MCID: LYM019
MIFTS: 54

Lymphosarcoma malady

Immune diseases category

Summaries for Lymphosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphoma is a type of blood cancer that occurs when B or T lymphocytes, the white blood cells that form... more...

MalaCards: Lymphosarcoma, also known as malignant lymphoma, is related to leukemia and central nervous system lymphoma. An important gene associated with Lymphosarcoma is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are Selected targets of Oct-3/4 and Validated targets of C-MYC transcriptional repression. The compounds butyrate and zebularine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and spleen, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Classifications for Lymphosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

lymphosarcoma 8 42 10 44
malignant lymphoma 8
lymphoma, diffuse 60
diffuse lymphoma 8


External Ids:

Disease Ontology8 DOID:8675
NCIt39 C26919
MeSH34 D008228
ICD9CM27 200.1

Related Diseases for Lymphosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Lymphosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 310)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0DNMT1, MYB, IGH, DCTD, BMI1, MBL2
2central nervous system lymphoma30.7BCL6
3reticulosarcoma30.5BCL6, TNFRSF8
4anaplastic large cell lymphoma30.4TNFRSF8, BCL6
5gastric lymphoma30.4IGH, BCL6
6malignant histiocytosis30.3MYB, TNFRSF8
7hepatitis30.3DNMT1, DNMT3A, GSR
8acute leukemia30.3BMI1, IGH, MYB, DNMT1, CD22, GSR
9mantle cell lymphoma30.2BMI1, BCL6, BCL2
10myeloma30.2TNFRSF8, IGH, LGALS1, BCL6, BCL2
11hepatitis c30.1GSR, ERVW-1, MYB
12hodgkin's lymphoma30.1TNFRSF8, BMI1, IGH, LGALS1, BCL6, BCL2
13lymphoma, diffuse large cell30.1BCL2, BCL6, TNFRSF8
14burkitt's lymphoma30.0TNFRSF8, BCL6, BCL2
15systemic lupus erythematosus30.0CD22
16rheumatoid arthritis30.0MBL2, TNFRSF8, MYB, ERVW-1, LGALS1
17non-hodgkin lymphoma30.0TNFRSF8, BMI1, IGH, MYB, BCL6, BCL2
18pneumonia30.0MBL2
19plasmacytoma30.0BCL6, IGH, TNFRSF8
20t-cell leukemia30.0TNFRSF8, IGH, MYB, ERVW-1, LGALS1, BCL2
21b-cell chronic lymphocytic leukemia29.8BCL2, IGH
22hepatitis b29.8MBL2, TNFRSF8, MYB, DNMT1, GSR
23retinoblastoma29.8BMI1, MYB, DNMT1, BCL2, SMARCA4
24lung cancer29.8SMARCA4, BCL2, LGALS1, DNMT1
25breast cancer29.8BMI1, DNMT1, ERVW-1, LGALS1, BCL2
26adenoma29.8TNFRSF8, DNMT1, LGALS1, BCL2, SMARCA4, GSR
27sarcoma29.7LGALS1, ERVW-1
28pancreatitis29.7ASRGL1, H6PD
29thyroiditis29.7MBL2
30stomach cancer29.7BCL2, DNMT1, MBL2
31myeloid leukemia29.7BMI1, MYB, DNMT1, BCL2
32chronic myeloid leukemia29.7BCL2, DNMT1, MYB, BMI1
33chronic lymphocytic leukemia29.7BCL2, BCL6, MYB, IGH
34acute lymphocytic leukemia29.7IGH, MYB, CD22, BCL6, BCL2
35adenocarcinoma29.7MYB, DNMT1, ERVW-1, LGALS1, BCL2, SMARCA4
36melanoma29.7BMI1, MYB, DNMT1, LGALS1, BCL2, SMARCA4
37bone lymphoma10.6
38bladder lymphoma10.5
39thyroid lymphoma10.5
40breast lymphoma10.5
41mediastinal malignant lymphoma10.4
42heart lymphoma10.4
43hypercalcemia10.3
44lung lymphoma10.3
45small intestine lymphoma10.3
46appendix lymphoma10.2
47adult lymphoma10.2
48histiocytosis10.2
49mediastinitis10.2
50rectum lymphoma10.2

Graphical network of the top 20 diseases related to Lymphosarcoma:



Diseases related to lymphosarcoma

Clinical Features for Lymphosarcoma

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Drugs & Therapeutics for Lymphosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lymphosarcoma

Drug clinical trials:

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Search NIH Clinical Center for Lymphosarcoma

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Genetic Tests for Lymphosarcoma

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Anatomical Context for Lymphosarcoma

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32MalaCards
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MalaCards organs/tissues related to Lymphosarcoma:

32
Bone marrow, Bone, Spleen, Lymph node, T cells, Lung, Liver, Colon, B cells, Thyroid, Testes, Spinal cord, Brain, Skin, Thymus, Heart, Tongue, Myeloid, Cervix, Uterus, Breast, Trachea, Skeletal muscle

Animal Models for Lymphosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.8MTF1, MYB, DNMT1, DNMT3A, CD22, BCL6
2MP:00053978.2MTF1, BMI1, TNFRSF8, MBL2, MYB, DNMT1
3MP:00053878.1SMARCA4, MBL2, TNFRSF8, BMI1, MTF1, MYB

Publications for Lymphosarcoma

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50PubMed
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Articles related to Lymphosarcoma:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Feline small cell lymphosarcoma versus inflammatory bowel disease: treatment and prognosis. (23814916)
2013
2
Lymphosarcoma in a captive bonnethead shark, Sphyrna tiburo (L.). (23121332)
2013
3
A Bovine Lymphosarcoma Cell Line Infected with Theileria annulata Exhibits an Irreversible Reconfiguration of Host Cell Gene Expression. (23840536)
2013
4
Cyclophosphamide metabolite inducing apoptosis in RLS mouse lymphosarcoma cells is a substrate for P-glycoprotein. (22803083)
2012
5
Multicentric T-cell lymphosarcoma in a white-tailed deer (Odocoileus virginianus). (19617490)
2009
6
Hypernatremia and hyperlipidemia in a dog with central nervous system lymphosarcoma. (16955835)
2006
7
Ultrasound-guided biopsy as a diagnostic aid in three horses with a cranial mediastinal lymphosarcoma. (15214516)
2004
8
Lymphosarcoma-induced alterations in hepatic adrenergic receptors: implications to the hypoglycemia of cancer cachexia. (12962155)
2003
9
Primary intratracheal lymphosarcoma in four cats. (14518655)
2003
10
Immunohistochemical characterization of lymphosarcoma in two alpacas (Lama pacos). (12354547)
2002
11
Multicentric lymphosarcoma in a dog with multiple-site skeletal involvement. (11245235)
2001
12
Epitheliotropic T-cell gastrointestinal tract lymphosarcoma with metastases to lung and skeletal muscle in a cat. (10687007)
2000
13
Lymphosarcoma with leukemic blood profile in a Savannah monitor lizard (Varanus exanthematicus). (10367659)
1999
14
Clinical and anatomical features of lymphosarcoma in 118 cats. (9862061)
1998
15
Adoptive immunotherapy of murine lymphosarcoma: comparative study using allo-immune or tumor-immune T cells. (9357160)
1997
16
Spontaneous renal lymphosarcoma in a juvenile cynomolgus monkey (Macaca fascicularis). (7932641)
1994
17
Lymphosarcoma in a desert bighorn sheep. (1457563)
1992
18
Thymic and mammary lymphosarcoma in a three-year-old heifer. (1568914)
1992
19
Epididymal swelling attributable to generalized lymphosarcoma in a stallion. (1483916)
1992
20
Partial characterization of a familial B lymphosarcoma with a thymic localization in cattle. (1625488)
1992
21
Protection against metastasis of radiation-induced thymic lymphosarcoma and weight loss in C57Bl/6NCr1BR mice by an autoclave-resistant factor present in soybeans. (1438709)
1992
22
Immunodeficiency associated with lymphosarcoma in a horse. (1500330)
1992
23
Hypercalcaemia and soft tissue mineralisation associated with lymphosarcoma in two horses. (2309415)
1990
24
Lymphosarcoma development in sheep experimentally infected with bovine leukaemia virus. (2552706)
1989
25
Bovine mandibular lymphosarcoma. (2800293)
1989
26
Spontaneous regression of lymphosarcoma in a dog. (3350750)
1988
27
Characterization of metastasis-associated antigens on RAW117 lymphosarcoma cell lines. (3103962)
1987
28
Thymic lymphosarcoma in three heifers. (3793601)
1986
29
Alterations in microsomal drug metabolism and heme oxygenase activity in isolated hepatic parenchymal and sinusoidal cells in Murphy-Sturm lymphosarcoma-bearing rats. (3093126)
1986
30
A monoclonal surface immunoglobulin (IgM/D-L) with specificity for surface antigen of ox red blood cells in a patient with leukemic lymphosarcoma. (3490488)
1986
31
Primary lymphosarcoma of the lung. (3838769)
1985
32
Immune complex glomerulonephritis in a cat with renal lymphosarcoma. (3890347)
1985
33
Reflections on the diagnostic approach to multicentric lymphosarcoma in an aged Arabian mare. (2934248)
1985
34
Multicentric lymphosarcoma with lymphoblastic leukaemia in a young horse. (6591626)
1984
35
Development of lymphosarcoma in sheep after inoculation with bovine leucosis virus. (6093758)
1984
36
Induction of lymphosarcoma in sheep inoculated with bovine leukaemia virus. (6330182)
1984
37
Cutaneous lymphosarcoma and leukemia in a dog resembling SAczary syndrome in man. (6610244)
1984
38
Characterization of cytostatic effector lymphocytes during the development of a syngeneic lymphosarcoma in C3H mice: use of monoclonal reagents to identify T-cell subsets. (6606491)
1983
39
Purification and characterization of Murphy-Sturm lymphosarcoma (MSLS) tumor kininogen. (6687975)
1983
40
Lymphosarcoma with hypercalcemia and osteolysis in a dog. (17422315)
1983
41
Localized chemotherapy of Gardner's lymphosarcoma of C3H mice using combinations of carrier-sorbed antifolics and detoxicating tetrahydrofolates. (6973453)
1981
42
Resistance to androgen in murine lymphosarcoma lines resistant or sensitive to glucocorticoid hormone. (6894859)
1981
43
A possibility of predicting metastatic ability of tumours by implantation into chick embryos. Epigenetic grading of metastasizing and non-metastasizing forms of a hamster lymphosarcoma. (6893184)
1980
44
Radiographic case of the month: Gastric lymphosarcoma. (6929070)
1980
45
Canine lymphosarcoma: a model for study of the hypercalcemia of cancer. (6769560)
1980
46
Case report; primary lymphosarcoma of the breast. (582062)
1979
47
Lymphosarcoma with virus-like particles in a neonatal foal. (224560)
1979
48
Preliminary results of chemoradiotherapy followed (or not ) by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma: correlation of the results with WHO categorization. (370939)
1978
49
Growth of canine lymphosarcoma in X-irradiated and non-irradiated athymic (Nude) mice. (581664)
1978
50
The mechanical resistance of white blood cells in lymphosarcoma, reticulosarcoma and malignant lymphogranuloma: a contribution to the differential diagnosis and to the knowledge of the biologic behaviour of leukocytes in human pathology. (13798549)
1959

Genetic Variations for Lymphosarcoma

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Expression for genes affiliated with Lymphosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphosarcoma

Search GEO for disease gene expression data for Lymphosarcoma.

Pathways for genes affiliated with Lymphosarcoma

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12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Lymphosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DNMT3A, DNMT1, BMI1
29.8DNMT3A, LGALS1, BCL2
39.8BCL2, DNMT3A, DNMT1, BMI1
49.7SMARCA4, DNMT3A, DNMT1, BMI1
59.6BCL6, LGALS1, MYB, BMI1

Compounds for genes affiliated with Lymphosarcoma

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Lymphosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5MYB
2zebularine4410.5DNMT1, DCTD
3cycloheximide4410.5MTF1
4o-ethylhydroxylamine4410.5GSR, H6PD
5estrogen4410.5BCL6, MBL2
6no-dimethylhydroxylamine4410.5GSR, H6PD
73-deazaneplanocin a hydrochloride5910.4DNMT1, DNMT3A
8unc 06465910.4DNMT1, DNMT3A
9unc 06385910.4DNMT1, DNMT3A
10bix 012945910.4DNMT1, DNMT3A
11sgc 09465910.4DNMT1, DNMT3A
122-chlorodeoxyadenosine4410.4DCTD, DNMT1, BCL2
13serine4410.3MTF1, ERVW-1
14dihydrofolate4410.3H6PD, DNMT1, SMARCA4
15cytidine44 11 2412.2BCL6, DNMT1, DCTD
16imatinib44 49 1112.1MYB, DNMT1, BCL6, BCL2
17cadmium44 2411.1MTF1, DNMT1, SMARCA4
18folate4410.1H6PD, DNMT1, DNMT3A, GSR
19cyclophosphamide44 49 1112.0MBL2, BCL6, BCL2, GSR
20retinoid4410.0MYB, DNMT1, LGALS1, BCL2
21cytosine44 2411.0DNMT3A, DNMT1, MYB
22monosaccharide4410.0LGALS1, MBL2
23doxorubicin44 49 1111.9GSR, BCL2, BCL6, DNMT1, MYB
24tuberculin449.9MBL2, TNFRSF8
25galactose449.8H6PD, MBL2, LGALS1
26agarose449.8MBL2, IGH, LGALS1, BCL2
27fructose-1,6-bisphosphate449.8GSR, H6PD
28glyceraldehyde 3-phosphate449.8H6PD, ERVW-1, LGALS1, GSR
29agar449.8DNMT1, ERVW-1, LGALS1, SMARCA4
30progesterone44 59 28 11 2413.7MBL2, MYB, DNMT1, BCL2, SMARCA4
31adenylate449.7H6PD, MYB, DNMT1, ASRGL1, GSR
32methionine449.7LGALS1, ERVW-1, DNMT1, MYB
33superoxide44 2410.7H6PD, MBL2, MTF1, LGALS1, GSR
34paraffin449.7MBL2, TNFRSF8, LGALS1, BCL6, BCL2
35polysaccharide449.7H6PD, MBL2, CD22, ERVW-1, LGALS1
36h2o2449.7GSR, BCL2, MYB, MTF1, H6PD
37steroid449.6H6PD, MBL2, MYB, DNMT1, ERVW-1, SMARCA4
38polyacrylamide449.6H6PD, IGH, ERVW-1, LGALS1
39oxygen44 2410.5MBL2, MTF1, MYB, DNMT1, ERVW-1, LGALS1
40oligonucleotide449.1IGH, MYB, DNMT1, DNMT3A, CD22, ERVW-1
41lipid449.0H6PD, MBL2, TNFRSF8, MYB, ERVW-1, LGALS1
42cysteine448.9H6PD, MBL2, MTF1, MYB, DNMT1, ERVW-1
43tyrosine448.6MBL2, TNFRSF8, MTF1, MYB, DNMT1, CD22
44zinc44 249.6SMARCA4, H6PD, MBL2, TNFRSF8, BMI1, MTF1

GO Terms for genes affiliated with Lymphosarcoma

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16Gene Ontology
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Cellular components related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.1BCL6, DNMT1

Biological processes related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA methylationGO:00630610.1DNMT3A, DNMT1
2DNA methylation on cytosine within a CG sequenceGO:01042410.1SMARCA4, DNMT3A
3positive regulation of histone H3-K4 methylationGO:05157110.1DNMT1, MYB
4methylation-dependent chromatin silencingGO:00634610.1DNMT3A, SMARCA4
5negative regulation of cell growthGO:0303089.5SMARCA4, BCL2, BCL6
6negative regulation of transcription from RNA polymerase II promoterGO:0001229.4SMARCA4, BCL6, DNMT3A, DNMT1, MYB, BMI1

Molecular functions related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA (cytosine-5-)-methyltransferase activityGO:00388610.0DNMT3A, DNMT1
2chromatin bindingGO:0036829.3MYB, DNMT3A, BCL6, SMARCA4
3protein bindingGO:0055158.0BMI1, MTF1, AGAP2, MYB, DNMT1, DNMT3A

Products for genes affiliated with Lymphosarcoma

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Sources for Lymphosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet