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Lymphoproliferative Syndrome malady
43 genes, 4 tissues, 439 related diseases, 21 phenotypes, 75 articles, clinical trials.

Summaries for Lymphoproliferative Syndrome

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MalaCards: Lymphoproliferative Syndrome, also known as lymphoproliferative disorders, is related to autoimmune lymphoproliferative syndrome and lymphoproliferative disease, x-linked. An important gene associated with Lymphoproliferative Syndrome is SH2D1A (SH2 domain containing 1A), and among its related pathways are Apoptosis and survival Caspase cascade and Apoptosis and survival_Caspase cascade. The compounds mitomycin c and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, nk cells and t cells, and related mouse phenotypes are liver/biliary system and respiratory system.

Aliases & Descriptions for Lymphoproliferative Syndrome

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7diseasecard, 32Novoseek , 8DISEASES, 43UMLS
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lymphoproliferative syndrome 7 32
lymphoproliferative disorders 32 43
lymphoproliferative disease 8

Related Diseases for Lymphoproliferative Syndrome

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13GeneCards, 14GeneDecks
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Diseases related to lymphoproliferative syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 436)
idRelated DiseaseScoreTop Affiliating Genes
1autoimmune lymphoproliferative syndrome33.3CD4, IL10, IL2RA, FASLG, FAF1, FADD
2lymphoproliferative disease, x-linked32.1SH2D1A, XIAP
3caspase-8 deficiency31.9FAS, CASP10, CASP8, TNFSF10
4hemophagocytic lymphohistiocytosis28.9SH2D1A, IL2RA, PRF1
5hairy cell leukemia28.8CD5, IL2, IL2RA, IFNA2, PTPRC
6plasma cell leukemia28.1CD40LG, NRAS, KRAS
7hepatitis c27.7CD40LG, IL10, IL2, FAS, IFNA2, PTPRC
8eosinophilia27.4CD4, IL10, IL2, IL2RA, FAS, IGHE
9mantle cell lymphoma27.3BCL2, CD40LG, CD5, IL10, IL2, FAF1
10protein s deficiency27.3SH2D1A, ITK, IL2, IL2RA, PTPN11, SPP1
11splenomegaly27.3CD5, ITK, IL10, IL2RA, FASLG, FAS
12cryoglobulinemia27.2BCL2, CD27, CD40LG, CD5, IL10, FASLG
13anaplastic large cell lymphoma27.1BCL2, CD4, IL10, IL2, IL2RA, FAS
14waldenstrom macroglobulinemia26.9BCL2, CD27, CD40LG, IL10, PTPRC, SRC
15autoimmune hepatitis26.6CD40LG, IL10, IL2, IL2RA, FAS, IGHE
16infectious mononucleosis26.5SH2D1A, CD4, CD40LG, CD244, IL10, IL2
17hodgkin's lymphoma26.5SH2D1A, BCL2, XIAP, IL2, IL2RA, PTPRC
18common variable immunodeficiency26.4SH2D1A, XIAP, CD27, CD40LG, IL10, IL2
19b-cell non-hodgkin lymphoma26.3SH2D1A, BCL2, IL10, IL2, IL2RA, FASLG
20severe combined immunodeficiency26.2BCL2, CD27, CD4, CD40LG, CD5, IL10
21t-cell leukemia26.1BCL2, XIAP, FYN, CD4, IL2, IL2RA
22immunodeficiency26.0CD4, CD40LG, IL10, IL2, IL2RA, FASLG
23burkitt's lymphoma26.0SH2D1A, BCL2, XIAP, CD27, CD40LG, INPP5D
24combined immunodeficiency25.9BCL2, CD27, CD4, CD40LG, CD5, IL10
25wiskott-aldrich syndrome25.8SH2D1A, FYN, CD40LG, ITK, INPP5D, IL2
26non-hodgkin lymphoma25.4SH2D1A, BCL2, XIAP, CD27, CD5, IL2
27cytomegalovirus infection25.4BCL2, CD40LG, IL10, IL2, IL2RA, FAS
28gastritis25.3SH2D1A, BCL2, CD4, CD40LG, IL10, IL2
29vasculitis25.1SH2D1A, CD4, CD40LG, IL10, IL2, IL2RA
30sarcoidosis25.0CD27, CD4, IL10, IL2, IL2RA, FASLG
31systemic lupus erythematosus25.0CD27, CD4, CD40LG, IL10, IL2, IL2RA
32purpura24.7CD40LG, CD5, IL10, IL2, IL2RA, FASLG
33chronic lymphocytic leukemia23.4BCL2, XIAP, CD27, CD4, CD40LG, CD84
34pneumonia23.3BCL2, CD4, CD40LG, ITK, IL10, IL2
35fibrosis23.1BCL2, CD4, CD40LG, IL10, IL2, IL2RA
36anemia22.3SH2D1A, BCL2, CD4, CD40LG, CD5, ITK
37arthritis20.9SH2D1A, BCL2, XIAP, CD27, CD4, CD40LG
38rheumatoid arthritis20.9SH2D1A, BCL2, XIAP, CD27, CD4, CD40LG
39lymphocytic leukemia20.0BCL2, XIAP, CD27, CD4, CD40LG, CD84
40lupus erythematosus19.6BCL2, FYN, CD27, CD4, CD40LG, CD244
41leukemia19.6SH2D1A, BCL2, XIAP, FYN, CD27, CD4
42multiple myeloma18.8BCL2, XIAP, FYN, CD27, CD4, CD40LG
43hepatitis18.6BCL2, XIAP, FYN, CD27, CD4, CD40LG
44myeloma18.3BCL2, XIAP, FYB, FYN, CD27, CD4
45lumbar disc degeneration13.6IL10, FASLG, FAS
46pancytopenia13.6SH2D1A, XIAP, ITK, IL2RA
47intestine carcinoma in situ13.6FASLG, FAS, CASP10, KRAS
48cowpox13.5XIAP, FAS, CASP8, TNFSF10
49tuberculoid leprosy13.5IL10, IL2RA
50cardiofaciocutaneous syndrome13.5HRAS, PTPN11, KRAS

Graphical network of the top 20 diseases related to lymphoproliferative syndrome:



Graphical network of diseases related to lymphoproliferative syndrome

Clinical Features for Lymphoproliferative Syndrome

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Drugs & Therapeutics for Lymphoproliferative Syndrome

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Genetic Tests for Lymphoproliferative Syndrome

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Anatomical Context for Lymphoproliferative Syndrome

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MalaCards organs/tissues related to lymphoproliferative syndrome:

22
Bone marrow, Nk cells, T cells, B cells

Phenotypes for genes affiliated with Lymphoproliferative Syndrome

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25MGI
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MGI Mouse Phenotypes related to lymphoproliferative syndrome:

25 (show all 21)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1liver/biliary system phenotypeMP:00053709.9IL2, PTPRC
2respiratory system phenotypeMP:00053889.9PTPRC, DOK1, INPP5D, PTPN6
3limbs/digits/tail phenotypeMP:00053719.1KRAS, NRAS, SRC, PTPN11, FAS, IL10
4skeleton phenotypeMP:00053909.1SRC, PTPRC, PTPN6, PTPN11, TNFSF10, HRAS
5endocrine/exocrine gland phenotypeMP:00053799.0IL2, FASLG, PTPN6, CASP8, CD40LG, KRAS
6renal/urinary system phenotypeMP:00053678.8BCL2, FYN, PTPRC, KRAS, HRAS
7reproductive system phenotypeMP:00053898.8SPP1, SRC, PTPN6, PTPN11, HRAS, IL10
8pigmentation phenotypeMP:00011868.6BCL2, FAS, PTPN11, KRAS, PTPN6, SRC
9digestive/alimentary phenotypeMP:00053818.5NRAS, BCL2, PTPN6, CD4, KRAS, INPP5D
10normal phenotypeMP:00028738.2CD4, CD5, IL10, KRAS, NRAS, PTPRC
11muscle phenotypeMP:00053698.1BCL2, HDAC9, KRAS, SPP1, PTPN11, CASP8
12mortality/agingMP:00107687.5IL2RA, INPP5D, CD4, FYN, XIAP, FAF1
13cardiovascular system phenotypeMP:00053857.5IL10, NRAS, BCL2, KRAS, XIAP, HDAC9
14hematopoietic system phenotypeMP:00053977.1BCL2, SH2D1A, XIAP, FYB, LY9, SLAMF1
15tumorigenesisMP:00020067.1PRF1, INPP5D, HRAS, BCL2, IL2, NRAS
16integument phenotypeMP:00107716.6NRAS, BCL2, XIAP, FYN, CD4, CD40LG
17nervous system phenotypeMP:00036316.5IL10, PRF1, BCL2, CASP8, HRAS, PTPN11
18immune system phenotypeMP:00053876.3PTPN6, PTPN11, DOK1, CASP8, FADD, IL2
19growth/size phenotypeMP:00053786.1HDAC9, FAS, IL2, IL10, INPP5D, IL2RA
20homeostasis/metabolism phenotypeMP:00053765.7PRF1, SLAMF6, FYN, TNFSF10, KRAS, IGHE
21cellular phenotypeMP:00053844.1FASLG, CASP8, TNFSF10, DOK1, PTPN11, PTPN6

Publications for genes affiliated with Lymphoproliferative Syndrome

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35PubMed
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Articles related to lymphoproliferative syndrome:

(show top 50)    (show all 75)
idTitleAuthorsYearAffiliating Genes
1Somatic FAS mutations are common in patients with gen etically undefined autoimmune lymphoproliferative syndrome. (20360470)Dowdell K.C.... Rao V.K.2010FAS
2Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr(-/-) murine model of autoimmune lymphoproliferative syndrome (ALPS). (19217201)Dowdell K.C.... Rao V.K.2009HDAC9, FAS
3FAS-L, IL-10, and double-negative CD4- CD8- TCR alpha/beta+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function. (19176318)Magerus-Chatinet A.... Rieux-Laucat F.2009FASLG, IL10
4Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP). (19595300)Rumble J.M.... Duckett C.S.2009SH2D1A
5Autoimmune lymphoproliferative syndrome (ALPS) caused by Fas (CD95) mutation mimicking sarcoidosis. (18223337)Mullauer L.... Chott A.2008CASP10, FAS
6Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes. (18483205)Bosque A.... Anel A.2008TNFSF10
7The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the FcgammaRIIB receptor. (18662772)Li C.... Li S.S.2008SH2D1A
8Rituximab responsive immune thrombocytopenic purpura in an adult with underlying autoimmune lymphoproliferative syndrome due to a splice-site mutation (IVS7+2 T>C) affecting the Fas gene. (17725802)Wei A.... Cowie T.2007FAS
9Autoimmune lymphoproliferative syndrome (ALPS) in a patient with a new germline Fas gene mutation. (17336828)Del-Rey M.J.... Allende L.M.2007FAS
10Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib. (17605793)Bi L.L.... Straus S.E.2007FAS, FASLG
11Causes and consequences of the autoimmune lymphoproliferative syndrome. (16522544)Rao V.K.... Straus S.E.2006FAS
12XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome. (17080092)Rigaud S.... Latour S.2006XIAP
13A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome. (16627752)Del-Rey M.... Allende L.M.2006FASLG
14Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. (15738056)Pasquier B.... Latour S.2005SH2D1A
15Identical phenotype in patients with somatic and germline CD95 mutations requires a new diagnostic approach to autoimmune lymphoproliferative syndrome. (16291365)RAPssler J.... Ehl S.2005FAS
16Autoimmune lymphoproliferative syndrome with somatic Fas mutations. (15459302)Holzelova E.... Rieux-Laucat F.2004FAS
17Development of lymphoma in Autoimmune Lymphoproliferative Syndrome (ALPS) and its relationship to Fas gene mutations. (15160902)Poppema S.... van den Berg A.2004CASP8, FAS
18Autoimmune lymphoproliferative syndromes: genetic defects of apoptosis pathways. (12655301)Rieux-Laucat F.... Fischer A.2003FAS, FASLG
19FAS gene mutation in a case of autoimmune lymphoproliferative syndrome type IA with accumulation of gammadelta+ T cells. (12657942)van den Berg A.... Poppema S.2003FAS
20Autoimmune lymphoproliferative syndrome: etiology, di agnosis, and management. (12608883)van der Werff ten Bosch J.2003FAS
21Dual functional roles for the X-linked lymphoproliferative syndrome gene product SAP/SH2D1A in signaling through the signaling lymphocyte activation molecule (SLAM) family of immune receptors. (12458214)Li C.... Li S.S.2003FYN, SH2D1A, SLAMF1
22Autoimmune lymphoproliferative syndrome. (12819469)Sneller M.C.... Straus S.E.2003FAS
23Dominant expression of interleukin 10 but not interferon gamma in CD4(-)CD8(-)alphabetaT cells of autoimmune lymphoproliferative syndrome. (12406097)Ohga S.... Hara T.2002IL10
24Inactivation of the Fas gene by Alu insertion: retrotransposition in an intron causing splicing variation and autoimmune lymphoproliferative syndrome. (12215906)Tighe P.J.... Edgar J.D.2002FAS
25Diffuse large B-cell non-Hodgkin's lymphoma in a patient with autoimmune lymphoproliferative syndrome. (11380411)Boulanger E.... Meignin V.2001FAS
26Abnormal T cell receptor signal transduction of CD4 Th cells in X-linked lymphoproliferative syndrome. (11509608)Nakamura H.... Jung J.U.2001SH2D1A
27TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. (11513545)Bleesing J.J.... Fleisher T.A.2001PTPRC, FAS
28The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. (11418480)Straus S.E.... Lenardo M.J.2001FAS
29A genetic disorder of lymphocyte apoptosis involving the fas pathway: the autoimmune lymphoproliferative syndrome. (11895618)Fleisher T.A.... Bleesing J.J.2001FAS
30Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family. (11414741)Lewis J.... Duckett C.S.2001PTPN11, PTPN6, SH2D1A
31Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4. (11099315)Sayos J.... Terhorst C.2000IL2, SH2D1A, SLAMF1
32Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. (10975798)Tangye S.G.... Nichols K.E.2000SH2D1A, SLAMF1
33Description of serologic features in autoimmune lymphoproliferative syndrome. (10960521)Carter L.B.... Cantilena C.C.2000FAS
34Cytomegalovirus infection in infants with autoimmune lymphoproliferative syndrome (ALPS). (10931153)Arkwright P.D.... Cant A.J.2000FAS
35The X-linked lymphoproliferative syndrome gene product SH2D1A associates with p62dok (Dok1) and activates NF-kappa B. (10852966)Sylla B.S.... Kieff E.2000SH2D1A, DOK1
36Reversible monoclonal lymphadenopathy in autoimmune lymphoproliferative syndrome with functional FAS (CD95/APO-1) deficiency. (10403307)StrAPbel P.... Marx A.1999FAS
37Lymphoproliferative syndrome with autoimmunity: A possible genetic basis for dominant expression of the clinical manifestations. (10515860)Rieux-Laucat F.... Le Deist F.1999FAS
38Identification of new Fas mutations in a patient with autoimmune lymphoproliferative syndrome (ALPS) and eosinophilia. (10575548)Aspinall A.I.... Woodman R.C.1999FAS
39Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. (10412980)Wang J.... Lenardo M.J.1999CASP10
40Defective apoptosis due to a point mutation in the death domain of CD95 associated with autoimmune lymphoproliferative syndrome, T-cell lymphoma, and Hodgkin's disease. (10340403)Peters A.M.... Roesler J.1999FAS
41Defective CD95/APO-1/Fas signal complex formation in the human autoimmune lymphoproliferative syndrome, type Ia. (10200300)Martin D.A.... Lenardo M.J.1999FAS
42The use of the anti-malaria drug Fansidar (pyrimethamine and sulphadoxine) in the treatment of a patient with autoimmune lymphoproliferative syndrome and Fas deficiency. (9695976)van der Werff ten Bosch J.E.... Thielemans K.1998FAS
43Human autoimmune lymphoproliferative syndrome, a defect in the apoptosis-inducing Fas receptor: a lesson from the mouse model. (9609991)Nagata S.1998FAS, FASLG
44Missense mutations in the Fas gene resulting in autoimmune lymphoproliferative syndrome: a molecular and immunological analysis. (9028321)Bettinardi A.... Notarangelo L.D.1997FAS
45ALPS: an autoimmune human lymphoproliferative syndrome associated with abnormal lymphocyte apoptosis. (9106310)Puck J.M.... Sneller M.C.1997FAS
46Fas/Apo1 mutations and autoimmune lymphoproliferative syndrome in a patient with type 2 autoimmune hepatitis. (9322534)Pensati L.... Levrero M.1997FAS
47Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. (7539157)Rieux-Laucat F.... de Villartay J.P.1995FAS
48Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. (7540117)Fisher G.H.... Puck J.M.1995FAS
49Usefulness of the immunologic phenotype in the diagnosis of chronic lymphoproliferative syndromes with splenomegaly as the dominant clinical manifestation (2291146)Silva Rodrigues A.... Lopez Borrasca A.1990CD5
50X chromosome-linked lymphoproliferative syndrome (Duncan's disease) (2158858)KrA!l V.... Richter J.1990CD40LG

Expression for genes affiliated with Lymphoproliferative Syndrome

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Expression patterns in normal tissues for genes affiliated with Lymphoproliferative Syndrome

Pathways for genes affiliated with Lymphoproliferative Syndrome

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10EMD Millipore, 41Thomson Reuters, 38Reactome, 37R&D Systems, 20KEGG, 3Cell Signaling Technology, 36QIAGEN
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Pathways related to lymphoproliferative syndrome according to GeneDecks:

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idPathwayScoreTop Affiliating Genes
1Apoptosis and survival Caspase cascade1010.3XIAP, FASLG, FADD, FAS, CASP10, CASP8
2Apoptosis and survival_Caspase cascade4110.3XIAP, FASLG, FAS, CASP10, CASP8, FADD
3Cell surface interactions at the vascular wall389.9CD244, CD84, SRC, INPP5D, KRAS, NRAS
4Development_Flt3 signaling419.8FYN, INPP5D, HRAS, PTPN11
5IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types379.7IL10, IL2, IL2RA, FASLG, FAS
6Development Flt3 signaling109.6SRC, HRAS, FYN, INPP5D, PTPN11
7Apoptosis and survival TNFR1 signaling pathway109.6CASP10, CASP8, FADD, BCL2, XIAP
8Apoptosis and survival_TNFR1 signaling pathway419.5BCL2, XIAP, FADD, CASP10, CASP8
9Chemotaxis_CXCR4 signaling pathway419.5PTPN11, HRAS, PTPRC, DOK1, FYN, SRC
10Chemotaxis CXCR4 signaling pathway109.5SRC, PTPN11, DOK1, HRAS, FYN, PTPRC
11Chagas disease (American trypanosomiasis)209.5IL2, IL10, FADD, FAS, CASP8, FASLG
12Apoptosis and survival_FAS signaling cascades419.5BCL2, XIAP, FASLG, FAS, CASP10, FADD
13Apoptosis and survival FAS signaling cascades109.5CASP8, BCL2, FAS, FADD, FASLG, XIAP
14Lymphocyte Signaling39.4FASLG, CD4, IL2RA, SH2D1A, INPP5D, PTPN6
15Ceramide Pathway369.4BCL2, FADD, NRAS, HRAS, CASP10, CASP8
16Pathways in cancer209.4FAS, NRAS, KRAS, FADD, CASP8, BCL2
17Tyrosine Kinases / Adaptors39.4SH2D1A, FYN, ITK, DOK1, SRC, IL2RA
18Allograft rejection209.4FAS, FASLG, IL2, IL10, CD40LG, PRF1
19Apoptosis Signaling Pathways379.3FAS, XIAP, TNFSF10, CASP8, CASP10, BCL2
20Apoptosis209.3CASP8, CASP10, FAS, FADD, XIAP, FASLG
21Apoptosis through Death Receptors369.2TNFSF10, CASP10, FADD, BCL2, CASP8
22IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types379.2BCL2, IL2, FASLG, IL2RA
23Development EPO-induced Jak-STAT pathway109.1BCL2, XIAP, HRAS, PTPN11, PTPN6, SRC
24Development_EPO-induced Jak-STAT pathway419.1XIAP, SRC, PTPN6, PTPN11, BCL2, HRAS
25TCR Signaling369.0ITK, FYB, FYN, CD4, HRAS, PTPRC
26Apoptosis and survival Apoptotic TNF-family pathways109.0TNFSF10, CASP8, CASP10, FAS, FADD, FASLG
27Apoptosis and survival_Apoptotic TNF-family pathways419.0BCL2, XIAP, CASP8, TNFSF10, CASP10, FAS
28Apoptosis and Autophagy38.9PTPN11, TNFSF10, CASP8, CASP10, FAF1, FASLG
29Autoimmune thyroid disease208.9CD40LG, IL10, IL2, FASLG, FAS, IFNA2
30Tuberculosis208.8FADD, SRC, IL10, BCL2, IFNA2, CASP10
31Innate Immune System388.7CD4, FADD, IFNA2, CASP10, CASP8, BCL2
32PEDF Induced Signaling368.7NRAS, TNFSF10, BCL2, HRAS, IL10, IL2
33Phospholipase-C Pathway368.6SRC, FYN, IL2, IL2RA, HRAS, SPP1
34Development Prolactin receptor signaling108.6FYN, SRC, PTPN11, HRAS, BCL2
35Epithelial Adherens Junctions368.6SRC, NRAS, IL2, PTPN6, FYN, PTPRC
36PAK Pathway368.5CASP10, TNFSF10, HRAS, CASP8, IL10, NRAS
37Measles208.4IL2, IFNA2, SLAMF1, DOK1, TNFSF10, SH2D1A
38Cytokine-cytokine receptor interaction208.4CD27, IL10, IL2, FASLG, IL2RA, TNFSF10
39Development_Prolactin receptor signaling418.4BCL2, SRC, HRAS, FYN, PTPN11
40Endothelin-1 Signaling Pathway368.4SRC, IL2, CASP10, CASP8, BCL2, HRAS
41Natural killer cell mediated cytotoxicity208.4CD244, FYN, SH2D1A, FAS, PRF1, KRAS
42Regulation of eIF4 and p70S6K368.1TNFSF10, NRAS, IL2, BCL2, IL10, CD4
43NFAT Signaling and Lymphocyte Interactions368.1BCL2, IL2RA, IL2, IL10, CD4, TNFSF10
44TGF-Beta Pathway368.1HRAS, IL10, IL2RA, IL2, CD4, NRAS
45Glucocorticoid Receptor Signaling367.9BCL2, HDAC9, TNFSF10, IL2RA, IL2, IL10
46STAT3 Pathway367.9IL2, CD4, IL10, NRAS, IL2RA, BCL2
47T cell receptor signaling pathway207.8ITK, IL2, HRAS, PTPN6, PTPRC, KRAS
48Molecular Mechanisms of Cancer367.7BCL2, IL2, FYN, CD4, FADD, CASP8
49JAK-STAT Pathway367.6TNFSF10, BCL2, IFNA2, CD4, IL10, NRAS
50p38 Signaling367.5NRAS, BCL2, SRC, TNFSF10, HRAS, CD4

Compounds for genes affiliated with Lymphoproliferative Syndrome

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32Novoseek , 42Tocris Bioscience, 34PharmGKB, 9DrugBank, 18HMDB
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Compounds related to lymphoproliferative syndrome according to GeneDecks:

(show top 50)    (show all 181)
idCompoundScoreTop Affiliating Genes
1mitomycin c32 10.3FAS, FADD, FASLG, XIAP, CASP8
2estrogen32 10.3TOLLIP, IGHE, HRAS
3ionomycin32 10.2PTPRC, FYN
4rottlerin32 42 10.8TNFSF10, CASP8, CD40LG, XIAP
5h2o232 9.8FYN, IL2RA, PTPN6, PTPRC, PTPN11
6n acetylcysteine32 9.7IL2RA, PTPRC, TNFSF10, HDAC9, SRC, IGHE
7agar32 9.7CD40LG, HRAS, HDAC9, XIAP, NRAS, SRC
8aspartate32 9.7SRC, CD40LG, TOLLIP, FASLG, HRAS
9rapamycin32 42 10.7HRAS, SRC, IL2, KRAS
10inositol32 9.7SRC, INPP5J, INPP5D, PTPN11, SH2D1A, PTPN6
11mg 13232 42 10.4HDAC9, PTPN6, TNFSF10, FASLG, XIAP, FAS
12pge232 9.4CD4, FASLG, SPP1
13ly29400232 9.3HDAC9, TOLLIP, KRAS, SPP1, SRC, PTPN11
14suberoylanilide hydroxamic acid32 9.1XIAP, BCL2, FASLG, FAS, CASP8, TNFSF10
15noxa32 9.1XIAP, FAS, HDAC9, TNFSF10, CASP8, BCL2
16sb 20358032 42 10.1SPP1, CASP8, HDAC9, BCL2, PTPN11, SRC
17ifn-alpha32 8.9TNFSF10, IFNA2, PTPN11, CASP8, IL2, IL10
18gemcitabine32 34 9 9 11.8BCL2, IL10, CASP8, HRAS, TNFSF10, SRC
19resveratrol32 9 18 9 11.7HDAC9, SRC, TNFSF10, BCL2, XIAP, FASLG
20thalidomide32 42 9 9 11.6IFNA2, FASLG, HDAC9, IL2, IL10, CD40LG
21imatinib32 34 9 9 11.6TNFSF10, CASP8, PTPN11, SRC, KRAS, HDAC9
222-chlorodeoxyadenosine32 8.5FASLG, XIAP, IL2, IL2RA, FAS, CASP8
23paclitaxel32 34 9 9 11.5CASP10, SRC, TNFSF10, HRAS, KRAS, CASP8
24bortezomib32 9 9 10.5CD40LG, BCL2, XIAP, FASLG, CASP8, TNFSF10
25phosphoinositide32 8.4FYN, INPP5D, INPP5J, CD244, TOLLIP, KRAS
26etoposide32 42 9 9 11.4FASLG, CASP8, IFNA2, FAS, FAF1, HDAC9
27wortmannin32 42 9.4PTPN11, FAS, CASP8, INPP5D, FASLG, HRAS
28vegf32 8.4KRAS, SPP1, SRC, HRAS, CD40LG, FYN
29cytarabine32 34 9 9 11.3XIAP, FASLG, FAS, TNFSF10, IFNA2, PTPN6
30fludarabine32 9 9 10.3CD40LG, TNFSF10, XIAP, BCL2, HDAC9, FASLG
31indomethacin32 9 9 10.2IGHE, SPP1, SRC, TNFSF10, IFNA2, FAS
32paraffin32 8.1CD5, FAS, BCL2, XIAP, CD40LG, KRAS
33rituximab32 34 9 9 10.9IFNA2, TNFSF10, XIAP, FASLG, IL2RA, IL2
34actinomycin d32 7.8TNFSF10, FASLG, SPP1, BCL2, XIAP, CD40LG
35phosphotyrosine32 7.8SRC, SLAMF1, PTPRC, PTPN6, PTPN11, DOK1
36cyclosporin a32 42 8.8FYN, SPP1, IL2, HRAS, IL10, ITK
37doxorubicin32 34 9 9 10.7BCL2, XIAP, CD40LG, IL2RA, HDAC9, TNFSF10
38herbimycin a32 42 8.6SPP1, SRC, PTPRC, PTPN6, PTPN11, HRAS
395fluorouracil32 7.5FAS, FADD, BCL2, XIAP, IL2, IL2RA
40oligonucleotide32 7.4FASLG, FADD, FAS, HRAS, PTPN11, SPP1
41cysteine32 7.4XIAP, FYN, CD27, CD4, CD40LG, FASLG
42dexamethasone32 42 34 9 9 11.1CD40LG, IL10, BCL2, XIAP, IL2, TNFSF10
43cycloheximide32 7.0FADD, FASLG, IL2, IL10, XIAP, CD4
44lipid32 7.0INPP5J, CD244, FYN, INPP5D, CD4, XIAP
45retinoic acid32 42 18 8.7KRAS, FAS, FASLG, CD40LG, FYN, IGHE
46cisplatin32 34 9 9 9.7HRAS, CASP8, IFNA2, FAS, FADD, FASLG
47genistein32 9 18 9 9.6SPP1, SRC, PTPRC, PTPN6, TNFSF10, BCL2
48phosphatidylinositol32 5.9HDAC9, TOLLIP, KRAS, SPP1, SRC, PTPRC
49serine32 5.0FAS, FADD, FASLG, IL2, INPP5D, ITK
50tyrosine32 4.0SLAMF6, SLAMF1, TOLLIP, KRAS, NRAS, SPP1

GO Terms for genes affiliated with Lymphoproliferative Syndrome

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Sources:
12Gene Ontology
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Cellular components related to lymphoproliferative syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CD95 death-inducing signaling complexGO:03126510.0CASP8, FAS, FAF1, FADD
2death-inducing signaling complexGO:0312649.9CASP8, FAS, FADD
3membrane raftGO:0451219.2FAS, FADD, CASP8, PTPRC, KRAS, CD4
4external side of plasma membraneGO:0098978.5CD5, CD27, CD4, SLAMF1, PTPRC, FAS
5plasma membraneGO:0058866.6CASP10, CD5, CD40LG, CD84, CD244, CD4
6cytosolGO:0058295.8INPP5J, TOLLIP, NT5C, SRC, PTPN6, FYN

Biological processes related to lymphoproliferative syndrome according to GeneDecks:

(show all 44)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.5FASLG, FAS
2induction of apoptosis via death domain receptorsGO:00862510.4FAS, FADD, FASLG
3positive regulation of Rac protein signal transductionGO:03502210.4KRAS, NRAS, HRAS
4regulation of synaptic transmission, GABAergicGO:03222810.4HRAS, KRAS, NRAS
5striated muscle cell differentiationGO:05114610.4NRAS, KRAS, HRAS
6necrotic cell deathGO:07026510.3FASLG, FADD
7activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691910.2FAS, FASLG, FADD, TNFSF10, CASP8
8immunoglobulin mediated immune responseGO:01606410.2INPP5D, LY9, CD27
9regulation of long-term neuronal synaptic plasticityGO:04816910.2KRAS, NRAS, HRAS
10positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312310.1TNFSF10, CASP10, FADD, FASLG, CASP8
11visual learningGO:00854210.0NRAS, HRAS, KRAS
12B cell differentiationGO:03018310.0IL10, PTPRC, CD40LG, HDAC9
13fibroblast growth factor receptor signaling pathwayGO:00854310.0SRC, HRAS, KRAS, NRAS, PTPN11
14epidermal growth factor receptor signaling pathwayGO:0071739.9SRC, NRAS, PTPN11, KRAS, HRAS
15Ras protein signal transductionGO:0072659.9HRAS, NRAS, KRAS, SRC, DOK1
16insulin receptor signaling pathwayGO:0082869.9PTPN11, KRAS, HRAS, NRAS, DOK1
17induction of apoptosis by extracellular signalsGO:0086249.9FADD, TNFSF10, CASP8, CASP10, FAS, FASLG
18positive regulation of apoptotic processGO:0430659.9PTPRC, FASLG, INPP5D, FAF1, FAS, TNFSF10
19induction of apoptosis by intracellular signalsGO:0086299.6XIAP, BCL2, HRAS, CASP8
20induction of apoptosisGO:0069179.6FAS, TNFSF10, CASP10, IFNA2, FASLG, CD27
21regulation of type I interferon-mediated signaling pathwayGO:0603389.6PTPN11, IFNA2, PTPN6
22defense response to virusGO:0516079.5PRF1, BCL2, FADD, PTPRC
23activation of pro-apoptotic gene productsGO:0086339.5BCL2, FADD, FAS, CASP8, TNFSF10, FASLG
24axon guidanceGO:0074119.5PTPN11, FYN, PTPRC, SRC, KRAS, HRAS
25B cell proliferationGO:0421009.4PTPRC, BCL2, CD40LG, IL10
26T cell differentiationGO:0302179.4CD4, PTPRC, IL2
27negative regulation of neuron apoptotic processGO:0435249.3BCL2, NRAS, KRAS, HRAS
28inflammatory responseGO:0069549.2CD40LG, IL10, IFNA2, TOLLIP, HDAC9, SPP1
29T cell receptor signaling pathwayGO:0508529.2CD4, ITK, PTPRC, FYN, INPP5D, FYB
30positive regulation of cell proliferationGO:0082849.2IL2, SLAMF1, HRAS, KRAS, FASLG, PTPN6
31cell-cell signalingGO:0072679.1SH2D1A, IL10, IL2, TOLLIP, TNFSF10, IFNA2
32B cell receptor signaling pathwayGO:0508539.1PTPRC, BCL2, PTPN6
33response to ethanolGO:0454719.1CD27, CASP8, PRF1, FYN, BCL2
34T cell costimulationGO:0312959.0PTPN11, CD5, FYN, PTPN6, SRC, CD4
35intracellular protein kinase cascadeGO:0072438.9FYN, SRC, DOK1, FYB
36cell surface receptor signaling pathwayGO:0071668.9CD27, PTPRC, DOK1, HRAS, IFNA2, IL2RA
37positive regulation of B cell proliferationGO:0308908.9IL2, CD40LG, BCL2, PTPRC
38leukocyte migrationGO:0509008.8NRAS, PTPN11, FYN, KRAS, SRC, PTPN6
39immune responseGO:0069558.6FASLG, TNFSF10, IL2RA, IGHE, FYB, IL2
40innate immune responseGO:0450878.6CASP10, CD4, FADD, IFNA2, CASP8, TOLLIP
41signal transductionGO:0071658.4TOLLIP, FAS, INPP5D, ITK, CD244, CD4
42anti-apoptosisGO:0069168.4IL10, IL2, FAS, CD27, XIAP, BCL2
43blood coagulationGO:0075968.4SRC, CD244, INPP5D, IFNA2, HRAS, PTPN6
44apoptotic processGO:0069158.1HRAS, BCL2, FADD, FAS, FASLG, IL2RA

Molecular functions related to lymphoproliferative syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:0051649.5CD40LG, FASLG, TNFSF10, FADD, CASP8
2receptor activityGO:0048728.8CD4, LY9, FAS, CD5, CD84, CD244
3cytokine activityGO:0051258.1CD40LG, IL10, IL2, FASLG, TNFSF10, SPP1
4protein bindingGO:0055153.9HDAC9, IFNA2, FAS, FADD, FASLG, INPP5D

Sources for Lymphoproliferative Syndrome

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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