Aliases & Classifications for Macrocytic Anemia

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Sources:
8Disease Ontology, 44Novoseek, 61UMLS, 56SNOMED-CT, 33MeSH, 39NCIt
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Aliases & Descriptions for Macrocytic Anemia:

Name: Macrocytic Anemia 8
Anemia Macrocytic 8 44
Macrocytic Anaemia of Unspecified Cause 8
 
Macrocytic Anemia of Unspecified Cause 8
Anemia, Macrocytic 61


External Ids:

Disease Ontology8 DOID:2361
MeSH33 D000748
NCIt39 C34381

Summaries for Macrocytic Anemia

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Wikipedia:64 The term macrocytic is from Greek words meaning \"large cell\". A macrocytic class of anemia is an... more...

MalaCards based summary: Macrocytic Anemia, also known as anemia macrocytic, is related to diamond-blackfan anemia 1 and diamond-blackfan anemia. An important gene associated with Macrocytic Anemia is TCN2 (transcobalamin II), and among its related pathways are Metabolism of porphyrins and p53 Pathway. The compounds hydroxymethylbilane and protoporphyrinogen have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and bone marrow.

Related Diseases for Macrocytic Anemia

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Diseases related to Macrocytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1diamond-blackfan anemia 130.7RPS19
2diamond-blackfan anemia28.6RPL11, RPS7, RPL5, RPS19, RPS17, RPS10
3pernicious anemia10.6
4macrocytic anemia, refractory, due to 5q deletion, somatic10.5
5acute erythroid leukemia10.4
6leukemia10.4
7thrombocytosis10.4
8tropical sprue10.4
9porphyria, congenital erythropoietic10.3FECH, UROD
10diamond-blackfan anemia 710.3
11diamond-blackfan anemia 610.3
12thiamine-responsive megaloblastic anemia syndrome10.3
13diamond-blackfan anemia 810.3
14diamond-blackfan anemia 1210.3
15myelodysplastic syndrome10.3
16diamond-blackfan anemia 510.3
17diamond-blackfan anemia 310.3
18combined oxidative phosphorylation deficiency 1810.3
19diamond-blackfan anemia 410.3
20shwachman-bodian-diamond syndrome10.3
21acute leukemia10.3
22thrombocytopenia10.3
23steatorrhea10.3
24megaloblastic anemia10.3
25glossitis10.3
2616q24.3 microdeletion syndrome10.3
27coproporphyria10.3UROD, FECH
28porphyria, acute intermittent10.2UROD, FECH
29porphyria variegata10.2FECH, UROD
30porphyria10.1UROD, FECH
31aplastic anemia10.1RPS14, RPS19
32rheumatoid arthritis10.1
33diamond-blackfan anemia 910.1
34diamond-blackfan anemia 210.1
35cartilage-hair hypoplasia10.1
36diamond-blackfan anemia 1110.1
37transcobalamin ii deficiency10.1
38anemia, sideroblastic, x-linked10.1
39malaria10.1
40celiac disease10.1
41multiple myeloma10.1
42dyserythropoietic anemia, congenital, type ib10.1
43dyserythropoietic anemia, congenital, type ia10.1
44dyserythropoietic anemia, congenital, type iii10.1
45anemia, x-linked, with/without neutropenia and/or platelet abnormalities10.1
46alcohol abuse10.1
47arthritis10.1
48bipolar disorder10.1
49hepatitis10.1
50ischemic optic neuropathy10.1

Graphical network of the top 20 diseases related to Macrocytic Anemia:



Diseases related to macrocytic anemia

Symptoms for Macrocytic Anemia

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Drugs & Therapeutics for Macrocytic Anemia

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Drug clinical trials:

Search ClinicalTrials for Macrocytic Anemia

Search NIH Clinical Center for Macrocytic Anemia

Genetic Tests for Macrocytic Anemia

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Anatomical Context for Macrocytic Anemia

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MalaCards organs/tissues related to Macrocytic Anemia:

31
Liver, Small intestine, Bone marrow, Bone, Testes, Neutrophil

Animal Models for Macrocytic Anemia or affiliated genes

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Publications for Macrocytic Anemia

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Articles related to Macrocytic Anemia:

(show top 50)    (show all 132)
idTitleAuthorsYear
1
Macrocytic anemia and thrombocytopenia induced by orlistat. (24719628)
2013
2
Intractable epilepsy as the presentation of vitamin B deficiency in the absence of macrocytic anemia. (16026570)
2005
3
Life-threatening maternal and fetal macrocytic anemia from antiretroviral therapy. (16260567)
2005
4
87-year-old man with macrocytic anemia. (11213309)
2001
5
Macrocytic anemia and thrombocytosis associated with thymoma: a case report. (10602167)
2000
6
Dose-related thrombocytopenia and macrocytic anemia associated with valproate use in bipolar disorder. (9108818)
1997
7
Vitamin supplements improve the fertility potential of a subfertile male with macrocytic anemia--a case study. (7795372)
1994
8
Partial amelioration of AZT-induced macrocytic anemia in the mouse by folic acid. (8241950)
1993
9
A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. (1578958)
1992
10
Anterior ischemic optic neuropathy associated with macrocytic anemia. (2150841)
1990
11
Macrocytic anemia. (3821094)
1987
12
A cobalamin metabolic defect with homocystinuria, methylmalonic aciduria and macrocytic anemia. (2873525)
1986
13
Gametic and pleiotropic defects in mouse fetuses with Hertwig's macrocytic anemia. (4018402)
1985
14
Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes: the 5q-syndrome, a distinct entity. (453227)
1979
15
Cytochemical study of granulopoietic tissue. 3. Megaloblastic and macrocytic anemia. (5020392)
1972
16
Vitamin E-responsive macrocytic anemia in protein-calorie malnutrition. Measurements of vitamin E, folic acid, vitamin C, vitamin B12 and iron. (5006442)
1966
17
KWASHIORKOR IN EGYPT. II. HEMATOLOGIC ASPECTS (THE OCCURENCE OF A MACROCYTIC ANEMIA ASSOCIATED WITH LOW SERUM VITAMIN E AND A WIDE RANGE OF SERUM VITAMIN B12 LEVELS). (14322834)
1965
18
VITAMIN E RESPONSIVE MACROCYTIC ANEMIA. (14064339)
1963
19
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (14447714)
1961
20
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (13736665)
1961
21
Macrocytic anemia in aged. II. Blood & bone marrow changes in 65 elderly anemia patients]. (13613532)
1958
22
PITTING edema associated with nutritional macrocytic anemia. (14371228)
1955
23
Absorption of radioactive vitamin B12 after total gastrectomy; relation to macrocytic anemia and to the site of origin of Castle's intrinsic factor. (13185389)
1954
24
Macrocytic anemia associated with intestinal strictures and anastomoses: report of two cases. (13139137)
1954
25
Hypochromic and macrocytic anemia due to Anguillula intestinalis infestation, simulating saturnine anemia]. (13134861)
1953
26
Experimental production of nutritional macrocytic anemia in swine. V. Hematologic manifestations of a combined deficiency of vitamin B12 and pteroylglutamic acid. (12977830)
1952
27
A case history presenting an interesting macrocytic anemia of unknown etiology. (12988144)
1952
28
A case of macrocytic anemia in a dog. (14905888)
1952
29
Macrocytic anemia and Sato's bromsulfalein test in children with nutritional dystrophy. (13038764)
1952
30
FOLIC acid deficiency in macrocytic anemia of pregnancy and infancy. (14907394)
1952
31
Experimental anemias in the rat; I. Macrocytic anemia in chronic pteroylglutamic acid deficiency and after splenectomy in Bartonella muris infection. (15414205)
1950
32
Macrocytic anemia and impaired liver function in eczematous and certain other dermatoses. (14782693)
1950
33
Hemolytic macrocytic anemia. (15406291)
1950
34
Experimental production of a nutritional macrocytic anemia in swine. (15410775)
1950
35
Observations on the macrocytic anemia associated with pregnancy. (18131962)
1949
36
Macrocytic anemia of pregnancy refractory to vitamin B12 therapy; response to treatment with folic acid; report of case. (18115522)
1949
37
Neurologic sequelae in macrocytic anemia of gastrointestinal origin following folic acid therapy. (18889324)
1948
38
Macrocytic anemia; report of a case one month postpartum. (18857036)
1948
39
The effect of liver extract and vitamin B12 on the mucous membrane lesions of macrocytic anemia. (18877051)
1948
40
Pernicious anemia, nutritional macrocytic anemia, and tropical sprue. (18920890)
1948
41
Macrocytic anemia of pregnancy; review of literature and report of a case treated with folic acid. (18105406)
1948
42
Macrocytic anemia. (18858389)
1948
43
Vitamin B12 in pernicious anemia and puerperal macrocytic anemia. (18890061)
1948
44
Metabolic function of pteroylglutamic acid and its hexaglutamyl conjugate; hematologic and urinary excretion studies on patients with macrocytic anemia. (20279937)
1947
45
The effect of folic acid on the blood picture in human macrocytic anemia. (21064560)
1946
46
FOLIC acid in macrocytic anemia. (21027185)
1946
47
Acute macrocytic anemia in the newborn, with special reference to its relation to erythroblastosis foetalis. (20254636)
1946
48
Further studies on folic acid in the treatment of macrocytic anemia. (21004150)
1945
49
SPONTANEOUS RECOVERY FROM NUTRITIONAL MACROCYTIC ANEMIA IN YOUNG SWINE FOLLOWING INITIAL ESTRUS. (16694844)
1941
50
COMPARISON OF HEMATOPOIESIS IN THE FETUS AND DURING RECOVERY FROM PERNICIOUS ANEMIA: TOGETHER WITH A CONSIDERATION OF THE RELATIONSHIP OF FETAL HEMATOPOIESIS TO MACROCYTIC ANEMIA OF PREGNANCY AND ANEMIA IN INFANTS. (16694355)
1935

Variations for Macrocytic Anemia

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Expression for genes affiliated with Macrocytic Anemia

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Search GEO for disease gene expression data for Macrocytic Anemia.

Pathways for genes affiliated with Macrocytic Anemia

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Pathways related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
tetrapyrrole biosynthesis36
heme degradation36
Heme Biosynthesis36
heme biosynthesis36
heme biosynthesis from uroporphyrinogen-III I36
9.9FECH, UROD
2
Show member pathways
p53 pathway36
9.7RPL11, RPL5
3
Show member pathways
6.9RPS14, RPS26, RPS7, RPS19, RPS17, RPS10
4
Show member pathways
5.8RPS26, RPS7, RPS14, RPL11, RPS24, RPL35A
5
Show member pathways
5.8RPL11, RPS26, RPS24, RPL35A, RPS10, RPS17
6
Show member pathways
Cytoplasmic Ribosomal Proteins36
5.8RPS7, RPS14, RPL5, RPS19, RPS10, RPL35A
7
Show member pathways
5.8RPS26, RPL11, RPS24, RPL35A, RPS10, RPS17
85.6RPS24, RPL35A, RPS10, RPS17, RPS19, RPL5

Compounds for genes affiliated with Macrocytic Anemia

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Sources:
44Novoseek, 24HMDB, 11DrugBank
See all sources

Compounds related to Macrocytic Anemia according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1hydroxymethylbilane44 2411.2UROD, FECH
2protoporphyrinogen4410.1FECH, UROD
3uroporphyrinogen-iii4410.1FECH, UROD
4pyrrole4410.1UROD, FECH
5formyl-coa44 2411.1UROD, FECH
6porphyrin4410.0UROD, FECH
7porphobilinogen44 24 1112.0UROD, FECH
8vitamin b6449.9TCN2, FECH
9protoporphyrin ix44 24 1111.9FECH, UROD
10haem449.8UROD, FECH
115-aminolevulinic acid44 2410.6UROD, FECH
12iron44 2410.5SFXN4, FECH, UROD, CDAN1
13rrna449.2RPL11, RPS19, RPL5

GO Terms for genes affiliated with Macrocytic Anemia

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Cellular components related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1small ribosomal subunitGO:00159359.7RPS24, RPS26
2cytosolic large ribosomal subunitGO:00226259.2RPL5, RPL35A, RPL11
3ribosomeGO:00058408.3RPS7, RPS19, RPS17, RPS10
4extracellular vesicular exosomeGO:00700627.4RPL11, RPL35A, RPS19, RPL5, RPS14, RPS26
5cytosolic small ribosomal subunitGO:00226277.1RPS24, RPS26, RPS7, RPS14, RPS19, RPS17
6nucleolusGO:00057306.5RPS26, RPS7, RPS14, RPL5, RPS19, RPS10
7cytosolGO:00058295.7UROD, RPS26, RPS7, RPS14, RPL5, RPS19

Biological processes related to Macrocytic Anemia according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1iron ion homeostasisGO:00550729.9FECH, SFXN4
2porphyrin-containing compound metabolic processGO:00067789.8FECH, UROD
3erythrocyte homeostasisGO:00341019.7RPS24, RPS17
4heme biosynthetic processGO:00067839.6UROD, FECH
5ribosomal large subunit biogenesisGO:00422739.5RPL11, RPL35A, RPL5
6maturation of SSU-rRNAGO:00304909.2RPS14, RPS19
7maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)GO:00004629.2RPS24, RPS19
8ribosomal small subunit assemblyGO:00000289.0RPS19, RPS17, RPS14
9erythrocyte differentiationGO:00302189.0RPS19, FECH, RPS14
10ribosomal small subunit biogenesisGO:00422748.4RPS19, RPS7, RPS17, RPS24
11rRNA processingGO:00063647.3RPL5, RPS7, RPS19, RPS17, RPL35A, RPS24
12translational terminationGO:00064156.2RPS10, RPS17, RPS19, RPL5, RPS14, RPS7
13SRP-dependent cotranslational protein targeting to membraneGO:00066146.2RPS7, RPS26, RPS14, RPL5, RPS19, RPL11
14viral transcriptionGO:00190836.2RPS7, RPS14, RPL5, RPS19, RPS17, RPS10
15viral life cycleGO:00190586.2RPS26, RPS7, RPS14, RPL11, RPS24, RPL5
16mRNA metabolic processGO:00160716.2RPS24, RPL35A, RPS10, RPS17, RPS19, RPL5
17RNA metabolic processGO:00160706.1RPS26, RPS7, RPL11, RPS24, RPL35A, RPS10
18translational initiationGO:00064136.1RPS7, RPL11, RPS14, RPL5, RPS19, RPS17
19translationGO:00064126.1RPL11, RPS24, RPL35A, RPS10, RPS17, RPS19
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:00001846.1RPS17, RPL11, RPS24, RPL35A, RPS10, RPS19
21translational elongationGO:00064146.1RPS24, RPL35A, RPS10, RPS17, RPS19, RPL5
22cellular protein metabolic processGO:00442676.1RPS24, RPS19, RPS7, RPS26, RPS14, RPL11
23viral processGO:00160326.1RPS24, RPS19, RPL11, RPL5, RPS14, RPS7
24gene expressionGO:00104676.1RPS10, RPS26, RPS7, RPS14, RPL5, RPS19

Molecular functions related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:00037238.6RPL11, RPL5, RPS14, RPS7
2structural constituent of ribosomeGO:00037356.2RPL11, RPS26, RPS7, RPS14, RPL5, RPS19
3poly(A) RNA bindingGO:00448225.5RPS26, RPS7, RPS14, RPL5, RPS19, RPS17

Sources for Macrocytic Anemia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet