MCID: MCL003
MIFTS: 50

Macular Holes malady

Summaries for Macular Holes

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63Wikipedia, 32MalaCards
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Wikipedia:63 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

MalaCards: Macular Holes, also known as macular hole, is related to retinal detachment and vitreous detachment. An important gene associated with Macular Holes is TGFB2 (transforming growth factor, beta 2), and among its related pathways are Cell adhesion Plasmin signaling and Endochondral Ossification. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and cortex, and related mouse phenotypes are hearing/vestibular/ear and respiratory system.

Aliases & Classifications for Macular Holes

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

macular holes 8 10 44 60
macular hole 8


External Ids:

Disease Ontology8 DOID:7633
NCIt39 C34795
MeSH34 D012167

Related Diseases for Macular Holes

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17GeneCards, 18GeneDecks
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Diseases related to Macular Holes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1retinal detachment31.5HPRT1, PLAT, SERPINF1, GFAP, TGFB2, VEGFA
2vitreous detachment31.1LHFPL5
3cataract30.8SERPINF1, TGFB2
4retinal vein occlusion30.7VEGFA
5central retinal vein occlusion30.6VEGFA, PLAT
6diabetic retinopathy30.5TGFB2, VEGFA, ANGPT2, SERPINF1, ADM
7proliferative diabetic retinopathy30.5PTGDS, SERPINF1, ADM, TGFB2, GFAP, MIF
8scotoma30.4ABCA4
9macular retinal edema30.4VEGFA, SERPINF1
10eye disease30.4ABCA4, TGFB2, SERPINF1
11uveitis30.1SERPINF1, TGFB2
12retinopathy of prematurity30.1VEGFA
13hypertension30.1ADM, PLAT
14proliferative vitreoretinopathy30.1TGFB2, ADM, GFAP
15hemangioblastoma30.1GFAP, VEGFA
16age related macular degeneration30.1VEGFA, PLAT
17retinal disease30.1SERPINF1, GFAP, ABCA4, ANGPT2, VEGFA, ADM
18melanoma30.1ANGPT2, TGFB2, VIM, SERPINF1, HPRT1, VEGFA
19retinitis11.1
20retinoschisis10.7
21myopia10.6
22choroiditis10.5
23alport syndrome10.4
24cystoid macular edema10.4
25coats disease10.4
26retinitis pigmentosa10.2
27diabetic macular edema10.2
28vitelliform macular dystrophy10.2
29von hippel-lindau disease10.2
30choroideremia10.2
31myotonic dystrophy10.2
32myotonic dystrophy type 110.2
33stargardt disease10.1
34gyrate atrophy10.1
35neuroretinitis10.1
36ulnar neuropathy10.1
37cat-scratch disease10.1
38coloboma10.1
39vogt-koyanagi-harada disease10.1
40usher syndrome10.1
41exudative vitreoretinopathy10.1
42posterior uveal melanoma10.1
43osteogenesis imperfecta10.1
44hypertensive retinopathy10.1
45posterior uveitis10.1
46chorioretinitis10.1
47hypopyon10.1
48neuritis10.1
49neuropathy10.1
50optic neuritis10.1

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to macular holes

Clinical Features for Macular Holes

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Drugs & Therapeutics for Macular Holes

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Macular Holes

Drug clinical trials:

Search ClinicalTrials for Macular Holes

Search NIH Clinical Center for Macular Holes

Search CenterWatch for Macular Holes

Genetic Tests for Macular Holes

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Anatomical Context for Macular Holes

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32MalaCards
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MalaCards organs/tissues related to Macular Holes:

32
Eye, Retina, Cortex, Testes

Animal Models for Macular Holes or affiliated genes

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36MGI
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Publications for Macular Holes

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50PubMed
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Articles related to Macular Holes:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Autologous Transplantation of the Internal Limiting Membrane for Refractory Macular Holes. (24418265)
2014
2
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
3
INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR SURGICAL REPAIR OF MYOPIC MACULAR HOLES. (24263468)
2013
4
Risk factors for development of full-thickness macular holes after pars plana vitrectomy for myopic foveoschisis. (23522356)
2013
5
Full-thickness macular hole formation associated with central serous chorioretinopathy. (22729443)
2012
6
Arcuate Retinotomy for the Repair of Large Macular Holes. (23074973)
2012
7
Management of Stage IV Macular Holes: When Standard Surgery Fails. (23071465)
2012
8
Non-full-thickness macular holes: a closer look. (22165865)
2012
9
Long term result of silicone oil versus gas tamponade in the treatment of traumatic macular holes. (22259236)
2012
10
Vitreous surgery for macular hole-related retinal detachment after phacoemulsification cataract extraction: 10-year retrospective review. (22595907)
2012
11
Natural history of lamellar macular holes in highly myopic eyes. (21570052)
2011
12
Mathematical analysis of specific anatomic foveal configurations predisposing to the formation of macular holes. (21911580)
2011
13
Full Thickness Macular Hole Formation in a Patient with Cystoid Macular Edema Caused by CRVO Treated with Intravitreal Bevacizicumab. (20337340)
2010
14
Central photoreceptor viability and prediction of visual outcome in patients with idiopathic macular holes. (20714384)
2010
15
Combined 23-gauge, sutureless transconjunctival vitrectomy with phacoemulsification without face down posturing for the repair of idiopathic macular holes. (20075976)
2010
16
Full-thickness macular hole and macular telangiectasia in a child with Coats' disease. (22785154)
2010
17
Traumatic macular holes secondary to combat ocular trauma. (18997638)
2009
18
Extended internal limiting membrane peeling in the management of unusually large macular holes. (19320310)
2009
19
Secondary macular hole associated with central retinal vein occlusion treated with corticosteroid injection. (19484453)
2009
20
Lamellar macular holes: tomographic features and surgical outcome. (19493523)
2009
21
Macular holes: vitreoretinal relationships and surgical approaches. (18327161)
2008
22
Surgical outcomes for patients who develop macular holes after pars plana vitrectomy. (18378210)
2008
23
Ultrahigh-resolution optical coherence tomography (UHR-OCT) of macular holes. (18185160)
2008
24
Bilateral macular holes in usher syndrome. (16622392)
2006
25
Analysis of the retinal nerve fiber layer after indocyanine green-assisted vitrectomy for idiopathic macular holes. (16458094)
2006
26
Pars plana vitrectomy with internal limiting membrane removal for macular hole associated with proliferative diabetic retinopathy. (15657774)
2005
27
Posterior vitreous detachment and macular hole formation in myopic foveoschisis. (15629315)
2004
28
Evaluation of the retinal nerve fiber layer thickness in eyes with idiopathic macular holes. (11384573)
2001
29
Prevalence, correlates, and natural history of epiretinal membranes surrounding idiopathic macular holes. Virectomy for Macular Hole Study Group. (10811074)
2000
30
Epiretinal membranous tissue in retinal detachment due to macular holes in highly myopic eyes (10715395)
2000
31
Pars plana vitrectomy for macular holes combined with cataract extraction and lens implantation. (11011707)
2000
32
Silicone oil tamponade for macular holes. (10647706)
2000
33
Estimation of the retinal nerve fibre layer thickness in the papillomacular area of long standing stage IV macular holes. (10216057)
1999
34
Ultrastructure of epiretinal membranes associated with macular holes. (9561355)
1998
35
Autologous platelet concentrate in the surgical management of macular holes. (9413692)
1997
36
Spontaneous evolution of stage I and II macular holes. (9745812)
1997
37
Macular hole surgery. Comparison of longstanding versus recent macular holes. (8942875)
1996
38
Postoperative hypopyon after intravitreal bovine thrombin for macular hole surgery. (8610806)
1996
39
Treatment of idiopathic macular holes by induced posterior vitreous detachment. (7777275)
1995
40
Clinical correlation of ultrasonographic findings in macular holes. (7573327)
1995
41
Ultrasound of macular holes. (7891970)
1995
42
Idiopathic macular hole: a clinical review and current concepts in the diagnosis and management. (7852702)
1994
43
Vitelliform macular dystrophy: a cause of macular holes with retinal detachments. (7821484)
1994
44
Atypical presentations of macular holes. (8155043)
1994
45
Risk of decreased visual acuity in full-thickness idiopathic macular holes. (8250073)
1993
46
Modified vitrectomy for impending macular holes. (1787938)
1991
47
Macular holes and excellent visual acuity. Case report. (3178546)
1988
48
Treatment of retinal detachments due to macular holes. (6494630)
1984
49
Macular holes. (6906170)
1980
50
Macular holes and retinoschisis. (4666772)
1972

Genetic Variations for Macular Holes

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Expression for genes affiliated with Macular Holes

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macular Holes

Search GEO for disease gene expression data for Macular Holes.

Pathways for genes affiliated with Macular Holes

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12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Macular Holes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0PLAT
210.0PLAT
39.1GFAP, MIF, VIM

Compounds for genes affiliated with Macular Holes

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Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Macular Holes according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7PTGDS
2estrogen4410.5GFAP
3trifluorothymidine59 4411.1PTGDS, HPRT1
4tamoxifen44 49 28 1113.1KCNMA1
5matrigel4410.1TGFB2, VIM
6verteporfin4410.0SERPINF1, VEGFA
7heparin44 28 11 2412.9VEGFA, SERPINF1
8n-ethyl-n-nitrosourea449.8HPRT1, GFAP
9fluorescein44 1110.7VEGFA, SERPINF1, ADM
10beraprost sodium449.7PLAT, ADM
11indomethacin44 59 28 1112.7PLAT, ADM
12prostaglandin449.7VIM, PTGDS, TGFB2
13spec-t449.6ADM, PLAT, GFAP
14serine449.6SERPINF1, MIF, HPRT1, GFAP
15pge2449.5VEGFA, KCNMA1
16forskolin44 49 1111.5ADM, VIM, GFAP
17creatinine449.5TGFB2, PTGDS, GFAP, HPRT1, ANGPT2
18glyceraldehyde 3-phosphate449.5GFAP, HPRT1, ANGPT2, ADM
19hydrocortisone44 2 59 1112.4ADM, MIF, VIM, TGFB2
20streptozotocin449.3ADM, SERPINF1, GFAP, VIM
21silicone449.3VIM, GFAP, PLAT
22vitamin a44 11 2411.3HPRT1, TGFB2, ABCA4, VIM
23dexamethasone44 49 28 1112.2TGFB2, SERPINF1, GFAP, ANGPT2, VEGFA
24thymidine44 2410.1TGFB2, HPRT1, ADM, GFAP, ANGPT2, MIF
25neomycin448.8HPRT1, GFAP, VIM
26glutamate448.8KCNMA1, HPRT1, GFAP, PLAT
27potassium44 11 2410.8TGFB2, KCNMA1, SERPINF1, GFAP, ADM
28estradiol44 11 2410.8GFAP, VIM, TGFB2, KCNMA1
29testosterone44 59 11 2411.8GFAP, PTGDS, TGFB2, ADM, VIM, HPRT1
30genistein44 28 59 2 11 2413.7GFAP, MIF, TGFB2, VEGFA, VIM
31oxygen44 249.6KCNMA1, ADM, ANGPT2, GFAP, SERPINF1
32prostacyclin448.6ADM, PLAT, VEGFA, KCNMA1
33nitric oxide44 11 2410.6MIF, ADM, KCNMA1, SERPINF1, TGFB2, ANGPT2
34methionine448.4VIM, SERPINF1, GFAP, MIF, KCNMA1
35guanylate448.4VIM, KCNMA1, ANGPT2, HPRT1, ADM, SERPINF1
36histamine44 28 2410.4KCNMA1, VIM, ADM, PTGDS, PLAT
37h2o2448.3HPRT1, VIM, ANGPT2, SERPINF1, KCNMA1, MIF
38progesterone44 59 28 11 2412.3TGFB2, ADM, GFAP, PLAT, VIM
39cyclic amp44 249.3TGFB2, ADM, GFAP, KCNMA1, VIM
40isoproterenol44 119.2ADM, PLAT, GFAP, KCNMA1, VIM
41cholesterol44 28 11 2411.1KCNMA1, PLAT, PTGDS, ABCA4, ADM, GFAP
42vegf448.0ADM, VIM, VEGFA, TGFB2, ANGPT2, MIF
43adenylate447.9VIM, PLAT, ADM, KCNMA1, HPRT1, GFAP
44glucose447.8TGFB2, ADM, GFAP, PLAT, MIF, ANGPT2
45retinoic acid44 248.8GFAP, ANGPT2, MIF, PLAT, VIM, PTGDS
46paraffin447.7VEGFA, GFAP, TGFB2, PLAT, MIF, ADM
47atp44 288.7VIM, KCNMA1, ANGPT2, ABCA4, ADM, GFAP
48tyrosine447.7KCNMA1, VEGFA, MIF, GFAP, ANGPT2, TGFB2
49cysteine447.7VIM, HPRT1, MIF, PLAT, GFAP, SERPINF1
50lipid447.6ADM, VIM, KCNMA1, MIF, GFAP, PTGDS

GO Terms for genes affiliated with Macular Holes

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16Gene Ontology
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Cellular components related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8ANGPT2, MIF, PLAT, PTGDS, SERPINF1, ADM
2extracellular spaceGO:0056157.5TGFB2, VEGFA, ANGPT2, MIF, PLAT, PTGDS

Biological processes related to Macular Holes according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:0311029.9GFAP, ADM
2response to woundingGO:0096119.7TGFB2, ADM, GFAP
3activation of protein kinase activityGO:0321479.7TGFB2, VEGFA
4Bergmann glial cell differentiationGO:0600209.7GFAP, VIM
5prostaglandin biosynthetic processGO:0015169.6PTGDS, MIF
6response to glucocorticoid stimulusGO:0513849.5ADM, PTGDS, PLAT
7astrocyte developmentGO:0140029.5GFAP, VIM
8positive regulation of angiogenesisGO:0457669.4VEGFA, ANGPT2, ADM
9intermediate filament organizationGO:0451099.3GFAP, VIM
10blood coagulationGO:0075968.3KCNMA1, VEGFA, ANGPT2, PLAT, TGFB2
11response to hypoxiaGO:0016668.1TGFB2, KCNMA1, VEGFA, ANGPT2, PLAT, ADM

Molecular functions related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.6MIF, VEGFA
2receptor bindingGO:0051029.1TGFB2, ADM, MIF, ANGPT2

Products for genes affiliated with Macular Holes

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Sources for Macular Holes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet