MCID: MJR011
MIFTS: 34

Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment malady

Genetic diseases (common) category

Aliases & Classifications for Major Depressive Disorder and Accelerated Response to...

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Aliases & Descriptions for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment:

Name: Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment 46
Major Depressive Disorder 46 30 8 9 10 22 61
Seasonal Affective Disorder 46 8 44 32 61
Major Depressive Disorder 1 46 9 22 61
Major Depressive Disorder 2 46 9 22 61
Unipolar Depression 46 44 61
 
Single Major Depressive Episode 8 61
Winter Depression 8 61
Major Depressive Disorder, Response to Citalopram Therapy in 46
Recurrent Major Depressive Episodes 61
Recurrent Major Depression 8


Classifications:



Summaries for Major Depressive Disorder and Accelerated Response to...

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MedlinePlus:32 Some people experience a serious mood change during the winter months, when there is less natural sunlight. this condition is called seasonal affective disorder, or sad. sad is a type of depression. it usually lifts during spring and summer. not everyone with sad has the same symptoms. they include sad, anxious or "empty" feelings feelings of hopelessness and/or pessimism feelings of guilt, worthlessness or helplessness irritability, restlessness loss of interest or pleasure in activities you used to enjoy fatigue and decreased energy difficulty concentrating, remembering details and making decisions difficulty sleeping or oversleeping changes in weight thoughts of death or suicide sad may be effectively treated with light therapy. but nearly half of people with sad do not respond to light therapy alone. antidepressant medicines and talk therapy can reduce sad symptoms, either alone or combined with light therapy. nih: national institute of mental health

MalaCards based summary: Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment, also known as major depressive disorder, is related to anxiety disorder and panic disorder. An important gene associated with Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment is FKBP5 (FK506 binding protein 5), and among its related pathways are Development Endothelin 1 EDNRA signaling and Circadian entrainment. The compounds selective serotonin reuptake inhibitors and nefazodone have been mentioned in the context of this disorder.

Disease Ontology:8 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

Description from OMIM:46 608516

Related Diseases for Major Depressive Disorder and Accelerated Response to...

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Graphical network of the top 20 diseases related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment:



Diseases related to major depressive disorder and accelerated response to antidepressant drug treatment

Symptoms for Major Depressive Disorder and Accelerated Response to...

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Clinical features from OMIM:

608516

Drugs & Therapeutics for Major Depressive Disorder and Accelerated Response to...

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Drug clinical trials:

Search ClinicalTrials for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment

Search NIH Clinical Center for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment

Genetic Tests for Major Depressive Disorder and Accelerated Response to...

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Genetic tests related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment:

id Genetic test Affiliating Genes
1 Major Depressive Disorder22
2 Major Depressive Disorder 122
3 Major Depressive Disorder 222

Anatomical Context for Major Depressive Disorder and Accelerated Response to...

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Animal Models for Major Depressive Disorder and Accelerated Response to... or affiliated genes

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Publications for Major Depressive Disorder and Accelerated Response to...

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Variations for Major Depressive Disorder and Accelerated Response to...

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Expression for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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LifeMap Discovery
Genes differentially expressed in tissues of Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment patients vs. healthy controls: 30
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ANKRD34Bankyrin repeat domain 34BBlood+3.740.000
2NTSR1neurotensin receptor 1 (high affinity)Blood+3.740.000

Search GEO for disease gene expression data for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment.

Pathways for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Pathways related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling FAK signaling59
Development Endothelin 1 EDNRA transactivation of EGFR59
9.6HTR2A, FKBP5
2
Show member pathways
9.5HTR2A, TPH2
39.5HTR2A, TPH2
49.5HTR2A, TPH2

Compounds for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Sources:
50PharmGKB, 44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
See all sources

Compounds related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment according to GeneCards Suite gene sharing:

(show all 13)
idCompoundScoreTop Affiliating Genes
1selective serotonin reuptake inhibitors509.8HTR2A, FKBP5
2nefazodone44 50 1111.8FKBP5, HTR2A
3escitalopram44 50 24 1112.7HTR2A, FKBP5
4maoa449.6HTR2A, TPH2
5clomipramine44 50 1111.6FKBP5, HTR2A
6fenfluramine44 28 1111.6HTR2A, TPH2
7paroxetine44 50 28 1112.5HTR2A, FKBP5
85-hydroxytryptamine449.5HTR2A, TPH2
9antidepressants509.4HTR2A, FKBP5, TPH2
10mirtazapine44 50 1111.3HTR2A, FKBP5, TPH2
11venlafaxine44 50 24 1112.3TPH2, FKBP5, HTR2A
12fluoxetine44 50 28 1112.3HTR2A, FKBP5, TPH2
13citalopram44 50 24 1112.3HTR2A, FKBP5

GO Terms for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Sources for Major Depressive Disorder and Accelerated Response to...

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet