MCID: MLR004
MIFTS: 73

Malaria malady

Summaries for Malaria

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Malaria is a serious disease caused by a parasite. you get it when an infected mosquito bites you. malaria is a major cause of death worldwide, but it is almost wiped out in the united states. the disease is mostly a problem in developing countries with warm climates. if you travel to these countries, you are at risk. there are four different types of malaria caused by four related parasites. the most deadly type occurs in africa south of the sahara desert. malaria symptoms include chills, flu-like symptoms, fever, vomiting, diarrhea, and jaundice. a blood test can diagnose it. it can be life-threatening. however, you can treat malaria with drugs. the type of drug depends on which kind of malaria you have and where you were infected. malaria can be prevented. when traveling to malaria-prone regions see your doctor for medicines that protect you wear insect repellent with deet cover up sleep under mosquito netting centers for disease control and prevention

MalaCards: Malaria, also known as induced malaria, is related to plasmodium falciparum malaria and cerebral malaria. An important gene associated with Malaria is NOS2 (nitric oxide synthase 2, inducible), and among its related pathways are Malaria and Tuberculosis. The drugs hydroxychloroquine and hydroxychloroquine sulfate and the compounds nitric oxide and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

NIH Rare Diseases:42 Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. people who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. in general, malaria is a curable disease if diagnosed and treated promptly and correctly. treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired. last updated: 5/12/2011

CDC:3 Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 219 million cases of malaria occurred worldwide and 660,000 people died, most (91%) in the African Region.

Wikipedia:63 Malaria is a mosquito-borne infectious disease of humans and other animals caused by parasitic... more...

Description from OMIM:46 611162

Aliases & Classifications for Malaria

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

malaria 8 42 46 10 44 33 60
induced malaria 8 60


External Ids:

Disease Ontology8 DOID:12365
MeSH34 D008288
ICD9CM27 084.6, 084
NCIt39 C34797

Related Diseases for Malaria

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malaria family:

Malaria, Severe

Diseases related to Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 329)
idRelated DiseaseScoreTop Affiliating Genes
1plasmodium falciparum malaria31.9IFNG, ICAM1, G6PD, CR1, CD36, SELE
2cerebral malaria31.7ICAM1, CD36
3plasmodium vivax malaria31.6G6PD, DHFR, DARC
4thrombocytopenia30.7HP, FCGR2B
5schistosomiasis30.6IL10, IFNG
6leishmaniasis30.6IFNG, DHFR, IL10
7hepatitis30.5CR1, HP
8encephalomyelitis30.4NOS2, IL10, CR1, IFNG
9blackwater fever30.4G6PD
10alpha thalassemia30.4G6PD, HBB
11pancytopenia30.2DHFR, HP
12deficiency anemia30.2SLC4A1, DHFR, HP, HBB, MIF, CR1
13tuberculosis30.2HP, CR1, HBB, MIF, IFNG, DHFR
14hemolytic anemia30.2SLC4A1, HP, HBB, CR1, G6PD
15chagas disease30.2DHFR
16retinitis30.2GYPC
17visceral leishmaniasis30.2IL10, IFNG
18sickle cell disease30.1SELE, HP, HBB, G6PD
19glomerulonephritis30.1MIF, NOS2, ICAM1, CR1
20encephalitis30.1GYPC, NOS2, DARC
21hereditary elliptocytosis30.1SLC4A1, GYPC, G6PD
22systemic lupus erythematosus30.0MIF, SELE, FCGR2B, IL10, CR1, IFNG
23burkitt's lymphoma30.0CR1, CISH, HBB, ICAM1, DHFR, IL10
24pneumonia30.0ICAM1, DHFR, GYPA, IL10, CR1
25adult respiratory distress syndrome30.0NOS2, MIF, CR1, SELE
26methemoglobinemia30.0G6PD, HP
27lupus erythematosus30.0FCGR2B
28sarcoma30.0DHFR
29myocarditis30.0NOS2
30melanoma29.9DHFR, CD36, IL10, GYPC, IFNG, ICAM1
31asthma29.9NOS2, IL10, IFNG, ICAM1, CR1, SELE
32pre-eclampsia29.9ICAM1, HBB, HP, IL10, NOS2, SELE
33influenza29.9GYPB, CR1, IFNG
34sickle cell anemia29.9HBB, G6PD, HP
35hemoglobinopathy29.9G6PD, HP, HBB
36viral hepatitis29.9G6PD, CISH
37obesity29.9SELE, CISH
38acute pancreatitis29.9IL10, MIF
39eosinophilia29.9IFNG, IL10
40pancreatitis29.9IL10, ICAM1
41vaccinia29.9DARC
42urticaria29.9SELE
43glucosephosphate dehydrogenase deficiency29.9HP, G6PD
44leukemia29.7HBB, GYPA, HP, CR1, CISH, ICAM1
45multiple sclerosis29.7IFNG, ICAM1, IL10, NOS2, CR1, MIF
46psoriasis29.7IFNG, DHFR, ICAM1, IL10, SELE
47ischemia29.7HP, ICAM1, CR1, NOS2, SELE
48atopic dermatitis29.7IL10, MIF, ICAM1, IFNG, SELE
49autoimmune hemolytic anemia29.7HP, G6PD, GYPA
50dermatitis29.7IFNG, SELE, ICAM1

Graphical network of the top 20 diseases related to Malaria:



Diseases related to malaria

Clinical Features for Malaria

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46OMIM
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Clinical features from OMIM:

611162

Drugs & Therapeutics for Malaria

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Malaria

Drug clinical trials:

Search ClinicalTrials for Malaria

Search NIH Clinical Center for Malaria

Search CenterWatch for Malaria

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Malaria

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Anatomical Context for Malaria

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32MalaCards
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MalaCards organs/tissues related to Malaria:

32
Testes, Brain, T cells, Liver, Endothelial, B cells, Monocytes, Nk cells, Spleen, Kidney, Whole blood, Placenta, Myeloid, Bone marrow, Eye, Bone, Cortex, Skin, Cardiac myocytes, Hypothalamus, Pituitary, Skeletal muscle, Heart, Lung, Temporal lobe

Animal Models for Malaria or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malaria:

36 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537614.1CD36, MIF, G6PD, ICAM1, IFNG, HBB
2MP:000539713.9SELE, IFNG, ICAM1, G6PD, MIF, CD36
3MP:000538713.9HBB, CD36, MIF, ICAM1, IFNG, HP
4MP:000538513.7CD36, G6PD, ICAM1, IFNG, HBB, HP
5MP:000538413.6IFNG, ICAM1, G6PD, MIF, CD36, HP
6MP:001076813.4CD36, G6PD, ICAM1, IFNG, HBB, HP
7MP:000537813.2IFNG, ICAM1, G6PD, CD36, HBB, IL10
8MP:000537012.8IFNG, CD36, HBB, HP, IL10, FCGR2B
9MP:000200612.0IFNG, ICAM1, MIF, HP, IL10, NOS2
10MP:000536711.7HBB, HP, FCGR2B, SLC4A1
11MP:001077111.0SLC4A1, HBB
12MP:000539010.7HBB, CD36

Publications for Malaria

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Sources:
50PubMed
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Articles related to Malaria:

(show top 50)    (show all 3043)
idTitleAuthorsYear
1
Diversity, Differentiation, and Linkage Disequilibrium: Prospects for Association Mapping in the Malaria Vector Anopheles arabiensis. (24281424)
2014
2
Antibody Responses to a Novel Plasmodium falciparum Merozoite Surface Protein Vaccine Correlate with Protection against Experimental Malaria Infection in Aotus Monkeys. (24421900)
2014
3
Potent malaria transmission blocking antibody responses elicited by Plasmodium falciparum Pfs25 expressed in E.coli after successful protein refolding. (24421036)
2014
4
Irf8-regulated genomic responses drive pathological inflammation during cerebral malaria. (23853600)
2013
5
Mass drug administration for the control and elimination of Plasmodium vivax malaria: an ecological study from Jiangsu province, China. (24175930)
2013
6
Epidemiology of malaria in South Africa: from control to elimination. (24079633)
2013
7
Primaquine for preventing relapse in people with Plasmodium vivax malaria treated with chloroquine. (24163057)
2013
8
Analysis of Human B cell Responses following ChAd63-MVA MSP1 and AMA1 Immunization and Controlled Malaria Infection. (24303947)
2013
9
Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation. (24284865)
2013
10
Congenital vivax malaria: rare or underdiagnosed infection. (24065517)
2013
11
Malaria (Plasmodium). (24314808)
2013
12
Laboratory tests for malaria: a diagnostic conundrum. (24273787)
2013
13
Disseminated intravascular coagulation following malaria due to Plasmodium vivax: a thromboelastography-based study. (24053759)
2013
14
Neurocognitive sequelae following hippocampal and callosal lesions associated with cerebral malaria in an immune-naive adult. (23893348)
2013
15
Green synthesis of silver nanoparticles for the control of mosquito vectors of malaria, filariasis, and dengue. (22022807)
2012
16
Rapid diagnostic test-based management of malaria: an effectiveness study in Papua New Guinean infants with Plasmodium falciparum and Plasmodium vivax malaria. (22198787)
2012
17
Significant association of KIR2DL3-HLA-C1 combination with cerebral malaria and implications for co-evolution of KIR and HLA. (22412373)
2012
18
Low angiopoietin-1 as a predisposing factor for cerebral vasospasm in cerebral malaria. (23164793)
2012
19
Expressive aphasia: an isolated and reversible complication of cerebral malaria in a child. (22898486)
2012
20
Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. (21904632)
2011
21
A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos. (21118925)
2010
22
Anti-plasmodial effects of Azadirachta indica in experimental cerebral malaria: Apoptosis of cerebellar Purkinje cells of mice as a marker. (22558559)
2010
23
Development of experimental cerebral malaria is independent of IL-23 and IL-17. (21036146)
2010
24
A preliminary study on pro- and anti-inflammatory cytokine profiles in Plasmodium vivax malaria patients from central zone of India. (19958746)
2010
25
The antischistosomal efficacies of artesunate-sulfamethoxypyrazine-pyrimethamine and artemether-lumefantrine administered as treatment for uncomplicated, Plasmodium falciparum malaria. (18186976)
2008
26
Malaria and obesity: obese mice are resistant to cerebral malaria. (18489748)
2008
27
Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria. (18320064)
2008
28
Platelet factor 4 mediates inflammation in experimental cerebral malaria. (18692777)
2008
29
Editorial commentary: mortality associated with severe Plasmodium falciparum malaria increases with age. (18564928)
2008
30
High-performance liquid chromatographic assay for the determination of sulfadoxine and N-acetyl sulfadoxine in plasma from patients infected with sensitive and resistant Plasmodium falciparum malaria. (17997367)
2007
31
Effects of acute Plasmodium falciparum malaria on body weight in children in an endemic area. (17323138)
2007
32
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. (17322885)
2007
33
Rectal artemether versus intravenous quinine for the treatment of cerebral malaria in children in Uganda: randomised clinical trial. (15705690)
2005
34
Plasmodium falciparum clonal population dynamics during malaria treatment. (14722883)
2004
35
Levels of macrophage inflammatory protein 1 alpha (MIP-1 alpha) and MIP-1 beta in intervillous blood plasma samples from women with placental malaria and human immunodeficiency virus infection. (12853396)
2003
36
Host response to malaria during pregnancy: placental monocyte recruitment is associated with elevated beta chemokine expression. (12594307)
2003
37
Efficacy of a 14-day primaquine regimen in preventing relapses in patients with Plasmodium vivax malaria in Mumbai, India. (15259476)
2003
38
Plasma levels of interleukin-12 (IL-12), interleukin-18 (IL-18) and transforming growth factor beta (TGF-beta) in Plasmodium falciparum malaria. (12517727)
2002
39
Spleen size determined by ultrasound in patients with sickle cell trait, HbAC trait and glucose-6-phosphate-dehydrogenase deficiency in a malaria hyperendemic area (Ashanti Region, Ghana). (11600086)
2001
40
Brief communication: Resistance to Falciparum malaria in alpha-thalassemia, oxidative stress, and hemoglobin oxidation. (10378464)
1999
41
A nonhuman primate model for human cerebral malaria: effects of artesunate (qinghaosu derivative) on rhesus monkeys experimentally infected with Plasmodium coatneyi. (7506497)
1993
42
The role of cytokines in Plasmodium vivax malaria. (1343726)
1992
43
More von Willebrand factor type A domains? Sequence similarities with malaria thrombospondin-related anonymous protein, dihydropyridine-sensitive calcium channel and inter-alpha-trypsin inhibitor. (1659389)
1991
44
Myeloid leukemoid reaction in malaria infection. (1820659)
1991
45
Tumour necrosis factor, fever and fatality in falciparum malaria. (2283152)
1990
46
The pathology of human cerebral malaria. (2202227)
1990
47
Plasmodium vivax malaria: parasite biology defines potential targets for vaccine development. (3067803)
1988
48
Chloroquine-resistant Plasmodium vivax malaria in infancy and childhood. (389793)
1979
49
Aleixo de Abreu [1568-1630], author of the earliest book on tropical medicine describing amoebiasis, malaria, typhoid fever, scurvy, yellow fever, dracontiasis, trichuriasis and tungiasis in 1623. (4869639)
1968
50
Malaria and blackwater fever in Macedonia and Thrace in relation to DDT. (18891441)
1948

Genetic Variations for Malaria

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Expression for genes affiliated with Malaria

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malaria

Search GEO for disease gene expression data for Malaria.

Pathways for genes affiliated with Malaria

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Sources:
29KEGG, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database
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Compounds for genes affiliated with Malaria

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB, 49PharmGKB
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Compounds related to Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1nitric oxide44 11 2415.9IL10, NOS2, SLC4A1, HBB, MIF, HP
2tyrosine4413.8DARC, HP, HBB, GYPB, MIF, GYPC
3lipid4413.6GYPA, SLC4A1, G6PD, MIF, GYPC, CISH
4alanine4413.3SELE, DHFR, GYPA, GYPC, MIF, HBB
5lactate4413.1DHFR, HP, MIF, G6PD, ICAM1, SLC4A1
6serine4413.0HBB, FCGR2B, HP, G6PD, SELE, CISH
7h2o24413.0HBB, CD36, HP, DHFR, NOS2, ICAM1
8vegf4413.0IFNG, ICAM1, MIF, CD36, HP, SELE
9sb 20358044 5913.8ICAM1, MIF, IL10, NOS2, SELE, IFNG
10genistein44 28 59 2 11 2417.7ICAM1, SELE, MIF, CD36, FCGR2B, NOS2
11adenylate4412.7NOS2, G6PD, CR1, SELE, HBB, HP
12herbimycin a44 5913.5ICAM1, MIF, CD36, NOS2, IFNG, SELE
13dmso4412.5CR1, CD36, HBB, IL10, SELE, G6PD
14ascorbic acid44 2413.5G6PD, HP, DHFR, NOS2, CD36, ICAM1
15actinomycin d4412.4IFNG, ICAM1, G6PD, HP, NOS2, SELE
16polymyxin b4412.3SELE, IL10, IFNG, CR1, ICAM1
17sialic acid4412.3GYPC, GYPA, GYPB, MIF, SELE
18lactose44 1113.2SELE, G6PD, MIF, HP, DHFR
19thymidine44 2413.1GYPC, FCGR2B, IL10, HBB, MIF, IFNG
20folate4412.1DHFR, SLC4A1, SELE, HP, G6PD
21glyceraldehyde 3-phosphate4412.0HBB, G6PD, SLC4A1, DARC, GYPC
22tuberculin4412.0IL10, HP, MIF, IFNG
23natalizumab44 1113.0FCGR2B, IFNG, ICAM1, IL10
24okt34411.9IL10, ICAM1, SELE, IFNG
25sulfasalazine44 28 49 1114.9G6PD, HP, SELE, ICAM1
268-isoprostane4411.9HP, IL10, SELE, ICAM1
27polyinosinic-polycytidylic acid4411.9SELE, IL10, NOS2, IFNG
28mycophenolate mofetil44 49 1113.9IFNG, IL10, CD36, SELE
29ribavirin44 49 1113.9G6PD, IL10, IFNG, HP
30neopterin4411.8ICAM1, IL10, HP, IFNG
3115-deoxy-delta-12,14-prostaglandin j24411.8IL10, CD36, IFNG, NOS2
32thalidomide44 49 59 1114.7IL10, CD36, MIF, IFNG
33rantes4411.7ICAM1, DARC, IFNG
34chloroquine44 2 49 28 1115.7IL10, G6PD, HP, DHFR
35interferon gamma4411.6IL10, ICAM1, IFNG
36cyclophosphamide44 49 1113.6DHFR, MIF, G6PD
3723-diphosphoglycerate4411.6HP, HBB, G6PD
388 methoxypsoralen4411.6ICAM1, SELE, IL10
39pentamidine44 1112.5IFNG, G6PD, DHFR
40polyethylene glycol4411.5SELE, HP, G6PD, ICAM1
41aspartate4411.5SELE, DHFR, G6PD, HBB
42endotoxin4411.5ICAM1, SELE
43ulinastatin4411.3HP, ICAM1
44pdtc4411.2NOS2, SELE
45adalimumab44 49 1113.2IL10, FCGR2B, IFNG
46cycloheximide4411.2CR1
47estrogen4411.1FCGR2B
48dexamethasone44 49 28 1114.1CISH
49hind iii4411.0CR1, HBB, HP
50pirfenidone44 5911.9CD36

GO Terms for genes affiliated with Malaria

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16Gene Ontology
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Cellular components related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588613.3ICAM1, CR1, CISH, GYPC, GYPA, GYPB
2integral to plasma membraneGO:00588712.7ICAM1, CR1, NCR3, GYPC, GYPA, GYPB
3extracellular spaceGO:00561512.1SELE, IL10, HP, MIF, ICAM1, IFNG
4cortical cytoskeletonGO:03086311.7SELE, NOS2, SLC4A1, GYPC
5external side of plasma membraneGO:00989711.2IFNG, ICAM1, GYPA, CD36
6haptoglobin-hemoglobin complexGO:03183811.0HBB, HP

Biological processes related to Malaria according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695412.2NCR3, MIF, IL10, DARC, NOS2, SELE
2cellular response to lipopolysaccharideGO:07122212.0NOS2, IL10, CD36, ICAM1, IFNG
3defense response to bacteriumGO:04274211.5NOS2, IL10, HP, IFNG
4negative regulation of growth of symbiont in hostGO:04413011.3IFNG, CD36, IL10
5positive regulation of nitric oxide biosynthetic processGO:04542911.2IFNG, ICAM1, HBB
6positive regulation of MHC class II biosynthetic processGO:04534811.0IL10, IFNG
7positive regulation of killing of cells of other organismGO:05171210.7NOS2, IFNG

Molecular functions related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:03049211.0HP, HBB

Products for genes affiliated with Malaria

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet