MCID: LYM019
MIFTS: 54

Lymphosarcoma malady

Rare diseases, Cancer diseases, Immune diseases categories

Summaries for Lymphosarcoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 Lymphoma is a group of blood cell tumors that develop from lymphocytes. It is sometimes used to refer to... more...

MalaCards: Lymphosarcoma, also known as malignant lymphoma, is related to leukemia and b-cell lymphomas. An important gene associated with Lymphosarcoma is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are Lymphocyte Signaling and Selected targets of Oct 3 4. The compounds phosphorothioate and ecori have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and liver, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Lymphosarcoma

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

lymphosarcoma 9 44 11 46
malignant lymphoma 9
lymphoma, diffuse 63
diffuse lymphoma 9


External Ids:

Disease Ontology9 DOID:8675
ICD9CM28 200.1
MeSH36 D008228
NCIt41 C26919

Related Diseases for Lymphosarcoma

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18GeneCards, 19GeneDecks
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Diseases related to Lymphosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 286)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia30.9BCL2, MYB, DNMT1, CD22, BMI1
2b-cell lymphomas30.4CD22, BMI1, BCL2
3mantle cell lymphoma30.4BCL2, BMI1
4hodgkin's lymphoma30.2BMI1, BCL2
5chronic lymphocytic leukemia30.1BCL2, MYB
6acute leukemia29.9MYB, BMI1, DNMT1, CD22
7hepatitis b29.9MYB, DNMT1
8fibrosarcoma29.9DNMT1, MYB
9follicular lymphoma29.9BMI1, BCL2, MYB
10burkitt's lymphoma29.9BMI1, MYB, BCL2
11lung cancer29.8MYB, DNMT1, BCL2
12breast cancer29.8BMI1, DNMT1, BCL2
13t-cell leukemia29.8MYB, BCL2
14acute lymphocytic leukemia29.8MYB, BCL2, CD22
15adenocarcinoma29.8BCL2, DNMT1, MYB
16retinoblastoma29.8DNMT1, MYB, BMI1, BCL2
17chronic myeloid leukemia29.7BCL2, MYB, BMI1, DNMT1
18myeloid leukemia29.7MYB, DNMT1, BCL2, BMI1
19melanoma29.7BCL2, MYB, BMI1, DNMT1
20primary malignant lymphoma11.1
21mediastinal malignant lymphoma10.4
22reticulosarcoma10.3
23hypercalcemia10.3
24histiocytosis10.3
25lymphomatoid granulomatosis10.3
26hepatitis10.2
27mediastinitis10.2
28malignant histiocytosis10.2
29diffuse large b-cell lymphoma10.2
30lymphoblastic leukemia10.2
31multiple myeloma10.2
32myeloma10.2
33lymphoma, small cleaved-cell, diffuse10.2
34hepatitis c10.2
35pure red-cell aplasia10.2
36cryoglobulinemia10.2
37protein-losing enteropathy10.2
38acquired immunodeficiency syndrome10.2
39infectious mononucleosis10.2
40breast lymphoma10.2
41sick sinus syndrome10.2
42dermatitis10.2
43polymorphic reticulosis10.2
44sinusitis10.2
45hypersplenism10.1
46inflammatory bowel disease10.1
47neuropathy10.1
48ataxia10.1
49adenoid cystic carcinoma10.1MYB
50klinefelter's syndrome10.1

Graphical network of the top 20 diseases related to Lymphosarcoma:



Diseases related to lymphosarcoma

Symptoms for Lymphosarcoma

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Drugs & Therapeutics for Lymphosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Lymphosarcoma

Drug clinical trials:

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Search NIH Clinical Center for Lymphosarcoma

Search CenterWatch for Lymphosarcoma

Genetic Tests for Lymphosarcoma

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Anatomical Context for Lymphosarcoma

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34MalaCards
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MalaCards organs/tissues related to Lymphosarcoma:

34
Lymph node, T cells, Liver, Lung, Colon, Bone marrow, Spleen, Bone, B cells, Thyroid, Skin, Testes, Brain, Spinal cord, Trachea, Myeloid, Breast, Tongue, Uterus, Heart, Thymus, Cervix, Skeletal muscle

Animal Models for Lymphosarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Lymphosarcoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8BCL2, DNMT1, BMI1
2MP:00020068.7BCL2, DNMT1, BMI1
3MP:00053788.1MYB, BMI1, DNMT1, BCL2
4MP:00053977.7CD22, BCL2, DNMT1, BMI1, MYB
5MP:00053877.6MYB, BMI1, DNMT1, BCL2, CD22
6MP:00053847.6CD22, BCL2, DNMT1, BMI1, MYB
7MP:00107687.5MYB, BMI1, DNMT1, BCL2, CD22

Publications for Lymphosarcoma

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53PubMed
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Articles related to Lymphosarcoma:

(show top 50)    (show all 521)
idTitleAuthorsYear
1
Feline small cell lymphosarcoma versus inflammatory bowel disease: treatment and prognosis. (23814916)
2013
2
Idiopathic hemorrhagic pericardial effusion as a precursor to epicardial lymphosarcoma in three cows. (22676351)
2012
3
Proline rich polypeptide (PRP-1) increases the superoxide-producing and ferrihemoglobin reducing activities of cytochrome B(558) isoforms from human lymphosarcoma tissue cells. (21213045)
2011
4
What is your diagnosis? A case of intervertebral disc protrusion in a cat: lymphosarcoma. (16438699)
2006
5
Bilateral exophthalmos in a Holstein cow with lymphosarcoma. (13677600)
2003
6
Role of cystatin C and cysteine proteinases in the development of mouse LS-lymphosarcoma. (11687851)
2001
7
Lymphosarcoma of the pharyngeal region in a 7-month-old beef steer. (10857033)
2000
8
Lymphosarcoma with leukemic blood profile in a Savannah monitor lizard (Varanus exanthematicus). (10367659)
1999
9
Cutaneous, multilocular T-cell lymphosarcoma in a horse--clinical, ultrasonographic and pathological findings. (9557123)
1998
10
Large colon resection for treatment of lymphosarcoma in two horses. (8617649)
1996
11
Clinical and immunohistochemical characterization of thymic lymphosarcoma in a heifer. (8819055)
1996
12
Ataxia associated with lymphosarcoma in a dog. (7559025)
1995
13
Identification and localization of steroid-binding and nonsteroid-binding forms of the glucocorticoid receptor in the mouse P1798 lymphosarcoma. (7748809)
1995
14
Food intolerance mimicking alimentary lymphosarcoma. (8581539)
1995
15
Sonographic findings in horses with mediastinal lymphosarcoma: 13 cases (1985-1992). (7698925)
1994
16
Cross-reactivity between a monoclonal antibody that recognizes a tumor-associated antigen on bovine lymphosarcoma cells and blood lymphocytes from various mammalian species. (1466490)
1992
17
Lymphosarcoma in a desert bighorn sheep. (1457563)
1992
18
Thymic and mammary lymphosarcoma in a three-year-old heifer. (1568914)
1992
19
Glucocorticoids repress ribosome biosynthesis in lymphosarcoma cells by affecting gene expression at the level of transcription, posttranscription and translation. (2357465)
1990
20
Changes in metabolism, food and water intake of C3H mice following transplantation of Gardner lymphosarcoma (LSG). (2973618)
1988
21
Multiple mucocutaneous lymphosarcoma in a dog. (17423179)
1988
22
Differential growth characteristics of low and high metastatic variant RAW117 murine lymphosarcoma cells. (3601320)
1987
23
Evaluation of some prognostic factors for advanced multicentric lymphosarcoma in the dog: 147 cases (1978-1981). (3558097)
1987
24
Antitumor activity of protein A administered intravenously to pet cats with leukemia or lymphosarcoma. (2983866)
1985
25
"Coexistent chronic myeloid leukemia and lymphosarcoma in the maxilla: report of a case". (6594459)
1984
26
Cryotherapy of cutaneous lymphosarcoma in a German shepherd. (6548290)
1984
27
Effect of vaccine prepared from Corynebacterium parvum on the growth of Gardner lymphosarcoma in C3H strain mice. (6549499)
1984
28
Lymphosarcoma in a raccoon, Procyon lotor (L.). (6547489)
1984
29
Glycosaminoglycans of solid and ascites forms of the P1798 murine lymphosarcoma. (6688525)
1983
30
A new vasopeptide formed by the action of a Murphy-Sturm lymphosarcoma acid protease on rat plasma kininogen. (6342617)
1983
31
Kinetics of adenosine 3':5'-monophosphate-dependent protein kinase activation and inhibition of thymidine incorporation into DNA in P1798 lymphosarcoma cells. (6305487)
1983
32
An intensive care chemo- or chemoimmunotherapy regimen for patients with intermediate and poor-prognosis acute lymphatic leukemia and leukemic lymphoblastic lymphosarcoma: preliminary results with 14-month median follow-up. (6949235)
1982
33
Thymic lymphosarcoma-cell leukaemia in a crossbred bitch. (7080425)
1982
34
Chemotherapeutic responses in dogs with lymphosarcoma and hypercalcemia. (6897239)
1982
35
Subfractionation of malignant variants of metastatic murine lymphosarcoma cells by countercurrent distribution in two-polymer aqueous phases. (6895470)
1981
36
Heterotransplantation of natural bovine lymphosarcoma to nude mice. (6266831)
1981
37
Induction of lymphosarcoma in sheep by bovine leukemia virus. (6170771)
1981
38
Detection of abscesses and lymphosarcoma with 111In-deferoxamine mesylate. (6894640)
1981
39
A bovine thymic lymphosarcoma case showing a negative serological response to bovine leukemia virus antigens, in a herd with high incidence of enzootic bovine leukosis. (6282011)
1981
40
A possibility of predicting metastatic ability of tumours by implantation into chick embryos. Epigenetic grading of metastasizing and non-metastasizing forms of a hamster lymphosarcoma. (6893184)
1980
41
Characterization of X-tropic endogenous retrovirus-specific RNA uninfected tissues and lymphosarcoma of BALB/c mice. (6255075)
1980
42
Serum migration-inhibitory activity in patients with acute leukemia and early leukemic lymphosarcoma. (387315)
1979
43
Case report; primary lymphosarcoma of the breast. (582062)
1979
44
Determination of blood flow in mouse lymphosarcoma by 133Xe following single and fractionated X-irradiation. (583566)
1979
45
Bovine lymphosarcoma in Nigeria: a report of 2 cases. (583562)
1979
46
Hypocomplementemia associated with naturally occurring lymphosarcoma in pet cats. (221581)
1979
47
The genetics of hereditary lymphosarcoma of pigs. (583606)
1979
48
Ultrasonographic appearance of gastric lymphosarcoma. (103928)
1978
49
Chemotherapists' need for uniform and rational nomenclature and classification of common lymphosarcomas and reticulosarcoma (hematosarcomas or non-Hodgkin's lymphomas). (373918)
1978
50
A lymphopenia-causing agent, probably a virus, found in mice after injection with tumor tissue and with the cell-free filtrates of lymphosarcoma T 86157 (MB). (18150968)
1949

Variations for Lymphosarcoma

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Expression for genes affiliated with Lymphosarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphosarcoma

Search GEO for disease gene expression data for Lymphosarcoma.

Pathways for genes affiliated with Lymphosarcoma

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Sources:
51PathCards, 5Cell Signaling Technology, 13EMD Millipore, 39NCBI BioSystems Database, 31KEGG
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Pathways related to Lymphosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BMI1, MYB
29.4DNMT1, BMI1
39.4DNMT1, BMI1
49.4MYB, BCL2
5
Show member pathways
IL2 signaling events mediated by STAT539
9.4BCL2, MYB
69.3BCL2, BMI1
79.0CD22, BCL2
88.8BCL2, DNMT1, BMI1

Compounds for genes affiliated with Lymphosarcoma

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46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Lymphosarcoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1phosphorothioate469.8MYB, DNMT1
2ecori469.8DNMT1, MYB
3cytosine46 2510.7DNMT1, MYB
42-chlorodeoxyadenosine469.7BCL2, DNMT1
5depsipeptide469.6DNMT1, BCL2
6suberoylanilide hydroxamic acid469.6BCL2, DNMT1
7fludarabine46 52 1211.6DNMT1, BCL2
8adpribose469.6DNMT1, BCL2
9adenine46 25 1211.6DNMT1, MYB
10adriamycin469.5BCL2, DNMT1
11guanine46 25 1211.5DNMT1, MYB
12egcg469.5DNMT1, BCL2
13imatinib46 52 1211.2BCL2, DNMT1, MYB
14arsenite46 2510.2BCL2, DNMT1
15retinoid469.2BCL2, DNMT1, MYB
16butyrate469.2BCL2, DNMT1, MYB
17doxorubicin46 52 1211.2BCL2, DNMT1, MYB
18zinc46 2510.2DNMT1, BMI1, MYB
19cycloheximide469.2BCL2, DNMT1, MYB
20progesterone46 30 62 25 1213.1BCL2, DNMT1, MYB
21vegf469.1BCL2, DNMT1, MYB
22thapsigargin46 6210.1BCL2, MYB
23oxygen46 2510.0BCL2, DNMT1, MYB
24retinoic acid46 259.9MYB, DNMT1, BCL2
25estrogen468.7MYB, BMI1, DNMT1, BCL2
26oligonucleotide468.4CD22, BCL2, DNMT1, MYB

GO Terms for genes affiliated with Lymphosarcoma

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17Gene Ontology
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Biological processes related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone H3-K4 methylationGO:0515719.5DNMT1, MYB
2chromatin modificationGO:0165689.4DNMT1, BMI1
3thymus developmentGO:0485389.3BCL2, MYB
4negative regulation of transcription from RNA polymerase II promoterGO:0001228.7DNMT1, BMI1, MYB

Molecular functions related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.5CD22, BCL2, DNMT1, BMI1, MYB

Products for genes affiliated with Lymphosarcoma

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Sources for Lymphosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet