Macrocytic Anemia malady

Wikipedia: Macrocytic is from Greek words meaning \"large cell\". A macrocytic class of anemia is an anemia...⁴⁴ more...

MalaCards: Macrocytic Anemia, also known as anemia macrocytic, is related to diamond-blackfan anemia and aplastic anemia. An important gene associated with Macrocytic Anemia is TCN2 (transcobalamin II), and among its related pathways are Metabolism of RNA and Metabolism of mRNA. The drugs nandrolone and oxymetholone and the compounds corrinoid and adenosylcobalamin have been mentioned in the context of this disorder.

Aliases & Descriptions:

macrocytic anemia 6 7 8 anemia macrocytic 6 32 macrocytic anemia of unspecified cause (disorder) 6 macrocytic anaemia of unspecified cause 6

macrocytic anemia (disorder) 6 anemia, macrocytic 43 anemia 43

Diseases related to macrocytic anemia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 487)

id	Related Disease	Score	Top Affiliating Genes
1	diamond-blackfan anemia	34.8	RPL5, RPL11
2	aplastic anemia	34.0	RPL11, RPS19, RPL5, RPS24, RPS17, RPL35A
3	thiamine-responsive megaloblastic anemia syndrome	32.7	TCN2, MTR
4	congenital porphyria	27.2	FECH, UROD
5	vitamin b12 deficiency	26.9	MTR, TCN2
6	klippel-feil syndrome	26.9	RPS26P6, RPS26
7	cartilage-hair hypoplasia	24.6	RPS14, RPS19
8	malaria	24.2	TCN2, RPL11, RPS19, RPS10, RPL5, RPS7
9	anemia	23.4	TCN2, RPL11, RPS19, RPS10, RPL5, RPS7
10	short stature	22.6	RPL11, RPS19, RPS10, RPL5, RPS7, RPS24
11	cleft palate	21.5	TCN2, RPL11, RPS19, RPS10, RPL5, RPS7
12	methylmalonic acidemia with homocystinuria	13.1	MTR, TCN2
13	cblf	13.1	TCN2, MTR
14	methylmalonic aciduria and homocystinuria	13.0	TCN2, MTR
15	homocysteine plasma level	12.9	TCN2, MTR
16	variegate porphyria	12.7	UROD, FECH
17	glucose intolerance	12.7	MTR, TCN2
18	coproporphyria	12.7	UROD, FECH
19	acute hepatic porphyria	12.7	UROD, FECH
20	acute porphyria	12.7	FECH, UROD
21	neural tube defect	12.6	TCN2, MTR
22	acute intermittent porphyria	12.6	FECH, UROD
23	methylmalonic acidemia	12.4	MTR, TCN2
24	treacher collins syndrome	12.4	RPL11, RPL5, RPL35A, RPS14
25	fanconi's anemia	11.8
26	mayer-rokitansky-kuster-hauser syndrome	11.8	TCN2, FECH, MTR, UROD
27	hemolytic anemia	11.1
28	pierre robin sequence	10.2	RPL11, RPS19, RPS10, RPL5, RPS7, RPS24
29	sickle cell anemia	10.1
30	iron deficiency anemia	9.8
31	sideroblastic anemia	9.7
32	x-linked sideroblastic anemia	9.6
33	myelodysplastic syndrome	9.4
34	autoimmune hemolytic anemia	9.3
35	anemia of prematurity	9.0
36	congenital dyserythropoietic anemia	8.9
37	megaloblastic anemia	8.8
38	hepatitis	8.7
39	dyserythropoietic anemia	8.5
40	arthritis	8.5
41	leukemia	8.5
42	thalassemia	8.4
43	rheumatoid arthritis	8.3
44	pernicious anemia	8.3
45	kidney disease	8.2
46	beta thalassemia	8.1
47	pyruvate kinase deficiency	8.0
48	myeloma	8.0
49	paroxysmal nocturnal hemoglobinuria	8.0
50	microcytic anemia	7.9

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 darbepoetin alfa,recombinant, epoetin alfa,recombinant, nandrolone, nandrolone decanoate, nandrolone phenpropionate, oxymetholone, sodium ascorbate

Articles related to macrocytic anemia:

id	Title	Authors	Year	Affiliating Genes
1	A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. (19966810)	Barlow J.L.... McKenzie A.N.	2010	RPS14
2	Macrocytic anemia with anisocytosis due to alcohol abuse and vitamin B6 deficiency (9866426)	Iwama H.... Toyama K.	1998	FECH, UROD

Genes related to macrocytic anemia according to GeneCards:

(show all 17)

id	Symbol	Description	Score	GeneCards Section Context
1	TCN2	transcobalamin II	11.1	Aliases & Descriptions
2	RPS14	ribosomal protein S14	11.0	Publications
3	RPS26P6	ribosomal protein S26 pseudogene 6	11.0	Disorders
4	CDAN1	codanin 1	11.0
5	RPS17	ribosomal protein S17	11.0
6	RPL35A	ribosomal protein L35a	11.0
7	RPS26	ribosomal protein S26	11.0
8	RPS10	ribosomal protein S10	11.0
9	C5orf62	chromosome 5 open reading frame 62	11.0	Disorders
10	UROD	uroporphyrinogen decarboxylase	11.0	Publications
11	RPS7	ribosomal protein S7	11.0
12	RPS24	ribosomal protein S24	11.0
13	RPL11	ribosomal protein L11	11.0
14	RPL5	ribosomal protein L5	11.0
15	FECH	ferrochelatase	11.0	Publications
16	RPS19	ribosomal protein S19	11.0
17	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	11.0

Pathways related to macrocytic anemia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Metabolism of RNA38	9.2	RPL35A, RPL5, RPL11
2	Metabolism of mRNA38	7.5	RPS19, RPS10, RPS7, RPS24, RPS17, RPS14
3	CFTR translational fidelity (class I mutations)41	6.6	RPS26, RPL11, RPS14, RPL35A, RPS17, RPS24
4	Ribosome20	6.5	RPL35A, RPS17, RPS24, RPS7, RPL5, RPS10

Compounds related to macrocytic anemia according to GeneDecks:

(show all 19)

id	Compound	Score	Top Affiliating Genes
1	corrinoid32	10.1	MTR, TCN2
2	adenosylcobalamin32 18	11.0	TCN2, MTR
3	methylcobalamin32 18	11.0	MTR, TCN2
4	cyanocobalamin34 9 18 9	13.0	TCN2, MTR
5	hydroxocobalamin32 9 9	12.0	TCN2, MTR
6	cystathionine32	9.9	MTR, TCN2
7	hydroxymethylbilane32 18	10.8	UROD, FECH
8	methylmalonic acid32 18	10.8	TCN2, MTR
9	protoporphyrinogen32	9.8	FECH, UROD
10	uroporphyrinogen-iii32	9.8	FECH, UROD
11	pyrrole32	9.7	UROD, FECH
12	formyl-coa32 18	10.7	UROD, FECH
13	porphyrin32	9.7	FECH, UROD
14	cobalamin32 18	10.6	MTR, TCN2
15	porphobilinogen32 9 18 9	12.5	FECH, UROD
16	haem32	9.5	UROD, FECH
17	vitamin b632	9.4	MTR, FECH, TCN2
18	protoporphyrin ix32 9 18 9	12.2	UROD, FECH
19	rrna32	9.0	RPL11, RPS19, RPL5

Cellular components related to macrocytic anemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	small ribosomal subunit	GO:015935	9.8	RPS26, RPS24
2	ribosome	GO:005840	9.4	RPS10, RPS7, RPS17
3	cytosolic large ribosomal subunit	GO:022625	9.2	RPL35A, RPL5, RPL11
4	cytosolic small ribosomal subunit	GO:022627	7.9	RPS26, RPS19, RPS10, RPS7, RPS24, RPS17
5	nucleolus	GO:005730	7.1	RPL11, RPS19, RPS10, RPL5, RPS7, RPS14
6	cytosol	GO:005829	5.8	RPL11, RPS19, RPS10, RPL5, RPS7, RPS24

Biological processes related to macrocytic anemia according to GeneDecks:

(show all 21)

id	Name	GO ID	Score	Top Affiliating Genes
1	ribosomal small subunit assembly	GO:000028	10.0	RPS17, RPS14
2	erythrocyte homeostasis	GO:034101	9.7	RPS17, RPS24
3	heme biosynthetic process	GO:006783	9.5	UROD, FECH
4	ribosomal large subunit biogenesis	GO:042273	9.3	RPL35A, RPL5, RPL11
5	porphyrin-containing compound metabolic process	GO:006778	9.2	UROD, FECH
6	erythrocyte differentiation	GO:030218	8.9	FECH, RPS14, RPS19
7	ribosomal small subunit biogenesis	GO:042274	8.8	RPS19, RPS7, RPS24, RPS17
8	rRNA processing	GO:006364	7.6	RPL11, RPS19, RPL5, RPS7, RPS24, RPS17
9	viral transcription	GO:019083	6.9	RPL11, RPS14, RPL35A, RPS17, RPS24, RPS7
10	mRNA metabolic process	GO:016071	6.9	RPS14, RPL35A, RPS17, RPS24, RPS7, RPL5
11	SRP-dependent cotranslational protein targeting to membrane	GO:006614	6.9	RPL11, RPS14, RPL35A, RPS17, RPS24, RPS7
12	viral infectious cycle	GO:019058	6.9	RPS26, RPL11, RPS14, RPL35A, RPS17, RPS24
13	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO:000184	6.9	RPS26, RPL11, RPS14, RPL35A, RPS17, RPS24
14	translational initiation	GO:006413	6.9	RPS14, RPL35A, RPS17, RPS24, RPS7, RPL5
15	translational elongation	GO:006414	6.9	RPS26, RPL11, RPS14, RPL35A, RPS17, RPS24
16	translational termination	GO:006415	6.8	RPL35A, RPS17, RPS24, RPS7, RPL5, RPS10
17	RNA metabolic process	GO:016070	6.8	RPS14, RPL35A, RPS17, RPS24, RPS7, RPL5
18	translation	GO:006412	6.8	RPL11, RPS26, RPS14, RPL35A, RPS17, RPS24
19	viral reproduction	GO:016032	6.8	RPL11, RPS19, RPS10, RPL5, RPS7, RPS24
20	cellular protein metabolic process	GO:044267	6.8	RPL5, RPS10, RPS19, RPL11, RPS7, RPS24
21	gene expression	GO:010467	6.7	RPL11, RPS19, RPS10, RPL5, RPS7, RPS24

Molecular functions related to macrocytic anemia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cobalamin binding	GO:031419	9.4	TCN2, MTR
2	RNA binding	GO:003723	8.1	RPS14, RPS7, RPL5, RPS19, RPL11
3	structural constituent of ribosome	GO:003735	6.8	RPS26, RPL11, RPS19, RPL5, RPS7, RPS24