COCA1
MCID: LYN001
MIFTS: 70

Lynch Syndrome (COCA1) malady

Gastrointestinal diseases, Cancer diseases, Genetic diseases categories

Summaries for Lynch Syndrome

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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Genetics Home Reference:21 Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, and skin. Additionally, women with this disorder have a high risk of cancer of the ovaries and lining of the uterus (the endometrium). People with Lynch syndrome may occasionally have noncancerous (benign) growths (polyps) in the colon, called colon polyps. In individuals with this disorder, colon polyps occur earlier but not in greater numbers than they do in the general population.

MalaCards: Lynch Syndrome, also known as hereditary nonpolyposis colorectal cancer, is related to colorectal cancer and adenoma. An important gene associated with Lynch Syndrome is PMS1 (PMS1 postmeiotic segregation increased 1 (S. cerevisiae)), and among its related pathways are Lagging Strand Synthesis and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds crcs and paraffin have been mentioned in the context of this disorder. Affiliated tissues include colon, brain and skin, and related mouse phenotypes are tumorigenesis and cellular.

NIH Rare Diseases:42 Lynch syndrome is an inherited condition that causes an increased risk of developing cancer. individuals with lynch syndrome have a higher risk of developing colon and rectal cancer, as well as cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, skin, and prostate. women with lynch syndrome also have a high risk of developing uterine cancer (also called endometrial cancer) and ovarian cancer. even though the disorder was originally described as not involving noncancerous (benign) growths (polyps) in the colon, people with lynch syndrome may occasionally have colon polyps. lynch syndrome has an autosomal dominant pattern of inheritance and is caused by a mutation in the mlh1, msh2, msh6, pms2 or epcam gene. last updated: 10/18/2013

Wikipedia:63 Lynch syndrome (HNPCC or hereditary nonpolyposis colorectal cancer ) is an autosomal dominant genetic... more...

Description from OMIM:46 613244,120435,609310

GeneReviews summary for hnpcc

Aliases & Classifications for Lynch Syndrome

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8Disease Ontology, 63Wikipedia, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

lynch syndrome 8 63 19 42 20 22 21 10 44
hereditary nonpolyposis colorectal cancer 8 63 42 21 60
familial nonpolyposis colon cancer 63 42 21
hnpcc 63 19 21
colon cancer, familial nonpolyposis 63 42
cancer family syndrome 63 21
colorectal cancer, hereditary nonpolyposis, type 1 60
hereditary defective mismatch repair syndrome 8
hereditary non-polyposis colon cancer type 1 8
hnpcc - hereditary nonpolyposis colon cancer 8
hereditary nonpolyposis colorectal neoplasms 21
hereditary nonpolyposis colorectal neoplasm 8
colorectal cancer, hereditary nonpolyposis 42
hereditary non-polyposis colon cancer 19
hereditary nonpolyposis colon cancer 44
lynch cancer family syndrome 2 60
coca 1 8
coca1 42


External Ids:

Disease Ontology8 DOID:3883
SNOMED-CT56 315058005
MeSH34 D003123

Related Diseases for Lynch Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Lynch Syndrome family:

Mlh1-Related Lynch Syndrome Msh2-Related Lynch Syndrome
Msh6-Related Lynch Syndrome Pms2-Related Lynch Syndrome
Epcam-Related Lynch Syndrome Mlh3-Related Lynch Syndrome
Pms1-Related Lynch Syndrome

Diseases related to Lynch Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.5PMS1, PMS2, BRAF, APC, MLH1, MUTYH
2adenoma30.8APC, BRAF, BRCA1, MLH1, MUTYH, MSH6
3colon cancer30.7APC, BRAF, MSH2, EPCAM, MLH1, MSH6
4breast cancer30.6MSH2, EPCAM, MSH6, BRCA1, BRCA2
5adenocarcinoma30.6PMS2, MSH2, BRCA1, EPCAM, BRAF, XRCC3
6familial adenomatous polyposis30.6PMS2, PMS1, MSH2, BRCA1, MSH6, MUTYH
7ovarian cancer30.6MSH2, EPCAM, MLH1, BRAF, BRCA2, BRCA1
8prostate cancer30.5PMS1, PMS2, BRCA1, BRCA2, APC, LIG4
9endometrial carcinoma30.5BRCA2, MSH2, MLH1, BRAF, BRCA1, MSH6
10melanoma30.4MSH2, EPCAM, PMS1, PMS2, RNASE1, BRCA2
11retinoblastoma30.4PMS1, BRCA1, APC, CDKN2B, BRCA2, EPCAM
12male breast cancer30.4BRCA2, BRCA1
13gastric cancer, somatic30.4MUTYH, APC
14muir-torre syndrome30.4MSH6, MLH1, C3orf35, MSH2
15pancreatic cancer30.2MSH2, RNASE1, EPCAM, MLH1, BRAF, BRCA2
16pancreatitis30.2BRCA2, RNASE1
17turcot syndrome30.2PMS2, MLH1
18transitional cell carcinoma30.2MLH1, CDKN2B, MSH2
19neurofibromatosis30.1MSH2, MLH1, BRCA2, PMS2, MSH6
20thyroid cancer29.9BRAF, APC
21li-fraumeni syndrome29.9BRCA1, MLH1, BRCA2
22hepatocellular carcinoma29.9APC, EPCAM, CDKN2B, MUTYH, BRCA2
23brca1 and brca2 hereditary breast and ovarian cancer29.9BRCA1, BRCA2
24brain cancer29.9CDKN2B, APC, MSH2, MSH6
25oligodendroglioma29.9BRAF, CDKN2B
26sarcoma29.9MLH1, MSH2, BRCA2, BRAF
27hematologic cancer29.9MSH2, MLH1, CDKN2B, MSH6
28keratoacanthoma29.9MSH2, MLH1
29colorectal cancer, hereditary nonpolyposis, type 810.5
30colorectal cancer, hereditary nonpolyposis, type 510.5
31colorectal cancer, hereditary nonpolyposis, type 610.5
32colorectal cancer, hereditary nonpolyposis, type 210.5
33colorectal cancer, hereditary nonpolyposis, type 410.5
34colorectal cancer, hereditary nonpolyposis, type 710.5
35prostatitis10.4
36non-hodgkin lymphoma10.3
37hereditary hemorrhagic telangiectasia10.3
38lymphoepithelioma-like carcinoma10.3
39uterine carcinosarcoma10.3
40duodenitis10.3
41liposarcoma10.3
42pleomorphic rhabdomyosarcoma10.3
43rhabdomyosarcoma10.3
44ciliary dyskinesia, primary, 2710.3
45colorectal cancer, hereditary nonpolyposis, type 110.3
46hereditary breast ovarian cancer10.1
47endometriosis10.1
48peritonitis10.1
49mlh1-related lynch syndrome10.1
50msh2-related lynch syndrome10.1

Graphical network of the top 20 diseases related to Lynch Syndrome:



Diseases related to lynch syndrome

Clinical Features for Lynch Syndrome

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46OMIM
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Clinical features from OMIM:

613244,120435,609310

Drugs & Therapeutics for Lynch Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lynch Syndrome

Drug clinical trials:

Search ClinicalTrials for Lynch Syndrome

Search NIH Clinical Center for Lynch Syndrome

Search CenterWatch for Lynch Syndrome

Genetic Tests for Lynch Syndrome

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Lynch Syndrome:

id Genetic test Affiliating Genes
1 Lynch Syndrome20 22

Anatomical Context for Lynch Syndrome

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32MalaCards
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MalaCards organs/tissues related to Lynch Syndrome:

32
Colon, Brain, Skin, Small intestine, Testes, Ovary, Liver, Prostate, Uterus, Breast, Kidney, Thyroid, Lung, Pancreas

Animal Models for Lynch Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lynch Syndrome:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.7MSH2, PMS1, PMS2, BRAF, MLH1, CDKN2B
2MP:000538410.7APC, XRCC2, BRAF, BRCA2, BRCA1, PMS2
3MP:001076810.7APC, XRCC2, BRAF, BRCA2, BRCA1, PMS2
4MP:001077110.6BRCA1, BRCA2, XRCC2, APC, E2F2, CDKN2B
5MP:000537610.6PMS2, BRCA1, BRCA2, XRCC2, LIG4, MUTYH
6MP:000538110.6PMS2, BRCA1, BRCA2, BRAF, APC, MLH1
7MP:000539710.5PMS2, BRCA1, BRCA2, BRAF, APC, E2F2
8MP:000537910.5PMS2, BRCA1, BRCA2, MLH1, MLH3, CDKN2B
9MP:000363110.5EPCAM, MUTYH, LIG4, APC
10MP:000538710.4PMS2, BRCA1, BRCA2, BRAF, APC, E2F2
11MP:000538910.2BRCA1, BRCA2, BRAF, APC, MLH1, MLH3

Publications for Lynch Syndrome

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50PubMed
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Articles related to Lynch Syndrome:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Prostate cancer incidence in males with Lynch syndrome. (24434690)
2014
2
Germline mutation and protein expression analysis of mismatch repair genes MSH6 and PMS2 in Malaysian Lynch syndrome patients. (24072394)
2014
3
Value-based healthcare in Lynch syndrome. (23681793)
2013
4
New genetic variants of genes MMR in a Spanish family with Lynch syndrome. (23224667)
2013
5
Chemoprevention in Lynch syndrome. (23880960)
2013
6
Mutation spectrum in South American Lynch syndrome families. (24344984)
2013
7
Changes in screening behaviors and attitudes toward screening from pre-test genetic counseling to post-disclosure in Lynch syndrome families. (23414081)
2013
8
Surveillance for urinary tract cancer in Lynch syndrome. (23700068)
2013
9
Genotype-phenotype correlation in MMR mutation-positive families with Lynch syndrome. (23588873)
2013
10
Immunochemistry screening for Lynch syndrome in colorectal adenocarcinoma using an initial two antibody panel can replace a four antibody panel. (24154771)
2013
11
Psychosocial consequences of predictive genetic testing for Lynch syndrome and associations to surveillance behaviour in a 7-year follow-up study. (23512527)
2013
12
Gene variants of unknown clinical significance in Lynch syndrome. An introduction for clinicians. (23525798)
2013
13
Evaluation of predictive models in daily practice for the identification of patients with Lynch syndrome. (21520036)
2012
14
The molecular basis of EPCAM expression loss in Lynch syndrome-associated tumors. (22388758)
2012
15
Lynch syndrome diagnostics: decision-making process for germ-line testing. (22484632)
2012
16
Endometrioid adenocarcinoma arising from colonic endometriosis in a Lynch syndrome patient. (21698352)
2012
17
Novel germline MLH1 and MSH2 mutations in Latvian Lynch syndrome families. (22453149)
2012
18
Reflex immunohistochemistry and microsatellite instability testing of colorectal tumors for Lynch syndrome among US cancer programs and follow-up of abnormal results. (22355048)
2012
19
A case of endometrial cancer in the context of a BRCA2 mutation and double heterozygosity for Lynch syndrome. (24371622)
2012
20
Screening for Lynch syndrome in colorectal cancer: are we doing enough? (21879275)
2012
21
MLH1 promoter hypermethylation in the analytical algorithm of Lynch syndrome: a cost-effectiveness study. (22274583)
2012
22
Influence of patient preferences on the cost-effectiveness of screening for lynch syndrome. (22942831)
2012
23
Lynch syndrome screening in newly diagnosed colorectal cancer in general pathology practice: from the revised Bethesda guidelines to a universal approach. (21879804)
2011
24
A novel exonic rearrangement affecting MLH1 and the contiguous LRRFIP2 is a founder mutation in Portuguese Lynch syndrome families. (21785361)
2011
25
Recurrence and variability of germline EPCAM deletions in Lynch syndrome. (21309036)
2011
26
Sharing genetic risk with next generation: mutation-positive parents' communication with their offspring in Lynch Syndrome. (20857224)
2011
27
Alu in Lynch syndrome: a danger SINE? (21972078)
2011
28
Characterization of germline mutations of MLH1 and MSH2 in unrelated south American suspected Lynch syndrome individuals. (21681552)
2011
29
Building a tool to identify risk for Lynch syndrome among individuals presenting for screening colonoscopy. (20349120)
2010
30
Magnetic resonance colonography for colorectal cancer screening in patients with Lynch syndrome gene mutation. (20495877)
2010
31
One to 2-year surveillance intervals reduce risk of colorectal cancer in families with Lynch syndrome. (20206180)
2010
32
Screening of the DNA mismatch repair genes MLH1, MSH2 and MSH6 in a Greek cohort of Lynch syndrome suspected families. (20937110)
2010
33
Hereditary breast and ovarian cancer (HBOC): clinical features and counseling for BRCA1 and BRCA2, Lynch syndrome, Cowden syndrome, and Li-Fraumeni syndrome. (20494261)
2010
34
Diagnosis and management of hereditary colorectal cancer syndromes: Lynch syndrome as a model. (19654196)
2009
35
Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. (19659756)
2009
36
Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome. (19156873)
2009
37
Early-onset breast cancer in a Lebanese family with Lynch syndrome due to MSH2 gene mutation. (19476642)
2009
38
Germline MLH1 and MSH2 mutations in Italian pancreatic cancer patients with suspected Lynch syndrome. (19728162)
2009
39
Estrogens, MSI and Lynch syndrome-associated tumors. (19559756)
2009
40
Intraductal papillary mucinous neoplasm of the pancreas with loss of mismatch repair in a patient with Lynch syndrome. (18987546)
2009
41
EGAPP supplementary evidence review: DNA testing strategies aimed at reducing morbidity and mortality from Lynch syndrome. (19125127)
2009
42
Lynch syndrome in women less than 50 years of age with endometrial cancer. (18448750)
2008
43
A frame-shift mutation of PMS2 is a widespread cause of Lynch syndrome. (18178629)
2008
44
Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics. (17312306)
2007
45
Immunohistochemical expression and microsatellite instability in Lynch syndrome]. (17628916)
2007
46
Prospective determination of prevalence of lynch syndrome in young women with endometrial cancer. (17925543)
2007
47
Some aspects of molecular diagnostics in Lynch syndrome. (20223024)
2006
48
Characterization of hMLH1 and hMSH2 gene dosage alterations in Lynch syndrome patients. (16143124)
2005
49
Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome? (16361634)
2005
50
Detection mutations in the DNA mismatch repair genes of hMLH1 and hMSH2 genes in Colombian families with suspicion of hereditary non-polyposis colorectal carcinoma (Lynch syndrome)]. (16276679)
2005

Genetic Variations for Lynch Syndrome

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Expression for genes affiliated with Lynch Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lynch Syndrome

Search GEO for disease gene expression data for Lynch Syndrome.

Pathways for genes affiliated with Lynch Syndrome

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5MSH2, PMS1, PMS2, MLH1, MLH3, MSH6
2
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.5BRCA1, BRCA2, MLH1, MSH6, MSH2
3
Hide members
10.5BRCA1, BRCA2, MLH1, MUTYH, MSH6, MSH2
410.5PMS2, BRCA1, BRCA2, MLH1
510.5MSH2, MLH1, APC, PMS2
6
Hide members
10.5BRCA1, MSH6, MSH2
7
Hide members
10.5BRCA1, BRCA2, MLH1, MLH3
8
Hide members
10.5BRAF, APC, MLH1, MSH6, MSH2
910.5BRCA1, BRCA2, BRAF, XRCC3, MSH6, MSH2
1010.5BRCA1, BRCA2, E2F2, MSH6, MSH2
11
Hide members
10.5BRCA1, BRCA2, LIG4
1210.5MSH6, APC, BRAF
13
Hide members
10.5BRCA1, BRCA2, E2F2, LIG4, MSH6, MSH2
14
Hide members
10.5MUTYH, LIG4, BRCA2, BRCA1
1510.5BRCA1, BRCA2, APC, CDKN2B
1610.5BRCA2, BRAF, APC, E2F2, MLH1, CDKN2B
17
Hide members
10.5E2F2, BRAF, BRCA2
18
Hide members
10.5BRCA2, XRCC3, XRCC2
19
Hide members
10.5BRCA1, BRCA2, BRAF, E2F2, CDKN2B, MSH6
2010.5BRAF, APC, E2F2
21
Hide members
10.5CDKN2B, E2F2, BRAF, BRCA2, BRCA1

Compounds for genes affiliated with Lynch Syndrome

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1crcs4410.9PMS2, BRAF, APC, MLH1, MSH6, MSH2
2paraffin4410.9PMS2, BRCA1, BRCA2, BRAF, APC, MLH1
3o6-methylguanine4410.9MSH2, BRCA2, BRAF, APC, MLH1, CDKN2B
4mononucleotide4410.9APC, MLH1, MSH6, MSH2
5cisplatin44 49 59 1113.9BRCA1, BRCA2, BRAF, XRCC3, XRCC2, MLH1
6mhs-24410.9PMS1, PMS2, MLH1
7p0034410.9BRCA1, BRCA2, XRCC3, MLH1, CDKN2B, EPCAM
8adenine44 11 2412.9BRCA1, BRAF, APC, MLH1, MUTYH, RNASE1
9sodium bisulfite4410.9BRCA1, APC, MLH1, CDKN2B
10n-methyl-n-nitrosourea4410.9MLH1, MSH6, MSH2
115-methylcytosine44 2411.9BRCA1, APC, MLH1, CDKN2B
128-oxoguanine4410.9BRCA1, BRCA2, APC, MUTYH
13camptothecin44 59 1112.9MLH1, XRCC2, XRCC3, BRCA2, BRCA1
14folate4410.9BRCA1, BRCA2, XRCC3, APC, MLH1
155-aza-2deoxycytidine4410.9PMS1, BRCA1, APC, MLH1, CDKN2B
16mnng4410.8APC, MLH1, MSH2
17polyacrylamide4410.8RNASE1, MLH1, APC, BRCA2, BRCA1
18biotin44 11 2412.8MSH2, MSH6, MLH1, PMS2
19mitomycin c4410.8XRCC2, XRCC3, BRCA2, BRCA1
20af/ap4410.8APC, MUTYH
21p0024410.8BRCA1, BRCA2, BRAF, MLH1
22oligonucleotide4410.8BRCA1, BRCA2, BRAF, APC, E2F2, RNASE1
23gold4410.8RNASE1, BRCA2
24methylmethanesulfonate4410.8APC, BRCA2, BRCA1
25proline4410.8BRCA1, BRCA2, MLH1, RNASE1, MSH2
26oligoribonucleotide4410.8RNASE1, RNASEL
275fluorouracil4410.8BRCA1, MLH1, EPCAM, MSH2
28threonine4410.8BRAF, APC, MLH1, CDKN2B, RNASE1, MSH6
29alanine4410.8BRCA1, BRAF, MLH1, LIG4, RNASE1, MSH2
30carboplatin44 49 1112.7MSH2, MLH1, BRCA1
31oxygen44 2411.7BRCA1, RNASE1, RNASEL
32retinoic acid44 2411.7BRCA1, BRCA2, BRAF, APC, MLH1, CDKN2B
33atp44 2811.7BRCA1, BRAF, MLH1, RNASE1, RNASEL, MSH2
34methionine4410.7MLH1, APC, XRCC3, BRCA1
35progesterone44 59 28 11 2414.6BRCA1, BRCA2, BRAF, APC, MLH1
36h2o24410.6BRCA1, BRCA2, MLH1, MUTYH, RNASE1
37paclitaxel44 49 1112.5MLH1, BRAF, BRCA2, BRCA1
38doxorubicin44 49 1112.5MSH2, MSH6, MLH1, BRCA1
39cytosine44 2411.5BRCA1, APC, MLH1
40serine4410.4BRCA1, BRAF, APC, CDKN2B, RNASE1, MSH6
41thymidylate4410.2BRCA1, MLH1, MSH2

GO Terms for genes affiliated with Lynch Syndrome

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16Gene Ontology
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Cellular components related to Lynch Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repair complexGO:03230010.7MLH3, MLH1, PMS2, PMS1
2MutLalpha complexGO:03238910.6PMS1, PMS2, MLH1
3MutLbeta complexGO:03239010.6MLH1, MLH3
4MutSalpha complexGO:03230110.6MSH6, MSH2
5chiasmaGO:00571210.5MLH1, MLH3
6synaptonemal complexGO:00079510.5MLH3, MLH1
7nucleusGO:00563410.4PMS1, PMS2, BRCA1, BRCA2, BRAF, XRCC3
8male germ cell nucleusGO:00167310.2MLH3, MLH1

Biological processes related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629810.9MSH2, MSH6, MUTYH, MLH3, MLH1, PMS2
2reciprocal meiotic recombinationGO:00713110.8MLH3, MLH1, PMS2, PMS1, MSH6
3somatic hypermutation of immunoglobulin genesGO:01644610.8PMS2, MSH2, MSH6, MLH1
4DNA repairGO:00628110.8BRCA1, BRCA2, XRCC3, XRCC2, LIG4, MUTYH
5isotype switchingGO:04519010.8LIG4, MLH1, MSH6, MSH2
6ATP catabolic processGO:00620010.8PMS1, MLH3, PMS2, MLH1, MSH6
7response to X-rayGO:01016510.8LIG4, BRCA2, XRCC2, MSH2
8somatic recombination of immunoglobulin gene segmentsGO:01644710.8MSH6, PMS2, MSH2
9double-strand break repairGO:00630210.8BRCA2, LIG4, MSH2, BRCA1
10intrinsic apoptotic signaling pathway in response to DNA damageGO:00863010.8MSH6, BRCA1, MLH1
11meiotic mismatch repairGO:00071010.7MSH2, MSH6
12response to gamma radiationGO:01033210.7BRCA2, XRCC2, LIG4
13double-strand break repair via homologous recombinationGO:00072410.7XRCC2, BRCA2, BRCA1
14positive regulation of helicase activityGO:05109610.7MSH2, MSH6
15maintenance of DNA repeat elementsGO:04357010.7MSH6, MSH2
16negative regulation of DNA recombinationGO:04591010.7MSH6, MSH2
17postreplication repairGO:00630110.6MSH2, BRCA1
18positive regulation of epithelial cell differentiationGO:03085810.6APC, CDKN2B
19determination of adult lifespanGO:00834010.6MSH6, MSH2
20negative regulation of neuron apoptotic processGO:04352410.5XRCC2, LIG4, MSH2
21chromosome organizationGO:05127610.5LIG4, APC
22DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.4BRCA1, BRCA2
23double-strand break repair via nonhomologous end joiningGO:00630310.2MLH1, LIG4

Molecular functions related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1MutSalpha complex bindingGO:03240710.8MUTYH, MLH3, MLH1, PMS2, PMS1
2single-stranded DNA bindingGO:00369710.8PMS1, PMS2, BRCA2, MLH1, MLH3, MSH2
3ATPase activityGO:01688710.8PMS1, PMS2, MLH1, MLH3, MSH6, MSH2
4mismatched DNA bindingGO:03098310.7PMS1, MLH3, MSH6, MSH2
5protein bindingGO:00551510.7E2F2, APC, XRCC2, XRCC3, BRAF, BRCA2
6ATP bindingGO:00552410.7PMS1, PMS2, BRAF, XRCC3, XRCC2, MLH1
7guanine/thymine mispair bindingGO:03213710.7MLH1, MSH6, MSH2
8DNA-dependent ATPase activityGO:00809410.6XRCC3, XRCC2, MSH6, MSH2
9MutLalpha complex bindingGO:03240510.6MSH2, MSH6, MUTYH
10single thymine insertion bindingGO:03214310.6MSH6, MSH2
11single guanine insertion bindingGO:03214210.6MSH2, MSH6
12oxidized purine DNA bindingGO:03235710.5MSH2, MSH6
13centromeric DNA bindingGO:01923710.5MSH2, MLH3
14four-way junction DNA bindingGO:00040010.4MSH6, MSH2
15DNA bindingGO:00367710.2PMS1, PMS2, BRCA1, XRCC3, XRCC2, E2F2

Products for genes affiliated with Lynch Syndrome

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  • Antibodies
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Sources for Lynch Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet