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COCA1
MCID: LYN001
MIFTS: 63

Lynch Syndrome (COCA1) malady
107 genes, 139 related diseases, clinical trials, genetic tests.

Summaries for Lynch Syndrome

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43NIH Rare Diseases, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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Genetics Home Reference:21 Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, and skin. Additionally, women with this disorder have a high risk of cancer of the ovaries and lining of the uterus (the endometrium). People with Lynch syndrome may occasionally have noncancerous (benign) growths (polyps) in the colon, called colon polyps. In individuals with this disorder, colon polyps occur earlier but not in greater numbers than they do in the general population.

MalaCards: Lynch Syndrome, also known as hereditary nonpolyposis colorectal cancer, is related to colorectal cancer and adenoma. An important gene associated with Lynch Syndrome is PMS1 (PMS1 postmeiotic segregation increased 1 (S. cerevisiae)), and among its related pathways are Lagging Strand Synthesis and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds crcs and paraffin have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and cellular.

NIH Rare Diseases:43 Lynch syndrome is an inherited condition that causes an increased risk of developing cancer. individuals with lynch syndrome have a higher risk of developing colon and rectal cancer, as well as cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, skin, and prostate. women with lynch syndrome also have a high risk of developing uterine cancer (also called endometrial cancer) and ovarian cancer. even though the disorder was originally described as not involving noncancerous (benign) growths (polyps) in the colon, people with lynch syndrome may occasionally have colon polyps. lynch syndrome has an autosomal dominant pattern of inheritance and is caused by a mutation in the mlh1, msh2, msh6, pms2 or epcam gene. last updated: 10/18/2013

Wikipedia:64 Lynch syndrome (HNPCC or hereditary nonpolyposis colorectal cancer ) is an autosomal dominant genetic... more...

Description from OMIM:47 613244,120435,609310

GeneReviews summary for hnpcc

Aliases & Classifications for Lynch Syndrome

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8Disease Ontology, 64Wikipedia, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 61UMLS, 47OMIM, 57SNOMED-CT, 35MeSH
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Aliases & Descriptions:

lynch syndrome 8 64 19 43 20 22 21 10 45
hereditary nonpolyposis colorectal cancer 8 64 43 21 61
familial nonpolyposis colon cancer 64 43 21
hnpcc 64 19 21
colon cancer, familial nonpolyposis 64 43
cancer family syndrome 64 21
colorectal cancer, hereditary nonpolyposis, type 1 61
hereditary defective mismatch repair syndrome 8
hereditary non-polyposis colon cancer type 1 8
hnpcc - hereditary nonpolyposis colon cancer 8
hereditary nonpolyposis colorectal neoplasms 21
hereditary nonpolyposis colorectal neoplasm 8
colorectal cancer, hereditary nonpolyposis 43
hereditary non-polyposis colon cancer 19
hereditary nonpolyposis colon cancer 45
lynch cancer family syndrome 2 61
coca 1 8
coca1 43


External Ids:

Disease Ontology8 DOID:3883
SNOMED-CT57 315058005
MeSH35 D003123

Related Diseases for Lynch Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Lynch Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.5PMS1, PMS2, BRAF, APC, MLH1, MUTYH
2adenoma30.9PMS2, BRCA1, BRAF, XRCC3, APC, MLH1
3familial colorectal cancer30.8BRCA1, BRCA2, APC, MLH1, MSH6, MSH2
4adenocarcinoma30.6PMS2, BRCA1, BRCA2, BRAF, XRCC3, APC
5familial adenomatous polyposis30.6PMS1, PMS2, BRCA1, BRAF, APC, MLH1
6male breast cancer30.5BRCA2, BRCA1
7gastric cancer, somatic30.4APC, MUTYH
8muir-torre syndrome30.4C3orf35, MSH2, MSH6, MLH1
9turcot syndrome30.2PMS2, MLH1
10transitional cell carcinoma30.2MSH2, CDKN2B, MLH1
11neurofibromatosis30.1MSH2, MSH6, MLH1, BRCA2, PMS2
12thyroid cancer30.0APC, BRAF
13brain cancer30.0APC, CDKN2B, MSH6, MSH2
14colorectal cancer, somatic30.0MLH3, APC
15n syndrome10.9
16micro syndrome10.6
17char syndrome10.5
18colorectal cancer, hereditary nonpolyposis, type 810.5
19colorectal cancer, hereditary nonpolyposis, type 510.5
20colorectal cancer, hereditary nonpolyposis, type 610.5
21colorectal cancer, hereditary nonpolyposis, type 210.5
22colorectal cancer, hereditary nonpolyposis, type 410.5
23colorectal cancer, hereditary nonpolyposis, type 710.5
24small bowel adenocarcinoma10.5
25young syndrome10.4
26non-hodgkin lymphoma10.3
27hereditary hemorrhagic telangiectasia10.3
28uterine carcinosarcoma10.3
29attenuated familial adenomatous polyposis10.3
30follicular lymphoma10.3
31ciliary dyskinesia, primary, 2710.3
32colorectal cancer 1210.3
33colorectal cancer 1010.3
34hyperplastic polyposis syndrome10.3
35desmoid tumor10.3
36fibromatosis10.3
37colorectal cancer, hereditary nonpolyposis, type 110.3
38colorectal cancer 110.2
39hereditary breast ovarian cancer10.1
40protein s deficiency10.1
41protein c deficiency10.1
423-m syndrome10.1
43german syndrome10.1
44kid syndrome10.1
45protein r deficiency10.1
46star syndrome10.1
47mlh1-related lynch syndrome10.1
48msh2-related lynch syndrome10.1
49msh6-related lynch syndrome10.1
50pms2-related lynch syndrome10.1

Graphical network of the top 20 diseases related to Lynch Syndrome:



Diseases related to lynch syndrome

Clinical Features for Lynch Syndrome

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47OMIM
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Clinical features from OMIM:

613244,120435,609310

Drugs & Therapeutics for Lynch Syndrome

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Lynch Syndrome

Drug clinical trials:

Search ClinicalTrials for Lynch Syndrome

Search NIH Clinical Center for Lynch Syndrome

Search CenterWatch for Lynch Syndrome

Genetic Tests for Lynch Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Lynch Syndrome:

id Genetic test Affiliating Genes
1 Lynch Syndrome20 22

Anatomical Context for Lynch Syndrome

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Animal Models for Lynch Syndrome or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Lynch Syndrome:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
tumorigenesis
MP:000200610.7MSH2, PMS1, PMS2, BRAF, MLH1, CDKN2B
2
cellular phenotype
MP:000538410.7APC, XRCC2, BRAF, BRCA2, BRCA1, PMS2
3
mortality/aging
MP:001076810.7APC, XRCC2, BRAF, BRCA2, BRCA1, PMS2
4
integument phenotype
MP:001077110.6BRCA1, BRCA2, XRCC2, APC, E2F2, CDKN2B
5
homeostasis/metabolism phenotype
MP:000537610.6PMS2, BRCA1, BRCA2, XRCC2, LIG4, MUTYH
6
digestive/alimentary phenotype
MP:000538110.6PMS2, BRCA1, BRCA2, BRAF, APC, MLH1
7
hematopoietic system phenotype
MP:000539710.5PMS2, BRCA1, BRCA2, BRAF, APC, E2F2
8
endocrine/exocrine gland phenotype
MP:000537910.5PMS2, BRCA1, BRCA2, MLH1, MLH3, CDKN2B
9
nervous system phenotype
MP:000363110.5EPCAM, MUTYH, LIG4, APC
10
immune system phenotype
MP:000538710.4PMS2, BRCA1, BRCA2, BRAF, APC, E2F2
11
reproductive system phenotype
MP:000538910.2BRCA1, BRCA2, BRAF, APC, MLH1, MLH3

Publications for Lynch Syndrome

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51PubMed
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Articles related to Lynch Syndrome:

(show top 50)    (show all 566)
idTitleAuthorsYear
1
Balancing Life with an Increased Risk of Cancer: Lived Experiences in Healthy Individuals with Lynch Syndrome. (24399096)
2014
2
Lynch syndrome: a pediatric perspective. (24051481)
2014
3
Correction: Dietary Supplement Use and Colorectal Adenoma Risk in Individuals with Lynch Syndrome: The GEOLynch Cohort Study. (24392052)
2014
4
The role of epigenetics in Lynch syndrome. (23462881)
2013
5
Comparison of the clinical prediction model PREMM(1,2,6) and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer. (22345660)
2013
6
Combined analysis of three Lynch syndrome cohorts confirms the modifying effects of 8q23.3 and 11q23.1 in MLH1 mutation carriers. (22987364)
2013
7
Cell cycle-related genes as modifiers of age of onset of colorectal cancer in Lynch syndrome: a large-scale study in non-Hispanic white patients. (23125224)
2013
8
Ovarian carcinoma in situ of presumable fallopian tube origin in a patient with Lynch syndrome: A case report. (24371700)
2013
9
Unique endoscopic findings of colitis-associated colorectal cancer in a patient with ulcerative colitis and Lynch syndrome. (24295648)
2013
10
No evidence of genetic anticipation in a large family with Lynch syndrome. (23771324)
2013
11
The Lynch syndrome: a management dilemma. (23645768)
2013
12
Prevalence of occult gynecologic malignancy at the time of risk reducing and nonprophylactic surgery in patients with Lynch syndrome. (24211399)
2013
13
Mismatch repair gene mutation analysis and colonoscopy surveillance in Chinese lynch syndrome families. (23640085)
2013
14
Lynch syndrome: history, causes, diagnosis, treatment and prevention (CAPP2 trial). (23207931)
2012
15
Causes of death of mutation carriers in Finnish Lynch syndrome families. (22684865)
2012
16
Comparison between universal molecular screening for Lynch syndrome and revised Bethesda guidelines in a large population-based cohort of patients with colorectal cancer. (21868491)
2012
17
Lynch syndrome: new tales from the crypt. (22552010)
2012
18
A novel germline MLH1 mutation causing Lynch Syndrome in patients from the Republic of Macedonia. (23100212)
2012
19
Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome. (22933731)
2012
20
Diagnosing Lynch syndrome: more light at the end of the tunnel. (22491516)
2012
21
Prospective study of combined colon and endometrial cancer screening in women with lynch syndrome: a patient-centered approach. (21532810)
2011
22
Preoperative diagnosis of Lynch syndrome with DNA mismatch repair immunohistochemistry on a diagnostic biopsy. (22067175)
2011
23
The role of expanded testing for Lynch syndrome in women with endometrial cancer. (21826641)
2011
24
Non-truncating hMLH1 variants identified in Slovenian gastric cancer patients are not associated with Lynch Syndrome: a functional analysis report. (21136174)
2011
25
A systematic review of gynecological cancer surveillance in women belonging to hereditary nonpolyposis colorectal cancer (Lynch syndrome) families. (21306348)
2011
26
Lynch syndrome. (21748965)
2011
27
Lynch syndrome-associated extracolonic tumors are rare in two extended families with the same EPCAM deletion. (21769135)
2011
28
EPCAM deletions, Lynch syndrome, and cancer risk. (21195320)
2011
29
Association of low-risk MSH3 and MSH2 variant alleles with Lynch syndrome: probability of synergistic effects. (21128252)
2011
30
Development and validation of an instrument to measure the impact of genetic testing on self-concept in Lynch syndrome. (21883167)
2011
31
On the advent of MSI testing of all colorectal cancers and a substantial part of other Lynch syndrome-related neoplasms. (20465492)
2010
32
Clinical utility gene card for: Lynch syndrome (MLH1, MSH2, MSH6, PMS2). (20104243)
2010
33
Risk assessment, genetic testing, and management of Lynch syndrome. (20064292)
2010
34
Colorectal cancer survival advantage in MUTYH-associated polyposis and Lynch syndrome families. (21044965)
2010
35
Epitope-positive truncating MLH1 mutation and loss of PMS2: implications for IHC-directed genetic testing for Lynch syndrome. (19672700)
2009
36
In Lynch syndrome adenomas, loss of mismatch repair proteins is related to an enhanced lymphocytic response. (19817892)
2009
37
An interstitial deletion at 3p21.3 results in the genetic fusion of MLH1 and ITGA9 in a Lynch syndrome family. (19188145)
2009
38
Endometrial cancer and Lynch syndrome: clinical and pathologic considerations. (19078925)
2009
39
Improvement of endometrial biopsy over transvaginal ultrasound alone for endometrial surveillance in women with Lynch syndrome. (19504173)
2009
40
Strategies for endometrial screening in the Lynch syndrome population: a patient acceptability study. (19526324)
2009
41
Chromosome 8q23.3 and 11q23.1 variants modify colorectal cancer risk in Lynch syndrome. (19010329)
2009
42
Comprehensive molecular analysis of mismatch repair gene defects in suspected Lynch syndrome (hereditary nonpolyposis colorectal cancer) cases. (19690142)
2009
43
Current and emerging trends in Lynch syndrome identification in women with endometrial cancer. (19375789)
2009
44
The G67E mutation in hMLH1 is associated with an unusual presentation of Lynch syndrome. (19142183)
2009
45
Prediction of Lynch syndrome in consecutive patients with colorectal cancer. (19244167)
2009
46
The frequency of Muir-Torre syndrome among Lynch syndrome families. (18270343)
2008
47
Novel approaches in evaluation of pathogenicity of single-base exonic germline changes involving the mismatch repair genes MLH1 and MSH2 in diagnostics of Lynch syndrome. (18999873)
2008
48
Prospective results of surveillance colonoscopy in dominant familial colorectal cancer with and without Lynch syndrome. (16762622)
2006
49
Prediction of MLH1 and MSH2 mutations in Lynch syndrome. (17003395)
2006
50
Three new mutations in hereditary nonpolyposis colorectal cancer (Lynch syndrome II) in Uruguay. (12660027)
2003

Genetic Variations for Lynch Syndrome

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Expression for genes affiliated with Lynch Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lynch Syndrome

Search GEO for disease gene expression data for Lynch Syndrome.

Pathways for genes affiliated with Lynch Syndrome

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54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 30KEGG, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Lagging Strand Synthesis54
Hide members
10.5MLH1, PMS1, PMS2, MLH3, MSH6, MSH2
2
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.5MLH1, BRCA1, BRCA2, MSH6, MSH2
3
DNA Damage4
Hide members
10.5MSH6, BRCA1, BRCA2, MSH2, MLH1, MUTYH
4
Fanconi anemia pathway30
10.5BRCA1, BRCA2, MLH1, PMS2
5
Direct p53 effectors38
10.5APC, PMS2, MLH1, MSH2
6
Prostate Cancer38
Hide members
10.5BRCA1, MSH6, MSH2
7
Meiotic Synapsis54
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10.5MLH3, MLH1, BRCA2, BRCA1
8
Endometrial cancer30
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10.5BRAF, APC, MLH1, MSH6, MSH2
9
Integrated Breast Cancer Pathway38
10.5BRCA1, BRAF, BRCA2, MSH2, MSH6, XRCC3
10
BRCA1 Pathway52
10.5BRCA2, E2F2, BRCA1, MSH2, MSH6
11
Homologous Recombination Repair54
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10.5BRCA2, BRCA1, LIG4
12
Colorectal Cancer Metastasis52
10.5MSH6, APC, BRAF
13
Chks in Checkpoint Regulation52
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10.5LIG4, E2F2, BRCA2, BRCA1, MSH6, MSH2
14
Nucleotide Excision Repair54
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10.5BRCA2, BRCA1, MUTYH, LIG4
15
Integrated Pancreatic Cancer Pathway38
10.5APC, BRCA2, CDKN2B, BRCA1
16
Pathways in cancer30
10.5MLH1, CDKN2B, E2F2, BRCA2, MSH6, MSH2
17
Chronic myeloid leukemia30
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10.5BRCA2, E2F2, BRAF
18
Homologous recombination38
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10.5XRCC2, BRCA2, XRCC3
19
Glioma30
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10.5MSH6, BRCA2, BRAF, E2F2, CDKN2B, BRCA1
20
Glioblastoma Multiforme52
10.5BRAF, APC, E2F2
21
GPCR Pathway52
Hide members
10.5CDKN2B, BRCA1, BRCA2, BRAF, E2F2

Compounds for genes affiliated with Lynch Syndrome

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45Novoseek, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 29IUPHAR
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Compounds related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1crcs4510.9PMS2, BRAF, APC, MLH1, MSH6, MSH2
2paraffin4510.9PMS2, BRCA1, BRCA2, BRAF, APC, MLH1
3o6-methylguanine4510.9MSH2, BRCA2, BRAF, APC, MLH1, CDKN2B
4mononucleotide4510.9APC, MLH1, MSH6, MSH2
5cisplatin45 50 60 1113.9BRCA1, BRCA2, BRAF, XRCC3, XRCC2, MLH1
6mhs-24510.9PMS1, PMS2, MLH1
7p0034510.9BRCA1, BRCA2, XRCC3, MLH1, CDKN2B, EPCAM
8adenine45 11 2412.9BRCA1, BRAF, APC, MLH1, MUTYH, RNASE1
9sodium bisulfite4510.9BRCA1, APC, MLH1, CDKN2B
10n-methyl-n-nitrosourea4510.9MLH1, MSH6, MSH2
115-methylcytosine45 2411.9BRCA1, APC, MLH1, CDKN2B
128-oxoguanine4510.9BRCA1, BRCA2, APC, MUTYH
13camptothecin45 60 1112.9MLH1, XRCC2, XRCC3, BRCA2, BRCA1
14folate4510.9BRCA1, BRCA2, XRCC3, APC, MLH1
155-aza-2deoxycytidine4510.9PMS1, BRCA1, APC, MLH1, CDKN2B
16mnng4510.8APC, MLH1, MSH2
17polyacrylamide4510.8RNASE1, MLH1, APC, BRCA2, BRCA1
18biotin45 11 2412.8MSH2, MSH6, MLH1, PMS2
19mitomycin c4510.8XRCC2, XRCC3, BRCA2, BRCA1
20af/ap4510.8APC, MUTYH
21p0024510.8BRCA1, BRCA2, BRAF, MLH1
22oligonucleotide4510.8BRCA1, BRCA2, BRAF, APC, E2F2, RNASE1
23gold4510.8RNASE1, BRCA2
24methylmethanesulfonate4510.8APC, BRCA2, BRCA1
25proline4510.8BRCA1, BRCA2, MLH1, RNASE1, MSH2
26oligoribonucleotide4510.8RNASE1, RNASEL
275fluorouracil4510.8BRCA1, MLH1, EPCAM, MSH2
28threonine4510.8BRAF, APC, MLH1, CDKN2B, RNASE1, MSH6
29alanine4510.8BRCA1, BRAF, MLH1, LIG4, RNASE1, MSH2
30carboplatin45 50 1112.7MSH2, MLH1, BRCA1
31oxygen45 2411.7BRCA1, RNASE1, RNASEL
32retinoic acid45 2411.7BRCA1, BRCA2, BRAF, APC, MLH1, CDKN2B
33atp45 2911.7BRCA1, BRAF, MLH1, RNASE1, RNASEL, MSH2
34methionine4510.7MLH1, APC, XRCC3, BRCA1
35progesterone45 60 29 11 2414.6BRCA1, BRCA2, BRAF, APC, MLH1
36h2o24510.6BRCA1, BRCA2, MLH1, MUTYH, RNASE1
37paclitaxel45 50 1112.5MLH1, BRAF, BRCA2, BRCA1
38doxorubicin45 50 1112.5MSH2, MSH6, MLH1, BRCA1
39cytosine45 2411.5BRCA1, APC, MLH1
40serine4510.4BRCA1, BRAF, APC, CDKN2B, RNASE1, MSH6
41thymidylate4510.2BRCA1, MLH1, MSH2

GO Terms for genes affiliated with Lynch Syndrome

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16Gene Ontology
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Cellular components related to Lynch Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repair complexGO:03230010.7MLH3, MLH1, PMS2, PMS1
2MutLalpha complexGO:03238910.6PMS1, PMS2, MLH1
3MutLbeta complexGO:03239010.6MLH1, MLH3
4MutSalpha complexGO:03230110.6MSH6, MSH2
5chiasmaGO:00571210.5MLH1, MLH3
6synaptonemal complexGO:00079510.5MLH3, MLH1
7nucleusGO:00563410.4PMS1, PMS2, BRCA1, BRCA2, BRAF, XRCC3
8male germ cell nucleusGO:00167310.2MLH3, MLH1

Biological processes related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629810.9MSH2, PMS1, PMS2, MLH1, MLH3, MUTYH
2reciprocal meiotic recombinationGO:00713110.8PMS1, PMS2, MLH1, MLH3, MSH6
3somatic hypermutation of immunoglobulin genesGO:01644610.8MSH2, MSH6, MLH1, PMS2
4DNA repairGO:00628110.8BRCA1, BRCA2, XRCC3, XRCC2, LIG4, MUTYH
5isotype switchingGO:04519010.8MLH1, LIG4, MSH6, MSH2
6ATP catabolic processGO:00620010.8MSH6, MLH3, MLH1, PMS2, PMS1
7response to X-rayGO:01016510.8BRCA2, XRCC2, LIG4, MSH2
8somatic recombination of immunoglobulin gene segmentsGO:01644710.8PMS2, MSH6, MSH2
9double-strand break repairGO:00630210.8MSH2, LIG4, BRCA2, BRCA1
10intrinsic apoptotic signaling pathway in response to DNA damageGO:00863010.8MSH6, MLH1, BRCA1
11meiotic mismatch repairGO:00071010.7MSH2, MSH6
12response to gamma radiationGO:01033210.7BRCA2, XRCC2, LIG4
13double-strand break repair via homologous recombinationGO:00072410.7XRCC2, BRCA2, BRCA1
14positive regulation of helicase activityGO:05109610.7MSH6, MSH2
15maintenance of DNA repeat elementsGO:04357010.7MSH6, MSH2
16postreplication repairGO:00630110.7MSH2, BRCA1
17positive regulation of epithelial cell differentiationGO:03085810.6CDKN2B, APC
18negative regulation of DNA recombinationGO:04591010.6MSH2, MSH6
19determination of adult lifespanGO:00834010.6MSH6, MSH2
20negative regulation of neuron apoptotic processGO:04352410.5MSH2, LIG4, XRCC2
21chromosome organizationGO:05127610.5LIG4, APC
22DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.4BRCA1, BRCA2
23double-strand break repair via nonhomologous end joiningGO:00630310.2LIG4, MLH1

Molecular functions related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1MutSalpha complex bindingGO:03240710.8MUTYH, MLH3, MLH1, PMS2, PMS1
2single-stranded DNA bindingGO:00369710.8PMS1, PMS2, BRCA2, MLH1, MLH3, MSH2
3ATPase activityGO:01688710.8PMS1, PMS2, MLH1, MLH3, MSH6, MSH2
4mismatched DNA bindingGO:03098310.7PMS1, MLH3, MSH6, MSH2
5protein bindingGO:00551510.7E2F2, APC, XRCC2, XRCC3, BRAF, BRCA2
6ATP bindingGO:00552410.7PMS1, PMS2, BRAF, XRCC3, XRCC2, MLH1
7guanine/thymine mispair bindingGO:03213710.7MLH1, MSH6, MSH2
8DNA-dependent ATPase activityGO:00809410.6XRCC3, XRCC2, MSH6, MSH2
9MutLalpha complex bindingGO:03240510.6MSH2, MSH6, MUTYH
10single thymine insertion bindingGO:03214310.6MSH6, MSH2
11single guanine insertion bindingGO:03214210.6MSH2, MSH6
12oxidized purine DNA bindingGO:03235710.5MSH2, MSH6
13centromeric DNA bindingGO:01923710.5MSH2, MLH3
14four-way junction DNA bindingGO:00040010.4MSH6, MSH2
15DNA bindingGO:00367710.2PMS1, PMS2, BRCA1, XRCC3, XRCC2, E2F2

Products for genes affiliated with Lynch Syndrome

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Sources for Lynch Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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