Aliases & Classifications for Macular Holes

MalaCards integrated aliases for Macular Holes:

Name: Macular Holes 12 51 14 69
Macular Hole 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7633
MeSH 41 D012167
NCIt 46 C34795
SNOMED-CT 64 193388002 232006002
UMLS 69 C0024441

Summaries for Macular Holes

MalaCards based summary : Macular Holes, also known as macular hole, is related to central retinal vein occlusion and vitreous detachment. An important gene associated with Macular Holes is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are PEDF Induced Signaling and Response to elevated platelet cytosolic Ca2+. The drugs Ranibizumab and Verteporfin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotype is immune system.

Wikipedia : 72 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

Related Diseases for Macular Holes

Diseases related to Macular Holes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 central retinal vein occlusion 30.3 SERPINF1 VEGFA
2 vitreous detachment 30.3 KCNMA1 LHFPL5 VEGFA
3 macular retinal edema 30.2 KCNMA1 SERPINF1 VEGFA
4 microvascular complications of diabetes 5 30.1 ANGPT2 SERPINF1 VEGFA
5 retinal vein occlusion 30.0 CCL2 SERPINF1 VEGFA
6 vitreoretinopathy, neovascular inflammatory 29.9 ADM CCL2 TGFB2
7 diabetic macular edema 29.4 CCL2 SERPINF1 VEGFA
8 microvascular complications of diabetes 1 29.2 ANGPT2 CCL2 SERPINF1 TGFB2 VEGFA
9 macular degeneration, age-related, 1 29.2 CCL2 KCNMA1 SERPINF1 VEGFA
10 retinal disease 11.0
11 retinitis 10.9
12 retinal detachment 10.8
13 retinoschisis 1, x-linked, juvenile 10.4
14 streptococcal group a invasive disease 10.4
15 myopia 10.4
16 hydrops, lactic acidosis, and sideroblastic anemia 10.2
17 cataract 10.2
18 choroiditis 10.2
19 preretinal fibrosis 10.2 TGFB2 VEGFA
20 peyronie's disease 10.2 CCL2 TGFB2
21 coats disease 10.2
22 alport syndrome, x-linked 10.2
23 critical limb ischemia 10.2 ANGPT2 VEGFA
24 neovascular glaucoma 10.1 TGFB2 VEGFA
25 pyogenic granuloma 10.1 ANGPT2 VEGFA
26 background diabetic retinopathy 10.1 ANGPT2 VEGFA
27 poems syndrome 10.1 ANGPT2 VEGFA
28 diabetic cataract 10.1 SERPINF1 VEGFA
29 lipodermatosclerosis 10.1 ANGPT2 VEGFA
30 aging 10.1
31 microvascular complications of diabetes 2 10.1
32 neuropathy 10.1
33 vitreous disease 10.1 TGFB2 VEGFA
34 macular dystrophy, dominant cystoid 10.1 KCNMA1 VEGFA
35 eales disease 10.0 SERPINF1 VEGFA
36 retinitis pigmentosa 10.0
37 choroideremia 10.0
38 leber congenital amaurosis 4 10.0
39 neuroretinitis 10.0
40 scotoma 10.0
41 retinal vascular disease 10.0 ANGPT2 SERPINF1 VEGFA
42 hereditary hemorrhagic telangiectasia 10.0 ANGPT2 TGFB2 VEGFA
43 lymphangioma 10.0 SERPINF1 VEGFA
44 fibrosis of extraocular muscles, congenital, 1 9.9
45 myotonic dystrophy 1 9.9
46 von hippel-lindau syndrome 9.9
47 stargardt disease 9.9
48 exudative vitreoretinopathy 9.9
49 vitelliform macular dystrophy 9.9
50 vogt-koyanagi-harada disease 9.9

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to Macular Holes

Symptoms & Phenotypes for Macular Holes

MGI Mouse Phenotypes related to Macular Holes:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 ADM ALOX5AP ANGPT2 CCL2 MIF PTGDS

Drugs & Therapeutics for Macular Holes

Drugs for Macular Holes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 2 347396-82-1 459903
2
Verteporfin Approved, Investigational Phase 4 129497-78-5
3 Angiogenesis Inhibitors Phase 4,Phase 2
4 Angiogenesis Modulating Agents Phase 4,Phase 2
5 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
6 Dermatologic Agents Phase 4
7 Photosensitizing Agents Phase 4
8
Lutein Approved, Investigational, Nutraceutical Phase 3 127-40-2 6433159
9 Fibrinolytic Agents Phase 3,Phase 2
10 Plasminogen Phase 3,Phase 2
11 Mitogens Phase 2
12 Tetrahydrozoline Phase 2
13 Ophthalmic Solutions Phase 2,Phase 1
14
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
15 glucocorticoids Phase 1
16 Hormone Antagonists Phase 1
17 Hormones Phase 1
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
19 Anti-Inflammatory Agents Phase 1
20 Dexamethasone acetate Phase 1 1177-87-3
21
protease inhibitors Phase 1
22 Gastrointestinal Agents Phase 1
23 HIV Protease Inhibitors Phase 1
24 Dexamethasone 21-phosphate Phase 1
25 Peripheral Nervous System Agents Phase 1
26 Antiemetics Phase 1
27 Antineoplastic Agents, Hormonal Phase 1
28 BB 1101 Phase 1
29 Autonomic Agents Phase 1
30
Triamcinolone Approved, Vet_approved 124-94-7 31307
31
Temazepam Approved, Investigational 846-50-4 5391
32
Timolol Approved 26839-75-8 5478 33624
33
Dorzolamide Approved 120279-96-1 5284549 3154
34
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
35
Menthol Approved 2216-51-5 16666
36
Bevacizumab Approved, Investigational 216974-75-3
37
Dipivefrin Approved 52365-63-6 3105
38
Iodine Approved, Investigational 7553-56-2 807
39
Povidone-iodine Approved 25655-41-8
40
Povidone Approved 9003-39-8
41
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 11103-57-4 445354
42 tannic acid Approved, Nutraceutical
43 triamcinolone acetonide
44 Central Nervous System Depressants
45 GABA Agents
46 GABA Modulators
47 Neurotransmitter Agents
48 Tranquilizing Agents
49 Triamcinolone diacetate
50 Triamcinolone hexacetonide

Interventional clinical trials:

(show top 50) (show all 107)

# Name Status NCT ID Phase Drugs
1 Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery Completed NCT02930369 Phase 4
2 Assessment of Patients Treated With JETREA® for Vitreomacular Traction Completed NCT02035748 Phase 4 Ocriplasmin
3 Ocriplasmin for Vitreomacular Traction/Symptomatic Vitreomacular Adhesion Completed NCT02322229 Phase 4 Ocriplasmin 0.125 mg in a 0.1 mL volume
4 Study of Surgery in Patients With Idiopathic Macular Hole Recruiting NCT02905409 Phase 4
5 Cohort Study of the Clinical Course of Macular Diseases in Kagawa Recruiting NCT02321267 Phase 4 ranibizumab, aflibercept, pegaptanib, verteporphin
6 Brilliant Blue Versus Indocyanine Green Unknown status NCT01083004 Phase 3
7 Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery Unknown status NCT01820520 Phase 3 brilliant blue G
8 Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole Completed NCT01429441 Phase 3 Ocriplasmin
9 Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy Completed NCT01627977 Phase 3
10 Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-007) Trial. Completed NCT00798317 Phase 3 Ocriplasmin 125µg;Placebo
11 A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion Completed NCT01889251 Phase 3 Ocriplasmin;Sham injection
12 A Safety And Efficacy Study Of Alg-1001 In Human Subjects With Symptomatic Focal Vitreomacular Adhesion Completed NCT02153476 Phase 2 2.0mg of ALG-1001;Balanced Salt Solution
13 Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy Completed NCT00123279 Phase 2 Microplasmin
14 Analysis of Aqueous and Vitreous Humor Recruiting NCT02067013 Phase 2 Ranibizumab
15 Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal Terminated NCT00333060 Phase 2 OT-551 ophthalmic solution
16 PK Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Patients Undergoing Vitrectomy Completed NCT02644694 Phase 1 Dexamethasone Phosphate Ophthalmic Solution
17 Inverted ILM Repositioning as Treatment for Full Thickness Macular Holes Unknown status NCT01228188
18 Early Vitrectomy for Impending Macular Hole Unknown status NCT01121965
19 Macular Hole Surgery With and Without Internal Limiting Membrane Peeling:A Systematic Review and Meta-analysis Unknown status NCT01687829
20 The Intravitreal Autologous Platelet Concentrate Injection as an Adjunct of Vitrectomy for the Treatment of Refractory Macular Holes Unknown status NCT02081170
21 Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy Unknown status NCT01969929
22 Early Vitrectomy for Macular Tractional Maculopathy Unknown status NCT01121978
23 Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis Unknown status NCT02222857
24 Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel Unknown status NCT00892619
25 Spectral-domain Optical Coherence Tomography of the Eye Unknown status NCT02614625
26 Optical Coherence Tomography-based Positioning for Macular Hole Surgery Completed NCT02650739
27 Preoperative Progression of Macular Holes Completed NCT02203929
28 Foveal Cone Outer Segment Resumption to Predict Visual Recovery After Macular Hole Surgery Completed NCT01381965
29 Observation of Recovery of Foveal Cone Microstructures After Macular Hole Surgery Completed NCT01306487
30 Postoperative Positioning After Surgery for Macular Holes Completed NCT01974310
31 Air Tamponade in Macular Hole Surgery Completed NCT01680068
32 High Myopia Macular Hole and Retinal Detachment Treated With Double ILM Flaps Completed NCT03174639
33 Unveiling Preclinical Idiopathic Macular Hole Formation Completed NCT02180633
34 Air Tamponade in Macular Holes < 400 μm Completed NCT02028481
35 Fundus Autofluorescence After Macular Hole Surgery Completed NCT02628262
36 Comparative Study Between Early Vitrectomy and Observation for Spontaneous Closure of Traumatic Macular Hole Completed NCT01509092
37 Alleviated Positioning for Small Macular Holes Completed NCT00190164
38 Outcome of Idiopathic Macular Hole Completed NCT00941291
39 Trial of Prognostic Factors and Surgical Methods for the Treatment of Idiopathic Macular Holes Completed NCT00302328
40 Optical Coherence Tomography in Gas-filled Eyes Completed NCT01266746
41 Brillant Blue Versus Indocyanine Green for Macular Hole Surgery Completed NCT00757471
42 Microperimetry and Optical Coherence Tomography (OCT) in Idiopathic Macular Hole Completed NCT01757600
43 Inverted Internal Limiting Membrane Flap Technique for Macular Hole Retinal Detachment in Highly Myopic Eyes Completed NCT02896972
44 Macular Hole in Diabetic Retinopathy Completed NCT00737074
45 An Objective Evaluation of Postoperative Positioning in Macular Hole Surgery Completed NCT02011165
46 Combined Versus Successive Macular Hole and Cataract Surgery Completed NCT01069029
47 Elongation of Foveal Tissue After Macular Hole Surgery Completed NCT01471912
48 Epiretinal Proliferation in Eyes With Full Thickness Macular Hole Completed NCT03376776
49 Pilot Randomised Controlled Trial of Posturing Following Surgery for Full-thickness Macular Hole Completed NCT01226160 Early Phase 1
50 Evaluation of Anatomic and Visual Outcomes of Initially Closed Macular Holes Completed NCT01229657

Search NIH Clinical Center for Macular Holes

Genetic Tests for Macular Holes

Anatomical Context for Macular Holes

MalaCards organs/tissues related to Macular Holes:

38
Eye, Retina, Endothelial, Testes, Cortex

Publications for Macular Holes

Articles related to Macular Holes:

(show top 50) (show all 682)
# Title Authors Year
1
FULL-THICKNESS MACULAR HOLE WITH MACULAR INTRACHOROIDAL CAVITATION IN A PATIENT WITH PATHOLOGIC MYOPIA. ( 29443802 )
2018
2
MACULAR HOLE HYDRODISSECTION: Surgical Technique for the Treatment of Persistent, Chronic, and Large Macular Holes. ( 29303907 )
2018
3
Swept-Source OCT Angiography of Full-Thickness Macular Holes: Appearance and Artifacts. ( 29443360 )
2018
4
THE CURRENT SURGICAL MANAGEMENT OF LARGE, RECURRENT, OR PERSISTENT MACULAR HOLES. ( 29300247 )
2018
5
Multi-Scale Segmentation and Surface Fitting for Measuring 3-D Macular Holes. ( 29408786 )
2018
6
RECURRENT OPENING AND CLOSURE OF MACULAR HOLE AFTER PARS PLANA VITRECTOMY FOR RHEGMATOGENOUS RETINAL DETACHMENT. ( 29315126 )
2018
7
Current Management of Traumatic Macular Holes. ( 28239490 )
2017
8
Vitrectomy, Inner Limiting Membrane Peel, and Gas Tamponade in the Management of Traumatic Paediatric Macular Holes: A Case Series of 13 Patients. ( 28768260 )
2017
9
Novel Surgical Technique of Peeled Internal Limiting Membrane Reposition for Idiopathic Macular Holes. ( 28696343 )
2017
10
Internal limiting membrane flap transposition for surgical repair of macular holes in primary surgery and in persistent macular holes. ( 28967078 )
2017
11
NEW SURGICAL INSTRUMENT FOR AUTOLOGOUS INTERNAL LIMITING MEMBRANE TRANSPLANTATION FOR THE TREATMENT OF REFRACTORY MACULAR HOLES. ( 29117068 )
2017
12
Prevalence of anti-retinal antibodies in epiretinal membranes and macular holes. ( 29135070 )
2017
13
A Modified Foveal Advancement Technique in the Treatment of Persistent Large Macular Holes. ( 29020422 )
2017
14
Epidemiology and morphology of full-thickness macular holes. ( 29197164 )
2017
15
Vitrectomy for full-thickness macular hole in adult-onset Coats' disease. ( 29133668 )
2017
16
Re: Internal limiting membrane (ILM) transplantation for unclosed and large macular holes (MH). ( 28353012 )
2017
17
MACULAR HOLE IN A YOUNG PATIENT AFFECTED BY FAMILIAL EXUDATIVE VITREORETINOPATHY. ( 28850050 )
2017
18
Imaging of tangential traction types in lamellar macular holes. ( 28942521 )
2017
19
Idiopathic macular holes and direction of vitreomacular traction: structural changes and surgical outcomes. ( 28731057 )
2017
20
Outcome of Full-Thickness Macular Hole Surgery in Choroideremia. ( 28753983 )
2017
21
RETINA EXPANSION TECHNIQUE FOR MACULAR HOLE APPOSITION REPORT 2: Efficacy, Closure Rate, and Risks of a Macular Detachment Technique to Close Large Full-Thickness Macular Holes. ( 28816729 )
2017
22
Efficacy of the Perfluoro-N-Octane-Assisted Single-Layered Inverted Internal Limiting Membrane Flap Technique for Large Macular Holes. ( 28715813 )
2017
23
OCT angiography in idiopathic macular holes, some methodological concerns. ( 28669040 )
2017
24
Microstructural changes in the fovea following autologous internal limiting membrane transplantation surgery for large macular holes. ( 28636130 )
2017
25
Double Internal Limiting Membrane Insertion for Macular Hole-Associated Retinal Detachment. ( 28845304 )
2017
26
Internal Limiting Membrane Retracting Door for Myopic Macular Holes. ( 28737535 )
2017
27
EFFICACY OF THE INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE WITH VITRECTOMY FOR RETINAL DETACHMENT ASSOCIATED WITH MYOPIC MACULAR HOLES. ( 28225722 )
2017
28
Quantitative analysis of external limiting membrane, ellipsoid zone and interdigitation zone defects in patients with macular holes. ( 28412772 )
2017
29
New insights into the pathoanatomy of macular holes based on features of optical coherence tomography. ( 28300548 )
2017
30
Efficiency of the Hydraulic Centripetal Macular Displacement Technique in the Treatment of Traumatic Full-Thickness Macular Holes. ( 29117069 )
2017
31
Surgical treatment and optical coherence tomographic evaluation for accidental laser-induced full-thickness macular holes. ( 28282068 )
2017
32
INTERNAL LIMITING MEMBRANE PEELING VERSUS INVERTED FLAP TECHNIQUE FOR TREATMENT OF FULL-THICKNESS MACULAR HOLES: A COMPARATIVE STUDY IN A LARGE SERIES OF PATIENTS. ( 29232338 )
2017
33
INTERNAL ASPIRATION UNDER PERFLUOROCARBON LIQUID FOR THE MANAGEMENT OF LARGE MACULAR HOLES. ( 28333716 )
2017
34
Internal Repair of Very Large, Myopic and Recurrent Macular Holes by Creation of a Central Retinal Detachment and Silicone Oil Tamponade. ( 28858063 )
2017
35
Full-thickness macular hole: a rare complication of Borrelia burgdorferi neuroretinitis. ( 28473358 )
2017
36
PREVALENCE OF FOVEOLAR LUCENCY WITH DIFFERENT GAS TAMPONADES IN SURGICALLY CLOSED MACULAR HOLES ASSESSED BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY. ( 28699926 )
2017
37
Macular Buckling Surgery for Retinal Detachment Associated with Macular Hole in High Myopia Eye. ( 29326854 )
2017
38
Posterior Pole Retinal Detachment Due to a Macular Hole in a Patient with a Boston Keratoprosthesis. ( 28944307 )
2017
39
SUBRETINAL TRANSPLANTATION OF AN AUTOLOGOUS RETINAL FREE FLAP FOR CHRONIC RETINAL DETACHMENT WITH PROLIFERATIVE VITREORETINOPATHY WITH AND WITHOUT MACULAR HOLE. ( 29293208 )
2017
40
SUCCESSFUL CLOSURE OF FULL-THICKNESS MACULAR HOLES SECONDARY TO MACULAR VITELLIFORM LESIONS. ( 28333857 )
2017
41
A Case of Unilateral Retinitis Pigmentosa Associated with Full Thickness Macular Hole. ( 28936059 )
2017
42
Features Involved in the Healing Process of Macular Holes. ( 28687840 )
2017
43
Macular hole in Stargardt disease: Clinical and ultra-structural observation. ( 28121212 )
2017
44
Monitoring macular pigment changes in macular holes using fluorescence lifetime imaging ophthalmoscopy. ( 27775222 )
2016
45
Long-term Follow-up and Outcomes in Traumatic Macular Holes. ( 27084591 )
2016
46
RISK FACTORS FOR DEVELOPMENT OF MACULAR HOLE RETINAL DETACHMENT AFTER PARS PLANA VITRECTOMY FOR PATHOLOGIC MYOPIC FOVEOSCHISIS. ( 27652914 )
2016
47
INDUCTION OF MACULAR DETACHMENT FOR THE TREATMENT OF PERSISTENT OR RECURRENT IDIOPATHIC MACULAR HOLES. ( 26866526 )
2016
48
Aniseikonia and Foveal Microstructure in Patients with Idiopathic Macular Hole. ( 27406114 )
2016
49
Optimal management of idiopathic macular holes. ( 26834454 )
2016
50
CLOSING MACULAR HOLES WITH "MACULAR PLUG" WITHOUT GAS TAMPONADE AND POSTOPERATIVE POSTURING. ( 27491044 )
2016

Variations for Macular Holes

Expression for Macular Holes

Search GEO for disease gene expression data for Macular Holes.

GO Terms for Macular Holes

Cellular components related to Macular Holes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 ADM ANGPT2 CCL2 MIF PTGDS SERPINF1
2 extracellular space GO:0005615 9.23 ADM ANGPT2 CCL2 MIF PTGDS SERPINF1

Biological processes related to Macular Holes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of angiogenesis GO:0045766 9.61 ADM ANGPT2 VEGFA
2 angiogenesis GO:0001525 9.56 ANGPT2 CCL2 TGFB2 VEGFA
3 kidney development GO:0001822 9.54 SERPINF1 TGFB2 VEGFA
4 negative regulation of angiogenesis GO:0016525 9.5 ANGPT2 SERPINF1 TGFB2
5 positive chemotaxis GO:0050918 9.48 MIF VEGFA
6 protein homotrimerization GO:0070207 9.46 ALOX5AP MIF
7 negative regulation of gene expression GO:0010629 9.46 MIF SERPINF1 TGFB2 VEGFA
8 prostaglandin biosynthetic process GO:0001516 9.4 MIF PTGDS
9 regulation of receptor activity GO:0010469 9.35 ADM CCL2 MIF TGFB2 VEGFA
10 response to hypoxia GO:0001666 9.02 ADM ANGPT2 KCNMA1 TGFB2 VEGFA

Molecular functions related to Macular Holes according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL2 MIF TGFB2 VEGFA
2 chemoattractant activity GO:0042056 9.16 MIF VEGFA
3 receptor binding GO:0005102 9.02 ADM ANGPT2 CCL2 MIF TGFB2

Sources for Macular Holes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....