MCID: MCL003
MIFTS: 50

Macular Holes malady

Summaries for Macular Holes

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

MalaCards: Macular Holes, also known as macular hole, is related to retinal detachment and vitreous detachment. An important gene associated with Macular Holes is TGFB2 (transforming growth factor, beta 2), and among its related pathways are Cell adhesion Plasmin signaling and Endochondral Ossification. The compounds cycloheximide and estrogen have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and cortex, and related mouse phenotypes are hearing/vestibular/ear and respiratory system.

Aliases & Classifications for Macular Holes

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
See all sources

Aliases & Descriptions:

macular holes 8 10 44 60
macular hole 8


External Ids:

Disease Ontology8 DOID:7633
NCIt39 C34795
MeSH34 D012167

Related Diseases for Macular Holes

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Macular Holes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1retinal detachment31.5HPRT1, PLAT, SERPINF1, GFAP, TGFB2, VEGFA
2vitreous detachment31.1LHFPL5
3cataract30.8SERPINF1, TGFB2
4retinal vein occlusion30.7VEGFA
5central retinal vein occlusion30.6VEGFA, PLAT
6diabetic retinopathy30.5TGFB2, VEGFA, ANGPT2, SERPINF1, ADM
7proliferative diabetic retinopathy30.5PTGDS, SERPINF1, ADM, TGFB2, GFAP, MIF
8scotoma30.4ABCA4
9macular retinal edema30.4VEGFA, SERPINF1
10eye disease30.4ABCA4, TGFB2, SERPINF1
11uveitis30.1SERPINF1, TGFB2
12retinopathy of prematurity30.1VEGFA
13hypertension30.1ADM, PLAT
14proliferative vitreoretinopathy30.1TGFB2, ADM, GFAP
15hemangioblastoma30.1GFAP, VEGFA
16age related macular degeneration30.1VEGFA, PLAT
17retinal disease30.1SERPINF1, GFAP, ABCA4, ANGPT2, VEGFA, ADM
18melanoma30.1ANGPT2, TGFB2, VIM, SERPINF1, HPRT1, VEGFA
19retinitis11.1
20retinoschisis10.7
21myopia10.6
22choroiditis10.5
23alport syndrome10.4
24cystoid macular edema10.4
25coats disease10.4
26retinitis pigmentosa10.2
27diabetic macular edema10.2
28vitelliform macular dystrophy10.2
29von hippel-lindau disease10.2
30choroideremia10.2
31myotonic dystrophy10.2
32myotonic dystrophy type 110.2
33stargardt disease10.1
34gyrate atrophy10.1
35neuroretinitis10.1
36ulnar neuropathy10.1
37cat-scratch disease10.1
38coloboma10.1
39vogt-koyanagi-harada disease10.1
40usher syndrome10.1
41exudative vitreoretinopathy10.1
42posterior uveal melanoma10.1
43osteogenesis imperfecta10.1
44hypertensive retinopathy10.1
45posterior uveitis10.1
46chorioretinitis10.1
47hypopyon10.1
48neuritis10.1
49neuropathy10.1
50optic neuritis10.1

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to macular holes

Clinical Features for Macular Holes

About this section

Drugs & Therapeutics for Macular Holes

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Macular Holes

Drug clinical trials:

Search ClinicalTrials for Macular Holes

Search NIH Clinical Center for Macular Holes

Search CenterWatch for Macular Holes

Genetic Tests for Macular Holes

About this section

Anatomical Context for Macular Holes

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Macular Holes:

32
Eye, Retina, Cortex, Testes

Animal Models for Macular Holes or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Macular Holes

About this section
Sources:
50PubMed
See all sources

Articles related to Macular Holes:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Spontaneous closure of highly myopic macular hole associated with retinal detachment. (24428948)
2014
2
Functional and structural assessment of lamellar macular holes. (23258213)
2013
3
20-gauge and 23-gauge phacovitrectomy for idiopathic macular holes: comparison of complications and long-term outcomes. (23154500)
2013
4
Management of pediatric traumatic macular holes - case report. (23898288)
2013
5
Macular hole after injection of dexamethasone intravitreal implant for macular oedema due to central retinal vein occlusion. (22863290)
2013
6
Familial trends in a population with macular holes. (22080908)
2012
7
Surgical management of macular holes - indications and complications. (23654013)
2012
8
Vitreo-papillary adhesion as a prognostic factor in pseudo- and lamellar macular holes. (22422031)
2012
9
Effect of preoperative retinal sensitivity and fixation on long-term prognosis for idiopathic macular holes. (22441811)
2012
10
Heavy versus standard silicone oil in the management of retinal detachment with macular hole in myopic eyes. (21124256)
2011
11
Natural evolution from macular retinoschisis to full-thickness macular hole in highly myopic eyes. (20829889)
2010
12
Foveal microstructure and visual acuity in surgically closed macular holes: spectral-domain optical coherence tomographic analysis. (20472291)
2010
13
A Case of Bilateral Macular Holes Showing Onset and Spontaneous Closure over Very Short Intervals. (21060772)
2010
14
Heavy silicone oil (Densiron-68) for the treatment of persistent macular holes: Densiron-68 endotamponade for persistent macular holes. (19649646)
2009
15
Surgery for bilateral macular holes. (18388963)
2009
16
Population-based incidence of macular holes. (19576500)
2009
17
Outcomes of 23- and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macular holes. (18614566)
2008
18
Macular hole following Bartonella henselae neuroretinitis. (18465733)
2008
19
Results of surgery on macular holes that develop after rhegmatogenous retinal detachment. (18227202)
2008
20
Eccentric macular holes after vitrectomy with peeling of epimacular proliferation. (17218914)
2007
21
Macular holes: the latest in current management. (16832307)
2006
22
Indocyanine green-assisted internal limiting membrane peeling for macular holes: toxicity? (16829805)
2006
23
Ultrastructure of the vitreomacular interface in full-thickness idiopathic macular holes: a consecutive analysis of 100 cases. (17056391)
2006
24
A rationale for membrane peeling in the repair of stage 4 macular holes. (15803171)
2006
25
Stage 0 macular holes. (16061097)
2005
26
Lamellar macular hole as the presenting feature in a child with Coats' disease. (16382565)
2005
27
Late reopening and spontaneous closure of previously repaired macular holes. (16139019)
2005
28
Combining phacoemulsification with vitrectomy for treatment of macular holes. (12140208)
2002
29
Surgery for full-thickness macular holes. (11733243)
2001
30
Optical coherence tomography evaluation of idiopathic macular hole treatment by gas-assisted posterior vitreous detachment. (11476695)
2001
31
Spontaneous resolution of small stage 3 and 4 full-thickness macular holes viewed by optical coherence tomography. (11321152)
2001
32
Vitrectomy for retinal detachments with both peripheral retinal breaks and macular holes. An assessment of outcome and the status of the macular hole. (11421010)
2001
33
Phaco-vitrectomy for full-thickness macular holes. (11167233)
2000
34
Diagnosis and management of macular holes. (10709588)
1999
35
Vitreous surgery for traumatic macular holes. (10546936)
1999
36
Anomaloscope examination in macular gliosis, macular holes and central serous choroidopathy. (9602315)
1998
37
Membranectomy and autologous serum for the retreatment of full-thickness macular holes. (9338673)
1997
38
Pathogenesis of idiopathic macular holes. (10168900)
1997
39
Macular holes: migratory gaps and vitreous as obstacles to glial closure. (9285223)
1997
40
Surgery for idiopathic full-thickness macular holes. (9091363)
1996
41
Optical coherence tomography of macular holes. (7777274)
1995
42
Full-thickness macular hole formation in eyes with a pre-existing complete posterior vitreous detachment. (9098265)
1995
43
Full-thickness macular holes treated with vitrectomy and tissue glue. (7642336)
1994-1995
44
A prospective natural history study and kinetic ultrasound evaluation of idiopathic macular holes. (8302564)
1994
45
Fluorescein angiographic characteristics of macular holes before and after vitrectomy with transforming growth factor beta-2. (8129001)
1994
46
More on macular holes. (7800352)
1994
47
Vitreous surgery for macular holes. (8233393)
1993
48
Best's macular dystrophy with a macular hole. (2028762)
1991
49
Early stages of macular holes. To treat or not to treat. (2383193)
1990
50
Vitrectomy for impending idiopathic macular holes. (3358429)
1988

Genetic Variations for Macular Holes

About this section

Expression for genes affiliated with Macular Holes

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Macular Holes

Search GEO for disease gene expression data for Macular Holes.

Pathways for genes affiliated with Macular Holes

About this section
Sources:
12EMD Millipore, 37NCBI BioSystems Database
See all sources

Pathways related to Macular Holes according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0PLAT
210.0PLAT
39.1GFAP, MIF, VIM

Compounds for genes affiliated with Macular Holes

About this section
Sources:
44Novoseek, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Macular Holes according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7PTGDS
2estrogen4410.5GFAP
3trifluorothymidine59 4411.1PTGDS, HPRT1
4tamoxifen44 49 28 1113.1KCNMA1
5matrigel4410.1TGFB2, VIM
6verteporfin4410.0SERPINF1, VEGFA
7heparin44 28 11 2412.9VEGFA, SERPINF1
8n-ethyl-n-nitrosourea449.8HPRT1, GFAP
9fluorescein44 1110.7VEGFA, SERPINF1, ADM
10beraprost sodium449.7PLAT, ADM
11indomethacin44 59 28 1112.7PLAT, ADM
12prostaglandin449.7VIM, PTGDS, TGFB2
13spec-t449.6ADM, PLAT, GFAP
14serine449.6SERPINF1, MIF, HPRT1, GFAP
15pge2449.5VEGFA, KCNMA1
16forskolin44 49 1111.5ADM, VIM, GFAP
17creatinine449.5TGFB2, PTGDS, GFAP, HPRT1, ANGPT2
18glyceraldehyde 3-phosphate449.5GFAP, HPRT1, ANGPT2, ADM
19hydrocortisone44 2 59 1112.4ADM, MIF, VIM, TGFB2
20streptozotocin449.3ADM, SERPINF1, GFAP, VIM
21silicone449.3VIM, GFAP, PLAT
22vitamin a44 11 2411.3HPRT1, TGFB2, ABCA4, VIM
23dexamethasone44 49 28 1112.2TGFB2, SERPINF1, GFAP, ANGPT2, VEGFA
24thymidine44 2410.1TGFB2, HPRT1, ADM, GFAP, ANGPT2, MIF
25neomycin448.8HPRT1, GFAP, VIM
26glutamate448.8KCNMA1, HPRT1, GFAP, PLAT
27potassium44 11 2410.8TGFB2, KCNMA1, SERPINF1, GFAP, ADM
28estradiol44 11 2410.8GFAP, VIM, TGFB2, KCNMA1
29testosterone44 59 11 2411.8GFAP, PTGDS, TGFB2, ADM, VIM, HPRT1
30genistein44 28 59 2 11 2413.7GFAP, MIF, TGFB2, VEGFA, VIM
31oxygen44 249.6KCNMA1, ADM, ANGPT2, GFAP, SERPINF1
32prostacyclin448.6ADM, PLAT, VEGFA, KCNMA1
33nitric oxide44 11 2410.6MIF, ADM, KCNMA1, SERPINF1, TGFB2, ANGPT2
34methionine448.4VIM, SERPINF1, GFAP, MIF, KCNMA1
35guanylate448.4VIM, KCNMA1, ANGPT2, HPRT1, ADM, SERPINF1
36histamine44 28 2410.4KCNMA1, VIM, ADM, PTGDS, PLAT
37h2o2448.3HPRT1, VIM, ANGPT2, SERPINF1, KCNMA1, MIF
38progesterone44 59 28 11 2412.3TGFB2, ADM, GFAP, PLAT, VIM
39cyclic amp44 249.3TGFB2, ADM, GFAP, KCNMA1, VIM
40isoproterenol44 119.2ADM, PLAT, GFAP, KCNMA1, VIM
41cholesterol44 28 11 2411.1KCNMA1, PLAT, PTGDS, ABCA4, ADM, GFAP
42vegf448.0ADM, VIM, VEGFA, TGFB2, ANGPT2, MIF
43adenylate447.9VIM, PLAT, ADM, KCNMA1, HPRT1, GFAP
44glucose447.8TGFB2, ADM, GFAP, PLAT, MIF, ANGPT2
45retinoic acid44 248.8GFAP, ANGPT2, MIF, PLAT, VIM, PTGDS
46paraffin447.7VEGFA, GFAP, TGFB2, PLAT, MIF, ADM
47atp44 288.7VIM, KCNMA1, ANGPT2, ABCA4, ADM, GFAP
48tyrosine447.7KCNMA1, VEGFA, MIF, GFAP, ANGPT2, TGFB2
49cysteine447.7VIM, HPRT1, MIF, PLAT, GFAP, SERPINF1
50lipid447.6ADM, VIM, KCNMA1, MIF, GFAP, PTGDS

GO Terms for genes affiliated with Macular Holes

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8VEGFA, ANGPT2, MIF, PLAT, PTGDS, SERPINF1
2extracellular spaceGO:0056157.5VEGFA, ANGPT2, MIF, PLAT, PTGDS, SERPINF1

Biological processes related to Macular Holes according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:0311029.9GFAP, ADM
2response to woundingGO:0096119.7TGFB2, ADM, GFAP
3activation of protein kinase activityGO:0321479.7TGFB2, VEGFA
4Bergmann glial cell differentiationGO:0600209.7GFAP, VIM
5prostaglandin biosynthetic processGO:0015169.6PTGDS, MIF
6response to glucocorticoid stimulusGO:0513849.5ADM, PTGDS, PLAT
7astrocyte developmentGO:0140029.5GFAP, VIM
8positive regulation of angiogenesisGO:0457669.4VEGFA, ANGPT2, ADM
9intermediate filament organizationGO:0451099.3GFAP, VIM
10blood coagulationGO:0075968.3KCNMA1, VEGFA, ANGPT2, PLAT, TGFB2
11response to hypoxiaGO:0016668.1TGFB2, KCNMA1, VEGFA, ANGPT2, PLAT, ADM

Molecular functions related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemoattractant activityGO:0420569.6MIF, VEGFA
2receptor bindingGO:0051029.1TGFB2, ADM, MIF, ANGPT2

Products for genes affiliated with Macular Holes

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Macular Holes

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet