MCID: MCR017
MIFTS: 43

Macrocytic Anemia malady

Category: Blood diseases

Aliases & Classifications for Macrocytic Anemia

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Aliases & Descriptions for Macrocytic Anemia:

Name: Macrocytic Anemia 11 13
Anemia Macrocytic 11 25 48
Anemia, Macrocytic 37 66
 
Macrocytic Anaemia of Unspecified Cause 11
Macrocytic Anemia of Unspecified Cause 11

Classifications:



External Ids:

Disease Ontology11 DOID:2361
MeSH37 D000748
NCIt43 C34381

Summaries for Macrocytic Anemia

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Wikipedia:69 The term macrocytic is from Greek words meaning \"large cell\". A macrocytic class of anemia is an... more...

MalaCards based summary: Macrocytic Anemia, also known as anemia macrocytic, is related to macrocytic anemia, refractory, due to 5q deletion, somatic and megaloblastic anemia. An important gene associated with Macrocytic Anemia is SFXN4 (Sideroflexin 4), and among its related pathways are Vitamin digestion and absorption and Cobalamin (Cbl, vitamin B12) transport and metabolism. Affiliated tissues include liver, small intestine and bone marrow.

Related Diseases for Macrocytic Anemia

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Diseases related to Macrocytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1macrocytic anemia, refractory, due to 5q deletion, somatic12.3
2megaloblastic anemia10.5
3pernicious anemia10.3
4methylmalonic aciduria and homocystinuria type cblg10.1GIF, TCN2
5diamond-blackfan anemia 710.1
6diamond-blackfan anemia 610.1
7diamond-blackfan anemia 810.1
8diamond-blackfan anemia 1210.1
9diamond-blackfan anemia 510.1
10diamond-blackfan anemia 910.1
11diamond-blackfan anemia 310.1
12combined oxidative phosphorylation deficiency 1810.1
13diamond-blackfan anemia 1010.1
14diamond-blackfan anemia 410.1
15dyserythropoietic anemia, congenital, type ib10.1
16diamond-blackfan anemia 1110.1
17diamond-blackfan anemia 110.1
18dyserythropoietic anemia, congenital, type ia10.1
19myelodysplastic syndrome10.1
20acute erythroid leukemia10.1
21leukemia10.1
22tropical sprue10.1
23thrombocytosis10.1
24serine deficiency10.0GIF, TCN2
25acute leukemia10.0
26thrombocytopenia10.0
27steatorrhea10.0
28glossitis10.0
29diamond-blackfan anemia 210.0
30diamond-blackfan anemia 1310.0
31diamond blackfan anemia 15 with mandibulofacial dysostosis10.0
32diamond-blackfan anemia 14 with mandibulofacial dysostosis10.0
33microcytic anemia10.0
34rheumatoid arthritis9.8
35malaria9.8
36multiple myeloma9.8
37alcohol abuse9.8
38arthritis9.8
39bipolar disorder9.8
40diamond-blackfan anemia9.8
41hepatitis9.8
42ischemic optic neuropathy9.8
43liver disease9.8
44myeloma9.8
45pancytopenia9.8
46dementia9.8
47kwashiorkor9.8
48hypothyroidism9.8
49epilepsy9.8
50thymoma9.8

Graphical network of the top 20 diseases related to Macrocytic Anemia:



Diseases related to macrocytic anemia

Symptoms for Macrocytic Anemia

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Drugs & Therapeutics for Macrocytic Anemia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Congenital Transmission of Lineages I and II of Trypanosoma CruziCompletedNCT01787968

Search NIH Clinical Center for Macrocytic Anemia


Cochrane evidence based reviews: anemia, macrocytic

Genetic Tests for Macrocytic Anemia

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Genetic tests related to Macrocytic Anemia:

id Genetic test Affiliating Genes
1 Macrocytic Anemia25

Anatomical Context for Macrocytic Anemia

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MalaCards organs/tissues related to Macrocytic Anemia:

34
Liver, Small intestine, Bone marrow, Bone, Neutrophil, Testes

Animal Models for Macrocytic Anemia or affiliated genes

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Publications for Macrocytic Anemia

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Articles related to Macrocytic Anemia:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
A Japanese family with X-linked sideroblastic anemia affecting females and manifesting as macrocytic anemia. (26862056)
2016
2
Delayed globin synthesis leads to excess heme and the macrocytic anemia of Diamond Blackfan anemia and del(5q) myelodysplastic syndrome. (27169803)
2016
3
Prevalence of pernicious anemia in patients with macrocytic anemia and low serum B12. (25674111)
2014
4
Amisulpride-induced macrocytic anemia. (23487206)
2013
5
Coprophagia and pica in individuals with mild to moderate dementia and mixed (iron deficiency and macrocytic) anemia. (22188083)
2011
6
A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. (19966810)
2010
7
Life-threatening maternal and fetal macrocytic anemia from antiretroviral therapy. (16260567)
2005
8
Rapid evolution of multiple myeloma after cobalamin therapy for megaloblastic erythropoiesis with macrocytic anemia. (9619920)
1998
9
Macrocytic anemia. (8546042)
1996
10
Vitamin supplements improve the fertility potential of a subfertile male with macrocytic anemia--a case study. (7795372)
1994
11
A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. (1578958)
1992
12
Clinching the diagnosis: macrocytic anemia. (3241737)
1988
13
Macrocytic anemia. (3821094)
1987
14
Gametic and pleiotropic defects in mouse fetuses with Hertwig's macrocytic anemia. (4018402)
1985
15
Hypothyroidism causing macrocytic anemia unresponsive to B12 and folate. (6864824)
1983
16
Experimental production of possible autoimmune castritis followed by macrocytic anemia in athymic nude mice. (7374103)
1980
17
Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes: the 5q-syndrome, a distinct entity. (453227)
1979
18
KWASHIORKOR IN EGYPT. II. HEMATOLOGIC ASPECTS (THE OCCURENCE OF A MACROCYTIC ANEMIA ASSOCIATED WITH LOW SERUM VITAMIN E AND A WIDE RANGE OF SERUM VITAMIN B12 LEVELS). (14322834)
1965
19
Gastrointestinal lesions causing macrocytic anemia. (5826211)
1965
20
VITAMIN E RESPONSIVE MACROCYTIC ANEMIA. (14064339)
1963
21
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (14447714)
1961
22
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (13736665)
1961
23
Macrocytic anemia in aged. II. Blood & bone marrow changes in 65 elderly anemia patients]. (13613532)
1958
24
Severe nutritional macrocytic anemia in emotionally disturbed patients. (13520639)
1958
25
PITTING edema associated with nutritional macrocytic anemia. (14371228)
1955
26
RELATION between vitamin B12 and macrocytic anemia. (13211347)
1955
27
Absorption of radioactive vitamin B12 after total gastrectomy; relation to macrocytic anemia and to the site of origin of Castle's intrinsic factor. (13185389)
1954
28
Hypochromic and macrocytic anemia due to Anguillula intestinalis infestation, simulating saturnine anemia]. (13134861)
1953
29
Experimental production of nutritional macrocytic anemia in swine. V. Hematologic manifestations of a combined deficiency of vitamin B12 and pteroylglutamic acid. (12977830)
1952
30
Pernicious, macrocytic, anemia of pregnancy. (13011233)
1952
31
Interrelationship of folic acid and vitamin B12 in macrocytic anemia associated with linitis plastica. (14932803)
1952
32
The diagnosis and treatment of macrocytic anemia. (14806798)
1951
33
Quantitative analysis of the normal and four alternative degrees of an inherited macrocytic anemia in the house mouse. I. Number and size of erythrocytes. (14869351)
1951
34
Experimental production of a nutritional macrocytic anemia in swine. (15410775)
1950
35
Macrocytic anemia of pregnancy refractory to vitamin B12 therapy; response to treatment with folic acid; report of case. (18115522)
1949
36
The experimental production of macrocytic anemia by operations of the intestinal tract. (18150157)
1949
37
The clinical association of macrocytic anemia with intestinal stricture and anastomosis. (18150156)
1949
38
Pernicious anemia, nutritional macrocytic anemia, and tropical sprue. (18920890)
1948
39
Macrocytic anemia. (18858389)
1948
40
Vitamin B12 in pernicious anemia and puerperal macrocytic anemia. (18890061)
1948
41
Metabolic function of pteroylglutamic acid and its hexaglutamyl conjugate; hematologic and urinary excretion studies on patients with macrocytic anemia. (20279937)
1947
42
Absence of a Macrocytic Anemia in Dogs Fed Choline or Choline Plus Fat. (17788565)
1947
43
Effect of extrinsic factor, liver extract, and folic acid on induced macrocytic anemia of swine. (20272771)
1947
44
Synthetic folic acid; the effectiveness of a conjugated form in the treatment of tropical sprue, addisonian pernicious anemia and nutritional macrocytic anemia. (20293021)
1947
45
Treatment of macrocytic anemia with synthetic L. casei factor (folic acid). (20988877)
1946
46
The treatment of macrocytic anemia with Lactobacillus casei factor (pteroylglutamic acid). (20274104)
1946
47
PTERINS and macrocytic anemia factors. (20275442)
1946
48
The activity of another L. casei factor in macrocytic anemia. (20993247)
1946
49
Macrocytic Anemia in Liver Disease. (18746158)
1942
50
SPONTANEOUS RECOVERY FROM NUTRITIONAL MACROCYTIC ANEMIA IN YOUNG SWINE FOLLOWING INITIAL ESTRUS. (16694844)
1941

Variations for Macrocytic Anemia

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Expression for genes affiliated with Macrocytic Anemia

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Search GEO for disease gene expression data for Macrocytic Anemia.

Pathways for genes affiliated with Macrocytic Anemia

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Pathways related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.6GIF, TCN2
29.6GIF, TCN2
3
Show member pathways
7.4RPS10, RPS17, RPS19, RPS24, RPS26, RPS28
4
Show member pathways
5.8RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
5
Show member pathways
5.8RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
6
Show member pathways
5.8RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
7
Show member pathways
5.8RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
8
Show member pathways
5.8RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
9
Show member pathways
5.0GIF, RPL11, RPL15, RPL26, RPL35A, RPL5
10
Show member pathways
4.5ADH1B, GIF, RPL11, RPL15, RPL26, RPL35A

GO Terms for genes affiliated with Macrocytic Anemia

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Cellular components related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1small ribosomal subunitGO:00159359.8RPS24, RPS26, RPS28, RPS29
2cytosolic large ribosomal subunitGO:00226259.6RPL11, RPL15, RPL26, RPL35A, RPL5
3ribosomeGO:00058409.0RPL15, RPS10, RPS17, RPS19, RPS7
4extracellular matrixGO:00310128.9RPL11, RPL35A, RPS10, RPS17, RPS19, RPS7
5nucleolusGO:00057308.6RPL11, RPL5, RPS10, RPS19, RPS26, RPS7
6focal adhesionGO:00059258.6RPL5, RPS10, RPS17, RPS19, RPS29, RPS7
7cytosolic small ribosomal subunitGO:00226278.0RPS10, RPS17, RPS19, RPS24, RPS26, RPS28
8membraneGO:00160206.8RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
9extracellular exosomeGO:00700626.1RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
10cytosolGO:00058295.4ADH1B, RPL11, RPL15, RPL26, RPL35A, RPL5

Biological processes related to Macrocytic Anemia according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1erythrocyte homeostasisGO:003410110.4RPS17, RPS24
2ribosomal large subunit assemblyGO:000002710.4RPL11, RPL5
3ribosomal small subunit assemblyGO:000002810.3RPS10, RPS17, RPS19
4cobalt ion transportGO:000682410.2GIF, TCN2
5cytoplasmic translationGO:000218110.0RPL15, RPL26, RPL35A
6cobalamin metabolic processGO:000923510.0GIF, TCN2
7cobalamin transportGO:001588910.0GIF, TCN2
8maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)GO:00004629.8RPS19, RPS24, TSR2
9ribosomal large subunit biogenesisGO:00422739.8RPL11, RPL26, RPL35A, RPL5
10ribosomal small subunit biogenesisGO:00422749.0RPS17, RPS19, RPS24, RPS28, RPS7
11SRP-dependent cotranslational protein targeting to membraneGO:00066146.3RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
12viral transcriptionGO:00190836.3RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
13translationGO:00064126.1RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
14translational initiationGO:00064136.0RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:00001845.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
16rRNA processingGO:00063645.8RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10

Molecular functions related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cobalamin bindingGO:003141910.2GIF, TCN2
2RNA bindingGO:00037238.5RPL11, RPL15, RPL26, RPL5, RPS7
3poly(A) RNA bindingGO:00448226.3RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
4structural constituent of ribosomeGO:00037356.3RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10

Sources for Macrocytic Anemia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet