MCID: MCR004
MIFTS: 55

Macroglobulinemia malady

Summaries for Macroglobulinemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is... more...

MalaCards: Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to myeloma and multiple myeloma. An important gene associated with Macroglobulinemia is HAS1 (hyaluronan synthase 1), and among its related pathways are Inflammatory Response Pathway and Classical antibody-mediated complement activation. The drugs cyclophosphamide and thalidomide and the compounds fluorochrome and 8-chloroadenosine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Macroglobulinemia

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

macroglobulinemia 8 10
waldenstrom macroglobulinemia 60
primary macroglobulinemia 8


External Ids:

Disease Ontology8 DOID:9080
MeSH34 D008258
ICD9CM27 273.3

Related Diseases for Macroglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma30.8PTPRC, PAX5, BIRC3, CD40LG, CD40, MAG
2multiple myeloma30.7CD40, IRF4, CCND1
3leukemia30.7CCND1, IRF4, ZAP70, CD40, CD40LG, CD59
4acute leukemia30.4BIRC3, PAX5, PTPRC
5macroglobulinemia, waldenstrom, somatic30.3IRF4, CCND1, HAS1, ZAP70, ADA, PTPRC
6cryoglobulinemia30.3CD40LG
7chronic lymphocytic leukemia30.3TNFRSF17, TNFRSF13C, CCND1, ADA, PTPRC, PAX5
8hepatitis30.2CD40LG
9hepatitis c30.1IGHM, CD40LG, PAX5
10myeloid leukemia29.9PTPRC
11hairy cell leukemia29.9CCND1, CD40, PTPRC, ADA
12lupus erythematosus29.7CD40LG
13arthritis29.7CD59
14hepatitis b29.7IGHM
15plasmacytoma29.7PTPRC, PAX5, CD40, IRF4
16prolymphocytic leukemia29.7CCND1, ZAP70, ADA
17multiple sclerosis29.7TNFRSF13C, TNFRSF17, MAG, CD40, CD59, PTPRC
18agammaglobulinemia29.7CD40LG, IGHM
19chronic myeloid leukemia29.7IRF4, CD59, BIRC3, PTPRC, ADA
20proteinuria29.7CD59, CD40LG
21rheumatoid arthritis29.7TNFRSF13C, TNFRSF17, HAS1, ZAP70, IGHM, CD40
22non-hodgkin lymphoma29.7CCND1, TNFRSF13C, ADA, PTPRC, PAX5, MS4A1
23breast cancer29.7ADA, BIRC3, CD59, CD40, HAS1, CCND1
24hematologic cancer29.7ADA, PAX5, ZAP70
25lymphoplasmacytic lymphoma10.6
26waldenstrom macroglobulinemia10.4
27amyloidosis10.3
28neuropathy10.3
29diffuse large b-cell lymphoma10.2
30splenic marginal zone lymphoma10.2
31glomerulonephritis10.2
32marginal zone b-cell lymphoma10.2
33nephrotic syndrome10.2
34autoimmune hemolytic anemia10.1
35hemolytic anemia10.1
36retinitis10.1
37mononeuritis multiplex10.1
38gastric lymphoma10.1
39mantle cell lymphoma10.1
40mononeuritis10.1
41polyneuropathy10.1
42thrombocytopenia10.1
43asthma10.0ZAP70
44hypersensitivity reaction type ii disease10.0CD40
45primary immunodeficiency disease10.0CD40, CD40LG
46myasthenia gravis10.0MAG
47lung cancer10.0CCND1
48plasma cell leukemia10.0CCND1, CD40
49common variable immune deficiency10.0CD40LG, CD40, TNFRSF13C
50sjogren's syndrome10.0CD40LG, CD40

Graphical network of the top 20 diseases related to Macroglobulinemia:



Diseases related to macroglobulinemia

Clinical Features for Macroglobulinemia

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Drugs & Therapeutics for Macroglobulinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Macroglobulinemia

Drug clinical trials:

Search ClinicalTrials for Macroglobulinemia

Search NIH Clinical Center for Macroglobulinemia

Search CenterWatch for Macroglobulinemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Macroglobulinemia

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Anatomical Context for Macroglobulinemia

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32MalaCards
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MalaCards organs/tissues related to Macroglobulinemia:

32
Bone, Bone marrow, B cells, Liver, Spleen, Lymph node, T cells, Kidney, Lung, Myeloid, Skin, Eye, Cervix, Colon, Small intestine, Ovary, Spinal cord, Monocytes, Brain, Breast, Heart, Tonsil

Animal Models for Macroglobulinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Macroglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4CD59, IGHM
2MP:000539710.2ADA, CCND1, TNFRSF13C, TNFRSF17, IRF4, ZAP70
3MP:000538710.2ZAP70, IRF4, TNFRSF17, TNFRSF13C, CCND1, IGHM
4MP:000538410.1IGHM, ZAP70, IRF4, TNFRSF13C, CCND1, CD40
5MP:000287310.1CCND1, TNFRSF17, HAS1, ZAP70, IGHM, CD40
6MP:000539010.0CCND1, IGHM, CD40, CD40LG, PAX5, PTPRC

Publications for Macroglobulinemia

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50PubMed
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Articles related to Macroglobulinemia:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
WaldenstrAPm macroglobulinemia: from biology to treatment. (24405328)
2014
2
Genetic factors and pathogenesis of WaldenstrAPm's macroglobulinemia. (23901022)
2013
3
Radiographic findings in WaldenstrAPm's macroglobulinemia resembling fibrogenesis imperfecta ossium (FIO): A case report. (24072255)
2013
4
Histidine based adsorbents for selective removal of monoclonal immunoglobulin IgM antibodies from Waldenstrom's macroglobulinemia patient sera: a preliminary study. (23811496)
2013
5
Primary therapy of Waldenstrom macroglobulinemia (WM) with weekly bortezomib, low-dose dexamethasone, and rituximab (BDR): long-term results of a phase 2 study of the European Myeloma Network (EMN). (24004667)
2013
6
Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory WaldenstrAPm macroglobulinemia. (23287861)
2013
7
microRNA aberrations in WaldenstrAPm macroglobulinemia. (23474146)
2013
8
Waldenstrom macroglobulinemia with a durable clinical response to epoetin beta. (22260157)
2012
9
WaldenstrAPm macroglobulinemia transforming from t (11;18) (q21;q21) -negative gastric MALT lymphoma after systemic dissemination. (22880230)
2012
10
Pseudovitelliform Subfoveal Deposit in WaldenstrAPm's Macroglobulinemia. (22949912)
2012
11
Hematopoietic cell transplantation for WaldenstrAPm macroglobulinemia. (21572463)
2012
12
Eph-B2/ephrin-B2 interaction plays a major role in the adhesion and proliferation of Waldenstrom's macroglobulinemia. (22010211)
2012
13
New insights into the pathogenesis and treatment of Waldenstrom macroglobulinemia. (21519243)
2011
14
MicroRNA expression in tumor cells from Waldenstrom's macroglobulinemia reflects both their normal and malignant cell counterparts. (22829168)
2011
15
WaldenstrAPm macroglobulinemia with pseudo-Gaucher cells. (21089228)
2010
16
Waldenstrom's macroglobulinemia: Recent advances in biology and therapy. (20040909)
2009
17
Distal renal tubular acidosis in lymphoplasmacytic lymphoma WaldenstrAPm's macroglobulinemia: a case report. (19829932)
2009
18
How I treat WaldenstrAPm macroglobulinemia. (19617573)
2009
19
Balancing risk versus benefit in the treatment of WaldenstrAPm's Macroglobulinemia patients with nucleoside analogue-based therapy. (19362978)
2009
20
WSU-WM and BCWM.1 should not be assumed to represent WaldenstrAPm macroglobulinemia cell lines. (18650470)
2008
21
Durable remission of large B-cell lymphoma transformed from lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia successfully treated with sequential immunochemotherapy followed by reduced-intensity allogeneic stem cell transplantation. (18071292)
2008
22
Acute renal failure secondary to severe type I cryoglobulinemia following rituximab therapy for WaldenstrAPm's macroglobulinemia. (18288560)
2008
23
Waldenstrom macroglobulinemia. (18555588)
2008
24
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
25
IgM-expressing Waldenstrom's macroglobulinemia tumor cells reveal a potential for isotype switch events in vivo. (17287856)
2007
26
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. (16304043)
2006
27
Autologous or allogeneic stem cell transplantation in patients with Waldenstrom's macroglobulinemia. (16864055)
2006
28
The amino acid sequence of an AL-protein, AL-KH, isolated from the heart of a patient with Waldenstroms macroglobulinemia and amyloidosis. (17107886)
2006
29
Low-grade T-cell lymphoma of the kidney and WaldenstrAPm's macroglobulinemia in a patient presenting with renal failure. (16792141)
2006
30
Cutaneous Waldenstrom's macroglobulinemia with "deck-chair" sign treated with cyclophosphamide. (15692513)
2005
31
Autoantibody activity in Waldenstrom's macroglobulinemia. (15794853)
2005
32
CHOP plus rituximab therapy in Waldenstrom's macroglobulinemia. (15794864)
2005
33
Analysis of IgH translocations, chromosome 13q14 and 17p13.1(p53) deletions by fluorescence in situ hybridization in Waldenstrom's macroglobulinemia: a single center study of 22 cases. (15103388)
2004
34
Circulating macroglobulinemia cells. (15468987)
2004
35
The international staging system for multiple myeloma is applicable in symptomatic Waldenstrom's macroglobulinemia. (15223640)
2004
36
WaldenstrAPm's macroglobulinemia: prognostic factors and recent therapeutic advances. (15103509)
2004
37
Use of fludarabine in the treatment of mantle cell lymphoma, WaldenstrAPm's macroglobulinemia and other uncommon B- and T-cell lymphoid malignancies. (15079153)
2004
38
t(1;14) and t(11;18) in the differential diagnosis of WaldenstrAPm's macroglobulinemia. (15143341)
2004
39
Use of iodine 131I-tositumomab radioimmunotherapy in a patient with Waldenstrom's macroglobulinemia. (15160923)
2004
40
WaldenstrAPm macroglobulinemia with a novel der(8;17)(q10;q10). (12581904)
2003
41
Preclinical evaluation of 2-[4-(7-chloro-2-quinoxalinyloxy)phenoxy]-propionic acid as a modulator of etoposide in human Waldenstrom's macroglobulinemia xenograft model. (14654565)
2003
42
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
43
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
44
WaldenstrAPm macroglobulinemia-induced bullous dermatosis. (9762027)
1998
45
B-cell lymphoma accompanying monoclonal macroglobulinemia with features suggesting marginal zone B-cell lymphoma. (9195780)
1997
46
A case of mu-heavy chain disease: combined features of mu-chain disease and macroglobulinemia. (9401282)
1997
47
Unusual evolution to immunoblastic lymphoma of a case of WaldenstrAPm macroglobulinemia presenting with thrombocytopenia. (9299877)
1997
48
Anti-interleukin-1 alpha autoantibodies in humans: characterization, isotype distribution, and receptor-binding inhibition--higher frequency in Schnitzler's syndrome (urticaria and macroglobulinemia). (1831824)
1991
49
An unusual case of Hansen's disease (lepromatous leprosy) with circulating anticoagulant and macroglobulinemia. (2119410)
1990
50
An unusual case of WaldenstrAPm macroglobulinemia with half molecules of IgG in serum and urine. (6421347)
1984

Genetic Variations for Macroglobulinemia

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Expression for genes affiliated with Macroglobulinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macroglobulinemia

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Pathways for genes affiliated with Macroglobulinemia

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37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 29KEGG, 51QIAGEN, 12EMD Millipore, 55SinoBiological
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Pathways related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ZAP70, CD40, CD40LG
2
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10.4CD59, CD40LG, CD40
310.4CD40, CD40LG, PTPRC
410.4MAG, MIR206
510.4BIRC3, CD40LG, CD40
610.4ADA, ZAP70, TNFRSF13C
7
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10.4PTPRC, CD40LG, ZAP70, IRF4
810.4MAG, CD40, CD40LG, PTPRC
9
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10.4BIRC3, TNFRSF17, TNFRSF13C
10
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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10.3BIRC3, CD40LG, CD40, TNFRSF17
1110.3CCND1, BIRC3, PAX5, ADA
1210.3TNFRSF13C, ZAP70, CD40, CD40LG, BIRC3
13
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10.3CD40LG, CD40, TNFRSF17, TNFRSF13C, CCND1
14
Hide members
10.3TNFRSF13C, TNFRSF17, CD40, CD40LG, BIRC3
15
Hide members
10.3IRF4, ZAP70, IGHM, CD40, CD40LG, CD59

Compounds for genes affiliated with Macroglobulinemia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1fluorochrome4410.8ZAP70, CD40LG, PTPRC
28-chloroadenosine4410.8CCND1, ADA
3baff2810.8TNFRSF13C, TNFRSF17
4bcma4410.8CD40, TNFRSF17, TNFRSF13C
5blys4410.8TNFRSF13C, TNFRSF17, CD40, CD40LG
6fitc4410.7PTPRC, CD59, ZAP70
7cytidine44 11 2412.7ADA, PAX5, CD40LG, CD40, ZAP70
8ganglioside4410.7MAG, CD40, CD40LG, CD59, PTPRC
9hyaluronic acid44 2411.7HAS1, CD40, CD40LG, PTPRC
10fludarabine44 1111.7ZAP70, CD40, CD40LG, BIRC3, MS4A1, ADA
11formaldehyde44 2411.7PTPRC, CD40LG, ZAP70, CCND1
12paraffin4410.7CCND1, CD40, CD40LG, MS4A1, PAX5, PTPRC
13rituximab44 49 1112.7PAX5, ZAP70, MAG, CD40, CD40LG, CD59
14doxorubicin44 49 1112.7CCND1, CD40, CD40LG, BIRC3, ADA
15genistein44 28 59 2 11 2415.7CCND1, ZAP70, CD40, CD40LG, PTPRC
16serine4410.7CCND1, MAG, BIRC3
17ivig4410.6MAG, CD40, CD40LG
18cyclosporin a44 28 5912.6ADA, PTPRC, CD59, CD40LG, CD40
19neopterin4410.6ADA, CD40LG, CD40
20dexamethasone44 49 28 1113.6ADA, PTPRC, BIRC3, CD40LG, CD40, ZAP70
21phosphatidylinositol4410.6CCND1, ZAP70, CD40, CD59, BIRC3, PTPRC
22n acetylcysteine4410.6CCND1, CD40, CD40LG, PTPRC
23thalidomide44 49 59 1113.6BIRC3, CD40LG, CCND1
24calcium44 49 11 2413.5TNFRSF13C, TNFRSF17, ZAP70, MAG, CD40, CD59
25lipid4410.5ZAP70, MAG, CD40, CD59, BIRC3, MS4A1
26paclitaxel44 49 1112.5CCND1, CD40, BIRC3, ADA
27tyrosine4410.5CCND1, ZAP70, MAG, CD40, CD59, BIRC3
28histamine44 28 2412.5CD40, CD40LG, PTPRC, ADA
29sp 60012544 5911.4BIRC3, CD40, CCND1
30biotin44 11 2412.4ADA, CD40LG, CD40
31tuberculin4410.3CD40LG, ADA
32oligonucleotide4410.3PAX5, BIRC3, CD40, ZAP70, CCND1
33atorvastatin44 49 28 11 2414.1CD59, CD40LG, CD40

GO Terms for genes affiliated with Macroglobulinemia

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16Gene Ontology
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Cellular components related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.2HAS1, ZAP70, IGHM, MAG, CD40, CD40LG
2external side of plasma membraneGO:00989710.0ADA, TNFRSF13C, CD40, CD40LG, MS4A1, PTPRC

Biological processes related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.6CD40, CD40LG, PTPRC
2positive regulation of B cell proliferationGO:03089010.6ADA, PTPRC, CD40, TNFRSF13C
3positive regulation of germinal center formationGO:00263610.6ADA, TNFRSF13C
4T cell activationGO:04211010.5IRF4, ZAP70, ADA
5positive regulation of T cell proliferationGO:04210210.5PTPRC, CD59, TNFRSF13C
6regulation of immunoglobulin secretionGO:05102310.4CD40LG, CD40
7positive regulation of calcium-mediated signalingGO:05085010.4ADA, ZAP70
8positive regulation of endothelial cell apoptotic processGO:200035310.3CD40, CD40LG
9positive regulation of alpha-beta T cell differentiationGO:04663810.1ZAP70, ADA

Products for genes affiliated with Macroglobulinemia

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Sources for Macroglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet