MCID: LYM019
MIFTS: 59

Lymphosarcoma malady

Rare diseases, Cancer diseases, Immune diseases categories
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Summaries for Lymphosarcoma

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Wikipedia:65 Lymphoma is a group of blood cell tumors that develop from lymphocytes. It is sometimes used to refer to... more...

MalaCards based summary: Lymphosarcoma, also known as lymphoma, malignant, is related to mantle cell lymphoma and hodgkin's lymphoma. An important gene associated with Lymphosarcoma is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are Lymphocyte Signaling and Selected targets of Oct 3 4. The drugs thiotepa and irinotecan and the compounds phosphorothioate and ecori have been mentioned in the context of this disorder. Affiliated tissues include lymph node, t cells and liver, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Lymphosarcoma

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Lymphosarcoma, Aliases & Descriptions:

Name: Lymphosarcoma 8 42 10 44
Lymphoma, Malignant 62
Malignant Lymphoma 8
 
Lymphoma, Diffuse 62
Diffuse Lymphoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:8675
NCIt39 C26919
ICD9CM27 200.1
MeSH34 D008228

Related Diseases for Lymphosarcoma

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Diseases related to Lymphosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 292)
idRelated DiseaseScoreTop Affiliating Genes
1mantle cell lymphoma30.6BCL2, BMI1
2hodgkin's lymphoma30.3BMI1, BCL2
3chronic lymphocytic leukemia30.2BCL2, MYB
4b-cell lymphomas30.2CD22, BMI1, BCL2
5leukemia30.2BCL2, MYB, DNMT1, CD22, BMI1
6acute lymphoblastic leukemia30.1MYB, BCL2, CD22
7fibrosarcoma30.0DNMT1, MYB
8hepatitis b30.0MYB, DNMT1
9follicular lymphoma29.8BMI1, BCL2, MYB
10burkitt's lymphoma29.8BMI1, MYB, BCL2
11t-cell leukemia29.8MYB, BCL2
12lung cancer29.8MYB, DNMT1, BCL2
13breast cancer29.7BMI1, DNMT1, BCL2
14adenocarcinoma29.7BCL2, DNMT1, MYB
15myeloid leukemia29.7MYB, DNMT1, BCL2, BMI1
16retinoblastoma29.5DNMT1, MYB, BMI1, BCL2
17chronic myeloid leukemia29.5BCL2, MYB, BMI1, DNMT1
18melanoma29.4BCL2, MYB, BMI1, DNMT1
19acute leukemia29.3MYB, BMI1, DNMT1, CD22
20primary malignant lymphoma11.1
21mediastinal malignant lymphoma10.5
22salivary gland adenoid cystic carcinoma10.4MYB
23reticulosarcoma10.4
24hypercalcemia10.3
25lymphomatoid granulomatosis10.3
26histiocytosis10.3
27hepatitis10.3
28mediastinitis10.3
29diffuse large b-cell lymphoma10.2
30multiple myeloma10.2
31breast lymphoma10.2
32malignant histiocytosis10.2
33lymphoblastic leukemia10.2
34myeloma10.2
35lymphoma, small cleaved-cell, diffuse10.2
36testicular cancer10.2DNMT1, MYB
37sinusitis10.2
38cryoglobulinemia10.2
39hepatitis c10.2
40pure red-cell aplasia10.2
41acquired immunodeficiency syndrome10.2
42sick sinus syndrome10.2
43protein-losing enteropathy10.2
44infectious mononucleosis10.2
45polymorphic reticulosis10.2
46hypersplenism10.1
47neuropathy10.1
48ataxia10.1
49inflammatory bowel disease10.1
50hematologic cancer10.1DNMT1, BMI1

Graphical network of the top 20 diseases related to Lymphosarcoma:



Diseases related to lymphosarcoma

Symptoms for Lymphosarcoma

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Drugs & Therapeutics for Lymphosarcoma

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Drug clinical trials:

Search ClinicalTrials for Lymphosarcoma

Search NIH Clinical Center for Lymphosarcoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Lymphosarcoma

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Anatomical Context for Lymphosarcoma

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MalaCards organs/tissues related to Lymphosarcoma:

32
Lymph node, T cells, Liver, Lung, Colon, B cells, Bone marrow, Bone, Spleen, Spinal cord, Brain, Thyroid, Skin, Testes, Myeloid, Thymus, Heart, Breast, Uterus, Prostate, Cervix, Tongue, Trachea, Skeletal muscle

Animal Models for Lymphosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Lymphosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.8BCL2, DNMT1, BMI1
2MP:00020068.7BCL2, DNMT1, BMI1
3MP:00053788.1MYB, BMI1, DNMT1, BCL2
4MP:00053977.7CD22, BCL2, DNMT1, BMI1, MYB
5MP:00053877.6MYB, BMI1, DNMT1, BCL2, CD22
6MP:00053847.6CD22, BCL2, DNMT1, BMI1, MYB
7MP:00107687.5MYB, BMI1, DNMT1, BCL2, CD22

Publications for Lymphosarcoma

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Articles related to Lymphosarcoma:

(show top 50)    (show all 524)
idTitleAuthorsYear
1
The effect of novel rhenium compounds on lymphosarcoma, PC-3 prostate and myeloid leukemia cancer cell lines and an investigation on the DNA binding properties of one of these compounds through electronic spectroscopy. (25221731)
2013
2
Feline small cell lymphosarcoma versus inflammatory bowel disease: treatment and prognosis. (23814916)
2013
3
Idiopathic hemorrhagic pericardial effusion as a precursor to epicardial lymphosarcoma in three cows. (22676351)
2012
4
Proline rich polypeptide (PRP-1) increases the superoxide-producing and ferrihemoglobin reducing activities of cytochrome B(558) isoforms from human lymphosarcoma tissue cells. (21213045)
2011
5
What is your diagnosis? A case of intervertebral disc protrusion in a cat: lymphosarcoma. (16438699)
2006
6
Bilateral exophthalmos in a Holstein cow with lymphosarcoma. (13677600)
2003
7
Role of cystatin C and cysteine proteinases in the development of mouse LS-lymphosarcoma. (11687851)
2001
8
Lymphosarcoma of the pharyngeal region in a 7-month-old beef steer. (10857033)
2000
9
Lymphosarcoma with leukemic blood profile in a Savannah monitor lizard (Varanus exanthematicus). (10367659)
1999
10
Cutaneous, multilocular T-cell lymphosarcoma in a horse--clinical, ultrasonographic and pathological findings. (9557123)
1998
11
Large colon resection for treatment of lymphosarcoma in two horses. (8617649)
1996
12
Clinical and immunohistochemical characterization of thymic lymphosarcoma in a heifer. (8819055)
1996
13
Ataxia associated with lymphosarcoma in a dog. (7559025)
1995
14
Identification and localization of steroid-binding and nonsteroid-binding forms of the glucocorticoid receptor in the mouse P1798 lymphosarcoma. (7748809)
1995
15
Food intolerance mimicking alimentary lymphosarcoma. (8581539)
1995
16
Sonographic findings in horses with mediastinal lymphosarcoma: 13 cases (1985-1992). (7698925)
1994
17
Cross-reactivity between a monoclonal antibody that recognizes a tumor-associated antigen on bovine lymphosarcoma cells and blood lymphocytes from various mammalian species. (1466490)
1992
18
Lymphosarcoma in a desert bighorn sheep. (1457563)
1992
19
Thymic and mammary lymphosarcoma in a three-year-old heifer. (1568914)
1992
20
Glucocorticoids repress ribosome biosynthesis in lymphosarcoma cells by affecting gene expression at the level of transcription, posttranscription and translation. (2357465)
1990
21
Changes in metabolism, food and water intake of C3H mice following transplantation of Gardner lymphosarcoma (LSG). (2973618)
1988
22
Multiple mucocutaneous lymphosarcoma in a dog. (17423179)
1988
23
Differential growth characteristics of low and high metastatic variant RAW117 murine lymphosarcoma cells. (3601320)
1987
24
Evaluation of some prognostic factors for advanced multicentric lymphosarcoma in the dog: 147 cases (1978-1981). (3558097)
1987
25
Antitumor activity of protein A administered intravenously to pet cats with leukemia or lymphosarcoma. (2983866)
1985
26
"Coexistent chronic myeloid leukemia and lymphosarcoma in the maxilla: report of a case". (6594459)
1984
27
Cryotherapy of cutaneous lymphosarcoma in a German shepherd. (6548290)
1984
28
Effect of vaccine prepared from Corynebacterium parvum on the growth of Gardner lymphosarcoma in C3H strain mice. (6549499)
1984
29
Lymphosarcoma in a raccoon, Procyon lotor (L.). (6547489)
1984
30
Glycosaminoglycans of solid and ascites forms of the P1798 murine lymphosarcoma. (6688525)
1983
31
A new vasopeptide formed by the action of a Murphy-Sturm lymphosarcoma acid protease on rat plasma kininogen. (6342617)
1983
32
Kinetics of adenosine 3':5'-monophosphate-dependent protein kinase activation and inhibition of thymidine incorporation into DNA in P1798 lymphosarcoma cells. (6305487)
1983
33
An intensive care chemo- or chemoimmunotherapy regimen for patients with intermediate and poor-prognosis acute lymphatic leukemia and leukemic lymphoblastic lymphosarcoma: preliminary results with 14-month median follow-up. (6949235)
1982
34
Thymic lymphosarcoma-cell leukaemia in a crossbred bitch. (7080425)
1982
35
Chemotherapeutic responses in dogs with lymphosarcoma and hypercalcemia. (6897239)
1982
36
Subfractionation of malignant variants of metastatic murine lymphosarcoma cells by countercurrent distribution in two-polymer aqueous phases. (6895470)
1981
37
Heterotransplantation of natural bovine lymphosarcoma to nude mice. (6266831)
1981
38
Induction of lymphosarcoma in sheep by bovine leukemia virus. (6170771)
1981
39
Detection of abscesses and lymphosarcoma with 111In-deferoxamine mesylate. (6894640)
1981
40
A bovine thymic lymphosarcoma case showing a negative serological response to bovine leukemia virus antigens, in a herd with high incidence of enzootic bovine leukosis. (6282011)
1981
41
A possibility of predicting metastatic ability of tumours by implantation into chick embryos. Epigenetic grading of metastasizing and non-metastasizing forms of a hamster lymphosarcoma. (6893184)
1980
42
Characterization of X-tropic endogenous retrovirus-specific RNA uninfected tissues and lymphosarcoma of BALB/c mice. (6255075)
1980
43
Case report; primary lymphosarcoma of the breast. (582062)
1979
44
Determination of blood flow in mouse lymphosarcoma by 133Xe following single and fractionated X-irradiation. (583566)
1979
45
Bovine lymphosarcoma in Nigeria: a report of 2 cases. (583562)
1979
46
Hypocomplementemia associated with naturally occurring lymphosarcoma in pet cats. (221581)
1979
47
The genetics of hereditary lymphosarcoma of pigs. (583606)
1979
48
Ultrasonographic appearance of gastric lymphosarcoma. (103928)
1978
49
Chemotherapists' need for uniform and rational nomenclature and classification of common lymphosarcomas and reticulosarcoma (hematosarcomas or non-Hodgkin's lymphomas). (373918)
1978
50
A lymphopenia-causing agent, probably a virus, found in mice after injection with tumor tissue and with the cell-free filtrates of lymphosarcoma T 86157 (MB). (18150968)
1949

Variations for Lymphosarcoma

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Expression for genes affiliated with Lymphosarcoma

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Expression patterns in normal tissues for genes affiliated with Lymphosarcoma

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Pathways for genes affiliated with Lymphosarcoma

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Pathways related to Lymphosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MYB, BMI1
29.4DNMT1, BMI1
39.4DNMT1, BMI1
49.4BCL2, MYB
5
Show member pathways
IL2 signaling events mediated by STAT537
9.4MYB, BCL2
69.3BMI1, BCL2
79.0BCL2, CD22
88.8BMI1, DNMT1, BCL2

Compounds for genes affiliated with Lymphosarcoma

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Compounds related to Lymphosarcoma according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1phosphorothioate449.8MYB, DNMT1
2ecori449.8DNMT1, MYB
3cytosine44 2410.7DNMT1, MYB
42-chlorodeoxyadenosine449.7BCL2, DNMT1
5depsipeptide449.6DNMT1, BCL2
6suberoylanilide hydroxamic acid449.6BCL2, DNMT1
7fludarabine44 50 1111.6DNMT1, BCL2
8adpribose449.6DNMT1, BCL2
9adenine44 24 1111.6DNMT1, MYB
10adriamycin449.5BCL2, DNMT1
11guanine44 24 1111.5DNMT1, MYB
12egcg449.5DNMT1, BCL2
13imatinib44 50 1111.2BCL2, DNMT1, MYB
14arsenite44 2410.2BCL2, DNMT1
15retinoid449.2BCL2, DNMT1, MYB
16butyrate449.2BCL2, DNMT1, MYB
17doxorubicin44 50 1111.2BCL2, DNMT1, MYB
18zinc44 2410.2DNMT1, BMI1, MYB
19cycloheximide449.2BCL2, DNMT1, MYB
20progesterone44 28 61 24 1113.1BCL2, DNMT1, MYB
21vegf449.1BCL2, DNMT1, MYB
22thapsigargin44 6110.1BCL2, MYB
23oxygen44 2410.0BCL2, DNMT1, MYB
24retinoic acid44 249.9MYB, DNMT1, BCL2
25estrogen448.7MYB, BMI1, DNMT1, BCL2
26oligonucleotide448.4CD22, BCL2, DNMT1, MYB

GO Terms for genes affiliated with Lymphosarcoma

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Biological processes related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of histone H3-K4 methylationGO:0515719.5DNMT1, MYB
2chromatin modificationGO:0165689.4DNMT1, BMI1
3thymus developmentGO:0485389.3BCL2, MYB
4negative regulation of transcription from RNA polymerase II promoterGO:0001228.7DNMT1, BMI1, MYB

Molecular functions related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055157.5CD22, BCL2, DNMT1, BMI1, MYB

Products for genes affiliated with Lymphosarcoma

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Sources for Lymphosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet