MCID: MCR017
MIFTS: 39

Macrocytic Anemia malady

Blood diseases category

Aliases & Classifications for Macrocytic Anemia

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Sources:
10Disease Ontology, 47Novoseek, 65UMLS, 36MeSH, 59SNOMED-CT, 42NCIt
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Aliases & Descriptions for Macrocytic Anemia:

Name: Macrocytic Anemia 10
Anemia, Macrocytic 65 36
Anemia Macrocytic 10 47
 
Macrocytic Anaemia of Unspecified Cause 10
Macrocytic Anemia of Unspecified Cause 10


Classifications:



External Ids:

Disease Ontology10 DOID:2361
NCIt42 C34381
MeSH36 D000748

Summaries for Macrocytic Anemia

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Wikipedia:68 The term macrocytic is from Greek words meaning \"large cell\". A macrocytic class of anemia is an... more...

MalaCards based summary: Macrocytic Anemia, also known as anemia, macrocytic, is related to pernicious anemia and macrocytic anemia, refractory, due to 5q deletion, somatic. An important gene associated with Macrocytic Anemia is SFXN4 (Sideroflexin 4), and among its related pathways are Vitamin digestion and absorption and Defective AMN causes hereditary megaloblastic anemia 1. Affiliated tissues include bone, liver and small intestine.

Related Diseases for Macrocytic Anemia

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Diseases related to Macrocytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1pernicious anemia30.6AMN, CUBN, TCN2
2macrocytic anemia, refractory, due to 5q deletion, somatic10.6
3diamond-blackfan anemia 710.4
4diamond-blackfan anemia 610.4
5diamond-blackfan anemia 810.4
6diamond-blackfan anemia 1210.4
7diamond-blackfan anemia 510.4
8diamond-blackfan anemia 310.4
9combined oxidative phosphorylation deficiency 1810.4
10diamond-blackfan anemia 1010.4
11diamond-blackfan anemia 410.4
12acute erythroid leukemia10.4
13leukemia10.4
14thrombocytosis10.4
15tropical sprue10.4
16thiamine-responsive megaloblastic anemia syndrome10.3
17myelodysplastic syndrome10.3
18diamond-blackfan anemia 910.3
19shwachman-diamond syndrome10.3
20dyserythropoietic anemia, congenital, type ib10.3
21diamond-blackfan anemia 1110.3
22diamond blackfan anemia 15 with mandibulofacial dysostosis10.3
23diamond-blackfan anemia 110.3
24diamond-blackfan anemia 14 with mandibulofacial dysostosis10.3
25dyserythropoietic anemia, congenital, type ia10.3
26acute leukemia10.3
27diamond-blackfan anemia10.3
28thrombocytopenia10.3
29megaloblastic anemia10.3
30steatorrhea10.3
31glossitis10.3
3216q24.3 microdeletion syndrome10.3
33rheumatoid arthritis10.1
34malaria10.1
35infantile liver failure syndrome 110.1
36celiac disease10.1
37diamond-blackfan anemia 210.1
38cartilage-hair hypoplasia10.1
39multiple myeloma10.1
40diamond-blackfan anemia 1310.1
41chromosome 15q25 deletion syndrome10.1
42transcobalamin ii deficiency10.1
43anemia, x-linked, with/without neutropenia and/or platelet abnormalities10.1
44anemia, sideroblastic, x-linked10.1
45dyserythropoietic anemia, congenital, type iii10.1
46alcohol abuse10.1
47arthritis10.1
48bipolar disorder10.1
49hepatitis10.1
50ischemic optic neuropathy10.1

Graphical network of the top 20 diseases related to Macrocytic Anemia:



Diseases related to macrocytic anemia

Symptoms for Macrocytic Anemia

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Drugs & Therapeutics for Macrocytic Anemia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Congenital Transmission of Lineages I and II of Trypanosoma CruziCompletedNCT01787968

Search NIH Clinical Center for Macrocytic Anemia


Cochrane evidence based reviews: Anemia, Macrocytic

Genetic Tests for Macrocytic Anemia

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Anatomical Context for Macrocytic Anemia

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MalaCards organs/tissues related to Macrocytic Anemia:

33
Bone, Liver, Small intestine, Bone marrow, Neutrophil, Testes

Animal Models for Macrocytic Anemia or affiliated genes

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MGI Mouse Phenotypes related to Macrocytic Anemia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Macrocytic Anemia

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Articles related to Macrocytic Anemia:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Macrocytic anemia and thrombocytopenia induced by orlistat. (24719628)
2013
2
Intractable epilepsy as the presentation of vitamin B deficiency in the absence of macrocytic anemia. (16026570)
2005
3
Life-threatening maternal and fetal macrocytic anemia from antiretroviral therapy. (16260567)
2005
4
87-year-old man with macrocytic anemia. (11213309)
2001
5
Macrocytic anemia and thrombocytosis associated with thymoma: a case report. (10602167)
2000
6
Dose-related thrombocytopenia and macrocytic anemia associated with valproate use in bipolar disorder. (9108818)
1997
7
Vitamin supplements improve the fertility potential of a subfertile male with macrocytic anemia--a case study. (7795372)
1994
8
Partial amelioration of AZT-induced macrocytic anemia in the mouse by folic acid. (8241950)
1993
9
A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. (1578958)
1992
10
Anterior ischemic optic neuropathy associated with macrocytic anemia. (2150841)
1990
11
Macrocytic anemia. (3821094)
1987
12
A cobalamin metabolic defect with homocystinuria, methylmalonic aciduria and macrocytic anemia. (2873525)
1986
13
Gametic and pleiotropic defects in mouse fetuses with Hertwig's macrocytic anemia. (4018402)
1985
14
Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes: the 5q-syndrome, a distinct entity. (453227)
1979
15
Cytochemical study of granulopoietic tissue. 3. Megaloblastic and macrocytic anemia. (5020392)
1972
16
Vitamin E-responsive macrocytic anemia in protein-calorie malnutrition. Measurements of vitamin E, folic acid, vitamin C, vitamin B12 and iron. (5006442)
1966
17
KWASHIORKOR IN EGYPT. II. HEMATOLOGIC ASPECTS (THE OCCURENCE OF A MACROCYTIC ANEMIA ASSOCIATED WITH LOW SERUM VITAMIN E AND A WIDE RANGE OF SERUM VITAMIN B12 LEVELS). (14322834)
1965
18
VITAMIN E RESPONSIVE MACROCYTIC ANEMIA. (14064339)
1963
19
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (14447714)
1961
20
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (13736665)
1961
21
Macrocytic anemia in aged. II. Blood & bone marrow changes in 65 elderly anemia patients]. (13613532)
1958
22
PITTING edema associated with nutritional macrocytic anemia. (14371228)
1955
23
Absorption of radioactive vitamin B12 after total gastrectomy; relation to macrocytic anemia and to the site of origin of Castle's intrinsic factor. (13185389)
1954
24
Macrocytic anemia associated with intestinal strictures and anastomoses: report of two cases. (13139137)
1954
25
Hypochromic and macrocytic anemia due to Anguillula intestinalis infestation, simulating saturnine anemia]. (13134861)
1953
26
Experimental production of nutritional macrocytic anemia in swine. V. Hematologic manifestations of a combined deficiency of vitamin B12 and pteroylglutamic acid. (12977830)
1952
27
A case history presenting an interesting macrocytic anemia of unknown etiology. (12988144)
1952
28
A case of macrocytic anemia in a dog. (14905888)
1952
29
Macrocytic anemia and Sato's bromsulfalein test in children with nutritional dystrophy. (13038764)
1952
30
FOLIC acid deficiency in macrocytic anemia of pregnancy and infancy. (14907394)
1952
31
Experimental anemias in the rat; I. Macrocytic anemia in chronic pteroylglutamic acid deficiency and after splenectomy in Bartonella muris infection. (15414205)
1950
32
Macrocytic anemia and impaired liver function in eczematous and certain other dermatoses. (14782693)
1950
33
Hemolytic macrocytic anemia. (15406291)
1950
34
Experimental production of a nutritional macrocytic anemia in swine. (15410775)
1950
35
Observations on the macrocytic anemia associated with pregnancy. (18131962)
1949
36
Macrocytic anemia of pregnancy refractory to vitamin B12 therapy; response to treatment with folic acid; report of case. (18115522)
1949
37
Neurologic sequelae in macrocytic anemia of gastrointestinal origin following folic acid therapy. (18889324)
1948
38
Macrocytic anemia; report of a case one month postpartum. (18857036)
1948
39
The effect of liver extract and vitamin B12 on the mucous membrane lesions of macrocytic anemia. (18877051)
1948
40
Pernicious anemia, nutritional macrocytic anemia, and tropical sprue. (18920890)
1948
41
Macrocytic anemia of pregnancy; review of literature and report of a case treated with folic acid. (18105406)
1948
42
Macrocytic anemia. (18858389)
1948
43
Vitamin B12 in pernicious anemia and puerperal macrocytic anemia. (18890061)
1948
44
Effect of Cholinesterase-containing Globulin Fraction of Human Plasma in Macrocytic Anemia. (17791762)
1948
45
Metabolic function of pteroylglutamic acid and its hexaglutamyl conjugate; hematologic and urinary excretion studies on patients with macrocytic anemia. (20279937)
1947
46
The effect of folic acid on the blood picture in human macrocytic anemia. (21064560)
1946
47
FOLIC acid in macrocytic anemia. (21027185)
1946
48
Further studies on folic acid in the treatment of macrocytic anemia. (21004150)
1945
49
SPONTANEOUS RECOVERY FROM NUTRITIONAL MACROCYTIC ANEMIA IN YOUNG SWINE FOLLOWING INITIAL ESTRUS. (16694844)
1941
50
COMPARISON OF HEMATOPOIESIS IN THE FETUS AND DURING RECOVERY FROM PERNICIOUS ANEMIA: TOGETHER WITH A CONSIDERATION OF THE RELATIONSHIP OF FETAL HEMATOPOIESIS TO MACROCYTIC ANEMIA OF PREGNANCY AND ANEMIA IN INFANTS. (16694355)
1935

Variations for Macrocytic Anemia

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Expression for genes affiliated with Macrocytic Anemia

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Search GEO for disease gene expression data for Macrocytic Anemia.

Pathways for genes affiliated with Macrocytic Anemia

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Pathways related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4CUBN, TCN2
2
Show member pathways
9.1AMN, CUBN
3
Show member pathways
8.9AMN, CUBN, TCN2
48.9AMN, CUBN, TCN2
5
Show member pathways
8.7RPS10, RPS17, RPS19, RPS24, RPS26, RPS28
6
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
7
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
8
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
9
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
10
Show member pathways
5.3AMN, CUBN, RPL11, RPL15, RPL26, RPL35A

GO Terms for genes affiliated with Macrocytic Anemia

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Cellular components related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1small ribosomal subunitGO:001593510.0RPS24, RPS26, RPS28
2focal adhesionGO:000592510.0RPL5, RPS10, RPS17, RPS19
3nucleolusGO:00057309.5RPL11, RPL5, RPS10, RPS19, RPS26
4cytosolic large ribosomal subunitGO:00226259.4RPL11, RPL15, RPL26, RPL35A, RPL5
5cytosolic small ribosomal subunitGO:00226279.4RPS10, RPS17, RPS19, RPS24, RPS26, RPS28
6ribosomeGO:00058407.6RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
7intracellularGO:00056227.3RPL11, RPL15, RPL26, RPL35A, RPL5, RPS17
8membraneGO:00160206.9CUBN, RPL11, RPL26, RPL35A, RPL5, RPS10
9cytosolGO:00058295.8CUBN, RPL11, RPL15, RPL26, RPL35A, RPL5
10extracellular exosomeGO:00700625.6AMN, CUBN, RPL11, RPL15, RPL26, RPL35A

Biological processes related to Macrocytic Anemia according to GeneCards Suite gene sharing:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1ribosomal large subunit assemblyGO:000002710.6RPL11, RPL5
2erythrocyte homeostasisGO:003410110.5RPS17, RPS24
3ribosomal small subunit assemblyGO:000002810.3RPS10, RPS17, RPS19
4maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)GO:000046210.1RPS19, RPS24, TSR2
5cytoplasmic translationGO:000218110.0RPL15, RPL26, RPL35A
6ribosomal small subunit biogenesisGO:00422749.9RPS17, RPS19, RPS24, RPS28
7ribosomal large subunit biogenesisGO:00422739.8RPL11, RPL26, RPL35A, RPL5
8lipoprotein metabolic processGO:00421579.7AMN, CUBN
9cobalamin transportGO:00158899.5AMN, CUBN, TCN2
10cobalamin metabolic processGO:00092359.4AMN, CUBN, TCN2
11vitamin metabolic processGO:00067669.1AMN, CUBN, TCN2
12water-soluble vitamin metabolic processGO:00067679.0AMN, CUBN, TCN2
13rRNA processingGO:00063648.4RPL11, RPL26, RPL35A, RPL5, RPS17, RPS19
14translational initiationGO:00064137.6RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
15translational terminationGO:00064157.6RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
16viral transcriptionGO:00190837.6RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
17translational elongationGO:00064147.5RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
18viral life cycleGO:00190587.4RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
19SRP-dependent cotranslational protein targeting to membraneGO:00066147.3RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:00001847.2RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
21viral processGO:00160327.2RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
22translationGO:00064127.0RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
23cellular protein metabolic processGO:00442676.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
24gene expressionGO:00104676.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10

Molecular functions related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cobalamin bindingGO:00314199.8CUBN, TCN2
2structural constituent of ribosomeGO:00037357.2RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
3poly(A) RNA bindingGO:00448226.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10

Sources for Macrocytic Anemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet