MCID: MCR004
MIFTS: 55

Macroglobulinemia malady

Summaries for Macroglobulinemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is... more...

MalaCards: Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to myeloma and multiple myeloma. An important gene associated with Macroglobulinemia is HAS1 (hyaluronan synthase 1), and among its related pathways are Inflammatory Response Pathway and Classical antibody-mediated complement activation. The drugs chlorambucil and cyclophosphamide and the compounds fluorochrome and 8-chloroadenosine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Macroglobulinemia

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

macroglobulinemia 8 10
waldenstrom macroglobulinemia 60
primary macroglobulinemia 8


External Ids:

Disease Ontology8 DOID:9080
MeSH34 D008258
ICD9CM27 273.3

Related Diseases for Macroglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma30.8PTPRC, PAX5, BIRC3, CD40LG, CD40, MAG
2multiple myeloma30.7CD40, IRF4, CCND1
3leukemia30.7CCND1, IRF4, ZAP70, CD40, CD40LG, CD59
4acute leukemia30.4BIRC3, PAX5, PTPRC
5macroglobulinemia, waldenstrom, somatic30.3IRF4, CCND1, HAS1, ZAP70, ADA, PTPRC
6cryoglobulinemia30.3CD40LG
7chronic lymphocytic leukemia30.3TNFRSF17, TNFRSF13C, CCND1, ADA, PTPRC, PAX5
8hepatitis30.2CD40LG
9hepatitis c30.1IGHM, CD40LG, PAX5
10myeloid leukemia29.9PTPRC
11hairy cell leukemia29.9CCND1, CD40, PTPRC, ADA
12lupus erythematosus29.7CD40LG
13arthritis29.7CD59
14hepatitis b29.7IGHM
15plasmacytoma29.7PTPRC, PAX5, CD40, IRF4
16prolymphocytic leukemia29.7CCND1, ZAP70, ADA
17multiple sclerosis29.7TNFRSF13C, TNFRSF17, MAG, CD40, CD59, PTPRC
18agammaglobulinemia29.7CD40LG, IGHM
19chronic myeloid leukemia29.7IRF4, CD59, BIRC3, PTPRC, ADA
20proteinuria29.7CD59, CD40LG
21rheumatoid arthritis29.7TNFRSF13C, TNFRSF17, HAS1, ZAP70, IGHM, CD40
22non-hodgkin lymphoma29.7CCND1, TNFRSF13C, ADA, PTPRC, PAX5, MS4A1
23breast cancer29.7ADA, BIRC3, CD59, CD40, HAS1, CCND1
24hematologic cancer29.7ADA, PAX5, ZAP70
25lymphoplasmacytic lymphoma10.6
26waldenstrom macroglobulinemia10.4
27amyloidosis10.3
28neuropathy10.3
29diffuse large b-cell lymphoma10.2
30splenic marginal zone lymphoma10.2
31glomerulonephritis10.2
32marginal zone b-cell lymphoma10.2
33nephrotic syndrome10.2
34autoimmune hemolytic anemia10.1
35hemolytic anemia10.1
36retinitis10.1
37mononeuritis multiplex10.1
38gastric lymphoma10.1
39mantle cell lymphoma10.1
40mononeuritis10.1
41polyneuropathy10.1
42thrombocytopenia10.1
43asthma10.0ZAP70
44hypersensitivity reaction type ii disease10.0CD40
45primary immunodeficiency disease10.0CD40, CD40LG
46myasthenia gravis10.0MAG
47lung cancer10.0CCND1
48plasma cell leukemia10.0CCND1, CD40
49common variable immune deficiency10.0CD40LG, CD40, TNFRSF13C
50sjogren's syndrome10.0CD40LG, CD40

Graphical network of the top 20 diseases related to Macroglobulinemia:



Diseases related to macroglobulinemia

Clinical Features for Macroglobulinemia

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Drugs & Therapeutics for Macroglobulinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Macroglobulinemia

Drug clinical trials:

Search ClinicalTrials for Macroglobulinemia

Search NIH Clinical Center for Macroglobulinemia

Search CenterWatch for Macroglobulinemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Macroglobulinemia

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Anatomical Context for Macroglobulinemia

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32MalaCards
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MalaCards organs/tissues related to Macroglobulinemia:

32
Bone, Bone marrow, B cells, Liver, Spleen, Lymph node, T cells, Lung, Myeloid, Kidney, Skin, Eye, Heart, Monocytes, Small intestine, Tonsil, Cervix, Ovary, Colon, Breast, Brain, Spinal cord

Animal Models for Macroglobulinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Macroglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4CD59, IGHM
2MP:000539710.2ADA, CCND1, TNFRSF13C, TNFRSF17, IRF4, ZAP70
3MP:000538710.2ZAP70, IRF4, TNFRSF17, TNFRSF13C, CCND1, IGHM
4MP:000538410.1IGHM, ZAP70, IRF4, TNFRSF13C, CCND1, CD40
5MP:000287310.1CCND1, TNFRSF17, HAS1, ZAP70, IGHM, CD40
6MP:000539010.0CCND1, IGHM, CD40, CD40LG, PAX5, PTPRC

Publications for Macroglobulinemia

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50PubMed
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Articles related to Macroglobulinemia:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Nuclear protein dysregulation in lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia. (23355206)
2013
2
Etiology of WaldenstrAPm macroglobulinemia: genetic factors and immune-related conditions. (23473950)
2013
3
Unique association of WaldenstrAPm macroglobulinemia with optic neuritis and monoclonal T cell expansion. (23743950)
2013
4
The bone marrow microenvironment in WaldenstrAPm macroglobulinemia. (23490994)
2013
5
What is WaldenstrAPm macroglobulinemia? (23772642)
2013
6
A new era for Waldenstrom macroglobulinemia: MYD88 L265P. (23723443)
2013
7
IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and WaldenstrAPm macroglobulinemia/lymphoplasmacytic lymphomas. (22944768)
2013
8
WaldenstrAPm macroglobulinemia. (22507796)
2012
9
MYD88 L265P somatic mutation in WaldenstrAPm's macroglobulinemia. (22931316)
2012
10
Expression of CCL3 by neoplastic cells in patients with WaldenstrAPm's macroglobulinemia: an immunohistochemical study in bone marrow biopsies of 67 patients. (21454208)
2011
11
WaldenstrAPm's macroglobulinemia in a dog with a bleeding diathesis. (21827519)
2011
12
Histone deacetylase inhibitors demonstrate significant preclinical activity as single agents, and in combination with bortezomib in WaldenstrAPm's macroglobulinemia. (21454220)
2011
13
Bilateral ocular involvement as a presentation of WaldenstrAPm's macroglobulinemia. (20697839)
2011
14
Peripheral capillary non-perfusion in asymptomatic WaldenstrAPm's macroglobulinemia. (21126377)
2010
15
Update on therapeutic options in WaldenstrAPm macroglobulinemia. (19087134)
2009
16
High-dose therapy with autologous PBSC transplantation in the front-line treatment of Waldenstrom's macroglobulinemia. (18978819)
2009
17
Novel aspects pertaining to the relationship of WaldenstrAPm's macroglobulinemia, IgM monoclonal gammopathy of undetermined significance, polyclonal gammopathy, and hypoglobulinemia. (19362963)
2009
18
Prognostication in young and old patients with WaldenstrAPm's macroglobulinemia: importance of the International Prognostic Scoring System and of serum lactate dehydrogenase. (19362972)
2009
19
Effect of plasmapheresis on hyperviscosity-related retinopathy and retinal hemodynamics in patients with Waldenstrom's macroglobulinemia. (18326744)
2008
20
The IL6(-174G/C) polymorphism is a prognostic factor for survival after treatment initiation in Waldenstrom macroglobulinemia patients aged 65 years or less. (18508793)
2008
21
Gangrenous, hemorrhagic, bullous cellulitis associated with pseudomonas aeruginosa in a patient with WaldenstrAPm's macroglobulinemia. (17721738)
2007
22
Establishment of BCWM.1 cell line for WaldenstrAPm's macroglobulinemia with productive in vivo engraftment in SCID-hu mice. (17761288)
2007
23
Lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia with inv(16)(p13q22) as a sole genetic abnormality. (17452259)
2007
24
Genomics and proteomics in multiple myeloma and WaldenstrAPm macroglobulinemia. (17534163)
2007
25
6q deletion discriminates WaldenstrAPm macroglobulinemia from IgM monoclonal gammopathy of undetermined significance. (16938573)
2006
26
Clinical and immunological worsening in a patient affected with Waldenstrom macroglobulinemia and anti-mag neuropathy after treatment with rituximab. (16785123)
2006
27
Fanconi's syndrome induced by a monoclonal Vkappa3 light chain in Waldenstrom's macroglobulinemia. (15806478)
2005
28
Rarity of IgH translocations in WaldenstrAPm macroglobulinemia. (16271961)
2005
29
Pulmonary non-caseating granuloma in WaldenstrAPm macroglobulinemia. (16146205)
2005
30
Lymphoplasmacytic lymphoma/waldenstrom macroglobulinemia: an evolving concept. (16210920)
2005
31
Durable complete remission after chemotherapy and rituximab in a case of WaldenstrAPm's macroglobulinemia with pleuropulmonary involvement. (15915349)
2005
32
Proinflammatory syndrome mimicking acute rheumatoid arthritis in a patient with Waldenstrom's macroglobulinemia treated with rituximab. (14513285)
2004
33
WaldenstrAPm's macroglobulinemia-associated retinopathy. (15019332)
2004
34
Waldenstrom's macroglobulinemia of the GI tract. (15164728)
2004
35
XK469, a topo IIbeta inhibitor, induces apoptosis in Waldenstrom's macroglobulinemia through multiple pathways. (14612935)
2003
36
Simultaneous occurrence of polycythemia vera and Waldenstrom macroglobulinemia: a case report and review of the literature. (12243551)
2002
37
Lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia associated with Hodgkin disease. A report of two cases. (11447749)
2001
38
Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for WaldenstrAPm's macroglobulinemia with severe pancytopenia. (11607775)
2001
39
Rearrangement of immunoglobulin gene in metastatic WaldenstrAPm macroglobulinemia to the vitreous. (10704566)
2000
40
Concomitant partial tetrasomy 3q and trisomy 18 in WaldenstrAPm macroglobulinemia. (7773966)
1995
41
2Chlorodeoxyadenosine therapy of patients with WaldenstrAPm macroglobulinemia previously treated with fludarabine. (7514439)
1994
42
Peripheral neuropathy in IgM monoclonal gammopathy and WAoldenstrom's macroglobulinemia: a frequent complication in elderly males with low MAG-reactive serum monoclonal component. (7504399)
1994
43
Transitions in CD45 isoform expression indicate continuous differentiation of a monoclonal CD5+ CD11b+ B lineage in Waldenstrom's macroglobulinemia. (1708944)
1991
44
Diffuse large cell lymphoma occurring in a patient with WaldenstrAPm's macroglobulinemia. Evidence for the two different clones in Richter's syndrome. (1906774)
1991
45
Anti-platelet and anti-DNA IgM in WaldenstrAPm macroglobulinemia and ITP. (3105305)
1987
46
Mononeuritis multiplex in WaldenstrAPm's macroglobulinemia. (3116914)
1987
47
T-cell subpopulations in patients with monoclonal gammopathies: essential monoclonal gammopathy, multiple myeloma, and Waldenstrom macroglobulinemia. (3933332)
1985
48
WaldenstrAPm's macroglobulinemia and mononeuritis multiplex. (415654)
1978
49
The fibrinolytic system in human blood, as exemplified in a case of agammaglobulinemia and a case of macroglobulinemia. (13794906)
1960
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Genetic Variations for Macroglobulinemia

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Expression for genes affiliated with Macroglobulinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macroglobulinemia

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Pathways for genes affiliated with Macroglobulinemia

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37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 29KEGG, 51QIAGEN, 12EMD Millipore, 55SinoBiological
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Pathways related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ZAP70, CD40, CD40LG
2
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10.4CD59, CD40LG, CD40
310.4CD40, CD40LG, PTPRC
410.4MAG, MIR206
510.4BIRC3, CD40LG, CD40
610.4ADA, ZAP70, TNFRSF13C
7
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10.4PTPRC, CD40LG, ZAP70, IRF4
810.4MAG, CD40, CD40LG, PTPRC
9
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10.4BIRC3, TNFRSF17, TNFRSF13C
10
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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10.3BIRC3, CD40LG, CD40, TNFRSF17
1110.3CCND1, BIRC3, PAX5, ADA
1210.3TNFRSF13C, ZAP70, CD40, CD40LG, BIRC3
13
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10.3CD40LG, CD40, TNFRSF17, TNFRSF13C, CCND1
14
Hide members
10.3TNFRSF13C, TNFRSF17, CD40, CD40LG, BIRC3
15
Hide members
10.3IRF4, ZAP70, IGHM, CD40, CD40LG, CD59

Compounds for genes affiliated with Macroglobulinemia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1fluorochrome4410.8ZAP70, CD40LG, PTPRC
28-chloroadenosine4410.8CCND1, ADA
3baff2810.8TNFRSF13C, TNFRSF17
4bcma4410.8CD40, TNFRSF17, TNFRSF13C
5blys4410.8TNFRSF13C, TNFRSF17, CD40, CD40LG
6fitc4410.7PTPRC, CD59, ZAP70
7cytidine44 11 2412.7ADA, PAX5, CD40LG, CD40, ZAP70
8ganglioside4410.7MAG, CD40, CD40LG, CD59, PTPRC
9hyaluronic acid44 2411.7HAS1, CD40, CD40LG, PTPRC
10fludarabine44 1111.7ZAP70, CD40, CD40LG, BIRC3, MS4A1, ADA
11formaldehyde44 2411.7PTPRC, CD40LG, ZAP70, CCND1
12paraffin4410.7CCND1, CD40, CD40LG, MS4A1, PAX5, PTPRC
13rituximab44 49 1112.7PAX5, ZAP70, MAG, CD40, CD40LG, CD59
14doxorubicin44 49 1112.7CCND1, CD40, CD40LG, BIRC3, ADA
15genistein44 28 59 2 11 2415.7CCND1, ZAP70, CD40, CD40LG, PTPRC
16serine4410.7CCND1, MAG, BIRC3
17ivig4410.6MAG, CD40, CD40LG
18cyclosporin a44 28 5912.6ADA, PTPRC, CD59, CD40LG, CD40
19neopterin4410.6ADA, CD40LG, CD40
20dexamethasone44 49 28 1113.6ADA, PTPRC, BIRC3, CD40LG, CD40, ZAP70
21phosphatidylinositol4410.6CCND1, ZAP70, CD40, CD59, BIRC3, PTPRC
22n acetylcysteine4410.6CCND1, CD40, CD40LG, PTPRC
23thalidomide44 49 59 1113.6BIRC3, CD40LG, CCND1
24calcium44 49 11 2413.5TNFRSF13C, TNFRSF17, ZAP70, MAG, CD40, CD59
25lipid4410.5ZAP70, MAG, CD40, CD59, BIRC3, MS4A1
26paclitaxel44 49 1112.5CCND1, CD40, BIRC3, ADA
27tyrosine4410.5CCND1, ZAP70, MAG, CD40, CD59, BIRC3
28histamine44 28 2412.5CD40, CD40LG, PTPRC, ADA
29sp 60012544 5911.4BIRC3, CD40, CCND1
30biotin44 11 2412.4ADA, CD40LG, CD40
31tuberculin4410.3CD40LG, ADA
32oligonucleotide4410.3PAX5, BIRC3, CD40, ZAP70, CCND1
33atorvastatin44 49 28 11 2414.1CD59, CD40LG, CD40

GO Terms for genes affiliated with Macroglobulinemia

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16Gene Ontology
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Cellular components related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.2HAS1, ZAP70, IGHM, MAG, CD40, CD40LG
2external side of plasma membraneGO:00989710.0ADA, TNFRSF13C, CD40, CD40LG, MS4A1, PTPRC

Biological processes related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.6CD40, CD40LG, PTPRC
2positive regulation of B cell proliferationGO:03089010.6ADA, PTPRC, CD40, TNFRSF13C
3positive regulation of germinal center formationGO:00263610.6ADA, TNFRSF13C
4T cell activationGO:04211010.5IRF4, ZAP70, ADA
5positive regulation of T cell proliferationGO:04210210.5PTPRC, CD59, TNFRSF13C
6regulation of immunoglobulin secretionGO:05102310.4CD40LG, CD40
7positive regulation of calcium-mediated signalingGO:05085010.4ADA, ZAP70
8positive regulation of endothelial cell apoptotic processGO:200035310.3CD40, CD40LG
9positive regulation of alpha-beta T cell differentiationGO:04663810.1ZAP70, ADA

Products for genes affiliated with Macroglobulinemia

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Sources for Macroglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet