MCID: MJR001
MIFTS: 58

Major Depressive Disorder malady

Summaries for Major Depressive Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

MalaCards: Major Depressive Disorder, also known as single major depressive episode, is related to bipolar disorder and anxiety disorder. An important gene associated with Major Depressive Disorder is HTR2A (5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled), and among its related pathways are SIDS Susceptibility Pathways and Circadian entrainment. The compounds paroxetine and citalopram have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and whole blood.

Wikipedia:64 Major depressive disorder (MDD) (also known as clinical depression, major depression, unipolar... more...

Aliases & Classifications for Major Depressive Disorder

Sources:
8Disease Ontology, 9diseasecard, 22GTR, 10DISEASES, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

major depressive disorder 8 9 22 10 61
single major depressive episode 8 61
recurrent major depressive episodes 61
recurrent major depression 8


Related Diseases for Major Depressive Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Major Depressive Disorder family:

major depressive disorder 1 major depressive disorder 2

Diseases related to Major Depressive Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1bipolar disorder31.4SLC6A4, HTR2A
2anxiety disorder31.3HTR1A, HTR2A, TPH1, SLC6A4, MAOA
3panic disorder31.1SLC6A4, HTR1A
4generalized anxiety disorder31.1HTR1A, SLC6A4
5dysthymic disorder30.8HTR2A, MAOA
6borderline personality disorder30.7SLC6A4, MAOA, TPH1
7melancholia30.6MAOA
8obsessive-compulsive disorder30.5HTR2A, HTR1A, MAOA, SLC6A4, TPH1
9attention deficit hyperactivity disorder30.4MAOA, SLC6A4, HTR2A
10alcohol dependence30.4MAOA, HTR2A, SLC6A4
11chronic fatigue syndrome30.3MAOA, HTR1A, SLC6A4
12major depressive disorder and accelerated response to antidepressant drug treatment30.3BP51, FKBP5
13conduct disorder30.3SLC6A4, MAOA
14nicotine dependence30.3SLC6A4
15schizoaffective disorder30.1SLC6A4, HTR2A
16anorexia nervosa30.1TPH1, SLC6A4, MAOA, HTR2A, HTR1A
17seasonal affective disorder30.1HTR1A, TPH1, SLC6A4, HTR2A
18serotonin syndrome30.1MAOA, HTR2A, HTR1A
19substance dependence30.1SLC6A4, TPH1
20parkinson's disease30.1HTR1A, MAOA
21agoraphobia30.1HTR1A, MAOA
22major depressive disorder 110.7
23sleep disorder10.6
24pain disorder10.6
25bipolar i disorder10.6
26atypical depressive disorder10.6
27major depressive disorder 210.6
28alexithymia10.4
29post-traumatic stress disorder10.4
30hypersomnia10.4
31adjustment disorder10.3
32n syndrome10.3
33brain disease10.3
34postpartum depression10.2
35cocaine dependence10.2
36rumination disorder10.2
37ataxia10.2
38chronic pain10.2
39seizure disorder10.2
40spinal cord injury10.2
41major depressive disorder, response to citalopram therapy in10.2
42acoustic neuroma10.1
43prolactinoma10.1
44vascular dementia10.1
45paranoid schizophrenia10.1
46conversion disorder10.1
47cannabis dependence10.1
48hepatitis c10.1
49thalamic disease10.1
50temporal lobe epilepsy10.1

Graphical network of the top 20 diseases related to Major Depressive Disorder:



Diseases related to major depressive disorder

Clinical Features for Major Depressive Disorder

Drugs & Therapeutics for Major Depressive Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Major Depressive Disorder

Drug clinical trials:

Search ClinicalTrials for Major Depressive Disorder

Search NIH Clinical Center for Major Depressive Disorder

Search CenterWatch for Major Depressive Disorder

Genetic Tests for Major Depressive Disorder

Sources:
22GTR
See all sources

Genetic tests related to Major Depressive Disorder:

id Genetic test Affiliating Genes
1 Major Depressive Disorder22

Anatomical Context for Major Depressive Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Major Depressive Disorder:

33
Spinal cord, Brain, Whole blood, Cortex, Heart, Thyroid, Breast, Monocytes, Nk cells, T cells, B cells, Endothelial, Prefrontal cortex, Cingulate cortex, Parietal lobe, Temporal lobe, Thalamus, Amygdala, Adrenal cortex, Pituitary

Animal Models for Major Depressive Disorder or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Major Depressive Disorder

Sources:
51PubMed
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Articles related to Major Depressive Disorder:

(show top 50)    (show all 927)
idTitleAuthorsYear
1
Pericardial, intra-abdominal, and subcutaneous adipose tissue in patients with major depressive disorder. (24433292)
2014
2
From Stress to Inflammation and Major Depressive Disorder: A Social Signal Transduction Theory of Depression. (24417575)
2014
3
Pooled analysis of adjunct extended-release quetiapine fumarate in patients with major depressive disorder according to ongoing SSRI or SNRI treatment. (24108148)
2014
4
Neural correlates of free T3 alteration after catecholamine depletion in subjects with remitted major depressive disorder and in controls. (23954912)
2014
5
Major depressive disorder symptoms in male and female young adults. (23651450)
2014
6
Differential impact of isolated psychotic symptoms on treatment outcome of major depressive disorder in the STAR*D cohort of Whites, Blacks and Latinos. (23489398)
2013
7
Epistatic interaction between CRHR1 and AVPR1b variants as a predictor of major depressive disorder. (23962971)
2013
8
Acute working memory improvement after tDCS in antidepressant-free patients with major depressive disorder. (23370288)
2013
9
Genome-wide association analysis accounting for environmental factors through propensity-score matching: application to stressful live events in major depressive disorder. (23857890)
2013
10
Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: a pilot fMRI study. (24080517)
2013
11
Trigeminal nerve stimulation in major depressive disorder: acute outcomes in an open pilot study. (23773978)
2013
12
Acute phase cognitive therapy for recurrent major depressive disorder: who drops out and how much do patient skills influence response? (23485420)
2013
13
Relief of depression and pain improves daily functioning and quality of life in patients with major depressive disorder. (23989033)
2013
14
Local control for identifying subgroups of interest in observational research: persistence of treatment for major depressive disorder. (23956114)
2013
15
Gender-specific suicide risk factors: a case-control study of individuals with major depressive disorder. (24434089)
2013
16
Predictors of depressive symptoms at hospital discharge in patients with major depressive disorder. (23428235)
2013
17
No support for a role for BDNF gene polymorphisms rs11030101 and rs61888800 in major depressive disorder or antidepressant response in patients of Finnish origin. (23250003)
2013
18
Psychotherapy, antidepressants, and their combination for chronic major depressive disorder: a systematic review. (23870720)
2013
19
Major depressive disorder in Africa and the Middle East: a systematic literature review. (24138647)
2013
20
Azapirone 5-HT1A receptor partial agonist treatment for major depressive disorder: systematic review and meta-analysis. (24262766)
2013
21
Quality of life in patients with major depressive disorder. (23715339)
2013
22
Brain Biopsy Findings Link Major Depressive Disorder to Neuroinflammation, Oxidative Stress, and Neurovascular Dysfunction: A Case Report. (24075735)
2013
23
Temporal discounting in major depressive disorder. (24176142)
2013
24
Screening for major depressive disorder in adults with cerebral glioma: an initial validation of 3 self-report instruments. (23229997)
2013
25
Interpersonal sensitivity associated with return to work status following sick leave: a cross-sectional study among Japanese workers with major depressive disorder. (23466112)
2013
26
Adjunctive pregabalin in partial responders with major depressive disorder and residual anxiety. (23277244)
2013
27
Adjunctive atypical antipsychotic treatment for major depressive disorder: a meta-analysis of depression, quality of life, and safety outcomes. (23554581)
2013
28
Real-world, open-label study to evaluate the effectiveness of mirtazapine on sleep quality in outpatients with major depressive disorder. (23857869)
2013
29
Association of serum homocysteine with major depressive disorder: results from a large population-based study. (23707477)
2013
30
Association between major depressive disorder and the norepinephrine transporter polymorphisms T-182C and G1287A: a meta-analysis. (23648227)
2013
31
Vilazodone hydrochloride, a combined SSRI and 5-HT1A receptor agonist for major depressive disorder. (23229074)
2012
32
Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population. (21993442)
2012
33
Increases in amplitude of low-frequency fluctuations in left fronto-parietal area after duloxetine therapy in first-episode, drug-naA^ve, major depressive disorder with panic disorder patients. (23037667)
2012
34
Genome-wide association study of recurrent early-onset major depressive disorder. (20125088)
2011
35
Agomelatine for the treatment of major depressive disorder. (21916789)
2011
36
Effect of short-term antidepressant treatment on early maladaptive schemas in patients with major depressive and panic disorder. (22121857)
2011
37
Efficacy, safety, and tolerability of Desvenlafaxine 50 mg/d for the treatment of major depressive disorder:a systematic review of clinical trials. (20944767)
2010
38
Association of the adrenergic alpha 2a receptor--1291C/G polymorphism with weight change and treatment response to mirtazapine in patients with major depressive disorder. (19401164)
2009
39
Sex-specific interaction between MAOA promoter polymorphism and Apo epsilon 2 allele in major depressive disorder in the Chinese population. (19859025)
2009
40
Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder. (19593178)
2009
41
Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population. (18785206)
2009
42
Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder. (17964051)
2008
43
Meta-analyses of genetic studies on major depressive disorder. (17938638)
2008
44
Brain metabolic changes associated with predispotion to onset of major depressive disorder and adjustment disorder in cancer patients--a preliminary PET study. (16684544)
2007
45
Association study of two serotonin 1A receptor gene polymorphisms and fluoxetine treatment response in Chinese major depressive disorders. (16458487)
2006
46
Analysis of SNP profiles in patients with major depressive disorder. (15927089)
2006
47
Aripiprazole augmentation of antidepressants for the treatment of partially responding and nonresponding patients with major depressive disorder. (16259533)
2005
48
Monocyte chemoattractant protein-1 (MCP1) promoter -2518 polymorphism may confer a susceptibility to major depressive disorder in the Korean population. (15296827)
2004
49
Beclomethasone-induced vasoconstriction in women with major depressive disorder. (14517580)
2003
50
Psychosocial characteristics of adolescents with a past history of dysthymic disorder: comparison with adolescents with past histories of major depressive and non-affective disorders, and never mentally ill controls. (9105954)
1997

Genetic Variations for Major Depressive Disorder

Expression for genes affiliated with Major Depressive Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Major Depressive Disorder

Search GEO for disease gene expression data for Major Depressive Disorder.

Pathways for genes affiliated with Major Depressive Disorder

Sources:
38NCBI BioSystems Database, 30KEGG, 50PharmGKB, 54Reactome
See all sources

Compounds for genes affiliated with Major Depressive Disorder

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Major Depressive Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1paroxetine45 50 29 1114.5HTR2A, SLC6A4, HTR1A, TPH1, MAOA, FKBP5
2citalopram50 45 11 2414.5TPH1, SLC6A4, HTR2A, FKBP5, MAOA, HTR1A
3maoa4511.4TPH1, SLC6A4, HTR2A, HTR1A, MAOA
4fluvoxamine45 50 1113.4MAOA, HTR1A, HTR2A, TPH1, SLC6A4
5clomipramine45 50 1113.4MAOA, SLC6A4, HTR2A, FKBP5, HTR1A
6fluoxetine50 45 29 1114.4HTR2A, TPH1, SLC6A4, MAOA, HTR1A
75-hydroxytryptamine4511.3SLC6A4, HTR1A, HTR2A, MAOA, TPH1
8mdma4511.3TPH1, SLC6A4, HTR1A, MAOA
9escitalopram45 50 11 2414.3FKBP5, HTR2A, SLC6A4, HTR1A
10antidepressants5011.3HTR1A, HTR2A, FKBP5, TPH1
115-hydroxytryptophan4511.3TPH1, HTR1A, HTR2A, SLC6A4
12nefazodone45 50 1113.3HTR1A, HTR2A, FKBP5, SLC6A4
13mianserin29 45 1113.3HTR2A, SLC6A4, HTR1A, MAOA
14fenfluramine29 45 1113.3HTR1A, SLC6A4, HTR2A, TPH1
15venlafaxine50 45 11 2414.3HTR1A, FKBP5, SLC6A4, HTR2A
16amitriptyline45 50 29 1114.3HTR1A, HTR2A, MAOA, SLC6A4
17desipramine45 50 1113.2HTR2A, HTR1A, MAOA, SLC6A4
18imipramine45 50 29 11 2415.2HTR1A, HTR2A, MAOA, SLC6A4
19p-chlorophenylalanine4511.2SLC6A4, HTR1A, TPH1
208-hydroxy-2-(di-n-propylamino)tetralin4511.2SLC6A4, HTR1A, HTR2A
21bufotenine29 45 1113.2MAOA, HTR1A, HTR2A
22p-chloroamphetamine4511.2SLC6A4, MAOA, HTR1A
23carbon-114511.2HTR1A, MAOA, SLC6A4
24norepinephrine45 11 2413.2HTR2A, HTR1A, MAOA, SLC6A4, TPH1
25m-chlorophenylpiperazine4511.2HTR1A, SLC6A4, HTR2A
26naratriptan45 29 1113.2MAOA, HTR2A, HTR1A
27MMDA1111.2MAOA, HTR2A, SLC6A4
28mcpp4511.1SLC6A4, HTR1A, HTR2A
29minaprine45 1112.1MAOA, HTR2A, SLC6A4
30pindolol45 29 1113.1HTR1A, HTR2A, SLC6A4
31trazodone45 29 1113.1HTR1A, HTR2A, SLC6A4
32trimipramine50 45 1113.1HTR2A, HTR1A, SLC6A4
33methysergide45 29 1113.1HTR1A, HTR2A, MAOA
34sertraline45 29 50 11 2415.1HTR1A, SLC6A4, MAOA
35homovanillic acid45 2412.1TPH1, SLC6A4, MAOA
36ketanserin29 4512.1HTR2A, HTR1A, SLC6A4
375-hydroxyindoleacetic acid45 2412.1TPH1, SLC6A4, MAOA
38doxepin45 29 50 1114.1HTR2A, SLC6A4, HTR1A
39nortriptyline45 50 29 1114.0HTR1A, HTR2A, SLC6A4
40sumatriptan45 29 60 50 11 2416.0HTR2A, HTR1A, MAOA
415,7-dihydroxytryptamine4510.9HTR2A, SLC6A4
42phenylpiperazine4510.9HTR2A, HTR1A
43urapidil4510.9HTR1A, HTR2A
44Cinitapride1110.8HTR2A, HTR1A
45phenylbiguanide4510.8HTR1A, HTR2A
46alpha-methylserotonin4510.7HTR1A, HTR2A
47lysergic acid diethylamide4510.7HTR1A, HTR2A
48lsd2910.7HTR2A, HTR1A
49perospirone4510.6HTR1A, HTR2A
50ergoline4510.4HTR1A, HTR2A

GO Terms for genes affiliated with Major Depressive Disorder

Sources:
16Gene Ontology
See all sources

Biological processes related to Major Depressive Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of hormone secretionGO:04688310.7HTR2A, HTR1A
2vasoconstrictionGO:04231010.7SLC6A4, HTR1A
3serotonin receptor signaling pathwayGO:00721010.6HTR2A, HTR1A
4regulation of behaviorGO:05079510.4HTR2A, HTR1A

Products for genes affiliated with Major Depressive Disorder

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Sources for Major Depressive Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet