MCID: LYM019
MIFTS: 54

Lymphosarcoma malady

Immune diseases category

Summaries for Lymphosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 Lymphoma is a type of blood cancer that occurs when B or T lymphocytes, the white blood cells that form... more...

MalaCards: Lymphosarcoma, also known as malignant lymphoma, is related to leukemia and central nervous system lymphoma. An important gene associated with Lymphosarcoma is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are Selected targets of Oct-3/4 and Validated targets of C-MYC transcriptional repression. The compounds butyrate and zebularine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and bone, and related mouse phenotypes are cellular and hematopoietic system.

Aliases & Classifications for Lymphosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

lymphosarcoma 8 42 10 44
malignant lymphoma 8
lymphoma, diffuse 60
diffuse lymphoma 8


External Ids:

Disease Ontology8 DOID:8675
NCIt39 C26919
MeSH34 D008228
ICD9CM27 200.1

Related Diseases for Lymphosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Lymphosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 310)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.0DNMT1, MYB, IGH, DCTD, BMI1, MBL2
2central nervous system lymphoma30.7BCL6
3reticulosarcoma30.5BCL6, TNFRSF8
4anaplastic large cell lymphoma30.4TNFRSF8, BCL6
5gastric lymphoma30.4IGH, BCL6
6malignant histiocytosis30.3MYB, TNFRSF8
7hepatitis30.3DNMT1, DNMT3A, GSR
8acute leukemia30.3BMI1, IGH, MYB, DNMT1, CD22, GSR
9mantle cell lymphoma30.2BMI1, BCL6, BCL2
10myeloma30.2TNFRSF8, IGH, LGALS1, BCL6, BCL2
11hepatitis c30.1GSR, ERVW-1, MYB
12hodgkin's lymphoma30.1TNFRSF8, BMI1, IGH, LGALS1, BCL6, BCL2
13lymphoma, diffuse large cell30.1BCL2, BCL6, TNFRSF8
14burkitt's lymphoma30.0TNFRSF8, BCL6, BCL2
15systemic lupus erythematosus30.0CD22
16rheumatoid arthritis30.0MBL2, TNFRSF8, MYB, ERVW-1, LGALS1
17non-hodgkin lymphoma30.0TNFRSF8, BMI1, IGH, MYB, BCL6, BCL2
18pneumonia30.0MBL2
19plasmacytoma30.0BCL6, IGH, TNFRSF8
20t-cell leukemia30.0TNFRSF8, IGH, MYB, ERVW-1, LGALS1, BCL2
21b-cell chronic lymphocytic leukemia29.8BCL2, IGH
22hepatitis b29.8MBL2, TNFRSF8, MYB, DNMT1, GSR
23retinoblastoma29.8BMI1, MYB, DNMT1, BCL2, SMARCA4
24lung cancer29.8SMARCA4, BCL2, LGALS1, DNMT1
25breast cancer29.8BMI1, DNMT1, ERVW-1, LGALS1, BCL2
26adenoma29.8TNFRSF8, DNMT1, LGALS1, BCL2, SMARCA4, GSR
27sarcoma29.7LGALS1, ERVW-1
28pancreatitis29.7ASRGL1, H6PD
29thyroiditis29.7MBL2
30stomach cancer29.7BCL2, DNMT1, MBL2
31myeloid leukemia29.7BMI1, MYB, DNMT1, BCL2
32chronic myeloid leukemia29.7BCL2, DNMT1, MYB, BMI1
33chronic lymphocytic leukemia29.7BCL2, BCL6, MYB, IGH
34acute lymphocytic leukemia29.7IGH, MYB, CD22, BCL6, BCL2
35adenocarcinoma29.7MYB, DNMT1, ERVW-1, LGALS1, BCL2, SMARCA4
36melanoma29.7BMI1, MYB, DNMT1, LGALS1, BCL2, SMARCA4
37bone lymphoma10.6
38bladder lymphoma10.5
39thyroid lymphoma10.5
40breast lymphoma10.5
41mediastinal malignant lymphoma10.4
42heart lymphoma10.4
43hypercalcemia10.3
44lung lymphoma10.3
45small intestine lymphoma10.3
46appendix lymphoma10.2
47adult lymphoma10.2
48histiocytosis10.2
49mediastinitis10.2
50rectum lymphoma10.2

Graphical network of the top 20 diseases related to Lymphosarcoma:



Diseases related to lymphosarcoma

Clinical Features for Lymphosarcoma

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Drugs & Therapeutics for Lymphosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lymphosarcoma

Drug clinical trials:

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Search NIH Clinical Center for Lymphosarcoma

Search CenterWatch for Lymphosarcoma

Genetic Tests for Lymphosarcoma

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Anatomical Context for Lymphosarcoma

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32MalaCards
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MalaCards organs/tissues related to Lymphosarcoma:

32
Bone marrow, Spleen, Bone, Lymph node, T cells, Liver, Lung, B cells, Colon, Thyroid, Testes, Skin, Brain, Spinal cord, Uterus, Cervix, Tongue, Myeloid, Breast, Heart, Thymus, Trachea, Skeletal muscle

Animal Models for Lymphosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lymphosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.8MTF1, MYB, DNMT1, DNMT3A, CD22, BCL6
2MP:00053978.2MTF1, BMI1, TNFRSF8, MBL2, MYB, DNMT1
3MP:00053878.1SMARCA4, MBL2, TNFRSF8, BMI1, MTF1, MYB

Publications for Lymphosarcoma

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50PubMed
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Articles related to Lymphosarcoma:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Dynamics of oxidative modification of proteins and specific structural features of blood plasma from animals with Pliss lymphosarcoma. (23658922)
2013
2
The Toxic Effects of Polychemotherapy onto the Liver Are Accelerated by the Upregulated MDR of Lymphosarcoma. (23251817)
2012
3
Thymic lymphosarcoma with brain involvement in a Holstein heifer. (22785125)
2012
4
What is your diagnosis? Lymphosarcoma. (22216725)
2011
5
Specifically activated dendritic cells--cell-based vaccine against lymphosarcoma exhibiting multiple drug resistance phenotype. (20848912)
2009
6
A case of bilateral renal lymphosarcoma with secondary polycythaemia and paraneoplastic syndromes of hypoglycaemia and uveitis in an English Springer Spaniel. (19754769)
2005
7
Theriogenology question of the month. Lymphosarcoma infiltrating the uterus, cervix, and vagina. (15154726)
2004
8
Therapy for Australian cats with lymphosarcoma. (11837901)
2001
9
T cell-rich B cell lymphosarcoma in the tongue of a horse. (10609574)
1999
10
Identification and localization of steroid-binding and nonsteroid-binding forms of the glucocorticoid receptor in the mouse P1798 lymphosarcoma. (7748809)
1995
11
Feline spinal lymphosarcoma: a retrospective evaluation of 23 cats. (8046683)
1994
12
A needle aspirate as an aid to diagnosis of lymphosarcoma in a guinea pig. (8236727)
1993
13
Vertebral lymphosarcoma as the cause of hind limb paresis in a horse. (2488341)
1989
14
Splenic lymphosarcoma in a ferret. (17423382)
1989
15
Translational initiation factor expression and ribosomal protein gene expression are repressed coordinately but by different mechanisms in murine lymphosarcoma cells treated with glucocorticoids. (2779563)
1989
16
The effect of GD3 ganglioside obtained from bovine lymphosarcoma on bovine normal mononuclear cell. (2615676)
1989
17
Cyclosporin A inhibits rDNA transcription in lymphosarcoma P1798 cells. (3680246)
1987
18
Regression of lymphosarcoma by treatment with acetylsalicylic acid in rats. (3867066)
1985
19
Cryotherapy of cutaneous lymphosarcoma in a German shepherd. (6548290)
1984
20
Lymphosarcoma and persistent feline leukemia virus infection of pet cats: a system to study responses during extracorporeal treatments. (6086847)
1984
21
Involvement of cell-cell adhesion molecules in liver colonization by metastatic murine lymphoma/lymphosarcoma variants. (6549550)
1984
22
Possible viral etiology of childhood acute lymphosarcoma-cell leukaemia in Kenya. (6100287)
1984
23
Lymphosarcoma with perforation of the ileum in a grizzly bear. (6548998)
1984
24
Equine lymphosarcoma. (6547125)
1984
25
Treatment of C3H mice bearing solid Gardner lymphosarcoma with vaccine prepared from Corynebacterium parvum combined with methotrexate and Alexan. (6549500)
1984
26
Differences in surface expression of WGA-binding proteins of cells from a lymphosarcoma and its liver metastases. (6546519)
1984
27
Glycosaminoglycans of solid and ascites forms of the P1798 murine lymphosarcoma. (6688525)
1983
28
Activation of a cyclic AMP-independent protein kinase by an endogenous ATP-requiring protease from lymphosarcoma cells. (6300081)
1983
29
Lymphosarcoma cell leukemia and other non-Hodgkin's lymphomas in leukemic phase. (6344632)
1983
30
The radiosensitivity of lymphosarcoma cells as determined by the liver colony method. (6689593)
1983
31
Cytochemical reactions in bovine and ovine lymphosarcoma. (6308878)
1983
32
Lymphosarcoma in an aborted equine fetus. (6688898)
1983
33
Chemotherapeutic responses in dogs with lymphosarcoma and hypercalcemia. (6897239)
1982
34
Lymphocyte blastogenesis in dogs with lymphosarcoma. (6896408)
1982
35
Feline lymphosarcoma with cutaneous and muscle lesions--. (6896871)
1982
36
Infiltration of lymphosarcoma cells into hepatocyte cultures: inhibition by univalent antibodies against liver plasma membranes and lymphosarcoma cells. (7166577)
1982
37
Metastatic RAW117 lymphosarcoma as a model for malignant-normal cell interactions. Possible roles for cell surface antigens in determining the quantity and location of secondary tumors. (6897445)
1982
38
Subfractionation of malignant variants of metastatic murine lymphosarcoma cells by countercurrent distribution in two-polymer aqueous phases. (6895470)
1981
39
Proteins associated with emergence of the resistance to lethal glucocorticoid actions in P1798 mouse lymphosarcoma cells. (6894886)
1981
40
Characterization of X-tropic endogenous retrovirus-specific RNA uninfected tissues and lymphosarcoma of BALB/c mice. (6255075)
1980
41
Effect of the alpha globulin fraction on the survival time of C3H mice (C3H/Sumice and C3H/VUFB) with a solid Gardner lymphosarcoma. (6160062)
1980
42
Lymphosarcoma and blockage of the biliary duct in an African lion (Panthera leo). (260524)
1979
43
Primary lymphosarcoma of lung associated with hypertrophic pulmonary osteoarthropathy. (582631)
1979
44
Total-body irradiation in advanced lymphosarcoma. (111751)
1979
45
Relationship between lymphosarcoma and persistent lymphocytosis in cattle: a review. (231027)
1979
46
Selection and biologic properties of malignant variants of a murine lymphosarcoma. (281557)
1978
47
Preliminary results of chemo-radiotherapy followed or not by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma. Correlation of the results with WHO categorisation. (373920)
1978
48
Subacute thyroiditis associated with lymphosarcoma of the thyroid. (1173065)
1975
49
Cytogenetic analysis in two cases of lymphoma. Comparison between lymphosarcoma and reticulosarcoma. (4910257)
1970
50
Cytomegalic inclusion disease in children with leukemia or lymphosarcoma. (13900765)
1962

Genetic Variations for Lymphosarcoma

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Expression for genes affiliated with Lymphosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lymphosarcoma

Search GEO for disease gene expression data for Lymphosarcoma.

Pathways for genes affiliated with Lymphosarcoma

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12EMD Millipore, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Pathways related to Lymphosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0DNMT3A, DNMT1, BMI1
29.8DNMT3A, LGALS1, BCL2
39.8BCL2, DNMT3A, DNMT1, BMI1
49.7SMARCA4, DNMT3A, DNMT1, BMI1
59.6BCL6, LGALS1, MYB, BMI1

Compounds for genes affiliated with Lymphosarcoma

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 28IUPHAR
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Compounds related to Lymphosarcoma according to GeneCards/GeneDecks:

(show all 44)
idCompoundScoreTop Affiliating Genes
1butyrate4410.5MYB
2zebularine4410.5DNMT1, DCTD
3cycloheximide4410.5MTF1
4o-ethylhydroxylamine4410.5GSR, H6PD
5estrogen4410.5BCL6, MBL2
6no-dimethylhydroxylamine4410.5GSR, H6PD
73-deazaneplanocin a hydrochloride5910.4DNMT1, DNMT3A
8unc 06465910.4DNMT1, DNMT3A
9unc 06385910.4DNMT1, DNMT3A
10bix 012945910.4DNMT1, DNMT3A
11sgc 09465910.4DNMT1, DNMT3A
122-chlorodeoxyadenosine4410.4DCTD, DNMT1, BCL2
13serine4410.3MTF1, ERVW-1
14dihydrofolate4410.3H6PD, DNMT1, SMARCA4
15cytidine44 11 2412.2BCL6, DNMT1, DCTD
16imatinib44 49 1112.1MYB, DNMT1, BCL6, BCL2
17cadmium44 2411.1MTF1, DNMT1, SMARCA4
18folate4410.1H6PD, DNMT1, DNMT3A, GSR
19cyclophosphamide44 49 1112.0MBL2, BCL6, BCL2, GSR
20retinoid4410.0MYB, DNMT1, LGALS1, BCL2
21cytosine44 2411.0DNMT3A, DNMT1, MYB
22monosaccharide4410.0LGALS1, MBL2
23doxorubicin44 49 1111.9GSR, BCL2, BCL6, DNMT1, MYB
24tuberculin449.9MBL2, TNFRSF8
25galactose449.8H6PD, MBL2, LGALS1
26agarose449.8MBL2, IGH, LGALS1, BCL2
27fructose-1,6-bisphosphate449.8GSR, H6PD
28glyceraldehyde 3-phosphate449.8H6PD, ERVW-1, LGALS1, GSR
29agar449.8DNMT1, ERVW-1, LGALS1, SMARCA4
30progesterone44 59 28 11 2413.7MBL2, MYB, DNMT1, BCL2, SMARCA4
31adenylate449.7H6PD, MYB, DNMT1, ASRGL1, GSR
32methionine449.7LGALS1, ERVW-1, DNMT1, MYB
33superoxide44 2410.7H6PD, MBL2, MTF1, LGALS1, GSR
34paraffin449.7MBL2, TNFRSF8, LGALS1, BCL6, BCL2
35polysaccharide449.7H6PD, MBL2, CD22, ERVW-1, LGALS1
36h2o2449.7GSR, BCL2, MYB, MTF1, H6PD
37steroid449.6H6PD, MBL2, MYB, DNMT1, ERVW-1, SMARCA4
38polyacrylamide449.6H6PD, IGH, ERVW-1, LGALS1
39oxygen44 2410.5MBL2, MTF1, MYB, DNMT1, ERVW-1, LGALS1
40oligonucleotide449.1IGH, MYB, DNMT1, DNMT3A, CD22, ERVW-1
41lipid449.0H6PD, MBL2, TNFRSF8, MYB, ERVW-1, LGALS1
42cysteine448.9H6PD, MBL2, MTF1, MYB, DNMT1, ERVW-1
43tyrosine448.6MBL2, TNFRSF8, MTF1, MYB, DNMT1, CD22
44zinc44 249.6SMARCA4, H6PD, MBL2, TNFRSF8, BMI1, MTF1

GO Terms for genes affiliated with Lymphosarcoma

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16Gene Ontology
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Cellular components related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:00565710.1BCL6, DNMT1

Biological processes related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA methylationGO:00630610.1DNMT3A, DNMT1
2DNA methylation on cytosine within a CG sequenceGO:01042410.1SMARCA4, DNMT3A
3positive regulation of histone H3-K4 methylationGO:05157110.1DNMT1, MYB
4methylation-dependent chromatin silencingGO:00634610.1DNMT3A, SMARCA4
5negative regulation of cell growthGO:0303089.5SMARCA4, BCL2, BCL6
6negative regulation of transcription from RNA polymerase II promoterGO:0001229.4SMARCA4, BCL6, DNMT3A, DNMT1, MYB, BMI1

Molecular functions related to Lymphosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA (cytosine-5-)-methyltransferase activityGO:00388610.0DNMT3A, DNMT1
2chromatin bindingGO:0036829.3MYB, DNMT3A, BCL6, SMARCA4
3protein bindingGO:0055158.0BMI1, MTF1, AGAP2, MYB, DNMT1, DNMT3A

Products for genes affiliated with Lymphosarcoma

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Sources for Lymphosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet