MCID: MCR004
MIFTS: 54

Macroglobulinemia malady

Summaries for Macroglobulinemia

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64Wikipedia, 33MalaCards
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Wikipedia:64 Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is... more...

MalaCards: Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to macroglobulinemia, waldenstrom, somatic and acute leukemia. An important gene associated with Macroglobulinemia is HAS1 (hyaluronan synthase 1), and among its related pathways are Inflammatory Response Pathway and Classical antibody-mediated complement activation. The drugs cyclophosphamide and thalidomide and the compounds fluorochrome and 8-chloroadenosine have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Macroglobulinemia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 27ICD9CM
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Aliases & Descriptions:

macroglobulinemia 8 10
waldenstrom macroglobulinemia 61
primary macroglobulinemia 8


External Ids:

Disease Ontology8 DOID:9080
MeSH35 D008258
ICD9CM27 273.3

Related Diseases for Macroglobulinemia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1macroglobulinemia, waldenstrom, somatic30.5IRF4, CCND1, HAS1, ZAP70, ADA, PTPRC
2acute leukemia30.5BIRC3, PAX5, PTPRC
3lymphoma, diffuse large cell30.4MS4A1, PAX5, PTPRC
4cryoglobulinemia30.3CD40LG
5plasma cell leukemia30.1CCND1, CD40
6arthritis29.8CD59
7hepatitis c29.8IGHM, CD40LG, PAX5
8agammaglobulinemia29.8CD40LG, IGHM
9t-cell leukemia29.8IRF4, ZAP70, CD40, BIRC3, PTPRC, ADA
10chronic myeloid leukemia29.8IRF4, CD59, BIRC3, PTPRC, ADA
11waldenstrom macroglobulinemia11.0
12lymphoplasmacytic lymphoma10.6
13amyloidosis10.4
14n syndrome10.3
15splenic marginal zone lymphoma10.2
16macroglobulinemia, waldenstrom 110.2
17autoimmune hemolytic anemia10.2
18mononeuritis multiplex10.1
19gastric lymphoma10.1
20mantle cell lymphoma10.1
21thrombocytopenia10.1
22splenomegaly10.1
23lymphoma, somatic10.1
24lymphoplasmacytoid lymphoma10.1
25membranoproliferative glomerulonephritis10.0
26richter's syndrome10.0
27lateral sclerosis10.0
28schnitzler syndrome10.0
29peliosis hepatis10.0
30fanconi syndrome10.0
31central retinal vein occlusion10.0
32amyotrophic lateral sclerosis10.0
33acute myelomonocytic leukemia10.0
34cold agglutinin disease10.0
35cytomegalic inclusion disease10.0
36nodular regenerative hyperplasia10.0
37macroglobulinemia, waldenstrom 210.0
38lupus erythematosus10.0CD40LG
39asthma10.0ZAP70
40primary immunodeficiency disease10.0CD40, CD40LG
41hypersensitivity reaction type ii disease10.0CD40
42myasthenia gravis10.0MAG
43lung cancer10.0CCND1
44multiple myeloma10.0CD40, IRF4, CCND1
45myeloid leukemia10.0PTPRC
46common variable immune deficiency10.0CD40LG, CD40, TNFRSF13C
47hepatitis10.0CD40LG
48sjogren's syndrome10.0CD40LG, CD40
49anaplastic large cell lymphoma10.0PTPRC, PAX5, ZAP70
50malignant spiradenoma10.0CD40LG, CD40

Graphical network of the top 20 diseases related to Macroglobulinemia:



Diseases related to macroglobulinemia

Clinical Features for Macroglobulinemia

Drugs & Therapeutics for Macroglobulinemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Macroglobulinemia

Drug clinical trials:

Search ClinicalTrials for Macroglobulinemia

Search NIH Clinical Center for Macroglobulinemia

Search CenterWatch for Macroglobulinemia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Macroglobulinemia

Anatomical Context for Macroglobulinemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Macroglobulinemia:

33
Skin, Ovary, Liver, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Heart, Skeletal muscle, Small intestine, Colon, Breast, Cervix, Tonsil, Myeloid, Monocytes, T cells, B lymphoblasts, B cells

Animal Models for Macroglobulinemia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Macroglobulinemia

Sources:
51PubMed
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Articles related to Macroglobulinemia:

(show top 50)    (show all 620)
idTitleAuthorsYear
1
WaldenstrAPm macroglobulinemia: from biology to treatment. (24405328)
2014
2
Genetic factors and pathogenesis of WaldenstrAPm's macroglobulinemia. (23901022)
2013
3
Radiographic findings in WaldenstrAPm's macroglobulinemia resembling fibrogenesis imperfecta ossium (FIO): A case report. (24072255)
2013
4
Histidine based adsorbents for selective removal of monoclonal immunoglobulin IgM antibodies from Waldenstrom's macroglobulinemia patient sera: a preliminary study. (23811496)
2013
5
Absence of BRAF exon 15 mutations in multiple myeloma and WaldenstrAPm's macroglobulinemia questions its validity as a therapeutic target in plasma cell neoplasias. (23675568)
2013
6
Waldenstrom macroglobulinemia with a durable clinical response to epoetin beta. (22260157)
2012
7
Second malignancies among Waldenstrom macroglobulinemia patients: small samples and sparse data. (22100692)
2012
8
Risk of second cancers in WaldenstrAPm macroglobulinemia. (21525403)
2012
9
WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma, version 2.2013. (23054875)
2012
10
New insights into the pathogenesis and treatment of Waldenstrom macroglobulinemia. (21519243)
2011
11
The role of 18F-FDG PET/CT imaging in Waldenstrom macroglobulinemia. (21681781)
2011
12
Establishment and characterization of a novel Waldenstrom macroglobulinemia cell line, MWCL-1. (21415268)
2011
13
Multifocal osteomyelitis with Streptococcus pneumoniae in a patient with WaldenstrAPm macroglobulinemia: a case report. (21543667)
2011
14
WaldenstrAPm macroglobulinemia with pseudo-Gaucher cells. (21089228)
2010
15
Phase II trial of weekly bortezomib in combination with rituximab in untreated patients with WaldenstrAPm Macroglobulinemia. (20652865)
2010
16
New Therapeutic Approaches for Waldenstrom Macroglobulinemia. (21869855)
2010
17
Rituximab-induced life-threatening coagulopathy occurring in a patient with WaldenstrAPm macroglobulinemia treated with fludarabine, cyclophosphamide, and rituximab combination. (20929331)
2010
18
Waldenstrom's macroglobulinemia: Recent advances in biology and therapy. (20040909)
2009
19
Distal renal tubular acidosis in lymphoplasmacytic lymphoma WaldenstrAPm's macroglobulinemia: a case report. (19829932)
2009
20
How I treat WaldenstrAPm macroglobulinemia. (19617573)
2009
21
Increased incidence of transformation and myelodysplasia/acute leukemia in patients with WaldenstrAPm macroglobulinemia treated with nucleoside analogs. (19064987)
2009
22
Long-term survival in Waldenstrom macroglobulinemia: 10-year follow-up of Southwest Oncology Group-directed intergroup trial S9003. (18931340)
2009
23
WSU-WM and BCWM.1 should not be assumed to represent WaldenstrAPm macroglobulinemia cell lines. (18650470)
2008
24
Durable remission of large B-cell lymphoma transformed from lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia successfully treated with sequential immunochemotherapy followed by reduced-intensity allogeneic stem cell transplantation. (18071292)
2008
25
Development of EBV-associated diffuse large B-cell lymphoma in Waldenstrom macroglobulinemia and mantle cell lymphoma. (18608870)
2008
26
WaldenstrAPm macroglobulinemia of the orbit. (18209658)
2008
27
Effect of chemotherapy schedule on response in WaldenstrAPm's macroglobulinemia in a dog. (18289314)
2008
28
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
29
Primary treatment of WaldenstrAPm macroglobulinemia with dexamethasone, rituximab, and cyclophosphamide. (17577016)
2007
30
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. (16304043)
2006
31
Nuclear BCL-10 expression is common in lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia and does not correlate with p65 NF-kappaB activation. (16636680)
2006
32
WaldenstrAPm macroglobulinemia: a review of therapy. (15929102)
2005
33
How we treat WaldenstrAPm's macroglobulinemia. (15642678)
2005
34
Analysis of IgH translocations, chromosome 13q14 and 17p13.1(p53) deletions by fluorescence in situ hybridization in Waldenstrom's macroglobulinemia: a single center study of 22 cases. (15103388)
2004
35
Circulating macroglobulinemia cells. (15468987)
2004
36
The international staging system for multiple myeloma is applicable in symptomatic Waldenstrom's macroglobulinemia. (15223640)
2004
37
WaldenstrAPm's macroglobulinemia: prognostic factors and recent therapeutic advances. (15103509)
2004
38
Use of fludarabine in the treatment of mantle cell lymphoma, WaldenstrAPm's macroglobulinemia and other uncommon B- and T-cell lymphoid malignancies. (15079153)
2004
39
Occurrence of acute monocytic leukemia in a case of untreated WaldenstrAPm's macroglobulinemia. (12353307)
2002
40
WaldenstrAPm macroglobulinemia caused by extranodal marginal zone B-cell lymphoma: a report of six cases. (11710684)
2001
41
Evaluating treatment strategies in advanced WaldenstrAPm macroglobulinemia: use of quality-adjusted survival analysis. (11516109)
2001
42
Clonal evolution in Waldenstrom macroglobulinemia highlights functional role of B-cell receptor. (11133777)
2001
43
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
44
WaldenstrAPm macroglobulinemia-induced bullous dermatosis. (9762027)
1998
45
B-cell lymphoma accompanying monoclonal macroglobulinemia with features suggesting marginal zone B-cell lymphoma. (9195780)
1997
46
A case of mu-heavy chain disease: combined features of mu-chain disease and macroglobulinemia. (9401282)
1997
47
Frequent somatic mutations in D and/or JH segments of Ig gene in WaldenstrAPm's macroglobulinemia and chronic lymphocytic leukemia (CLL) with Richter's syndrome but not in common CLL. (7703494)
1995
48
An unusual case of Hansen's disease (lepromatous leprosy) with circulating anticoagulant and macroglobulinemia. (2119410)
1990
49
Sequential development of WaldenstrAPm's macroglobulinemia and gamma-1-heavy chain disease in a single patient. Clinical, immunochemical, immunofluorescent and protein studies. (6419527)
1984
50
Cold agglutinin disease. A type of primary macroglobulinemia: a new concept. (14492540)
1962

Genetic Variations for Macroglobulinemia

Expression for genes affiliated with Macroglobulinemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macroglobulinemia

Search GEO for disease gene expression data for Macroglobulinemia.

Pathways for genes affiliated with Macroglobulinemia

Sources:
38NCBI BioSystems Database, 54Reactome, 53R&D Systems, 30KEGG, 52QIAGEN, 12EMD Millipore, 56SinoBiological
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Pathways related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ZAP70, CD40, CD40LG
2
Hide members
10.4CD59, CD40LG, CD40
310.4CD40, CD40LG, PTPRC
410.4MAG, MIR206
510.4BIRC3, CD40LG, CD40
610.4ADA, ZAP70, TNFRSF13C
7
Hide members
10.4PTPRC, CD40LG, ZAP70, IRF4
810.4MAG, CD40, CD40LG, PTPRC
9
Hide members
10.4BIRC3, TNFRSF17, TNFRSF13C
10
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
Hide members
10.3BIRC3, CD40LG, CD40, TNFRSF17
1110.3CCND1, BIRC3, PAX5, ADA
1210.3TNFRSF13C, ZAP70, CD40, CD40LG, BIRC3
13
Hide members
10.3CD40LG, CD40, TNFRSF17, TNFRSF13C, CCND1
14
Hide members
10.3TNFRSF13C, TNFRSF17, CD40, CD40LG, BIRC3
15
Hide members
10.3IRF4, ZAP70, IGHM, CD40, CD40LG, CD59

Compounds for genes affiliated with Macroglobulinemia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1fluorochrome4510.8ZAP70, CD40LG, PTPRC
28-chloroadenosine4510.8CCND1, ADA
3baff2910.8TNFRSF13C, TNFRSF17
4bcma4510.8CD40, TNFRSF17, TNFRSF13C
5blys4510.8TNFRSF13C, TNFRSF17, CD40, CD40LG
6fitc4510.7PTPRC, CD59, ZAP70
7cytidine45 11 2412.7ADA, PAX5, CD40LG, CD40, ZAP70
8ganglioside4510.7MAG, CD40, CD40LG, CD59, PTPRC
9hyaluronic acid45 2411.7HAS1, CD40, CD40LG, PTPRC
10fludarabine45 1111.7ZAP70, CD40, CD40LG, BIRC3, MS4A1, ADA
11formaldehyde45 2411.7PTPRC, CD40LG, ZAP70, CCND1
12paraffin4510.7CCND1, CD40, CD40LG, MS4A1, PAX5, PTPRC
13rituximab45 50 1112.7PAX5, ZAP70, MAG, CD40, CD40LG, CD59
14doxorubicin45 50 1112.7CCND1, CD40, CD40LG, BIRC3, ADA
15genistein45 29 60 2 11 2415.7CCND1, ZAP70, CD40, CD40LG, PTPRC
16serine4510.7CCND1, MAG, BIRC3
17ivig4510.6MAG, CD40, CD40LG
18cyclosporin a45 29 6012.6ADA, PTPRC, CD59, CD40LG, CD40
19neopterin4510.6ADA, CD40LG, CD40
20dexamethasone45 50 29 1113.6ADA, PTPRC, BIRC3, CD40LG, CD40, ZAP70
21phosphatidylinositol4510.6CCND1, ZAP70, CD40, CD59, BIRC3, PTPRC
22n acetylcysteine4510.6CCND1, CD40, CD40LG, PTPRC
23thalidomide45 50 60 1113.6BIRC3, CD40LG, CCND1
24calcium45 50 11 2413.5TNFRSF13C, TNFRSF17, ZAP70, MAG, CD40, CD59
25lipid4510.5ZAP70, MAG, CD40, CD59, BIRC3, MS4A1
26paclitaxel45 50 1112.5CCND1, CD40, BIRC3, ADA
27tyrosine4510.5CCND1, ZAP70, MAG, CD40, CD59, BIRC3
28histamine45 29 2412.5CD40, CD40LG, PTPRC, ADA
29sp 60012545 6011.4BIRC3, CD40, CCND1
30biotin45 11 2412.4ADA, CD40LG, CD40
31tuberculin4510.3CD40LG, ADA
32oligonucleotide4510.3PAX5, BIRC3, CD40, ZAP70, CCND1
33atorvastatin45 50 29 11 2414.1CD59, CD40LG, CD40

GO Terms for genes affiliated with Macroglobulinemia

Sources:
16Gene Ontology
See all sources

Cellular components related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.2HAS1, ZAP70, IGHM, MAG, CD40, CD40LG
2external side of plasma membraneGO:00989710.0ADA, TNFRSF13C, CD40, CD40LG, MS4A1, PTPRC

Biological processes related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.6CD40, CD40LG, PTPRC
2positive regulation of B cell proliferationGO:03089010.6ADA, PTPRC, CD40, TNFRSF13C
3positive regulation of germinal center formationGO:00263610.6ADA, TNFRSF13C
4T cell activationGO:04211010.5IRF4, ZAP70, ADA
5positive regulation of T cell proliferationGO:04210210.5PTPRC, CD59, TNFRSF13C
6regulation of immunoglobulin secretionGO:05102310.4CD40LG, CD40
7positive regulation of calcium-mediated signalingGO:05085010.4ADA, ZAP70
8positive regulation of endothelial cell apoptotic processGO:200035310.3CD40, CD40LG
9positive regulation of alpha-beta T cell differentiationGO:04663810.1ZAP70, ADA

Products for genes affiliated with Macroglobulinemia

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  • Proteins
  • Lysates
  • Antibodies

Sources for Macroglobulinemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet