MCID: MCR017
MIFTS: 41

Macrocytic Anemia malady

Category: Blood diseases

Aliases & Classifications for Macrocytic Anemia

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Aliases & Descriptions for Macrocytic Anemia:

Name: Macrocytic Anemia 10 12
Anemia, Macrocytic 36 65
Anemia Macrocytic 10 47
 
Macrocytic Anaemia of Unspecified Cause 10
Macrocytic Anemia of Unspecified Cause 10

Classifications:



External Ids:

Disease Ontology10 DOID:2361
MeSH36 D000748
NCIt42 C34381
UMLS65 C0002886

Summaries for Macrocytic Anemia

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Wikipedia:68 The term macrocytic is from Greek words meaning \"large cell\". A macrocytic class of anemia is an... more...

MalaCards based summary: Macrocytic Anemia, also known as anemia, macrocytic, is related to macrocytic anemia, refractory, due to 5q deletion, somatic and diamond-blackfan anemia 7. An important gene associated with Macrocytic Anemia is SFXN4 (Sideroflexin 4), and among its related pathways are Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S and Transport to the Golgi and subsequent modification. Affiliated tissues include heart, testes and prostate.

Related Diseases for Macrocytic Anemia

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Diseases related to Macrocytic Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1macrocytic anemia, refractory, due to 5q deletion, somatic12.7
2diamond-blackfan anemia 710.5
3diamond-blackfan anemia 610.5
4diamond-blackfan anemia 810.5
5diamond-blackfan anemia 1210.5
6diamond-blackfan anemia 510.5
7diamond-blackfan anemia 910.5
8diamond-blackfan anemia 310.5
9combined oxidative phosphorylation deficiency 1810.5
10diamond-blackfan anemia 1010.5
11diamond-blackfan anemia 410.5
12dyserythropoietic anemia, congenital, type ib10.5
13diamond-blackfan anemia 1110.5
14diamond-blackfan anemia 110.5
15dyserythropoietic anemia, congenital, type ia10.5
16lymphoma10.5
17diamond-blackfan anemia 210.4
18diamond-blackfan anemia 1310.4
19diamond blackfan anemia 15 with mandibulofacial dysostosis10.4
20diamond-blackfan anemia 14 with mandibulofacial dysostosis10.4
21microcytic anemia10.4
22megaloblastic anemia10.4
23arthritis10.3
24leukemia10.3
25thyroiditis10.3
26rheumatoid arthritis10.2
27breast cancer10.2
28citrullinemia10.2
29pyruvate carboxylase deficiency10.2
30hepatitis10.2
31artery disease10.2
32lymphoblastic leukemia10.2
33thyroid cancer10.2
34adenocarcinoma10.2
35myelitis10.2
36pancreatitis10.2
37kidney disease10.2
38lupus erythematosus10.2
39castleman disease10.2
40hyperammonemia10.2
41endotheliitis10.2
42hypocalciuric hypercalcemia, familial, type iii10.1KITLG, RPS19
43pheochromocytoma10.1
44neuroblastoma10.1
45myocardial infarction10.1
46lung cancer10.1
47hiv-110.1
48hepatocellular carcinoma10.1
49coronary artery disease10.1
50hodgkin lymphoma10.1

Graphical network of the top 20 diseases related to Macrocytic Anemia:



Diseases related to macrocytic anemia

Symptoms for Macrocytic Anemia

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Drugs & Therapeutics for Macrocytic Anemia

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Interventional clinical trials:

idNameStatusNCT IDPhase
1Congenital Transmission of Lineages I and II of Trypanosoma CruziCompletedNCT01787968

Search NIH Clinical Center for Macrocytic Anemia


Cochrane evidence based reviews: anemia, macrocytic

Genetic Tests for Macrocytic Anemia

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Anatomical Context for Macrocytic Anemia

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MalaCards organs/tissues related to Macrocytic Anemia:

33
Heart, Testes, Prostate, Brain, Breast, Pituitary, Endothelial

Animal Models for Macrocytic Anemia or affiliated genes

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MGI Mouse Phenotypes related to Macrocytic Anemia:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Macrocytic Anemia

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Articles related to Macrocytic Anemia:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Survival after Heart Transplantation in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy. (27154489)
2016
2
Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats. (27010894)
2016
3
Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma. (25757065)
2015
4
The Features of Genetic Prion Diseases Based on Chinese Surveillance Program. (26488179)
2015
5
High prevalence of 'mitral valve prolapse syndrome' (MVPS) among older children and adolescents in a contained population. (23684344)
2013
6
Aesthetic and functional management of a patient with Cornelia de Lange syndrome. (22629076)
2012
7
Prevention of graft-versus-host disease. (23187772)
2012
8
Bilateral pneumothorax after orthognatic surgery. (23814593)
2012
9
A double-blind, randomized, controlled study of botulinum toxin type A in MS-related tremor. (22753445)
2012
10
Estrogen related receptor I+-induced adipogenesis is PGC-1I^-dependent. (21732060)
2012
11
Interleukin 28B genetic polymorphisms play a minor role in identifying optimal treatment duration in HCV genotype 1 slow responders to pegylated interferon plus ribavirin. (22898703)
2012
12
Curing all patients with acute promyelocytic leukemia: are we there yet? (22093584)
2011
13
Strengths and limitations of the six-minute-walk test: a model biomarker study in idiopathic pulmonary fibrosis. (21531951)
2011
14
Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. (19805114)
2009
15
CSF biomarkers in Alzheimer's disease and controls: associations with APOE genotype are modified by age. (19276554)
2009
16
A fatal case of invasive fungal sinusitis by Scopulariopsis acremonium in a bone marrow transplant recipient. (19386530)
2009
17
Gene symbol: CYP21A2. Disease: Non-classic 21-Hydroxylase deficiency. (20960659)
2008
18
Bisphosphonates, osteonecrosis, osteogenesis imperfecta and dental extractions: a case series. (18644240)
2008
19
The dexamethasone-suppressed corticotropin-releasing hormone stimulation test and the desmopressin test to distinguish Cushing's syndrome from pseudo-Cushing's states. (17581261)
2007
20
Nonsteroidal drugs for the treatment of noninfectious posterior and intermediate uveitis. (17435428)
2007
21
Artesunate, artemether or quinine in severe Plasmodium falciparum malaria? (17402835)
2007
22
Percutaneous sclerotherapy for lymphangioma and soft-tissue venous malformation located in the maxillofacial region in children and young adults. (24351228)
2006
23
Thromboxane A2 receptor-mediated G12/13-dependent glial morphological change. (16876780)
2006
24
Adenosine A2A receptors are up-regulated in Pick's disease frontal cortex. (17107593)
2006
25
Autoreactive T and B cells from bullous pemphigoid (BP) patients recognize epitopes clustered in distinct regions of BP180 and BP230. (16424234)
2006
26
Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist. (16202610)
2006
27
Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? (16216822)
2005
28
Male-to-male transmission of X-linked Alport syndrome in a boy with a 47,XXY karyotype. (15957001)
2005
29
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. (15650747)
2005
30
BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI. (14729964)
2004
31
Nitric oxide synthase gene transfer inhibits biological features of bypass graft disease in the human saphenous vein. (14752408)
2004
32
Metformin, but not thiazolidinediones, inhibits plasminogen activator inhibitor-1 production in human adipose tissue in vitro. (12669266)
2003
33
Familial inclusion body myositis: a report on two Japanese sisters. (14606722)
2003
34
Synthesis and pharmacological evaluation of novel non-lactone analogues of camptothecin. (12873503)
2003
35
Mutations in the fukutin-related protein gene (FKRP) identify limb girdle muscular dystrophy 2I as a milder allelic variant of congenital muscular dystrophy MDC1C. (11741828)
2001
36
Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. (11133773)
2001
37
Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. (11535811)
2001
38
The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly. (10965128)
2000
39
Ethnic differences in the expression of Epstein-Barr virus latent membrane protein-1 mutations in nasopharyngeal carcinoma. (11106799)
2000
40
Signaling by ABL oncogenes through cyclin D1. (7568169)
1995
41
Proton magnetic resonance spectroscopy studies in lactic acidosis and mitochondrial disorders. (8412023)
1993
42
Identification of two new LDL-receptor mutations causing homozygous familial hypercholesterolemia in a South African of Indian origin. (8347689)
1993
43
The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA. (1549122)
1992
44
The neuronal substrate of integration in the oculomotor system. (1410443)
1992
45
Effect of GR32191 and other thromboxane receptor blocking drugs on human platelet deposition onto de-endothelialized arteries. (1386166)
1992
46
Sex-determining region Y (SRY) in a patient with 46,XX true hermaphroditism. (1297452)
1992
47
Comparison of autocrine mechanisms promoting motility in two metastatic cell lines: human melanoma and ras-transfected NIH3T3 cells. (1657797)
1991
48
Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. (3920526)
1985
49
Experimental evidence for a theory of hypnotic behavior: 1. "Hypnotic color-blindness" without "hypnosis". (13686783)
1961
50
Tuberculous Epididymitis in a Boy aged 9, with Pulmonary Infection of Three Younger Sibs. (19991315)
1937

Variations for Macrocytic Anemia

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Expression for genes affiliated with Macrocytic Anemia

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Search GEO for disease gene expression data for Macrocytic Anemia.

Pathways for genes affiliated with Macrocytic Anemia

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Pathways related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.6RPS10, RPS17, RPS19, RPS24, RPS26, RPS7
2
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
3
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
4
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
5
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
6
Show member pathways
6.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
7
Show member pathways
5.9KITLG, RPL11, RPL15, RPL26, RPL35A, RPL5
8
Show member pathways
5.5ADH1B, ALAS2, RPL11, RPL15, RPL26, RPL35A

GO Terms for genes affiliated with Macrocytic Anemia

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Cellular components related to Macrocytic Anemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1small ribosomal subunitGO:001593510.4RPS24, RPS26
2ribosomeGO:00058409.4RPL35A, RPS10, RPS19, RPS26, RPS7
3extracellular exosomeGO:00700628.9RPS10, RPS17, RPS19, RPS26, RPS7
4cytosolGO:00058298.5RPL15, RPL26, RPL35A, RPL5, RPS24, RPS7
5membraneGO:00160206.7RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10

Biological processes related to Macrocytic Anemia according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1translational elongationGO:000641410.2RPS10, RPS17, RPS19
2cytoplasmic translationGO:00021819.9RPL15, RPL26, RPL35A
3ribosomal small subunit biogenesisGO:00422749.6RPS17, RPS19, RPS24, RPS7
4erythrocyte differentiationGO:00302189.4ALAS2, RPS19
5gene expressionGO:00104679.1RPL11, RPL15, RPL26, RPL35A
6nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:00001849.1RPL11, RPL5, RPS10, RPS17, RPS19
7viral transcriptionGO:00190838.7RPL11, RPS10, RPS17, RPS19, RPS24, RPS26
8translational terminationGO:00064158.4RPL11, RPL15, RPL26, RPL35A, RPS10, RPS17
9SRP-dependent cotranslational protein targeting to membraneGO:00066147.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
10translational initiationGO:00064137.3RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
11viral life cycleGO:00190587.1RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
12viral processGO:00160327.1RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10
13rRNA processingGO:00063646.9RPL11, RPL15, RPL26, RPL35A, RPL5, RPS10

Sources for Macrocytic Anemia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet