MCID: LYM019
MIFTS: 50

Lymphosarcoma malady

Rare diseases, Immune diseases categories

Aliases & Classifications for Lymphosarcoma

About this section

Lymphosarcoma, Aliases & Descriptions:

Name: Lymphosarcoma 9 41 11 43
Malignant Lymphoma 9
 
Diffuse Lymphoma 9
Lymphoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:8675
ICD9CM27 200.1
NCIt38 C26919
MeSH33 D008228

Summaries for Lymphosarcoma

About this section


Wikipedia:63 Lymphomas are a group of blood cell tumors that develop from lymphatic tissues. The name often refers to... more...

MalaCards based summary: Lymphosarcoma, also known as malignant lymphoma, is related to mantle cell lymphoma and chronic lymphocytic leukemia. An important gene associated with Lymphosarcoma is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are Lymphocyte Signaling and Selected targets of Oct 3 4. The drugs mitoxantrone and mitoxantrone hydrochloride and the compounds phosphorothioate and ecori have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and liver, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Related Diseases for Lymphosarcoma

About this section

Diseases related to Lymphosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 271)
idRelated DiseaseScoreTop Affiliating Genes
1mantle cell lymphoma30.6BCL2, BMI1
2chronic lymphocytic leukemia30.2BCL2, MYB
3b-cell lymphomas30.2BMI1, BCL2, CD22
4leukemia30.2MYB, BMI1, DNMT1, BCL2, CD22
5lung cancer30.0DNMT1, BCL2
6fibrosarcoma30.0DNMT1, MYB
7hodgkin lymphoma30.0BCL2, BMI1
8hepatitis b30.0DNMT1, MYB
9follicular lymphoma29.8MYB, BMI1, BCL2
10burkitt lymphoma29.8BCL2, BMI1, MYB
11t-cell leukemia29.8BCL2, MYB
12breast cancer29.7BMI1, DNMT1, BCL2
13adenocarcinoma29.7MYB, DNMT1, BCL2
14myeloid leukemia29.7MYB, BMI1, DNMT1, BCL2
15leukemia, acute lymphoblastic29.6CD22, BCL2, MYB
16acute leukemia29.5MYB, BMI1, DNMT1, CD22
17retinoblastoma29.5BCL2, DNMT1, BMI1, MYB
18melanoma29.4BCL2, DNMT1, BMI1, MYB
19primary malignant lymphoma11.1
20mediastinal malignant lymphoma10.5
21salivary gland adenoid cystic carcinoma10.4MYB
22reticulosarcoma10.4
23hypercalcemia10.3
24lymphomatoid granulomatosis10.3
25histiocytosis10.3
26hepatitis10.3
27mediastinitis10.3
28multiple myeloma10.2
29diffuse large b-cell lymphoma10.2
30malignant histiocytosis10.2
31breast lymphoma10.2
32myeloma10.2
33lymphoma, small cleaved-cell, diffuse10.2
34testicular cancer10.2DNMT1, MYB
35sinusitis10.2
36hepatitis c10.2
37pure red-cell aplasia10.2
38cryoglobulinemia10.2
39protein-losing enteropathy10.2
40acquired immunodeficiency syndrome10.2
41sick sinus syndrome10.2
42dermatitis10.2
43lymphoblastic leukemia10.2
44polymorphic reticulosis10.2
45hypersplenism10.2
46neuropathy10.2
47ataxia10.2
48inflammatory bowel disease10.2
49hematologic cancer10.1DNMT1, BMI1
50acute erythroid leukemia10.1MYB, DNMT1

Graphical network of the top 20 diseases related to Lymphosarcoma:



Diseases related to lymphosarcoma

Symptoms for Lymphosarcoma

About this section

Drugs & Therapeutics for Lymphosarcoma

About this section

Drug clinical trials:

Search ClinicalTrials for Lymphosarcoma

Search NIH Clinical Center for Lymphosarcoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Lymphosarcoma

About this section

Anatomical Context for Lymphosarcoma

About this section

MalaCards organs/tissues related to Lymphosarcoma:

31
Lymph node, T cells, Liver, Lung, Colon, B cells, Bone marrow, Bone, Spleen, Spinal cord, Brain, Thyroid, Skin, Testes, Myeloid, Thymus, Heart, Breast, Uterus, Prostate, Cervix, Tongue, Trachea, Skeletal muscle

Animal Models for Lymphosarcoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Lymphosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8BCL2, DNMT1, BMI1
2MP:00020068.7BCL2, DNMT1, BMI1
3MP:00053788.1MYB, BMI1, DNMT1, BCL2
4MP:00053977.7CD22, BCL2, DNMT1, BMI1, MYB
5MP:00053877.6MYB, BMI1, DNMT1, BCL2, CD22
6MP:00053847.6CD22, BCL2, DNMT1, BMI1, MYB
7MP:00107687.5MYB, BMI1, DNMT1, BCL2, CD22

Publications for Lymphosarcoma

About this section

Articles related to Lymphosarcoma:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
The effect of novel rhenium compounds on lymphosarcoma, PC-3 prostate and myeloid leukemia cancer cell lines and an investigation on the DNA binding properties of one of these compounds through electronic spectroscopy. (25221731)
2013
2
Feline small cell lymphosarcoma versus inflammatory bowel disease: treatment and prognosis. (23814916)
2013
3
Proline rich polypeptide (PRP-1) increases the superoxide-producing and ferrihemoglobin reducing activities of cytochrome B(558) isoforms from human lymphosarcoma tissue cells. (21213045)
2011
4
What is your diagnosis? A case of intervertebral disc protrusion in a cat: lymphosarcoma. (16438699)
2006
5
Bilateral exophthalmos in a Holstein cow with lymphosarcoma. (13677600)
2003
6
Role of cystatin C and cysteine proteinases in the development of mouse LS-lymphosarcoma. (11687851)
2001
7
Lymphosarcoma of the pharyngeal region in a 7-month-old beef steer. (10857033)
2000
8
Lymphosarcoma with leukemic blood profile in a Savannah monitor lizard (Varanus exanthematicus). (10367659)
1999
9
Cutaneous, multilocular T-cell lymphosarcoma in a horse--clinical, ultrasonographic and pathological findings. (9557123)
1998
10
Large colon resection for treatment of lymphosarcoma in two horses. (8617649)
1996
11
Clinical and immunohistochemical characterization of thymic lymphosarcoma in a heifer. (8819055)
1996
12
Ataxia associated with lymphosarcoma in a dog. (7559025)
1995
13
Identification and localization of steroid-binding and nonsteroid-binding forms of the glucocorticoid receptor in the mouse P1798 lymphosarcoma. (7748809)
1995
14
Food intolerance mimicking alimentary lymphosarcoma. (8581539)
1995
15
Sonographic findings in horses with mediastinal lymphosarcoma: 13 cases (1985-1992). (7698925)
1994
16
Cross-reactivity between a monoclonal antibody that recognizes a tumor-associated antigen on bovine lymphosarcoma cells and blood lymphocytes from various mammalian species. (1466490)
1992
17
Lymphosarcoma in a desert bighorn sheep. (1457563)
1992
18
Thymic and mammary lymphosarcoma in a three-year-old heifer. (1568914)
1992
19
Changes in metabolism, food and water intake of C3H mice following transplantation of Gardner lymphosarcoma (LSG). (2973618)
1988
20
Multiple mucocutaneous lymphosarcoma in a dog. (17423179)
1988
21
Differential growth characteristics of low and high metastatic variant RAW117 murine lymphosarcoma cells. (3601320)
1987
22
Evaluation of some prognostic factors for advanced multicentric lymphosarcoma in the dog: 147 cases (1978-1981). (3558097)
1987
23
Antitumor activity of protein A administered intravenously to pet cats with leukemia or lymphosarcoma. (2983866)
1985
24
"Coexistent chronic myeloid leukemia and lymphosarcoma in the maxilla: report of a case". (6594459)
1984
25
Cryotherapy of cutaneous lymphosarcoma in a German shepherd. (6548290)
1984
26
Effect of vaccine prepared from Corynebacterium parvum on the growth of Gardner lymphosarcoma in C3H strain mice. (6549499)
1984
27
Lymphosarcoma in a raccoon, Procyon lotor (L.). (6547489)
1984
28
Nocardia brasiliensis lymphocutaneous syndrome in a patient with lymphosarcoma. (6548715)
1984
29
Glycosaminoglycans of solid and ascites forms of the P1798 murine lymphosarcoma. (6688525)
1983
30
A new vasopeptide formed by the action of a Murphy-Sturm lymphosarcoma acid protease on rat plasma kininogen. (6342617)
1983
31
Kinetics of adenosine 3':5'-monophosphate-dependent protein kinase activation and inhibition of thymidine incorporation into DNA in P1798 lymphosarcoma cells. (6305487)
1983
32
An intensive care chemo- or chemoimmunotherapy regimen for patients with intermediate and poor-prognosis acute lymphatic leukemia and leukemic lymphoblastic lymphosarcoma: preliminary results with 14-month median follow-up. (6949235)
1982
33
Thymic lymphosarcoma-cell leukaemia in a crossbred bitch. (7080425)
1982
34
Chemotherapeutic responses in dogs with lymphosarcoma and hypercalcemia. (6897239)
1982
35
Subfractionation of malignant variants of metastatic murine lymphosarcoma cells by countercurrent distribution in two-polymer aqueous phases. (6895470)
1981
36
Heterotransplantation of natural bovine lymphosarcoma to nude mice. (6266831)
1981
37
Induction of lymphosarcoma in sheep by bovine leukemia virus. (6170771)
1981
38
Detection of abscesses and lymphosarcoma with 111In-deferoxamine mesylate. (6894640)
1981
39
A bovine thymic lymphosarcoma case showing a negative serological response to bovine leukemia virus antigens, in a herd with high incidence of enzootic bovine leukosis. (6282011)
1981
40
A possibility of predicting metastatic ability of tumours by implantation into chick embryos. Epigenetic grading of metastasizing and non-metastasizing forms of a hamster lymphosarcoma. (6893184)
1980
41
Characterization of X-tropic endogenous retrovirus-specific RNA uninfected tissues and lymphosarcoma of BALB/c mice. (6255075)
1980
42
Serum migration-inhibitory activity in patients with acute leukemia and early leukemic lymphosarcoma. (387315)
1979
43
Case report; primary lymphosarcoma of the breast. (582062)
1979
44
Determination of blood flow in mouse lymphosarcoma by 133Xe following single and fractionated X-irradiation. (583566)
1979
45
Bovine lymphosarcoma in Nigeria: a report of 2 cases. (583562)
1979
46
Hypocomplementemia associated with naturally occurring lymphosarcoma in pet cats. (221581)
1979
47
The genetics of hereditary lymphosarcoma of pigs. (583606)
1979
48
Ultrasonographic appearance of gastric lymphosarcoma. (103928)
1978
49
Chemotherapists' need for uniform and rational nomenclature and classification of common lymphosarcomas and reticulosarcoma (hematosarcomas or non-Hodgkin's lymphomas). (373918)
1978
50
A lymphopenia-causing agent, probably a virus, found in mice after injection with tumor tissue and with the cell-free filtrates of lymphosarcoma T 86157 (MB). (18150968)
1949

Variations for Lymphosarcoma

About this section

Expression for genes affiliated with Lymphosarcoma

About this section
Search GEO for disease gene expression data for Lymphosarcoma.

Pathways for genes affiliated with Lymphosarcoma

About this section

Pathways related to Lymphosarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BMI1, MYB
29.4DNMT1, BMI1
39.4MYB, BCL2
4
Show member pathways
IL2 signaling events mediated by STAT536
9.4BCL2, MYB
59.3BCL2, BMI1
69.0CD22, BCL2
78.8BCL2, DNMT1, BMI1

Compounds for genes affiliated with Lymphosarcoma

About this section

Compounds related to Lymphosarcoma according to GeneCards Suite gene sharing:

(show all 26)
idCompoundScoreTop Affiliating Genes
1phosphorothioate439.8MYB, DNMT1
2ecori439.8DNMT1, MYB
3cytosine43 2410.7DNMT1, MYB
42-chlorodeoxyadenosine439.7BCL2, DNMT1
5depsipeptide439.6DNMT1, BCL2
6suberoylanilide hydroxamic acid439.6BCL2, DNMT1
7fludarabine43 49 1211.6DNMT1, BCL2
8adpribose439.6DNMT1, BCL2
9adenine43 24 1211.6DNMT1, MYB
10adriamycin439.5BCL2, DNMT1
11guanine43 24 1211.5DNMT1, MYB
12egcg439.5DNMT1, BCL2
13imatinib43 49 1211.2BCL2, DNMT1, MYB
14arsenite43 2410.2BCL2, DNMT1
15retinoid439.2BCL2, DNMT1, MYB
16butyrate439.2BCL2, DNMT1, MYB
17doxorubicin43 49 1211.2BCL2, DNMT1, MYB
18zinc43 2410.2DNMT1, BMI1, MYB
19cycloheximide439.2BCL2, DNMT1, MYB
20progesterone43 28 59 24 1213.1BCL2, DNMT1, MYB
21vegf439.1BCL2, DNMT1, MYB
22thapsigargin43 5910.1BCL2, MYB
23oxygen43 2410.0BCL2, DNMT1, MYB
24retinoic acid43 249.9MYB, DNMT1, BCL2
25estrogen438.7MYB, BMI1, DNMT1, BCL2
26oligonucleotide438.4CD22, BCL2, DNMT1, MYB

GO Terms for genes affiliated with Lymphosarcoma

About this section

Biological processes related to Lymphosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone H3-K4 methylationGO:00515719.5DNMT1, MYB
2chromatin modificationGO:00165689.4DNMT1, BMI1
3thymus developmentGO:00485389.3BCL2, MYB
4negative regulation of transcription from RNA polymerase II promoterGO:00001228.7DNMT1, BMI1, MYB

Molecular functions related to Lymphosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055157.5CD22, BCL2, DNMT1, BMI1, MYB

Products for genes affiliated with Lymphosarcoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Lymphosarcoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet