MCID: MLR004
MIFTS: 75

Malaria malady

Rare diseases, Infectious diseases categories
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Summaries for Malaria

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8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 4CDC, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Malaria is a serious disease caused by a parasite. you get it when an infected mosquito bites you. malaria is a major cause of death worldwide, but it is almost wiped out in the united states. the disease is mostly a problem in developing countries with warm climates. if you travel to these countries, you are at risk. there are four different types of malaria caused by four related parasites. the most deadly type occurs in africa south of the sahara desert. malaria symptoms include chills, flu-like symptoms, fever, vomiting, diarrhea, and jaundice. a blood test can diagnose it. it can be life-threatening. however, you can treat malaria with drugs. the type of drug depends on which kind of malaria you have and where you were infected. malaria can be prevented. when traveling to malaria-prone regions see your doctor for medicines that protect you wear insect repellent with deet cover up sleep under mosquito netting centers for disease control and prevention

MalaCards: Malaria, also known as induced malaria, is related to plasmodium falciparum malaria and cerebral malaria. An important gene associated with Malaria is NOS2 (nitric oxide synthase 2, inducible), and among its related pathways are Malaria and Tuberculosis. The drugs hydroxychloroquine and hydroxychloroquine sulfate and the compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

NIH Rare Diseases:43 Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. people who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. in general, malaria is a curable disease if diagnosed and treated promptly and correctly. treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired. last updated: 5/12/2011

CDC:4 Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 219 million cases of malaria occurred worldwide and 660,000 people died, most (91%) in the African Region.

Wikipedia:65 Malaria is a mosquito-borne infectious disease of humans and other animals caused by parasitic... more...

Description from OMIM:47 611162

Aliases & Classifications for Malaria

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8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Aliases & Descriptions:

malaria 8 43 47 10 45 34 62
induced malaria 8 62


External Ids:

Disease Ontology8 DOID:12365
ICD9CM27 084, 084.6
MeSH35 D008288
NCIt40 C34797

Related Diseases for Malaria

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malaria family:

Malaria, Severe

Diseases related to Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 309)
idRelated DiseaseScoreTop Affiliating Genes
1plasmodium falciparum malaria32.1CD36, NOS2, CR1, HP, IL10, IFNG
2cerebral malaria32.1MIF, ICAM1, G6PD, TNF, IFNG, IL10
3plasmodium vivax malaria31.9DARC, G6PD
4thrombocytopenia31.0HP, FCGR2B, FCGR2A
5leishmaniasis30.9IFNG, IL10
6encephalomyelitis30.7TNF, IFNG, IL10, CR1, NOS2
7blackwater fever30.7G6PD
8alpha thalassemia30.7G6PD, HBB
9sepsis30.6TNF, FCGR2A, CISH, MIF, IL10, CR1
10tuberculosis30.5TNF, HBB, MIF, IFNG, IL10, HP
11hemolytic anemia30.5HBB, G6PD, HP, CR1, SLC4A1
12visceral leishmaniasis30.5IFNG, IL10
13hereditary elliptocytosis30.4G6PD, GYPC, SLC4A1
14encephalitis30.4NOS2, GYPC, DARC
15sickle cell disease30.4HP, G6PD, HBB
16deficiency anemia30.4HBB, FCGR2A, G6PD, MIF, HP, CR1
17pneumonia30.4TNF, GYPA, ICAM1, IL10, CR1
18glomerulonephritis30.4FCGR2A, ICAM1, MIF, CR1, NOS2
19adult respiratory distress syndrome30.4TNF, MIF, CR1, NOS2
20systemic lupus erythematosus30.3FCGR2A, CR1
21methemoglobinemia30.3G6PD, HP
22burkitt's lymphoma30.3HBB, FCGR2A, FCGR2B, CISH, ICAM1, IL10
23pre-eclampsia30.2HBB, ICAM1, IL10, HP, NOS2
24sickle cell anemia30.2HP, G6PD, HBB
25hemoglobinopathy30.2HBB, G6PD, HP
26glucosephosphate dehydrogenase deficiency30.2G6PD, HP
27melanoma30.2TNF, FCGR2A, CISH, GYPC, ICAM1, IFNG
28multiple sclerosis30.0TNF, ICAM1, MIF, IFNG, IL10, CR1
29autoimmune hemolytic anemia30.0G6PD, GYPA, HP
30hepatitis b30.0CR1, IL10, IFNG
31psoriasis30.0IL10, IFNG, ICAM1, TNF
32atopy30.0IL10, IFNG, MIF
33favism30.0G6PD, HP
34hemoglobinuria30.0G6PD, HP
35ischemia30.0NOS2, CR1, HP, ICAM1
36leukemia29.9TNF, HBB, CISH, GYPA, ICAM1, IFNG
37asthma29.9TNF, CISH, ICAM1, MIF, IFNG, IL10
38beta thalassemia29.9G6PD, HBB
39cerebritis11.2
40malaria, severe10.7
41plasmodium malariae malaria10.6
42plasmodium ovale malaria10.6
43endotheliitis10.5
44filariasis10.5
45mixed malaria10.5
46schistosomiasis10.5
47blindness10.4
48babesiosis10.4
49hepatitis10.4
50splenomegaly10.4

Graphical network of the top 20 diseases related to Malaria:



Diseases related to malaria

Symptoms for Malaria

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47OMIM
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Clinical features from OMIM:

611162

Drugs & Therapeutics for Malaria

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Malaria

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Anatomical Context for Malaria

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33MalaCards
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MalaCards organs/tissues related to Malaria:

33
Testes, Brain, T cells, Liver, Endothelial, B cells, Monocytes, Spleen, Nk cells, Kidney, Placenta, Whole blood, Myeloid, Bone marrow, Eye, Bone, Cortex, Skin, Cardiac myocytes, Hypothalamus, Pituitary, Skeletal muscle, Heart, Lung, Temporal lobe

Animal Models for Malaria or affiliated genes

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37MGI
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Publications for Malaria

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52PubMed
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Articles related to Malaria:

(show top 50)    (show all 3015)
idTitleAuthorsYear
1
Preliminary Study of Quinine Pharmacokinetics in Pregnant Women with Malaria-HIV Co-Infection. (24420779)
2014
2
Marked Decline in Malaria Prevalence among Pregnant Women and Their Offspring from 1996 to 2010 on the South Kenyan Coast. (24080635)
2013
3
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
4
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. (24218563)
2013
5
Thymine distribution in genes provides novel insight into the functional significance of the proteome of the malaria parasite Plasmodium falciparum 3D7. (24132930)
2013
6
Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice. (24020374)
2013
7
Detection of a substantial number of sub-microscopic Plasmodium falciparum infections by polymerase chain reaction: a potential threat to malaria control and diagnosis in Ethiopia. (24090230)
2013
8
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
9
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. (22326740)
2012
10
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
11
Source of homologous parasites in recurrent Plasmodium vivax malaria. (22696499)
2012
12
Plasmodium berghei ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model. (21044627)
2011
13
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. (21689454)
2011
14
Therapeutic efficacy of chloroquine for treatment of Plasmodium vivax malaria cases in Halaba district, South Ethiopia. (21453465)
2011
15
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria. (21459194)
2011
16
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. (20105282)
2010
17
Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis. (20145098)
2010
18
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
19
The murine cerebral malaria phenomenon. (19932638)
2010
20
Screening mosquito house entry points as a potential method for integrated control of endophagic filariasis, arbovirus and malaria vectors. (20689815)
2010
21
Fluorescein angiography findings strengthen the theoretical basis for trialling neuroprotective agents in cerebral malaria. (19635680)
2009
22
Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas. (18266013)
2008
23
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
24
Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia. (18317566)
2008
25
Markers of vascular endothelial cell damage and P. falciparum malaria: association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation. (18775803)
2008
26
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. (18602399)
2008
27
Polymorphisms of TNF-enhancer and gene for FcgammaRIIa correlate with the severity of falciparum malaria in the ethnically diverse Indian population. (18194515)
2008
28
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. (17997848)
2007
29
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. (17325227)
2007
30
Louse-borne relapsing fever and malaria co-infection in Ethiopia. (17540107)
2007
31
Aquaporin water and solute channels from malaria parasites and other pathogenic protozoa. (16892397)
2006
32
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
33
Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. (17447375)
2006
34
Effects of hydroxyurea on malaria, parasite growth and adhesion in experimental models. (17096647)
2006
35
Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. (16282291)
2005
36
Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance. (15642957)
2004
37
Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors. (15138068)
2004
38
Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. (14573655)
2003
39
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. (12433515)
2002
40
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. (12421634)
2002
41
Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine-pyrimethamine in vivax malaria pilot studies: relationship to Plasmodium vivax dhfr mutations. (12435700)
2002
42
Nitric oxide synthase 2(LambarAcnAc) (G-954C), increased nitric oxide production, and protection against malaria. (11443559)
2001
43
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. (10447880)
1999
44
IgE and tumor necrosis factor in malaria infection. (10065623)
1999
45
Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study. (10589898)
1999
46
Molecular characterization of the heat shock protein 90 gene of the human malaria parasite Plasmodium falciparum. (7838176)
1994
47
Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children. (7899791)
1994
48
Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria. (1565611)
1992
49
Common west African HLA antigens are associated with protection from severe malaria. (1865923)
1991
50
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. (1978068)
1990

Variations for Malaria

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Expression for genes affiliated with Malaria

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malaria

Search GEO for disease gene expression data for Malaria.

Pathways for genes affiliated with Malaria

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 53QIAGEN, 55Reactome, 54R&D Systems
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Pathways related to Malaria according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0CD36, DARC, TNF, HBB, GYPB, GYPC
210.8TNF, FCGR2A, FCGR2B, IFNG, IL10, CR1
3
Show member pathways
10.8TNF, FCGR2A, IFNG, IL10, CR1, NOS2
410.7TNF, FCGR2A, ICAM1, MIF, IFNG, NOS2
510.7TNF, HBB, ICAM1, IFNG, IL10
610.7TNF, ICAM1, MIF, IFNG, NOS2
710.7TNF, GYPA, CR1, CD36
810.7NOS2, IL10, IFNG, TNF
9
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
10.7TNF, IFNG, IL10, NOS2
10
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.7TNF, IFNG, IL10, NOS2
11
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
10.7TNF, FCGR2B, IFNG, IL10
1210.7FCGR2A, FCGR2B, ICAM1, IL10
13
Show member pathways
thioredoxin pathway38
10.7TNF, HBB, ICAM1, IFNG
14
Show member pathways
Immune response MIF in innate immunity response60
10.7TNF, MIF, IFNG, NOS2
1510.7TNF, FCGR2A, FCGR2B, IFNG
16
Show member pathways
10.7TNF, FCGR2B, ICAM1, IFNG
17
Show member pathways
Immune response CD16 signaling in NK cells60
10.7TNF, ICAM1, IFNG, NCR3
18
Show member pathways
10.7TNF, ICAM1, IFNG, IL10
19
Show member pathways
10.6CD36, HP, HBB
2010.6ICAM1, IFNG, NOS2
2110.6NOS2, IL10, TNF
22
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
10.6NOS2, IFNG, TNF
23
Show member pathways
Type III interferon signaling38
10.6IL10, IFNG, CISH
2410.6CD36, FCGR2B, FCGR2A
2510.6HP, ICAM1, TNF
2610.6TNF, IFNG, IL10
27
Show member pathways
10.6IL10, IFNG, TNF
28
Show member pathways
IL27-mediated signaling events38
10.6IL10, IFNG, TNF
2910.6IL10, IFNG, TNF
3010.6IFNG, ICAM1, TNF
3110.6CD36, ICAM1, TNF
32
Show member pathways
10.6HBB, SLC4A1

Compounds for genes affiliated with Malaria

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.5CR1, SLC4A1, HP, MIF, ICAM1, GYPC
2nitric oxide45 24 1113.4IL10, TNF, SLC4A1, NOS2, CR1, HP
3lipid4511.4FCGR2A, TNF, DARC, GYPA, MIF, HP
4serine4511.4FCGR2B, TNF, FCGR2A, HBB, CISH, CD36
5h2o24511.3TNF, NOS2, HBB, FCGR2A, G6PD, CD36
6dexamethasone45 51 29 1114.3TNF, HP, NOS2, CISH, ICAM1, MIF
7endotoxin4511.3ICAM1, MIF, IFNG, TNF, NOS2, HP
8pge24511.3TNF, CD36, NOS2, HP, IL10, MIF
9cycloheximide4511.3NOS2, TNF, HBB, ICAM1, IFNG, IL10
10sb 20358045 6112.2TNF, NOS2, MIF, IFNG, IL10, ICAM1
11natalizumab45 1112.2FCGR2B, IL10, IFNG, ICAM1, FCGR2A, TNF
12actinomycin d4511.2HP, IFNG, ICAM1, G6PD, FCGR2A, TNF
13vegf4511.2MIF, CD36, NOS2, HP, IFNG, TNF
14genistein45 29 61 3 24 1116.2NOS2, TNF, IFNG, MIF, CD36, ICAM1
15herbimycin a45 6112.2NOS2, MIF, IFNG, TNF, ICAM1, CD36
16lactate4511.2HP, TNF, HBB, G6PD, ICAM1, MIF
17adalimumab45 51 1113.2FCGR2B, FCGR2A, IFNG, TNF, IL10
18thymidine45 2412.1IFNG, IL10, MIF, GYPC, FCGR2B, HBB
19polymyxin b4511.1CR1, TNF, ICAM1, IFNG, IL10
20etanercept45 51 1113.1FCGR2B, FCGR2A, TNF, IFNG, IL10
21ivig4511.1TNF, FCGR2A, FCGR2B, IFNG, IL10
22pentoxifylline45 1112.1IL10, TNF, ICAM1, IFNG, HP
23rantes4511.1DARC, IL10, IFNG, MIF, ICAM1, TNF
24interferon gamma4511.1IL10, IFNG, ICAM1, TNF
2515-deoxy-delta-12,14-prostaglandin j24511.1TNF, IFNG, IL10, NOS2, CD36
26neopterin4511.1HP, IFNG, ICAM1, TNF, IL10
27rituximab45 51 1113.1TNF, FCGR2A, FCGR2B, IL10, HP
28ulinastatin4511.1HP, IL10, ICAM1, TNF
29efalizumab45 1112.1TNF, ICAM1, FCGR2B, FCGR2A
30thalidomide45 51 61 1114.1CD36, IFNG, MIF, TNF, IL10
31tuberculin4511.0IFNG, HP, IL10, MIF
32prednisolone45 29 1113.0CR1, IL10, IFNG, FCGR2A, TNF
33oxygen45 2412.0HBB, ICAM1, MIF, FCGR2A, NOS2, CR1
34okt34511.0IFNG, IL10, ICAM1, TNF
35triptolide4511.0TNF, ICAM1, IFNG, NOS2
36hydrocortisone45 3 61 1114.0MIF, CD36, TNF, IFNG, IL10
37gm-csf45 2912.0TNF, ICAM1, IFNG, IL10
38parthenolide45 312.0TNF, ICAM1, IFNG, NOS2
39budesonide45 51 1112.9CD36, IFNG, TNF, ICAM1
40histamine45 29 2412.9TNF, FCGR2B, FCGR2A, ICAM1, IFNG, IL10
41estrogen4510.9NOS2, FCGR2B, CISH, HP, CD36, MIF
42sialic acid4510.9GYPB, HP, MIF, GYPA, GYPC
43sulfasalazine29 45 51 1113.9TNF, G6PD, HP, ICAM1
448-isoprostane4510.9ICAM1, IL10, TNF, HP
45cdp5714510.9IL10, TNF, ICAM1
46polyinosinic-polycytidylic acid4510.8NOS2, IL10, TNF, IFNG
47ly2940024510.8FCGR2A, ICAM1, IL10, TNF, NOS2, CD36
48fmlp4510.7FCGR2B, FCGR2A, TNF, ICAM1, CR1
49mycophenolate mofetil45 51 1112.6TNF, IFNG, IL10, CD36
50diphenyleneiodonium4510.4TNF, ICAM1, NOS2, G6PD

GO Terms for genes affiliated with Malaria

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16Gene Ontology
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Cellular components related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.2CISH, FCGR2B, FCGR2A, TNF, DARC, GYPB
2integral component of plasma membraneGO:00588711.1SLC4A1, TNF, GYPB, GYPC, GYPA, ICAM1
3external side of plasma membraneGO:00989710.9TNF, GYPA, ICAM1, IFNG, CD36
4extracellular vesicular exosomeGO:07006210.9HBB, G6PD, ICAM1, MIF, HP, CR1
5cortical cytoskeletonGO:03086310.8GYPC, NOS2, SLC4A1
6extracellular spaceGO:00561510.7TNF, ICAM1, MIF, IFNG, IL10, HP
7haptoglobin-hemoglobin complexGO:03183810.7HP, HBB
8blood microparticleGO:07256210.6SLC4A1, HP, HBB
9cell surfaceGO:00998610.6TNF, MIF, CR1, CD36
10endocytic vesicle lumenGO:07168210.3HP, HBB

Biological processes related to Malaria according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.1DARC, TNF, MIF, IL10, NCR3, NOS2
2cellular response to lipopolysaccharideGO:07122211.1ICAM1, IFNG, IL10, NOS2, CD36
3negative regulation of growth of symbiont in hostGO:04413011.0CD36, IL10, IFNG, TNF
4positive regulation of nitric oxide biosynthetic processGO:04542911.0IFNG, ICAM1, HBB, TNF
5defense response to bacteriumGO:04274211.0NOS2, HP, IL10, IFNG
6positive regulation of cytokine secretionGO:05071510.9TNF, MIF, IL10
7positive regulation of vitamin D biosynthetic processGO:06055710.9IFNG, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9TNF, IFNG
9positive regulation of killing of cells of other organismGO:05171210.9IFNG, NOS2
10positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9CD36, MIF, ICAM1
11receptor biosynthetic processGO:03280010.9TNF, IL10
12positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.9TNF, MIF
13negative regulation of gene expressionGO:01062910.9TNF, MIF, NOS2
14negative regulation of cytokine secretion involved in immune responseGO:00274010.8IL10, TNF
15response to drugGO:04249310.8TNF, ICAM1, IFNG, IL10
16positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, IFNG
17regulation of insulin secretionGO:05079610.8NOS2, IFNG, TNF
18positive regulation of chemokine biosynthetic processGO:04508010.8IFNG, TNF
19positive regulation of membrane protein ectodomain proteolysisGO:05104410.7IFNG, TNF
20nitric oxide mediated signal transductionGO:00726310.7NOS2, CD36
21positive regulation of osteoclast differentiationGO:04567210.6IFNG, TNF
22negative regulation of interleukin-6 productionGO:03271510.6TNF, IL10
23protein import into nucleus, translocationGO:00006010.6IFNG, TNF
24positive regulation of cell deathGO:01094210.5HBB, HP
25cell surface receptor signaling pathwayGO:00716610.3CD36, IFNG, MIF

Molecular functions related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0HBB, FCGR2B, CISH, G6PD, GYPC, ICAM1
2cytokine activityGO:00512510.7IL10, IFNG, MIF, TNF
3hemoglobin bindingGO:03049210.5HP, HBB
4IgG bindingGO:01986410.3FCGR2A, FCGR2B

Products for genes affiliated with Malaria

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Sources for Malaria

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet