MCID: MCL003
MIFTS: 51

Macular Holes malady

Eye diseases category

Summaries for Macular Holes

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66Wikipedia, 34MalaCards
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Wikipedia:66 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

MalaCards: Macular Holes, also known as macular hole, is related to retinal detachment and vitreous detachment. An important gene associated with Macular Holes is TGFB2 (transforming growth factor, beta 2), and among its related pathways are PEDF Induced Signaling and Spinal Cord Injury. The compounds trifluorothymidine and n-ethyl-n-nitrosourea have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related mouse phenotypes are integument and hearing/vestibular/ear.

Aliases & Classifications for Macular Holes

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

macular holes 9 11 46 63
macular hole 9


External Ids:

Disease Ontology9 DOID:7633
NCIt41 C34795
MeSH36 D012167

Related Diseases for Macular Holes

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Macular Holes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1retinal detachment31.5SERPINF1, PLAT, GFAP, HPRT1, TGFB2
2vitreous detachment31.3LHFPL5
3cataract31.0TGFB2, SERPINF1
4central retinal vein occlusion30.8PLAT
5diabetic retinopathy30.7TGFB2, ANGPT2, ADM, SERPINF1
6proliferative diabetic retinopathy30.5MIF, ADM, ANGPT2, GFAP, PTGDS, TGFB2
7eye disease30.5TGFB2, ABCA4, SERPINF1
8proliferative vitreoretinopathy30.4TGFB2
9age related macular degeneration30.2PLAT
10melanoma30.1HPRT1, ANGPT2, VIM, SERPINF1, TGFB2
11retinitis11.1
12retinoschisis10.7
13myopia10.6
14retinal vein occlusion10.5
15choroiditis10.5
16alport syndrome10.5
17coats disease10.5
18cystoid macular edema10.5
19scotoma10.4
20macular dystrophy10.4
21retinitis pigmentosa10.3
22vitelliform macular dystrophy10.3
23von hippel-lindau disease10.3
24choroideremia10.3
25myotonic dystrophy10.3
26myotonic dystrophy type 110.3
27schisis association10.3
28shaken baby syndrome10.3
29stargardt disease10.1
30gyrate atrophy10.1
31posterior uveal melanoma10.1
32diabetic macular edema10.1
33hypertensive retinopathy10.1
34posterior uveitis10.1
35neuroretinitis10.1
36ulnar neuropathy10.1
37cat-scratch disease10.1
38coloboma10.1
39vogt-koyanagi-harada disease10.1
40usher syndrome10.1
41exudative vitreoretinopathy10.1
42osteogenesis imperfecta10.1
43retinopathy of prematurity10.1
44chorioretinitis10.1
45hemangioblastoma10.1
46hypertension10.1
47hypopyon10.1
48neuritis10.1
49neuropathy10.1
50optic neuritis10.1

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to macular holes

Symptoms for Macular Holes

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Drugs & Therapeutics for Macular Holes

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Macular Holes

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Anatomical Context for Macular Holes

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34MalaCards
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MalaCards organs/tissues related to Macular Holes:

34
Eye, Retina, Testes, Cortex

Animal Models for Macular Holes or affiliated genes

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Sources:
38MGI
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Publications for Macular Holes

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53PubMed
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Articles related to Macular Holes:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
2
Management of rhegmatogenous retinal detachment with coexisting macular hole: a comparison of vitrectomy with and without internal limiting membrane peeling. (23222496)
2013
3
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
4
Foveal thickness in healthy fellow eyes of patients with unilateral macular holes. (23540711)
2013
5
23- vs 20-gauge pars plana vitrectomy in combination with bimanual microincisional cataract surgery (b-MICS) for the treatment of macular hole and cataract as a one-step procedure. (23743530)
2013
6
Risk assessment of idiopathic macular holes undergoing vitrectomy with dye-assisted internal limiting membrane peeling. (23514792)
2013
7
Surgery for macular holes associated with unusual concomitant pathologies. (24082671)
2013
8
Analysis of Retinal Ganglion Cell Complex Thickness after Brilliant Blue-Assisted Vitrectomy for Idiopathic Macular Holes. (24143870)
2013
9
Episcleral macular buckling for posterior retinal detachment in silicone oil filled eyes associated with myopic macular hole. (23638417)
2013
10
INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR SURGICAL REPAIR OF MYOPIC MACULAR HOLES. (24263468)
2013
11
Spontaneous macular hole closure without posterior vitreous detachment in a patient previously treated for diabetic maculopathy. (22973980)
2013
12
Traction-induced foveal damage predisposes eyes with pre-existing posterior vitreous detachment to idiopathic macular hole formation. (22388594)
2012
13
Retinoschisis: a predictive factor in vitrectomy for macular holes without retinal detachment in highly myopic eyes. (21586755)
2012
14
SD-OCT imaging of idiopathic macular holes with spontaneous closure. (22356437)
2012
15
Full-thickness macular hole formation associated with central serous chorioretinopathy. (22729443)
2012
16
Scleral buckling in rhegmatogenous retinal detachment with concomitant full-thickness macular hole. (21726425)
2012
17
The dynamic healing process of idiopathic macular holes after surgical repair: a spectral-domain optical coherence tomography study. (21345999)
2011
18
1000 cSt silicone oil vs heavy silicone oil as intraocular tamponade in retinal detachment associated to myopic macular hole. (21080197)
2011
19
Non-Foveal Macular Holes After PPV for Macular Pucker. (20844682)
2010
20
Extended internal limiting membrane peeling in the management of unusually large macular holes. (19320310)
2009
21
Parafoveal telangiectasia (PFT) has been associated with changes in macular architecture and macular holes (lamellar and full thickness). (18185162)
2008
22
Outcomes of 23- and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macular holes. (18614566)
2008
23
Treatment of stage 2 macular hole by intravitreous injection of expansile gas and induction of posterior vitreous detachment. (17070585)
2007
24
Successful treatment of macular holes associated with peripheral retinal vascular tumours. (16710432)
2007
25
Stage 0 macular holes. (16061097)
2005
26
Foveal schisis as a cause of retinal detachment secondary to macular hole in juvenile X-linked retinoschisis. (15805920)
2005
27
Assessing responses of the macula in patients with macular holes using a new system measuring localized visual acuity and the mfERG. (16328926)
2005
28
Retinal telangiectasia in association with macular hole formation. (14716321)
2004
29
Macular holes: classification, epidemiology, natural history and treatment. (12485276)
2002
30
Bilateral macular holes: an unusual feature of alport syndrome. (12172121)
2002
31
Clinical pathogenesis of macular holes in patients affected by retinitis pigmentosa. (12708609)
2002
32
Surgery for full-thickness macular holes. (11733243)
2001
33
The visual performance and metamorphopsia of patients with macular holes. (10636412)
2000
34
Visual and anatomical results of surgery for long standing macular holes. (10655189)
2000
35
A new approach to stage 3 macular holes. (10919918)
2000
36
Time course of the size of the dark area in macular holes by scanning laser ophthalmoscopy. (10770618)
2000
37
Prevalence, correlates, and natural history of epiretinal membranes surrounding idiopathic macular holes. Virectomy for Macular Hole Study Group. (10811074)
2000
38
Morphological evaluation of full-thickness idiopathic macular holes by optical coherence tomography. (10544977)
1999
39
Anomaloscope examination in macular gliosis, macular holes and central serous choroidopathy. (9602315)
1998
40
Macular holes and PVD. (8600404)
1996
41
Autologous platelet concentrate for the treatment of full-thickness macular holes. (8543204)
1995
42
Full-thickness macular holes treated with vitrectomy and tissue glue. (7642336)
1994-1995
43
A prospective natural history study and kinetic ultrasound evaluation of idiopathic macular holes. (8302564)
1994
44
Results of surgical treatment of recent-onset full-thickness idiopathic macular holes. (7993209)
1994
45
Risk of decreased visual acuity in full-thickness idiopathic macular holes. (8250073)
1993
46
Transforming growth factor-beta 2 for the treatment of full-thickness macular holes. A prospective randomized study. (1495798)
1992
47
Causative factors of retinal detachment in macular holes. (1961986)
1991
48
Treatment of retinal detachment due to macular holes without chorio-retinal lesions. A seven-year follow-up study. (6963057)
1982
49
Macular holes associated with proliferative sickle cell retinopathy. (687199)
1978
50
The treatment of retinal detachments secondary to macular holes. (4760321)
1973

Variations for Macular Holes

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Expression for genes affiliated with Macular Holes

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macular Holes

Search GEO for disease gene expression data for Macular Holes.

Pathways for genes affiliated with Macular Holes

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Sources:
51PathCards, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Macular Holes

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46Novoseek, 62Tocris Bioscience, 3BitterDB, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR
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Compounds related to Macular Holes according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1trifluorothymidine46 6211.2HPRT1, PTGDS
2n-ethyl-n-nitrosourea469.8HPRT1, GFAP
3beraprost sodium469.6PLAT, ADM
4eosin469.6GFAP, VIM
5prostaglandin469.5PTGDS, VIM, TGFB2, ADM
6hydrocortisone46 3 62 1212.4MIF, ADM, VIM, TGFB2
7omapatrilat469.4PLAT, ADM
8catecholamine469.4ADM, VIM, MIF
9corticosterone46 62 2511.4ADM, MIF, GFAP
10s 100469.3GFAP, VIM
11glyceraldehyde 3-phosphate469.3HPRT1, ANGPT2, ADM, GFAP
12dbc-amp469.3GFAP, VIM, ADM
13neomycin469.3VIM, GFAP, HPRT1
14nitric oxide46 25 1211.2ADM, MIF, ANGPT2, SERPINF1, TGFB2
15potassium46 25 1211.2TGFB2, GFAP, SERPINF1, ADM
16guanylate469.2HPRT1, ANGPT2, ADM, VIM, SERPINF1
17streptozotocin469.1ADM, GFAP, VIM, SERPINF1
18spec-t469.1GFAP, ADM, PLAT
19p003469.0TGFB2, ADM, PLAT
20vitamin a46 25 1211.0ABCA4, HPRT1, VIM, PTGDS, TGFB2
21methionine469.0VIM, GFAP, MIF, SERPINF1
22forskolin46 52 1211.0TGFB2, GFAP, ADM, VIM
23indomethacin46 30 62 1211.9PLAT, ADM, VIM, TGFB2
24silicone468.9GFAP, VIM, PLAT
25genistein46 30 62 3 25 1213.9VIM, MIF, GFAP, TGFB2
26histamine46 30 2510.8VIM, PTGDS, ADM, PLAT
27morphine46 52 30 1211.8GFAP, HPRT1, MIF
28cyclosporin a46 30 6210.8TGFB2, ADM, ANGPT2, PLAT
29h2o2468.8MIF, ANGPT2, ADM, SERPINF1, VIM, HPRT1
30thymidine46 259.7HPRT1, TGFB2, ADM, ANGPT2, MIF, GFAP
31tamoxifen46 52 30 1211.6ADM, VIM, TGFB2, PLAT, HPRT1
32isoproterenol46 129.6PLAT, ADM, GFAP, VIM
33testosterone46 62 25 1211.6GFAP, PTGDS, HPRT1, ADM, VIM, TGFB2
34progesterone46 30 62 25 1212.3ADM, TGFB2, PLAT, VIM, GFAP
35estradiol46 25 1210.3VIM, TGFB2, MIF, PLAT, GFAP
36cholesterol46 30 25 1211.3GFAP, PLAT, PTGDS, ABCA4, ADM
37estrogen468.3GFAP, MIF, ANGPT2, ADM, VIM, TGFB2
38vegf468.2SERPINF1, ANGPT2, MIF, VIM, ADM, TGFB2
39adenylate468.2ADM, GFAP, PLAT, HPRT1, VIM
40lipid468.2VIM, MIF, PTGDS, ADM, GFAP, ABCA4
41cycloheximide468.1PLAT, ADM, VIM, GFAP, PTGDS, TGFB2
42glutamate468.0GFAP, PLAT, TGFB2, SERPINF1, VIM, HPRT1
43glucose467.9TGFB2, PLAT, GFAP, SERPINF1, ADM, ANGPT2
44dexamethasone46 52 30 1210.9ADM, TGFB2, SERPINF1, VIM, ANGPT2, HPRT1
45matrigel467.8PLAT, GFAP, TGFB2, SERPINF1, VIM, ADM
46paraffin467.8ANGPT2, MIF, PLAT, GFAP, VIM, TGFB2
47serine467.4TGFB2, ANGPT2, PLAT, SERPINF1, MIF, GFAP
48retinoic acid46 258.2MIF, ANGPT2, ADM, VIM, SERPINF1, TGFB2
49creatinine467.1PTGDS, ADM, ANGPT2, MIF, PLAT, VIM
50cysteine467.1VIM, PLAT, HPRT1, GFAP, MIF, ANGPT2

GO Terms for genes affiliated with Macular Holes

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17Gene Ontology
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Cellular components related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.8TGFB2, SERPINF1, PLAT
2extracellular vesicular exosomeGO:0700628.1PLAT, HPRT1, MIF, VIM, SERPINF1
3extracellular spaceGO:0056157.9PLAT, PTGDS, TGFB2, SERPINF1, ADM, ANGPT2
4extracellular regionGO:0055767.8PTGDS, TGFB2, SERPINF1, ADM, ANGPT2, MIF

Biological processes related to Macular Holes according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:0311029.6ADM, GFAP
2prostaglandin biosynthetic processGO:0015169.5MIF, PTGDS
3Bergmann glial cell differentiationGO:0600209.5VIM, GFAP
4response to woundingGO:0096119.4GFAP, TGFB2, ADM
5astrocyte developmentGO:0140029.3VIM, GFAP
6negative regulation of neuron projection developmentGO:0109779.3VIM, GFAP
7intermediate filament organizationGO:0451099.2GFAP, VIM
8response to hypoxiaGO:0016669.0TGFB2, ADM, ANGPT2, PLAT
9response to glucocorticoidGO:0513849.0PLAT, ADM, SERPINF1, PTGDS

Molecular functions related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3MIF, ANGPT2, ADM, TGFB2

Products for genes affiliated with Macular Holes

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Sources for Macular Holes

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet