Aliases & Classifications for Macular Holes

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH
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Macular Holes, Aliases & Descriptions:

Name: Macular Holes 9 11 43 60
 
Macular Hole 9


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Disease Ontology9 DOID:7633
NCIt38 C34795
MeSH33 D012167

Summaries for Macular Holes

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Wikipedia:63 A macular hole is a small break in the macula, located in the center of the eye\'s light-sensitive... more...

MalaCards based summary: Macular Holes, also known as macular hole, is related to vitreous detachment and cataract. An important gene associated with Macular Holes is TGFB2 (transforming growth factor, beta 2), and among its related pathways are PEDF Induced Signaling and Spinal Cord Injury. The compounds trifluorothymidine and n-ethyl-n-nitrosourea have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and cortex, and related mouse phenotypes are integument and hearing/vestibular/ear.

Related Diseases for Macular Holes

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Diseases related to Macular Holes via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1vitreous detachment31.8LHFPL5
2cataract31.5TGFB2, SERPINF1
3central retinal vein occlusion31.1PLAT
4retinal detachment31.1SERPINF1, PLAT, GFAP, HPRT1, TGFB2
5melanoma30.0HPRT1, ANGPT2, VIM, SERPINF1, TGFB2
6retinitis11.2
7retinoschisis10.8
8myopia10.7
9retinal vein occlusion10.6
10choroiditis10.6
11vitreoretinopathy, neovascular inflammatory10.5TGFB2
12alport syndrome10.5
13coats disease10.5
14hemangiopericytoma10.4VIM
15mixed glioma10.4GFAP
16neurilemmoma10.4GFAP
17scotoma10.4
18syringoma10.4GFAP
19choroid plexus papilloma10.4GFAP
20subependymal giant cell astrocytoma10.3GFAP
21giant cell glioblastoma10.3GFAP
22glaucoma 1, open angle, e10.3TGFB2, ABCA4
23choroideremia10.3
24retinitis pigmentosa10.3
25neuroretinitis10.3
26vitelliform macular dystrophy10.3
27eye disease10.3
28neuropathy10.3
29myotonic dystrophy10.3
30x-linked juvenile retinoschisis10.3
31juvenile retinoschisis10.3
32schisis association10.3
33shaken baby syndrome10.3
34coronary thrombosis10.3PLAT
35pneumonia10.2PTGDS, ADM, TGFB2
36malaria10.2HPRT1, MIF
37infertility10.2MIF, TGFB2, PTGDS
38angiosarcoma10.2ANGPT2, VIM
39primary hyperoxaluria10.2ADM, HPRT1, PTGDS
40microvascular complications of diabetes 310.2MIF, SERPINF1, ADM
41spiradenoma10.2TGFB2, ABCA4, SERPINF1
42macular degeneration, age-related, 110.2PLAT
43microvascular complications of diabetes 510.2TGFB2, ANGPT2, ADM, SERPINF1
44rhabdoid meningioma10.2VIM, GFAP
45astroblastoma10.2GFAP, VIM
46myoepithelioma10.1VIM, GFAP
47stargardt disease10.1
48posterior uveal melanoma10.1
49diabetic macular edema10.1
50hypertensive retinopathy10.1

Graphical network of the top 20 diseases related to Macular Holes:



Diseases related to macular holes

Symptoms for Macular Holes

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Drugs & Therapeutics for Macular Holes

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Drug clinical trials:

Search ClinicalTrials for Macular Holes

Search NIH Clinical Center for Macular Holes

Genetic Tests for Macular Holes

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Anatomical Context for Macular Holes

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MalaCards organs/tissues related to Macular Holes:

31
Eye, Retina, Cortex, Testes

Animal Models for Macular Holes or affiliated genes

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Publications for Macular Holes

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Articles related to Macular Holes:

(show top 50)    (show all 575)
idTitleAuthorsYear
1
Inverted ILM peeling for idiopathic and other etiology macular holes. (25230973)
2014
2
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
3
Management of rhegmatogenous retinal detachment with coexisting macular hole: a comparison of vitrectomy with and without internal limiting membrane peeling. (23222496)
2013
4
Co-existent choroidal neovascular membrane and macular hole in pathologic myopia: a long follow-up clinical outcome and literature review. (24392342)
2013
5
Foveal thickness in healthy fellow eyes of patients with unilateral macular holes. (23540711)
2013
6
23- vs 20-gauge pars plana vitrectomy in combination with bimanual microincisional cataract surgery (b-MICS) for the treatment of macular hole and cataract as a one-step procedure. (23743530)
2013
7
Risk assessment of idiopathic macular holes undergoing vitrectomy with dye-assisted internal limiting membrane peeling. (23514792)
2013
8
Surgery for macular holes associated with unusual concomitant pathologies. (24082671)
2013
9
Analysis of Retinal Ganglion Cell Complex Thickness after Brilliant Blue-Assisted Vitrectomy for Idiopathic Macular Holes. (24143870)
2013
10
Episcleral macular buckling for posterior retinal detachment in silicone oil filled eyes associated with myopic macular hole. (23638417)
2013
11
INVERTED INTERNAL LIMITING MEMBRANE FLAP TECHNIQUE FOR SURGICAL REPAIR OF MYOPIC MACULAR HOLES. (24263468)
2013
12
Spontaneous macular hole closure without posterior vitreous detachment in a patient previously treated for diabetic maculopathy. (22973980)
2013
13
Traction-induced foveal damage predisposes eyes with pre-existing posterior vitreous detachment to idiopathic macular hole formation. (22388594)
2012
14
Retinoschisis: a predictive factor in vitrectomy for macular holes without retinal detachment in highly myopic eyes. (21586755)
2012
15
SD-OCT imaging of idiopathic macular holes with spontaneous closure. (22356437)
2012
16
Full-thickness macular hole formation associated with central serous chorioretinopathy. (22729443)
2012
17
The dynamic healing process of idiopathic macular holes after surgical repair: a spectral-domain optical coherence tomography study. (21345999)
2011
18
1000 cSt silicone oil vs heavy silicone oil as intraocular tamponade in retinal detachment associated to myopic macular hole. (21080197)
2011
19
Non-Foveal Macular Holes After PPV for Macular Pucker. (20844682)
2010
20
Traumatic macular holes secondary to combat ocular trauma. (18997638)
2009
21
Extended internal limiting membrane peeling in the management of unusually large macular holes. (19320310)
2009
22
Parafoveal telangiectasia (PFT) has been associated with changes in macular architecture and macular holes (lamellar and full thickness). (18185162)
2008
23
Outcomes of 23- and 25-gauge transconjunctival sutureless vitrectomies for idiopathic macular holes. (18614566)
2008
24
Treatment of stage 2 macular hole by intravitreous injection of expansile gas and induction of posterior vitreous detachment. (17070585)
2007
25
Successful treatment of macular holes associated with peripheral retinal vascular tumours. (16710432)
2007
26
Stage 0 macular holes. (16061097)
2005
27
Foveal schisis as a cause of retinal detachment secondary to macular hole in juvenile X-linked retinoschisis. (15805920)
2005
28
Assessing responses of the macula in patients with macular holes using a new system measuring localized visual acuity and the mfERG. (16328926)
2005
29
Retinal telangiectasia in association with macular hole formation. (14716321)
2004
30
Macular holes: classification, epidemiology, natural history and treatment. (12485276)
2002
31
Bilateral macular holes: an unusual feature of alport syndrome. (12172121)
2002
32
Clinical pathogenesis of macular holes in patients affected by retinitis pigmentosa. (12708609)
2002
33
Surgery for full-thickness macular holes. (11733243)
2001
34
The visual performance and metamorphopsia of patients with macular holes. (10636412)
2000
35
Visual and anatomical results of surgery for long standing macular holes. (10655189)
2000
36
A new approach to stage 3 macular holes. (10919918)
2000
37
Time course of the size of the dark area in macular holes by scanning laser ophthalmoscopy. (10770618)
2000
38
Prevalence, correlates, and natural history of epiretinal membranes surrounding idiopathic macular holes. Virectomy for Macular Hole Study Group. (10811074)
2000
39
Morphological evaluation of full-thickness idiopathic macular holes by optical coherence tomography. (10544977)
1999
40
Anomaloscope examination in macular gliosis, macular holes and central serous choroidopathy. (9602315)
1998
41
Macular holes and PVD. (8600404)
1996
42
Autologous platelet concentrate for the treatment of full-thickness macular holes. (8543204)
1995
43
Full-thickness macular holes treated with vitrectomy and tissue glue. (7642336)
1994-1995
44
A prospective natural history study and kinetic ultrasound evaluation of idiopathic macular holes. (8302564)
1994
45
Results of surgical treatment of recent-onset full-thickness idiopathic macular holes. (7993209)
1994
46
Risk of decreased visual acuity in full-thickness idiopathic macular holes. (8250073)
1993
47
Transforming growth factor-beta 2 for the treatment of full-thickness macular holes. A prospective randomized study. (1495798)
1992
48
Causative factors of retinal detachment in macular holes. (1961986)
1991
49
Treatment of retinal detachment due to macular holes without chorio-retinal lesions. A seven-year follow-up study. (6963057)
1982
50
Macular holes associated with proliferative sickle cell retinopathy. (687199)
1978

Variations for Macular Holes

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Expression for genes affiliated with Macular Holes

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Search GEO for disease gene expression data for Macular Holes.

Pathways for genes affiliated with Macular Holes

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Compounds for genes affiliated with Macular Holes

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Compounds related to Macular Holes according to GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1trifluorothymidine43 5911.2HPRT1, PTGDS
2n-ethyl-n-nitrosourea439.8GFAP, HPRT1
3beraprost sodium439.6ADM, PLAT
4eosin439.6VIM, GFAP
5prostaglandin439.5ADM, VIM, TGFB2, PTGDS
6hydrocortisone43 2 59 1212.4MIF, ADM, VIM, TGFB2
7omapatrilat439.4PLAT, ADM
8catecholamine439.4VIM, ADM, MIF
9corticosterone43 59 2411.4MIF, ADM, GFAP
10s 100439.3VIM, GFAP
11glyceraldehyde 3-phosphate439.3HPRT1, ANGPT2, ADM, GFAP
12dbc-amp439.3ADM, VIM, GFAP
13neomycin439.3GFAP, VIM, HPRT1
14nitric oxide43 24 1211.2TGFB2, SERPINF1, ADM, ANGPT2, MIF
15potassium43 24 1211.2GFAP, TGFB2, SERPINF1, ADM
16guanylate439.2SERPINF1, VIM, ADM, ANGPT2, HPRT1
17streptozotocin439.1GFAP, SERPINF1, VIM, ADM
18spec-t439.1GFAP, ADM, PLAT
19p003439.0TGFB2, ADM, PLAT
20vitamin a43 24 1211.0ABCA4, PTGDS, TGFB2, VIM, HPRT1
21methionine439.0MIF, VIM, SERPINF1, GFAP
22forskolin43 49 1211.0GFAP, TGFB2, VIM, ADM
23indomethacin43 28 59 1211.9TGFB2, VIM, ADM, PLAT
24silicone438.9PLAT, VIM, GFAP
25genistein43 28 59 2 24 1213.9MIF, VIM, TGFB2, GFAP
26histamine43 28 2410.8PLAT, ADM, VIM, PTGDS
27morphine43 49 28 1211.8HPRT1, MIF, GFAP
28cyclosporin a43 28 5910.8PLAT, ANGPT2, ADM, TGFB2
29h2o2438.8SERPINF1, VIM, ADM, ANGPT2, MIF, HPRT1
30thymidine43 249.7GFAP, TGFB2, ADM, ANGPT2, MIF, HPRT1
31tamoxifen43 49 28 1211.6TGFB2, VIM, ADM, HPRT1, PLAT
32isoproterenol43 129.6GFAP, VIM, ADM, PLAT
33testosterone43 59 24 1211.6GFAP, PTGDS, TGFB2, VIM, ADM, HPRT1
34progesterone43 28 59 24 1212.3GFAP, TGFB2, VIM, ADM, PLAT
35estradiol43 24 1210.3GFAP, TGFB2, VIM, MIF, PLAT
36cholesterol43 28 24 1211.3ABCA4, GFAP, PTGDS, ADM, PLAT
37estrogen438.3GFAP, PTGDS, TGFB2, VIM, ADM, ANGPT2
38vegf438.2GFAP, TGFB2, SERPINF1, VIM, ADM, ANGPT2
39adenylate438.2GFAP, VIM, ADM, HPRT1, PLAT
40lipid438.2ABCA4, GFAP, PTGDS, VIM, ADM, MIF
41cycloheximide438.1GFAP, PTGDS, TGFB2, VIM, ADM, PLAT
42glutamate438.0GFAP, TGFB2, SERPINF1, VIM, HPRT1, PLAT
43glucose437.9GFAP, TGFB2, SERPINF1, ADM, ANGPT2, MIF
44dexamethasone43 49 28 1210.9GFAP, TGFB2, SERPINF1, VIM, ADM, ANGPT2
45matrigel437.8GFAP, TGFB2, SERPINF1, VIM, ADM, ANGPT2
46paraffin437.8GFAP, TGFB2, VIM, ADM, ANGPT2, MIF
47serine437.4GFAP, TGFB2, SERPINF1, VIM, ANGPT2, MIF
48retinoic acid43 248.2GFAP, PTGDS, TGFB2, SERPINF1, VIM, ADM
49creatinine437.1PLAT, GFAP, PTGDS, TGFB2, VIM, ADM
50cysteine437.1GFAP, TGFB2, SERPINF1, VIM, ADM, ANGPT2

GO Terms for genes affiliated with Macular Holes

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Cellular components related to Macular Holes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310128.8TGFB2, SERPINF1, PLAT
2extracellular vesicular exosomeGO:00700628.1PLAT, HPRT1, MIF, VIM, SERPINF1
3extracellular spaceGO:00056157.9PLAT, PTGDS, TGFB2, SERPINF1, ADM, ANGPT2
4extracellular regionGO:00055767.8PTGDS, TGFB2, SERPINF1, ADM, ANGPT2, MIF

Biological processes related to Macular Holes according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1neuron projection regenerationGO:00311029.6ADM, GFAP
2prostaglandin biosynthetic processGO:00015169.5MIF, PTGDS
3Bergmann glial cell differentiationGO:00600209.5VIM, GFAP
4response to woundingGO:00096119.4GFAP, TGFB2, ADM
5astrocyte developmentGO:00140029.3VIM, GFAP
6negative regulation of neuron projection developmentGO:00109779.3VIM, GFAP
7intermediate filament organizationGO:00451099.2GFAP, VIM
8response to hypoxiaGO:00016669.0TGFB2, ADM, ANGPT2, PLAT
9response to glucocorticoidGO:00513849.0PLAT, ADM, SERPINF1, PTGDS

Molecular functions related to Macular Holes according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:00051029.3MIF, ANGPT2, ADM, TGFB2

Products for genes affiliated with Macular Holes

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Sources for Macular Holes

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet