MCID: MCR004
MIFTS: 54

Macroglobulinemia malady

Metabolic diseases category

Summaries for Macroglobulinemia

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Wikipedia:64 Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is... more...

MalaCards based summary: Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to cryoglobulinemia and polyneuropathy. An important gene associated with Macroglobulinemia is MYD88 (myeloid differentiation primary response 88), and among its related pathways are Cytokine production by Th17 cells in CF and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The drugs cyclophosphamide and thalidomide and the compounds blys and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are respiratory system and normal.

Aliases & Classifications for Macroglobulinemia

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Macroglobulinemia, Aliases & Descriptions:

Name: Macroglobulinemia 9 11
Waldenstrom Macroglobulinemia 61
 
Primary Macroglobulinemia 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Metabolic diseases


External Ids:

Disease Ontology9 DOID:9080
ICD9CM28 273.3
MeSH34 D008258

Related Diseases for Macroglobulinemia

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Diseases related to Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia31.1CD40LG
2polyneuropathy30.9CD40LG
3myeloma30.7IGHM, IRF4, CD40LG, CD40
4chronic lymphocytic leukemia30.5ZAP70, MS4A1, IGHM
5autoimmune hemolytic anemia30.4CD59, CD40LG
6agammaglobulinemia30.2CD40LG, IGHM
7hairy cell leukemia30.2ADA, CD40
8hemolytic anemia30.2CD59, ADA
9b-cell lymphomas30.0IGHM, IRF4, MS4A1, ZAP70, CD40
10plasmacytoma30.0CD40, IRF4
11prolymphocytic leukemia30.0ZAP70, ADA
12malt lymphoma29.9IGHM, IRF4, ZAP70, CD40
13leukemia29.6IRF4, ADA, ZAP70, CD40LG, CD59, CD40
14non-hodgkin lymphoma29.2IRF4, ADA, MS4A1, CD59, CD40
15acute lymphoblastic leukemia29.1IRF4, ADA, ZAP70, CD59, CD40
16macroglobulinemia, waldenstrom, somatic28.5CD40, HAS1, IGHM, CD59, CD40LG, ZAP70
17rheumatoid arthritis28.5HAS1, IGHM, ADA, ZAP70, CD40LG, CD59
18waldenstrom macroglobulinemia10.9
19lymphoplasmacytic lymphoma10.7
20multiple myeloma10.5
21cd40 ligand deficiency10.5CD40LG
22amyloidosis10.4
23neuropathy10.3
24cryoglobulinemic vasculitis10.3CD40LG, IGHM
25hepatitis10.3
26primary immunodeficiency disease10.3CD40LG, CD40
27malignant spiradenoma10.3CD40, CD40LG
28cd40 deficiency10.2CD40, CD40LG
29bruton-type agammaglobulinemia10.2CD40, IGHM
30blood protein disease10.2CD40, CD40LG
31immunodeficiency with hyper igm type 110.2CD40, CD40LG
32diffuse large b-cell lymphoma10.2
33glomerulonephritis10.2
34splenic marginal zone lymphoma10.2
35nephrotic syndrome10.2
36common variable immunodeficiency10.2CD40, CD40LG
37marginal zone b-cell lymphoma10.2
38hepatitis c10.2
39retinitis10.2
40lupus nephritis10.2CD40, CD40LG
41vasculitis10.2CD40LG, IGHM
42peripheral t-cell lymphoma10.1ZAP70, MS4A1
43mantle cell lymphoma10.1
44thrombocytopenia10.1
45mononeuritis multiplex10.1
46mononeuritis10.1
47splenomegaly10.1
48influenza10.1ADA, MYD88, HAS1
49connective tissue disease10.0CD40, CD40LG
50acute leukemia10.0

Graphical network of the top 20 diseases related to Macroglobulinemia:



Diseases related to macroglobulinemia

Symptoms for Macroglobulinemia

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Drugs & Therapeutics for Macroglobulinemia

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Drug clinical trials:

Search ClinicalTrials for Macroglobulinemia

Search NIH Clinical Center for Macroglobulinemia

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Macroglobulinemia

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Anatomical Context for Macroglobulinemia

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MalaCards organs/tissues related to Macroglobulinemia:

32
Bone, Bone marrow, B cells, Liver, Spleen, Lymph node, T cells, Kidney, Lung, Myeloid, Brain, Colon, Skin, Eye, Spinal cord, Heart, Small intestine, Breast, Ovary, Cervix, Tonsil, Monocytes

Animal Models for Macroglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Macroglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7ZAP70, ADA, MYD88, IGHM
2MP:00028738.0HAS1, IGHM, ADA, ZAP70, CD40
3MP:00053907.8IGHM, MYD88, ADA, ZAP70, CD40LG, CD40
4MP:00053677.7IGHM, MYD88, ADA, CD40LG, CD59, CD40
5MP:00053767.3IGHM, MYD88, ADA, CD40LG, CD59, CD40
6MP:00053877.0IGHM, MYD88, IRF4, ADA, MS4A1, ZAP70
7MP:00053976.2CD40, IGHM, MYD88, IRF4, ADA, MS4A1

Publications for Macroglobulinemia

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Articles related to Macroglobulinemia:

(show top 50)    (show all 641)
idTitleAuthorsYear
1
Extramedullary WaldenstrAPm Macroglobulinemia. (25349134)
2014
2
Treatment recommendations for patients with WaldenstrAPm macroglobulinemia (WM) and related disorders: IWWM-7 consensus. (25027391)
2014
3
Fludarabine in Waldenstrom's macroglobulinemia. (23782076)
2013
4
Waldenstrom macroglobulinemia presenting as isolated persistent epistaxis: a very rare presentation. (24427564)
2013
5
Rituximab Improves Subclinical Temporal Dispersion of Distal Compound Muscle Action Potential in Anti-MAG/SGPG Neuropathy Associated with WaldenstrAPm Macroglobulinemia: A Case Report. (23525653)
2013
6
Immunoglobulin M concentration in WaldenstrAPm macroglobulinemia: correlation with bone marrow B cells and plasma cells. (23523273)
2013
7
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms. (23355535)
2013
8
A single-arm, phase II study of the anti-Blys monoclonal antibody belimumab in symptomatic Waldenstrom macroglobulinemia. (23773449)
2013
9
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
10
Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenstrom macroglobulinemia. (22896002)
2012
11
The Case a8L Hyperbicarbonatemia in a patient with Waldenstrom's macroglobulinemia. Pseudohyperbicarbonatemia due to paraproteinemia. (22373713)
2012
12
WaldenstrAPm's macroglobulinemia-associated renal amyloidosis presenting as a solitary lung mass. (22950818)
2012
13
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. (22976953)
2012
14
Anti-angiogenic therapies in the treatment of Waldenstrom's Macroglobulinemia. (21933107)
2011
15
Pathogenesis and morbidity of autoantibody syndromes in Waldenstrom's macroglobulinemia. (21454221)
2011
16
IgM monoclonal gammopathy of undetermined significance (MGUS) and smoldering WaldenstrAPm's macroglobulinemia (SWM). (21454195)
2011
17
Hepcidin is produced by lymphoplasmacytic cells and is associated with anemia in WaldenstrAPm's macroglobulinemia. (21454222)
2011
18
Expression of CCL3 by neoplastic cells in patients with WaldenstrAPm's macroglobulinemia: an immunohistochemical study in bone marrow biopsies of 67 patients. (21454208)
2011
19
WaldenstrAPm's macroglobulinemia in a dog with a bleeding diathesis. (21827519)
2011
20
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. (19965685)
2010
21
Successful treatment of cryoglobulinemic glomerulonephritis derived from WaldenstrAPm's macroglobulinemia by rituximab-CHOP and tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation. (20686877)
2010
22
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
23
Update on therapeutic options in WaldenstrAPm macroglobulinemia. (19087134)
2009
24
Long-term outcomes to fludarabine and rituximab in WaldenstrAPm macroglobulinemia. (19015393)
2009
25
High-resolution genomic analysis in WaldenstrAPm's macroglobulinemia identifies disease-specific and common abnormalities with marginal zone lymphomas. (19362969)
2009
26
Lumbar spinal nerve root hypertrophy in WaldenstAPm's macroglobulinemia-associated polyneuropathy with antisulphated glucuronyl paragloboside antibody. (19797839)
2009
27
Neurological manifestations of WaldenstrAPm macroglobulinemia. (18813229)
2008
28
Malignant hematopoietic cell lines: in vitro models for the study of WaldenstrAPm's macroglobulinemia. (18533260)
2008
29
SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. (18448868)
2008
30
WSU-WM and BCWM.1 should not be assumed to represent WaldenstrAPm macroglobulinemia cell lines. (18650470)
2008
31
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
32
Recognizing hyperviscosity syndrome in patients with Waldenstrom macroglobulinemia. (17441400)
2007
33
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. (16304043)
2006
34
Advanced WaldenstrAPm's macroglobulinemia: usefulness of Morel's scoring system in establishing prognosis. (15710594)
2005
35
Fludarabine plus cyclophosphamide in WaldenstrAPm's macroglobulinemia: results in 49 patients. (16121217)
2005
36
Analysis of IgH translocations, chromosome 13q14 and 17p13.1(p53) deletions by fluorescence in situ hybridization in Waldenstrom's macroglobulinemia: a single center study of 22 cases. (15103388)
2004
37
Proinflammatory syndrome mimicking acute rheumatoid arthritis in a patient with Waldenstrom's macroglobulinemia treated with rituximab. (14513285)
2004
38
Treatment of Waldenstrom's macroglobulinemia with rituximab: prognostic factors for response and progression. (15370250)
2004
39
Circulating macroglobulinemia cells. (15468987)
2004
40
WaldenstrAPm's macroglobulinemia-associated retinopathy. (15019332)
2004
41
Interstitial deletion of 20q in a patient with WaldenstrAPm macroglobulinemia following chemotherapy. (11850077)
2002
42
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
43
B-chronic lymphocytic leukemia, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma, including WaldenstrAPm's macroglobulinemia: a clinical, morphologic, and biologic spectrum of similar disorders. (10319379)
1999
44
WaldenstrAPm's macroglobulinemia resulting from localized gastric lymphoplasmacytoid lymphoma. (9662279)
1998
45
WaldenstrAPm macroglobulinemia: MR imaging of the spine and CT of the abdomen and pelvis. (8351330)
1993
46
Xanthoma disseminatum and WaldenstrAPm's macroglobulinemia. (2121806)
1990
47
"Supernormal" bone image in a case of WaldenstrAPm macroglobulinemia. (3082557)
1986
48
Remission of acute myelogenous leukemia complicating WaldenstrAPm macroglobulinemia. (102080)
1978
49
PRIMARY MACROGLOBULINEMIA: DEATH DUE TO MESENTERIC VASCULAR OCCLUSION WITH GAS IN THE PORTAL VENOUS SYSTEM. (14226112)
1964
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Macroglobulinemia

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Expression for genes affiliated with Macroglobulinemia

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Expression patterns in normal tissues for genes affiliated with Macroglobulinemia

Search GEO for disease gene expression data for Macroglobulinemia.

Pathways for genes affiliated with Macroglobulinemia

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Pathways related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IRF4, MYD88
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
9.6CD40LG, IRF4
39.6CD40LG, IRF4
49.6CD40, CD40LG
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway59
9.6CD40LG, CD40
69.6CD40LG, CD40
7
Show member pathways
Immune response Alternative complement pathway59
Immune response Lectin Induced complement pathway59
Immune response Classic complement pathway59
9.3CD59, IGHM
8
Show member pathways
9.3CD40, CD40LG, MYD88
99.3CD40, CD40LG, MYD88
10
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.0IRF4, ZAP70, CD40LG
119.0ZAP70, CD40LG, CD40
128.7CD40, CD40LG, ZAP70, MYD88
13
Show member pathways
8.6CD40, CD40LG, ZAP70, IGHM
148.4CD40, CD40LG, ZAP70, ADA

Compounds for genes affiliated with Macroglobulinemia

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Compounds related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1blys4410.0CD40LG, CD40
2tuberculin449.9CD40LG, ADA
3ranitidine44 29 25 1212.9CD40LG, ADA
4abciximab44 1210.9CD40LG, CD40
52-chlorodeoxyadenosine449.9ADA, CD40LG
6clopidogrel44 50 25 1212.9CD40, CD40LG
7fluorochrome449.8CD40LG, ZAP70
8okt3449.8CD40LG, ZAP70
9mycophenolate mofetil44 50 1211.8CD40, CD40LG
10galalpha(1,3)gal449.7CD59, CD40LG
11endotoxin449.7MYD88, CD40LG, CD40
12fenofibrate44 50 1211.6CD40, CD40LG
13hyaluronic acid44 2510.6CD40, CD40LG, HAS1
14rantes449.6MYD88, CD40LG, CD40
15ivig449.6CD40LG, CD40
16allergens449.6CD40, CD40LG
17ribavirin44 50 1211.5CD40LG, ADA
18neopterin449.5ADA, CD40LG, CD40
19biotin44 25 1211.5CD40, CD40LG, ADA
20indomethacin44 29 60 1212.4CD40, CD40LG, ADA
21fitc449.3ZAP70, CD59
22paraffin449.3MS4A1, CD40LG, CD40
23histamine44 29 2511.3ADA, CD40LG, CD40
24cyclophosphamide44 50 1211.3CD40, ZAP70, MS4A1
25vitamin b12449.3CD40LG, ADA
26doxorubicin44 50 1211.3CD40, CD40LG, ADA
27ganglioside449.2CD40, CD59, CD40LG
28atorvastatin44 50 29 25 1213.2CD40LG, CD59, CD40
29aspirin44 50 29 2512.1ADA, CD40LG, CD59
30genistein44 29 60 3 25 1214.1CD40, CD40LG, ZAP70
31cytidine44 25 1210.9CD40, CD40LG, ZAP70, ADA
32dexamethasone44 50 29 1211.8CD40, CD40LG, ZAP70, ADA
33cyclosporin a44 29 6010.6ADA, CD40LG, CD59, CD40
34phosphatidylinositol448.5CD40, CD59, ZAP70, MYD88
35lactate448.5ADA, ZAP70, CD40LG, CD59
36fludarabine44 50 1210.5CD40, CD40LG, ZAP70, MS4A1, ADA
37oxygen44 259.4CD40, CD59, ZAP70, MYD88
38atp44 299.4MYD88, ADA, ZAP70, CD59
39lipid448.2CD40, CD59, ZAP70, MS4A1, MYD88
40rituximab44 50 1210.2MS4A1, ZAP70, CD40LG, CD59, CD40

GO Terms for genes affiliated with Macroglobulinemia

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Cellular components related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.8CD59, ADA, IGHM
2external side of plasma membraneGO:0098978.7CD40, CD40LG, MS4A1, ADA
3integral component of plasma membraneGO:0058878.6CD40, CD40LG, MS4A1, HAS1
4extracellular spaceGO:0056157.7ADA, MS4A1, CD40LG, CD59, CD40
5plasma membraneGO:0058866.6HAS1, IGHM, MYD88, ADA, ZAP70, CD40LG

Biological processes related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:0510239.8CD40LG, CD40
2positive regulation of endothelial cell apoptotic processGO:20003539.7CD40, CD40LG
3cellular response to mechanical stimulusGO:0712609.7CD40, MYD88
4positive regulation of interleukin-12 productionGO:0327359.6CD40, CD40LG
5positive regulation of alpha-beta T cell differentiationGO:0466389.5ZAP70, ADA
6positive regulation of calcium-mediated signalingGO:0508509.4ADA, ZAP70
7positive regulation of B cell proliferationGO:0308909.4CD40, ADA
8B cell proliferationGO:0421009.4CD40, CD40LG, MS4A1
9adaptive immune responseGO:0022509.4IGHM, ZAP70
10T cell activationGO:0421109.1ZAP70, ADA, IRF4
11inflammatory responseGO:0069549.0CD40, CD40LG, MYD88

Molecular functions related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.6CD40, IGHM

Products for genes affiliated with Macroglobulinemia

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Sources for Macroglobulinemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet