MCID: MJR001
MIFTS: 58

Major Depressive Disorder malady

Summaries for Major Depressive Disorder

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

MalaCards: Major Depressive Disorder, also known as single major depressive episode, is related to bipolar disorder and anxiety disorder. An important gene associated with Major Depressive Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are SIDS Susceptibility Pathways and Circadian entrainment. The compounds paroxetine and citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes.

Wikipedia:63 Major depressive disorder (MDD) (also known as clinical depression, major depression, unipolar... more...

Aliases & Classifications for Major Depressive Disorder

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Sources:
8Disease Ontology, 9diseasecard, 22GTR, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

major depressive disorder 8 9 22 10 60
single major depressive episode 8 60
recurrent major depressive episodes 60
recurrent major depression 8


Related Diseases for Major Depressive Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Major Depressive Disorder family:

Major Depressive Disorder 1 Major Depressive Disorder 2

Diseases related to Major Depressive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.3SLC6A4, HTR2A
2anxiety disorder31.2HTR1A, HTR2A, TPH1, SLC6A4, MAOA
3schizophrenia31.1SLC6A4, MAOA, HTR1A, HTR2A, TPH1
4panic disorder31.1SLC6A4, HTR1A
5generalized anxiety disorder31.1HTR1A, SLC6A4
6personality disorder31.0SLC6A4, TPH1, MAOA
7mood disorder31.0TPH1, SLC6A4, HTR1A, MAOA, HTR2A
8dysthymic disorder30.8HTR2A, MAOA
9psychotic disorder30.7HTR1A, HTR2A, MAOA, TPH1, SLC6A4
10borderline personality disorder30.7SLC6A4, MAOA, TPH1
11melancholia30.5MAOA
12obsessive-compulsive disorder30.5HTR2A, HTR1A, MAOA, SLC6A4, TPH1
13attention deficit hyperactivity disorder30.4MAOA, SLC6A4, HTR2A
14alcohol dependence30.4MAOA, HTR2A, SLC6A4
15eating disorder30.4HTR1A, HTR2A, SLC6A4
16dementia30.4MAOA, HTR2A, HTR1A
17endogenous depression30.4MAOA
18chronic fatigue syndrome30.3MAOA, HTR1A, SLC6A4
19major depressive disorder and accelerated response to antidepressant drug treatment30.3BP51, FKBP5
20conduct disorder30.2SLC6A4, MAOA
21parkinson's disease30.2HTR1A, MAOA
22nicotine dependence30.2SLC6A4
23schizoaffective disorder30.1SLC6A4, HTR2A
24anorexia nervosa30.0TPH1, SLC6A4, MAOA, HTR2A, HTR1A
25seasonal affective disorder30.0HTR1A, TPH1, SLC6A4, HTR2A
26gilles de la tourette syndrome30.0SLC6A4, MAOA, HTR1A, HTR2A
27substance dependence30.0SLC6A4, TPH1
28agoraphobia30.0HTR1A, MAOA
29pain disorder10.6
30sleep disorder10.6
31atypical depressive disorder10.5
32bipolar i disorder10.5
33sexual disorder10.5
34somatization disorder10.4
35neuronitis10.4
36mental depression10.4
37postpartum depression10.3
38alexithymia10.3
39cerebritis10.3
40adjustment disorder10.3
41alzheimer's disease10.3
42post-traumatic stress disorder10.3
43brain disease10.3
44diabetes mellitus10.3
45obesity10.3
46physical disorder10.3
47major depressive disorder 110.3
48major depressive disorder 210.3
49cocaine dependence10.2
50rumination disorder10.2

Graphical network of the top 20 diseases related to Major Depressive Disorder:



Diseases related to major depressive disorder

Clinical Features for Major Depressive Disorder

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Drugs & Therapeutics for Major Depressive Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Major Depressive Disorder

Drug clinical trials:

Search ClinicalTrials for Major Depressive Disorder

Search NIH Clinical Center for Major Depressive Disorder

Search CenterWatch for Major Depressive Disorder

Genetic Tests for Major Depressive Disorder

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Sources:
22GTR
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Genetic tests related to Major Depressive Disorder:

id Genetic test Affiliating Genes
1 Major Depressive Disorder22

Anatomical Context for Major Depressive Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Major Depressive Disorder:

32
Brain, Cortex, Testes, Prefrontal cortex, Amygdala, Bone, Pituitary, Cingulate cortex, Endothelial, Monocytes, Heart, Thyroid, Ovary, Spinal cord, Temporal lobe, T cells, Breast, Thalamus, Cerebellum

Animal Models for Major Depressive Disorder or affiliated genes

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Publications for Major Depressive Disorder

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Sources:
50PubMed
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Articles related to Major Depressive Disorder:

(show top 50)    (show all 1061)
idTitleAuthorsYear
1
A systematic review and meta-analysis of the evidence base for add-on treatment for patients with major depressive disorder who have not responded to antidepressant treatment: A European perspective. (24108407)
2014
2
Vortioxetine for major depressive disorder: a systematic review of the efficacy and safety profile for this newly approved antidepressant - what is the number needed to treat, number needed to harm and likelihood to be helped or harmed? (24165478)
2014
3
Health-related quality of life in recurrent major depressive disorder--a 10-year follow-up study. (23245634)
2013
4
Neurovascular unit dysfunction with blood-brain barrier hyperpermeability contributes to major depressive disorder: a review of clinical and experimental evidence. (24289502)
2013
5
Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study. (23773978)
2013
6
Stigmatizing attitudes differ across mental health disorders: a comparison of stigma across eating disorders, obesity, and major depressive disorder. (23538972)
2013
7
Distinguishing bipolar disorder from major depressive disorder: does an increased risk of substance use account for other differences? (23231373)
2013
8
Aripiprazole augmentation for major depressive disorder: dosing patterns in a naturalistic treatment setting. (24108149)
2013
9
Epidemiological and clinical characterization following a first psychotic episode in major depressive disorder: comparisons with schizophrenia and bipolar I disorder in the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS). (23716714)
2013
10
Efficacy and safety of duloxetine 60 mg once daily in major depressive disorder: a review with expert commentary. (24432034)
2013
11
Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder. (23953680)
2013
12
Efficacy and safety of desvenlafaxine 50 mg/d in a randomized, placebo-controlled study of perimenopausal and postmenopausal women with major depressive disorder. (24229754)
2013
13
How natural is it for nature to help with major depressive disorder? (23574163)
2013
14
Prevalence of current, 12-month and lifetime major depressive disorder among patients with systemic sclerosis. (23256181)
2013
15
Study of effects of selective serotonin reuptake inhibitors on stages of sexual function in Iranian patients with major depressive disorder. (24294483)
2013
16
Remission and functioning in major depressive disorder. (24096391)
2013
17
EEG-based upper-alpha neurofeedback for cognitive enhancement in major depressive disorder: A preliminary, uncontrolled study. (24111179)
2013
18
Plasma Levels of IL-23 and IL-17 before and after Antidepressant Treatment in Patients with Major Depressive Disorder. (24302954)
2013
19
Usefulness of visual evaluation of the anterior thalamic radiation by diffusion tensor tractography for differentiating between Alzheimer's disease and elderly major depressive disorder patients. (23589698)
2013
20
Cognitive symptoms in patients with major depressive disorder and their implications for clinical practice. (24345473)
2013
21
Monoamine oxidases in major depressive disorder and alcoholism. (22890201)
2012
22
Increases in amplitude of low-frequency fluctuations in left fronto-parietal area after duloxetine therapy in first-episode, drug-naA^ve, major depressive disorder with panic disorder patients. (23037667)
2012
23
Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. (22880079)
2012
24
Functional impairment related to painful physical symptoms in patients with generalized anxiety disorder with or without comorbid major depressive disorder: post hoc analysis of a cross-sectional study. (21510887)
2011
25
Poor replication of candidate genes for major depressive disorder using genome-wide association data. (20351714)
2011
26
Duloxetine's modest short-term influences in subcortical structures of first episode drug-naA^ve patients with major depressive disorder and panic disorder. (21820879)
2011
27
Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder. (19900711)
2010
28
Alexithymia and temperament and character model of personality in patients with major depressive disorder. (19932828)
2010
29
The role of the inflammatory markers ferritin, transferrin and fibrinogen in the relationship between major depression and cardiovascular disorders - The German Health Interview and Examination Survey. (20073117)
2010
30
Research letter: Psychotherapy increases brain serotonin 5-HT1A receptors in patients with major depressive disorder. (19903365)
2010
31
Disorder specificity despite comorbidity: resting EEG alpha asymmetry in major depressive disorder and post-traumatic stress disorder. (20708650)
2010
32
Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression. (20080186)
2010
33
A cis-phase interaction study of genetic variants within the MAOA gene in major depressive disorder. (20691428)
2010
34
The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder. (20682308)
2010
35
Association of the adrenergic alpha 2a receptor--1291C/G polymorphism with weight change and treatment response to mirtazapine in patients with major depressive disorder. (19401164)
2009
36
Effect of the 5-HTTLPR polymorphism in the serotonin transporter gene on major depressive disorder and related comorbid disorders. (19125107)
2009
37
Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. (19593178)
2009
38
Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder. (19545858)
2009
39
Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders. (18163385)
2008
40
Comparing postpartum depression and major depressive disorder: issues in assessment. (17654110)
2007
41
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
42
Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. (15583702)
2005
43
Serotonin 5-HT1A, 5-HT1B, and 5-HT2A receptor mRNA expression in subjects with major depression, bipolar disorder, and schizophrenia. (14744462)
2004
44
Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. (12555227)
2003
45
Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response. (12700687)
2003
46
Tumor necrosis factor-beta gene polymorphism may not be associated with major depressive disorder in the Korean population. (12519452)
2003
47
Serotonin transporter polymorphism and response to SSRIs in major depression and relevance to anxiety disorders and substance abuse. (11256582)
2000
48
Intergenerational CAG repeat expansion at ERDA1 in a family with childhood-onset depression, schizoaffective disorder, and recurrent major depression. (10050972)
1999
49
Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder. (9194044)
1997
50
Major depression versus organic mood disorder: a questionable distinction. (2404962)
1990

Genetic Variations for Major Depressive Disorder

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Expression for genes affiliated with Major Depressive Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Major Depressive Disorder

Search GEO for disease gene expression data for Major Depressive Disorder.

Pathways for genes affiliated with Major Depressive Disorder

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Sources:
37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Major Depressive Disorder

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Major Depressive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1paroxetine44 49 28 1114.5HTR2A, SLC6A4, HTR1A, TPH1, MAOA, FKBP5
2citalopram49 44 11 2414.5TPH1, SLC6A4, HTR2A, FKBP5, MAOA, HTR1A
3maoa4411.4TPH1, SLC6A4, HTR2A, HTR1A, MAOA
4fluvoxamine44 49 1113.4MAOA, HTR1A, HTR2A, TPH1, SLC6A4
5clomipramine44 49 1113.4MAOA, SLC6A4, HTR2A, FKBP5, HTR1A
6fluoxetine49 44 28 1114.4HTR2A, TPH1, SLC6A4, MAOA, HTR1A
75-hydroxytryptamine4411.3SLC6A4, HTR1A, HTR2A, MAOA, TPH1
8mdma4411.3TPH1, SLC6A4, HTR1A, MAOA
9escitalopram44 49 11 2414.3FKBP5, HTR2A, SLC6A4, HTR1A
10antidepressants4911.3HTR1A, HTR2A, FKBP5, TPH1
115-hydroxytryptophan4411.3TPH1, HTR1A, HTR2A, SLC6A4
12nefazodone44 49 1113.3HTR1A, HTR2A, FKBP5, SLC6A4
13mianserin28 44 1113.3HTR2A, SLC6A4, HTR1A, MAOA
14fenfluramine28 44 1113.3HTR1A, SLC6A4, HTR2A, TPH1
15venlafaxine49 44 11 2414.3HTR1A, FKBP5, SLC6A4, HTR2A
16amitriptyline44 49 28 1114.3HTR1A, HTR2A, MAOA, SLC6A4
17desipramine44 49 1113.2HTR2A, HTR1A, MAOA, SLC6A4
18imipramine44 49 28 11 2415.2HTR1A, HTR2A, MAOA, SLC6A4
19p-chlorophenylalanine4411.2SLC6A4, HTR1A, TPH1
208-hydroxy-2-(di-n-propylamino)tetralin4411.2SLC6A4, HTR1A, HTR2A
21bufotenine28 44 1113.2MAOA, HTR1A, HTR2A
22p-chloroamphetamine4411.2SLC6A4, MAOA, HTR1A
23carbon-114411.2HTR1A, MAOA, SLC6A4
24norepinephrine44 11 2413.2HTR2A, HTR1A, MAOA, SLC6A4, TPH1
25m-chlorophenylpiperazine4411.2HTR1A, SLC6A4, HTR2A
26naratriptan44 28 1113.2MAOA, HTR2A, HTR1A
27MMDA1111.2MAOA, HTR2A, SLC6A4
28mcpp4411.1SLC6A4, HTR1A, HTR2A
29minaprine44 1112.1MAOA, HTR2A, SLC6A4
30pindolol44 28 1113.1HTR1A, HTR2A, SLC6A4
31trazodone44 28 1113.1HTR1A, HTR2A, SLC6A4
32trimipramine49 44 1113.1HTR2A, HTR1A, SLC6A4
33methysergide44 28 1113.1HTR1A, HTR2A, MAOA
34sertraline44 28 49 11 2415.1HTR1A, SLC6A4, MAOA
35homovanillic acid44 2412.1TPH1, SLC6A4, MAOA
36ketanserin28 4412.1HTR2A, HTR1A, SLC6A4
375-hydroxyindoleacetic acid44 2412.1TPH1, SLC6A4, MAOA
38doxepin44 28 49 1114.1HTR1A, HTR2A, SLC6A4
39nortriptyline44 49 28 1114.0HTR2A, HTR1A, SLC6A4
40sumatriptan44 28 59 49 11 2416.0HTR2A, HTR1A, MAOA
41phenylpiperazine4410.9HTR2A, HTR1A
425,7-dihydroxytryptamine4410.9HTR2A, SLC6A4
43Cinitapride1110.9HTR2A, HTR1A
44urapidil4410.8HTR1A, HTR2A
45phenylbiguanide4410.8HTR1A, HTR2A
46ergoline4410.7HTR2A, HTR1A
47perospirone4410.7HTR2A, HTR1A
48way 1006354410.7HTR1A, HTR2A
49lysergic acid diethylamide4410.6HTR2A, HTR1A
50alpha-methylserotonin4410.4HTR2A, HTR1A

GO Terms for genes affiliated with Major Depressive Disorder

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Sources:
16Gene Ontology
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Biological processes related to Major Depressive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.7HTR2A, HTR1A
2vasoconstrictionGO:04231010.7SLC6A4, HTR1A
3serotonin receptor signaling pathwayGO:00721010.6HTR2A, HTR1A
4regulation of behaviorGO:05079510.4HTR2A, HTR1A

Products for genes affiliated with Major Depressive Disorder

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Sources for Major Depressive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet