MCID: MCL003
MIFTS: 52

Macular Holes malady

Eye diseases category
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Summaries for Macular Holes

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Wikipedia:65 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

MalaCards based summary: Macular Holes, also known as macular hole, is related to vitreous detachment and cataract. An important gene associated with Macular Holes is TGFB2 (transforming growth factor, beta 2), and among its related pathways are PEDF Induced Signaling and Spinal Cord Injury. The compounds trifluorothymidine and n-ethyl-n-nitrosourea have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and cortex, and related mouse phenotypes are integument and hearing/vestibular/ear.

Aliases & Classifications for Macular Holes

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT
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Macular Holes, Aliases & Descriptions:

Name: Macular Holes 8 10 44 62
 
Macular Hole 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:7633
MeSH34 D012167
NCIt39 C34795

Related Diseases for Macular Holes

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Diseases related to Macular Holes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1vitreous detachment31.9LHFPL5
2cataract31.5SERPINF1, TGFB2
3central retinal vein occlusion31.1PLAT
4retinal detachment31.1GFAP, TGFB2, SERPINF1, HPRT1, PLAT
5proliferative vitreoretinopathy31.0TGFB2
6diabetic retinopathy30.9TGFB2, SERPINF1, ADM, ANGPT2
7age related macular degeneration30.5PLAT
8proliferative diabetic retinopathy30.1GFAP, PTGDS, TGFB2, SERPINF1, ADM, ANGPT2
9melanoma30.0TGFB2, SERPINF1, VIM, ANGPT2, HPRT1
10retinitis11.2
11retinoschisis10.8
12myopia10.7
13retinal vein occlusion10.6
14choroiditis10.5
15alport syndrome10.5
16coats disease10.5
17cystoid macular edema10.5
18hemangiopericytoma10.4VIM
19mixed glioma10.4GFAP
20neurilemmoma10.4GFAP
21syringoma10.4GFAP
22scotoma10.4
23macular dystrophy10.4
24choroid plexus papilloma10.4GFAP
25subependymal giant cell astrocytoma10.3GFAP
26giant cell glioblastoma10.3GFAP
27primary open angle glaucoma10.3TGFB2, ABCA4
28retinitis pigmentosa10.3
29von hippel-lindau disease10.3
30myotonic dystrophy type 110.3
31vitelliform macular dystrophy10.3
32choroideremia10.3
33eye disease10.3
34neuropathy10.3
35myotonic dystrophy10.3
36x-linked juvenile retinoschisis10.3
37schisis association10.3
38shaken baby syndrome10.3
39coronary thrombosis10.3PLAT
40pneumonia10.2ADM, TGFB2, PTGDS
41septic shock10.2ADM, ANGPT2, MIF
42malaria10.2HPRT1, MIF
43angiosarcoma10.2ANGPT2, VIM
44infertility10.2PTGDS, TGFB2, MIF
45primary hyperoxaluria10.2PTGDS, ADM, HPRT1
46diabetic nephropathy10.2SERPINF1, ADM, MIF
47spiradenoma10.2SERPINF1, TGFB2, ABCA4
48rhabdoid meningioma10.2VIM, GFAP
49astroblastoma10.2VIM, GFAP
50myoepithelioma10.1VIM, GFAP

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to macular holes

Symptoms for Macular Holes

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Drugs & Therapeutics for Macular Holes

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Drug clinical trials:

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Genetic Tests for Macular Holes

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Anatomical Context for Macular Holes

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MalaCards organs/tissues related to Macular Holes:

32
Eye, Retina, Cortex, Testes

Animal Models for Macular Holes or affiliated genes

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Publications for Macular Holes

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Articles related to Macular Holes:

(show top 50)    (show all 561)
idTitleAuthorsYear
1
Inverted ILM peeling for idiopathic and other etiology macular holes. (25230973)
2014
2
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
3
Management of rhegmatogenous retinal detachment with coexisting macular hole: a comparison of vitrectomy with and without internal limiting membrane peeling. (23222496)
2013
4
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
5
Foveal thickness in healthy fellow eyes of patients with unilateral macular holes. (23540711)
2013
6
23- vs 20-gauge pars plana vitrectomy in combination with bimanual microincisional cataract surgery (b-MICS) for the treatment of macular hole and cataract as a one-step procedure. (23743530)
2013
7
Surgery for macular holes associated with unusual concomitant pathologies. (24082671)
2013
8
Analysis of Retinal Ganglion Cell Complex Thickness after Brilliant Blue-Assisted Vitrectomy for Idiopathic Macular Holes. (24143870)
2013
9
Episcleral macular buckling for posterior retinal detachment in silicone oil filled eyes associated with myopic macular hole. (23638417)
2013
10
INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR SURGICAL REPAIR OF MYOPIC MACULAR HOLES. (24263468)
2013
11
Spontaneous macular hole closure without posterior vitreous detachment in a patient previously treated for diabetic maculopathy. (22973980)
2013
12
Traction-induced foveal damage predisposes eyes with pre-existing posterior vitreous detachment to idiopathic macular hole formation. (22388594)
2012
13
Retinoschisis: a predictive factor in vitrectomy for macular holes without retinal detachment in highly myopic eyes. (21586755)
2012
14
SD-OCT imaging of idiopathic macular holes with spontaneous closure. (22356437)
2012
15
Full-thickness macular hole formation associated with central serous chorioretinopathy. (22729443)
2012
16
Scleral buckling in rhegmatogenous retinal detachment with concomitant full-thickness macular hole. (21726425)
2012
17
The dynamic healing process of idiopathic macular holes after surgical repair: a spectral-domain optical coherence tomography study. (21345999)
2011
18
1000 cSt silicone oil vs heavy silicone oil as intraocular tamponade in retinal detachment associated to myopic macular hole. (21080197)
2011
19
Non-Foveal Macular Holes After PPV for Macular Pucker. (20844682)
2010
20
Traumatic macular holes secondary to combat ocular trauma. (18997638)
2009
21
Extended internal limiting membrane peeling in the management of unusually large macular holes. (19320310)
2009
22
Parafoveal telangiectasia (PFT) has been associated with changes in macular architecture and macular holes (lamellar and full thickness). (18185162)
2008
23
Outcomes of 23- and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macular holes. (18614566)
2008
24
Treatment of stage 2 macular hole by intravitreous injection of expansile gas and induction of posterior vitreous detachment. (17070585)
2007
25
Successful treatment of macular holes associated with peripheral retinal vascular tumours. (16710432)
2007
26
Stage 0 macular holes. (16061097)
2005
27
Foveal schisis as a cause of retinal detachment secondary to macular hole in juvenile X-linked retinoschisis. (15805920)
2005
28
Assessing responses of the macula in patients with macular holes using a new system measuring localized visual acuity and the mfERG. (16328926)
2005
29
Retinal telangiectasia in association with macular hole formation. (14716321)
2004
30
Macular holes: classification, epidemiology, natural history and treatment. (12485276)
2002
31
Bilateral macular holes: an unusual feature of alport syndrome. (12172121)
2002
32
Clinical pathogenesis of macular holes in patients affected by retinitis pigmentosa. (12708609)
2002
33
Surgery for full-thickness macular holes. (11733243)
2001
34
The visual performance and metamorphopsia of patients with macular holes. (10636412)
2000
35
Visual and anatomical results of surgery for long standing macular holes. (10655189)
2000
36
A new approach to stage 3 macular holes. (10919918)
2000
37
Time course of the size of the dark area in macular holes by scanning laser ophthalmoscopy. (10770618)
2000
38
Prevalence, correlates, and natural history of epiretinal membranes surrounding idiopathic macular holes. Virectomy for Macular Hole Study Group. (10811074)
2000
39
Morphological evaluation of full-thickness idiopathic macular holes by optical coherence tomography. (10544977)
1999
40
Anomaloscope examination in macular gliosis, macular holes and central serous choroidopathy. (9602315)
1998
41
Macular holes and PVD. (8600404)
1996
42
Autologous platelet concentrate for the treatment of full-thickness macular holes. (8543204)
1995
43
Full-thickness macular holes treated with vitrectomy and tissue glue. (7642336)
1994-1995
44
A prospective natural history study and kinetic ultrasound evaluation of idiopathic macular holes. (8302564)
1994
45
Results of surgical treatment of recent-onset full-thickness idiopathic macular holes. (7993209)
1994
46
Risk of decreased visual acuity in full-thickness idiopathic macular holes. (8250073)
1993
47
Transforming growth factor-beta 2 for the treatment of full-thickness macular holes. A prospective randomized study. (1495798)
1992
48
Causative factors of retinal detachment in macular holes. (1961986)
1991
49
Treatment of retinal detachment due to macular holes without chorio-retinal lesions. A seven-year follow-up study. (6963057)
1982
50
Macular holes associated with proliferative sickle cell retinopathy. (687199)
1978

Variations for Macular Holes

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Expression for genes affiliated with Macular Holes

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Expression patterns in normal tissues for genes affiliated with Macular Holes

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Pathways for genes affiliated with Macular Holes

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Compounds for genes affiliated with Macular Holes

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Compounds related to Macular Holes according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1trifluorothymidine44 6111.2HPRT1, PTGDS
2n-ethyl-n-nitrosourea449.8GFAP, HPRT1
3beraprost sodium449.6ADM, PLAT
4eosin449.6VIM, GFAP
5prostaglandin449.5ADM, VIM, TGFB2, PTGDS
6hydrocortisone44 2 61 1112.4MIF, ADM, VIM, TGFB2
7omapatrilat449.4PLAT, ADM
8catecholamine449.4VIM, ADM, MIF
9corticosterone44 61 2411.4MIF, ADM, GFAP
10s 100449.3VIM, GFAP
11glyceraldehyde 3-phosphate449.3HPRT1, ANGPT2, ADM, GFAP
12dbc-amp449.3ADM, VIM, GFAP
13neomycin449.3GFAP, VIM, HPRT1
14nitric oxide44 24 1111.2TGFB2, SERPINF1, ADM, ANGPT2, MIF
15potassium44 24 1111.2GFAP, TGFB2, SERPINF1, ADM
16guanylate449.2SERPINF1, VIM, ADM, ANGPT2, HPRT1
17streptozotocin449.1GFAP, SERPINF1, VIM, ADM
18spec-t449.1GFAP, ADM, PLAT
19p003449.0TGFB2, ADM, PLAT
20vitamin a44 24 1111.0ABCA4, PTGDS, TGFB2, VIM, HPRT1
21methionine449.0MIF, VIM, SERPINF1, GFAP
22forskolin44 50 1111.0GFAP, TGFB2, VIM, ADM
23indomethacin44 28 61 1111.9TGFB2, VIM, ADM, PLAT
24silicone448.9PLAT, VIM, GFAP
25genistein44 28 61 2 24 1113.9MIF, VIM, TGFB2, GFAP
26histamine44 28 2410.8PLAT, ADM, VIM, PTGDS
27morphine44 50 28 1111.8HPRT1, MIF, GFAP
28cyclosporin a44 28 6110.8PLAT, ANGPT2, ADM, TGFB2
29h2o2448.8SERPINF1, VIM, ADM, ANGPT2, MIF, HPRT1
30thymidine44 249.7GFAP, TGFB2, ADM, ANGPT2, MIF, HPRT1
31tamoxifen44 50 28 1111.6TGFB2, VIM, ADM, HPRT1, PLAT
32isoproterenol44 119.6GFAP, VIM, ADM, PLAT
33testosterone44 61 24 1111.6GFAP, PTGDS, TGFB2, VIM, ADM, HPRT1
34progesterone44 28 61 24 1112.3GFAP, TGFB2, VIM, ADM, PLAT
35estradiol44 24 1110.3GFAP, TGFB2, VIM, MIF, PLAT
36cholesterol44 28 24 1111.3ABCA4, GFAP, PTGDS, ADM, PLAT
37estrogen448.3GFAP, PTGDS, TGFB2, VIM, ADM, ANGPT2
38vegf448.2GFAP, TGFB2, SERPINF1, VIM, ADM, ANGPT2
39adenylate448.2GFAP, VIM, ADM, HPRT1, PLAT
40lipid448.2ABCA4, GFAP, PTGDS, VIM, ADM, MIF
41cycloheximide448.1GFAP, PTGDS, TGFB2, VIM, ADM, PLAT
42glutamate448.0GFAP, TGFB2, SERPINF1, VIM, HPRT1, PLAT
43glucose447.9GFAP, TGFB2, SERPINF1, ADM, ANGPT2, MIF
44dexamethasone44 50 28 1110.9GFAP, TGFB2, SERPINF1, VIM, ADM, ANGPT2
45matrigel447.8GFAP, TGFB2, SERPINF1, VIM, ADM, ANGPT2
46paraffin447.8GFAP, TGFB2, VIM, ADM, ANGPT2, MIF
47serine447.4GFAP, TGFB2, SERPINF1, VIM, ANGPT2, MIF
48retinoic acid44 248.2GFAP, PTGDS, TGFB2, SERPINF1, VIM, ADM
49creatinine447.1PLAT, GFAP, PTGDS, TGFB2, VIM, ADM
50cysteine447.1GFAP, TGFB2, SERPINF1, VIM, ADM, ANGPT2

GO Terms for genes affiliated with Macular Holes

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Cellular components related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.8TGFB2, SERPINF1, PLAT
2extracellular vesicular exosomeGO:0700628.1PLAT, HPRT1, MIF, VIM, SERPINF1
3extracellular spaceGO:0056157.9PLAT, PTGDS, TGFB2, SERPINF1, ADM, ANGPT2
4extracellular regionGO:0055767.8PTGDS, TGFB2, SERPINF1, ADM, ANGPT2, MIF

Biological processes related to Macular Holes according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:0311029.6ADM, GFAP
2prostaglandin biosynthetic processGO:0015169.5MIF, PTGDS
3Bergmann glial cell differentiationGO:0600209.5VIM, GFAP
4response to woundingGO:0096119.4GFAP, TGFB2, ADM
5astrocyte developmentGO:0140029.3VIM, GFAP
6negative regulation of neuron projection developmentGO:0109779.3VIM, GFAP
7intermediate filament organizationGO:0451099.2GFAP, VIM
8response to hypoxiaGO:0016669.0TGFB2, ADM, ANGPT2, PLAT
9response to glucocorticoidGO:0513849.0PLAT, ADM, SERPINF1, PTGDS

Molecular functions related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3MIF, ANGPT2, ADM, TGFB2

Products for genes affiliated with Macular Holes

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Sources for Macular Holes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet