MCID: MCR004
MIFTS: 53

Macroglobulinemia malady

Summaries for Macroglobulinemia

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Wikipedia:65 Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is... more...

MalaCards based summary: Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to waldenstrom macroglobulinemia and myeloma. An important gene associated with Macroglobulinemia is MYD88 (myeloid differentiation primary response 88), and among its related pathways are Cytokine production by Th17 cells in CF and Calcineurin-regulated NFAT-dependent transcription in lymphocytes. The drugs cyclophosphamide and thalidomide and the compounds blys and tuberculin have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are respiratory system and normal.

Aliases & Classifications for Macroglobulinemia

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Macroglobulinemia, Aliases & Descriptions:

Name: Macroglobulinemia 10 12
Waldenstrom Macroglobulinemia 62
 
Primary Macroglobulinemia 10


External Ids:

Disease Ontology10 DOID:9080
MeSH35 D008258
ICD9CM29 273.3

Related Diseases for Macroglobulinemia

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Diseases related to Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1waldenstrom macroglobulinemia31.1ADA, IRF4, HAS1, ZAP70, CD40, IGHM
2myeloma30.9IRF4, CD40, IGHM, CD40LG
3leukemia30.6ADA, CD59, ZAP70, CD40LG, CD40, IRF4
4b-cell lymphomas30.5MS4A1, IRF4, IGHM, CD40, ZAP70
5cryoglobulinemia30.5CD40LG
6polyneuropathy30.3CD40LG
7chronic lymphocytic leukemia30.3MS4A1, CD40LG, ZAP70, IGHM, CD40
8autoimmune hemolytic anemia30.3CD40LG, CD59
9hemolytic anemia30.3CD59, ADA
10malt lymphoma30.1IRF4, IGHM, ZAP70, CD40
11hodgkin lymphoma30.0ZAP70, IRF4, IGHM, MS4A1, CD40
12agammaglobulinemia29.9IGHM, CD40LG
13plasmacytoma29.8IRF4, CD40
14prolymphocytic leukemia29.8ADA, ZAP70
15rheumatoid arthritis29.6HAS1, IGHM, ADA, ZAP70, CD40LG, CD59
16lymphoplasmacytic lymphoma10.7
17multiple myeloma10.5
18amyloidosis10.4
19macroglobulinemia, waldenstrom, somatic10.3
20neuropathy10.3
21diffuse large b-cell lymphoma10.3
22hepatitis10.3
23glomerulonephritis10.2
24splenic marginal zone lymphoma10.2
25nephrotic syndrome10.2
26marginal zone b-cell lymphoma10.2
27thrombocytopenia10.2
28hepatitis c10.2
29retinitis10.2
30mantle cell lymphoma10.1
31mononeuritis multiplex10.1
32schnitzler syndrome10.1
33mononeuritis10.1
34splenomegaly10.1
35x-linked hyper igm syndrome10.1CD40LG
36cryoglobulinemia, familial mixed10.0IGHM, CD40LG
37hepatitis c virus10.0
38acute leukemia10.0
39retinal vein occlusion10.0
40lateral sclerosis10.0
41richter's syndrome10.0
42pure red-cell aplasia10.0
43membranoproliferative glomerulonephritis10.0
44peliosis hepatis10.0
45central retinal vein occlusion10.0
46lymphoblastic leukemia10.0
47peripheral neuropathy10.0
48pneumonia10.0
49acute myelomonocytic leukemia10.0
50al amyloidosis10.0

Graphical network of the top 20 diseases related to Macroglobulinemia:



Diseases related to macroglobulinemia

Symptoms for Macroglobulinemia

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Drugs & Therapeutics for Macroglobulinemia

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Drug clinical trials:

Search ClinicalTrials for Macroglobulinemia

Search NIH Clinical Center for Macroglobulinemia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Macroglobulinemia

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Anatomical Context for Macroglobulinemia

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MalaCards organs/tissues related to Macroglobulinemia:

33
Bone, Bone marrow, B cells, Liver, Spleen, Lymph node, T cells, Kidney, Lung, Myeloid, Brain, Colon, Skin, Eye, Spinal cord, Heart, Small intestine, Breast, Ovary, Cervix, Tonsil, Monocytes

Animal Models for Macroglobulinemia or affiliated genes

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MGI Mouse Phenotypes related to Macroglobulinemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.7ZAP70, ADA, MYD88, IGHM
2MP:00028738.0HAS1, IGHM, ADA, ZAP70, CD40
3MP:00053907.8IGHM, MYD88, ADA, ZAP70, CD40LG, CD40
4MP:00053677.7IGHM, MYD88, ADA, CD40LG, CD59, CD40
5MP:00053767.3IGHM, MYD88, ADA, CD40LG, CD59, CD40
6MP:00053877.0IGHM, MYD88, IRF4, ADA, MS4A1, ZAP70
7MP:00053976.2CD40, IGHM, MYD88, IRF4, ADA, MS4A1

Publications for Macroglobulinemia

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Articles related to Macroglobulinemia:

(show top 50)    (show all 672)
idTitleAuthorsYear
1
WaldenstrAPm's macroglobulinemia: The role of hospital transfusion medicine laboratory in the diagnosis and management. (25722563)
2015
2
Bevacizumab therapy and multimodal ultrawide-field imaging in immunogammopathy maculopathy secondary to WaldenstrAPm's macroglobulinemia. (25707055)
2015
3
Interstitial pulmonary amyloidosis with WaldenstrAPm's macroglobulinemia. (25748748)
2015
4
Biology, prognosis, and therapy of WaldenstrAPm Macroglobulinemia. (25655610)
2015
5
Population-based study on the impact of the familial form of WaldenstrAPm macroglobulinemia on overall survival. (25814489)
2015
6
Interstitial pneumonitis related to rituximab therapy for WaldenstrAPm's macroglobulinemia. (25798285)
2015
7
Extramedullary WaldenstrAPm Macroglobulinemia. (25349134)
2014
8
Treatment recommendations for patients with WaldenstrAPm macroglobulinemia (WM) and related disorders: IWWM-7 consensus. (25027391)
2014
9
Fludarabine in Waldenstrom's macroglobulinemia. (23782076)
2013
10
Waldenstrom macroglobulinemia presenting as isolated persistent epistaxis: a very rare presentation. (24427564)
2013
11
Rituximab Improves Subclinical Temporal Dispersion of Distal Compound Muscle Action Potential in Anti-MAG/SGPG Neuropathy Associated with WaldenstrAPm Macroglobulinemia: A Case Report. (23525653)
2013
12
Immunoglobulin M concentration in WaldenstrAPm macroglobulinemia: correlation with bone marrow B cells and plasma cells. (23523273)
2013
13
Prevalence and clinical significance of the MYD88 (L265P) somatic mutation in Waldenstrom's macroglobulinemia and related lymphoid neoplasms. (23355535)
2013
14
Tonsil amyloidosis revealing a WaldenstrAPm macroglobulinemia. (22197994)
2012
15
Clinical and prognostic implications of low or high level of von Willebrand factor in patients with Waldenstrom macroglobulinemia. (22896002)
2012
16
The Case a8L Hyperbicarbonatemia in a patient with Waldenstrom's macroglobulinemia. Pseudohyperbicarbonatemia due to paraproteinemia. (22373713)
2012
17
WaldenstrAPm's macroglobulinemia-associated renal amyloidosis presenting as a solitary lung mass. (22950818)
2012
18
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia. (22976953)
2012
19
Anti-angiogenic therapies in the treatment of Waldenstrom's Macroglobulinemia. (21933107)
2011
20
Development of diffuse large B-cell lymphoma in a patient with WaldenstrAPm's macroglobulinemia/lymphoplasmacytic lymphoma: clonal identity between two B-cell neoplasms. (22184531)
2011
21
Pathogenesis and morbidity of autoantibody syndromes in Waldenstrom's macroglobulinemia. (21454221)
2011
22
IgM monoclonal gammopathy of undetermined significance (MGUS) and smoldering WaldenstrAPm's macroglobulinemia (SWM). (21454195)
2011
23
Hepcidin is produced by lymphoplasmacytic cells and is associated with anemia in WaldenstrAPm's macroglobulinemia. (21454222)
2011
24
Expression of CCL3 by neoplastic cells in patients with WaldenstrAPm's macroglobulinemia: an immunohistochemical study in bone marrow biopsies of 67 patients. (21454208)
2011
25
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. (19965685)
2010
26
Successful treatment of cryoglobulinemic glomerulonephritis derived from WaldenstrAPm's macroglobulinemia by rituximab-CHOP and tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation. (20686877)
2010
27
Cold agglutinin-mediated autoimmune hemolytic anemia in WaldenstrAPm's macroglobulinemia. (19362990)
2009
28
Update on therapeutic options in WaldenstrAPm macroglobulinemia. (19087134)
2009
29
Long-term outcomes to fludarabine and rituximab in WaldenstrAPm macroglobulinemia. (19015393)
2009
30
Neurological manifestations of WaldenstrAPm macroglobulinemia. (18813229)
2008
31
Malignant hematopoietic cell lines: in vitro models for the study of WaldenstrAPm's macroglobulinemia. (18533260)
2008
32
SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom macroglobulinemia. (18448868)
2008
33
WSU-WM and BCWM.1 should not be assumed to represent WaldenstrAPm macroglobulinemia cell lines. (18650470)
2008
34
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
35
Recognizing hyperviscosity syndrome in patients with Waldenstrom macroglobulinemia. (17441400)
2007
36
B-lymphocyte stimulator (BLyS) stimulates immunoglobulin production and malignant B-cell growth in Waldenstrom macroglobulinemia. (16304043)
2006
37
Fludarabine plus cyclophosphamide in WaldenstrAPm's macroglobulinemia: results in 49 patients. (16121217)
2005
38
Proinflammatory syndrome mimicking acute rheumatoid arthritis in a patient with Waldenstrom's macroglobulinemia treated with rituximab. (14513285)
2004
39
Treatment of Waldenstrom's macroglobulinemia with rituximab: prognostic factors for response and progression. (15370250)
2004
40
Circulating macroglobulinemia cells. (15468987)
2004
41
WaldenstrAPm's macroglobulinemia-associated retinopathy. (15019332)
2004
42
Interstitial deletion of 20q in a patient with WaldenstrAPm macroglobulinemia following chemotherapy. (11850077)
2002
43
The tyranny of the anecdote: Waldenstrom's macroglobulinemia and scleritis. (10980683)
2000
44
B-chronic lymphocytic leukemia, small lymphocytic lymphoma, and lymphoplasmacytic lymphoma, including WaldenstrAPm's macroglobulinemia: a clinical, morphologic, and biologic spectrum of similar disorders. (10319379)
1999
45
WaldenstrAPm's macroglobulinemia resulting from localized gastric lymphoplasmacytoid lymphoma. (9662279)
1998
46
Xanthoma disseminatum and WaldenstrAPm's macroglobulinemia. (2121806)
1990
47
"Supernormal" bone image in a case of WaldenstrAPm macroglobulinemia. (3082557)
1986
48
Remission of acute myelogenous leukemia complicating WaldenstrAPm macroglobulinemia. (102080)
1978
49
PRIMARY MACROGLOBULINEMIA: DEATH DUE TO MESENTERIC VASCULAR OCCLUSION WITH GAS IN THE PORTAL VENOUS SYSTEM. (14226112)
1964
50
Cryoglobulinemia, macroglobulinemia, and the aminoaciduria which is sometimes associated with multiple myeloma. (13307228)
1956

Variations for Macroglobulinemia

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Expression for genes affiliated with Macroglobulinemia

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Search GEO for disease gene expression data for Macroglobulinemia.

Pathways for genes affiliated with Macroglobulinemia

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Pathways related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7IRF4, MYD88
2
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
9.6CD40LG, IRF4
39.6CD40LG, IRF4
49.6CD40, CD40LG
5
Show member pathways
Apoptosis and survival Anti apoptotic TNFs NF kB IAP pathway60
9.6CD40LG, CD40
69.6CD40LG, CD40
7
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.3CD59, IGHM
8
Show member pathways
9.3CD40, CD40LG, MYD88
99.3CD40, CD40LG, MYD88
10
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.0IRF4, ZAP70, CD40LG
119.0ZAP70, CD40LG, CD40
128.7CD40, CD40LG, ZAP70, MYD88
13
Show member pathways
8.6CD40, CD40LG, ZAP70, IGHM
148.4CD40, CD40LG, ZAP70, ADA

Compounds for genes affiliated with Macroglobulinemia

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Compounds related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1blys4510.0CD40LG, CD40
2tuberculin459.9CD40LG, ADA
3ranitidine45 30 26 1312.9CD40LG, ADA
4abciximab45 1310.9CD40LG, CD40
52-chlorodeoxyadenosine459.9ADA, CD40LG
6clopidogrel45 51 26 1312.9CD40, CD40LG
7fluorochrome459.8CD40LG, ZAP70
8okt3459.8CD40LG, ZAP70
9mycophenolate mofetil45 51 1311.8CD40, CD40LG
10galalpha(1,3)gal459.7CD59, CD40LG
11endotoxin459.7MYD88, CD40LG, CD40
12fenofibrate45 51 1311.6CD40, CD40LG
13hyaluronic acid45 2610.6CD40, CD40LG, HAS1
14rantes459.6MYD88, CD40LG, CD40
15ivig459.6CD40LG, CD40
16allergens459.6CD40, CD40LG
17ribavirin45 51 1311.5CD40LG, ADA
18neopterin459.5ADA, CD40LG, CD40
19biotin45 26 1311.5CD40, CD40LG, ADA
20indomethacin45 30 61 1312.4CD40, CD40LG, ADA
21fitc459.3ZAP70, CD59
22paraffin459.3MS4A1, CD40LG, CD40
23histamine45 30 2611.3ADA, CD40LG, CD40
24cyclophosphamide45 51 1311.3CD40, ZAP70, MS4A1
25vitamin b12459.3CD40LG, ADA
26doxorubicin45 51 1311.3CD40, CD40LG, ADA
27ganglioside459.2CD40, CD59, CD40LG
28atorvastatin45 51 30 26 1313.2CD40LG, CD59, CD40
29aspirin45 51 30 2612.1ADA, CD40LG, CD59
30genistein45 30 61 3 26 1314.1CD40, CD40LG, ZAP70
31cytidine45 26 1310.9CD40, CD40LG, ZAP70, ADA
32dexamethasone45 51 30 1311.8CD40, CD40LG, ZAP70, ADA
33cyclosporin a45 30 6110.6ADA, CD40LG, CD59, CD40
34phosphatidylinositol458.5CD40, CD59, ZAP70, MYD88
35lactate458.5ADA, ZAP70, CD40LG, CD59
36fludarabine45 51 1310.5CD40, CD40LG, ZAP70, MS4A1, ADA
37oxygen45 269.4CD40, CD59, ZAP70, MYD88
38atp45 309.4MYD88, ADA, ZAP70, CD59
39lipid458.2CD40, CD59, ZAP70, MS4A1, MYD88
40rituximab45 51 1310.2MS4A1, ZAP70, CD40LG, CD59, CD40

GO Terms for genes affiliated with Macroglobulinemia

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Cellular components related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.8CD59, ADA, IGHM
2external side of plasma membraneGO:00098978.7CD40, CD40LG, MS4A1, ADA
3integral component of plasma membraneGO:00058878.6CD40, CD40LG, MS4A1, HAS1
4extracellular spaceGO:00056157.7ADA, MS4A1, CD40LG, CD59, CD40
5plasma membraneGO:00058866.6HAS1, IGHM, MYD88, ADA, ZAP70, CD40LG

Biological processes related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1regulation of immunoglobulin secretionGO:00510239.8CD40LG, CD40
2positive regulation of endothelial cell apoptotic processGO:020003539.7CD40, CD40LG
3cellular response to mechanical stimulusGO:00712609.7CD40, MYD88
4positive regulation of interleukin-12 productionGO:00327359.6CD40, CD40LG
5positive regulation of alpha-beta T cell differentiationGO:00466389.5ZAP70, ADA
6positive regulation of calcium-mediated signalingGO:00508509.4ADA, ZAP70
7positive regulation of B cell proliferationGO:00308909.4CD40, ADA
8B cell proliferationGO:00421009.4CD40, CD40LG, MS4A1
9adaptive immune responseGO:00022509.4IGHM, ZAP70
10T cell activationGO:00421109.1ZAP70, ADA, IRF4
11inflammatory responseGO:00069549.0CD40, CD40LG, MYD88

Molecular functions related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1antigen bindingGO:00038239.6CD40, IGHM

Products for genes affiliated with Macroglobulinemia

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Sources for Macroglobulinemia

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet