MCID: LYM019
MIFTS: 53

Lymphosarcoma malady

Immune category

Summaries for Lymphosarcoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 Lymphoma is a type of blood cancer that occurs when B or T lymphocytes, the white blood cells that form... more...

MalaCards: Lymphosarcoma, also known as malignant lymphoma, is related to central nervous system lymphoma and t-cell leukemia. An important gene associated with Lymphosarcoma is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are Selected targets of Oct-3/4 and Validated targets of C-MYC transcriptional repression. The compounds butyrate and zebularine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and spleen, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Classifications for Lymphosarcoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

lymphosarcoma 8 43 10 45
malignant lymphoma 8
lymphoma, diffuse 61
diffuse lymphoma 8


External Ids:

Disease Ontology8 DOID:8675
NCIt40 C26919
MeSH35 D008228
ICD9CM27 200.1

Related Diseases for Lymphosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Lymphosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 300)
idRelated DiseaseScoreTop Affiliating Genes
1central nervous system lymphoma30.7BCL6
2t-cell leukemia30.6TNFRSF8, IGH, MYB, ERVW-1, LGALS1, BCL2
3reticulosarcoma30.5BCL6, TNFRSF8
4b-cell lymphomas30.5TNFRSF8, BMI1, IGH, CD22, BCL6, BCL2
5anaplastic large cell lymphoma30.4TNFRSF8, BCL6
6gastric lymphoma30.4IGH, BCL6
7hepatitis c30.4GSR, ERVW-1, MYB
8lymphoma, diffuse large cell30.4BCL2, BCL6, TNFRSF8
9malignant histiocytosis30.4MYB, TNFRSF8
10acute leukemia30.3BMI1, IGH, MYB, DNMT1, CD22, GSR
11mantle cell lymphoma30.3BMI1, BCL6, BCL2
12systemic lupus erythematosus30.1CD22
13follicular lymphoma30.0BMI1, IGH, MYB, BCL6, BCL2
14burkitt's lymphoma30.0TNFRSF8, BMI1, IGH, MYB, LGALS1, BCL6
15b-cell chronic lymphocytic leukemia29.8BCL2, IGH
16thyroiditis29.8MBL2
17stomach cancer29.8BCL2, DNMT1, MBL2
18chronic myeloid leukemia29.8BCL2, DNMT1, MYB, BMI1
19acute lymphocytic leukemia29.8IGH, MYB, CD22, BCL6, BCL2
20adenocarcinoma29.8MYB, DNMT1, ERVW-1, LGALS1, BCL2, SMARCA4
21adenoma29.8TNFRSF8, DNMT1, LGALS1, BCL2, SMARCA4, GSR
22primary malignant lymphoma11.1
23bone lymphoma10.6
24bladder lymphoma10.5
25thyroid lymphoma10.5
26breast lymphoma10.5
27central nervous system lymphoma, primary10.4
28heart lymphoma10.4
29peripheral t-cell lymphoma10.3
30hypercalcemia10.3
31lung lymphoma10.3
32small intestine lymphoma10.3
33appendix lymphoma10.3
34adult lymphoma10.3
35lymphomatoid granulomatosis10.3
36primary bone lymphoma10.3
37glucocorticoid resistance10.2
38rectum lymphoma10.2
39gastrointestinal lymphoma10.2
40acquired immunodeficiency syndrome10.2
41cryoglobulinemia10.1
42paranasal sinus lymphoma10.1
43testicular lymphoma10.1
44protein-losing enteropathy10.1
45infectious mononucleosis10.1
46sick sinus syndrome10.1
47primary effusion lymphoma10.1
48polymorphic reticulosis10.1
49hepatitis c virus10.1
50hypersplenism10.1

Graphical network of the top 20 diseases related to Lymphosarcoma:



Diseases related to lymphosarcoma

Clinical Features for Lymphosarcoma

Drugs & Therapeutics for Lymphosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lymphosarcoma

Drug clinical trials:

Search ClinicalTrials for Lymphosarcoma

Search NIH Clinical Center for Lymphosarcoma

Search CenterWatch for Lymphosarcoma

Genetic Tests for Lymphosarcoma

Anatomical Context for Lymphosarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Lymphosarcoma:

33
Bone marrow, Lymph node, Spleen, Thymus, Brain, Spinal cord, Heart, Skeletal muscle, Small intestine, Colon, Liver, Lung, Thyroid, Breast, Skin, Uterus, Cervix, Myeloid, T cells, B lymphoblasts, B cells, Tongue, Trachea

Animal Models for Lymphosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Lymphosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.8MTF1, MYB, DNMT1, DNMT3A, CD22, BCL6
2MP:00053978.2MTF1, BMI1, TNFRSF8, MBL2, MYB, DNMT1
3MP:00053878.1SMARCA4, MBL2, TNFRSF8, BMI1, MTF1, MYB

Publications for Lymphosarcoma

Sources:
51PubMed
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Articles related to Lymphosarcoma:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Activation of Cathepsins B and L in Mouse Lymphosarcoma Tissue under the Effect of Cyclophosphamide Is Associated with Apoptosis Induction and Infiltration by Mononuclear Phagocytes. (24319737)
2013
2
The siRNA targeted to mdr1b and mdr1a mRNAs in vivo sensitizes murine lymphosarcoma to chemotherapy. (20470373)
2010
3
Managing the canine lymphosarcoma patient in general practice. (17966344)
2007
4
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. (16322236)
2005
5
Bilateral exophthalmos in a Holstein cow with lymphosarcoma. (13677600)
2003
6
Role of cystatin C and cysteine proteinases in the development of mouse LS-lymphosarcoma. (11687851)
2001
7
Penile prolapse and urethral obstruction secondary to lymphosarcoma of the penis in a dog. (11563447)
2001
8
Differential diagnostic and prognostic value of serum cytokines (soluble CD30, soluble interleukin-2 receptor, interleukin-10 and interleukin-6) in Hodgkin's disease and lymphosarcomas]. (11494447)
2001
9
A novel truncated env gene isolated from a feline leukemia virus-induced thymic lymphosarcoma. (10627556)
2000
10
Central nervous system metastasis of a cutaneous epitheliotropic lymphosarcoma in a dog. (10906257)
2000
11
Microvascular endothelium dysfunction during growth of transplanted lymphosarcoma and glioma in rats. (10746981)
1999
12
Ocular lesions in horses with lymphosarcoma: 21 cases (1977-1997). (9530426)
1998
13
Mandibular lymphosarcoma in a goat. (9699255)
1998
14
Lymphosarcoma in a brook trout. (9249722)
1997
15
Thymic lymphosarcoma of T cell lineage in a koala (Phascolarctos cinereus). (8894024)
1996
16
Metacarpal fracture associated with lymphosarcoma-induced osteolysis in a horse. (7601717)
1995
17
Sonographic findings in horses with mediastinal lymphosarcoma: 13 cases (1985-1992). (7698925)
1994
18
Cross-reactivity between a monoclonal antibody that recognizes a tumor-associated antigen on bovine lymphosarcoma cells and blood lymphocytes from various mammalian species. (1466490)
1992
19
Efficacy and toxicity of doxorubicin/cyclophosphamide maintenance therapy in dogs with multicentric lymphosarcoma. (1748977)
1991
20
Lymphosarcoma with urinary bladder infiltration in a horse. (1752770)
1991
21
C cell hyperplasia and carcinoma developing in sheep with experimentally-induced lymphosarcoma. (1662237)
1991
22
Lymphocyte subpopulations in sheep with lymphosarcoma resulting from experimental infection with bovine leukaemia virus. (2156776)
1990
23
Regression of bovine lymphosarcoma by treatment with cell-wall skeleton of Nocardia rubra. (2750269)
1989
24
Use of viable-cell ELISA for detection of monoclonal antibodies recognizing tumor-associated antigens on bovine lymphosarcoma cells. (2821851)
1987
25
A lymphosarcoma in an Atlantic salmon (Salmo salar). (3682101)
1987
26
Characterisation of a cell line from a human lung lymphosarcoma. Abundance of vimentin-type intermediate filaments. (3888047)
1985
27
Lymphosarcoma involving the mandible in two goats. (3840618)
1985
28
Nocardia brasiliensis lymphocutaneous syndrome in a patient with lymphosarcoma. (6548715)
1984
29
Anti-tumor effects of allogeneic bone marrow transplantation in (NZB X NZW)F1 hybrids with spontaneous lymphosarcoma. (6361137)
1984
30
Landmark article Sept. 21, 1946: Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. By Louis S. Goodman, Maxwell M. Wintrobe, William Dameshek, Morton J. Goodman, Alfred Gilman and Margaret T. McLennan. (6368885)
1984
31
Lymphosarcoma as the cause of ataxia in a horse. (6547423)
1984
32
Clinical aspects of lymphosarcoma in the horse: a clinical report of 16 cases. (6687455)
1983
33
Antigen-activated T lymphocytes infiltrate hepatocyte cultures in a manner comparable to liver-colonizing lymphosarcoma cells. (6336271)
1983
34
Rodent kinin-forming enzyme systems--II. Purification and characterization of an acid protease from Murphy-Sturm lymphosarcoma. (6409112)
1983
35
Salmonellosis in dogs with lymphosarcoma. (6895747)
1982
36
The ability of rat transplantable lymphosarcoma cells to synthesize immunoglobulins. (6897104)
1982
37
Continuous irradiation of a murine lymphosarcoma in vivo. (6897389)
1982
38
Thymic lymphosarcoma cell leukemia. (7101703)
1982
39
Detection of abscesses and lymphosarcoma with 111In-deferoxamine mesylate. (6894640)
1981
40
Bovine lymphosarcoma. (6253780)
1980
41
Malignant tumours of the spermatic cord with contribution of a rare case of lymphosarcoma. (6894587)
1980
42
Lymphosarcoma associated with virus-like intranuclear inclusions in a California king snake (Colubridae: Lampropeltis). (6931937)
1980
43
Properties of a cell-culture line derived from lymphosarcoma P1798. (6892700)
1980
44
Determination of blood flow in mouse lymphosarcoma by 133Xe following single and fractionated X-irradiation. (583566)
1979
45
Clinical and radiological features of anterior mediastinal lymphosarcoma in the cat: a reveiw of 30 cases. (583589)
1979
46
Lymphosarcoma in tarsi of a cat. (583148)
1979
47
Lymphosarcoma of the duodenum associated with carcinoma of the lung. Five-year survival. (220869)
1979
48
Cavitary pulmonary lymphosarcoma masquerading as rheumatoid lung disease. (1083917)
1976
49
Opportunistic cutaneous Mycobacterium marinum infection mimicking Mycobacterium ulcerans in lymphosarcoma. (4800424)
1973
50
Malignant tumours of the stomach arising from the lympho-reticular system. A report of 10 cases of lymphosarcoma and reticulosarcoma of the stomach. (14492653)
1961

Genetic Variations for Lymphosarcoma

Expression for genes affiliated with Lymphosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Lymphosarcoma

Search GEO for disease gene expression data for Lymphosarcoma.

Pathways for genes affiliated with Lymphosarcoma

Sources:
12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology
See all sources

Pathways related to Lymphosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DNMT3A, DNMT1, BMI1
29.8DNMT3A, LGALS1, BCL2
39.8BCL2, DNMT3A, DNMT1, BMI1
49.7SMARCA4, DNMT3A, DNMT1, BMI1
59.6BCL6, LGALS1, MYB, BMI1

Compounds for genes affiliated with Lymphosarcoma

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Lymphosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1butyrate4510.5MYB
2zebularine4510.5DNMT1, DCTD
3cycloheximide4510.5MTF1
4o-ethylhydroxylamine4510.5GSR, H6PD
5estrogen4510.5BCL6, MBL2
6no-dimethylhydroxylamine4510.5GSR, H6PD
73-deazaneplanocin a hydrochloride6010.4DNMT1, DNMT3A
8unc 06466010.4DNMT1, DNMT3A
9unc 06386010.4DNMT1, DNMT3A
10bix 012946010.4DNMT1, DNMT3A
11sgc 09466010.4DNMT1, DNMT3A
122-chlorodeoxyadenosine4510.4DCTD, DNMT1, BCL2
13serine4510.3MTF1, ERVW-1
14dihydrofolate4510.3H6PD, DNMT1, SMARCA4
15cytidine45 11 2412.2BCL6, DNMT1, DCTD
16imatinib45 50 1112.1MYB, DNMT1, BCL6, BCL2
17cadmium45 2411.1MTF1, DNMT1, SMARCA4
18folate4510.1H6PD, DNMT1, DNMT3A, GSR
19cyclophosphamide45 50 1112.0MBL2, BCL6, BCL2, GSR
20retinoid4510.0MYB, DNMT1, LGALS1, BCL2
21cytosine45 2411.0DNMT3A, DNMT1, MYB
22monosaccharide4510.0LGALS1, MBL2
23doxorubicin45 50 1111.9GSR, BCL2, BCL6, DNMT1, MYB
24tuberculin459.9MBL2, TNFRSF8
25galactose459.8H6PD, MBL2, LGALS1
26agarose459.8MBL2, IGH, LGALS1, BCL2
27fructose-1,6-bisphosphate459.8GSR, H6PD
28glyceraldehyde 3-phosphate459.8H6PD, ERVW-1, LGALS1, GSR
29agar459.8DNMT1, ERVW-1, LGALS1, SMARCA4
30progesterone45 60 29 11 2413.7MBL2, MYB, DNMT1, BCL2, SMARCA4
31adenylate459.7H6PD, MYB, DNMT1, ASRGL1, GSR
32methionine459.7LGALS1, ERVW-1, DNMT1, MYB
33superoxide45 2410.7H6PD, MBL2, MTF1, LGALS1, GSR
34paraffin459.7MBL2, TNFRSF8, LGALS1, BCL6, BCL2
35polysaccharide459.7H6PD, MBL2, CD22, ERVW-1, LGALS1
36h2o2459.7GSR, BCL2, MYB, MTF1, H6PD
37steroid459.6H6PD, MBL2, MYB, DNMT1, ERVW-1, SMARCA4
38polyacrylamide459.6H6PD, IGH, ERVW-1, LGALS1
39oxygen45 2410.5MBL2, MTF1, MYB, DNMT1, ERVW-1, LGALS1
40oligonucleotide459.1IGH, MYB, DNMT1, DNMT3A, CD22, ERVW-1
41lipid459.0H6PD, MBL2, TNFRSF8, MYB, ERVW-1, LGALS1
42cysteine458.9H6PD, MBL2, MTF1, MYB, DNMT1, ERVW-1
43tyrosine458.6MBL2, TNFRSF8, MTF1, MYB, DNMT1, CD22
44zinc45 249.6SMARCA4, H6PD, MBL2, TNFRSF8, BMI1, MTF1

GO Terms for genes affiliated with Lymphosarcoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.1BCL6, DNMT1

Biological processes related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA methylationGO:00630610.1DNMT3A, DNMT1
2DNA methylation on cytosine within a CG sequenceGO:01042410.1SMARCA4, DNMT3A
3positive regulation of histone H3-K4 methylationGO:05157110.1DNMT1, MYB
4methylation-dependent chromatin silencingGO:00634610.1DNMT3A, SMARCA4
5negative regulation of cell growthGO:0303089.5SMARCA4, BCL2, BCL6
6negative regulation of transcription from RNA polymerase II promoterGO:0001229.4SMARCA4, BCL6, DNMT3A, DNMT1, MYB, BMI1

Molecular functions related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA (cytosine-5-)-methyltransferase activityGO:00388610.0DNMT3A, DNMT1
2chromatin bindingGO:0036829.3MYB, DNMT3A, BCL6, SMARCA4
3protein bindingGO:0055158.0BMI1, MTF1, AGAP2, MYB, DNMT1, DNMT3A

Products for genes affiliated with Lymphosarcoma

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Sources for Lymphosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet