MCID: MCL030
MIFTS: 22

Macular Degeneration, Age-Related, 10

Categories: Genetic diseases, Eye diseases, Rare diseases

Aliases & Classifications for Macular Degeneration, Age-Related, 10

MalaCards integrated aliases for Macular Degeneration, Age-Related, 10:

Name: Macular Degeneration, Age-Related, 10 53 71 13 69
Armd10 53 12 71
Age Related Macular Degeneration 10 12
Age-Related Macular Degeneration 10 28

Classifications:



External Ids:

OMIM 53 611488
Disease Ontology 12 DOID:0110022
MedGen 39 C1969108
MeSH 41 D008268
UMLS 69 C1969108

Summaries for Macular Degeneration, Age-Related, 10

UniProtKB/Swiss-Prot : 71 Macular degeneration, age-related, 10: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.

MalaCards based summary : Macular Degeneration, Age-Related, 10, also known as armd10, is related to macular degeneration, age-related, 1. An important gene associated with Macular Degeneration, Age-Related, 10 is TLR4 (Toll Like Receptor 4). The drugs Ranibizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial.

Disease Ontology : 12 An age related macular degeneration associated with variation in the genomic region 9:112,100,000-127,500,000 (GRCh38). TLR4 has been put forth as a candidate gene.

Description from OMIM: 611488

Related Diseases for Macular Degeneration, Age-Related, 10

Symptoms & Phenotypes for Macular Degeneration, Age-Related, 10

Clinical features from OMIM:

611488

Drugs & Therapeutics for Macular Degeneration, Age-Related, 10

Drugs for Macular Degeneration, Age-Related, 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 2 347396-82-1 459903
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3 Mitogens Phase 2
4 Angiogenesis Inhibitors Phase 2
5 Angiogenesis Modulating Agents Phase 2
6 Endothelial Growth Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 X-82 to Treat Age-related Macular Degeneration Active, not recruiting NCT02348359 Phase 2 X-82;Anti-VEGF;Placebo

Search NIH Clinical Center for Macular Degeneration, Age-Related, 10

Genetic Tests for Macular Degeneration, Age-Related, 10

Genetic tests related to Macular Degeneration, Age-Related, 10:

# Genetic test Affiliating Genes
1 Age-Related Macular Degeneration 10 28 TLR4

Anatomical Context for Macular Degeneration, Age-Related, 10

MalaCards organs/tissues related to Macular Degeneration, Age-Related, 10:

38
Eye, Endothelial

Publications for Macular Degeneration, Age-Related, 10

Articles related to Macular Degeneration, Age-Related, 10:

# Title Authors Year
1
European survey on the opinion and use of micronutrition in age-related macular degeneration: 10 years on from the Age-Related Eye Disease Study. ( 25336904 )
2014

Variations for Macular Degeneration, Age-Related, 10

Expression for Macular Degeneration, Age-Related, 10

Search GEO for disease gene expression data for Macular Degeneration, Age-Related, 10.

Pathways for Macular Degeneration, Age-Related, 10

GO Terms for Macular Degeneration, Age-Related, 10

Sources for Macular Degeneration, Age-Related, 10

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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