MCID: MCR017
MIFTS: 44

Macrocytic Anemia malady

Summaries for Macrocytic Anemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 The term macrocytic is from Greek words meaning \"large cell\". A macrocytic class of anemia is an... more...

MalaCards: Macrocytic Anemia, also known as anemia macrocytic, is related to deficiency anemia and megaloblastic anemia. An important gene associated with Macrocytic Anemia is TCN2 (transcobalamin II), and among its related pathways are Heme Biosynthesis and Cobalamin (Cbl, vitamin B12) transport and metabolism. The compounds hydroxymethylbilane and uroporphyrinogen-iii have been mentioned in the context of this disorder. Affiliated tissues include liver, small intestine and bone.

Aliases & Classifications for Macrocytic Anemia

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

macrocytic anemia 8
anemia macrocytic 8 44
macrocytic anaemia of unspecified cause 8
macrocytic anemia of unspecified cause 8
anemia, macrocytic 60


External Ids:

Disease Ontology8 DOID:2361
NCIt39 C34381
MeSH34 D000748

Related Diseases for Macrocytic Anemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Macrocytic Anemia:



Diseases related to macrocytic anemia

Clinical Features for Macrocytic Anemia

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Drugs & Therapeutics for Macrocytic Anemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Macrocytic Anemia

Drug clinical trials:

Search ClinicalTrials for Macrocytic Anemia

Search NIH Clinical Center for Macrocytic Anemia

Search CenterWatch for Macrocytic Anemia

Genetic Tests for Macrocytic Anemia

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Anatomical Context for Macrocytic Anemia

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32MalaCards
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MalaCards organs/tissues related to Macrocytic Anemia:

32
Liver, Small intestine, Bone, Bone marrow, Testes

Animal Models for Macrocytic Anemia or affiliated genes

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Publications for Macrocytic Anemia

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50PubMed
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Articles related to Macrocytic Anemia:

(show top 50)    (show all 134)
idTitleAuthorsYear
1
Amisulpride-induced macrocytic anemia. (23487206)
2013
2
Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. (24119684)
2013
3
Coprophagia and pica in individuals with mild to moderate dementia and mixed (iron deficiency and macrocytic) anemia. (22188083)
2011
4
A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome. (19966810)
2010
5
Pancytopenia, including macrocytic anemia, associated with leflunomide in a rheumatoid arthritis patient. (17929140)
2007
6
Azathioprine-induced fatal macrocytic anemia in rabbits. (12593539)
2002
7
Macrocytic anemia and thrombocytosis associated with thymoma: a case report. (10602167)
2000
8
High prevalence of atrophic body gastritis in patients with unexplained microcytic and macrocytic anemia: a prospective screening study. (10086664)
1999
9
Vitamin supplements improve the fertility potential of a subfertile male with macrocytic anemia--a case study. (7795372)
1994
10
A practical approach to the differential diagnosis and evaluation of the adult patient with macrocytic anemia. (1578958)
1992
11
Macrocytic anemia, thrombocytosis, and nonlobulated megakaryocytes (5q-syndrome): report of a case. (3949554)
1986
12
Hypothyroidism causing macrocytic anemia unresponsive to B12 and folate. (6864824)
1983
13
Macrocytic anemia, thrombocytosis and nonlobulated megakaryocytes: the 5q-syndrome, a distinct entity. (453227)
1979
14
Investigation of macrocytic anemia. (368738)
1979
15
Cytochemical study of granulopoietic tissue. 3. Megaloblastic and macrocytic anemia. (5020392)
1972
16
Nutritional macrocytic anemia of infancy and childhood. (5475355)
1970
17
Gastrointestinal lesions causing macrocytic anemia. (5826211)
1965
18
Diverticulosis of the jejunum with macrocytic anemia and steatorrhea. (14447714)
1961
19
Severe nutritional macrocytic anemia in emotionally disturbed patients. (13520639)
1958
20
Diverticulosis of the small intestine and macrocytic anemia with radioactive vitamin B12 absorption studies. (13645778)
1958
21
On macrocytic anemia with and without megaloblastosis in the tropics. (13545662)
1958
22
Macrocytic anemia in diseases of the small intestine. (13501366)
1958
23
Pathogenesis and treatment of macrocytic anemia; information obtained with radioactive vitamin B12. (13361587)
1956
24
RELATION between vitamin B12 and macrocytic anemia. (13211347)
1955
25
Macrocytic anemia associated with intestinal strictures and anastomoses: report of two cases. (13139137)
1954
26
The differential diagnosis of macrocytic anemia. (13052513)
1953
27
Macrocytic anemia and Sato's bromsulfalein test in children with nutritional dystrophy. (13038764)
1952
28
FOLIC acid deficiency in macrocytic anemia of pregnancy and infancy. (14907394)
1952
29
Nutritional dystrophy with or without macrocytic anemia; studies on the nutrition of children in Hirosaki area. (14922417)
1951
30
Macrocytic anemia and impaired liver function in eczematous and certain other dermatoses. (14782693)
1950
31
Hemolytic macrocytic anemia. (15406291)
1950
32
The experimental production of macrocytic anemia by operations of the intestinal tract. (18150157)
1949
33
Refined liver extract in tropical macrocytic anemia. (18110688)
1949
34
Neurologic sequelae in macrocytic anemia of gastrointestinal origin following folic acid therapy. (18889324)
1948
35
Macrocytic anemia; report of a case one month postpartum. (18857036)
1948
36
The effect of liver extract and vitamin B12 on the mucous membrane lesions of macrocytic anemia. (18877051)
1948
37
Macrocytic anemia. (18858389)
1948
38
Observations on the bone marrow of persons with chronic hepatic insufficiency and macrocytic anemia. (18873823)
1948
39
The PRESENT status of folic acid in the therapy of macrocytic anemia. (18902639)
1948
40
Absence of a Macrocytic Anemia in Dogs Fed Choline or Choline Plus Fat. (17788565)
1947
41
Effect of extrinsic factor, liver extract, and folic acid on induced macrocytic anemia of swine. (20272771)
1947
42
Synthetic folic acid; the effectiveness of a conjugated form in the treatment of tropical sprue, addisonian pernicious anemia and nutritional macrocytic anemia. (20293021)
1947
43
The effect of folic acid on the blood picture in human macrocytic anemia. (21064560)
1946
44
FOLIC acid in macrocytic anemia. (21027185)
1946
45
The treatment of macrocytic anemia with Lactobacillus casei factor (pteroylglutamic acid). (20274104)
1946
46
PTERINS and macrocytic anemia factors. (20275442)
1946
47
SYNTHETIC folic acid in macrocytic anemia. (21015931)
1946
48
Further studies on folic acid in the treatment of macrocytic anemia. (21004150)
1945
49
Macrocytic Anemia in Liver Disease. (18746158)
1942
50
COMPARISON OF HEMATOPOIESIS IN THE FETUS AND DURING RECOVERY FROM PERNICIOUS ANEMIA: TOGETHER WITH A CONSIDERATION OF THE RELATIONSHIP OF FETAL HEMATOPOIESIS TO MACROCYTIC ANEMIA OF PREGNANCY AND ANEMIA IN INFANTS. (16694355)
1935

Genetic Variations for Macrocytic Anemia

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Expression for genes affiliated with Macrocytic Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macrocytic Anemia

Search GEO for disease gene expression data for Macrocytic Anemia.

Pathways for genes affiliated with Macrocytic Anemia

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37NCBI BioSystems Database, 53Reactome, 29KEGG
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Pathways related to Macrocytic Anemia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0FECH, UROD
29.6TCN2, MTR
3
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9.6TCN2, MTR
4
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7.5RPS26, RPS19, RPS14, RPS7, RPS17, RPS10
5
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6.4RPS7, RPS14, RPS19, RPS26, RPL5, RPS17
6
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6.4RPS26, RPS19, RPS14, RPS7, RPL5, RPS17
7
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6.4RPS14, RPS19, RPS26, RPS7, RPL5, RPS17
86.4RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
9
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6.4RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5

Compounds for genes affiliated with Macrocytic Anemia

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Macrocytic Anemia according to GeneCards/GeneDecks:

(show all 20)
idCompoundScoreTop Affiliating Genes
1hydroxymethylbilane44 2411.3UROD, FECH
2uroporphyrinogen-iii4410.3FECH, UROD
3protoporphyrinogen4410.3FECH, UROD
4pyrrole4410.2UROD, FECH
5formyl-coa44 2411.2UROD, FECH
6porphyrin4410.2FECH, UROD
7porphobilinogen44 11 2412.1FECH, UROD
85-aminolevulinic acid44 2411.0UROD, FECH
9corrinoid4410.0TCN2, MTR
10adenosylcobalamin44 2410.9MTR, TCN2
11methylcobalamin44 2410.9TCN2, MTR
12protoporphyrin ix44 11 2411.9FECH, UROD
13cyanocobalamin49 11 2411.9MTR, TCN2
14hydroxocobalamin44 1110.9MTR, TCN2
15cystathionine449.8TCN2, MTR
16vitamin b6449.7TCN2, MTR, FECH
17methylmalonic acid44 2410.7MTR, TCN2
18haem449.7UROD, FECH
19cobalamin44 2410.6TCN2, MTR
20rrna449.6RPS19, RPL5, RPL11

GO Terms for genes affiliated with Macrocytic Anemia

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16Gene Ontology
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Cellular components related to Macrocytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1small ribosomal subunitGO:0159359.7RPS24, RPS26
2cytosolic large ribosomal subunitGO:0226259.1RPL35A, RPL11, RPL5
3ribosomeGO:0058409.1RPS19, RPS7, RPS17, RPS10
4cytosolic small ribosomal subunitGO:0226277.6RPS24, RPS26, RPS19, RPS14, RPS7, RPS17
5nucleolusGO:0057306.9RPS19, RPS14, RPS7, RPL5, RPL11, RPS10
6cytosolGO:0058295.6RPS26, RPS19, RPS14, RPS7, RPL5, RPS17

Biological processes related to Macrocytic Anemia according to GeneCards/GeneDecks:

(show all 24)
idNameGO IDScoreTop Affiliating Genes
1heme biosynthetic processGO:00678310.0UROD, FECH
2porphyrin-containing compound metabolic processGO:0067789.9UROD, FECH
3erythrocyte homeostasisGO:0341019.7RPS17, RPS24
4ribosomal large subunit biogenesisGO:0422739.6RPL35A, RPL11, RPL5
5maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)GO:0004629.6RPS24, RPS19
6cobalamin metabolic processGO:0092359.3TCN2, MTR
7maturation of SSU-rRNAGO:0304909.3RPS14, RPS19
8ribosomal small subunit assemblyGO:0000289.1RPS17, RPS14, RPS19
9ribosomal small subunit biogenesisGO:0422749.1RPS19, RPS7, RPS17, RPS24
10erythrocyte differentiationGO:0302189.1RPS19, RPS14, FECH
11rRNA processingGO:0063648.1RPS19, RPS7, RPL5, RPS17, RPL11, RPL35A
12SRP-dependent cotranslational protein targeting to membraneGO:0066146.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
13RNA metabolic processGO:0160706.7RPS17, RPL5, RPS7, RPS14, RPS19, RPS26
14mRNA metabolic processGO:0160716.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
15viral life cycleGO:0190586.7RPS26, RPS19, RPS14, RPS7, RPS24, RPS10
16viral transcriptionGO:0190836.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decayGO:0001846.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
18translationGO:0064126.7RPS17, RPL5, RPS7, RPS14, RPS19, RPS26
19translational initiationGO:0064136.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
20translational elongationGO:0064146.7RPS26, RPS19, RPS14, RPS24, RPS10, RPL35A
21translational terminationGO:0064156.7RPS24, RPS10, RPL35A, RPL11, RPS17, RPL5
22viral processGO:0160326.7RPS7, RPS14, RPS19, RPS26, RPL5, RPS17
23cellular protein metabolic processGO:0442676.6RPS7, RPS14, RPS19, RPS26, RPL5, RPS17
24gene expressionGO:0104676.6RPS26, RPS19, RPS14, RPS7, RPL5, RPS17

Molecular functions related to Macrocytic Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cobalamin bindingGO:0314199.6TCN2, MTR
2structural constituent of ribosomeGO:0037356.4RPS24, RPS26, RPS19, RPS14, RPS7, RPL5

Products for genes affiliated with Macrocytic Anemia

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Sources for Macrocytic Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet