL6
23	creatinine32	9.0	SELL, B2M, CD55, IL15, IL18, IL1RN
24	indomethacin32 9 9	11.0	SELL, IL4, IL2RA, IL2, IL1RN, IL18
25	epinephrine32 9 18 9	11.9	ADRB2, ADA, CD69, INS, IL1RN, GSR
26	oxygen32 18	9.8	CIITA, IL15, GSR, CD59, CD69, FYN
27	neopterin32	8.8	CD4, B2M, LBR, IL10, IL18, TNFRSF1B
28	methotrexate32 34 42 9 9	12.7	CTLA4, IL2RB, IL6, FASLG, ADA, IL2RA
29	rapamycin32 42	9.7	RPS27A, PNP, TERT, IFNG, FBXO32, IL2RB
30	chloroquine32 34 9 9	11.7	IL4, RPS27A, TNFRSF1B, CIITA, IL2, IL1RN
31	vegf32	8.6	FYN, S1PR1, LCK, ADRB2, RPS27A, TERT
32	lactate32	8.5	ADA, ADRB2, GSR, INS, ITGB2, CD59
33	herbimycin a32 42	9.3	SELL, LCK, IL6, IL4, IL2, ITGB2
34	tacrolimus32 34 9 9	11.3	IL2RA, IL2, IL18, IL15, IL10, INS
35	cysteine32	8.2	FASLG, IFNG, TNFRSF1B, TERT, PNP, RPS27A
36	cisplatin32 34 9 9	11.2	IL2, TERT, TNFRSF1B, LBR, ERCC2, ANXA5
37	polysaccharide32	8.1	LGALS8, IL2RB, IL2RA, IL18, ITGB2, CD52
38	rantes32	8.1	TNFRSF1B, IFNG, FAS, FASLG, IL7, IL6
39	cyclosporin a32 42	9.0	CD69, CD28, FYN, B2M, LBR, CIITA
40	glutamate32	7.9	ADA, CD4, LCK, ITGB2, INS, GSR
41	thymidine32 18	8.8	ADRB2, IL2RA, IL2, IL18, IL15, IL10
42	genistein32 9 18 9	10.4	CD4, TERT, IFNG, ITGB2, GSR, IL2
43	cholesterol32 9 18 9	10.3	TNFRSF1B, CTLA4, FASLG, ERCC2, IL7, CIITA
44	cycloheximide32	7.2	SELL, ANXA5, IFNG, CAT, TNFRSF1B, RPS27A
45	alanine32	6.9	SELL, RAG1, CIITA, LCK, B2M, FYN
46	dexamethasone32 42 34 9 9	10.7	CIITA, RAG1, SELL, ZAP70, LCK, ADA
47	phosphatidylinositol32	6.3	ITGB2, INS, IL15, IL1RN, IL2RA, IL2RB
48	lipid32	6.2	CIITA, ZAP70, LCK, LBR, S1PR1, ATM
49	serine32	5.3	CD28, CD69, CD4, CD55, ITGB2, INS
50	tyrosine32	4.4	CD28, CD69, CD8A, CD59, CD4, CD55

Cellular components related to lymphopenia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	T cell receptor complex	GO:042101	9.3	ZAP70, CD8A, CD4
2	extracellular space	GO:005615	8.6	IL4, IL6, IL7, FASLG, IFNG, ADA
3	integral to plasma membrane	GO:005887	8.3	IL2RB, IL2RG, FASLG, MAGT1, CTLA4, ADRB2
4	extracellular region	GO:005576	7.8	IL7, IL7R, FASLG, FAS, IFNG, TNFRSF1B
5	external side of plasma membrane	GO:009897	7.6	SELL, ADA, CTLA4, IFNG, ANXA5, FAS
6	plasma membrane	GO:005886	5.6	IL2RB, IL2RG, IL7R, FAS, CAT, HLA-DQB1

Biological processes related to lymphopenia according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-2-mediated signaling pathway	GO:038110	10.6	IL2RG, IL2RB, IL2RA
2	positive regulation of T cell differentiation	GO:045582	10.6	IL7, IL4, ZAP70
3	positive regulation of alpha-beta T cell differentiation	GO:046638	10.6	ADA, PNP, ZAP70
4	positive regulation of tissue remodeling	GO:034105	10.6	IL2, IL18, IL15
5	type 2 immune response	GO:042092	10.5	IL4, IL18, IL10
6	positive regulation of interleukin-17 production	GO:032740	10.5	IL15, IL18, IL2
7	pre-B cell allelic exclusion	GO:002331	10.5	ATM, RAG1, RAG2
8	positive regulation of isotype switching to IgG isotypes	GO:048304	10.5	IFNG, IL4, IL2
9	positive regulation of B cell proliferation	GO:030890	10.4	ADA, IL7, IL4, IL2
10	positive regulation of MHC class II biosynthetic process	GO:045348	10.4	CIITA, IL10, IL4, IFNG
11	negative regulation of nitric oxide biosynthetic process	GO:045019	10.4	GIMAP5, IL4, IL10
12	humoral immune response	GO:006959	10.3	IFNG, IL7, IL6, CD28
13	negative regulation of inflammatory response	GO:050728	10.3	IL2, TNFRSF1B, ADRB2, ADA
14	interleukin-7-mediated signaling pathway	GO:038111	10.3	IL7R, IL2RG
15	positive regulation of T cell proliferation	GO:042102	10.3	PNP, IFNG, IL6, IL4, IL15, CD28
16	positive regulation of activated T cell proliferation	GO:042104	10.3	IL4, IL2, IL18
17	T cell activation	GO:042110	10.2	ADA, FOXP3, CD8A, ZAP70
18	regulation of isotype switching	GO:045191	10.2	IL4, IL10
19	negative regulation of B cell proliferation	GO:030889	10.1	CTLA4, IL10, ATM
20	regulation of immune response	GO:050776	10.0	SELL, B2M, CD8A, ITGB2, IL4
21	B cell differentiation	GO:030183	10.0	NHEJ1, GIMAP1, IL4, IL10, RAG1, RAG2
22	inflammatory cell apoptotic process	GO:006925	10.0	FAS, FASLG
23	response to drug	GO:042493	9.9	PNP, IFNG, FAS, IL4, IL1RN, IL10
24	response to hypoxia	GO:001666	9.9	ADA, ERCC2, CAT, FAS, IL18, ATM
25	positive regulation of apoptotic process	GO:043065	9.8	ADRB2, CTLA4, ANXA5, FAS, FASLG, ATM
26	cell-cell signaling	GO:007267	9.7	FASLG, IL7, IL2, IL18, IL15, IL10
27	regulation of defense response to virus by virus	GO:050690	9.6	CD4, CD28, FYN, B2M, LCK
28	cell surface receptor signaling pathway	GO:007166	9.5	ADRB2, IFNG, IL7R, IL2RA, CD4, CD59
29	positive regulation of calcium-mediated signaling	GO:050850	9.5	ZAP70, CD4, ADA
30	anti-apoptosis	GO:006916	9.4	RPS27A, SPHK2, TERT, ANXA5, FAS, IL2
31	cytokine-mediated signaling pathway	GO:019221	9.3	RPS27A, HLA-DQB1, IFNG, IL6, IL2RB, B2M
32	T cell differentiation	GO:030217	9.2	NHEJ1, PTPN22, GIMAP5, GIMAP1, IL2, CD4
33	negative regulation of apoptotic process	GO:043066	9.2	ERCC2, GIMAP5, CAT, IL7, IL6, IL4
34	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.1	ADRB2, RPS27A, ERCC2, IFNG, IL6, IL4
35	T cell costimulation	GO:031295	8.8	CTLA4, HLA-DQB1, CD4, CD28, FYN, LCK
36	T cell receptor signaling pathway	GO:050852	8.7	RPS27A, PTPN22, HLA-DQB1, CD4, FYN, LCK
37	immune response	GO:006955	7.9	RAG1, PNP, CTLA4, HLA-DQB1, FASLG, IL7R

Molecular functions related to lymphopenia according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-7 receptor activity	GO:004917	10.4	IL7R, IL2RG
2	interleukin-2 receptor activity	GO:004911	10.3	IL2RG, IL2RB, IL2RA
3	CD8 receptor binding	GO:042610	10.2	LCK, FYN
4	interleukin-2 binding	GO:019976	10.1	IL2RG, IL2RB
5	cytokine activity	GO:005125	9.7	IL10, IFNG, FASLG, IL7, IL6, IL4
6	glycoprotein binding	GO:001948	9.3	LCK, FYN, CD4, ITGB2
7	protein binding	GO:005515	4.7	TNFRSF1B, ERCC2, MAP3K3, FAS, FASLG, IL7R