MCID: MJR011
MIFTS: 34

Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment malady

Genetic diseases (common) category

Aliases & Classifications for Major Depressive Disorder and Accelerated Response to...

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Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment, Aliases & Descriptions:

Name: Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment 45
Major Depressive Disorder 45 30 9 10 11 22 60
Seasonal Affective Disorder 45 9 43 32 60
Major Depressive Disorder 1 45 10 22 60
Major Depressive Disorder 2 45 10 22 60
Unipolar Depression 45 43 60
 
Single Major Depressive Episode 9 60
Winter Depression 9 60
Major Depressive Disorder, Response to Citalopram Therapy in 45
Recurrent Major Depressive Episodes 60
Recurrent Major Depression 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Summaries for Major Depressive Disorder and Accelerated Response to...

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MedlinePlus:32 Some people experience a serious mood change during the winter months, when there is less natural sunlight. this condition is called seasonal affective disorder, or sad. sad is a type of depression. it usually lifts during spring and summer. not everyone with sad has the same symptoms. they include sad, anxious or "empty" feelings feelings of hopelessness and/or pessimism feelings of guilt, worthlessness or helplessness irritability, restlessness loss of interest or pleasure in activities you used to enjoy fatigue and decreased energy difficulty concentrating, remembering details and making decisions difficulty sleeping or oversleeping changes in weight thoughts of death or suicide sad may be effectively treated with light therapy. but nearly half of people with sad do not respond to light therapy alone. antidepressant medicines and talk therapy can reduce sad symptoms, either alone or combined with light therapy. nih: national institute of mental health

MalaCards based summary: Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment, also known as major depressive disorder, is related to anxiety disorder and panic disorder. An important gene associated with Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment is FKBP5 (FK506 binding protein 5), and among its related pathways are Development Endothelin 1 EDNRA signaling and Circadian entrainment. The compounds selective serotonin reuptake inhibitors and nefazodone have been mentioned in the context of this disorder.

Disease Ontology:9 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

Description from OMIM:45 608516

Related Diseases for Major Depressive Disorder and Accelerated Response to...

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Graphical network of the top 20 diseases related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment:



Diseases related to major depressive disorder and accelerated response to antidepressant drug treatment

Symptoms for Major Depressive Disorder and Accelerated Response to...

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Clinical features from OMIM:

608516

Drugs & Therapeutics for Major Depressive Disorder and Accelerated Response to...

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Drug clinical trials:

Search ClinicalTrials for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment

Search NIH Clinical Center for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment

Genetic Tests for Major Depressive Disorder and Accelerated Response to...

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Genetic tests related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment:

id Genetic test Affiliating Genes
1 Major Depressive Disorder22
2 Major Depressive Disorder 122
3 Major Depressive Disorder 222

Anatomical Context for Major Depressive Disorder and Accelerated Response to...

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Animal Models for Major Depressive Disorder and Accelerated Response to... or affiliated genes

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Publications for Major Depressive Disorder and Accelerated Response to...

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Variations for Major Depressive Disorder and Accelerated Response to...

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Expression for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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LifeMap Discovery
Genes differentially expressed in tissues of Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment patients vs. healthy controls: 30
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ANKRD34Bankyrin repeat domain 34BBlood+3.740.000
2NTSR1neurotensin receptor 1 (high affinity)Blood+3.740.000

Search GEO for disease gene expression data for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment.

Pathways for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Pathways related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling FAK signaling58
Development Endothelin 1 EDNRA transactivation of EGFR58
9.6HTR2A, FKBP5
2
Show member pathways
9.5HTR2A, TPH2
39.5HTR2A, TPH2
49.5HTR2A, TPH2

Compounds for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Sources:
49PharmGKB, 43Novoseek, 12DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1selective serotonin reuptake inhibitors499.8HTR2A, FKBP5
2nefazodone43 49 1211.8FKBP5, HTR2A
3escitalopram43 49 24 1212.7HTR2A, FKBP5
4maoa439.6HTR2A, TPH2
5clomipramine43 49 1211.6FKBP5, HTR2A
6fenfluramine43 28 1211.6HTR2A, TPH2
7paroxetine43 49 28 1212.5HTR2A, FKBP5
85-hydroxytryptamine439.5HTR2A, TPH2
9antidepressants499.4HTR2A, FKBP5, TPH2
10mirtazapine43 49 1211.3HTR2A, FKBP5, TPH2
11venlafaxine43 49 24 1212.3TPH2, FKBP5, HTR2A
12fluoxetine43 49 28 1212.3HTR2A, FKBP5, TPH2
13citalopram43 49 24 1212.3HTR2A, FKBP5

GO Terms for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Products for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Major Depressive Disorder and Accelerated Response to...

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet