MCID: MJR011
MIFTS: 37

Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment malady

Genetic diseases (common) category

Summaries for Major Depressive Disorder and Accelerated Response to...

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MedlinePlus:34 Some people experience a serious mood change during the winter months, when there is less natural sunlight. this condition is called seasonal affective disorder, or sad. sad is a type of depression. it usually lifts during spring and summer. not everyone with sad has the same symptoms. they include sad, anxious or "empty" feelings feelings of hopelessness and/or pessimism feelings of guilt, worthlessness or helplessness irritability, restlessness loss of interest or pleasure in activities you used to enjoy fatigue and decreased energy difficulty concentrating, remembering details and making decisions difficulty sleeping or oversleeping changes in weight thoughts of death or suicide sad may be effectively treated with light therapy. but nearly half of people with sad do not respond to light therapy alone. antidepressant medicines and talk therapy can reduce sad symptoms, either alone or combined with light therapy. nih: national institute of mental health

MalaCards based summary: Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment, also known as major depressive disorder, is related to anxiety disorder and bipolar disorder. An important gene associated with Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment is FKBP5 (FK506 binding protein 5), and among its related pathways are Development Endothelin 1 EDNRA signaling and Circadian entrainment. The compounds selective serotonin reuptake inhibitors and nefazodone have been mentioned in the context of this disorder.

Disease Ontology:10 An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities.

Description from OMIM:47 608516

Aliases & Classifications for Major Depressive Disorder and Accelerated Response to...

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Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment, Aliases & Descriptions:

Name: Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment 47
Major Depressive Disorder 47 32 10 11 12 24
Seasonal Affective Disorder 47 10 45 34
Major Depressive Disorder 2 47 11 24
Major Depressive Disorder 1 47 11 24
 
Unipolar Depression 47 45
Major Depressive Disorder, Response to Citalopram Therapy in 47
Single Major Depressive Episode 10
Recurrent Major Depression 10
Winter Depression 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


Related Diseases for Major Depressive Disorder and Accelerated Response to...

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Graphical network of the top 20 diseases related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment:



Diseases related to major depressive disorder and accelerated response to antidepressant drug treatment

Symptoms for Major Depressive Disorder and Accelerated Response to...

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Clinical features from OMIM:

608516

Drugs & Therapeutics for Major Depressive Disorder and Accelerated Response to...

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Drug clinical trials:

Search ClinicalTrials for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment

Search NIH Clinical Center for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment

Genetic Tests for Major Depressive Disorder and Accelerated Response to...

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Genetic tests related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment:

id Genetic test Affiliating Genes
1 Major Depressive Disorder24
2 Major Depressive Disorder 124
3 Major Depressive Disorder 224

Anatomical Context for Major Depressive Disorder and Accelerated Response to...

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Animal Models for Major Depressive Disorder and Accelerated Response to... or affiliated genes

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Publications for Major Depressive Disorder and Accelerated Response to...

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Variations for Major Depressive Disorder and Accelerated Response to...

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Expression for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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LifeMap Discovery
Genes differentially expressed in tissues of Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment patients vs. healthy controls: 32 (show all 2)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ANKRD34Bankyrin repeat domain 34BBlood+3.740.000
2NTSR1neurotensin receptor 1 (high affinity)Blood+3.740.000


Search GEO for disease gene expression data for Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment.

Pathways for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Pathways related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
9.6HTR2A, FKBP5
2
Show member pathways
9.5HTR2A, TPH2
39.5HTR2A, TPH2
49.5HTR2A, TPH2

Compounds for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Sources:
51PharmGKB, 45Novoseek, 13DrugBank, 26HMDB, 30IUPHAR
See all sources

Compounds related to Major Depressive Disorder and Accelerated Response to Antidepressant Drug Treatment according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1selective serotonin reuptake inhibitors519.8HTR2A, FKBP5
2nefazodone45 51 1311.8FKBP5, HTR2A
3escitalopram45 51 26 1312.7HTR2A, FKBP5
4maoa459.6HTR2A, TPH2
5clomipramine45 51 1311.6FKBP5, HTR2A
6fenfluramine45 30 1311.6HTR2A, TPH2
7paroxetine45 51 30 1312.5HTR2A, FKBP5
85-hydroxytryptamine459.5HTR2A, TPH2
9antidepressants519.4HTR2A, FKBP5, TPH2
10mirtazapine45 51 1311.3HTR2A, FKBP5, TPH2
11venlafaxine45 51 26 1312.3TPH2, FKBP5, HTR2A
12fluoxetine45 51 30 1312.3HTR2A, FKBP5, TPH2
13citalopram45 51 26 1312.3HTR2A, FKBP5

GO Terms for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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Products for genes affiliated with Major Depressive Disorder and Accelerated Response to...

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Major Depressive Disorder and Accelerated Response to...

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet