MCID: MJR001
MIFTS: 58

Major Depressive Disorder malady

Summaries for Major Depressive Disorder

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

MalaCards: Major Depressive Disorder, also known as single major depressive episode, is related to bipolar disorder and anxiety disorder. An important gene associated with Major Depressive Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are SIDS Susceptibility Pathways and Circadian entrainment. The compounds paroxetine and citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes.

Wikipedia:63 Major depressive disorder (MDD) (also known as clinical depression, major depression, unipolar... more...

Aliases & Classifications for Major Depressive Disorder

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Sources:
8Disease Ontology, 9diseasecard, 22GTR, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

major depressive disorder 8 9 22 10 60
single major depressive episode 8 60
recurrent major depressive episodes 60
recurrent major depression 8


Related Diseases for Major Depressive Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Major Depressive Disorder family:

Major Depressive Disorder 1 Major Depressive Disorder 2

Diseases related to Major Depressive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.3SLC6A4, HTR2A
2anxiety disorder31.2HTR1A, HTR2A, TPH1, SLC6A4, MAOA
3schizophrenia31.1SLC6A4, MAOA, HTR1A, HTR2A, TPH1
4panic disorder31.1SLC6A4, HTR1A
5generalized anxiety disorder31.1HTR1A, SLC6A4
6personality disorder31.0SLC6A4, TPH1, MAOA
7mood disorder31.0TPH1, SLC6A4, HTR1A, MAOA, HTR2A
8dysthymic disorder30.8HTR2A, MAOA
9psychotic disorder30.7HTR1A, HTR2A, MAOA, TPH1, SLC6A4
10borderline personality disorder30.7SLC6A4, MAOA, TPH1
11melancholia30.5MAOA
12obsessive-compulsive disorder30.5HTR2A, HTR1A, MAOA, SLC6A4, TPH1
13attention deficit hyperactivity disorder30.4MAOA, SLC6A4, HTR2A
14alcohol dependence30.4MAOA, HTR2A, SLC6A4
15eating disorder30.4HTR1A, HTR2A, SLC6A4
16dementia30.4MAOA, HTR2A, HTR1A
17endogenous depression30.4MAOA
18chronic fatigue syndrome30.3MAOA, HTR1A, SLC6A4
19major depressive disorder and accelerated response to antidepressant drug treatment30.3BP51, FKBP5
20conduct disorder30.2SLC6A4, MAOA
21parkinson's disease30.2HTR1A, MAOA
22nicotine dependence30.2SLC6A4
23schizoaffective disorder30.1SLC6A4, HTR2A
24anorexia nervosa30.0TPH1, SLC6A4, MAOA, HTR2A, HTR1A
25seasonal affective disorder30.0HTR1A, TPH1, SLC6A4, HTR2A
26gilles de la tourette syndrome30.0SLC6A4, MAOA, HTR1A, HTR2A
27substance dependence30.0SLC6A4, TPH1
28agoraphobia30.0HTR1A, MAOA
29pain disorder10.6
30sleep disorder10.6
31atypical depressive disorder10.5
32bipolar i disorder10.5
33sexual disorder10.5
34somatization disorder10.4
35neuronitis10.4
36mental depression10.4
37postpartum depression10.3
38alexithymia10.3
39cerebritis10.3
40adjustment disorder10.3
41alzheimer's disease10.3
42post-traumatic stress disorder10.3
43brain disease10.3
44diabetes mellitus10.3
45obesity10.3
46physical disorder10.3
47major depressive disorder 110.3
48major depressive disorder 210.3
49cocaine dependence10.2
50rumination disorder10.2

Graphical network of the top 20 diseases related to Major Depressive Disorder:



Diseases related to major depressive disorder

Clinical Features for Major Depressive Disorder

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Drugs & Therapeutics for Major Depressive Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Major Depressive Disorder

Drug clinical trials:

Search ClinicalTrials for Major Depressive Disorder

Search NIH Clinical Center for Major Depressive Disorder

Search CenterWatch for Major Depressive Disorder

Genetic Tests for Major Depressive Disorder

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22GTR
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Genetic tests related to Major Depressive Disorder:

id Genetic test Affiliating Genes
1 Major Depressive Disorder22

Anatomical Context for Major Depressive Disorder

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32MalaCards
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MalaCards organs/tissues related to Major Depressive Disorder:

32
Brain, Cortex, Testes, Prefrontal cortex, Amygdala, Bone, Pituitary, Cingulate cortex, Endothelial, Monocytes, Heart, Thyroid, Ovary, Spinal cord, Temporal lobe, T cells, Breast, Thalamus, Cerebellum

Animal Models for Major Depressive Disorder or affiliated genes

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Publications for Major Depressive Disorder

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Sources:
50PubMed
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Articles related to Major Depressive Disorder:

(show top 50)    (show all 1061)
idTitleAuthorsYear
1
Sexual Dysfunction associated with Second-Generation Antidepressants in Patients with Major Depressive Disorder: Results from a Systematic Review with Network Meta-Analysis. (24338044)
2014
2
Pericardial, intra-abdominal, and subcutaneous adipose tissue in patients with major depressive disorder. (24433292)
2014
3
The efficacy of extended-release levomilnacipran in moderate to severe major depressive disorder: secondary and post-hoc analyses from a randomized, double-blind, placebo-controlled study. (24172160)
2014
4
Distinguishing bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. (24107761)
2013
5
Differential impact of isolated psychotic symptoms on treatment outcome of major depressive disorder in the STAR*D cohort of Whites, Blacks and Latinos. (23489398)
2013
6
Low-dose mirtazapine added to selective serotonin reuptake inhibitors in pregnant women with major depression or panic disorder including symptoms of severe nausea, insomnia and decreased appetite: three cases. (23363390)
2013
7
Fatigue and occupational functioning in major depressive disorder. (23652385)
2013
8
White matter abnormalities in adolescents with major depressive disorder. (24242685)
2013
9
Influence of sex and menopausal status on response, remission, and recurrence in patients with recurrent major depressive disorder treated with venlafaxine extended release or fluoxetine: analysis of data from the PREVENT study. (24345717)
2013
10
Prospective study of substance-induced and independent major depressive disorder among individuals with substance use disorders in a nationally representative sample. (23649540)
2013
11
Challenges in the treatment of major depressive disorder with psychotic features. (23599251)
2013
12
Selegiline remarkably improved stage 5 treatment-resistant major depressive disorder: a case report. (24204150)
2013
13
Polyunsaturated fatty acid associations with dopaminergic indices in major depressive disorder. (24300434)
2013
14
Atypical depressive symptoms and obesity in a national sample of older adults with major depressive disorder. (23554014)
2013
15
Predictors of depressive symptoms at hospital discharge in patients with major depressive disorder. (23428235)
2013
16
Functional impairment in patients with major depressive disorder and comorbid anxiety disorder. (24331287)
2013
17
Does screening HIV-positive individuals in uganda for major depressive disorder improve case detection rates and antidepressant prescription? (23247361)
2013
18
A clinical risk stratification tool for predicting treatment resistance in major depressive disorder. (23380715)
2013
19
A prospective study of diagnostic conversion of major depressive disorder to bipolar disorder in pregnancy and postpartum. (24127853)
2013
20
Newly diagnosed major depressive disorder and the risk of erectile dysfunction: a population-based cohort study in Taiwan. (23850431)
2013
21
Case Report of a 24-Year-Old Man With Resolution of Treatment-Resistant Major Depressive Disorder and Comorbid PTSD Using rTMS. (24080541)
2013
22
Resequencing three candidate genes for major depressive disorder in a dutch cohort. (24278217)
2013
23
Heart rate variability is a trait marker of major depressive disorder: evidence from the sertraline vs. electric current therapy to treat depression clinical study. (23759172)
2013
24
Temporal discounting in major depressive disorder. (24176142)
2013
25
Comparison of escitalopram and paroxetine in the treatment of major depressive disorder. (23881184)
2013
26
Relation between structural and functional connectivity in major depressive disorder. (23399372)
2013
27
Structural changes in hippocampal subfields in major depressive disorder: a high-field magnetic resonance imaging study. (23419546)
2013
28
Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorder. (22609366)
2012
29
Residual memory dysfunction in recurrent major depressive disorder--a longitudinal study from Juntendo University Mood Disorder Project. (22832170)
2012
30
Sustained unemployment in psychiatric outpatients with bipolar depression compared to major depressive disorder with comorbid borderline personality disorder. (23057759)
2012
31
Genotype distributions and allele frequencies of possible major depressive disorder-associated single nucleotide polymorphisms, cyclic adenosine monophosphate response element binding protein 1 rs4675690 and Piccolo rs2522833, in a Japanese population. (22293360)
2012
32
Cortico-cortical white matter motor pathway microstructure is related to psychomotor retardation in major depressive disorder. (23284950)
2012
33
CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population. (21040781)
2011
34
Cost of post-traumatic stress disorder vs major depressive disorder among patients covered by medicaid or private insurance. (21851139)
2011
35
Antidepressants for major depressive disorder and dysthymic disorder in patients with comorbid alcohol use disorders: a meta-analysis of placebo-controlled randomized trials. (21536001)
2011
36
A polymorphism in the microRNA-30e precursor associated with major depressive disorder risk and P300 waveform. (20579744)
2010
37
Plasma levels of brain-derived neurotrophic factor and interleukin-6 in patients with dysthymic disorder: comparison with age- and sex-matched major depressed patients and healthy controls. (21312291)
2010
38
Is alexithymia a risk factor for major depression, personality disorder, or alcohol use disorders? A prospective population-based study. (20159212)
2010
39
ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. (17913323)
2008
40
Association study of paroxetine therapeutic response with SERT gene polymorphisms in patients with major depressive disorder. (17853254)
2008
41
The structure of distress following trauma: posttraumatic stress disorder, major depressive disorder, and generalized anxiety disorder. (18729617)
2008
42
Genetic pathway of major depressive disorder in shortening telomeric length. (17417064)
2007
43
Family history of mood disorder and characteristics of major depressive disorder: a STAR*D (sequenced treatment alternatives to relieve depression) study. (16690084)
2007
44
Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndrome. (16500943)
2006
45
The Gem interacting protein (GMIP) gene is associated with major depressive disorder. (16086184)
2005
46
Positive association between T-182C polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a japanese population. (15539861)
2004
47
An efficacy/effectiveness study of cognitive-behavioral treatment for adolescents with comorbid major depression and conduct disorder. (15167082)
2004
48
Social characteristics of seasonal affective disorder patients: comparison with suicide attempters with non-seasonal major depression and other mood disorder patients. (12648896)
2003
49
Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression. (11126396)
2000
50
Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers. (8131152)
1993

Genetic Variations for Major Depressive Disorder

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Expression for genes affiliated with Major Depressive Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Major Depressive Disorder

Search GEO for disease gene expression data for Major Depressive Disorder.

Pathways for genes affiliated with Major Depressive Disorder

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Sources:
37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Major Depressive Disorder

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Major Depressive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1paroxetine44 49 28 1114.5HTR2A, SLC6A4, HTR1A, TPH1, MAOA, FKBP5
2citalopram49 44 11 2414.5TPH1, SLC6A4, HTR2A, FKBP5, MAOA, HTR1A
3maoa4411.4TPH1, SLC6A4, HTR2A, HTR1A, MAOA
4fluvoxamine44 49 1113.4MAOA, HTR1A, HTR2A, TPH1, SLC6A4
5clomipramine44 49 1113.4MAOA, SLC6A4, HTR2A, FKBP5, HTR1A
6fluoxetine49 44 28 1114.4HTR2A, TPH1, SLC6A4, MAOA, HTR1A
75-hydroxytryptamine4411.3SLC6A4, HTR1A, HTR2A, MAOA, TPH1
8mdma4411.3TPH1, SLC6A4, HTR1A, MAOA
9escitalopram44 49 11 2414.3FKBP5, HTR2A, SLC6A4, HTR1A
10antidepressants4911.3HTR1A, HTR2A, FKBP5, TPH1
115-hydroxytryptophan4411.3TPH1, HTR1A, HTR2A, SLC6A4
12nefazodone44 49 1113.3HTR1A, HTR2A, FKBP5, SLC6A4
13mianserin28 44 1113.3HTR2A, SLC6A4, HTR1A, MAOA
14fenfluramine28 44 1113.3HTR1A, SLC6A4, HTR2A, TPH1
15venlafaxine49 44 11 2414.3HTR1A, FKBP5, SLC6A4, HTR2A
16amitriptyline44 49 28 1114.3HTR1A, HTR2A, MAOA, SLC6A4
17desipramine44 49 1113.2HTR2A, HTR1A, MAOA, SLC6A4
18imipramine44 49 28 11 2415.2HTR1A, HTR2A, MAOA, SLC6A4
19p-chlorophenylalanine4411.2SLC6A4, HTR1A, TPH1
208-hydroxy-2-(di-n-propylamino)tetralin4411.2SLC6A4, HTR1A, HTR2A
21bufotenine28 44 1113.2MAOA, HTR1A, HTR2A
22p-chloroamphetamine4411.2SLC6A4, MAOA, HTR1A
23carbon-114411.2HTR1A, MAOA, SLC6A4
24norepinephrine44 11 2413.2HTR2A, MAOA, HTR1A, SLC6A4, TPH1
25m-chlorophenylpiperazine4411.2HTR1A, SLC6A4, HTR2A
26naratriptan44 28 1113.2MAOA, HTR2A, HTR1A
27MMDA1111.2MAOA, HTR2A, SLC6A4
28mcpp4411.1SLC6A4, HTR1A, HTR2A
29minaprine44 1112.1MAOA, HTR2A, SLC6A4
30pindolol44 28 1113.1HTR1A, HTR2A, SLC6A4
31trazodone44 28 1113.1HTR1A, HTR2A, SLC6A4
32trimipramine49 44 1113.1HTR2A, HTR1A, SLC6A4
33methysergide44 28 1113.1HTR1A, HTR2A, MAOA
34sertraline44 28 49 11 2415.1HTR1A, SLC6A4, MAOA
35homovanillic acid44 2412.1TPH1, SLC6A4, MAOA
36ketanserin28 4412.1HTR2A, HTR1A, SLC6A4
375-hydroxyindoleacetic acid44 2412.1TPH1, SLC6A4, MAOA
38doxepin44 28 49 1114.1HTR2A, SLC6A4, HTR1A
39nortriptyline44 49 28 1114.0HTR1A, HTR2A, SLC6A4
40sumatriptan44 28 59 49 11 2416.0HTR2A, MAOA, HTR1A
415,7-dihydroxytryptamine4410.9HTR2A, SLC6A4
42phenylpiperazine4410.9HTR1A, HTR2A
43phenylbiguanide4410.9HTR1A, HTR2A
44Cinitapride1110.8HTR2A, HTR1A
45alpha-methylserotonin4410.8HTR1A, HTR2A
46urapidil4410.7HTR2A, HTR1A
47ergoline4410.7HTR2A, HTR1A
48amperozide4410.7HTR1A, HTR2A
49perospirone4410.6HTR2A, HTR1A
50lysergic acid diethylamide4410.4HTR2A, HTR1A

GO Terms for genes affiliated with Major Depressive Disorder

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16Gene Ontology
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Biological processes related to Major Depressive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.7HTR2A, HTR1A
2vasoconstrictionGO:04231010.7SLC6A4, HTR1A
3serotonin receptor signaling pathwayGO:00721010.6HTR2A, HTR1A
4regulation of behaviorGO:05079510.4HTR2A, HTR1A

Products for genes affiliated with Major Depressive Disorder

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  • Antibodies
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Sources for Major Depressive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet