Lynch Syndrome disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

COCA1 MCID: LYN001 MIFTS: 70	Lynch Syndrome (COCA1) malady Gastrointestinal diseases, Cancer diseases, Genetic diseases categories
107 genes, 14 tissues, 118 related diseases, clinical trials, genetic tests.

Summaries for Lynch Syndrome

Sources:
²¹Genetics Home Reference, ⁴²NIH Rare Diseases, ⁶³Wikipedia, ⁴⁶OMIM, ¹⁹GeneReviews, ³²MalaCards
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Genetics Home Reference:²¹ Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, and skin. Additionally, women with this disorder have a high risk of cancer of the ovaries and lining of the uterus (the endometrium). People with Lynch syndrome may occasionally have noncancerous (benign) growths (polyps) in the colon, called colon polyps. In individuals with this disorder, colon polyps occur earlier but not in greater numbers than they do in the general population.

MalaCards: Lynch Syndrome, also known as hereditary nonpolyposis colorectal cancer, is related to colorectal cancer and adenoma. An important gene associated with Lynch Syndrome is PMS1 (PMS1 postmeiotic segregation increased 1 (S. cerevisiae)), and among its related pathways are Lagging Strand Synthesis and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds crcs and paraffin have been mentioned in the context of this disorder. Affiliated tissues include colon, brain and skin, and related mouse phenotypes are tumorigenesis and cellular.

NIH Rare Diseases:⁴² Lynch syndrome is an inherited condition that causes an increased risk of developing cancer. individuals with lynch syndrome have a higher risk of developing colon and rectal cancer, as well as cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, skin, and prostate. women with lynch syndrome also have a high risk of developing uterine cancer (also called endometrial cancer) and ovarian cancer. even though the disorder was originally described as not involving noncancerous (benign) growths (polyps) in the colon, people with lynch syndrome may occasionally have colon polyps. lynch syndrome has an autosomal dominant pattern of inheritance and is caused by a mutation in the mlh1, msh2, msh6, pms2 or epcam gene. last updated: 10/18/2013

Wikipedia:⁶³ Lynch syndrome (HNPCC or hereditary nonpolyposis colorectal cancer ) is an autosomal dominant genetic... more...

Description from OMIM:⁴⁶ 613244,120435,609310

GeneReviews summary for hnpcc

Aliases & Classifications for Lynch Syndrome

Sources:
⁸Disease Ontology, ⁶³Wikipedia, ¹⁹GeneReviews, ⁴²NIH Rare Diseases, ²⁰GeneTests, ²²GTR, ²¹Genetics Home Reference, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ⁴⁶OMIM, ⁵⁶SNOMED-CT, ³⁴MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Gastrointestinal diseases

Aliases & Descriptions:

lynch syndrome ⁸ ⁶³ ¹⁹ ⁴² ²⁰ ²² ²¹ ¹⁰ ⁴⁴

hereditary nonpolyposis colorectal cancer ⁸ ⁶³ ⁴² ²¹ ⁶⁰

familial nonpolyposis colon cancer ⁶³ ⁴² ²¹

hnpcc ⁶³ ¹⁹ ²¹

colon cancer, familial nonpolyposis ⁶³ ⁴²

cancer family syndrome ⁶³ ²¹

colorectal cancer, hereditary nonpolyposis, type 1 ⁶⁰

hereditary defective mismatch repair syndrome ⁸

hereditary non-polyposis colon cancer type 1 ⁸

hnpcc - hereditary nonpolyposis colon cancer ⁸

hereditary nonpolyposis colorectal neoplasms ²¹

hereditary nonpolyposis colorectal neoplasm ⁸

colorectal cancer, hereditary nonpolyposis ⁴²

hereditary non-polyposis colon cancer ¹⁹

hereditary nonpolyposis colon cancer ⁴⁴

lynch cancer family syndrome 2 ⁶⁰

coca 1 ⁸

coca1 ⁴²

External Ids:

Disease Ontology⁸ DOID:3883

OMIM⁴⁶ 613244, 120435, 609310

SNOMED-CT⁵⁶ 315058005

MeSH³⁴ D003123

UMLS⁶⁰ C1333990, C0009405

Related Diseases for Lynch Syndrome

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Lynch Syndrome family:

Mlh1-Related Lynch Syndrome	Msh2-Related Lynch Syndrome
Msh6-Related Lynch Syndrome	Pms2-Related Lynch Syndrome
Epcam-Related Lynch Syndrome	Mlh3-Related Lynch Syndrome
Pms1-Related Lynch Syndrome

Diseases related to Lynch Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 118)

id	Related Disease	Score	Top Affiliating Genes
1	colorectal cancer	31.5	PMS1, PMS2, BRAF, APC, MLH1, MUTYH
2	adenoma	30.8	APC, BRAF, BRCA1, MLH1, MUTYH, MSH6
3	colon cancer	30.7	APC, BRAF, MSH2, EPCAM, MLH1, MSH6
4	breast cancer	30.6	MSH2, EPCAM, MSH6, BRCA1, BRCA2
5	adenocarcinoma	30.6	PMS2, MSH2, BRCA1, EPCAM, BRAF, XRCC3
6	familial adenomatous polyposis	30.6	PMS2, PMS1, MSH2, BRCA1, MSH6, MUTYH
7	ovarian cancer	30.6	MSH2, EPCAM, MLH1, BRAF, BRCA2, BRCA1
8	prostate cancer	30.5	PMS1, PMS2, BRCA1, BRCA2, APC, LIG4
9	endometrial carcinoma	30.5	BRCA2, MSH2, MLH1, BRAF, BRCA1, MSH6
10	melanoma	30.4	MSH2, EPCAM, PMS1, PMS2, RNASE1, BRCA2
11	retinoblastoma	30.4	PMS1, BRCA1, APC, CDKN2B, BRCA2, EPCAM
12	male breast cancer	30.4	BRCA2, BRCA1
13	gastric cancer, somatic	30.4	MUTYH, APC
14	muir-torre syndrome	30.4	MSH6, MLH1, C3orf35, MSH2
15	pancreatic cancer	30.2	MSH2, RNASE1, EPCAM, MLH1, BRAF, BRCA2
16	pancreatitis	30.2	BRCA2, RNASE1
17	turcot syndrome	30.2	PMS2, MLH1
18	transitional cell carcinoma	30.2	MLH1, CDKN2B, MSH2
19	neurofibromatosis	30.1	MSH2, MLH1, BRCA2, PMS2, MSH6
20	thyroid cancer	29.9	BRAF, APC
21	li-fraumeni syndrome	29.9	BRCA1, MLH1, BRCA2
22	hepatocellular carcinoma	29.9	APC, EPCAM, CDKN2B, MUTYH, BRCA2
23	brca1 and brca2 hereditary breast and ovarian cancer	29.9	BRCA1, BRCA2
24	brain cancer	29.9	CDKN2B, APC, MSH2, MSH6
25	oligodendroglioma	29.9	BRAF, CDKN2B
26	sarcoma	29.9	MLH1, MSH2, BRCA2, BRAF
27	hematologic cancer	29.9	MSH2, MLH1, CDKN2B, MSH6
28	keratoacanthoma	29.9	MSH2, MLH1
29	colorectal cancer, hereditary nonpolyposis, type 8	10.5
30	colorectal cancer, hereditary nonpolyposis, type 5	10.5
31	colorectal cancer, hereditary nonpolyposis, type 6	10.5
32	colorectal cancer, hereditary nonpolyposis, type 2	10.5
33	colorectal cancer, hereditary nonpolyposis, type 4	10.5
34	colorectal cancer, hereditary nonpolyposis, type 7	10.5
35	prostatitis	10.4
36	non-hodgkin lymphoma	10.3
37	hereditary hemorrhagic telangiectasia	10.3
38	lymphoepithelioma-like carcinoma	10.3
39	uterine carcinosarcoma	10.3
40	duodenitis	10.3
41	liposarcoma	10.3
42	pleomorphic rhabdomyosarcoma	10.3
43	rhabdomyosarcoma	10.3
44	ciliary dyskinesia, primary, 27	10.3
45	colorectal cancer, hereditary nonpolyposis, type 1	10.3
46	hereditary breast ovarian cancer	10.1
47	endometriosis	10.1
48	peritonitis	10.1
49	mlh1-related lynch syndrome	10.1
50	msh2-related lynch syndrome	10.1

Graphical network of the top 20 diseases related to Lynch Syndrome:

Clinical Features for Lynch Syndrome

Sources:
⁴⁶OMIM
See all sources

Clinical features from OMIM:

613244,120435,609310

Drugs & Therapeutics for Lynch Syndrome

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Lynch Syndrome

Drug clinical trials:

Search ClinicalTrials for Lynch Syndrome

Search NIH Clinical Center for Lynch Syndrome

Search CenterWatch for Lynch Syndrome

Genetic Tests for Lynch Syndrome

Sources:
²⁰GeneTests, ²²GTR
See all sources

Genetic tests related to Lynch Syndrome:

id	Genetic test	Affiliating Genes
1	Lynch Syndrome²⁰ ²²

Anatomical Context for Lynch Syndrome

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Lynch Syndrome:

³²

Colon, Brain, Skin, Small intestine, Testes, Ovary, Liver, Prostate, Uterus, Breast, Kidney, Thyroid, Lung, Pancreas

Animal Models for Lynch Syndrome or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Lynch Syndrome:

³⁶ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	10.7	MSH2, PMS1, PMS2, BRAF, MLH1, CDKN2B
2	cellular phenotype	MP:0005384	10.7	APC, XRCC2, BRAF, BRCA2, BRCA1, PMS2
3	mortality/aging	MP:0010768	10.7	APC, XRCC2, BRAF, BRCA2, BRCA1, PMS2
4	integument phenotype	MP:0010771	10.6	BRCA1, BRCA2, XRCC2, APC, E2F2, CDKN2B
5	homeostasis/metabolism phenotype	MP:0005376	10.6	PMS2, BRCA1, BRCA2, XRCC2, LIG4, MUTYH
6	digestive/alimentary phenotype	MP:0005381	10.6	PMS2, BRCA1, BRCA2, BRAF, APC, MLH1
7	hematopoietic system phenotype	MP:0005397	10.5	PMS2, BRCA1, BRCA2, BRAF, APC, E2F2
8	endocrine/exocrine gland phenotype	MP:0005379	10.5	PMS2, BRCA1, BRCA2, MLH1, MLH3, CDKN2B
9	nervous system phenotype	MP:0003631	10.5	EPCAM, MUTYH, LIG4, APC
10	immune system phenotype	MP:0005387	10.4	PMS2, BRCA1, BRCA2, BRAF, APC, E2F2
11	reproductive system phenotype	MP:0005389	10.2	BRCA1, BRCA2, BRAF, APC, MLH1, MLH3

Publications for Lynch Syndrome

Sources:
⁵⁰PubMed
See all sources

Articles related to Lynch Syndrome:

(show top 50) (show all 563)

id	Title	Authors	Year
1	Prostate cancer incidence in males with Lynch syndrome. (24434690)	Haraldsdottir S.... Goldberg R.M.	2014
2	Germline mutation and protein expression analysis of mismatch repair genes MSH6 and PMS2 in Malaysian Lynch syndrome patients. (24072394)	Zahary M.N.... Ankathil R.	2014
3	Value-based healthcare in Lynch syndrome. (23681793)	Hennink S.D.... Vasen H.F.	2013
4	New genetic variants of genes MMR in a Spanish family with Lynch syndrome. (23224667)	MartA-n Ruiz J.L.... Entrala Bernal C.	2013
5	Chemoprevention in Lynch syndrome. (23880960)	Burn J.... Bishop D.T.	2013
6	Mutation spectrum in South American Lynch syndrome families. (24344984)	Dominguez-Valentin M.... Rossi B.M.	2013
7	Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families. (23414081)	Burton-Chase A.M.... Gritz E.R.	2013
8	Surveillance for urinary tract cancer in Lynch syndrome. (23700068)	Bernstein I.T.... j T.	2013
9	Genotype-phenotype correlation in MMR mutation-positive families with Lynch syndrome. (23588873)	PAcrez-Cabornero L.... DurA!n M.	2013
10	Immunochemistry screening for Lynch syndrome in colorectal adenocarcinoma using an initial two antibody panel can replace a four antibody panel. (24154771)	O'Regan T.... Bissett I.	2013
11	Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study. (23512527)	Aktan-Collan K.... Haukkala A.	2013
12	Gene variants of unknown clinical significance in Lynch syndrome. An introduction for clinicians. (23525798)	Sijmons R.H.... Genuardi M.	2013
13	Evaluation of predictive models in daily practice for the identification of patients with Lynch syndrome. (21520036)	Tresallet C.... Hofmann-Radvanyi H.	2012
14	The molecular basis of EPCAM expression loss in Lynch syndrome-associated tumors. (22388758)	Huth C.... BlAoker H.	2012
15	Lynch syndrome diagnostics: decision-making process for germ-line testing. (22484632)	Lastra E.... GarcA-a-GirA^n C.	2012
16	Endometrioid adenocarcinoma arising from colonic endometriosis in a Lynch syndrome patient. (21698352)	Chen P.C.... Lee J.C.	2012
17	Novel germline MLH1 and MSH2 mutations in Latvian Lynch syndrome families. (22453149)	BA9rziA8a D.... MiklaA!eviA8s E.	2012
18	Reflex immunohistochemistry and microsatellite instability testing of colorectal tumors for Lynch syndrome among US cancer programs and follow-up of abnormal results. (22355048)	Beamer L.C.... Macdonald D.J.	2012
19	A case of endometrial cancer in the context of a BRCA2 mutation and double heterozygosity for Lynch syndrome. (24371622)	Gong P.... Witkiewicz A.K.	2012
20	Screening for Lynch syndrome in colorectal cancer: are we doing enough? (21879275)	Canard G.... Parc Y.	2012
21	MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study. (22274583)	Gausachs M.... CapellA! G.	2012
22	Influence of patient preferences on the cost-effectiveness of screening for lynch syndrome. (22942831)	Wang G.... Ladabaum U.	2012
23	Lynch syndrome screening in newly diagnosed colorectal cancer in general pathology practice: from the revised Bethesda guidelines to a universal approach. (21879804)	Morrison J.... Liu X.	2011
24	A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families. (21785361)	Pinheiro M.... Teixeira M.R.	2011
25	Recurrence and variability of germline EPCAM deletions in Lynch syndrome. (21309036)	Kuiper R.P.... Ligtenberg M.J.	2011
26	Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome. (20857224)	Aktan-Collan K.I.... Mecklin J.P.	2011
27	Alu in Lynch syndrome: a danger SINE? (21972078)	Hitchins M.P.... Burn J.	2011
28	Characterization of germline mutations of MLH1 and MSH2 in unrelated south American suspected Lynch syndrome individuals. (21681552)	Valentin M.D.... Rossi B.M.	2011
29	Building a tool to identify risk for Lynch syndrome among individuals presenting for screening colonoscopy. (20349120)	Rabinowitz-Abrams D.... Miesfeldt S.	2010
30	Magnetic resonance colonography for colorectal cancer screening in patients with Lynch syndrome gene mutation. (20495877)	Lim E.J.... Macrae F.	2010
31	One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome. (20206180)	Vasen H.F.... Nagengast F.M.	2010
32	Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families. (20937110)	Thodi G.... Yannoukakos D.	2010
33	Hereditary breast and ovarian cancer (HBOC): clinical features and counseling for BRCA1 and BRCA2, Lynch syndrome, Cowden syndrome, and Li-Fraumeni syndrome. (20494261)	Shulman L.P.	2010
34	Diagnosis and management of hereditary colorectal cancer syndromes: Lynch syndrome as a model. (19654196)	Lynch H.T.... Attard T.A.	2009
35	Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. (19659756)	Lynch H.T.... Boland C.R.	2009
36	Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome. (19156873)	Ou J.... Hofstra R.M.	2009
37	Early-onset breast cancer in a Lebanese family with Lynch syndrome due to MSH2 gene mutation. (19476642)	Akoum R.... Hajjar N.	2009
38	Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome. (19728162)	Gargiulo S.... Ghiorzo P.	2009
39	Estrogens, MSI and Lynch syndrome-associated tumors. (19559756)	Ferreira A.M.... Hofstra R.M.	2009
40	Intraductal papillary mucinous neoplasm of the pancreas with loss of mismatch repair in a patient with Lynch syndrome. (18987546)	Sparr J.A.... Syngal S.	2009
41	EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. (19125127)	Palomaki G.E.... Thibodeau S.N.	2009
42	Lynch syndrome in women less than 50 years of age with endometrial cancer. (18448750)	Matthews K.S.... Rocconi R.P.	2008
43	A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome. (18178629)	Clendenning M.... de la Chapelle A.	2008
44	Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. (17312306)	Lagerstedt Robinson K.... Lindblom A.	2007
45	Immunohistochemical expression and microsatellite instability in Lynch syndrome]. (17628916)	Vaccaro C.A.... Redal M.A.	2007
46	Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer. (17925543)	Lu K.H.... Broaddus R.R.	2007
47	Some aspects of molecular diagnostics in Lynch syndrome. (20223024)	Kurzawski G.	2006
48	Characterization of hMLH1 and hMSH2 gene dosage alterations in Lynch syndrome patients. (16143124)	Baudhuin L.M.... Thibodeau S.N.	2005
49	Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? (16361634)	Soliman P.T.... Lu K.H.	2005
50	Detection mutations in the DNA mismatch repair genes of hMLH1 and hMSH2 genes in Colombian families with suspicion of hereditary non-polyposis colorectal carcinoma (Lynch syndrome)]. (16276679)	GA^mez A.... Giraldo A.	2005

Genes related to Lynch Syndrome

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Lynch Syndrome:

(show top 50) (show all 107)

id	Symbol	Description	Score	Implication
1	PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	20.11	GeneCards inferred : Publications, Disorders, Summaries (show sections)
2	MLH1	mutL homolog 1	19.91	GeneCards inferred : Publications, Disorders (show sections)
3	MSH2	mutS homolog 2	19.72	GeneCards inferred : Publications, Disorders (show sections)
4	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	19.53	GeneCards inferred : Publications, Disorders (show sections)
5	MSH6	mutS homolog 6	19.35	GeneCards inferred : Publications, Disorders (show sections)
6	BRCA2	breast cancer 2, early onset	19.16	GeneCards inferred : Publications, Disorders (show sections)
7	BRCA1	breast cancer 1, early onset	18.97	GeneCards inferred : Disorders (show sections)
8	EPCAM	epithelial cell adhesion molecule	18.78	GeneCards inferred : Publications, Disorders (show sections)
9	MLH3	mutL homolog 3	18.60	GeneCards inferred : Publications, Disorders (show sections)
10	BRAF	v-raf murine sarcoma viral oncogene homolog B	18.41	GeneCards inferred : Publications, Disorders (show sections)
11	MUTYH	mutY homolog	18.22	GeneCards inferred : Disorders (show sections)
12	APC	adenomatous polyposis coli	18.04	GeneCards inferred : Publications, Disorders (show sections)
13	LIG4	ligase IV, DNA, ATP-dependent	17.84	GeneCards inferred : Publications, Disorders (show sections)
14	XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	17.66	GeneCards inferred : Publications, Disorders (show sections)
15	XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	17.47	GeneCards inferred : Publications, Disorders (show sections)
16	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	17.28	GeneCards inferred : Publications, Disorders (show sections)
17	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	17.10	GeneCards inferred : Publications, Disorders (show sections)
18	E2F2	E2F transcription factor 2	16.91	GeneCards inferred : Publications, Disorders (show sections)
19	RNASE1	ribonuclease, RNase A family, 1 (pancreatic)	16.72	GeneCards inferred : Publications, Disorders (show sections)
20	C3orf35	chromosome 3 open reading frame 35	16.54	GeneCards inferred : Disorders (show sections)
21	LRRFIP2	leucine rich repeat (in FLII) interacting protein 2	16.35	GeneCards inferred : Publications, Disorders (show sections)
22	MSH3	mutS homolog 3	16.16	GeneCards inferred : Publications, Disorders (show sections)
23	REEP5	receptor accessory protein 5	15.98	GeneCards inferred : Disorders (show sections)
24	AURKA	aurora kinase A	15.79	GeneCards inferred : Publications, Disorders (show sections)
25	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	15.60	GeneCards inferred : Publications, Disorders (show sections)
26	OGG1	8-oxoguanine DNA glycosylase	15.41	GeneCards inferred : Publications, Disorders (show sections)
27	EPHX1	epoxide hydrolase 1, microsomal (xenobiotic)	15.23	GeneCards inferred : Publications, Disorders (show sections)
28	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	15.04	GeneCards inferred : Publications, Disorders (show sections)
29	GOLGA4	golgin A4	14.85	GeneCards inferred : Publications, Disorders (show sections)
30	MDM2	MDM2 oncogene, E3 ubiquitin protein ligase	14.67	GeneCards inferred : Publications, Disorders (show sections)
31	GSTP1	glutathione S-transferase pi 1	14.48	GeneCards inferred : Publications, Disorders (show sections)
32	KRAS	Kirsten rat sarcoma viral oncogene homolog	14.29	GeneCards inferred : Publications, Disorders (show sections)
33	MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	14.11	GeneCards inferred : Publications, Disorders (show sections)
34	GSTT1	glutathione S-transferase theta 1	13.92	GeneCards inferred : Publications, Disorders (show sections)
35	RAD50	RAD50 homolog (S. cerevisiae)	13.73	GeneCards inferred : Publications, Disorders (show sections)
36	NBN	nibrin	13.55	GeneCards inferred : Publications, Disorders (show sections)
37	FASLG	Fas ligand (TNF superfamily, member 6)	13.36	GeneCards inferred : Publications, Disorders (show sections)
38	TP73	tumor protein p73	13.17	GeneCards inferred : Publications, Disorders (show sections)
39	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	12.98	GeneCards inferred : Disorders (show sections)
40	CDKN2A	cyclin-dependent kinase inhibitor 2A	12.80	GeneCards inferred : Publications, Disorders (show sections)
41	EXO1	exonuclease 1	12.61	GeneCards inferred : Disorders (show sections)
42	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	12.42	GeneCards inferred : Publications, Disorders (show sections)
43	COMT	catechol-O-methyltransferase	12.24	GeneCards inferred : Publications, Disorders (show sections)
44	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1	12.05	GeneCards inferred : Publications, Disorders (show sections)
45	GSTM1	glutathione S-transferase mu 1	11.86	GeneCards inferred : Publications, Disorders (show sections)
46	FAS	Fas cell surface death receptor	11.68	GeneCards inferred : Publications, Disorders (show sections)
47	CCND1	cyclin D1	11.49	GeneCards inferred : Publications, Disorders (show sections)
48	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.30	GeneCards inferred : Publications, Disorders (show sections)
49	MGMT	O-6-methylguanine-DNA methyltransferase	11.12	GeneCards inferred : Publications, Disorders (show sections)
50	ITGA9	integrin, alpha 9	10.93	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Lynch Syndrome disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	48	48	50
2	LSBio	-	-	50

Genetic Variations for Lynch Syndrome

Expression for genes affiliated with Lynch Syndrome

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Lynch Syndrome

Search GEO for disease gene expression data for Lynch Syndrome.

Pathways for genes affiliated with Lynch Syndrome

Sources:
⁵³Reactome, ³⁷NCBI BioSystems Database, ⁵¹QIAGEN, ²⁹KEGG, ¹²EMD Millipore, ⁴Cell Signaling Technology
See all sources

Pathways related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 21)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Lagging Strand Synthesis⁵³ Hide members Mismatch repair³⁷ Mismatch Repair in Eukaryotes⁵¹ Mismatch repair²⁹	10.5	MSH2, PMS1, PMS2, MLH1, MLH3, MSH6
2	DNA damage Role of Brca1 and Brca2 in DNA repair Hide members DNA damage Role of Brca1 and Brca2 in DNA repair¹²	10.5	BRCA1, BRCA2, MLH1, MSH6, MSH2
3	DNA Damage⁴ Hide members Cell Cycle / Checkpoint Control⁴	10.5	BRCA1, BRCA2, MLH1, MUTYH, MSH6, MSH2
4	Fanconi anemia pathway²⁹	10.5	PMS2, BRCA1, BRCA2, MLH1
5	Direct p53 effectors³⁷	10.5	MSH2, MLH1, APC, PMS2
6	Prostate Cancer³⁷ Hide members Integrated Cancer pathway³⁷	10.5	BRCA1, MSH6, MSH2
7	Meiotic Synapsis⁵³ Hide members Meiotic Recombination⁵³ Meiosis⁵³ Chromosome Maintenance⁵³	10.5	BRCA1, BRCA2, MLH1, MLH3
8	Endometrial cancer²⁹ Hide members Colorectal cancer²⁹ Acute myeloid leukemia²⁹	10.5	BRAF, APC, MLH1, MSH6, MSH2
9	Integrated Breast Cancer Pathway³⁷	10.5	BRCA1, BRCA2, BRAF, XRCC3, MSH6, MSH2
10	BRCA1 Pathway⁵¹	10.5	BRCA1, BRCA2, E2F2, MSH6, MSH2
11	Homologous Recombination Repair⁵³ Hide members Double-Strand Break Repair⁵³ Homologous recombination repair of replication-independent double-strand breaks⁵³	10.5	BRCA1, BRCA2, LIG4
12	Colorectal Cancer Metastasis⁵¹	10.5	MSH6, APC, BRAF
13	Chks in Checkpoint Regulation⁵¹ Hide members DNA Repair Mechanisms⁵¹ Estrogen-mediated S-Phase Entry⁵¹	10.5	BRCA1, BRCA2, E2F2, LIG4, MSH6, MSH2
14	Nucleotide Excision Repair⁵³ Hide members DNA Repair⁵³	10.5	MUTYH, LIG4, BRCA2, BRCA1
15	Integrated Pancreatic Cancer Pathway³⁷	10.5	BRCA1, BRCA2, APC, CDKN2B
16	Pathways in cancer²⁹	10.5	BRCA2, BRAF, APC, E2F2, MLH1, CDKN2B
17	Chronic myeloid leukemia²⁹ Hide members Pancreatic cancer²⁹	10.5	E2F2, BRAF, BRCA2
18	Homologous recombination³⁷ Hide members Homologous recombination²⁹	10.5	BRCA2, XRCC3, XRCC2
19	Glioma²⁹ Hide members Signaling Pathways in Glioblastoma³⁷ Melanoma²⁹ Non-small cell lung cancer²⁹ Bladder cancer²⁹ Prostate cancer²⁹	10.5	BRCA1, BRCA2, BRAF, E2F2, CDKN2B, MSH6
20	Glioblastoma Multiforme⁵¹	10.5	BRAF, APC, E2F2
21	GPCR Pathway⁵¹ Hide members Pancreatic Adenocarcinoma⁵¹ Breast Cancer Regulation by Stathmin1⁵¹ P2Y Receptor Signaling⁵¹ Ras Pathway⁵¹ Estrogen Pathway⁵¹	10.5	CDKN2B, E2F2, BRAF, BRCA2, BRCA1

Compounds for genes affiliated with Lynch Syndrome

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ⁵⁹Tocris Bioscience, ¹¹DrugBank, ²⁴HMDB, ²⁸IUPHAR
See all sources

Compounds related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 41)

id	Compound	Score	Top Affiliating Genes
1	crcs⁴⁴	10.9	PMS2, BRAF, APC, MLH1, MSH6, MSH2
2	paraffin⁴⁴	10.9	PMS2, BRCA1, BRCA2, BRAF, APC, MLH1
3	o6-methylguanine⁴⁴	10.9	MSH2, BRCA2, BRAF, APC, MLH1, CDKN2B
4	mononucleotide⁴⁴	10.9	APC, MLH1, MSH6, MSH2
5	cisplatin⁴⁴ ⁴⁹ ⁵⁹ ¹¹	13.9	BRCA1, BRCA2, BRAF, XRCC3, XRCC2, MLH1
6	mhs-2⁴⁴	10.9	PMS1, PMS2, MLH1
7	p003⁴⁴	10.9	BRCA1, BRCA2, XRCC3, MLH1, CDKN2B, EPCAM
8	adenine⁴⁴ ¹¹ ²⁴	12.9	BRCA1, BRAF, APC, MLH1, MUTYH, RNASE1
9	sodium bisulfite⁴⁴	10.9	BRCA1, APC, MLH1, CDKN2B
10	n-methyl-n-nitrosourea⁴⁴	10.9	MLH1, MSH6, MSH2
11	5-methylcytosine⁴⁴ ²⁴	11.9	BRCA1, APC, MLH1, CDKN2B
12	8-oxoguanine⁴⁴	10.9	BRCA1, BRCA2, APC, MUTYH
13	camptothecin⁴⁴ ⁵⁹ ¹¹	12.9	MLH1, XRCC2, XRCC3, BRCA2, BRCA1
14	folate⁴⁴	10.9	BRCA1, BRCA2, XRCC3, APC, MLH1
15	5-aza-2deoxycytidine⁴⁴	10.9	PMS1, BRCA1, APC, MLH1, CDKN2B
16	mnng⁴⁴	10.8	APC, MLH1, MSH2
17	polyacrylamide⁴⁴	10.8	RNASE1, MLH1, APC, BRCA2, BRCA1
18	biotin⁴⁴ ¹¹ ²⁴	12.8	MSH2, MSH6, MLH1, PMS2
19	mitomycin c⁴⁴	10.8	XRCC2, XRCC3, BRCA2, BRCA1
20	af/ap⁴⁴	10.8	APC, MUTYH
21	p002⁴⁴	10.8	BRCA1, BRCA2, BRAF, MLH1
22	oligonucleotide⁴⁴	10.8	BRCA1, BRCA2, BRAF, APC, E2F2, RNASE1
23	gold⁴⁴	10.8	RNASE1, BRCA2
24	methylmethanesulfonate⁴⁴	10.8	APC, BRCA2, BRCA1
25	proline⁴⁴	10.8	BRCA1, BRCA2, MLH1, RNASE1, MSH2
26	oligoribonucleotide⁴⁴	10.8	RNASE1, RNASEL
27	5fluorouracil⁴⁴	10.8	BRCA1, MLH1, EPCAM, MSH2
28	threonine⁴⁴	10.8	BRAF, APC, MLH1, CDKN2B, RNASE1, MSH6
29	alanine⁴⁴	10.8	BRCA1, BRAF, MLH1, LIG4, RNASE1, MSH2
30	carboplatin⁴⁴ ⁴⁹ ¹¹	12.7	MSH2, MLH1, BRCA1
31	oxygen⁴⁴ ²⁴	11.7	BRCA1, RNASE1, RNASEL
32	retinoic acid⁴⁴ ²⁴	11.7	BRCA1, BRCA2, BRAF, APC, MLH1, CDKN2B
33	atp⁴⁴ ²⁸	11.7	BRCA1, BRAF, MLH1, RNASE1, RNASEL, MSH2
34	methionine⁴⁴	10.7	MLH1, APC, XRCC3, BRCA1
35	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	14.6	BRCA1, BRCA2, BRAF, APC, MLH1
36	h2o2⁴⁴	10.6	BRCA1, BRCA2, MLH1, MUTYH, RNASE1
37	paclitaxel⁴⁴ ⁴⁹ ¹¹	12.5	MLH1, BRAF, BRCA2, BRCA1
38	doxorubicin⁴⁴ ⁴⁹ ¹¹	12.5	MSH2, MSH6, MLH1, BRCA1
39	cytosine⁴⁴ ²⁴	11.5	BRCA1, APC, MLH1
40	serine⁴⁴	10.4	BRCA1, BRAF, APC, CDKN2B, RNASE1, MSH6
41	thymidylate⁴⁴	10.2	BRCA1, MLH1, MSH2

GO Terms for genes affiliated with Lynch Syndrome

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Lynch Syndrome according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mismatch repair complex	GO:032300	10.7	MLH3, MLH1, PMS2, PMS1
2	MutLalpha complex	GO:032389	10.6	PMS1, PMS2, MLH1
3	MutLbeta complex	GO:032390	10.6	MLH1, MLH3
4	MutSalpha complex	GO:032301	10.6	MSH6, MSH2
5	chiasma	GO:005712	10.5	MLH1, MLH3
6	synaptonemal complex	GO:000795	10.5	MLH3, MLH1
7	nucleus	GO:005634	10.4	PMS1, PMS2, BRCA1, BRCA2, BRAF, XRCC3
8	male germ cell nucleus	GO:001673	10.2	MLH3, MLH1

Biological processes related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	mismatch repair	GO:006298	10.9	MSH2, MSH6, MUTYH, MLH3, MLH1, PMS2
2	reciprocal meiotic recombination	GO:007131	10.8	MLH3, MLH1, PMS2, PMS1, MSH6
3	somatic hypermutation of immunoglobulin genes	GO:016446	10.8	PMS2, MSH2, MSH6, MLH1
4	DNA repair	GO:006281	10.8	BRCA1, BRCA2, XRCC3, XRCC2, LIG4, MUTYH
5	isotype switching	GO:045190	10.8	LIG4, MLH1, MSH6, MSH2
6	ATP catabolic process	GO:006200	10.8	PMS1, MLH3, PMS2, MLH1, MSH6
7	response to X-ray	GO:010165	10.8	LIG4, BRCA2, XRCC2, MSH2
8	somatic recombination of immunoglobulin gene segments	GO:016447	10.8	MSH6, PMS2, MSH2
9	double-strand break repair	GO:006302	10.8	BRCA2, LIG4, MSH2, BRCA1
10	intrinsic apoptotic signaling pathway in response to DNA damage	GO:008630	10.8	MSH6, BRCA1, MLH1
11	meiotic mismatch repair	GO:000710	10.7	MSH2, MSH6
12	response to gamma radiation	GO:010332	10.7	BRCA2, XRCC2, LIG4
13	double-strand break repair via homologous recombination	GO:000724	10.7	XRCC2, BRCA2, BRCA1
14	positive regulation of helicase activity	GO:051096	10.7	MSH2, MSH6
15	maintenance of DNA repeat elements	GO:043570	10.7	MSH6, MSH2
16	negative regulation of DNA recombination	GO:045910	10.7	MSH6, MSH2
17	postreplication repair	GO:006301	10.6	MSH2, BRCA1
18	positive regulation of epithelial cell differentiation	GO:030858	10.6	APC, CDKN2B
19	determination of adult lifespan	GO:008340	10.6	MSH6, MSH2
20	negative regulation of neuron apoptotic process	GO:043524	10.5	XRCC2, LIG4, MSH2
21	chromosome organization	GO:051276	10.5	LIG4, APC
22	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	10.4	BRCA1, BRCA2
23	double-strand break repair via nonhomologous end joining	GO:006303	10.2	MLH1, LIG4

Molecular functions related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	MutSalpha complex binding	GO:032407	10.8	MUTYH, MLH3, MLH1, PMS2, PMS1
2	single-stranded DNA binding	GO:003697	10.8	PMS1, PMS2, BRCA2, MLH1, MLH3, MSH2
3	ATPase activity	GO:016887	10.8	PMS1, PMS2, MLH1, MLH3, MSH6, MSH2
4	mismatched DNA binding	GO:030983	10.7	PMS1, MLH3, MSH6, MSH2
5	protein binding	GO:005515	10.7	E2F2, APC, XRCC2, XRCC3, BRAF, BRCA2
6	ATP binding	GO:005524	10.7	PMS1, PMS2, BRAF, XRCC3, XRCC2, MLH1
7	guanine/thymine mispair binding	GO:032137	10.7	MLH1, MSH6, MSH2
8	DNA-dependent ATPase activity	GO:008094	10.6	XRCC3, XRCC2, MSH6, MSH2
9	MutLalpha complex binding	GO:032405	10.6	MSH2, MSH6, MUTYH
10	single thymine insertion binding	GO:032143	10.6	MSH6, MSH2
11	single guanine insertion binding	GO:032142	10.6	MSH2, MSH6
12	oxidized purine DNA binding	GO:032357	10.5	MSH2, MSH6
13	centromeric DNA binding	GO:019237	10.5	MSH2, MLH3
14	four-way junction DNA binding	GO:000400	10.4	MSH6, MSH2
15	DNA binding	GO:003677	10.2	PMS1, PMS2, BRCA1, XRCC3, XRCC2, E2F2