MCID: MCL003
MIFTS: 41

Macular Holes malady

Categories: Eye diseases

Aliases & Classifications for Macular Holes

Aliases & Descriptions for Macular Holes:

Name: Macular Holes 12 52 14 69
Macular Hole 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:7633
MeSH 42 D012167
NCIt 47 C34795
SNOMED-CT 64 193388002 232006002
UMLS 69 C0024441

Summaries for Macular Holes

MalaCards based summary : Macular Holes, also known as macular hole, is related to retinal disease and retinitis. An important gene associated with Macular Holes is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are AGE-RAGE signaling pathway in diabetic complications and Rheumatoid arthritis. The drugs Ranibizumab and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related phenotypes are immune system and nervous system

Wikipedia : 71 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

Related Diseases for Macular Holes

Diseases related to Macular Holes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
id Related Disease Score Top Affiliating Genes
1 retinal disease 10.9
2 retinitis 10.8
3 retinal detachment 10.7
4 retinoschisis 10.4
5 vitreous detachment 10.3
6 myopia 10.3
7 cataract 10.2
8 submucous uterine fibroid 10.1 ANGPT2 VEGFA
9 hypersensitivity syndrome, carbamazepine-induced 10.1 ANGPT2 VEGFA
10 radiation induced angiosarcoma of the breast 10.1 ANGPT2 VEGFA
11 retinal vein occlusion 10.1
12 choroiditis 10.1
13 bipolar i disorder 10.1 ANGPT2 VEGFA
14 congenital toxoplasmosis 10.1 SERPINF1 VEGFA
15 alport syndrome 10.1
16 localized junctional epidermolysis bullosa, non-herlitz type 10.1 ANGPT2 VEGFA
17 hyperinsulinism 10.1 ANGPT2 TGFB2 VEGFA
18 vernal conjunctivitis 10.1 ANGPT2 SERPINF1 VEGFA
19 coats disease 10.1
20 central retinal vein occlusion 10.1
21 albinism, oculocutaneous, type ib 10.1 ANGPT2 SERPINF1 VEGFA
22 citrullinemia, type ii, neonatal-onset 10.0 ANGPT2 SERPINF1 VEGFA
23 angular blepharoconjunctivitis 10.0 SERPINF1 VEGFA
24 human venous malformation 10.0 ANGPT2 TGFB2 VEGFA
25 neuropathy 10.0
26 congenital ichthyosiform erythroderma 10.0 RS1 TGFB2 VEGFA
27 upper respiratory tract disease 10.0 RS1 TGFB2 VEGFA
28 biemond syndrome ii 10.0 RS1 VEGFA
29 anterograde amnesia 10.0 RS1 SERPINF1 VEGFA
30 perianal hematoma 10.0 KCNMA1 LHFPL5 RS1
31 maxillary sinus cancer 10.0 KCNMA1 RS1
32 scotoma 9.9
33 athabaskan brainstem dysgenesis syndrome 9.9 KCNMA1 RS1 VEGFA
34 albinism, oculocutaneous, type ia 9.9 ADM CCL2 TGFB2
35 pyriform sinus cancer 9.9 CCL2 SERPINF1 VEGFA
36 scar contracture 9.9 CCL2 SERPINF1 VEGFA
37 choroideremia 9.9
38 stargardt disease 9.9
39 retinitis pigmentosa 9.9
40 vitelliform macular dystrophy 9.9
41 neuroretinitis 9.9
42 vogt-koyanagi-harada disease 9.9
43 eye disease 9.9
44 chorioretinitis 9.9
45 myotonic dystrophy 9.9
46 schisis association 9.9
47 shaken baby syndrome 9.9
48 ulcerative proctitis 9.8 CCL2 VEGFA
49 multilocular clear cell renal cell carcinoma 9.8 KCNMA1 RS1 SERPINF1 VEGFA
50 thymus adenosquamous carcinoma 9.8 CCL2 SERPINF1 VEGFA

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to Macular Holes

Symptoms & Phenotypes for Macular Holes

MGI Mouse Phenotypes related to Macular Holes:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.56 ADM ANGPT2 CCL2 MIF PTGDS SERPINF1
2 nervous system MP:0003631 9.23 TGFB2 VEGFA KCNMA1 LHFPL5 MIF PTGDS

Drugs & Therapeutics for Macular Holes

Drugs for Macular Holes (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Phase 2 347396-82-1 459903
2
Bevacizumab Approved, Investigational Phase 4 216974-75-3
3
Verteporfin Approved, Investigational Phase 4 129497-78-5
4 Angiogenesis Inhibitors Phase 4,Phase 2
5 Angiogenesis Modulating Agents Phase 4,Phase 2
6 Mitogens Phase 4,Phase 2
7 Endothelial Growth Factors Phase 4
8 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1
9 Dermatologic Agents Phase 4
10 Photosensitizing Agents Phase 4
11
Lutein Approved, Nutraceutical Phase 3 127-40-2 6433159 5368396
12 Plasminogen Phase 3,Phase 2
13 Fibrinolytic Agents Phase 3,Phase 2
14 Tetrahydrozoline Phase 2
15 Ophthalmic Solutions Phase 2,Phase 1
16
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
17
Tropicamide Approved Phase 1 1508-75-4 5593
18 glucocorticoids Phase 1
19 Hormone Antagonists Phase 1
20 Hormones Phase 1
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
22 Anti-Inflammatory Agents Phase 1
23 Dexamethasone acetate Phase 1 1177-87-3
24
protease inhibitors Phase 1
25 Gastrointestinal Agents Phase 1
26 HIV Protease Inhibitors Phase 1
27 Dexamethasone 21-phosphate Phase 1
28 Peripheral Nervous System Agents Phase 1
29 Antiemetics Phase 1
30 BB 1101 Phase 1
31 Autonomic Agents Phase 1
32 Antineoplastic Agents, Hormonal Phase 1
33
Triamcinolone Approved, Vet_approved 124-94-7 31307
34
Temazepam Approved 846-50-4 5391
35
Timolol Approved 26839-75-8 33624 5478
36
Dorzolamide Approved 120279-96-1 3154 5284549
37
Benzocaine Approved 1994-09-7, 94-09-7 2337
38
Menthol Approved 2216-51-5 16666
39
Dipivefrin Approved 52365-63-6 3105
40
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741 24759
41
Povidone-iodine Approved 25655-41-8
42
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
43 tannic acid Approved, Nutraceutical
44
Diminazene Experimental 536-71-0
45 triamcinolone acetonide
46 GABA Agents
47 GABA Modulators
48 Neurotransmitter Agents
49 Tranquilizing Agents
50 Triamcinolone diacetate

Interventional clinical trials:

(show top 50) (show all 104)
id Name Status NCT ID Phase
1 Effects of Different Area of Internal Limiting Membrane Peeling (ILM) Peeling on Anatomical Outcomes in Macular Hole Surgery Completed NCT02930369 Phase 4
2 Assessment of Patients Treated With JETREA® for Vitreomacular Traction Completed NCT02035748 Phase 4
3 Ocriplasmin for Vitreomacular Traction/Symptomatic Vitreomacular Adhesion Completed NCT02322229 Phase 4
4 Study of Surgery in Patients With Idiopathic Macular Hole Recruiting NCT02905409 Phase 4
5 Cohort Study of the Clinical Course of Macular Diseases in Kagawa Recruiting NCT02321267 Phase 4
6 TF (SENSIMED Triggerfish) in Intraocular Anti-VEGF (Vascular Endothelial Growth Factor) Injection Terminated NCT01983579 Phase 4
7 Brilliant Blue Versus Indocyanine Green Unknown status NCT01083004 Phase 3
8 Safety and Efficacy of Double Staining With Brilliant Blue G for Macular Surgery Unknown status NCT01820520 Phase 3
9 Ocriplasmin for Treatment for Symptomatic Vitreomacular Adhesion Including Macular Hole Completed NCT01429441 Phase 3
10 Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy Completed NCT01627977 Phase 3
11 Trial of Microplasmin Intravitreal Injection for Non-Surgical Treatment of Focal Vitreomacular Adhesion. The MIVI-TRUST (TG-MV-007) Trial. Completed NCT00798317 Phase 3
12 A Phase III Study of A01016 in Subjects With Symptomatic Vitreomacular Adhesion Completed NCT01889251 Phase 3
13 A Safety And Efficacy Study Of Alg-1001 In Human Subjects With Symptomatic Focal Vitreomacular Adhesion Completed NCT02153476 Phase 2
14 Intravitreal Microplasmin in Patients Undergoing Surgical Vitrectomy Completed NCT00123279 Phase 2
15 Analysis of Aqueous and Vitreous Humor Recruiting NCT02067013 Phase 2
16 Study of OT-551 Eye Drops to Prevent or Delay Progression of Nuclear Cataracts Following Vitreous Removal Terminated NCT00333060 Phase 2
17 PK Study of Iontophoretic Dexamethasone Phosphate Ophthalmic Solution in Patients Undergoing Vitrectomy Completed NCT02644694 Phase 1
18 Clinical Trial of Intravitreal Injection of Autologous Bone Marrow Stem Cells in Patients With Retinitis Pigmentosa Completed NCT02280135 Phase 1
19 Inverted ILM Repositioning as Treatment for Full Thickness Macular Holes Unknown status NCT01228188
20 Early Vitrectomy for Impending Macular Hole Unknown status NCT01121965
21 Macular Hole Surgery With and Without Internal Limiting Membrane Peeling:A Systematic Review and Meta-analysis Unknown status NCT01687829
22 The Intravitreal Autologous Platelet Concentrate Injection as an Adjunct of Vitrectomy for the Treatment of Refractory Macular Holes Unknown status NCT02081170
23 Early Vitrectomy for Macular Tractional Maculopathy Unknown status NCT01121978
24 Comparison of Postoperative Aqueous Flare After 20G Versus 23G Pars Plana Vitrectomy Unknown status NCT01969929
25 Prognostic Factors for Visual Improvement in Patients Undergoing Intravitreal Ranibizumab for Retinal Vein Occlusion Unknown status NCT02144662
26 Prophylactic Laser Photocoagulation and Vitrectomy for Acute Retinal Necrosis Unknown status NCT02222857
27 Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel Unknown status NCT00892619
28 Observation of Recovery of Foveal Cone Microstructures After Macular Hole Surgery Completed NCT01306487
29 Optical Coherence Tomography-based Positioning for Macular Hole Surgery Completed NCT02650739
30 Foveal Cone Outer Segment Resumption to Predict Visual Recovery After Macular Hole Surgery Completed NCT01381965
31 Alleviated Positioning for Small Macular Holes Completed NCT00190164
32 Preoperative Progression of Macular Holes Completed NCT02203929
33 Trial of Prognostic Factors and Surgical Methods for the Treatment of Idiopathic Macular Holes Completed NCT00302328
34 Air Tamponade in Macular Hole Surgery Completed NCT01680068
35 Postoperative Positioning After Surgery for Macular Holes Completed NCT01974310
36 Outcome of Idiopathic Macular Hole Completed NCT00941291
37 Comparative Study Between Early Vitrectomy and Observation for Spontaneous Closure of Traumatic Macular Hole Completed NCT01509092
38 Unveiling Preclinical Idiopathic Macular Hole Formation Completed NCT02180633
39 Air Tamponade in Macular Holes < 400 μm Completed NCT02028481
40 Brillant Blue Versus Indocyanine Green for Macular Hole Surgery Completed NCT00757471
41 High Myopia Macular Hole and Retinal Detachment Treated With Double ILM Flaps Completed NCT03174639
42 Fundus Autofluorescence After Macular Hole Surgery Completed NCT02628262
43 Optical Coherence Tomography in Gas-filled Eyes Completed NCT01266746
44 Macular Hole in Diabetic Retinopathy Completed NCT00737074
45 Microperimetry and Optical Coherence Tomography (OCT) in Idiopathic Macular Hole Completed NCT01757600
46 Combined Versus Successive Macular Hole and Cataract Surgery Completed NCT01069029
47 Elongation of Foveal Tissue After Macular Hole Surgery Completed NCT01471912
48 Macular Hole Reopening Completed NCT00927628
49 An Objective Evaluation of Postoperative Positioning in Macular Hole Surgery Completed NCT02011165
50 Internal Limiting Membrane Peeling for Large Macular Holes Completed NCT00190190

Search NIH Clinical Center for Macular Holes

Genetic Tests for Macular Holes

Anatomical Context for Macular Holes

MalaCards organs/tissues related to Macular Holes:

39
Eye, Retina, Testes, Cortex

Publications for Macular Holes

Articles related to Macular Holes:

(show top 50) (show all 641)
id Title Authors Year
1
Macular hole in Stargardt disease: Clinical and ultra-structural observation. ( 28121212 )
2017
2
Monitoring macular pigment changes in macular holes using fluorescence lifetime imaging ophthalmoscopy. ( 27775222 )
2016
3
EPIRETINAL MEMBRANE-INDUCED FULL-THICKNESS MACULAR HOLES: The Clinical Features and Surgical Outcomes. ( 26934453 )
2016
4
Long-term Follow-up and Outcomes in Traumatic Macular Holes. ( 27079301 )
2016
5
Inverted Internal Limiting Membrane Insertion for Macular Hole-Associated Retinal Detachment in High Myopia. ( 27174666 )
2016
6
Surgical outcomes of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation. ( 27647708 )
2016
7
Aniseikonia and Foveal Microstructure in Patients with Idiopathic Macular Hole. ( 27406114 )
2016
8
Lamellar macular hole in X linked retinoschisis. ( 27170611 )
2016
9
Internal limiting membrane transplantation for unclosed and large macular holes. ( 27520464 )
2016
10
Real-life experience with intravitreal ocriplasmin on vitreomacular traction and full-thickness macular holes. ( 27502626 )
2016
11
Bilateral macular holes and a new onset vitelliform lesion in Best disease. ( 27031371 )
2016
12
Free ILM patch transplantation for recalcitrant macular holes; should we save some internal limiting membrane for later? ( 27614463 )
2016
13
Anatomical and Functional Results of Lamellar Macular Holes Surgery. ( 27116504 )
2016
14
Role of lamellar hole-associated epiretinal proliferation in lamellar macular holes. ( 27889502 )
2016
15
RECURRENT MACULAR HOLES IN THE ERA OF SMALL-GAUGE VITRECTOMY: A Review of Incidence, Risk Factors, and Outcomes. ( 27627748 )
2016
16
PREDICTION OF MORPHOLOGIC DETERIORATION IN PATIENTS WITH LAMELLAR MACULAR HOLES. ( 26934452 )
2016
17
Viscoat Assisted Inverted Internal Limiting Membrane Flap Technique for Large Macular Holes Associated with High Myopia. ( 27047686 )
2016
18
SURGICAL TREATMENT OF A MACULAR HOLE IN X-LINKED RETINOSCHISIS. ( 27203560 )
2016
19
Modification of the Inverted Internal Limiting Membrane Flap Technique for the Treatment of Chronic and Large Macular Holes. ( 26696312 )
2016
20
Nonarteritic anterior ischemic optic neuropathy following pars plana vitrectomy for macular hole treatment: case report. ( 27982219 )
2016
21
Internal limiting membrane translocation for refractory macular holes. ( 27146153 )
2016
22
Autologous Neurosensory Retinal Free Flap for Closure of Refractory Myopic Macular Holes. ( 26720054 )
2016
23
CORRELATIONS BETWEEN PREOPERATIVE RETINAL PIGMENT EPITHELIAL PROTRUSIONS AND POSTOPERATIVE OUTCOMES IN EYES WITH IDIOPATHIC MACULAR HOLES. ( 27429383 )
2016
24
Vitreoretinal traction and lamellar macular holes associated with cicatricial toxoplasmic retinochoroiditis: case series report. ( 27312206 )
2016
25
Management of Challenging Macular Holes: Current Concepts and New Surgical Techniques. ( 27327279 )
2016
26
RAPID MACULAR HOLE FORMATION, SPONTANEOUS CLOSURE, AND REOPENING AFTER PARS PLANA VITRECTOMY FOR MACULA-SPARING RETINAL DETACHMENT. ( 27145172 )
2016
27
Inverted Internal Limiting Membrane Flap For Large Traumatic Macular Holes. ( 26817894 )
2016
28
THE ASSOCIATION OF EPIRETINAL MEMBRANE WITH MACULAR HOLE FORMATION AFTER RHEGMATOGENOUS RETINAL DETACHMENT REPAIR. ( 27632712 )
2016
29
RISK FACTORS FOR DEVELOPMENT OF MACULAR HOLE RETINAL DETACHMENT AFTER PARS PLANA VITRECTOMY FOR PATHOLOGIC MYOPIC FOVEOSCHISIS. ( 27652914 )
2016
30
Vitreal Cytokine Profile Differences Between Eyes With Epiretinal Membranes or Macular Holes. ( 27893098 )
2016
31
Size and vitreomacular attachment of primary full-thickness macular holes. ( 27913441 )
2016
32
INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR MACULAR HOLES IN HIGH MYOPIA WITH AXIAL LENGTH a8Y30 mm. ( 26966865 )
2016
33
Inverted Internal Limiting Membrane Flap Technique for Repair of Large Macular Holes: A Short-term Follow-up of Anatomical and Functional Outcomes. ( 26904983 )
2016
34
Leber Hereditary Optic Neuropathy Associated with Bilateral Macular Holes. ( 27335507 )
2016
35
INDUCTION OF MACULAR DETACHMENT FOR THE TREATMENT OF PERSISTENT OR RECURRENT IDIOPATHIC MACULAR HOLES. ( 26866526 )
2016
36
Spectral versus time-domain OCT in detecting preoperative epiretinal membranes that accompany macular holes. ( 27646327 )
2016
37
Optimal management of idiopathic macular holes. ( 26834454 )
2016
38
CLOSING MACULAR HOLES WITH "MACULAR PLUG" WITHOUT GAS TAMPONADE AND POSTOPERATIVE POSTURING. ( 27491044 )
2016
39
Postoperative eccentric macular holes after vitrectomy and internal limiting membrane peeling. ( 27531517 )
2016
40
Inverted Internal Limiting Membrane Insertion for Macular Hole-Associated Retinal Detachment in High Myopia. ( 27156648 )
2016
41
Long-term Follow-up and Outcomes in Traumatic Macular Holes. ( 27084591 )
2016
42
Rhegmatogenous retinal detachment due to a macular hole in a patient with pars planitis: a case report. ( 25565856 )
2015
43
Epiretinal proliferation in lamellar macular holes and full-thickness macular holes: clinical and surgical findings. ( 26311257 )
2015
44
Enhanced vitreous imaging optical coherence tomography in primary macular holes. ( 26349565 )
2015
45
Primary silicone oil tamponade and internal limiting membrane peeling for retinal detachment due to macular hole in highly myopic eyes with chorioretinal atrophy. ( 26560878 )
2015
46
A Comparative Study between Vitrectomy with Internal Tamponade and a New Modified Fiber Optic Illuminated Ando Plombe for Cases of Macular Hole Retinal Detachment in Myopic Eyes. ( 26550487 )
2015
47
Comparing functional and morphologic characteristics of lamellar macular holes with and without lamellar hole-associated epiretinal proliferation. ( 25521439 )
2015
48
Movement of the inner retina complex during the development of primary full-thickness macular holes: implications for hypotheses of pathogenesis. ( 25673252 )
2015
49
Enhanced S-Cone Syndrome and Macular Hole. ( 26067693 )
2015
50
Is visual acuity non-inferior in full-thickness macular holes treated with ocriplasmin? ( 26408507 )
2015

Variations for Macular Holes

Expression for Macular Holes

Search GEO for disease gene expression data for Macular Holes.

Pathways for Macular Holes

Pathways related to Macular Holes according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.33 CCL2 TGFB2 VEGFA
2 11.09 CCL2 TGFB2 VEGFA
3 10.89 ANGPT2 VEGFA
4 10.74 ANGPT2 CCL2 TGFB2
5 10.54 CCL2 VEGFA

GO Terms for Macular Holes

Cellular components related to Macular Holes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 ADM ANGPT2 CCL2 MIF PTGDS RS1
2 extracellular space GO:0005615 9.28 ADM ANGPT2 CCL2 MIF PTGDS RS1

Biological processes related to Macular Holes according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.7 ADM CCL2 SERPINF1
2 negative regulation of gene expression GO:0010629 9.69 MIF SERPINF1 TGFB2
3 positive regulation of angiogenesis GO:0045766 9.63 ADM ANGPT2 VEGFA
4 kidney development GO:0001822 9.58 SERPINF1 TGFB2 VEGFA
5 positive chemotaxis GO:0050918 9.55 MIF VEGFA
6 cellular response to dexamethasone stimulus GO:0071549 9.54 CCL2 SERPINF1
7 response to wounding GO:0009611 9.5 ADM CCL2 TGFB2
8 maternal process involved in female pregnancy GO:0060135 9.49 ANGPT2 CCL2
9 prostaglandin biosynthetic process GO:0001516 9.48 MIF PTGDS
10 angiogenesis GO:0001525 9.46 ANGPT2 CCL2 TGFB2 VEGFA
11 positive regulation of leukocyte migration GO:0002687 9.43 CCL2 VEGFA
12 negative regulation of angiogenesis GO:0016525 9.43 ANGPT2 CCL2 SERPINF1
13 glial cell migration GO:0008347 9.37 CCL2 TGFB2
14 animal organ regeneration GO:0031100 9.13 ADM ANGPT2 CCL2
15 response to hypoxia GO:0001666 9.1 ADM ANGPT2 CCL2 KCNMA1 TGFB2 VEGFA

Molecular functions related to Macular Holes according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 CCL2 MIF TGFB2 VEGFA
2 chemoattractant activity GO:0042056 9.16 MIF VEGFA
3 receptor binding GO:0005102 9.02 ADM ANGPT2 CCL2 MIF TGFB2

Sources for Macular Holes

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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