MCID: MCR161
MIFTS: 19

Macroglobulinemia, Waldenstrom 1

Categories: Rare diseases, Blood diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Macroglobulinemia, Waldenstrom 1

MalaCards integrated aliases for Macroglobulinemia, Waldenstrom 1:

Name: Macroglobulinemia, Waldenstrom 1 53
Macroglobulinemia, Waldenstrom, Susceptibility to, 1 53 13
Wm1 53

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant


HPO:

31
macroglobulinemia, waldenstrom 1:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Macroglobulinemia, Waldenstrom 1

OMIM : 53 Waldenstrom macroglobulinemia (WM) is a malignant B-cell neoplasm characterized by lymphoplasmacytic infiltration of the bone marrow and hypersecretion of monoclonal immunoglobulin M (IgM) protein (review by Vijay and Gertz, 2007). The importance of genetic factors is suggested by the observation of familial clustering of WM (McMaster, 2003). Whereas WM is rare, an asymptomatic elevation of monoclonal IgM protein, termed 'IgM monoclonal gammopathy of undetermined significance' (IgM MGUS) is more common. Patients with IgM MGUS can progress to develop WM, at the rate of 1.5% to 2% per year (Kyle et al., 2003). (153600)

MalaCards based summary : Macroglobulinemia, Waldenstrom 1, also known as macroglobulinemia, waldenstrom, susceptibility to, 1, is related to waldenstrom macroglobulinemia, and has symptoms including lymphoma, polyneuropathy and polyclonal elevation of igm. An important gene associated with Macroglobulinemia, Waldenstrom 1 is WM1 (Macroglobulinemia, Waldenstrom, Susceptibility To, 1). The drugs Chlorambucil and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and b cells.

Related Diseases for Macroglobulinemia, Waldenstrom 1

Diseases in the Waldenstrom Macroglobulinemia family:

Macroglobulinemia, Waldenstrom 1 Macroglobulinemia, Waldenstrom 2

Diseases related to Macroglobulinemia, Waldenstrom 1 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 waldenstrom macroglobulinemia 10.9

Symptoms & Phenotypes for Macroglobulinemia, Waldenstrom 1

Symptoms via clinical synopsis from OMIM:

53
Heme:
waldenstrom macroglobulinemia

Neuro:
polyneuropathy

Oncology:
increased frequency of lymphoma, leukemia, and adenocarcinom of lung

Lab:
impaired lymphocyte transformation with phytohemagglutinin
polyclonal elevation of igm


Clinical features from OMIM:

153600

Human phenotypes related to Macroglobulinemia, Waldenstrom 1:

31 (show all 6)
# Description HPO Frequency HPO Source Accession
1 lymphoma 31 occasional (7.5%) HP:0002665
2 polyneuropathy 31 HP:0001271
3 polyclonal elevation of igm 31 HP:0003459
4 leukemia 31 occasional (7.5%) HP:0001909
5 impaired lymphocyte transformation with phytohemagglutinin 31 HP:0003347
6 monoclonal immunoglobulin m proteinemia 31 HP:0005508

Drugs & Therapeutics for Macroglobulinemia, Waldenstrom 1

Drugs for Macroglobulinemia, Waldenstrom 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorambucil Approved Phase 3 305-03-3 2708
2
Fludarabine Approved Phase 3 21679-14-1, 75607-67-9 30751
3
Vidarabine Approved, Investigational Phase 3 24356-66-9 21704 32326
4 Alkylating Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Antimetabolites Phase 3
7 Antimetabolites, Antineoplastic Phase 3
8 Antiviral Agents Phase 3
9 Immunosuppressive Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Trial Comparing Chlorambucil to Fludarabine in Patients With Advanced Waldenström Macroglobulinemia Completed NCT00566332 Phase 3 Chlorambucil;Fludarabine
2 Chlorambucil or Fludarabine as First-Line Therapy in Treating Patients With Previously Untreated Waldenström Macroglobulinemia, Splenic Lymphoma, or Lymphoplasmacytic Lymphoma Completed NCT00608374 Phase 3 chlorambucil;fludarabine phosphate

Search NIH Clinical Center for Macroglobulinemia, Waldenstrom 1

Genetic Tests for Macroglobulinemia, Waldenstrom 1

Anatomical Context for Macroglobulinemia, Waldenstrom 1

MalaCards organs/tissues related to Macroglobulinemia, Waldenstrom 1:

38
Bone, Bone Marrow, B Cells, Lung

Publications for Macroglobulinemia, Waldenstrom 1

Variations for Macroglobulinemia, Waldenstrom 1

Expression for Macroglobulinemia, Waldenstrom 1

Search GEO for disease gene expression data for Macroglobulinemia, Waldenstrom 1.

Pathways for Macroglobulinemia, Waldenstrom 1

GO Terms for Macroglobulinemia, Waldenstrom 1

Sources for Macroglobulinemia, Waldenstrom 1

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42 MESH via Orphanet
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54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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