MCID: MCR004
MIFTS: 55

Macroglobulinemia malady

Summaries for Macroglobulinemia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. It is... more...

MalaCards: Macroglobulinemia, also known as waldenstrom macroglobulinemia, is related to myeloma and multiple myeloma. An important gene associated with Macroglobulinemia is HAS1 (hyaluronan synthase 1), and among its related pathways are Inflammatory Response Pathway and Classical antibody-mediated complement activation. The drugs chlorambucil and cyclophosphamide and the compounds fluorochrome and 8-chloroadenosine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Macroglobulinemia

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

macroglobulinemia 8 10
waldenstrom macroglobulinemia 60
primary macroglobulinemia 8


External Ids:

Disease Ontology8 DOID:9080
MeSH34 D008258
ICD9CM27 273.3

Related Diseases for Macroglobulinemia

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17GeneCards, 18GeneDecks
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Diseases related to Macroglobulinemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1myeloma30.8PTPRC, PAX5, BIRC3, CD40LG, CD40, MAG
2multiple myeloma30.7CD40, IRF4, CCND1
3leukemia30.7CCND1, IRF4, ZAP70, CD40, CD40LG, CD59
4acute leukemia30.4BIRC3, PAX5, PTPRC
5macroglobulinemia, waldenstrom, somatic30.3IRF4, CCND1, HAS1, ZAP70, ADA, PTPRC
6cryoglobulinemia30.3CD40LG
7chronic lymphocytic leukemia30.3TNFRSF17, TNFRSF13C, CCND1, ADA, PTPRC, PAX5
8hepatitis30.2CD40LG
9hepatitis c30.1IGHM, CD40LG, PAX5
10myeloid leukemia29.9PTPRC
11hairy cell leukemia29.9CCND1, CD40, PTPRC, ADA
12lupus erythematosus29.7CD40LG
13arthritis29.7CD59
14hepatitis b29.7IGHM
15plasmacytoma29.7PTPRC, PAX5, CD40, IRF4
16prolymphocytic leukemia29.7CCND1, ZAP70, ADA
17multiple sclerosis29.7TNFRSF13C, TNFRSF17, MAG, CD40, CD59, PTPRC
18agammaglobulinemia29.7CD40LG, IGHM
19chronic myeloid leukemia29.7IRF4, CD59, BIRC3, PTPRC, ADA
20proteinuria29.7CD59, CD40LG
21rheumatoid arthritis29.7TNFRSF13C, TNFRSF17, HAS1, ZAP70, IGHM, CD40
22non-hodgkin lymphoma29.7CCND1, TNFRSF13C, ADA, PTPRC, PAX5, MS4A1
23breast cancer29.7ADA, BIRC3, CD59, CD40, HAS1, CCND1
24hematologic cancer29.7ADA, PAX5, ZAP70
25lymphoplasmacytic lymphoma10.6
26waldenstrom macroglobulinemia10.4
27amyloidosis10.3
28neuropathy10.3
29diffuse large b-cell lymphoma10.2
30splenic marginal zone lymphoma10.2
31glomerulonephritis10.2
32marginal zone b-cell lymphoma10.2
33nephrotic syndrome10.2
34autoimmune hemolytic anemia10.1
35hemolytic anemia10.1
36retinitis10.1
37mononeuritis multiplex10.1
38gastric lymphoma10.1
39mantle cell lymphoma10.1
40mononeuritis10.1
41polyneuropathy10.1
42thrombocytopenia10.1
43asthma10.0ZAP70
44hypersensitivity reaction type ii disease10.0CD40
45primary immunodeficiency disease10.0CD40, CD40LG
46myasthenia gravis10.0MAG
47lung cancer10.0CCND1
48plasma cell leukemia10.0CCND1, CD40
49common variable immune deficiency10.0CD40LG, CD40, TNFRSF13C
50sjogren's syndrome10.0CD40LG, CD40

Graphical network of the top 20 diseases related to Macroglobulinemia:



Diseases related to macroglobulinemia

Clinical Features for Macroglobulinemia

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Drugs & Therapeutics for Macroglobulinemia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Macroglobulinemia

Drug clinical trials:

Search ClinicalTrials for Macroglobulinemia

Search NIH Clinical Center for Macroglobulinemia

Search CenterWatch for Macroglobulinemia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Macroglobulinemia

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Anatomical Context for Macroglobulinemia

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32MalaCards
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MalaCards organs/tissues related to Macroglobulinemia:

32
Bone, Bone marrow, B cells, Liver, Spleen, Lymph node, T cells, Lung, Myeloid, Kidney, Skin, Eye, Heart, Monocytes, Small intestine, Tonsil, Cervix, Ovary, Colon, Breast, Brain, Spinal cord

Animal Models for Macroglobulinemia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Macroglobulinemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536710.4CD59, IGHM
2MP:000539710.2ADA, CCND1, TNFRSF13C, TNFRSF17, IRF4, ZAP70
3MP:000538710.2ZAP70, IRF4, TNFRSF17, TNFRSF13C, CCND1, IGHM
4MP:000538410.1IGHM, ZAP70, IRF4, TNFRSF13C, CCND1, CD40
5MP:000287310.1CCND1, TNFRSF17, HAS1, ZAP70, IGHM, CD40
6MP:000539010.0CCND1, IGHM, CD40, CD40LG, PAX5, PTPRC

Publications for Macroglobulinemia

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50PubMed
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Articles related to Macroglobulinemia:

(show top 50)    (show all 619)
idTitleAuthorsYear
1
Fludarabine in Waldenstrom's macroglobulinemia. (23782076)
2013
2
Rituximab Improves Subclinical Temporal Dispersion of Distal Compound Muscle Action Potential in Anti-MAG/SGPG Neuropathy Associated with WaldenstrAPm Macroglobulinemia: A Case Report. (23525653)
2013
3
Immunoglobulin M concentration in WaldenstrAPm macroglobulinemia: correlation with bone marrow B cells and plasma cells. (23523273)
2013
4
A single-arm, phase II study of the anti-Blys monoclonal antibody belimumab in symptomatic Waldenstrom macroglobulinemia. (23773449)
2013
5
WaldenstrAPm macroglobulinemia with cryoglobulinemia revealed by amorphous deposits on blood smear. (23893295)
2013
6
Effective treatment of WaldenstrAPm macroglobulinemia associated pure red cell aplasia with standard antilymphomatous chemotherapy. (23841509)
2013
7
WaldenstrAPm macroglobulinemia: a review of the entity and its differential diagnosis. (22156831)
2012
8
Excellent long-term survival of 170 patients with WaldenstrAPm's macroglobulinemia treated in private oncology practices and a university hospital. (22895554)
2012
9
Mechanisms of activity of the TORC1 inhibitor everolimus in Waldenstrom macroglobulinemia. (23048077)
2012
10
Anti-angiogenic therapies in the treatment of Waldenstrom's Macroglobulinemia. (21933107)
2011
11
Hyperphosphorylated paratarg-7: a new molecularly defined risk factor for monoclonal gammopathy of undetermined significance of the IgM type and Waldenstrom macroglobulinemia. (21220746)
2011
12
Distinctive clinical and histological features of WaldenstrAPm's macroglobulinemia and splenic marginal zone lymphoma. (21454204)
2011
13
Novel M-component based biomarkers in WaldenstrAPm's macroglobulinemia. (21454223)
2011
14
Phase I study of atacicept in relapsed/refractory multiple myeloma (MM) and WaldenstrAPm's macroglobulinemia. (21454215)
2011
15
Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia. (19965685)
2010
16
AA amyloidosis associated with macroglobulinemia. (20953745)
2010
17
Review of clinical trials conducted in Waldenstrom macroglobulinemia and recommendations for reporting clinical trial responses in these patients. (20795787)
2010
18
Novel agents in Waldenstrom Macroglobulinemia. (22844582)
2010
19
Epigenetic modifications as key regulators of Waldenstrom's Macroglobulinemia biology. (20929526)
2010
20
Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia. (20103671)
2010
21
Progressive multifocal leukoencephalopathy with occult WaldenstrAPm macroglobulinemia. (20855833)
2010
22
Lymphoplasmacytic lymphoma with Waldenstrom's macroglobulinemia as a reason for peripheral arterial perfusion disorders. (19588311)
2009
23
WaldenstrAPm's macroglobulinemia in a 10-year stable IgG monoclonal gammopathy of undetermined significance. (18455789)
2009
24
Novel antibody-based therapeutic agents targeting CD70: a potential approach for treating WaldenstrAPm's macroglobulinemia. (19362984)
2009
25
Individualizing treatment for Waldenstrom's macroglobulinemia. (21083011)
2009
26
Endoplasmic reticulum stress is a target for therapy in Waldenstrom macroglobulinemia. (18981296)
2009
27
Proceedings of the 5th International Workshop on WaldenstrAPm's Macroglobulinemia. October 15-19, 2008. Stockholm, Sweden. (19362960)
2009
28
Multicenter clinical trial of bortezomib in relapsed/refractory Waldenstrom's macroglobulinemia: results of WMCTG Trial 03-248. (17545538)
2007
29
CD5, CD10, and CD23 expression in Waldenstrom's macroglobulinemia. (15794857)
2005
30
Clinicopathologic features of Waldenstrom's macroglobulinemia and marginal zone lymphoma: are they distinct or the same entity? (15794852)
2005
31
Different biological behaviour of WaldenstrAPm Macroglobulinemia in two dogs. (19379217)
2005
32
Bilateral orbital tumor formation and isolated facial palsy in Waldenstrom's macroglobulinemia. (17356930)
2005
33
Differential diagnosis of Waldenstrom's macroglobulinemia and other B-cell disorders. (15794855)
2005
34
Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia. (15794859)
2005
35
Primary lung involvement with amyloid deposition in WaldenstAPm's macroglobulinemia: observations from over 20 years. (15497253)
2004
36
Multicenter phase 2 trial of rituximab for WaldenstrAPm macroglobulinemia (WM): an Eastern Cooperative Oncology Group Study (E3A98). (15370249)
2004
37
Initial immunoglobulin M 'flare' after rituximab therapy in patients diagnosed with Waldenstrom macroglobulinemia: an Eastern Cooperative Oncology Group Study. (15493038)
2004
38
Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome. (15526921)
2004
39
Diffuse large B-cell lymphoma occurring in patients with lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia. Clinicopathologic features of 12 cases. (12931555)
2003
40
Novel biologically based therapies for Waldenstrom's macroglobulinemia. (12720159)
2003
41
Cutaneous lymphoplasmacytoid lymphoma (immunocytoma) with WaldenstrAPm's macroglobulinemia mimicking rosacea. (14639408)
2003
42
Cytogenetic findings in lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia. Chromosomal abnormalities are associated with the polymorphous subtype and an aggressive clinical course. (11601139)
2001
43
Association between motoneuron disease and WaldenstrAPm macroglobulinemia]. (11552308)
2001
44
Lymphoplasmacytic lymphoma/WaldenstrAPm macroglobulinemia: one disease or three? (11764065)
2001
45
WaldenstrAPm macroglobulinemia: MR imaging of the spine and CT of the abdomen and pelvis. (8351330)
1993
46
Peliosis hepatis, nodular regenerative hyperplasia of the liver, and light-chain deposition in a patient with WaldenstrAPm's macroglobulinemia. (3134270)
1988
47
Pulmonary manifestations of Waldenstrom macroglobulinemia. (6776807)
1980
48
Multiple myeloma and WaldenstrAPm macroglobulinemia: unusual presentations. (6767276)
1980
49
Monoclonal macroglobulinemia and cytomegalic inclusion disease. (4350589)
1973
50
Waldenstrom macroglobulinemia. (13698157)
1961

Genetic Variations for Macroglobulinemia

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Expression for genes affiliated with Macroglobulinemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macroglobulinemia

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Pathways for genes affiliated with Macroglobulinemia

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37NCBI BioSystems Database, 53Reactome, 52R&D Systems, 29KEGG, 51QIAGEN, 12EMD Millipore, 55SinoBiological
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Pathways related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4ZAP70, CD40, CD40LG
2
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10.4CD59, CD40LG, CD40
310.4CD40, CD40LG, PTPRC
410.4MAG, MIR206
510.4BIRC3, CD40LG, CD40
610.4ADA, ZAP70, TNFRSF13C
7
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10.4PTPRC, CD40LG, ZAP70, IRF4
810.4MAG, CD40, CD40LG, PTPRC
9
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10.4BIRC3, TNFRSF17, TNFRSF13C
10
Apoptosis and survival Anti-apoptotic TNFs/NF-kB/Bcl-2 pathway
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10.3BIRC3, CD40LG, CD40, TNFRSF17
1110.3CCND1, BIRC3, PAX5, ADA
1210.3TNFRSF13C, ZAP70, CD40, CD40LG, BIRC3
13
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10.3CD40LG, CD40, TNFRSF17, TNFRSF13C, CCND1
14
Hide members
10.3TNFRSF13C, TNFRSF17, CD40, CD40LG, BIRC3
15
Hide members
10.3IRF4, ZAP70, IGHM, CD40, CD40LG, CD59

Compounds for genes affiliated with Macroglobulinemia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1fluorochrome4410.8ZAP70, CD40LG, PTPRC
28-chloroadenosine4410.8CCND1, ADA
3baff2810.8TNFRSF13C, TNFRSF17
4bcma4410.8CD40, TNFRSF17, TNFRSF13C
5blys4410.8TNFRSF13C, TNFRSF17, CD40, CD40LG
6fitc4410.7PTPRC, CD59, ZAP70
7cytidine44 11 2412.7ADA, PAX5, CD40LG, CD40, ZAP70
8ganglioside4410.7MAG, CD40, CD40LG, CD59, PTPRC
9hyaluronic acid44 2411.7HAS1, CD40, CD40LG, PTPRC
10fludarabine44 1111.7ZAP70, CD40, CD40LG, BIRC3, MS4A1, ADA
11formaldehyde44 2411.7PTPRC, CD40LG, ZAP70, CCND1
12paraffin4410.7CCND1, CD40, CD40LG, MS4A1, PAX5, PTPRC
13rituximab44 49 1112.7PAX5, ZAP70, MAG, CD40, CD40LG, CD59
14doxorubicin44 49 1112.7CCND1, CD40, CD40LG, BIRC3, ADA
15genistein44 28 59 2 11 2415.7CCND1, ZAP70, CD40, CD40LG, PTPRC
16serine4410.7CCND1, MAG, BIRC3
17ivig4410.6MAG, CD40, CD40LG
18cyclosporin a44 28 5912.6ADA, PTPRC, CD59, CD40LG, CD40
19neopterin4410.6ADA, CD40LG, CD40
20dexamethasone44 49 28 1113.6ADA, PTPRC, BIRC3, CD40LG, CD40, ZAP70
21phosphatidylinositol4410.6CCND1, ZAP70, CD40, CD59, BIRC3, PTPRC
22n acetylcysteine4410.6CCND1, CD40, CD40LG, PTPRC
23thalidomide44 49 59 1113.6BIRC3, CD40LG, CCND1
24calcium44 49 11 2413.5TNFRSF13C, TNFRSF17, ZAP70, MAG, CD40, CD59
25lipid4410.5ZAP70, MAG, CD40, CD59, BIRC3, MS4A1
26paclitaxel44 49 1112.5CCND1, CD40, BIRC3, ADA
27tyrosine4410.5CCND1, ZAP70, MAG, CD40, CD59, BIRC3
28histamine44 28 2412.5CD40, CD40LG, PTPRC, ADA
29sp 60012544 5911.4BIRC3, CD40, CCND1
30biotin44 11 2412.4ADA, CD40LG, CD40
31tuberculin4410.3CD40LG, ADA
32oligonucleotide4410.3PAX5, BIRC3, CD40, ZAP70, CCND1
33atorvastatin44 49 28 11 2414.1CD59, CD40LG, CD40

GO Terms for genes affiliated with Macroglobulinemia

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16Gene Ontology
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Cellular components related to Macroglobulinemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588610.2HAS1, ZAP70, IGHM, MAG, CD40, CD40LG
2external side of plasma membraneGO:00989710.0ADA, TNFRSF13C, CD40, CD40LG, MS4A1, PTPRC

Biological processes related to Macroglobulinemia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1B cell proliferationGO:04210010.6CD40, CD40LG, PTPRC
2positive regulation of B cell proliferationGO:03089010.6ADA, PTPRC, CD40, TNFRSF13C
3positive regulation of germinal center formationGO:00263610.6ADA, TNFRSF13C
4T cell activationGO:04211010.5IRF4, ZAP70, ADA
5positive regulation of T cell proliferationGO:04210210.5PTPRC, CD59, TNFRSF13C
6regulation of immunoglobulin secretionGO:05102310.4CD40LG, CD40
7positive regulation of calcium-mediated signalingGO:05085010.4ADA, ZAP70
8positive regulation of endothelial cell apoptotic processGO:200035310.3CD40, CD40LG
9positive regulation of alpha-beta T cell differentiationGO:04663810.1ZAP70, ADA

Products for genes affiliated with Macroglobulinemia

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Sources for Macroglobulinemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet