MCID: MJR001
MIFTS: 50

Major Depressive Disorder malady

Mental diseases category
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Summaries for Major Depressive Disorder

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Disease Ontology:8 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

MalaCards based summary: Major Depressive Disorder, also known as single major depressive episode, is related to attention deficit hyperactivity disorder and major depressive disorder and accelerated response to antidepressant drug treatment. An important gene associated with Major Depressive Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled). The compounds selective serotonin reuptake inhibitors and nefazodone have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes.

Wikipedia:65 Major depressive disorder (MDD) (also known as clinical depression, major depression, unipolar... more...

Aliases & Classifications for Major Depressive Disorder

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Major Depressive Disorder, Aliases & Descriptions:

Name: Major Depressive Disorder 30 8 9 22 10 62
Single Major Depressive Episode 8 62
 
Recurrent Major Depressive Episodes 62
Recurrent Major Depression 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Related Diseases for Major Depressive Disorder

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Diseases in the Major Depressive Disorder family:

Major Depressive Disorder 1 Major Depressive Disorder 2

Diseases related to Major Depressive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 97)
idRelated DiseaseScoreTop Affiliating Genes
1attention deficit hyperactivity disorder31.0HTR2A
2major depressive disorder and accelerated response to antidepressant drug treatment30.5BP51, FKBP5
3bipolar disorder10.9
4anxiety disorder10.8
5schizophrenia10.8
6generalized anxiety disorder10.8
7panic disorder10.8
8blindness10.8
9mood disorder10.6
10personality disorder10.6
11bipolar i disorder10.6
12dysthymic disorder10.6
13borderline personality disorder10.5
14melancholia10.4
15obsessive-compulsive disorder10.4
16neuronitis10.4
17alexithymia10.4
18cerebritis10.4
19hypersomnia10.4
20diabetes mellitus10.3
21obesity10.3
22post-traumatic stress disorder10.3
23nicotine dependence10.3
24dementia10.3
25endogenous depression10.3
26major depressive disorder 110.3
27major depressive disorder 210.3
28endotheliitis10.3
29alzheimer's disease10.2
30parkinson's disease10.2
31spinal cord injury10.2
32conduct disorder10.2
33adjustment disorder10.2
34postpartum depression10.2
35alcohol dependence10.2
36chronic fatigue syndrome10.2
37eating disorder10.2
38thyroiditis10.2
39ataxia10.2
40chronic pain10.2
41major depressive disorder, response to citalopram therapy in10.2
42acoustic neuroma10.1
43dystonia10.1
44neuroma10.1
45acne10.1
46alopecia10.1
47brain injury10.1
48cerebellar ataxia10.1
49hepatitis10.1
50huntington's disease10.1

Graphical network of the top 20 diseases related to Major Depressive Disorder:



Diseases related to major depressive disorder

Symptoms for Major Depressive Disorder

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Drugs & Therapeutics for Major Depressive Disorder

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Drug clinical trials:

Search ClinicalTrials for Major Depressive Disorder

Search NIH Clinical Center for Major Depressive Disorder

Genetic Tests for Major Depressive Disorder

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Genetic tests related to Major Depressive Disorder:

id Genetic test Affiliating Genes
1 Major Depressive Disorder22

Anatomical Context for Major Depressive Disorder

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MalaCards organs/tissues related to Major Depressive Disorder:

32
Brain, Cortex, Testes, Prefrontal cortex, Bone, Amygdala, Cingulate cortex, Pituitary, Heart, Monocytes, Endothelial, Spinal cord, Thyroid, Temporal lobe, Breast, T cells, Thalamus

Animal Models for Major Depressive Disorder or affiliated genes

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Publications for Major Depressive Disorder

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Articles related to Major Depressive Disorder:

(show top 50)    (show all 946)
idTitleAuthorsYear
1
The relationship between change in apathy and changes in cognition and functional outcomes in currently non-depressed SSRI-treated patients with major depressive disorder. (24268564)
2014
2
Meta-analysis of the association between N-methyl-d-aspartate receptor antibodies and schizophrenia, schizoaffective disorder, bipolar disorder, and major depressive disorder. (24882425)
2014
3
Comment on the prescription of exercise for major depressive disorder: reply to Drs. Rethorst and Trivedi. (23852100)
2013
4
Distinguishing bipolar II depression from major depressive disorder with comorbid borderline personality disorder: demographic, clinical, and family history differences. (24107761)
2013
5
Negative life events and corticotropin-releasing-hormone receptor1 gene in recurrent major depressive disorder. (23529111)
2013
6
Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder. (23813968)
2013
7
Changes in Heart Rate Variability before and after ECT in the Treatment of Resistant Major Depressive Disorder. (24029110)
2013
8
Differential impact of isolated psychotic symptoms on treatment outcome of major depressive disorder in the STAR*D cohort of Whites, Blacks and Latinos. (23489398)
2013
9
Psychotic versus non-psychotic major depressive disorder: a comparative naturalistic study. (23810143)
2013
10
Functional connectivity between the amygdala and prefrontal cortex in medication-naive individuals with major depressive disorder. (24148846)
2013
11
Is there a cerebellar compensatory effort in first-episode, treatment-naive major depressive disorder at rest? (23800464)
2013
12
The serotonin transporter gene locus in late-life major depressive disorder. (23290204)
2013
13
Obsessive beliefs in patients with major depressive disorder. (24164496)
2013
14
Randomized, double-blind study of the efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in elderly patients with major depressive disorder. (23567397)
2013
15
Whole-brain functional connectivity during emotional word classification in medication-free Major Depressive Disorder: Abnormal salience circuitry and relations to positive emotionality. (24179829)
2013
16
Effectiveness and cost effectiveness of guided online treatment for patients with major depressive disorder on a waiting list for psychotherapy: study protocol of a randomized controlled trial. (24289099)
2013
17
Sexual functioning in patients with major depressive disorder in randomized placebo-controlled studies of extended release quetiapine fumarate. (24067192)
2013
18
Antidepressant treatment reduces serotonin-1A autoreceptor binding in major depressive disorder. (23374637)
2013
19
Longitudinal analysis of healthcare costs: a case study of patients with major depressive disorder treated with duloxetine. (23425292)
2013
20
The effect of escitalopram on metabolic parameters in patients with major depressive disorder, generalised anxiety disorder, and panic disorder: a prospective 6-month follow-up study. (23642988)
2013
21
Adjunctive aripiprazole therapy with escitalopram in patients with co-morbid major depressive disorder and alcohol dependence: clinical and neuroimaging evidence. (23325372)
2013
22
Agomelatine treatment of major depressive disorder in Parkinson's disease: a case series. (24247862)
2013
23
Vilazodone hydrochloride, a combined SSRI and 5-HT1A receptor agonist for major depressive disorder. (23229074)
2012
24
Phenotypic differences between pregnancy-onset and postpartum-onset major depressive disorder. (23290332)
2012
25
Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorder. (22609366)
2012
26
The role of single nucleotide polymorphism of D2 dopamine receptor gene on major depressive disorder and response to antidepressant treatment. (22796099)
2012
27
Increased symptoms of attention deficit hyperactivity disorder and major depressive disorder symptoms in Nail-patella syndrome: potential association with LMX1B loss-of-function. (21184584)
2011
28
Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. (20439149)
2010
29
Association analysis of SIGMAR1 with major depressive disorder and SSRI response. (20178807)
2010
30
Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals. (20726698)
2010
31
Dysbindin gene (DTNBP1) in major depressive disorder (MDD) patients: lack of association with clinical phenotypes. (20822372)
2010
32
The role of clinical variables, neuropsychological performance and SLC6A4 and COMT gene polymorphisms on the prediction of early response to fluoxetine in major depressive disorder. (20584552)
2010
33
Efficacy, safety, and tolerability of Desvenlafaxine 50 mg/d for the treatment of major depressive disorder:a systematic review of clinical trials. (20944767)
2010
34
Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder. (19900711)
2010
35
Duplication of the SLIT3 locus on 5q35.1 predisposes to major depressive disorder. (21152026)
2010
36
Desvenlafaxine succinate for major depressive disorder: a critical review of the evidence. (19086875)
2008
37
Association of chronic hepatitis C with major depressive disorders: irrespective of interferon-alpha therapy. (17956625)
2007
38
Comparing postpartum depression and major depressive disorder: issues in assessment. (17654110)
2007
39
Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder. (17346943)
2007
40
Major depressive disorder, sleep EEG and agomelatine: an open-label study. (17477886)
2007
41
Catechol-o-methyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response. (17417063)
2007
42
Number of risk genotypes is a risk factor for major depressive disorder: a case control study. (16822313)
2006
43
Neurocognitive differential diagnosis of dementing diseases: Alzheimer's Dementia, Vascular Dementia, Frontotemporal Dementia, and Major Depressive Disorder. (17000529)
2006
44
Aripiprazole augmentation of selective serotonin reuptake inhibitors for treatment-resistant major depressive disorder. (16259548)
2005
45
Neurokinin-1 receptors are decreased in major depressive disorder. (12151774)
2002
46
Monoamine oxidase: A gene polymorphism, tryptophan hydroxylase gene polymorphism and antidepressant response to fluvoxamine in Japanese patients with major depressive disorder. (12502014)
2002
47
Tryptophan hydroxylase gene 218A/C polymorphism is associated with somatic anxiety in major depressive disorder. (11426508)
2001
48
Antidepressant drug exposure is associated with mRNA levels of tyrosine receptor kinase B in major depressive disorder. (11041531)
2000
49
Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder. (10440460)
1999
50
Fast onset: an open study of the treatment of major depressive disorder with nefazodone and pindolol combination therapy. (9219044)
1997

Variations for Major Depressive Disorder

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Expression for genes affiliated with Major Depressive Disorder

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Expression patterns in normal tissues for genes affiliated with Major Depressive Disorder

Search GEO for disease gene expression data for Major Depressive Disorder.

Pathways for genes affiliated with Major Depressive Disorder

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Compounds for genes affiliated with Major Depressive Disorder

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Sources:
50PharmGKB, 44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Major Depressive Disorder according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1selective serotonin reuptake inhibitors5010.3HTR2A, FKBP5
2nefazodone44 50 1112.3HTR2A, FKBP5
3antidepressants5010.2HTR2A, FKBP5
4escitalopram44 50 24 1113.2FKBP5, HTR2A
5mirtazapine44 50 1112.2HTR2A, FKBP5
6clomipramine44 50 1112.1FKBP5, HTR2A
7venlafaxine44 50 24 1113.1FKBP5, HTR2A
8citalopram44 50 24 1113.1HTR2A, FKBP5
9paroxetine44 50 28 1113.0HTR2A, FKBP5
10fluoxetine44 50 28 1112.8HTR2A, FKBP5

GO Terms for genes affiliated with Major Depressive Disorder

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Cellular components related to Major Depressive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1caveolaGO:00590110.1HTR2A, LRP8

Products for genes affiliated with Major Depressive Disorder

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  • Antibodies
  • Proteins
  • Lysates

Sources for Major Depressive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet