MCID: MCL003
MIFTS: 45

Macular Holes malady

Summaries for Macular Holes

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

MalaCards: Macular Holes, also known as macular hole, is related to vitreous detachment and central retinal vein occlusion. An important gene associated with Macular Holes is TGFB2 (transforming growth factor, beta 2), and among its related pathways are Cell adhesion Plasmin signaling and Endochondral Ossification. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include retina, and related mouse phenotypes are hearing/vestibular/ear and respiratory system.

Aliases & Classifications for Macular Holes

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

macular holes 8 10 45 61
macular hole 8


External Ids:

Disease Ontology8 DOID:7633
NCIt40 C34795
MeSH35 D012167

Related Diseases for Macular Holes

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Macular Holes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1vitreous detachment31.1LHFPL5
2central retinal vein occlusion30.7VEGFA, PLAT
3proliferative diabetic retinopathy30.6TGFB2, ADM, SERPINF1, PTGDS, GFAP, MIF
4scotoma30.5ABCA4
5uveitis30.1TGFB2, SERPINF1
6proliferative vitreoretinopathy30.1GFAP, ADM, TGFB2
7alport syndrome10.5
8cystoid macular edema10.5
9coats disease10.5
10macular dystrophy10.5
11retinitis pigmentosa10.3
12diabetic macular edema10.3
13vitelliform macular dystrophy10.3
14shaken baby syndrome10.3
15stargardt disease10.1
16hole retinal cyst10.1
17gyrate atrophy10.1
18neuroretinitis10.1
19ulnar neuropathy10.1
20choroiditis10.1
21coloboma10.1
22vogt-koyanagi-harada disease10.1
23usher syndrome10.1
24exudative vitreoretinopathy10.1
25posterior uveal melanoma10.1
26osteogenesis imperfecta10.1
27n syndrome10.1
28hypertensive retinopathy10.1
29posterior uveitis10.1
30telangiectasis10.1
31vitreous disease10.1
32central serous chorioretinopathy10.1
33idiopathic edema10.1
34serpiginous choroiditis10.1
35hyperglycemia10.0SERPINF1
36psoriasis10.0ANGPT2
37liver cirrhosis10.0ADM
38glomerulonephritis10.0MIF
39bladder carcinoma10.0HPRT1
40pulmonary fibrosis10.0TGFB2
41brain edema10.0GFAP
42mixed glioma10.0GFAP
43glaucoma10.0SERPINF1, TGFB2
44osteoarthritis10.0TGFB2, ANGPT2
45pilocytic astrocytoma10.0GFAP
46cataract10.0TGFB2, SERPINF1
47cerebrovascular disease10.0ADM
48schizophrenia10.0ADM, PTGDS
49giant cell glioblastoma10.0GFAP
50primary hyperoxaluria10.0VEGFA

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to macular holes

Clinical Features for Macular Holes

Drugs & Therapeutics for Macular Holes

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Macular Holes

Drug clinical trials:

Search ClinicalTrials for Macular Holes

Search NIH Clinical Center for Macular Holes

Search CenterWatch for Macular Holes

Genetic Tests for Macular Holes

Anatomical Context for Macular Holes

Sources:
33MalaCards
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MalaCards organs/tissues related to Macular Holes:

33
Retina

Animal Models for Macular Holes or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Macular Holes

Sources:
51PubMed
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Articles related to Macular Holes:

(show top 50)    (show all 427)
idTitleAuthorsYear
1
VITREOMACULAR INTERFACE AND OUTER FOVEAL MICROSTRUCTURE IN FELLOW EYES OF PATIENTS WITH UNILATERAL MACULAR HOLES. (24280669)
2013
2
Prevalence of macular holes as cause for visual impairment. The Beijing Eye Public Healthcare Project. (23425112)
2013
3
Predicting Visual Outcome following Surgery for Idiopathic Macular Holes. (24296852)
2013
4
Surgical repair of bilateral full thickness macular holes in a patient with blue sclera secondary to osteogenesis imperfecta. (22498800)
2012
5
Understanding macular holes that develop after repair of retinal detachment. (23036545)
2012
6
Vitrectomy without face-down posturing for idiopathic macular holes. (22080914)
2012
7
Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes. (23171109)
2012
8
Idiopathic full-thickness macular holes and the vitreomacular interface: a high-resolution spectral-domain optical coherence tomography study. (22958859)
2012
9
Effect of preoperative retinal sensitivity and fixation on long-term prognosis for idiopathic macular holes. (22441811)
2012
10
Non-Foveal Macular Holes After PPV for Macular Pucker. (20844682)
2010
11
Highly viscous fluid in macular holes. (19714297)
2010
12
Cystoid foveal oedema in symptomatic inner lamellar macular holes. (19098705)
2009
13
Classification of full-thickness traumatic macular holes by optical coherence tomography. (19092730)
2009
14
Outcomes of 23- and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macular holes. (18614566)
2008
15
Accuracy of preoperative biometry in vitrectomy combined with cataract surgery for patients with epiretinal membranes and macular holes: results of a prospective controlled clinical trial. (18812129)
2008
16
Optical coherence tomography characteristics of full-thickness traumatic macular holes. (17828143)
2008
17
Management of traumatic macular holes: case report. (18797673)
2008
18
En face optical coherence tomography of macular holes in high myopia. (17001323)
2007
19
Tomographic features of spontaneous closure of full-thickness macular holes. (17295150)
2007
20
Macular holes: management 25 years ago. (16832304)
2006
21
Bilateral macular holes in usher syndrome. (16622392)
2006
22
Successful treatment of persistent macular holes using "heavy silicone oil" as intraocular tamponade. (17031291)
2006
23
Ultrahigh-resolution optical coherence tomography of surgically closed macular holes. (16769836)
2006
24
Assessing responses of the macula in patients with macular holes using a new system measuring localized visual acuity and the mfERG. (16328926)
2005
25
Disease laterality, eye dominance, and visual handicap in patients with unilateral full thickness macular holes. (12714408)
2003
26
The results of surgery on macular holes associated with rhegmatogenous retinal detachment. (12172109)
2002
27
Internal limiting membrane removal for traumatic macular holes. (11475397)
2001
28
Silicone oil tamponade to seal macular holes. (11535436)
2001
29
Scleral infolding combined with vitrectomy and gas tamponade for retinal detachment with macular holes in highly myopic eyes. (11485774)
2001
30
Time course of the size of the dark area in macular holes by scanning laser ophthalmoscopy. (10770618)
2000
31
Phaco-vitrectomy for full-thickness macular holes. (11167233)
2000
32
Estimation of the retinal nerve fibre layer thickness in the papillomacular area of long standing stage IV macular holes. (10216057)
1999
33
Vitreous surgery for traumatic macular holes. (10546936)
1999
34
The use of internal limiting membrane maculorrhexis in treatment of idiopathic macular holes. (10188368)
1998
35
Objective assessment of photoreceptor displacement and metamorphopsia: a study of macular holes. (9790627)
1998
36
Surgical management of macular holes: results using gas tamponade alone, or in combination with autologous platelet concentrate, or transforming growth factor beta 2. (9497468)
1997
37
Vision-threatening complications of surgery for full-thickness macular holes. Vitrectomy for Macular Hole Study Group. (9307639)
1997
38
Surgical treatment of full-thickness macular holes using autologous serum. (8977788)
1996
39
Current concepts in the identification and treatment of stage 2 macular holes. (10163461)
1996
40
Baseline characteristics, natural history, and risk factors to progression in eyes with stage 2 macular holes. Results from a prospective randomized clinical trial. Vitrectomy for Macular Hole Study Group. (9098283)
1995
41
Prognosis of stage 2 macular holes. (7733182)
1995
42
Clinical correlation of ultrasonographic findings in macular holes. (7573327)
1995
43
Full-thickness macular holes treated with vitrectomy and tissue glue. (7642336)
1994-1995
44
Surgical management of idiopathic macular holes. (8019120)
1994
45
Differentiating macular holes from macular pseudoholes. (8198160)
1994
46
Causative factors of retinal detachment in macular holes. (1961986)
1991
47
Idiopathic macular holes. Observations, stages of formation, and implications for surgical intervention. (3174041)
1988
48
Follow-up of macular holes. (6517439)
1984
49
Macular holes associated with central retinal vein occlusion. (5152652)
1971
50
The silver plomb method in macular holes. (5226593)
1966

Genetic Variations for Macular Holes

Expression for genes affiliated with Macular Holes

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macular Holes

Search GEO for disease gene expression data for Macular Holes.

Pathways for genes affiliated with Macular Holes

Sources:
12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Macular Holes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0PLAT
210.0PLAT
39.1GFAP, MIF, VIM

Compounds for genes affiliated with Macular Holes

Sources:
45Novoseek, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Macular Holes according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7PTGDS
2estrogen4510.5GFAP
3trifluorothymidine60 4511.1PTGDS, HPRT1
4tamoxifen45 50 29 1113.1KCNMA1
5matrigel4510.1TGFB2, VIM
6verteporfin4510.0SERPINF1, VEGFA
7heparin45 29 11 2412.9SERPINF1, VEGFA
8n-ethyl-n-nitrosourea459.8HPRT1, GFAP
9fluorescein45 1110.7VEGFA, SERPINF1, ADM
10beraprost sodium459.7PLAT, ADM
11indomethacin45 60 29 1112.7ADM, PLAT
12prostaglandin459.7VIM, PTGDS, TGFB2
13spec-t459.6ADM, GFAP, PLAT
14serine459.6MIF, HPRT1, GFAP, SERPINF1
15pge2459.5VEGFA, KCNMA1
16forskolin45 50 1111.5ADM, GFAP, VIM
17creatinine459.5ANGPT2, HPRT1, GFAP, PTGDS, TGFB2
18glyceraldehyde 3-phosphate459.5ANGPT2, HPRT1, GFAP, ADM
19hydrocortisone45 2 60 1112.4VIM, MIF, ADM, TGFB2
20streptozotocin459.3VIM, GFAP, SERPINF1, ADM
21silicone459.3GFAP, PLAT, VIM
22vitamin a45 11 2411.3VIM, HPRT1, ABCA4, TGFB2
23dexamethasone45 50 29 1112.2VEGFA, ANGPT2, GFAP, SERPINF1, TGFB2
24thymidine45 2410.1ANGPT2, MIF, HPRT1, GFAP, ADM, TGFB2
25neomycin458.8GFAP, HPRT1, VIM
26glutamate458.8GFAP, PLAT, HPRT1, KCNMA1
27potassium45 11 2410.8KCNMA1, GFAP, SERPINF1, ADM, TGFB2
28estradiol45 11 2410.8TGFB2, GFAP, KCNMA1, VIM
29testosterone45 60 11 2411.8VIM, HPRT1, GFAP, PTGDS, ADM, TGFB2
30genistein45 29 60 2 11 2413.7VIM, VEGFA, MIF, GFAP, TGFB2
31oxygen45 249.6KCNMA1, ANGPT2, GFAP, SERPINF1, ADM
32prostacyclin458.6ADM, PLAT, VEGFA, KCNMA1
33nitric oxide45 11 2410.6KCNMA1, ANGPT2, MIF, SERPINF1, ADM, TGFB2
34methionine458.4VIM, KCNMA1, MIF, GFAP, SERPINF1
35guanylate458.4VIM, KCNMA1, ANGPT2, HPRT1, SERPINF1, ADM
36histamine45 29 2410.4VIM, KCNMA1, PLAT, PTGDS, ADM
37h2o2458.3VIM, KCNMA1, ANGPT2, MIF, HPRT1, SERPINF1
38progesterone45 60 29 11 2412.3VIM, PLAT, GFAP, ADM, TGFB2
39cyclic amp45 249.3VIM, KCNMA1, GFAP, ADM, TGFB2
40isoproterenol45 119.2VIM, KCNMA1, PLAT, GFAP, ADM
41cholesterol45 29 11 2411.1KCNMA1, ABCA4, PLAT, GFAP, PTGDS, ADM
42vegf458.0VIM, VEGFA, ANGPT2, MIF, GFAP, SERPINF1
43adenylate457.9VIM, KCNMA1, HPRT1, PLAT, GFAP, ADM
44glucose457.8KCNMA1, ANGPT2, MIF, PLAT, GFAP, SERPINF1
45retinoic acid45 248.8VIM, ANGPT2, MIF, PLAT, GFAP, PTGDS
46paraffin457.7VIM, VEGFA, ANGPT2, MIF, PLAT, GFAP
47atp45 298.7VIM, KCNMA1, ANGPT2, ABCA4, GFAP, ADM
48tyrosine457.7KCNMA1, VEGFA, ANGPT2, MIF, GFAP, SERPINF1
49cysteine457.7VIM, ANGPT2, MIF, HPRT1, PLAT, GFAP
50lipid457.6VIM, KCNMA1, MIF, ABCA4, GFAP, PTGDS

GO Terms for genes affiliated with Macular Holes

Sources:
16Gene Ontology
See all sources

Cellular components related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8ANGPT2, MIF, PLAT, PTGDS, SERPINF1, ADM
2extracellular spaceGO:0056157.5TGFB2, VEGFA, ANGPT2, MIF, PLAT, PTGDS

Biological processes related to Macular Holes according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:0311029.9GFAP, ADM
2response to woundingGO:0096119.7TGFB2, ADM, GFAP
3activation of protein kinase activityGO:0321479.7TGFB2, VEGFA
4Bergmann glial cell differentiationGO:0600209.7GFAP, VIM
5prostaglandin biosynthetic processGO:0015169.6PTGDS, MIF
6response to glucocorticoid stimulusGO:0513849.5ADM, PTGDS, PLAT
7astrocyte developmentGO:0140029.5GFAP, VIM
8positive regulation of angiogenesisGO:0457669.4VEGFA, ANGPT2, ADM
9intermediate filament organizationGO:0451099.3GFAP, VIM
10blood coagulationGO:0075968.3KCNMA1, VEGFA, ANGPT2, PLAT, TGFB2
11response to hypoxiaGO:0016668.1TGFB2, KCNMA1, VEGFA, ANGPT2, PLAT, ADM

Molecular functions related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.6MIF, VEGFA
2receptor bindingGO:0051029.1TGFB2, ADM, MIF, ANGPT2

Products for genes affiliated with Macular Holes

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Macular Holes

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet