MCID: MCL003
MIFTS: 50

Macular Holes malady

Summaries for Macular Holes

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Wikipedia:65 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

MalaCards based summary: Macular Holes, also known as macular hole, is related to retinal detachment and vitreous detachment. An important gene associated with Macular Holes is TGFB2 (transforming growth factor, beta 2), and among its related pathways are PEDF Induced Signaling and Spinal Cord Injury. The compounds trifluorothymidine and n-ethyl-n-nitrosourea have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and cortex, and related mouse phenotypes are integument and hearing/vestibular/ear.

Aliases & Classifications for Macular Holes

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Macular Holes, Aliases & Descriptions:

Name: Macular Holes 10 12 45 62
 
Macular Hole 10


External Ids:

Disease Ontology10 DOID:7633
NCIt40 C34795
MeSH35 D012167

Related Diseases for Macular Holes

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Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to macular holes

Symptoms for Macular Holes

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Drugs & Therapeutics for Macular Holes

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Drug clinical trials:

Search ClinicalTrials for Macular Holes

Search NIH Clinical Center for Macular Holes

Genetic Tests for Macular Holes

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Anatomical Context for Macular Holes

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MalaCards organs/tissues related to Macular Holes:

33
Eye, Retina, Cortex, Testes

Animal Models for Macular Holes or affiliated genes

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Publications for Macular Holes

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Articles related to Macular Holes:

(show top 50)    (show all 575)
idTitleAuthorsYear
1
Inverted ILM peeling for idiopathic and other etiology macular holes. (25230973)
2014
2
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
3
Management of rhegmatogenous retinal detachment with coexisting macular hole: a comparison of vitrectomy with and without internal limiting membrane peeling. (23222496)
2013
4
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
5
Foveal thickness in healthy fellow eyes of patients with unilateral macular holes. (23540711)
2013
6
23- vs 20-gauge pars plana vitrectomy in combination with bimanual microincisional cataract surgery (b-MICS) for the treatment of macular hole and cataract as a one-step procedure. (23743530)
2013
7
Risk assessment of idiopathic macular holes undergoing vitrectomy with dye-assisted internal limiting membrane peeling. (23514792)
2013
8
Surgery for macular holes associated with unusual concomitant pathologies. (24082671)
2013
9
Analysis of Retinal Ganglion Cell Complex Thickness after Brilliant Blue-Assisted Vitrectomy for Idiopathic Macular Holes. (24143870)
2013
10
Episcleral macular buckling for posterior retinal detachment in silicone oil filled eyes associated with myopic macular hole. (23638417)
2013
11
INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR SURGICAL REPAIR OF MYOPIC MACULAR HOLES. (24263468)
2013
12
Spontaneous macular hole closure without posterior vitreous detachment in a patient previously treated for diabetic maculopathy. (22973980)
2013
13
Traction-induced foveal damage predisposes eyes with pre-existing posterior vitreous detachment to idiopathic macular hole formation. (22388594)
2012
14
Retinoschisis: a predictive factor in vitrectomy for macular holes without retinal detachment in highly myopic eyes. (21586755)
2012
15
SD-OCT imaging of idiopathic macular holes with spontaneous closure. (22356437)
2012
16
Full-thickness macular hole formation associated with central serous chorioretinopathy. (22729443)
2012
17
The dynamic healing process of idiopathic macular holes after surgical repair: a spectral-domain optical coherence tomography study. (21345999)
2011
18
1000 cSt silicone oil vs heavy silicone oil as intraocular tamponade in retinal detachment associated to myopic macular hole. (21080197)
2011
19
Non-Foveal Macular Holes After PPV for Macular Pucker. (20844682)
2010
20
Traumatic macular holes secondary to combat ocular trauma. (18997638)
2009
21
Extended internal limiting membrane peeling in the management of unusually large macular holes. (19320310)
2009
22
Parafoveal telangiectasia (PFT) has been associated with changes in macular architecture and macular holes (lamellar and full thickness). (18185162)
2008
23
Outcomes of 23- and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macular holes. (18614566)
2008
24
Treatment of stage 2 macular hole by intravitreous injection of expansile gas and induction of posterior vitreous detachment. (17070585)
2007
25
Successful treatment of macular holes associated with peripheral retinal vascular tumours. (16710432)
2007
26
Stage 0 macular holes. (16061097)
2005
27
Foveal schisis as a cause of retinal detachment secondary to macular hole in juvenile X-linked retinoschisis. (15805920)
2005
28
Assessing responses of the macula in patients with macular holes using a new system measuring localized visual acuity and the mfERG. (16328926)
2005
29
Retinal telangiectasia in association with macular hole formation. (14716321)
2004
30
Macular holes: classification, epidemiology, natural history and treatment. (12485276)
2002
31
Bilateral macular holes: an unusual feature of alport syndrome. (12172121)
2002
32
Clinical pathogenesis of macular holes in patients affected by retinitis pigmentosa. (12708609)
2002
33
Surgery for full-thickness macular holes. (11733243)
2001
34
The visual performance and metamorphopsia of patients with macular holes. (10636412)
2000
35
Visual and anatomical results of surgery for long standing macular holes. (10655189)
2000
36
A new approach to stage 3 macular holes. (10919918)
2000
37
Time course of the size of the dark area in macular holes by scanning laser ophthalmoscopy. (10770618)
2000
38
Prevalence, correlates, and natural history of epiretinal membranes surrounding idiopathic macular holes. Virectomy for Macular Hole Study Group. (10811074)
2000
39
Morphological evaluation of full-thickness idiopathic macular holes by optical coherence tomography. (10544977)
1999
40
Anomaloscope examination in macular gliosis, macular holes and central serous choroidopathy. (9602315)
1998
41
Macular holes and PVD. (8600404)
1996
42
Autologous platelet concentrate for the treatment of full-thickness macular holes. (8543204)
1995
43
Full-thickness macular holes treated with vitrectomy and tissue glue. (7642336)
1994-1995
44
A prospective natural history study and kinetic ultrasound evaluation of idiopathic macular holes. (8302564)
1994
45
Results of surgical treatment of recent-onset full-thickness idiopathic macular holes. (7993209)
1994
46
Risk of decreased visual acuity in full-thickness idiopathic macular holes. (8250073)
1993
47
Transforming growth factor-beta 2 for the treatment of full-thickness macular holes. A prospective randomized study. (1495798)
1992
48
Causative factors of retinal detachment in macular holes. (1961986)
1991
49
Treatment of retinal detachment due to macular holes without chorio-retinal lesions. A seven-year follow-up study. (6963057)
1982
50
Macular holes associated with proliferative sickle cell retinopathy. (687199)
1978

Variations for Macular Holes

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Expression for genes affiliated with Macular Holes

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Search GEO for disease gene expression data for Macular Holes.

Pathways for genes affiliated with Macular Holes

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Compounds for genes affiliated with Macular Holes

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Compounds related to Macular Holes according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1trifluorothymidine45 6111.2HPRT1, PTGDS
2n-ethyl-n-nitrosourea459.8HPRT1, GFAP
3beraprost sodium459.6PLAT, ADM
4eosin459.6GFAP, VIM
5prostaglandin459.5PTGDS, VIM, TGFB2, ADM
6hydrocortisone45 3 61 1312.4MIF, ADM, VIM, TGFB2
7omapatrilat459.4PLAT, ADM
8catecholamine459.4ADM, VIM, MIF
9corticosterone45 61 2611.4ADM, MIF, GFAP
10s 100459.3GFAP, VIM
11glyceraldehyde 3-phosphate459.3HPRT1, ANGPT2, ADM, GFAP
12dbc-amp459.3GFAP, VIM, ADM
13neomycin459.3VIM, GFAP, HPRT1
14nitric oxide45 26 1311.2ADM, MIF, ANGPT2, SERPINF1, TGFB2
15potassium45 26 1311.2TGFB2, GFAP, SERPINF1, ADM
16guanylate459.2HPRT1, ANGPT2, ADM, VIM, SERPINF1
17streptozotocin459.1ADM, GFAP, VIM, SERPINF1
18spec-t459.1GFAP, ADM, PLAT
19p003459.0TGFB2, ADM, PLAT
20vitamin a45 26 1311.0ABCA4, HPRT1, VIM, PTGDS, TGFB2
21methionine459.0VIM, GFAP, MIF, SERPINF1
22forskolin45 51 1311.0TGFB2, GFAP, ADM, VIM
23indomethacin45 30 61 1311.9PLAT, ADM, VIM, TGFB2
24silicone458.9GFAP, VIM, PLAT
25genistein45 30 61 3 26 1313.9VIM, MIF, GFAP, TGFB2
26histamine45 30 2610.8VIM, PTGDS, ADM, PLAT
27morphine45 51 30 1311.8GFAP, HPRT1, MIF
28cyclosporin a45 30 6110.8TGFB2, ADM, ANGPT2, PLAT
29h2o2458.8MIF, ANGPT2, ADM, SERPINF1, VIM, HPRT1
30thymidine45 269.7HPRT1, TGFB2, ADM, ANGPT2, MIF, GFAP
31tamoxifen45 51 30 1311.6ADM, VIM, TGFB2, PLAT, HPRT1
32isoproterenol45 139.6PLAT, ADM, GFAP, VIM
33testosterone45 61 26 1311.6GFAP, PTGDS, HPRT1, ADM, VIM, TGFB2
34progesterone45 30 61 26 1312.3ADM, TGFB2, PLAT, VIM, GFAP
35estradiol45 26 1310.3VIM, TGFB2, MIF, PLAT, GFAP
36cholesterol45 30 26 1311.3GFAP, PLAT, PTGDS, ABCA4, ADM
37estrogen458.3GFAP, MIF, ANGPT2, ADM, VIM, TGFB2
38vegf458.2SERPINF1, ANGPT2, MIF, VIM, ADM, TGFB2
39adenylate458.2ADM, GFAP, PLAT, HPRT1, VIM
40lipid458.2VIM, MIF, PTGDS, ADM, GFAP, ABCA4
41cycloheximide458.1PLAT, ADM, VIM, GFAP, PTGDS, TGFB2
42glutamate458.0GFAP, PLAT, TGFB2, SERPINF1, VIM, HPRT1
43glucose457.9TGFB2, PLAT, GFAP, SERPINF1, ADM, ANGPT2
44dexamethasone45 51 30 1310.9ADM, TGFB2, SERPINF1, VIM, ANGPT2, HPRT1
45matrigel457.8PLAT, GFAP, TGFB2, SERPINF1, VIM, ADM
46paraffin457.8ANGPT2, MIF, PLAT, GFAP, VIM, TGFB2
47serine457.4TGFB2, ANGPT2, PLAT, SERPINF1, MIF, GFAP
48retinoic acid45 268.2MIF, ANGPT2, ADM, VIM, SERPINF1, TGFB2
49creatinine457.1PTGDS, ADM, ANGPT2, MIF, PLAT, VIM
50cysteine457.1VIM, PLAT, HPRT1, GFAP, MIF, ANGPT2

GO Terms for genes affiliated with Macular Holes

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Cellular components related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.8TGFB2, SERPINF1, PLAT
2extracellular vesicular exosomeGO:00700628.1PLAT, HPRT1, MIF, VIM, SERPINF1
3extracellular spaceGO:00056157.9PLAT, PTGDS, TGFB2, SERPINF1, ADM, ANGPT2
4extracellular regionGO:00055767.8PTGDS, TGFB2, SERPINF1, ADM, ANGPT2, MIF

Biological processes related to Macular Holes according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:00311029.6ADM, GFAP
2prostaglandin biosynthetic processGO:00015169.5MIF, PTGDS
3Bergmann glial cell differentiationGO:00600209.5VIM, GFAP
4response to woundingGO:00096119.4GFAP, TGFB2, ADM
5astrocyte developmentGO:00140029.3VIM, GFAP
6negative regulation of neuron projection developmentGO:00109779.3VIM, GFAP
7intermediate filament organizationGO:00451099.2GFAP, VIM
8response to hypoxiaGO:00016669.0TGFB2, ADM, ANGPT2, PLAT
9response to glucocorticoidGO:00513849.0PLAT, ADM, SERPINF1, PTGDS

Molecular functions related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.3MIF, ANGPT2, ADM, TGFB2

Products for genes affiliated with Macular Holes

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Sources for Macular Holes

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet