MCID: MCR017
MIFTS: 44

Macrocytic Anemia malady

Summaries for Macrocytic Anemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 The term macrocytic is from Greek words meaning \"large cell\". A macrocytic class of anemia is an... more...

MalaCards: Macrocytic Anemia, also known as anemia macrocytic, is related to deficiency anemia and megaloblastic anemia. An important gene associated with Macrocytic Anemia is TCN2 (transcobalamin II), and among its related pathways are Heme Biosynthesis and Cobalamin (Cbl, vitamin B12) transport and metabolism. The compounds hydroxymethylbilane and uroporphyrinogen-iii have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and bone.

Aliases & Classifications for Macrocytic Anemia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

macrocytic anemia 8
anemia macrocytic 8 44
macrocytic anaemia of unspecified cause 8
macrocytic anemia of unspecified cause 8
anemia, macrocytic 60


External Ids:

Disease Ontology8 DOID:2361
NCIt39 C34381
MeSH34 D000748

Related Diseases for Macrocytic Anemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Macrocytic Anemia:



Diseases related to macrocytic anemia

Clinical Features for Macrocytic Anemia

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Drugs & Therapeutics for Macrocytic Anemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Macrocytic Anemia

Drug clinical trials:

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Search NIH Clinical Center for Macrocytic Anemia

Search CenterWatch for Macrocytic Anemia

Genetic Tests for Macrocytic Anemia

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Anatomical Context for Macrocytic Anemia

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32MalaCards
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MalaCards organs/tissues related to Macrocytic Anemia:

32
Liver, Small intestine, Bone, Bone marrow, Testes

Animal Models for Macrocytic Anemia or affiliated genes

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Publications for Macrocytic Anemia

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50PubMed
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Articles related to Macrocytic Anemia:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Differential diagnoses of macrocytic anemia, reticulocytosis and low serum haptoglobin in patients with myelodysplastic syndromes/acute leukemia: comment on "two cases of acute erythroid leukemia presenting with marked macrocytic anemia, reticulocytosis and hemolysis". (24390535)
2014
2
Spontaneous resolution of macrocytic anemia: old disease revisited. (22915983)
2012
3
Case 40. Misdiagnosis of refractory macrocytic anemia. (19021064)
2008
4
Intractable epilepsy as the presentation of vitamin B deficiency in the absence of macrocytic anemia. (16026570)
2005
5
Life-threatening maternal and fetal macrocytic anemia from antiretroviral therapy. (16260567)
2005
6
Macrocytic anemia during low-dose cisplatin and 5-Fluorouracil through implanted infusion port for unresectable hepatobilliary malignancies. (15865072)
2005
7
Apoptosis of late-stage erythroblasts in megaloblastic anemia: association with DNA damage and macrocyte production. (9192787)
1997
8
Simultaneous measurement of reticulocyte and red blood cell indices in healthy subjects and patients with microcytic and macrocytic anemia. (7833482)
1995
9
Partial amelioration of AZT-induced macrocytic anemia in the mouse by folic acid. (8241950)
1993
10
Clinching the diagnosis: macrocytic anemia. (3241737)
1988
11
Macrocytic anemia. (3821094)
1987
12
A cobalamin metabolic defect with homocystinuria, methylmalonic aciduria and macrocytic anemia. (2873525)
1986
13
Macrocytic-megaloblastic anemia in male NIH Swiss mice following repeated exposure to 1,3-butadiene. (3020740)
1986
14
Macrocytic-megaloblastic anemia in male B6C3F1 mice following chronic exposure to 1,3-butadiene. (3952753)
1986
15
Gametic and pleiotropic defects in mouse fetuses with Hertwig's macrocytic anemia. (4018402)
1985
16
Experimental production of possible autoimmune castritis followed by macrocytic anemia in athymic nude mice. (7374103)
1980
17
Vitamin E-responsive macrocytic anemia in protein-calorie malnutrition. Measurements of vitamin E, folic acid, vitamin C, vitamin B12 and iron. (5006442)
1966
18
MACROCYTIC HYPOCHROMIC ANEMIA. ITS MANIFESTATIONS IN CHILDREN IN THE TROPICS. (14173913)
1964
19
RESPONSE OF MACROCYTIC ANEMIA IN CHILDREN TO THE COENZYME Q4-CHROMANOL. (14061588)
1963
20
Cases from the Medical Grand Rounds, Massachusetts General Hospital. Case 501: macrocytic anemia of pregnancy. (14447560)
1961
21
Macrocytic anemia in aged. II. Blood & bone marrow changes in 65 elderly anemia patients]. (13613532)
1958
22
Diverticulosis of the small intestine and macrocytic anemia with report of two cases and studies on absorption of radioactive vitamin B12. (13501356)
1958
23
NUTRITIONAL macrocytic anemia. (14371208)
1955
24
Absorption of radioactive vitamin B12 after total gastrectomy; relation to macrocytic anemia and to the site of origin of Castle's intrinsic factor. (13185389)
1954
25
Absorption of radioactive vitamin B12 in patients with disease of the small intestine: relation to macrocytic anemia. (13256573)
1954
26
TREATMENT of nutritional macrocytic anemia. (13214638)
1954
27
Macrocytic anemia and leucocytosis of guinea pigs with muscular stiffness disease. (13167115)
1954
28
Hyperleukocytosis and macrocytic anemia resulting from carcinoma of the ileum; case report. (13109386)
1953
29
Experimental production of nutritional macrocytic anemia in swine. V. Hematologic manifestations of a combined deficiency of vitamin B12 and pteroylglutamic acid. (12977830)
1952
30
A case history presenting an interesting macrocytic anemia of unknown etiology. (12988144)
1952
31
Macrocytic anemia and its relation to liver biopsy of nutritional dystrophy in children. I. (13005513)
1952
32
Interrelationship of folic acid and vitamin B12 in macrocytic anemia associated with linitis plastica. (14932803)
1952
33
The diagnosis and treatment of macrocytic anemia. (14806798)
1951
34
Oral administration of vitamin B12 concentrate in tropical sprue and nutritional macrocytic anemia. (14902307)
1951
35
Observations on the macrocytic anemia associated with pregnancy. (18131962)
1949
36
Macrocytic anemia of pregnancy refractory to vitamin B12 therapy; response to treatment with folic acid; report of case. (18115522)
1949
37
Experimental production of a nutritional macrocytic anemia in swine. (18116110)
1949
38
The clinical association of macrocytic anemia with intestinal stricture and anastomosis. (18150156)
1949
39
Pernicious anemia, nutritional macrocytic anemia, and tropical sprue. (18920890)
1948
40
Macrocytic anemia of pregnancy; review of literature and report of a case treated with folic acid. (18105406)
1948
41
Vitamin B12 in pernicious anemia and puerperal macrocytic anemia. (18890061)
1948
42
Effect of Cholinesterase-containing Globulin Fraction of Human Plasma in Macrocytic Anemia. (17791762)
1948
43
Metabolic function of pteroylglutamic acid and its hexaglutamyl conjugate; hematologic and urinary excretion studies on patients with macrocytic anemia. (20279937)
1947
44
The treatment of macrocytic anemia. (20287069)
1947
45
Effect of folic acid on persons with macrocytic anemia in relapse. (21012836)
1946
46
Nutritional macrocytic anemia, especially in pregnancy; response to a substance in liver other than that effective in pernicious anemia. (21026488)
1946
47
EDEMA during induced remissions in macrocytic anemia. (21022323)
1946
48
Observations on the utilization of folic acid (vitamin BC) and vitamin BC conjugate by persons with pernicious anemia and macrocytic anemia following gastrectomy. (21026038)
1946
49
Macrocytic anemia treated with folic acid. (20986626)
1946
50
SPONTANEOUS RECOVERY FROM NUTRITIONAL MACROCYTIC ANEMIA IN YOUNG SWINE FOLLOWING INITIAL ESTRUS. (16694844)
1941

Genetic Variations for Macrocytic Anemia

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Expression for genes affiliated with Macrocytic Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macrocytic Anemia

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Pathways for genes affiliated with Macrocytic Anemia

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37NCBI BioSystems Database, 53Reactome, 29KEGG
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Pathways related to Macrocytic Anemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0FECH, UROD
29.6TCN2, MTR
3
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9.6TCN2, MTR
4
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7.5RPS26, RPS19, RPS14, RPS7, RPS17, RPS10
5
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6.4RPS7, RPS14, RPS19, RPS26, RPL5, RPS17
6
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6.4RPS26, RPS19, RPS14, RPS7, RPL5, RPS17
7
Hide members
6.4RPS14, RPS19, RPS26, RPS7, RPL5, RPS17
86.4RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
9
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6.4RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5

Compounds for genes affiliated with Macrocytic Anemia

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Macrocytic Anemia according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1hydroxymethylbilane44 2411.3UROD, FECH
2uroporphyrinogen-iii4410.3FECH, UROD
3protoporphyrinogen4410.3FECH, UROD
4pyrrole4410.2UROD, FECH
5formyl-coa44 2411.2UROD, FECH
6porphyrin4410.2FECH, UROD
7porphobilinogen44 11 2412.1FECH, UROD
85-aminolevulinic acid44 2411.0UROD, FECH
9corrinoid4410.0TCN2, MTR
10adenosylcobalamin44 2410.9MTR, TCN2
11methylcobalamin44 2410.9TCN2, MTR
12protoporphyrin ix44 11 2411.9FECH, UROD
13cyanocobalamin49 11 2411.9MTR, TCN2
14hydroxocobalamin44 1110.9MTR, TCN2
15cystathionine449.8TCN2, MTR
16vitamin b6449.7TCN2, MTR, FECH
17methylmalonic acid44 2410.7MTR, TCN2
18haem449.7UROD, FECH
19cobalamin44 2410.6TCN2, MTR
20rrna449.6RPS19, RPL5, RPL11

GO Terms for genes affiliated with Macrocytic Anemia

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16Gene Ontology
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Cellular components related to Macrocytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small ribosomal subunitGO:0159359.7RPS24, RPS26
2cytosolic large ribosomal subunitGO:0226259.1RPL35A, RPL11, RPL5
3ribosomeGO:0058409.1RPS19, RPS7, RPS17, RPS10
4cytosolic small ribosomal subunitGO:0226277.6RPS24, RPS26, RPS19, RPS14, RPS7, RPS17
5nucleolusGO:0057306.9RPS19, RPS14, RPS7, RPL5, RPL11, RPS10
6cytosolGO:0058295.6RPS26, RPS19, RPS14, RPS7, RPL5, RPS17

Biological processes related to Macrocytic Anemia according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1heme biosynthetic processGO:00678310.0UROD, FECH
2porphyrin-containing compound metabolic processGO:0067789.9UROD, FECH
3erythrocyte homeostasisGO:0341019.7RPS17, RPS24
4ribosomal large subunit biogenesisGO:0422739.6RPL35A, RPL11, RPL5
5maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)GO:0004629.6RPS24, RPS19
6cobalamin metabolic processGO:0092359.3TCN2, MTR
7maturation of SSU-rRNAGO:0304909.3RPS14, RPS19
8ribosomal small subunit assemblyGO:0000289.1RPS17, RPS14, RPS19
9ribosomal small subunit biogenesisGO:0422749.1RPS19, RPS7, RPS17, RPS24
10erythrocyte differentiationGO:0302189.1RPS19, RPS14, FECH
11rRNA processingGO:0063648.1RPS19, RPS7, RPL5, RPS17, RPL11, RPL35A
12SRP-dependent cotranslational protein targeting to membraneGO:0066146.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
13RNA metabolic processGO:0160706.7RPS17, RPL5, RPS7, RPS14, RPS19, RPS26
14mRNA metabolic processGO:0160716.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
15viral life cycleGO:0190586.7RPS26, RPS19, RPS14, RPS7, RPS24, RPS10
16viral transcriptionGO:0190836.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:0001846.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
18translationGO:0064126.7RPS17, RPL5, RPS7, RPS14, RPS19, RPS26
19translational initiationGO:0064136.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
20translational elongationGO:0064146.7RPS26, RPS19, RPS14, RPS24, RPS10, RPL35A
21translational terminationGO:0064156.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
22viral processGO:0160326.7RPS7, RPS14, RPS19, RPS26, RPL5, RPS17
23cellular protein metabolic processGO:0442676.6RPS7, RPS14, RPS19, RPS26, RPL5, RPS17
24gene expressionGO:0104676.6RPS26, RPS19, RPS14, RPS7, RPL5, RPS17

Molecular functions related to Macrocytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cobalamin bindingGO:0314199.6TCN2, MTR
2structural constituent of ribosomeGO:0037356.4RPS24, RPS26, RPS19, RPS14, RPS7, RPL5

Products for genes affiliated with Macrocytic Anemia

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Sources for Macrocytic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet