Lymphosarcoma malady

Wikipedia: Lymphoma is a cancer of the lymphocytes, a type of cell that forms part of the immune system. Typically,...⁴⁴ more...

MalaCards: Lymphosarcoma, also known as malignant lymphoma (category), is related to b-cell lymphomas and mantle cell lymphoma. An important gene associated with Lymphosarcoma is MYB (v-myb myeloblastosis viral oncogene homolog (avian)), and among its related pathways are Selected targets of Oct-3/4 and Cysteine and methionine metabolism. The drugs doxorubicin hydrochloride and irinotecan hydrochloride and the compounds rapamycin and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and brain, and related mouse phenotypes are respiratory system and liver/biliary system.

Aliases & Descriptions:

lymphosarcoma 6 30 8 32 malignant lymphoma (category) 6 lymphoma, diffuse 43

diffuse lymphoma 6 lymphoma 43

Diseases related to lymphosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 499)

id	Related Disease	Score	Top Affiliating Genes
1	b-cell lymphomas	38.7	BMI1, BCL2, BCL6, CD22, IGH@, TNFRSF8
2	mantle cell lymphoma	37.5	BMI1, BCL2, BCL6
3	cutaneous t cell lymphoma	36.2	MYB, IL2RA, TNFRSF8
4	anaplastic large cell lymphoma	35.2	BCL2, BCL6, LGALS1, IL10, IL2RA, TNFRSF8
5	diffuse large b-cell lymphoma	34.9	BCL2, BCL6, LGALS1, IL10, IL2RA, MBL2
6	burkitt's lymphoma	34.9	MYB, BMI1, BCL2, BCL6, LGALS1, IL10
7	follicular lymphoma	34.8	BCL2, BCL6, IL10, IL2RA, MBL2, IGH@
8	peripheral t-cell lymphoma	34.2	BCL6, IL2RA, TNFRSF8, PTPRC
9	lymphoblastic lymphoma	33.7	BCL2, BCL6, IGH@, TNFRSF8, PTPRC
10	gastric lymphoma	33.6	BCL2, BCL6, IGH@
11	t-cell leukemia	33.2	MYB, BCL2, LGALS1, IL2RA, IGH@, ERVW-1
12	primary effusion lymphoma	32.8	MYB, BCL2, BCL6, IL10, IGH@, PTPRC
13	b-cell non-hodgkin lymphoma	32.6	BMI1, BCL2, BCL6, IL10, IL2RA, IGH@
14	mediastinitis	32.6	MYB, BCL6, IL2RA, TNFRSF8, PTPRC
15	central nervous system lymphoma	32.5	BCL2, BCL6, LGALS1, IL10, IGH@, PTPRC
16	adult t-cell leukemia	32.1	BCL2, LDHA, IL10, IL2RA, IGH@, ERVW-1
17	leukemia/lymphoma, t-cell	32.0	BCL2, IL2RA, TNFRSF8, PTPRC, ABL1
18	intraocular lymphoma	32.0	BCL2, BCL6, IL10
19	hepatitis	31.5	GSR, DNMT3A, DNMT1
20	leukemia/lymphoma	31.2	BCL2, BCL6, LGALS1, LDHA, IL10, IL2RA
21	mycosis fungoides	30.5	BMI1, BCL2, IL10, IL2RA, TNFRSF8
22	lymphoma, diffuse large cell	30.2	BCL2, BCL6, TNFRSF8, PTPRC
23	acute lymphoblastic leukemia	29.9	MYB, BCL2, BCL6, CD22, IGH@, PTPRC
24	neutropenia	29.8	BCL2, IL10, MBL2, DCTD
25	hairy cell leukemia	29.7	BCL6, IL2RA, PTPRC
26	hepatitis c	29.6	BCL6, GSR, IL10, PTPRC
27	reticulosarcoma	29.3	BCL2, BCL6, IGH@, TNFRSF8, PTPRC
28	chronic lymphocytic leukemia	29.1	MYB, BCL2, BCL6, CD22, GSR, IL10
29	acquired immunodeficiency syndrome	29.0	BCL2, BCL6, IL10, IL2RA, PTPRC, NR3C1
30	ataxia telangiectasia	29.0	BCL2, BCL6, ABL1, DNMT1
31	waldenstrom macroglobulinemia	28.6	BCL2, IL10, IGH@, PTPRC
32	lymphocytic leukemia	28.4	MYB, BCL2, BCL6, CD22, GSR, IL10
33	histiocytosis	28.3	MYB, IL10, TNFRSF8, PTPRC
34	kaposi's sarcoma	28.0	BCL2, BCL6, IL10, TNFRSF8, PTPRC, NR3C1
35	eosinophilia	28.0	IL10, IL2RA, MBL2, ABL1
36	macroglobulinemia	28.0	BCL2, CD22, IL10, IGH@, PTPRC
37	immunodeficiency	27.8	MYB, BCL2, BCL6, IL10, IL2RA, MBL2
38	autoimmune lymphoproliferative syndrome	27.8	IL10, IL2RA, PTPRC
39	acute leukemia	27.8	MYB, BMI1, BCL2, CD22, GSR, IGH@
40	combined immunodeficiency	27.7	BCL2, BCL6, IL10, IL2RA, TNFRSF8, PTPRC
41	severe combined immunodeficiency	27.7	BCL2, BCL6, IL10, IL2RA, TNFRSF8, PTPRC
42	plasmacytoma	27.6	BCL2, BCL6, IGH@, TNFRSF8, PTPRC
43	lymphoproliferative syndrome	27.6	BCL2, IL10, IL2RA, PTPRC
44	myelodysplastic syndrome	27.3	MYB, BMI1, BCL2, BCL6, ABL1, DNMT3A
45	lymphoepithelioma-like carcinoma	27.3	BCL2, TNFRSF8, PTPRC
46	multiple myeloma	27.2	BMI1, BCL2, BCL6, IL10, IL2RA, MBL2
47	thrombosis	27.2	LGALS1, MTF1, ASRGL1, IL10, MBL2
48	myeloma	27.2	BMI1, BCL2, BCL6, LGALS1, IL10, IL2RA
49	human t-cell leukemia virus type 1	27.2	MYB, BCL2, IL2RA, MBL2, ERVW-1, PTPRC
50	retinoblastoma	27.1	MYB, BMI1, BCL2, LGALS1, LDHA, PTPRC

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 asparaginase, cytarabine, cytarabine liposome, doxorubicin hydrochloride, irinotecan, irinotecan hydrochloride, mitoxantrone, mitoxantrone hydrochloride, thiotepa

MalaCards organs/tissues related to lymphosarcoma:

²²

MGI Mouse Phenotypes related to lymphosarcoma:

²⁵ (show all 12)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	9.4	SMARCA4, PTPRC, LDHA, BCL6
2	liver/biliary system phenotype	MP:0005370	8.3	AGAP2, ABL1, SMARCA4, PTPRC, MTF1, BCL6
3	hematopoietic system phenotype	MP:0005397	8.2	BMI1, DNMT1, ABL1, PTPRC, CD22, MTF1
4	tumorigenesis	MP:0002006	8.2	DNMT1, SMARCA4, PTPRC, IL10, MTF1, LDHA
5	immune system phenotype	MP:0005387	6.7	DNMT1, ABL1, SMARCA4, NR3C1, PTPRC, TNFRSF8
6	normal phenotype	MP:0002873	6.6	DNMT1, ABL1, NR3C1, PTPRC, IL10, GSR
7	digestive/alimentary phenotype	MP:0005381	6.6	DNMT1, ABL1, SMARCA4, NR3C1, PTPRC, IL2RA
8	mortality/aging	MP:0010768	6.5	DNMT1, DNMT3A, ABL1, SMARCA4, NR3C1, IL2RA
9	cardiovascular system phenotype	MP:0005385	6.4	ABL1, SMARCA4, NR3C1, IL10, GSR, MTF1
10	growth/size phenotype	MP:0005378	6.0	PTPRC, NR3C1, ABL1, AGAP2, DNMT3A, IL2RA
11	homeostasis/metabolism phenotype	MP:0005376	5.8	SMARCA4, ABL1, H6PD, AGAP2, DNMT3A, DNMT1
12	cellular phenotype	MP:0005384	5.6	PTPRC, NR3C1, SMARCA4, ABL1, DNMT3A, DNMT1

Articles related to lymphosarcoma:

id	Title	Authors	Year	Affiliating Genes
1	The state of enzymatic redox system of glutathione i n the blood of patients with lymphosarcoma (non-Hodgkin's lymphoma (19642581)	Gavriliuk L.A.... LysyA- L.T.	2009	GSR, H6PD
2	Physical and functional interaction of DNA methyltran sferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. (16322236)	Datta J.... Jacob S.T.	2005	DNMT3A, SMARCA4
3	Differential diagnostic and prognostic value of serum cytokines (soluble CD30, soluble interleukin-2 receptor, interleukin-10 and interleukin-6) in Hodgkin's disease and lymphosarcomas (11494447)	Iaguzhinskaia O.E.... Pivnik A.V.	2001	IL2RA, IL10, TNFRSF8
4	A novel truncated env gene isolated from a feline leukemia virus-induced thymic lymphosarcoma. (10627556)	Shi Y.... Roy-Burman P.	2000	ERVW-1
5	Are matrix-immobilized neoglycoproteins, plant and human lectins and carbohydrate--binding antibodies from human serum mediators of adhesion in vitro for carcinoma and lymphosarcoma cells? (7733629)	Wawotzny R.... Gabius H.J.	1995	MBL2, LGALS1
6	flvi-2, a target of retroviral insertional mutagenesis in feline thymic lymphosarcomas, encodes bmi-1. (8390036)	Levy L.S.... Overbaugh J.	1993	BMI1
7	Specific expression of cellular oncogenes c-myc and c-myb in T-cell lines established from three types of bovine lymphosarcomas. (8116930)	Ishiguro N.... Shinagawa M.	1993	ABL1, LDHA, MYB
8	The morphoimmunological correlates in the leukemic d egeneration of prolymphocytic lymphosarcoma (8032777)	Frenkel' M.A.... Solov'eva E.A.	1993	CD22
9	Effect of sodium butyrate on glucocorticoid-sensitive and -resistant P1798 lymphosarcoma. (1312378)	Chang Y.F.... Chi C.W.	1992	NR3C1
10	T-cell lymphosarcoma in a female African green monkey (Cercopithecus aethiops). (2153857)	Jayo M.J.... Reynolds G.M.	1990	PTPRC

Genes related to lymphosarcoma according to GeneCards:

(show all 26)

id	Symbol	Description	Score	GeneCards Section Context
1	MYB	v-myb myeloblastosis viral oncogene homolog (avian)	11.0	Publications
2	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0	Publications
3	IGH@	immunoglobulin heavy locus	11.0
4	BCL6	B-cell CLL/lymphoma 6	11.0
5	DNMT1	DNA (cytosine-5-)-methyltransferase 1	11.0
6	BCL2	B-cell CLL/lymphoma 2	11.0
7	CD8BP	CD8b molecule pseudogene	11.0	Disorders
8	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	11.0
9	LDHA	lactate dehydrogenase A	11.0	Publications
10	DCTD	dCMP deaminase	11.0
11	BMI1	BMI1 polycomb ring finger oncogene	11.0	Publications
12	CD22	CD22 molecule	11.0	Publications
13	ASRGL1	asparaginase like 1	11.0
14	H6PD	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	11.0	Publications
15	ERVW-1	endogenous retrovirus group W, member 1	11.0	Publications
16	MTF1	metal-regulatory transcription factor 1	11.0
17	LGALS1	lectin, galactoside-binding, soluble, 1	11.0	Publications
18	DNMT3A	DNA (cytosine-5-)-methyltransferase 3 alpha	11.0	Publications
19	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	11.0	Publications
20	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
21	GSR	glutathione reductase	11.0	Publications
22	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
23	NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	11.0	Publications
24	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
25	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	11.0	Publications
26	IL10	interleukin 10	11.0	Publications

Pathways related to lymphosarcoma according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of Oct-3/410	9.8	BMI1, DNMT3A, DNMT1
2	Cysteine and methionine metabolism20	9.7	LDHA, DNMT3A, DNMT1
3	Immune response BCR pathway10	9.7	PTPRC, IGH@, CD22, BCL6
4	Immune response_BCR pathway41	9.6	BCL6, CD22, IGH@, PTPRC
5	Lymphocyte Signaling3	9.3	BMI1, BCL6, LGALS1, IL2RA
6	Chromatin Regulation / Acetylation3	9.1	DNMT1, DNMT3A, SMARCA4, BMI1
7	Glucocorticoid Receptor Signaling36	8.3	SMARCA4, NR3C1, IL2RA, IL10, BCL2

Compounds related to lymphosarcoma according to GeneDecks:

(show top 50)    (show all 61)

id	Compound	Score	Top Affiliating Genes
1	rapamycin32 42	11.4	MYB, LGALS1
2	cyclophosphamide32 34 9 9	13.3	MBL2, BCL6
3	zebularine32 42	11.2	DCTD, DNMT1, DNMT3A
4	5-azacytidine42	10.1	DNMT1, DNMT3A
5	o-ethylhydroxylamine32	10.1	GSR, H6PD
6	rg 10842	10.0	DNMT1, DNMT3A
7	dmso32	10.0	ABL1
8	no-dimethylhydroxylamine32	9.8	H6PD, GSR
9	2-chlorodeoxyadenosine32	9.7	DCTD, DNMT1, IL2RA, BCL2
10	swainsonine32 42 9 9	12.5	PTPRC, IL2RA, LGALS1
11	cortisone32 18	10.5	H6PD, NR3C1, IL10
12	retinoid32	9.4	DNMT1, NR3C1, LGALS1, BCL2, MYB
13	cysteine32	9.4	DNMT1, H6PD, SMARCA4, MTF1, LGALS1, MYB
14	cadmium32 18	10.4	DNMT1, SMARCA4, IL2RA, MTF1
15	glyceraldehyde 3-phosphate32	9.4	LGALS1, LDHA, GSR, ERVW-1, H6PD
16	butyrate32	9.3	DNMT1, NR3C1, LGALS1, BCL2, MYB
17	rituximab32 34 9 9	12.3	BCL2, BCL6, IL10, IL2RA
18	estrogen32	9.3	DNMT1, SMARCA4, NR3C1, GSR, BMI1
19	agarose32	9.2	PTPRC, IGH@, MBL2, LDHA, LGALS1, BCL2
20	h2o232	9.2	H6PD, PTPRC, IL2RA, MTF1, MYB
21	tuberculin32	9.2	IL10, IL2RA, MBL2, TNFRSF8
22	agar32	9.1	ABL1, SMARCA4, ERVW-1, LGALS1
23	azathioprine32 34 9 9	12.1	IL10, IL2RA, DNMT3A, DNMT1
24	sialic acid32	9.1	LGALS1, CD22, MBL2, PTPRC
25	methionine32	9.1	DNMT1, PTPRC, ERVW-1, LGALS1, MYB
26	folate32	9.0	DNMT1, DNMT3A, H6PD, IL2RA, GSR
27	con a32	9.0	MBL2, IL2RA, IL10, LGALS1
28	imatinib32 34 9 9	11.9	DNMT1, ABL1, IL10, BCL6, BCL2, MYB
29	thymidine32 18	9.9	DCTD, DNMT1, TNFRSF8, IL2RA, IL10, MYB
30	doxorubicin32 34 9 9	11.7	DNMT1, NR3C1, IL2RA, GSR, BCL6, BCL2
31	prednisolone32 9 9	10.6	IL10, IL2RA, MBL2, NR3C1
32	cycloheximide32	8.5	DNMT1, NR3C1, PTPRC, IL10, MTF1, BCL6
33	aspartate32	8.4	GSR, MBL2, NR3C1, ABL1
34	polysaccharide32	8.4	H6PD, PTPRC, ERVW-1, MBL2, IL2RA, CD22
35	hydrogen32 18	9.4	DNMT1, H6PD, ABL1, PTPRC, ERVW-1, MBL2
36	oligonucleotide32	8.2	DNMT1, DNMT3A, ABL1, SMARCA4, ERVW-1, IGH@
37	adenylate32	8.2	DNMT1, H6PD, ABL1, IL2RA, GSR, ASRGL1
38	paraffin32	8.1	PTPRC, TNFRSF8, MBL2, IL2RA, IL10, LGALS1
39	steroid32	8.1	MYB, IL2RA, MBL2, ERVW-1, NR3C1, SMARCA4
40	cisplatin32 34 9 9	11.0	DNMT1, ABL1, NR3C1, IL2RA, GSR, BCL2
41	superoxide32 18	8.9	H6PD, ABL1, PTPRC, MBL2, GSR, MTF1
42	vitamin d32	7.9	DNMT1, NR3C1, MBL2, IL2RA, IL10
43	progesterone32 42 9 18 9	11.8	DNMT1, ABL1, SMARCA4, NR3C1, PTPRC, MBL2
44	dexamethasone32 42 34 9 9	11.7	NR3C1, PTPRC, MBL2, IL2RA, IL10, LGALS1
45	oxygen32 18	8.4	DNMT1, H6PD, ABL1, ERVW-1, MBL2, GSR
46	lipid32	7.3	GSR, MBL2, ERVW-1, TNFRSF8, PTPRC, SMARCA4
47	vegf32	7.2	DNMT1, ABL1, NR3C1, MBL2, IL2RA, IL10
48	serine32	7.0	TNFRSF8, PTPRC, NR3C1, ABL1, DNMT1, ERVW-1
49	zinc32 18	7.7	MYB, DNMT1, DNMT3A, H6PD, ABL1, SMARCA4
50	tyrosine32	6.4	ERVW-1, TNFRSF8, PTPRC, SMARCA4, ABL1, DNMT1

Cellular components related to lymphosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	replication fork	GO:005657	10.1	BCL6, DNMT1

Biological processes related to lymphosarcoma according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of B cell proliferation	GO:030890	9.9	BCL2, BCL6, PTPRC
2	type 2 immune response	GO:042092	9.8	BCL6, IL10
3	methylation-dependent chromatin silencing	GO:006346	9.7	SMARCA4, DNMT3A
4	B cell proliferation	GO:042100	9.6	BCL2, IL10, PTPRC
5	B cell differentiation	GO:030183	9.5	PTPRC, IL10, BCL6
6	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.2	DNMT1, DNMT3A, SMARCA4, BCL6, BMI1, MYB
7	positive regulation of apoptotic process	GO:043065	9.0	BCL6, TNFRSF8, PTPRC, ABL1
8	response to insulin stimulus	GO:032868	9.0	NR3C1, IL10, BCL2

Molecular functions related to lymphosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	DNA (cytosine-5-)-methyltransferase activity	GO:003886	10.0	DNMT3A, DNMT1