COCA1
MCID: LYN001
MIFTS: 70

Lynch Syndrome (COCA1) malady

Gastrointestinal diseases, Cancer diseases, Genetic diseases categories

Summaries for Lynch Syndrome

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21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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Genetics Home Reference:21 Lynch syndrome, often called hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited disorder that increases the risk of many types of cancer, particularly cancers of the colon (large intestine) and rectum, which are collectively referred to as colorectal cancer. People with Lynch syndrome also have an increased risk of cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, and skin. Additionally, women with this disorder have a high risk of cancer of the ovaries and lining of the uterus (the endometrium). People with Lynch syndrome may occasionally have noncancerous (benign) growths (polyps) in the colon, called colon polyps. In individuals with this disorder, colon polyps occur earlier but not in greater numbers than they do in the general population.

MalaCards: Lynch Syndrome, also known as hereditary nonpolyposis colorectal cancer, is related to colorectal cancer and adenoma. An important gene associated with Lynch Syndrome is PMS1 (PMS1 postmeiotic segregation increased 1 (S. cerevisiae)), and among its related pathways are Lagging Strand Synthesis and DNA damage Role of Brca1 and Brca2 in DNA repair. The compounds crcs and paraffin have been mentioned in the context of this disorder. Affiliated tissues include colon, brain and small intestine, and related mouse phenotypes are tumorigenesis and cellular.

NIH Rare Diseases:42 Lynch syndrome is an inherited condition that causes an increased risk of developing cancer. individuals with lynch syndrome have a higher risk of developing colon and rectal cancer, as well as cancers of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain, skin, and prostate. women with lynch syndrome also have a high risk of developing uterine cancer (also called endometrial cancer) and ovarian cancer. even though the disorder was originally described as not involving noncancerous (benign) growths (polyps) in the colon, people with lynch syndrome may occasionally have colon polyps. lynch syndrome has an autosomal dominant pattern of inheritance and is caused by a mutation in the mlh1, msh2, msh6, pms2 or epcam gene. last updated: 10/18/2013

Wikipedia:63 Lynch syndrome (HNPCC or hereditary nonpolyposis colorectal cancer ) is an autosomal dominant genetic... more...

Description from OMIM:46 613244,120435,609310

GeneReviews summary for hnpcc

Aliases & Classifications for Lynch Syndrome

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8Disease Ontology, 63Wikipedia, 19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Genetic diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

lynch syndrome 8 63 19 42 20 22 21 10 44
hereditary nonpolyposis colorectal cancer 8 63 42 21 60
familial nonpolyposis colon cancer 63 42 21
hnpcc 63 19 21
colon cancer, familial nonpolyposis 63 42
cancer family syndrome 63 21
colorectal cancer, hereditary nonpolyposis, type 1 60
hereditary defective mismatch repair syndrome 8
hereditary non-polyposis colon cancer type 1 8
hnpcc - hereditary nonpolyposis colon cancer 8
hereditary nonpolyposis colorectal neoplasms 21
hereditary nonpolyposis colorectal neoplasm 8
colorectal cancer, hereditary nonpolyposis 42
hereditary non-polyposis colon cancer 19
hereditary nonpolyposis colon cancer 44
lynch cancer family syndrome 2 60
coca 1 8
coca1 42


External Ids:

Disease Ontology8 DOID:3883
SNOMED-CT56 315058005
MeSH34 D003123

Related Diseases for Lynch Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Lynch Syndrome family:

Mlh1-Related Lynch Syndrome Msh2-Related Lynch Syndrome
Msh6-Related Lynch Syndrome Pms2-Related Lynch Syndrome
Epcam-Related Lynch Syndrome Mlh3-Related Lynch Syndrome
Pms1-Related Lynch Syndrome

Diseases related to Lynch Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1colorectal cancer31.5PMS1, PMS2, BRAF, APC, MLH1, MUTYH
2adenoma30.8APC, BRAF, BRCA1, MLH1, MUTYH, MSH6
3colon cancer30.7APC, BRAF, MSH2, EPCAM, MLH1, MSH6
4breast cancer30.6MSH2, EPCAM, MSH6, BRCA1, BRCA2
5adenocarcinoma30.6PMS2, MSH2, BRCA1, EPCAM, BRAF, XRCC3
6familial adenomatous polyposis30.6PMS2, PMS1, MSH2, BRCA1, MSH6, MUTYH
7ovarian cancer30.6MSH2, EPCAM, MLH1, BRAF, BRCA2, BRCA1
8prostate cancer30.5PMS1, PMS2, BRCA1, BRCA2, APC, LIG4
9endometrial carcinoma30.5BRCA2, MSH2, MLH1, BRAF, BRCA1, MSH6
10melanoma30.4MSH2, EPCAM, PMS1, PMS2, RNASE1, BRCA2
11retinoblastoma30.4PMS1, BRCA1, APC, CDKN2B, BRCA2, EPCAM
12male breast cancer30.4BRCA2, BRCA1
13gastric cancer, somatic30.4MUTYH, APC
14muir-torre syndrome30.4MSH6, MLH1, C3orf35, MSH2
15pancreatic cancer30.2MSH2, RNASE1, EPCAM, MLH1, BRAF, BRCA2
16pancreatitis30.2BRCA2, RNASE1
17turcot syndrome30.2PMS2, MLH1
18transitional cell carcinoma30.2MLH1, CDKN2B, MSH2
19neurofibromatosis30.1MSH2, MLH1, BRCA2, PMS2, MSH6
20thyroid cancer29.9BRAF, APC
21li-fraumeni syndrome29.9BRCA1, MLH1, BRCA2
22hepatocellular carcinoma29.9APC, EPCAM, CDKN2B, MUTYH, BRCA2
23brca1 and brca2 hereditary breast and ovarian cancer29.9BRCA1, BRCA2
24brain cancer29.9CDKN2B, APC, MSH2, MSH6
25oligodendroglioma29.9BRAF, CDKN2B
26sarcoma29.9MLH1, MSH2, BRCA2, BRAF
27hematologic cancer29.9MSH2, MLH1, CDKN2B, MSH6
28keratoacanthoma29.9MSH2, MLH1
29colorectal cancer, hereditary nonpolyposis, type 810.5
30colorectal cancer, hereditary nonpolyposis, type 510.5
31colorectal cancer, hereditary nonpolyposis, type 610.5
32colorectal cancer, hereditary nonpolyposis, type 210.5
33colorectal cancer, hereditary nonpolyposis, type 410.5
34colorectal cancer, hereditary nonpolyposis, type 710.5
35prostatitis10.4
36non-hodgkin lymphoma10.3
37hereditary hemorrhagic telangiectasia10.3
38lymphoepithelioma-like carcinoma10.3
39uterine carcinosarcoma10.3
40duodenitis10.3
41liposarcoma10.3
42pleomorphic rhabdomyosarcoma10.3
43rhabdomyosarcoma10.3
44ciliary dyskinesia, primary, 2710.3
45colorectal cancer, hereditary nonpolyposis, type 110.3
46hereditary breast ovarian cancer10.1
47endometriosis10.1
48peritonitis10.1
49mlh1-related lynch syndrome10.1
50msh2-related lynch syndrome10.1

Graphical network of the top 20 diseases related to Lynch Syndrome:



Diseases related to lynch syndrome

Clinical Features for Lynch Syndrome

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46OMIM
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Clinical features from OMIM:

613244,120435,609310

Drugs & Therapeutics for Lynch Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Lynch Syndrome

Drug clinical trials:

Search ClinicalTrials for Lynch Syndrome

Search NIH Clinical Center for Lynch Syndrome

Search CenterWatch for Lynch Syndrome

Genetic Tests for Lynch Syndrome

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20GeneTests, 22GTR
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Genetic tests related to Lynch Syndrome:

id Genetic test Affiliating Genes
1 Lynch Syndrome20 22

Anatomical Context for Lynch Syndrome

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32MalaCards
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MalaCards organs/tissues related to Lynch Syndrome:

32
Colon, Brain, Small intestine, Skin, Ovary, Testes, Liver, Prostate, Uterus, Breast, Kidney, Pancreas, Lung, Thyroid

Animal Models for Lynch Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Lynch Syndrome:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.7MSH2, PMS1, PMS2, BRAF, MLH1, CDKN2B
2MP:000538410.7APC, XRCC2, BRAF, BRCA2, BRCA1, PMS2
3MP:001076810.7APC, XRCC2, BRAF, BRCA2, BRCA1, PMS2
4MP:001077110.6BRCA1, BRCA2, XRCC2, APC, E2F2, CDKN2B
5MP:000537610.6PMS2, BRCA1, BRCA2, XRCC2, LIG4, MUTYH
6MP:000538110.6PMS2, BRCA1, BRCA2, BRAF, APC, MLH1
7MP:000539710.5PMS2, BRCA1, BRCA2, BRAF, APC, E2F2
8MP:000537910.5PMS2, BRCA1, BRCA2, MLH1, MLH3, CDKN2B
9MP:000363110.5EPCAM, MUTYH, LIG4, APC
10MP:000538710.4PMS2, BRCA1, BRCA2, BRAF, APC, E2F2
11MP:000538910.2BRCA1, BRCA2, BRAF, APC, MLH1, MLH3

Publications for Lynch Syndrome

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50PubMed
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Articles related to Lynch Syndrome:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Epithelial-mesenchymal transition in colorectal cancer tissue of patients with Lynch syndrome. (24415879)
2014
2
Colorectal surveillance in Lynch syndrome families. (23525799)
2013
3
Patients with Lynch syndrome mismatch repair gene mutations are at higher risk for not only upper tract urothelial cancer but also bladder cancer. (22883484)
2013
4
Genetic Testing Strategies in Newly Diagnosed Endometrial Cancer Patients Aimed at Reducing Morbidity or Mortality from Lynch Syndrome in the Index Case or Her Relatives. (24056992)
2013
5
Ureteroscopic management of upper tract urothelial carcinoma (UTUC) in patients with Lynch Syndrome (hereditary nonpolyposis colorectal cancer syndrome). (23452166)
2013
6
Refining the role of PMS2 in Lynch syndrome: germline mutational analysis improved by comprehensive assessment of variants. (23709753)
2013
7
Improving identification of lynch syndrome patients: a comparison of research data with clinical records. (23225370)
2013
8
Chemoprevention of endometrial cancer in Lynch syndrome: a step forward. (23842794)
2013
9
Re: Risks of colorectal and other cancers after endometrial cancer for women with Lynch syndrome. (24168969)
2013
10
Genetic variant in the telomerase gene modifies cancer risk in Lynch syndrome. (22948024)
2013
11
Functional analysis in mouse embryonic stem cells reveals wild-type activity for three MSH6 variants found in suspected Lynch syndrome patients. (24040339)
2013
12
Hereditary nonpolyposis colorectal cancer (Lynch syndrome I) in a 15-year-old male. (22200794)
2012
13
Evidence for breast cancer as an integral part of Lynch syndrome. (22034109)
2012
14
Influence of patient preferences on the cost-effectiveness of screening for Lynch syndrome. (22694112)
2012
15
Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases. (22691310)
2012
16
Bethesda criteria for microsatellite instability testing: impact on the detection of new cases of Lynch syndrome. (22776989)
2012
17
Novel germline MSH2 mutation in lynch syndrome patient surviving multiple cancers. (22234272)
2012
18
Is breast cancer a part of Lynch syndrome? (22913763)
2012
19
Tumor spectrum in lynch syndrome, DNA mismatch repair system and endogenous carcinogens. (22275225)
2012
20
Testing women with endometrial cancer to detect Lynch syndrome. (21537049)
2011
21
The accuracy of risks for cancer in Lynch syndrome. (21883164)
2011
22
Lynch syndrome in Tunisia: first description of clinical features and germline mutations. (21311894)
2011
23
Colorectal cancer susceptibility loci on chromosome 8q23.3 and 11q23.1 as modifiers for disease expression in Lynch syndrome. (21097774)
2011
24
Early-onset colorectal cancer is an easy and effective tool to identify retrospectively Lynch syndrome. (21590452)
2011
25
Novel MLH1 duplication identified in Colombian families with Lynch syndrome. (21233718)
2011
26
Factors affecting encouragement of relatives among families with Lynch syndrome to seek medical assessment. (21695501)
2011
27
Carcinoma of the Lower Uterine Segment (LUS): Clinicopathological Characteristics and Association with Lynch Syndrome. (21886452)
2011
28
Colonoscopy use following mutation detection in Lynch syndrome: exploring a role for cancer screening in adaptation. (21204803)
2011
29
Who should have genetic testing for the Lynch syndrome? (21768586)
2011
30
Limited impact on self-concept in individuals with Lynch syndrome; results from a national cohort study. (21691837)
2011
31
Frequency of extracolonic tumors in Brazilian families with Lynch syndrome: analysis of a hereditary colorectal cancer institutional registry. (20697958)
2010
32
Identification of Lynch syndrome mutations in the MLH1-PMS2 interface that disturb dimerization and mismatch repair. (20533529)
2010
33
Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with Lynch syndrome. (19957108)
2010
34
Risk of urothelial bladder cancer in Lynch syndrome is increased, in particular among MSH2 mutation carriers. (20591884)
2010
35
Contribution of ultrasonography to endometrial cancer screening in patients with hereditary nonpolyposis colorectal cancer/Lynch syndrome. (20686377)
2010
36
Effectiveness of each Bethesda marker in defining microsatellite instability when screening for Lynch syndrome. (19621678)
2009
37
Deletions removing the last exon of TACSTD1 constitute a distinct class of mutations predisposing to Lynch syndrome. (19177550)
2009
38
Mutation prediction models in Lynch syndrome: evaluation in a clinical genetic setting. (19541685)
2009
39
Somatic mosaicism in a patient with Lynch syndrome. (19133695)
2009
40
Underutilization of microsatellite instability analysis in colorectal cancer patients at high risk for Lynch syndrome. (19153873)
2009
41
Management of extracolonic tumours in patients with Lynch syndrome. (19341971)
2009
42
Sessile serrated polyps of the colorectum are rare in patients with Lynch syndrome and in familial colorectal cancer families. (17929199)
2008
43
Syndromic colon cancer: lynch syndrome and familial adenomatous polyposis. (18313539)
2008
44
Missed adenomas during colonoscopic surveillance in individuals with Lynch Syndrome (hereditary nonpolyposis colorectal cancer). (19138994)
2008
45
The clinical phenotype of Lynch syndrome due to germ-line PMS2 mutations. (18602922)
2008
46
Review article: The Lynch syndrome (hereditary nonpolyposis colorectal cancer). (18081655)
2007
47
A new variant database for mismatch repair genes associated with Lynch syndrome. (17347989)
2007
48
New aspects in molecular diagnosis of Lynch syndrome (HNPCC). (17192058)
2006
49
Tobacco use and increased colorectal cancer risk in patients with hereditary nonpolyposis colorectal cancer (Lynch syndrome). (15596632)
2004
50
The Muir-Torre syndrome in kindreds with hereditary nonpolyposis colorectal cancer (Lynch syndrome): A classic obligation in preventive medicine. (10534651)
1999

Genetic Variations for Lynch Syndrome

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Expression for genes affiliated with Lynch Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Lynch Syndrome

Search GEO for disease gene expression data for Lynch Syndrome.

Pathways for genes affiliated with Lynch Syndrome

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
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Pathways related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 21)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5MSH2, PMS1, PMS2, MLH1, MLH3, MSH6
2
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.5BRCA1, BRCA2, MLH1, MSH6, MSH2
3
Hide members
10.5BRCA1, BRCA2, MLH1, MUTYH, MSH6, MSH2
410.5PMS2, BRCA1, BRCA2, MLH1
510.5MSH2, MLH1, APC, PMS2
6
Hide members
10.5BRCA1, MSH6, MSH2
7
Hide members
10.5BRCA1, BRCA2, MLH1, MLH3
8
Hide members
10.5BRAF, APC, MLH1, MSH6, MSH2
910.5BRCA1, BRCA2, BRAF, XRCC3, MSH6, MSH2
1010.5BRCA1, BRCA2, E2F2, MSH6, MSH2
11
Hide members
10.5BRCA1, BRCA2, LIG4
1210.5MSH6, APC, BRAF
13
Hide members
10.5BRCA1, BRCA2, E2F2, LIG4, MSH6, MSH2
14
Hide members
10.5MUTYH, LIG4, BRCA2, BRCA1
1510.5BRCA1, BRCA2, APC, CDKN2B
1610.5BRCA2, BRAF, APC, E2F2, MLH1, CDKN2B
17
Hide members
10.5E2F2, BRAF, BRCA2
18
Hide members
10.5BRCA2, XRCC3, XRCC2
19
Hide members
10.5BRCA1, BRCA2, BRAF, E2F2, CDKN2B, MSH6
2010.5BRAF, APC, E2F2
21
Hide members
10.5CDKN2B, E2F2, BRAF, BRCA2, BRCA1

Compounds for genes affiliated with Lynch Syndrome

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44Novoseek, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 41)
idCompoundScoreTop Affiliating Genes
1crcs4410.9PMS2, BRAF, APC, MLH1, MSH6, MSH2
2paraffin4410.9PMS2, BRCA1, BRCA2, BRAF, APC, MLH1
3o6-methylguanine4410.9MSH2, BRCA2, BRAF, APC, MLH1, CDKN2B
4mononucleotide4410.9APC, MLH1, MSH6, MSH2
5cisplatin44 49 59 1113.9BRCA1, BRCA2, BRAF, XRCC3, XRCC2, MLH1
6mhs-24410.9PMS1, PMS2, MLH1
7p0034410.9BRCA1, BRCA2, XRCC3, MLH1, CDKN2B, EPCAM
8adenine44 11 2412.9BRCA1, BRAF, APC, MLH1, MUTYH, RNASE1
9sodium bisulfite4410.9BRCA1, APC, MLH1, CDKN2B
10n-methyl-n-nitrosourea4410.9MLH1, MSH6, MSH2
115-methylcytosine44 2411.9BRCA1, APC, MLH1, CDKN2B
128-oxoguanine4410.9BRCA1, BRCA2, APC, MUTYH
13camptothecin44 59 1112.9MLH1, XRCC2, XRCC3, BRCA2, BRCA1
14folate4410.9BRCA1, BRCA2, XRCC3, APC, MLH1
155-aza-2deoxycytidine4410.9PMS1, BRCA1, APC, MLH1, CDKN2B
16mnng4410.8APC, MLH1, MSH2
17polyacrylamide4410.8RNASE1, MLH1, APC, BRCA2, BRCA1
18biotin44 11 2412.8MSH2, MSH6, MLH1, PMS2
19mitomycin c4410.8XRCC2, XRCC3, BRCA2, BRCA1
20af/ap4410.8APC, MUTYH
21p0024410.8BRCA1, BRCA2, BRAF, MLH1
22oligonucleotide4410.8BRCA1, BRCA2, BRAF, APC, E2F2, RNASE1
23gold4410.8RNASE1, BRCA2
24methylmethanesulfonate4410.8APC, BRCA2, BRCA1
25proline4410.8BRCA1, BRCA2, MLH1, RNASE1, MSH2
26oligoribonucleotide4410.8RNASE1, RNASEL
275fluorouracil4410.8BRCA1, MLH1, EPCAM, MSH2
28threonine4410.8BRAF, APC, MLH1, CDKN2B, RNASE1, MSH6
29alanine4410.8BRCA1, BRAF, MLH1, LIG4, RNASE1, MSH2
30carboplatin44 49 1112.7MSH2, MLH1, BRCA1
31oxygen44 2411.7BRCA1, RNASE1, RNASEL
32retinoic acid44 2411.7BRCA1, BRCA2, BRAF, APC, MLH1, CDKN2B
33atp44 2811.7BRCA1, BRAF, MLH1, RNASE1, RNASEL, MSH2
34methionine4410.7MLH1, APC, XRCC3, BRCA1
35progesterone44 59 28 11 2414.6BRCA1, BRCA2, BRAF, APC, MLH1
36h2o24410.6BRCA1, BRCA2, MLH1, MUTYH, RNASE1
37paclitaxel44 49 1112.5MLH1, BRAF, BRCA2, BRCA1
38doxorubicin44 49 1112.5MSH2, MSH6, MLH1, BRCA1
39cytosine44 2411.5BRCA1, APC, MLH1
40serine4410.4BRCA1, BRAF, APC, CDKN2B, RNASE1, MSH6
41thymidylate4410.2BRCA1, MLH1, MSH2

GO Terms for genes affiliated with Lynch Syndrome

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16Gene Ontology
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Cellular components related to Lynch Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mismatch repair complexGO:03230010.7MLH3, MLH1, PMS2, PMS1
2MutLalpha complexGO:03238910.6PMS1, PMS2, MLH1
3MutLbeta complexGO:03239010.6MLH1, MLH3
4MutSalpha complexGO:03230110.6MSH6, MSH2
5chiasmaGO:00571210.5MLH1, MLH3
6synaptonemal complexGO:00079510.5MLH3, MLH1
7nucleusGO:00563410.4PMS1, PMS2, BRCA1, BRCA2, BRAF, XRCC3
8male germ cell nucleusGO:00167310.2MLH3, MLH1

Biological processes related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1mismatch repairGO:00629810.9MSH2, PMS1, PMS2, MLH1, MLH3, MUTYH
2reciprocal meiotic recombinationGO:00713110.8PMS1, PMS2, MLH1, MLH3, MSH6
3somatic hypermutation of immunoglobulin genesGO:01644610.8MSH2, MSH6, MLH1, PMS2
4DNA repairGO:00628110.8BRCA1, BRCA2, XRCC3, XRCC2, LIG4, MUTYH
5isotype switchingGO:04519010.8MLH1, LIG4, MSH6, MSH2
6ATP catabolic processGO:00620010.8MSH6, MLH3, MLH1, PMS2, PMS1
7response to X-rayGO:01016510.8BRCA2, XRCC2, LIG4, MSH2
8somatic recombination of immunoglobulin gene segmentsGO:01644710.8PMS2, MSH6, MSH2
9double-strand break repairGO:00630210.8MSH2, LIG4, BRCA2, BRCA1
10intrinsic apoptotic signaling pathway in response to DNA damageGO:00863010.8MSH6, MLH1, BRCA1
11meiotic mismatch repairGO:00071010.7MSH2, MSH6
12response to gamma radiationGO:01033210.7BRCA2, XRCC2, LIG4
13double-strand break repair via homologous recombinationGO:00072410.7XRCC2, BRCA2, BRCA1
14positive regulation of helicase activityGO:05109610.7MSH6, MSH2
15maintenance of DNA repeat elementsGO:04357010.7MSH6, MSH2
16postreplication repairGO:00630110.7MSH2, BRCA1
17positive regulation of epithelial cell differentiationGO:03085810.6CDKN2B, APC
18negative regulation of DNA recombinationGO:04591010.6MSH2, MSH6
19determination of adult lifespanGO:00834010.6MSH6, MSH2
20negative regulation of neuron apoptotic processGO:04352410.5MSH2, LIG4, XRCC2
21chromosome organizationGO:05127610.5LIG4, APC
22DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.4BRCA1, BRCA2
23double-strand break repair via nonhomologous end joiningGO:00630310.2LIG4, MLH1

Molecular functions related to Lynch Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1MutSalpha complex bindingGO:03240710.8MUTYH, MLH3, MLH1, PMS2, PMS1
2single-stranded DNA bindingGO:00369710.8PMS1, PMS2, BRCA2, MLH1, MLH3, MSH2
3ATPase activityGO:01688710.8PMS1, PMS2, MLH1, MLH3, MSH6, MSH2
4mismatched DNA bindingGO:03098310.7PMS1, MLH3, MSH6, MSH2
5protein bindingGO:00551510.7E2F2, APC, XRCC2, XRCC3, BRAF, BRCA2
6ATP bindingGO:00552410.7PMS1, PMS2, BRAF, XRCC3, XRCC2, MLH1
7guanine/thymine mispair bindingGO:03213710.7MLH1, MSH6, MSH2
8DNA-dependent ATPase activityGO:00809410.6XRCC3, XRCC2, MSH6, MSH2
9MutLalpha complex bindingGO:03240510.6MSH2, MSH6, MUTYH
10single thymine insertion bindingGO:03214310.6MSH6, MSH2
11single guanine insertion bindingGO:03214210.6MSH2, MSH6
12oxidized purine DNA bindingGO:03235710.5MSH2, MSH6
13centromeric DNA bindingGO:01923710.5MSH2, MLH3
14four-way junction DNA bindingGO:00040010.4MSH6, MSH2
15DNA bindingGO:00367710.2PMS1, PMS2, BRCA1, XRCC3, XRCC2, E2F2

Products for genes affiliated with Lynch Syndrome

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Sources for Lynch Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet