MCID: MCR004
MIFTS: 54

Macroglobulinemia malady

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Summaries for Macroglobulinemia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is... more...

MalaCards: Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to myeloma and cryoglobulinemia. An important gene associated with Macroglobulinemia is MYD88 (myeloid differentiation primary response 88), and among its related pathways are Cytokine production by Th17 cells in CF and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The drugs chlorambucil and cyclophosphamide and the compounds blys and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are respiratory system and normal.

Aliases & Classifications for Macroglobulinemia

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8Disease Ontology, 10DISEASES, 62UMLS, 27ICD9CM, 35MeSH
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Aliases & Descriptions:

macroglobulinemia 8 10
waldenstrom macroglobulinemia 62
primary macroglobulinemia 8


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Disease Ontology8 DOID:9080
ICD9CM27 273.3
MeSH35 D008258

Related Diseases for Macroglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma30.8IRF4, CD40, IGHM, CD40LG
2cryoglobulinemia30.5CD40LG
3leukemia30.5ADA, CD59, ZAP70, CD40LG, CD40, IRF4
4b-cell lymphomas30.5MS4A1, IRF4, IGHM, CD40, ZAP70
5polyneuropathy30.3CD40LG
6autoimmune hemolytic anemia30.2CD40LG, CD59
7hemolytic anemia30.1CD59, ADA
8hairy cell leukemia30.1ADA, CD40
9chronic lymphocytic leukemia30.0MS4A1, CD40LG, CD40, ADA, IGHM, CD59
10malt lymphoma29.9IRF4, IGHM, ZAP70, CD40
11macroglobulinemia, waldenstrom, somatic29.9ADA, IRF4, HAS1, ZAP70, CD40, IGHM
12agammaglobulinemia29.9IGHM, CD40LG
13plasmacytoma29.8IRF4, CD40
14prolymphocytic leukemia29.8ADA, ZAP70
15non-hodgkin lymphoma29.6ADA, IRF4, MS4A1, CD59, CD40
16rheumatoid arthritis29.5HAS1, IGHM, ADA, ZAP70, CD40LG, CD59
17waldenstrom macroglobulinemia10.9
18lymphoplasmacytic lymphoma10.6
19multiple myeloma10.5
20amyloidosis10.4
21neuropathy10.3
22diffuse large b-cell lymphoma10.3
23glomerulonephritis10.2
24hepatitis10.2
25nephrotic syndrome10.2
26splenic marginal zone lymphoma10.2
27marginal zone b-cell lymphoma10.2
28retinitis10.2
29cd40 ligand deficiency10.1CD40LG
30hepatitis c10.1
31mononeuritis multiplex10.1
32mantle cell lymphoma10.1
33mononeuritis10.1
34thrombocytopenia10.1
35splenomegaly10.1
36cryoglobulinemic vasculitis10.1IGHM, CD40LG
37primary immunodeficiency disease10.1CD40, CD40LG
38malignant spiradenoma10.1CD40LG, CD40
39cd40 deficiency10.1CD40, CD40LG
40bruton-type agammaglobulinemia10.1IGHM, CD40
41blood protein disease10.1CD40, CD40LG
42immunodeficiency with hyper igm type 110.1CD40LG, CD40
43immunodeficiency, common variable, 710.0CD40LG, CD40
44common variable immune deficiency10.0CD40LG, CD40
45lupus nephritis10.0CD40LG, CD40
46vasculitis10.0IGHM, CD40LG
47peripheral t-cell lymphoma10.0MS4A1, ZAP70
48influenza10.0ADA, MYD88, HAS1
49lateral sclerosis10.0
50richter's syndrome10.0

Graphical network of the top 20 diseases related to Macroglobulinemia:



Diseases related to macroglobulinemia

Symptoms for Macroglobulinemia

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Drugs & Therapeutics for Macroglobulinemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Macroglobulinemia

Search NIH Clinical Center for Macroglobulinemia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Macroglobulinemia

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Anatomical Context for Macroglobulinemia

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33MalaCards
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MalaCards organs/tissues related to Macroglobulinemia:

33
Bone, Bone marrow, B cells, Liver, Spleen, Lymph node, T cells, Lung, Myeloid, Kidney, Skin, Eye, Heart, Monocytes, Small intestine, Tonsil, Cervix, Ovary, Colon, Breast, Brain, Spinal cord

Animal Models for Macroglobulinemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Macroglobulinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7ZAP70, ADA, MYD88, IGHM
2MP:00028738.0HAS1, IGHM, ADA, ZAP70, CD40
3MP:00053907.8IGHM, MYD88, ADA, ZAP70, CD40LG, CD40
4MP:00053677.7IGHM, MYD88, ADA, CD40LG, CD59, CD40
5MP:00053767.3IGHM, MYD88, ADA, CD40LG, CD59, CD40
6MP:00053877.0IGHM, MYD88, IRF4, ADA, MS4A1, ZAP70
7MP:00053976.2CD40, IGHM, MYD88, IRF4, ADA, MS4A1

Publications for Macroglobulinemia

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52PubMed
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Articles related to Macroglobulinemia:

(show top 50)    (show all 612)
idTitleAuthorsYear
1
Fludarabine in Waldenstrom's macroglobulinemia. (23782076)
2013
2
Waldenstrom macroglobulinemia presenting as isolated persistent epistaxis: a very rare presentation. (24427564)
2013
3
Rituximab Improves Subclinical Temporal Dispersion of Distal Compound Muscle Action Potential in Anti-MAG/SGPG Neuropathy Associated with WaldenstrAPm Macroglobulinemia: A Case Report. (23525653)
2013
4
Immunoglobulin M concentration in WaldenstrAPm macroglobulinemia: correlation with bone marrow B cells and plasma cells. (23523273)
2013
5
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms. (23355535)
2013
6
A single-arm, phase II study of the anti-Blys monoclonal antibody belimumab in symptomatic Waldenstrom macroglobulinemia. (23773449)
2013
7
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
8
Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenstrom macroglobulinemia. (22896002)
2012
9
The Case a8L Hyperbicarbonatemia in a patient with Waldenstrom's macroglobulinemia. Pseudohyperbicarbonatemia due to paraproteinemia. (22373713)
2012
10
WaldenstrAPm's macroglobulinemia-associated renal amyloidosis presenting as a solitary lung mass. (22950818)
2012
11
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. (22976953)
2012
12
Anti-angiogenic therapies in the treatment of Waldenstrom's Macroglobulinemia. (21933107)
2011
13
Development of diffuse large B-cell lymphoma in a patient with WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. (22184531)
2011
14
Pathogenesis and morbidity of autoantibody syndromes in Waldenstrom's macroglobulinemia. (21454221)
2011
15
IgM monoclonal gammopathy of undetermined significance (MGUS) and smoldering WaldenstrAPm's macroglobulinemia (SWM). (21454195)
2011
16
Hepcidin is produced by lymphoplasmacytic cells and is associated with anemia in WaldenstrAPm's macroglobulinemia. (21454222)
2011
17
Expression of CCL3 by neoplastic cells in patients with WaldenstrAPm's macroglobulinemia: an immunohistochemical study in bone marrow biopsies of 67 patients. (21454208)
2011
18
WaldenstrAPm's macroglobulinemia in a dog with a bleeding diathesis. (21827519)
2011
19
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. (19965685)
2010
20
Successful treatment of cryoglobulinemic glomerulonephritis derived from WaldenstrAPm's macroglobulinemia by rituximab-CHOP and tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation. (20686877)
2010
21
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
22
Update on therapeutic options in WaldenstrAPm macroglobulinemia. (19087134)
2009
23
Long-term outcomes to fludarabine and rituximab in WaldenstrAPm macroglobulinemia. (19015393)
2009
24
High-resolution genomic analysis in WaldenstrAPm's macroglobulinemia identifies disease-specific and common abnormalities with marginal zone lymphomas. (19362969)
2009
25
Lumbar spinal nerve root hypertrophy in WaldenstAPm's macroglobulinemia-associated polyneuropathy with antisulphated glucuronyl paragloboside antibody. (19797839)
2009
26
Neurological manifestations of WaldenstrAPm macroglobulinemia. (18813229)
2008
27
Malignant hematopoietic cell lines: in vitro models for the study of WaldenstrAPm's macroglobulinemia. (18533260)
2008
28
SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. (18448868)
2008
29
WSU-WM and BCWM.1 should not be assumed to represent WaldenstrAPm macroglobulinemia cell lines. (18650470)
2008
30
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
31
Recognizing hyperviscosity syndrome in patients with Waldenstrom macroglobulinemia. (17441400)
2007
32
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. (16304043)
2006
33
Advanced WaldenstrAPm's macroglobulinemia: usefulness of Morel's scoring system in establishing prognosis. (15710594)
2005
34
Fludarabine plus cyclophosphamide in WaldenstrAPm's macroglobulinemia: results in 49 patients. (16121217)
2005
35
Analysis of IgH translocations, chromosome 13q14 and 17p13.1(p53) deletions by fluorescence in situ hybridization in Waldenstrom's macroglobulinemia: a single center study of 22 cases. (15103388)
2004
36
Proinflammatory syndrome mimicking acute rheumatoid arthritis in a patient with Waldenstrom's macroglobulinemia treated with rituximab. (14513285)
2004
37
Treatment of Waldenstrom's macroglobulinemia with rituximab: prognostic factors for response and progression. (15370250)
2004
38
Circulating macroglobulinemia cells. (15468987)
2004
39
WaldenstrAPm's macroglobulinemia-associated retinopathy. (15019332)
2004
40
Interstitial deletion of 20q in a patient with WaldenstrAPm macroglobulinemia following chemotherapy. (11850077)
2002
41
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
42
B-chronic lymphocytic leukemia, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma, including WaldenstrAPm's macroglobulinemia: a clinical, morphologic, and biologic spectrum of similar disorders. (10319379)
1999
43
WaldenstrAPm's macroglobulinemia resulting from localized gastric lymphoplasmacytoid lymphoma. (9662279)
1998
44
WaldenstrAPm macroglobulinemia: MR imaging of the spine and CT of the abdomen and pelvis. (8351330)
1993
45
Xanthoma disseminatum and WaldenstrAPm's macroglobulinemia. (2121806)
1990
46
"Supernormal" bone image in a case of WaldenstrAPm macroglobulinemia. (3082557)
1986
47
Remission of acute myelogenous leukemia complicating WaldenstrAPm macroglobulinemia. (102080)
1978
48
Acute myelomonocytic leukemia with macroglobulinemia, Bence Jones proteinuria, and hypercalcemia. (4197775)
1973
49
PRIMARY MACROGLOBULINEMIA: DEATH DUE TO MESENTERIC VASCULAR OCCLUSION WITH GAS IN THE PORTAL VENOUS SYSTEM. (14226112)
1964
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Macroglobulinemia

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Expression for genes affiliated with Macroglobulinemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macroglobulinemia

Search GEO for disease gene expression data for Macroglobulinemia.

Pathways for genes affiliated with Macroglobulinemia

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50PathCards, 60Thomson Reuters, 55Reactome, 38NCBI BioSystems Database, 54R&D Systems, 53QIAGEN, 57SinoBiological, 30KEGG
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Pathways related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IRF4, MYD88
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.6CD40LG, IRF4
39.6CD40LG, IRF4
49.6CD40, CD40LG
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.6CD40LG, CD40
69.6CD40LG, CD40
7
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.3CD59, IGHM
8
Show member pathways
9.3CD40, CD40LG, MYD88
99.3CD40, CD40LG, MYD88
10
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0IRF4, ZAP70, CD40LG
119.0ZAP70, CD40LG, CD40
128.7CD40, CD40LG, ZAP70, MYD88
13
Show member pathways
8.6CD40, CD40LG, ZAP70, IGHM
148.4CD40, CD40LG, ZAP70, ADA

Compounds for genes affiliated with Macroglobulinemia

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45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1blys4510.0CD40LG, CD40
2tuberculin459.9CD40LG, ADA
3ranitidine45 29 24 1112.9CD40LG, ADA
4abciximab45 1110.9CD40LG, CD40
52-chlorodeoxyadenosine459.9ADA, CD40LG
6clopidogrel45 51 24 1112.9CD40, CD40LG
7fluorochrome459.8CD40LG, ZAP70
8okt3459.8CD40LG, ZAP70
9mycophenolate mofetil45 51 1111.8CD40, CD40LG
10galalpha(1,3)gal459.7CD59, CD40LG
11endotoxin459.7MYD88, CD40LG, CD40
12fenofibrate45 51 1111.6CD40, CD40LG
13hyaluronic acid45 2410.6CD40, CD40LG, HAS1
14rantes459.6MYD88, CD40LG, CD40
15ivig459.6CD40LG, CD40
16allergens459.6CD40, CD40LG
17ribavirin45 51 1111.5CD40LG, ADA
18neopterin459.5ADA, CD40LG, CD40
19biotin45 24 1111.5CD40, CD40LG, ADA
20indomethacin45 29 61 1112.4CD40, CD40LG, ADA
21fitc459.3ZAP70, CD59
22paraffin459.3MS4A1, CD40LG, CD40
23histamine45 29 2411.3ADA, CD40LG, CD40
24cyclophosphamide45 51 1111.3CD40, ZAP70, MS4A1
25vitamin b12459.3CD40LG, ADA
26doxorubicin45 51 1111.3CD40, CD40LG, ADA
27ganglioside459.2CD40, CD59, CD40LG
28atorvastatin45 51 29 24 1113.2CD40LG, CD59, CD40
29aspirin45 51 29 2412.1ADA, CD40LG, CD59
30genistein45 29 61 3 24 1114.1CD40, CD40LG, ZAP70
31cytidine45 24 1110.9CD40, CD40LG, ZAP70, ADA
32dexamethasone45 51 29 1111.8CD40, CD40LG, ZAP70, ADA
33cyclosporin a45 29 6110.6ADA, CD40LG, CD59, CD40
34phosphatidylinositol458.5CD40, CD59, ZAP70, MYD88
35lactate458.5ADA, ZAP70, CD40LG, CD59
36fludarabine45 51 1110.5CD40, CD40LG, ZAP70, MS4A1, ADA
37oxygen45 249.4CD40, CD59, ZAP70, MYD88
38atp45 299.4MYD88, ADA, ZAP70, CD59
39lipid458.2CD40, CD59, ZAP70, MS4A1, MYD88
40rituximab45 51 1110.2MS4A1, ZAP70, CD40LG, CD59, CD40

GO Terms for genes affiliated with Macroglobulinemia

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16Gene Ontology
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Cellular components related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.8CD59, ADA, IGHM
2external side of plasma membraneGO:0098978.7CD40, CD40LG, MS4A1, ADA
3integral component of plasma membraneGO:0058878.6CD40, CD40LG, MS4A1, HAS1
4extracellular spaceGO:0056157.7ADA, MS4A1, CD40LG, CD59, CD40
5plasma membraneGO:0058866.6HAS1, IGHM, MYD88, ADA, ZAP70, CD40LG

Biological processes related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:0510239.8CD40LG, CD40
2positive regulation of endothelial cell apoptotic processGO:20003539.7CD40, CD40LG
3cellular response to mechanical stimulusGO:0712609.7CD40, MYD88
4positive regulation of interleukin-12 productionGO:0327359.6CD40, CD40LG
5positive regulation of alpha-beta T cell differentiationGO:0466389.5ZAP70, ADA
6positive regulation of calcium-mediated signalingGO:0508509.4ADA, ZAP70
7positive regulation of B cell proliferationGO:0308909.4CD40, ADA
8B cell proliferationGO:0421009.4CD40, CD40LG, MS4A1
9adaptive immune responseGO:0022509.4IGHM, ZAP70
10T cell activationGO:0421109.1ZAP70, ADA, IRF4
11inflammatory responseGO:0069549.0CD40, CD40LG, MYD88

Molecular functions related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:0038239.6CD40, IGHM

Products for genes affiliated with Macroglobulinemia

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  • Antibodies
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Sources for Macroglobulinemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet