MCID: MJR001
MIFTS: 58

Major Depressive Disorder malady

Summaries for Major Depressive Disorder

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

MalaCards: Major Depressive Disorder, also known as single major depressive episode, is related to bipolar disorder and anxiety disorder. An important gene associated with Major Depressive Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are SIDS Susceptibility Pathways and Circadian entrainment. The compounds paroxetine and citalopram have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes.

Wikipedia:63 Major depressive disorder (MDD) (also known as clinical depression, major depression, unipolar... more...

Aliases & Classifications for Major Depressive Disorder

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Sources:
8Disease Ontology, 9diseasecard, 22GTR, 10DISEASES, 60UMLS, 27ICD9CM, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

major depressive disorder 8 9 22 10 60
single major depressive episode 8 60
recurrent major depressive episodes 60
recurrent major depression 8


Related Diseases for Major Depressive Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Major Depressive Disorder family:

Major Depressive Disorder 1 Major Depressive Disorder 2

Diseases related to Major Depressive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.3SLC6A4, HTR2A
2anxiety disorder31.2HTR1A, HTR2A, TPH1, SLC6A4, MAOA
3schizophrenia31.1SLC6A4, MAOA, HTR1A, HTR2A, TPH1
4panic disorder31.1SLC6A4, HTR1A
5generalized anxiety disorder31.1HTR1A, SLC6A4
6personality disorder31.0SLC6A4, TPH1, MAOA
7mood disorder31.0TPH1, SLC6A4, HTR1A, MAOA, HTR2A
8dysthymic disorder30.8HTR2A, MAOA
9psychotic disorder30.7HTR1A, HTR2A, MAOA, TPH1, SLC6A4
10borderline personality disorder30.7SLC6A4, MAOA, TPH1
11melancholia30.5MAOA
12obsessive-compulsive disorder30.5HTR2A, HTR1A, MAOA, SLC6A4, TPH1
13attention deficit hyperactivity disorder30.4MAOA, SLC6A4, HTR2A
14alcohol dependence30.4MAOA, HTR2A, SLC6A4
15eating disorder30.4HTR1A, HTR2A, SLC6A4
16dementia30.4MAOA, HTR2A, HTR1A
17endogenous depression30.4MAOA
18chronic fatigue syndrome30.3MAOA, HTR1A, SLC6A4
19major depressive disorder and accelerated response to antidepressant drug treatment30.3BP51, FKBP5
20conduct disorder30.2SLC6A4, MAOA
21parkinson's disease30.2HTR1A, MAOA
22nicotine dependence30.2SLC6A4
23schizoaffective disorder30.1SLC6A4, HTR2A
24anorexia nervosa30.0TPH1, SLC6A4, MAOA, HTR2A, HTR1A
25seasonal affective disorder30.0HTR1A, TPH1, SLC6A4, HTR2A
26gilles de la tourette syndrome30.0SLC6A4, MAOA, HTR1A, HTR2A
27substance dependence30.0SLC6A4, TPH1
28agoraphobia30.0HTR1A, MAOA
29pain disorder10.6
30sleep disorder10.6
31atypical depressive disorder10.5
32bipolar i disorder10.5
33sexual disorder10.5
34somatization disorder10.4
35neuronitis10.4
36mental depression10.4
37postpartum depression10.3
38alexithymia10.3
39cerebritis10.3
40adjustment disorder10.3
41alzheimer's disease10.3
42post-traumatic stress disorder10.3
43brain disease10.3
44diabetes mellitus10.3
45obesity10.3
46physical disorder10.3
47major depressive disorder 110.3
48major depressive disorder 210.3
49cocaine dependence10.2
50rumination disorder10.2

Graphical network of the top 20 diseases related to Major Depressive Disorder:



Diseases related to major depressive disorder

Clinical Features for Major Depressive Disorder

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Drugs & Therapeutics for Major Depressive Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Major Depressive Disorder

Drug clinical trials:

Search ClinicalTrials for Major Depressive Disorder

Search NIH Clinical Center for Major Depressive Disorder

Search CenterWatch for Major Depressive Disorder

Genetic Tests for Major Depressive Disorder

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Sources:
22GTR
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Genetic tests related to Major Depressive Disorder:

id Genetic test Affiliating Genes
1 Major Depressive Disorder22

Anatomical Context for Major Depressive Disorder

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Sources:
32MalaCards
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MalaCards organs/tissues related to Major Depressive Disorder:

32
Brain, Cortex, Testes, Prefrontal cortex, Amygdala, Bone, Pituitary, Cingulate cortex, Endothelial, Monocytes, Heart, Thyroid, Ovary, Spinal cord, Temporal lobe, T cells, Breast, Thalamus, Cerebellum

Animal Models for Major Depressive Disorder or affiliated genes

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Publications for Major Depressive Disorder

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Sources:
50PubMed
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Articles related to Major Depressive Disorder:

(show top 50)    (show all 1061)
idTitleAuthorsYear
1
The relationship between change in apathy and changes in cognition and functional outcomes in currently non-depressed SSRI-treated patients with major depressive disorder. (24268564)
2014
2
A Phase III, Double-Blind, Placebo-Controlled, Flexible-Dose Study of Levomilnacipran Extended-Release in Patients With Major Depressive Disorder. (24172209)
2014
3
CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population. (24262814)
2014
4
DATA-DRIVEN COURSE TRAJECTORIES IN PRIMARY CARE PATIENTS WITH MAJOR DEPRESSIVE DISORDER. (24390862)
2014
5
The discrepancy between patients and informants on clinician-rated measures in major depressive disorder: implications for clinical trials and clinical practice. (24216755)
2014
6
Randomized, double-blind study of the efficacy and tolerability of extended release quetiapine fumarate (quetiapine XR) monotherapy in elderly patients with major depressive disorder. (23567397)
2013
7
Expression of GABAA I+2-, I^1- and I/-receptors are altered significantly in the lateral cerebellum of subjects with schizophrenia, major depression and bipolar disorder. (24022508)
2013
8
Effect of propofol versus sodium thiopental on electroconvulsive therapy in major depressive disorder: a randomized double-blind controlled clinical trial. (23377746)
2013
9
Relief of depression and pain improves daily functioning and quality of life in patients with major depressive disorder. (23989033)
2013
10
The effectiveness of individual interpersonal psychotherapy as a treatment for major depressive disorder in adult outpatients: a systematic review. (23312024)
2013
11
Predicting relapse in major depressive disorder using patient-reported outcomes of depressive symptom severity, functioning, and quality of life in the individual burden of illness index for depression (IBI-D). (23790554)
2013
12
Major Depressive Disorder Is Associated with Abnormal Interoceptive Activity and Functional Connectivity in the Insula. (24387823)
2013
13
Pharmacotherapy of suicidal behaviour in major depression, schizophrenia and bipolar disorder. (24308257)
2013
14
No evidence for an involvement of copy number variation in ABCA13 in schizophrenia, bipolar disorder, or major depressive disorder. (23250005)
2013
15
An open-label, rater-blinded, 8-week trial of bupropion hydrochloride extended-release in patients with major depressive disorder with atypical features. (23963965)
2013
16
Bone mineral density and bone metabolism in patients with major depressive disorder without somatic comorbidities. (23380173)
2013
17
Length of psychiatric hospitalization is correlated with CYP2D6 functional status in inpatients with major depressive disorder. (23734807)
2013
18
Changes in the neural correlates of implicit emotional face processing during antidepressant treatment in major depressive disorder. (23809145)
2013
19
Rational site-directed pharmacotherapy for major depressive disorder. (23745670)
2013
20
Sexual functioning in patients with recurrent major depressive disorder enrolled in the PREVENT study. (23538970)
2013
21
Efficacy and safety of levomilnacipran sustained release in moderate to severe major depressive disorder: a randomized, double-blind, placebo-controlled, proof-of-concept study. (23656841)
2013
22
Comparison of neuropsychological functioning and emotional processing in major depression and social anxiety disorder subjects, and matched healthy controls. (22711880)
2012
23
An investigation of different aspects of overgeneralization in patients with major depressive disorder and borderline personality disorder. (23078209)
2012
24
DAOA variants on diagnosis and response to treatment in patients with major depressive disorder and bipolar disorder. (22429365)
2012
25
Intimate partner violence against adult women and its association with major depressive disorder, depressive symptoms and postpartum depression: a systematic review and meta-analysis. (22694991)
2012
26
Temperament and character dimensions and their relationship to major depression and panic disorder. (23429781)
2012
27
Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in Japanese patients with major depressive disorder (MDD). (22883353)
2012
28
Genetic polymorphisms in the serotonergic system and symptom clusters of major depressive disorder. (21917318)
2011
29
Serotonin transporter polymorphism in major depressive disorder (MDD), psychiatric disorders, and in MDD in response to stressful life events: causes and treatment with antidepressant. (22021682)
2011
30
Replacement of homologous mouse DNA sequence with pathogenic 6-base human CREB1 promoter sequence creates murine model of major depressive disorder. (21598377)
2011
31
Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. (18982004)
2010
32
Age-related changes of n-3 and n-6 polyunsaturated fatty acids in the anterior cingulate cortex of individuals with major depressive disorder. (20060277)
2010
33
Transforming growth factor-beta1 and major depressive disorder with and without attempted suicide: preliminary study. (20452036)
2010
34
The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study. (20531207)
2010
35
Association study of astrocyte-derived protein S100B gene polymorphisms with major depressive disorder in Chinese people. (19497163)
2009
36
Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. (19181679)
2009
37
CLOCK may predict the response to fluvoxamine treatment in Japanese major depressive disorder patients. (19347611)
2009
38
Meta-analyses of genetic studies on major depressive disorder. (17938638)
2008
39
Agomelatine treatment of major depressive disorder. (19033480)
2008
40
Differential etiology of posttraumatic stress disorder with conduct disorder and major depression in male veterans. (17617384)
2007
41
Gene expression profiling in postmortem prefrontal cortex of major depressive disorder. (18045927)
2007
42
Hippocampal FGF-2 and FGFR1 mRNA expression in major depression, schizophrenia and bipolar disorder. (16861106)
2006
43
Disordered adrenocorticotropin secretion in women with major depression. (16478816)
2006
44
Association between enhanced soluble CD40 ligand and proinflammatory and prothrombotic states in major depressive disorder: pilot observations on the effects of selective serotonin reuptake inhibitor therapy. (17196057)
2006
45
Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use. (15466676)
2004
46
Association study of a brain-derived neurotrophic-factor genetic polymorphism and major depressive disorders, symptomatology, and antidepressant response. (14582140)
2003
47
Possible association between -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population. (12960751)
2003
48
Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. (12496953)
2003
49
Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. (10483058)
1999
50
Cortisol measures in primary major depressive disorder with hypersomnia or appetite increase. (2975683)
1988

Genetic Variations for Major Depressive Disorder

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Expression for genes affiliated with Major Depressive Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Major Depressive Disorder

Search GEO for disease gene expression data for Major Depressive Disorder.

Pathways for genes affiliated with Major Depressive Disorder

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Sources:
37NCBI BioSystems Database, 29KEGG, 49PharmGKB, 53Reactome
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Compounds for genes affiliated with Major Depressive Disorder

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Major Depressive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1paroxetine44 49 28 1114.5HTR2A, SLC6A4, HTR1A, TPH1, MAOA, FKBP5
2citalopram49 44 11 2414.5TPH1, SLC6A4, HTR2A, FKBP5, MAOA, HTR1A
3maoa4411.4TPH1, SLC6A4, HTR2A, HTR1A, MAOA
4fluvoxamine44 49 1113.4MAOA, HTR1A, HTR2A, TPH1, SLC6A4
5clomipramine44 49 1113.4MAOA, SLC6A4, HTR2A, FKBP5, HTR1A
6fluoxetine49 44 28 1114.4HTR2A, TPH1, SLC6A4, MAOA, HTR1A
75-hydroxytryptamine4411.3SLC6A4, HTR1A, HTR2A, MAOA, TPH1
8mdma4411.3TPH1, SLC6A4, HTR1A, MAOA
9escitalopram44 49 11 2414.3FKBP5, HTR2A, SLC6A4, HTR1A
10antidepressants4911.3HTR1A, HTR2A, FKBP5, TPH1
115-hydroxytryptophan4411.3TPH1, HTR1A, HTR2A, SLC6A4
12nefazodone44 49 1113.3HTR1A, HTR2A, FKBP5, SLC6A4
13mianserin28 44 1113.3HTR2A, SLC6A4, HTR1A, MAOA
14fenfluramine28 44 1113.3HTR1A, SLC6A4, HTR2A, TPH1
15venlafaxine49 44 11 2414.3HTR1A, FKBP5, SLC6A4, HTR2A
16amitriptyline44 49 28 1114.3HTR1A, HTR2A, MAOA, SLC6A4
17desipramine44 49 1113.2HTR2A, HTR1A, MAOA, SLC6A4
18imipramine44 49 28 11 2415.2HTR1A, HTR2A, MAOA, SLC6A4
19p-chlorophenylalanine4411.2SLC6A4, HTR1A, TPH1
208-hydroxy-2-(di-n-propylamino)tetralin4411.2SLC6A4, HTR1A, HTR2A
21bufotenine28 44 1113.2MAOA, HTR1A, HTR2A
22p-chloroamphetamine4411.2SLC6A4, MAOA, HTR1A
23carbon-114411.2HTR1A, MAOA, SLC6A4
24norepinephrine44 11 2413.2HTR2A, HTR1A, MAOA, SLC6A4, TPH1
25m-chlorophenylpiperazine4411.2HTR1A, SLC6A4, HTR2A
26naratriptan44 28 1113.2MAOA, HTR2A, HTR1A
27MMDA1111.2MAOA, HTR2A, SLC6A4
28mcpp4411.1SLC6A4, HTR1A, HTR2A
29minaprine44 1112.1MAOA, HTR2A, SLC6A4
30pindolol44 28 1113.1HTR1A, HTR2A, SLC6A4
31trazodone44 28 1113.1HTR1A, HTR2A, SLC6A4
32trimipramine49 44 1113.1HTR2A, HTR1A, SLC6A4
33methysergide44 28 1113.1HTR1A, HTR2A, MAOA
34sertraline44 28 49 11 2415.1HTR1A, SLC6A4, MAOA
35homovanillic acid44 2412.1TPH1, SLC6A4, MAOA
36ketanserin28 4412.1HTR2A, HTR1A, SLC6A4
375-hydroxyindoleacetic acid44 2412.1TPH1, SLC6A4, MAOA
38doxepin44 28 49 1114.1HTR1A, HTR2A, SLC6A4
39nortriptyline44 49 28 1114.0HTR2A, HTR1A, SLC6A4
40sumatriptan44 28 59 49 11 2416.0HTR2A, HTR1A, MAOA
41phenylpiperazine4410.9HTR2A, HTR1A
425,7-dihydroxytryptamine4410.9HTR2A, SLC6A4
43Cinitapride1110.9HTR2A, HTR1A
44urapidil4410.8HTR1A, HTR2A
45phenylbiguanide4410.8HTR1A, HTR2A
46ergoline4410.7HTR2A, HTR1A
47perospirone4410.7HTR2A, HTR1A
48s 169242810.7HTR2A, HTR1A
49lysergic acid diethylamide4410.6HTR2A, HTR1A
50alpha-methylserotonin4410.4HTR2A, HTR1A

GO Terms for genes affiliated with Major Depressive Disorder

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Sources:
16Gene Ontology
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Biological processes related to Major Depressive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.7HTR2A, HTR1A
2vasoconstrictionGO:04231010.7SLC6A4, HTR1A
3serotonin receptor signaling pathwayGO:00721010.6HTR2A, HTR1A
4regulation of behaviorGO:05079510.4HTR2A, HTR1A

Products for genes affiliated with Major Depressive Disorder

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  • Antibodies
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Sources for Major Depressive Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet