MCID: MCR004
MIFTS: 48

Macroglobulinemia malady

Summaries for Macroglobulinemia

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Wikipedia:63 Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is... more...

MalaCards based summary: Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to cryoglobulinemia and polyneuropathy. An important gene associated with Macroglobulinemia is MYD88 (myeloid differentiation primary response 88), and among its related pathways are Cytokine production by Th17 cells in CF and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The drugs thalidomide and cyclophosphamide and the compounds blys and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are respiratory system and normal.

Aliases & Classifications for Macroglobulinemia

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Macroglobulinemia, Aliases & Descriptions:

Name: Macroglobulinemia 9 11
Waldenstrom Macroglobulinemia 60
 
Primary Macroglobulinemia 9


External Ids:

Disease Ontology9 DOID:9080
MeSH33 D008258
ICD9CM27 273.3

Related Diseases for Macroglobulinemia

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Diseases related to Macroglobulinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1cryoglobulinemia31.1CD40LG
2polyneuropathy30.9CD40LG
3myeloma30.7IGHM, IRF4, CD40LG, CD40
4autoimmune hemolytic anemia30.4CD59, CD40LG
5agammaglobulinemia30.2CD40LG, IGHM
6hemolytic anemia30.2CD59, ADA
7plasmacytoma30.0CD40, IRF4
8b-cell lymphomas30.0IGHM, IRF4, MS4A1, ZAP70, CD40
9prolymphocytic leukemia30.0ZAP70, ADA
10chronic lymphocytic leukemia29.9IGHM, MS4A1, ZAP70, CD40LG, CD40
11malt lymphoma29.9IGHM, IRF4, ZAP70, CD40
12leukemia29.6IRF4, ADA, ZAP70, CD40LG, CD59, CD40
13waldenstrom macroglobulinemia29.5CD40, HAS1, IGHM, CD59, CD40LG, ZAP70
14hodgkin lymphoma29.5CD40, ZAP70, MS4A1, IRF4, IGHM
15rheumatoid arthritis28.5HAS1, IGHM, ADA, ZAP70, CD40LG, CD59
16lymphoplasmacytic lymphoma10.7
17multiple myeloma10.5
18x-linked hyper igm syndrome10.5CD40LG
19amyloidosis10.4
20macroglobulinemia, waldenstrom, somatic10.4
21neuropathy10.3
22cryoglobulinemia, familial mixed10.3CD40LG, IGHM
23diffuse large b-cell lymphoma10.3
24hepatitis10.3
25primary immunodeficiency disease10.3CD40LG, CD40
26malignant spiradenoma10.2CD40, CD40LG
27cd40 deficiency10.2CD40, CD40LG
28agammaglobulinemia, x-linked 110.2CD40, IGHM
29blood protein disease10.2CD40, CD40LG
30immunodeficiency, x-linked, with hyper-igm10.2CD40, CD40LG
31glomerulonephritis10.2
32splenic marginal zone lymphoma10.2
33nephrotic syndrome10.2
34common variable immunodeficiency10.2CD40, CD40LG
35marginal zone b-cell lymphoma10.2
36thrombocytopenia10.2
37hepatitis c10.2
38retinitis10.2
39lupus nephritis10.2CD40, CD40LG
40vasculitis10.1CD40LG, IGHM
41hcl-v10.1ADA, CD40
42peripheral t-cell lymphoma10.1ZAP70, MS4A1
43mantle cell lymphoma10.1
44mononeuritis multiplex10.1
45schnitzler syndrome10.1
46mononeuritis10.1
47splenomegaly10.1
48influenza10.1ADA, MYD88, HAS1
49squamous cell carcinoma, head and neck10.0ZAP70, MS4A1, IGHM
50chromosomal triplication10.0IGHM, ZAP70

Graphical network of the top 20 diseases related to Macroglobulinemia:



Diseases related to macroglobulinemia

Symptoms for Macroglobulinemia

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Drugs & Therapeutics for Macroglobulinemia

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Drug clinical trials:

Search ClinicalTrials for Macroglobulinemia

Search NIH Clinical Center for Macroglobulinemia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Macroglobulinemia

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Anatomical Context for Macroglobulinemia

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MalaCards organs/tissues related to Macroglobulinemia:

31
Bone, Bone marrow, B cells, Liver, Spleen, Lymph node, T cells, Kidney, Lung, Myeloid, Brain, Colon, Skin, Eye, Spinal cord, Heart, Small intestine, Breast, Ovary, Cervix, Tonsil, Monocytes

Animal Models for Macroglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Macroglobulinemia:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7IGHM, MYD88, ZAP70, ADA
2MP:00028738.0IGHM, HAS1, CD40, ZAP70, ADA
3MP:00053907.8IGHM, CD40, CD40LG, ZAP70, ADA, MYD88
4MP:00053677.7MYD88, IGHM, ADA, CD40LG, CD59, CD40
5MP:00053767.3CD40, CD59, CD40LG, ADA, MYD88, IGHM
6MP:00053877.0CD40, CD40LG, ZAP70, MS4A1, ADA, IRF4
7MP:00053976.2MYD88, IGHM, CD40, CD59, ZAP70, CD40LG

Publications for Macroglobulinemia

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Articles related to Macroglobulinemia:

(show top 50)    (show all 672)
idTitleAuthorsYear
1
WaldenstrAPm's macroglobulinemia: The role of hospital transfusion medicine laboratory in the diagnosis and management. (25722563)
2015
2
Bevacizumab therapy and multimodal ultrawide-field imaging in immunogammopathy maculopathy secondary to WaldenstrAPm's macroglobulinemia. (25707055)
2015
3
Interstitial pulmonary amyloidosis with WaldenstrAPm's macroglobulinemia. (25748748)
2015
4
Biology, prognosis, and therapy of WaldenstrAPm Macroglobulinemia. (25655610)
2015
5
Population-based study on the impact of the familial form of WaldenstrAPm macroglobulinemia on overall survival. (25814489)
2015
6
Interstitial pneumonitis related to rituximab therapy for WaldenstrAPm's macroglobulinemia. (25798285)
2015
7
Extramedullary WaldenstrAPm Macroglobulinemia. (25349134)
2014
8
Treatment recommendations for patients with WaldenstrAPm macroglobulinemia (WM) and related disorders: IWWM-7 consensus. (25027391)
2014
9
Fludarabine in Waldenstrom's macroglobulinemia. (23782076)
2013
10
Waldenstrom macroglobulinemia presenting as isolated persistent epistaxis: a very rare presentation. (24427564)
2013
11
Rituximab Improves Subclinical Temporal Dispersion of Distal Compound Muscle Action Potential in Anti-MAG/SGPG Neuropathy Associated with WaldenstrAPm Macroglobulinemia: A Case Report. (23525653)
2013
12
Immunoglobulin M concentration in WaldenstrAPm macroglobulinemia: correlation with bone marrow B cells and plasma cells. (23523273)
2013
13
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms. (23355535)
2013
14
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
15
Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenstrom macroglobulinemia. (22896002)
2012
16
The Case a8L Hyperbicarbonatemia in a patient with Waldenstrom's macroglobulinemia. Pseudohyperbicarbonatemia due to paraproteinemia. (22373713)
2012
17
WaldenstrAPm's macroglobulinemia-associated renal amyloidosis presenting as a solitary lung mass. (22950818)
2012
18
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. (22976953)
2012
19
Anti-angiogenic therapies in the treatment of Waldenstrom's Macroglobulinemia. (21933107)
2011
20
Development of diffuse large B-cell lymphoma in a patient with WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. (22184531)
2011
21
Pathogenesis and morbidity of autoantibody syndromes in Waldenstrom's macroglobulinemia. (21454221)
2011
22
IgM monoclonal gammopathy of undetermined significance (MGUS) and smoldering WaldenstrAPm's macroglobulinemia (SWM). (21454195)
2011
23
Hepcidin is produced by lymphoplasmacytic cells and is associated with anemia in WaldenstrAPm's macroglobulinemia. (21454222)
2011
24
Expression of CCL3 by neoplastic cells in patients with WaldenstrAPm's macroglobulinemia: an immunohistochemical study in bone marrow biopsies of 67 patients. (21454208)
2011
25
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. (19965685)
2010
26
Successful treatment of cryoglobulinemic glomerulonephritis derived from WaldenstrAPm's macroglobulinemia by rituximab-CHOP and tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation. (20686877)
2010
27
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
28
Update on therapeutic options in WaldenstrAPm macroglobulinemia. (19087134)
2009
29
Long-term outcomes to fludarabine and rituximab in WaldenstrAPm macroglobulinemia. (19015393)
2009
30
Neurological manifestations of WaldenstrAPm macroglobulinemia. (18813229)
2008
31
Malignant hematopoietic cell lines: in vitro models for the study of WaldenstrAPm's macroglobulinemia. (18533260)
2008
32
SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. (18448868)
2008
33
WSU-WM and BCWM.1 should not be assumed to represent WaldenstrAPm macroglobulinemia cell lines. (18650470)
2008
34
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
35
Recognizing hyperviscosity syndrome in patients with Waldenstrom macroglobulinemia. (17441400)
2007
36
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. (16304043)
2006
37
Fludarabine plus cyclophosphamide in WaldenstrAPm's macroglobulinemia: results in 49 patients. (16121217)
2005
38
Proinflammatory syndrome mimicking acute rheumatoid arthritis in a patient with Waldenstrom's macroglobulinemia treated with rituximab. (14513285)
2004
39
Treatment of Waldenstrom's macroglobulinemia with rituximab: prognostic factors for response and progression. (15370250)
2004
40
Circulating macroglobulinemia cells. (15468987)
2004
41
WaldenstrAPm's macroglobulinemia-associated retinopathy. (15019332)
2004
42
Interstitial deletion of 20q in a patient with WaldenstrAPm macroglobulinemia following chemotherapy. (11850077)
2002
43
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
44
B-chronic lymphocytic leukemia, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma, including WaldenstrAPm's macroglobulinemia: a clinical, morphologic, and biologic spectrum of similar disorders. (10319379)
1999
45
WaldenstrAPm's macroglobulinemia resulting from localized gastric lymphoplasmacytoid lymphoma. (9662279)
1998
46
Xanthoma disseminatum and WaldenstrAPm's macroglobulinemia. (2121806)
1990
47
"Supernormal" bone image in a case of WaldenstrAPm macroglobulinemia. (3082557)
1986
48
Remission of acute myelogenous leukemia complicating WaldenstrAPm macroglobulinemia. (102080)
1978
49
PRIMARY MACROGLOBULINEMIA: DEATH DUE TO MESENTERIC VASCULAR OCCLUSION WITH GAS IN THE PORTAL VENOUS SYSTEM. (14226112)
1964
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Macroglobulinemia

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Expression for genes affiliated with Macroglobulinemia

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Search GEO for disease gene expression data for Macroglobulinemia.

Pathways for genes affiliated with Macroglobulinemia

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Pathways related to Macroglobulinemia according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IRF4, MYD88
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
9.6CD40LG, IRF4
39.6CD40LG, IRF4
49.6CD40, CD40LG
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway58
9.6CD40LG, CD40
69.6CD40LG, CD40
7
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.3CD59, IGHM
8
Show member pathways
9.3CD40, CD40LG, MYD88
99.3CD40, CD40LG, MYD88
10
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.0IRF4, ZAP70, CD40LG
119.0ZAP70, CD40LG, CD40
128.7CD40, CD40LG, ZAP70, MYD88
13
Show member pathways
8.6CD40, CD40LG, ZAP70, IGHM
148.4CD40, CD40LG, ZAP70, ADA

Compounds for genes affiliated with Macroglobulinemia

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Compounds related to Macroglobulinemia according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
1blys4310.0CD40LG, CD40
2tuberculin439.9CD40LG, ADA
3ranitidine43 28 24 1212.9CD40LG, ADA
4abciximab43 1210.9CD40LG, CD40
52-chlorodeoxyadenosine439.9ADA, CD40LG
6clopidogrel43 49 24 1212.9CD40, CD40LG
7fluorochrome439.8CD40LG, ZAP70
8okt3439.8CD40LG, ZAP70
9mycophenolate mofetil43 49 1211.8CD40, CD40LG
10galalpha(1,3)gal439.7CD59, CD40LG
11endotoxin439.7MYD88, CD40LG, CD40
12fenofibrate43 49 1211.6CD40, CD40LG
13hyaluronic acid43 2410.6CD40, CD40LG, HAS1
14rantes439.6MYD88, CD40LG, CD40
15ivig439.6CD40LG, CD40
16allergens439.6CD40, CD40LG
17ribavirin43 49 1211.5CD40LG, ADA
18neopterin439.5ADA, CD40LG, CD40
19biotin43 24 1211.5CD40, CD40LG, ADA
20indomethacin43 28 59 1212.4CD40, CD40LG, ADA
21fitc439.3ZAP70, CD59
22paraffin439.3MS4A1, CD40LG, CD40
23histamine43 28 2411.3ADA, CD40LG, CD40
24cyclophosphamide43 49 1211.3CD40, ZAP70, MS4A1
25vitamin b12439.3CD40LG, ADA
26doxorubicin43 49 1211.3CD40, CD40LG, ADA
27ganglioside439.2CD40, CD59, CD40LG
28atorvastatin43 49 28 24 1213.2CD40LG, CD59, CD40
29aspirin43 49 28 2412.1ADA, CD40LG, CD59
30genistein43 28 59 2 24 1214.1CD40, CD40LG, ZAP70
31cytidine43 24 1210.9CD40, CD40LG, ZAP70, ADA
32dexamethasone43 49 28 1211.8CD40, CD40LG, ZAP70, ADA
33cyclosporin a43 28 5910.6ADA, CD40LG, CD59, CD40
34phosphatidylinositol438.5CD40, CD59, ZAP70, MYD88
35lactate438.5ADA, ZAP70, CD40LG, CD59
36fludarabine43 49 1210.5CD40, CD40LG, ZAP70, MS4A1, ADA
37oxygen43 249.4CD40, CD59, ZAP70, MYD88
38atp43 289.4MYD88, ADA, ZAP70, CD59
39lipid438.2CD40, CD59, ZAP70, MS4A1, MYD88
40rituximab43 49 1210.2MS4A1, ZAP70, CD40LG, CD59, CD40

GO Terms for genes affiliated with Macroglobulinemia

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Cellular components related to Macroglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.8CD59, ADA, IGHM
2external side of plasma membraneGO:00098978.7ADA, MS4A1, CD40LG, CD40
3integral component of plasma membraneGO:00058878.6CD40, HAS1, MS4A1, CD40LG
4extracellular spaceGO:00056157.7CD40, MS4A1, CD59, CD40LG, ADA
5plasma membraneGO:00058866.6HAS1, MYD88, ADA, ZAP70, CD40LG, CD59

Biological processes related to Macroglobulinemia according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:00510239.8CD40LG, CD40
2positive regulation of endothelial cell apoptotic processGO:020003539.7CD40, CD40LG
3cellular response to mechanical stimulusGO:00712609.7CD40, MYD88
4positive regulation of interleukin-12 productionGO:00327359.6CD40, CD40LG
5positive regulation of alpha-beta T cell differentiationGO:00466389.5ZAP70, ADA
6positive regulation of calcium-mediated signalingGO:00508509.4ADA, ZAP70
7positive regulation of B cell proliferationGO:00308909.4CD40, ADA
8B cell proliferationGO:00421009.4CD40, CD40LG, MS4A1
9adaptive immune responseGO:00022509.4IGHM, ZAP70
10T cell activationGO:00421109.1ZAP70, ADA, IRF4
11inflammatory responseGO:00069549.0CD40, CD40LG, MYD88

Molecular functions related to Macroglobulinemia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:00038239.6CD40, IGHM

Products for genes affiliated with Macroglobulinemia

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Sources for Macroglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet