MCID: MCR017
MIFTS: 41

Macrocytic Anemia malady

Category: Blood diseases

Aliases & Classifications for Macrocytic Anemia

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Aliases & Descriptions for Macrocytic Anemia:

Name: Macrocytic Anemia 10 12
Anemia, Macrocytic 36 65
Anemia Macrocytic 10 47
 
Macrocytic Anaemia of Unspecified Cause 10
Macrocytic Anemia of Unspecified Cause 10

Classifications:



External Ids:

Disease Ontology10 DOID:2361
MeSH36 D000748
NCIt42 C34381
UMLS65 C0002886

Summaries for Macrocytic Anemia

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Wikipedia:68 The term macrocytic is from Greek words meaning \"large cell\". A macrocytic class of anemia is an... more...

MalaCards based summary: Macrocytic Anemia, also known as anemia, macrocytic, is related to macrocytic anemia, refractory, due to 5q deletion, somatic and megaloblastic anemia. An important gene associated with Macrocytic Anemia is SFXN4 (Sideroflexin 4), and among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Transport to the Golgi and subsequent modification. Affiliated tissues include b cells, heart and thyroid.

Related Diseases for Macrocytic Anemia

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Diseases related to Macrocytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1macrocytic anemia, refractory, due to 5q deletion, somatic12.3
2megaloblastic anemia10.5
3pernicious anemia10.3
4hypocalciuric hypercalcemia, familial, type iii10.1KITLG, RPS19
5diamond-blackfan anemia 710.1
6diamond-blackfan anemia 610.1
7diamond-blackfan anemia 810.1
8diamond-blackfan anemia 1210.1
9diamond-blackfan anemia 510.1
10diamond-blackfan anemia 910.1
11diamond-blackfan anemia 310.1
12combined oxidative phosphorylation deficiency 1810.1
13diamond-blackfan anemia 1010.1
14diamond-blackfan anemia 410.1
15dyserythropoietic anemia, congenital, type ib10.1
16diamond-blackfan anemia 1110.1
17diamond-blackfan anemia 110.1
18dyserythropoietic anemia, congenital, type ia10.1
19myelodysplastic syndrome10.1
20acute erythroid leukemia10.1
21leukemia10.1
22tropical sprue10.1
23thrombocytosis10.1
24acute leukemia10.0
25thrombocytopenia10.0
26steatorrhea10.0
27glossitis10.0
28diamond-blackfan anemia 210.0
29diamond-blackfan anemia 1310.0
30diamond blackfan anemia 15 with mandibulofacial dysostosis10.0
31diamond-blackfan anemia 14 with mandibulofacial dysostosis10.0
32microcytic anemia10.0
33rhabdoid tumor predisposition syndrome 29.9RPS26, TSR2
34rheumatoid arthritis9.8
35malaria9.8
36multiple myeloma9.8
37alcohol abuse9.8
38arthritis9.8
39bipolar disorder9.8
40diamond-blackfan anemia9.8
41hepatitis9.8
42ischemic optic neuropathy9.8
43liver disease9.8
44myeloma9.8
45pancytopenia9.8
46dementia9.8
47kwashiorkor9.8
48hypothyroidism9.8
49thymoma9.8
50linitis plastica9.8

Graphical network of the top 20 diseases related to Macrocytic Anemia:



Diseases related to macrocytic anemia

Symptoms for Macrocytic Anemia

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Drugs & Therapeutics for Macrocytic Anemia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Congenital Transmission of Lineages I and II of Trypanosoma CruziCompletedNCT01787968

Search NIH Clinical Center for Macrocytic Anemia


Cochrane evidence based reviews: anemia, macrocytic

Genetic Tests for Macrocytic Anemia

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Anatomical Context for Macrocytic Anemia

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MalaCards organs/tissues related to Macrocytic Anemia:

33
B cells, Heart, Thyroid, Breast, Endothelial, Prostate, Liver

Animal Models for Macrocytic Anemia or affiliated genes

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MGI Mouse Phenotypes related to Macrocytic Anemia:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Macrocytic Anemia

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Articles related to Macrocytic Anemia:

(show top 50)    (show all 135)
idTitleAuthorsYear
1
A Japanese family with X-linked sideroblastic anemia affecting females and manifesting as macrocytic anemia. (26862056)
2016
2
Macrocytic anemia and thrombocytopenia induced by orlistat. (24719628)
2013
3
Intractable epilepsy as the presentation of vitamin B deficiency in the absence of macrocytic anemia. (16026570)
2005
4
Life-threatening maternal and fetal macrocytic anemia from antiretroviral therapy. (16260567)
2005
5
87-year-old man with macrocytic anemia. (11213309)
2001
6
Macrocytic anemia and thrombocytosis associated with thymoma: a case report. (10602167)
2000
7
Dose-related thrombocytopenia and macrocytic anemia associated with valproate use in bipolar disorder. (9108818)
1997
8
Vitamin supplements improve the fertility potential of a subfertile male with macrocytic anemia--a case study. (7795372)
1994
9
Partial amelioration of AZT-induced macrocytic anemia in the mouse by folic acid. (8241950)
1993
10
A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. (1578958)
1992
11
Anterior ischemic optic neuropathy associated with macrocytic anemia. (2150841)
1990
12
Macrocytic anemia. (3821094)
1987
13
A cobalamin metabolic defect with homocystinuria, methylmalonic aciduria and macrocytic anemia. (2873525)
1986
14
Gametic and pleiotropic defects in mouse fetuses with Hertwig's macrocytic anemia. (4018402)
1985
15
Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes: the 5q-syndrome, a distinct entity. (453227)
1979
16
Cytochemical study of granulopoietic tissue. 3. Megaloblastic and macrocytic anemia. (5020392)
1972
17
KWASHIORKOR IN EGYPT. II. HEMATOLOGIC ASPECTS (THE OCCURENCE OF A MACROCYTIC ANEMIA ASSOCIATED WITH LOW SERUM VITAMIN E AND A WIDE RANGE OF SERUM VITAMIN B12 LEVELS). (14322834)
1965
18
VITAMIN E RESPONSIVE MACROCYTIC ANEMIA. (14064339)
1963
19
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (14447714)
1961
20
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (13736665)
1961
21
Macrocytic anemia in aged. II. Blood & bone marrow changes in 65 elderly anemia patients]. (13613532)
1958
22
PITTING edema associated with nutritional macrocytic anemia. (14371228)
1955
23
Absorption of radioactive vitamin B12 after total gastrectomy; relation to macrocytic anemia and to the site of origin of Castle's intrinsic factor. (13185389)
1954
24
Macrocytic anemia associated with intestinal strictures and anastomoses: report of two cases. (13139137)
1954
25
Hypochromic and macrocytic anemia due to Anguillula intestinalis infestation, simulating saturnine anemia]. (13134861)
1953
26
Experimental production of nutritional macrocytic anemia in swine. V. Hematologic manifestations of a combined deficiency of vitamin B12 and pteroylglutamic acid. (12977830)
1952
27
A case history presenting an interesting macrocytic anemia of unknown etiology. (12988144)
1952
28
A case of macrocytic anemia in a dog. (14905888)
1952
29
Macrocytic anemia and Sato's bromsulfalein test in children with nutritional dystrophy. (13038764)
1952
30
FOLIC acid deficiency in macrocytic anemia of pregnancy and infancy. (14907394)
1952
31
Experimental anemias in the rat; I. Macrocytic anemia in chronic pteroylglutamic acid deficiency and after splenectomy in Bartonella muris infection. (15414205)
1950
32
Macrocytic anemia and impaired liver function in eczematous and certain other dermatoses. (14782693)
1950
33
Hemolytic macrocytic anemia. (15406291)
1950
34
Experimental production of a nutritional macrocytic anemia in swine. (15410775)
1950
35
Observations on the macrocytic anemia associated with pregnancy. (18131962)
1949
36
Macrocytic anemia of pregnancy refractory to vitamin B12 therapy; response to treatment with folic acid; report of case. (18115522)
1949
37
Neurologic sequelae in macrocytic anemia of gastrointestinal origin following folic acid therapy. (18889324)
1948
38
Macrocytic anemia; report of a case one month postpartum. (18857036)
1948
39
The effect of liver extract and vitamin B12 on the mucous membrane lesions of macrocytic anemia. (18877051)
1948
40
Pernicious anemia, nutritional macrocytic anemia, and tropical sprue. (18920890)
1948
41
Macrocytic anemia of pregnancy; review of literature and report of a case treated with folic acid. (18105406)
1948
42
Macrocytic anemia. (18858389)
1948
43
Vitamin B12 in pernicious anemia and puerperal macrocytic anemia. (18890061)
1948
44
Effect of Cholinesterase-containing Globulin Fraction of Human Plasma in Macrocytic Anemia. (17791762)
1948
45
Metabolic function of pteroylglutamic acid and its hexaglutamyl conjugate; hematologic and urinary excretion studies on patients with macrocytic anemia. (20279937)
1947
46
The effect of folic acid on the blood picture in human macrocytic anemia. (21064560)
1946
47
FOLIC acid in macrocytic anemia. (21027185)
1946
48
Further studies on folic acid in the treatment of macrocytic anemia. (21004150)
1945
49
SPONTANEOUS RECOVERY FROM NUTRITIONAL MACROCYTIC ANEMIA IN YOUNG SWINE FOLLOWING INITIAL ESTRUS. (16694844)
1941
50
COMPARISON OF HEMATOPOIESIS IN THE FETUS AND DURING RECOVERY FROM PERNICIOUS ANEMIA: TOGETHER WITH A CONSIDERATION OF THE RELATIONSHIP OF FETAL HEMATOPOIESIS TO MACROCYTIC ANEMIA OF PREGNANCY AND ANEMIA IN INFANTS. (16694355)
1935

Variations for Macrocytic Anemia

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Expression for genes affiliated with Macrocytic Anemia

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Search GEO for disease gene expression data for Macrocytic Anemia.

Pathways for genes affiliated with Macrocytic Anemia

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Pathways related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.6RPS10, RPS17, RPS19, RPS24, RPS26, RPS7
2
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
3
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
4
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
5
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
6
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
7
Show member pathways
5.9KITLG, RPL11, RPL15, RPL26, RPL35A, RPL5
8
Show member pathways
5.5ADH1B, ALAS2, RPL11, RPL15, RPL26, RPL35A

GO Terms for genes affiliated with Macrocytic Anemia

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Cellular components related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1small ribosomal subunitGO:001593510.4RPS24, RPS26
2ribosomeGO:00058409.4RPL35A, RPS10, RPS19, RPS26, RPS7
3extracellular exosomeGO:00700628.9RPS10, RPS17, RPS19, RPS26, RPS7
4cytosolGO:00058298.5RPL15, RPL26, RPL35A, RPL5, RPS24, RPS7
5membraneGO:00160206.7RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10

Biological processes related to Macrocytic Anemia according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1translational elongationGO:000641410.2RPS10, RPS17, RPS19
2cytoplasmic translationGO:00021819.9RPL15, RPL26, RPL35A
3ribosomal small subunit biogenesisGO:00422749.6RPS17, RPS19, RPS24, RPS7
4erythrocyte differentiationGO:00302189.4ALAS2, RPS19
5gene expressionGO:00104679.1RPL11, RPL15, RPL26, RPL35A
6nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:00001849.1RPL11, RPL5, RPS10, RPS17, RPS19
7viral transcriptionGO:00190838.7RPL11, RPS10, RPS17, RPS19, RPS24, RPS26
8translational terminationGO:00064158.4RPL11, RPL15, RPL26, RPL35A, RPS10, RPS17
9SRP-dependent cotranslational protein targeting to membraneGO:00066147.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
10translational initiationGO:00064137.3RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
11viral life cycleGO:00190587.1RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
12viral processGO:00160327.1RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
13rRNA processingGO:00063646.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10

Sources for Macrocytic Anemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet