MCID: MCL003
MIFTS: 51

Macular Holes malady

Eye diseases category
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Summaries for Macular Holes

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65Wikipedia, 33MalaCards
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Wikipedia:65 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

MalaCards: Macular Holes, also known as macular hole, is related to retinal detachment and vitreous detachment. An important gene associated with Macular Holes is TGFB2 (transforming growth factor, beta 2), and among its related pathways are PEDF Induced Signaling and Spinal Cord Injury. The compounds trifluorothymidine and n-ethyl-n-nitrosourea have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related mouse phenotypes are integument and hearing/vestibular/ear.

Aliases & Classifications for Macular Holes

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

macular holes 8 10 45 62
macular hole 8


External Ids:

Disease Ontology8 DOID:7633
NCIt40 C34795
MeSH35 D012167

Related Diseases for Macular Holes

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17GeneCards, 18GeneDecks
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Diseases related to Macular Holes via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 105)
idRelated DiseaseScoreTop Affiliating Genes
1retinal detachment31.5SERPINF1, PLAT, GFAP, HPRT1, TGFB2
2vitreous detachment31.3LHFPL5
3cataract31.0TGFB2, SERPINF1
4central retinal vein occlusion30.8PLAT
5diabetic retinopathy30.7TGFB2, ANGPT2, ADM, SERPINF1
6proliferative diabetic retinopathy30.5MIF, ADM, ANGPT2, GFAP, PTGDS, TGFB2
7eye disease30.5TGFB2, ABCA4, SERPINF1
8proliferative vitreoretinopathy30.4TGFB2
9age related macular degeneration30.2PLAT
10melanoma30.1HPRT1, ANGPT2, VIM, SERPINF1, TGFB2
11retinitis11.1
12retinoschisis10.7
13myopia10.6
14retinal vein occlusion10.5
15choroiditis10.5
16alport syndrome10.5
17coats disease10.5
18cystoid macular edema10.5
19scotoma10.4
20macular dystrophy10.4
21retinitis pigmentosa10.3
22vitelliform macular dystrophy10.3
23von hippel-lindau disease10.3
24choroideremia10.3
25myotonic dystrophy10.3
26myotonic dystrophy type 110.3
27schisis association10.3
28shaken baby syndrome10.3
29stargardt disease10.1
30gyrate atrophy10.1
31posterior uveal melanoma10.1
32diabetic macular edema10.1
33hypertensive retinopathy10.1
34posterior uveitis10.1
35neuroretinitis10.1
36ulnar neuropathy10.1
37cat-scratch disease10.1
38coloboma10.1
39vogt-koyanagi-harada disease10.1
40usher syndrome10.1
41exudative vitreoretinopathy10.1
42osteogenesis imperfecta10.1
43retinopathy of prematurity10.1
44chorioretinitis10.1
45hemangioblastoma10.1
46hypertension10.1
47hypopyon10.1
48neuritis10.1
49neuropathy10.1
50optic neuritis10.1

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to macular holes

Symptoms for Macular Holes

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Drugs & Therapeutics for Macular Holes

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Macular Holes

Search NIH Clinical Center for Macular Holes

Genetic Tests for Macular Holes

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Anatomical Context for Macular Holes

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33MalaCards
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MalaCards organs/tissues related to Macular Holes:

33
Eye, Retina, Testes, Cortex

Animal Models for Macular Holes or affiliated genes

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37MGI
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Publications for Macular Holes

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52PubMed
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Articles related to Macular Holes:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
2
Management of rhegmatogenous retinal detachment with coexisting macular hole: a comparison of vitrectomy with and without internal limiting membrane peeling. (23222496)
2013
3
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
4
Foveal thickness in healthy fellow eyes of patients with unilateral macular holes. (23540711)
2013
5
23- vs 20-gauge pars plana vitrectomy in combination with bimanual microincisional cataract surgery (b-MICS) for the treatment of macular hole and cataract as a one-step procedure. (23743530)
2013
6
Risk assessment of idiopathic macular holes undergoing vitrectomy with dye-assisted internal limiting membrane peeling. (23514792)
2013
7
Surgery for macular holes associated with unusual concomitant pathologies. (24082671)
2013
8
Analysis of Retinal Ganglion Cell Complex Thickness after Brilliant Blue-Assisted Vitrectomy for Idiopathic Macular Holes. (24143870)
2013
9
Episcleral macular buckling for posterior retinal detachment in silicone oil filled eyes associated with myopic macular hole. (23638417)
2013
10
INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR SURGICAL REPAIR OF MYOPIC MACULAR HOLES. (24263468)
2013
11
Spontaneous macular hole closure without posterior vitreous detachment in a patient previously treated for diabetic maculopathy. (22973980)
2013
12
Traction-induced foveal damage predisposes eyes with pre-existing posterior vitreous detachment to idiopathic macular hole formation. (22388594)
2012
13
Retinoschisis: a predictive factor in vitrectomy for macular holes without retinal detachment in highly myopic eyes. (21586755)
2012
14
SD-OCT imaging of idiopathic macular holes with spontaneous closure. (22356437)
2012
15
Full-thickness macular hole formation associated with central serous chorioretinopathy. (22729443)
2012
16
Scleral buckling in rhegmatogenous retinal detachment with concomitant full-thickness macular hole. (21726425)
2012
17
The dynamic healing process of idiopathic macular holes after surgical repair: a spectral-domain optical coherence tomography study. (21345999)
2011
18
1000 cSt silicone oil vs heavy silicone oil as intraocular tamponade in retinal detachment associated to myopic macular hole. (21080197)
2011
19
Non-Foveal Macular Holes After PPV for Macular Pucker. (20844682)
2010
20
Extended internal limiting membrane peeling in the management of unusually large macular holes. (19320310)
2009
21
Parafoveal telangiectasia (PFT) has been associated with changes in macular architecture and macular holes (lamellar and full thickness). (18185162)
2008
22
Outcomes of 23- and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macular holes. (18614566)
2008
23
Treatment of stage 2 macular hole by intravitreous injection of expansile gas and induction of posterior vitreous detachment. (17070585)
2007
24
Successful treatment of macular holes associated with peripheral retinal vascular tumours. (16710432)
2007
25
Stage 0 macular holes. (16061097)
2005
26
Foveal schisis as a cause of retinal detachment secondary to macular hole in juvenile X-linked retinoschisis. (15805920)
2005
27
Assessing responses of the macula in patients with macular holes using a new system measuring localized visual acuity and the mfERG. (16328926)
2005
28
Retinal telangiectasia in association with macular hole formation. (14716321)
2004
29
Macular holes: classification, epidemiology, natural history and treatment. (12485276)
2002
30
Bilateral macular holes: an unusual feature of alport syndrome. (12172121)
2002
31
Clinical pathogenesis of macular holes in patients affected by retinitis pigmentosa. (12708609)
2002
32
Surgery for full-thickness macular holes. (11733243)
2001
33
The visual performance and metamorphopsia of patients with macular holes. (10636412)
2000
34
Visual and anatomical results of surgery for long standing macular holes. (10655189)
2000
35
A new approach to stage 3 macular holes. (10919918)
2000
36
Time course of the size of the dark area in macular holes by scanning laser ophthalmoscopy. (10770618)
2000
37
Prevalence, correlates, and natural history of epiretinal membranes surrounding idiopathic macular holes. Virectomy for Macular Hole Study Group. (10811074)
2000
38
Morphological evaluation of full-thickness idiopathic macular holes by optical coherence tomography. (10544977)
1999
39
Anomaloscope examination in macular gliosis, macular holes and central serous choroidopathy. (9602315)
1998
40
Macular holes and PVD. (8600404)
1996
41
Autologous platelet concentrate for the treatment of full-thickness macular holes. (8543204)
1995
42
Full-thickness macular holes treated with vitrectomy and tissue glue. (7642336)
1994-1995
43
A prospective natural history study and kinetic ultrasound evaluation of idiopathic macular holes. (8302564)
1994
44
Results of surgical treatment of recent-onset full-thickness idiopathic macular holes. (7993209)
1994
45
Risk of decreased visual acuity in full-thickness idiopathic macular holes. (8250073)
1993
46
Transforming growth factor-beta 2 for the treatment of full-thickness macular holes. A prospective randomized study. (1495798)
1992
47
Causative factors of retinal detachment in macular holes. (1961986)
1991
48
Treatment of retinal detachment due to macular holes without chorio-retinal lesions. A seven-year follow-up study. (6963057)
1982
49
Macular holes associated with proliferative sickle cell retinopathy. (687199)
1978
50
The treatment of retinal detachments secondary to macular holes. (4760321)
1973

Variations for Macular Holes

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Expression for genes affiliated with Macular Holes

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Macular Holes

Search GEO for disease gene expression data for Macular Holes.

Pathways for genes affiliated with Macular Holes

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Sources:
50PathCards, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database
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Compounds for genes affiliated with Macular Holes

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45Novoseek, 61Tocris Bioscience, 3BitterDB, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR
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Compounds related to Macular Holes according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1trifluorothymidine45 6111.2HPRT1, PTGDS
2n-ethyl-n-nitrosourea459.8HPRT1, GFAP
3beraprost sodium459.6PLAT, ADM
4eosin459.6GFAP, VIM
5prostaglandin459.5PTGDS, VIM, TGFB2, ADM
6hydrocortisone45 3 61 1112.4MIF, ADM, VIM, TGFB2
7omapatrilat459.4PLAT, ADM
8catecholamine459.4ADM, VIM, MIF
9corticosterone45 61 2411.4ADM, MIF, GFAP
10s 100459.3GFAP, VIM
11glyceraldehyde 3-phosphate459.3HPRT1, ANGPT2, ADM, GFAP
12dbc-amp459.3GFAP, VIM, ADM
13neomycin459.3VIM, GFAP, HPRT1
14nitric oxide45 24 1111.2ADM, MIF, ANGPT2, SERPINF1, TGFB2
15potassium45 24 1111.2TGFB2, GFAP, SERPINF1, ADM
16guanylate459.2HPRT1, ANGPT2, ADM, VIM, SERPINF1
17streptozotocin459.1ADM, GFAP, VIM, SERPINF1
18spec-t459.1GFAP, ADM, PLAT
19p003459.0TGFB2, ADM, PLAT
20vitamin a45 24 1111.0ABCA4, HPRT1, VIM, PTGDS, TGFB2
21methionine459.0VIM, GFAP, MIF, SERPINF1
22forskolin45 51 1111.0TGFB2, GFAP, ADM, VIM
23indomethacin45 29 61 1111.9PLAT, ADM, VIM, TGFB2
24silicone458.9GFAP, VIM, PLAT
25genistein45 29 61 3 24 1113.9VIM, MIF, GFAP, TGFB2
26histamine45 29 2410.8VIM, PTGDS, ADM, PLAT
27morphine45 51 29 1111.8GFAP, HPRT1, MIF
28cyclosporin a45 29 6110.8TGFB2, ADM, ANGPT2, PLAT
29h2o2458.8MIF, ANGPT2, ADM, SERPINF1, VIM, HPRT1
30thymidine45 249.7HPRT1, TGFB2, ADM, ANGPT2, MIF, GFAP
31tamoxifen45 51 29 1111.6ADM, VIM, TGFB2, PLAT, HPRT1
32isoproterenol45 119.6PLAT, ADM, GFAP, VIM
33testosterone45 61 24 1111.6GFAP, PTGDS, HPRT1, ADM, VIM, TGFB2
34progesterone45 29 61 24 1112.3ADM, TGFB2, PLAT, VIM, GFAP
35estradiol45 24 1110.3VIM, TGFB2, MIF, PLAT, GFAP
36cholesterol45 29 24 1111.3GFAP, PLAT, PTGDS, ABCA4, ADM
37estrogen458.3GFAP, MIF, ANGPT2, ADM, VIM, TGFB2
38vegf458.2SERPINF1, ANGPT2, MIF, VIM, ADM, TGFB2
39adenylate458.2ADM, GFAP, PLAT, HPRT1, VIM
40lipid458.2VIM, MIF, PTGDS, ADM, GFAP, ABCA4
41cycloheximide458.1PLAT, ADM, VIM, GFAP, PTGDS, TGFB2
42glutamate458.0GFAP, PLAT, TGFB2, SERPINF1, VIM, HPRT1
43glucose457.9TGFB2, PLAT, GFAP, SERPINF1, ADM, ANGPT2
44dexamethasone45 51 29 1110.9ADM, TGFB2, SERPINF1, VIM, ANGPT2, HPRT1
45matrigel457.8PLAT, GFAP, TGFB2, SERPINF1, VIM, ADM
46paraffin457.8ANGPT2, MIF, PLAT, GFAP, VIM, TGFB2
47serine457.4TGFB2, ANGPT2, PLAT, SERPINF1, MIF, GFAP
48retinoic acid45 248.2MIF, ANGPT2, ADM, VIM, SERPINF1, TGFB2
49creatinine457.1PTGDS, ADM, ANGPT2, MIF, PLAT, VIM
50cysteine457.1VIM, PLAT, HPRT1, GFAP, MIF, ANGPT2

GO Terms for genes affiliated with Macular Holes

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16Gene Ontology
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Cellular components related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310128.8TGFB2, SERPINF1, PLAT
2extracellular vesicular exosomeGO:0700628.1PLAT, HPRT1, MIF, VIM, SERPINF1
3extracellular spaceGO:0056157.9PLAT, PTGDS, TGFB2, SERPINF1, ADM, ANGPT2
4extracellular regionGO:0055767.8PTGDS, TGFB2, SERPINF1, ADM, ANGPT2, MIF

Biological processes related to Macular Holes according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:0311029.6ADM, GFAP
2prostaglandin biosynthetic processGO:0015169.5MIF, PTGDS
3Bergmann glial cell differentiationGO:0600209.5VIM, GFAP
4response to woundingGO:0096119.4GFAP, TGFB2, ADM
5astrocyte developmentGO:0140029.3VIM, GFAP
6negative regulation of neuron projection developmentGO:0109779.3VIM, GFAP
7intermediate filament organizationGO:0451099.2GFAP, VIM
8response to hypoxiaGO:0016669.0TGFB2, ADM, ANGPT2, PLAT
9response to glucocorticoidGO:0513849.0PLAT, ADM, SERPINF1, PTGDS

Molecular functions related to Macular Holes according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051029.3MIF, ANGPT2, ADM, TGFB2

Products for genes affiliated with Macular Holes

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Sources for Macular Holes

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet