Malaria malady

MedlinePlus: Malaria is a serious disease caused by a parasite. infected mosquitoes spread it. malaria is a major cause of death worldwide, but it is almost wiped out in the united states. the disease is mostly a problem in developing countries with warm climates. if you travel to these countries, you are at risk. there are four different types of malaria caused by four related parasites. the most deadly type occurs in africa south of the sahara desert. malaria symptoms include chills, flu-like symptoms, fever, vomiting, diarrhea and jaundice. the disease can be life-threatening. however, you can treat malaria with medicines. the type of medicine depends on which kind of malaria you have and where you were infected. malaria can be prevented. when traveling to malaria-prone regions see your doctor for medicines that protect you wear insect repellent with deet cover up sleep under mosquito netting centers for disease control and prevention²³

MalaCards: Malaria, also known as induced malaria, is related to neuronitis and carcinoma. An important gene associated with Malaria is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Metabolic pathways and Spliceosome. The drugs hydroxychloroquine sulfate and hydroxychloroquine and the compounds atp and cysteine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, spleen and brain, and related mouse phenotypes are mortality/aging and embryogenesis.

Disease Ontology: A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.⁶

NIH Rare Diseases: Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. Infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. In general, malaria is a curable disease if diagnosed and treated promptly and correctly. Treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired.³⁰

CDC: Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 216 million cases of malaria occurred worldwide and 655,000 people died, most (91%) in the African Region.²

Wikipedia: Malaria is a mosquito-borne infectious disease of humans and other animals caused by protists (a type of...⁴⁴ more...

OMIM: 611162

Aliases & Descriptions:

malaria 6 30 8 33 32 23 43 induced malaria 6 43

induced malaria (disorder) 6

Diseases related to malaria by text searches and GeneDecks gene sharing:

(show top 50)    (show all 690)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	252.9	ZNF259, PI4KB, PIK3C3, PIM1, LRP1, KLF4
2	carcinoma	189.6	ZNF207, PIM2, PIAS3, PIM3, PIAS1, PIK3C3
3	prostatitis	141.3	ZNF593, PIM2, PIAS2, PIAS3, PIAS4, PIAS1
4	melanoma	139.4	PIM1, LRP1, RFC5, NCL, PDE1C, PDE3A
5	cerebritis	131.4	LRP1, KLF4, PDE4A, REN, CNTF, KITLG
6	leukemia	131.3	PIGA, PIM2, PIAS2, PIAS4, PIAS1, PIM1
7	anemia	130.0	PIGA, PIM1, REN, KITLG, VWF, SF3A1
8	retinitis	118.7	PIGA, PIM1, LRP1, COCH, PDE2A, PDE3B
9	pneumonia	110.8	COASY, PDE4A, CNNM1, CNNM2, CNNM3, CNNM4
10	lupus erythematosus	110.0	WDFY4, NCL, NCR3, RECK, CNTF, VWF
11	pancreatitis	106.8	PIM3, PI4KB, PIM1, LRP1, KLF4, NCL
12	colorectal cancer	105.5	PIGO, LRRC47, LRBA, KLF4, RFC1, RFC3
13	adenocarcinoma	99.5	PIM2, PIM3, PIK3C3, PIM1, LRP1, KLF4
14	alzheimer's disease	98.5	PIP5KL1, PI4KB, PIK3C3, WDFY4, LRP1, RFC1
15	hepatocellular carcinoma	96.7	PIM2, PIM3, WDR16, RFC4, NCL, NCR3
16	gastric cancer	90.6	PIAS1, PIP5KL1, PIM1, COASY, KLF4, NDC80
17	arthritis	84.9	LRP1, RFC1, PDCD5, PDE4A, RECK, CNTF
18	thyroiditis	84.6	WDR3, LRP1, LRRC6, KLF4, RFC1, NCOA7
19	hypoxia	80.2	PIAS4, PIP5KL1, PIM1, WDR26, LRP1, PDCD4
20	rheumatoid arthritis	77.8	LRP1, RFC1, PDCD5, PDE4A, RECK, CNTF
21	ovarian cancer	74.0	LRP1, PDCD4, RECK, KITLG, KIF11, VWF
22	blindness	73.5	PDE4A, REN, CNTF, VWF, RBP4, SELE
23	fibrosis	73.4	PIAS3, LRP1, PDE3A, PDE4A, RECK, REN
24	colon cancer	72.6	PIAS2, PIM3, PIAS1, KLF4, RFC1, PDCD4
25	cholesterol	72.3	ZNF259, PIAS1, PIK3C3, LRP1, PDE1A, PDE3B
26	gonococcal synovitis	69.8	LRP1, KLF4, PDE3B, PDE4A, RECK, CNTF
27	esophagitis	68.3	ZNF207, PIK3C3, PIM1, KLF4, PDCD4, PDCD5
28	neuroblastoma	67.6	PIAS2, LRP1, KLF4, NCL, NCOA7, PDE1C
29	schizophrenia	66.7	PIK3C3, NCOA7, PDE10A, PDE4A, PDE4B, CNTF
30	diabetes mellitus	66.0	LRBA, PDE3B, PDE4A, RECK, REN, VWF
31	homocysteine	65.6	RFC1, REN, VWF, PCNA, PCMT1, GCK
32	hypertension	64.6	PIM1, LRP1, RFC1, PDE3A, PDE3B, PDE4A
33	myeloma	64.0	PIM2, PIAS3, LRP1, PDCD11, PDCD5, PDE4A
34	ataxia	63.3	PIM2, LRP1, VWF, RCN1, PCBP1, PCBP2
35	cervicitis	63.1	PIP5KL1, RFC1, NCL, NCR3, PDCD4, PDE4A
36	atherosclerosis	62.8	WDFY4, LRP1, KLF4, PDE1C, PDE4A, RECK
37	multiple sclerosis	62.4	PIAS1, LRP1, RFC1, RFC2, RFC4, RFC5
38	asthma	62.2	LRP1, PDE10A, PDE11A, PDE3B, PDE4A, PDE4B
39	systemic lupus erythematosus	62.1	NCL, RECK, VWF, RBP4, SELE, VCAM1
40	myeloid leukemia	62.0	PIM2, PIAS4, PIM1, NCL, NCR3, PDCD5
41	sarcoma	61.6	PIAS4, PIK3C3, PDE4A, RECK, REN, REV3L
42	sepsis	60.5	PDE4A, RECK, RBP4, SELE, SELP, SERPINC1
43	pancreatic cancer	60.3	PIM3, LRP1, KLF4, PDE4A, RECK, RECQL
44	obesity	59.6	LRP1, NCR3, PDE10A, PDE3B, RECK, REN
45	breast carcinoma	58.8	LRP1, NDC80, NCL, RECK, KIF1B, KITLG
46	immunodeficiency	58.5	MYD88, BMP6, PARP1, SDHA, CISH, ATP5O
47	leishmaniasis	58.5	KIF2B, MYD88, BMP6, UQCRFS1, MT-CYB, MPI
48	encephalitis	58.0	REV3L, CNTF, SELE, BRSK2, VEGFA, VCAM1
49	ischemia	57.5	WDR26, KLF4, PDE4A, REN, CNTF, KITLG
50	thrombocytopenia	57.5	PIGA, RECK, KITLG, VWF, NBEAL2, SELE

Clinical features from OMIM: 611162

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 hydroxychloroquine, hydroxychloroquine sulfate, sulfadiazine

MalaCards organs/tissues related to malaria:

²²

MGI Mouse Phenotypes related to malaria:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	116.1	ZNF259, PIGA, PIAS4, PIAS1, PIK3C3, LRP1
2	embryogenesis phenotype	MP:0005380	46.4	ZNF259, PIGA, PIK3C3, NCAPG2, RECK, REV3L
3	integument phenotype	MP:0010771	40.7	PIGA, KLF4, PDE3B, RECK, KIF1A, KIF1B
4	liver/biliary system phenotype	MP:0005370	32.8	PIK3C3, RFX5, RECK, SFN, PCYT2, GCK
5	growth/size phenotype	MP:0005378	INF	PIGA, PIM2, PIM3, PIAS1, PIK3C3, PIM1
6	hematopoietic system phenotype	MP:0005397	INF	PIGA, PIM2, PIAS4, PIM3, PIM1, RFX5
7	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C3, LRP1, KLF4, RFK, PDE10A, PDE3B
8	cellular phenotype	MP:0005384	INF	ZNF259, PIGA, PIM2, PIM3, PIK3C3, PIM1
9	cardiovascular system phenotype	MP:0005385	INF	PIK3C3, LRP1, RFX5, PDE4A, PDE4B, RECK
10	tumorigenesis	MP:0002006	INF	PIGA, KLF4, PDCD4, REV3L, KITLG, SF1
11	reproductive system phenotype	MP:0005389	INF	PIGA, KLF4, PDCD4, PDE3A, REN, KIF11
12	immune system phenotype	MP:0005387	INF	PIM2, PIAS4, PIM3, PIAS1, PIK3C3, LRP1
13	muscle phenotype	MP:0005369	INF	PIK3C3, LRP1, REN, RER1, CNOT3, CNTF

Articles related to malaria:

(show top 50)    (show all 909)

id	Title	Authors	Year	Affiliating Genes
1	Molecular correlates of high-level antifolate resista nce in Rwandan children with Plasmodium falciparum malaria. (19841150)	Karema C.... White N.J.	2010	DHFR
2	FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil. (20162434)	Albuquerque S.R.... dos Santos M.C.	2010	DARC
3	Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. (19300530)	Lovegrove F.E.... Kain K.C.	2009	ANGPT1, ANGPT2
4	Genetic polymorphisms of mannose-binding lectin do not influence placental malaria but are associated with preterm deliveries. (19139195)	ThAcvenon A.D.... Taylor D.W.	2009	MBL2
5	Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes. (19403559)	Fry A.E.... Kwiatkowski D.P.	2009	CD36
6	Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria/malaria-coi nfected population. (19561105)	Metenou S.... Nutman T.B.	2009	IL10
7	Endoglin in African children with Plasmodium falcipar um malaria: a novel player in severe malaria pathogenesis? (19919302)	Dietmann A.... Schmutzhard E.	2009	ENG, BMP6
8	Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria. (20003529)	Conroy A.L.... Kain K.C.	2009	ANGPT1, ANGPT2
9	Randomized, double-blind, phase 2a trial of falciparu m malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection. (19569965)	Kester K.E.... Heppner D.G.	2009	CD40LG
10	IL4 gene polymorphism and previous malaria experience s manipulate anti-Plasmodium falciparum antibody isotype profiles in complicate d and uncomplicated malaria. (20003246)	Tangteerawatana P.... Khusmith S.	2009	IL4
11	C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria. (19308263)	Conroy A.... Kain K.C.	2009	TNF, IL6, CCL2
12	Elevated basal hepcidin levels in the liver may inhibit the development of malaria infection: another piece towards solving the malaria puzzle? (17766053)	Oliveras-Verges A.... Espel-Masferrer E.	2008	HAMP
13	Sickle cell trait is associated with a delayed onset of malaria: implications for time-to-event analysis in clinical studies of malaria. (18752444)	Crompton P.D.... Doumbo O.K.	2008	HBB
14	Molecular surveillance for drug-resistant Plasmodiumfalciparum malaria in Malawi. (17544355)	Nkhoma S.... Ward S.	2007	DHFR, DHPS
15	Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria. (17556607)	Awandare G.A.... Perkins D.J.	2007	MIF
16	Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. (17261807)	Parroche P.... Golenbock D.T.	2007	TLR9
17	Stability of interferon-gamma and interleukin-10 responses to Plasmodium falciparum liver stage antigen-1 and thrombospondin-related adhesive protein in residents of a malaria holoendemic area. (16606988)	Moormann A.M.... Kazura J.W.	2006	IFNG, IL10
18	Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naive and malaria-exposed individuals. (16966412)	Bejon P.... Hill A.V.	2006	IL2, IFNG
19	Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria? (16002039)	Amodu O.K.... Omotade O.O.	2005	ICAM1, SELE, CD36
20	Polymorphisms of the HLA-B and HLA-DRB1 genes in Thai malaria patients. (15728986)	Hananantachai H.... Tokunaga K.	2005	HLA-DRB1, HLA-B
21	Host microsatellite alleles in malaria predisposition? (16216127)	Gaikwad S.... Kashyap V.K.	2005	G6PD
22	Abnormal display of PfEMP-1 on erythrocytes carrying haemoglobin C may protect against malaria. (15973412)	Fairhurst R.M.... Wellems T.E.	2005	HBB
23	TNF as a malaria candidate gene: polymorphism-screening and family-based association analysis of mild malaria attack and parasitemia in Burkina Faso. (15931230)	Flori L.... Rihet P.	2005	TNF
24	How malaria has affected the human genome and what hu man genetics can teach us about malaria. (16001361)	Kwiatkowski D.P.	2005	G6PD
25	Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum. (14982635)	Wang P.... Hyde J.E.	2004	DHPS
26	Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism. (15502882)	Keller C.C.... Perkins D.J.	2004	PTGS2, IL10
27	Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. (15385460)	Lyke K.E.... Sztein M.B.	2004	IL10
28	Testing the 'malaria hypothesis' for the case of Thailand: a genetic appraisal. (14655879)	Poolsuwan S.	2003	HBB
29	Mechanism of protection induced by vitamin A in falci parum malaria. (11978340)	Serghides L.... Kain K.C.	2002	TNF, CD36
30	Plasma levels of interleukin-18 and interleukin-12 in Plasmodium falciparum malaria. (12654091)	Malaguarnera L.... Musumeci S.	2002	IL18
31	Immunity to placental malaria. III. Impairment of interleukin(IL)-12, not IL-18, and interferon-inducible protein-10 responses in the placental intervillous blood of human immunodeficiency virus/malaria-coinfected women. (11756993)	Chaisavaneeyakorn S.... Udhayakumar V.	2002	IL18
32	Immunity to placental malaria. IV. Placental malaria is associated with up-regulation of macrophage migration inhibitory factor in intervillous blood. (12402212)	Chaisavaneeyakorn S.... Udhayakumar V.	2002	MIF
33	Strong association of a tumor necrosis factor-alpha promoter allele with cerebral malaria in Myanmar. (11929592)	Ubalee R.... Hirayama K.	2001	TNF, TNFAIP1
34	Genetic epidemiology in the study of susceptibility/resistance to malaria in the human population (10572661)	Abel L.	1999	TNF
35	Immunity to placental malaria. I. Elevated production of interferon-gamma by placental blood mononuclear cells is associated with pr otection in an area with high transmission of malaria. (10191226)	Moore J.M.... Udhayakumar V.	1999	IFNG
36	A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya. (9841855)	Othoro C.... Udhayakumar V.	1999	IFNG, IL10
37	Lack of difference in iron status assessed by soluble transferrin receptor between children with cerebral malaria and those with non-cerebral malaria. (10401196)	Kivibidila S.... Tshefu K.A.	1999	TFRC
38	Influence of malaria on markers of iron status in children: implications for interpreting iron status in malaria-endemic communities. (9389898)	Das B.S.... Das D.B.	1997	TF, ALB
39	Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression. (8760809)	Anstey N.M.... Granger D.L.	1996	IL10
40	Comparison of the number of IL-4 and IFN-gamma secreting cells in response to the malaria vaccine candidate antigen Pf155/RESA in two groups of naturally primed individuals living in a malaria endemic area in Burkina Faso. (7631143)	ElGhazali G.... Troye-Blomberg M.	1995	IFNG
41	The gene encoding topoisomerase I from the human malaria parasite Plasmodium falciparum. (7557466)	Tosh K.... Kilbey B.	1995	TOP1
42	Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. (7935762)	McGuire W.... Kwiatkowski D.	1994	TNF
43	Glycerol metabolism in severe falciparum malaria. (8028514)	Pukrittayakamee S.... Williamson D.H.	1994	INS
44	IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. (8050178)	Perlmann H.... Perlmann P.	1994	IGHE
45	Malaria mimicry with tumor necrosis factor. Contrasts between species of murine malaria and Plasmodium falciparum. (1739126)	Clark I.A.... Cowden W.B.	1992	TNF
46	Interferon-gamma enhances the effect of antimalarial chemotherapy in murine Plasmodium vinckei malaria. (1902249)	Kremsner P.G.... Bienzle U.	1991	IFNG
47	Macrophage activation in vivax malaria: fever is associated with increased levels of neopterin and interferon-gamma. (1811217)	Brown A.E.... Webster H.K.	1991	IFNG
48	Cytokines in the pathogenesis of malaria: levels of IL-I beta, IL-4, IL-6, TNF-alpha and IFN-gamma in plasma of healthy individuals and malaria patients in a holoendemic area. (1667945)	Mshana R.N.... Mendome G.	1991	IFNG
49	Association between immune recognition of the malaria vaccine candidate antigen Pf155/RESA and resistance to clinical disease: a pro spective study in a malaria-endemic region of west Africa. (1755042)	Riley E.M.... Greenwood B.M.	1991	IFNG
50	Effects of interferon in malaria infection. (2126528)	Maheshwari R.K.... Dhawan B.N.	1990	IFNG, IFNA1

Genes related to malaria according to GeneCards:

(show top 50)    (show all 3107)

id	Symbol	Description	Score	GeneCards Section Context
1	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	UniProt Related, Publications, Pathways & Interactions, Summaries
2	HP	haptoglobin	11.0	Publications, Summaries
3	NCR3	natural cytotoxicity triggering receptor 3	11.0	Publications, UniProt Related, Summaries
4	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	11.0	Publications, Summaries
5	FUT9	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	11.0	Publications, Summaries
6	CD36	CD36 molecule (thrombospondin receptor)	11.0	Publications, UniProt Related, Pathways & Interactions
7	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
8	ICAM1	intercellular adhesion molecule 1	10.9	Publications, Functions, UniProt Related, Pathways & Interactions
9	IFNG	interferon, gamma	10.9	Publications, Pathways & Interactions
10	NOS2	nitric oxide synthase 2, inducible	10.9	Publications, UniProt Related
11	DARC	Duffy blood group, chemokine receptor	10.9	Publications, Functions, Pathways & Interactions
12	IL10	interleukin 10	10.9	Publications, Pathways & Interactions
13	TNF	tumor necrosis factor	10.9	Publications, UniProt Related, Pathways & Interactions
14	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	10.9	Publications
15	SELE	selectin E	10.9	Publications, Pathways & Interactions
16	DHFR	dihydrofolate reductase	10.9	Publications
17	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	10.9	Publications
18	GYPA	glycophorin A (MNS blood group)	10.9	Publications, UniProt Related, Pathways & Interactions
19	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	10.9	Publications
20	TGIF1	TGFB-induced factor homeobox 1	10.9	Publications
21	ADAMTSL1	ADAMTS-like 1	10.9	Publications
22	DHPS	deoxyhypusine synthase	10.9	Publications
23	FCGR2B	Fc fragment of IgG, low affinity IIb, receptor (CD32)	10.9	Publications
24	TCN2	transcobalamin II	10.9	Publications
25	CHIT1	chitinase 1 (chitotriosidase)	10.9	Publications
26	IFNAR1	interferon (alpha, beta and omega) receptor 1	10.9	Publications
27	PECAM1	platelet/endothelial cell adhesion molecule 1	10.9	Publications, Pathways & Interactions
28	CCL4	chemokine (C-C motif) ligand 4	10.9	Publications
29	RBP4	retinol binding protein 4, plasma	10.9	Publications
30	CCL5	chemokine (C-C motif) ligand 5	10.9	Publications
31	GSR	glutathione reductase	10.9	Publications
32	THBS1	thrombospondin 1	10.9	Publications, Pathways & Interactions
33	IGHE	immunoglobulin heavy constant epsilon	10.9	Publications
34	IL1A	interleukin 1, alpha	10.9	Publications
35	MB	myoglobin	10.9	Publications
36	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	10.9	Publications, Pathways & Interactions
37	GYPC	glycophorin C (Gerbich blood group)	10.9	Publications, Pathways & Interactions
38	PFBI	Plasmodium falciparum blood infection levels	10.9
39	MA	Migraine with aura, susceptibility to	10.9
40	TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	10.9	Publications
41	GYPB	glycophorin B (MNS blood group)	10.9	Publications, Pathways & Interactions
42	GYPE	glycophorin E (MNS blood group)	10.9	Publications
43	TLR9	toll-like receptor 9	10.9	Publications, Pathways & Interactions
44	FABP3	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	10.9	Publications
45	MT-CYB	mitochondrially encoded cytochrome b	10.9	Publications
46	TPI1	triosephosphate isomerase 1	10.9	Publications
47	ABO	ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)	10.9	Publications
48	CISH	cytokine inducible SH2-containing protein	10.9	UniProt Related
49	HBB	hemoglobin, beta	10.9	Publications, Pathways & Interactions
50	CNTF	ciliary neurotrophic factor	10.9	Publications

Pathways related to malaria according to GeneDecks:

(show top 50)    (show all 171)

id	Pathway	Score	Top Affiliating Genes
1	Metabolic pathways20	71.3	PIGA, PIGL, PIGQ, PIGO, PIGW, PIGC
2	Spliceosome20	28.3	NCBP2, SF3A1, SF3A2, SF3A3, SF3B1, SF3B14
3	Ribosome20	27.9	UBA52, MRPL13, FAU, RSL24D1, RPS6, RPS3A
4	CFTR translational fidelity (class I mutations)41	26.1	UBA52, FAU, RPS6, RPS3A, RPL27A, RPS21
5	Phagosome20	25.9	PIK3C3, SEC61A1, SEC61A2, SEC61G, VAMP3, RAB5B
6	Protein processing in endoplasmic reticulum20	25.0	RBX1, SEC24B, SEC24C, SEC61A1, SEC61A2, SEC24D
7	Purine metabolism20	25.0	PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A
8	Tuberculosis20	24.7	PIK3C3, RFX5, MYD88, RAB5B, RAB5C, RAB5A
9	Metabolism of mRNA38	23.7	FAU, RPS6, RPS3A, RPS21, RPS26, RPS12
10	SOCS Pathway36	22.6	RBX1, BMP6, CISH, UBE2A, UBE2B, CD2
11	Transcription Ligand-Dependent Transcription of Retinoid-Target genes10	22.0	RBBP7, RBBP4, SAP18, KAT2B, CDK8, CDK7
12	Ubiquitin-Proteasome Dependent Proteolysis36	22.0	USP11, USP13, USP15, USP18, USP21, USP3
13	Transcription_Ligand-Dependent Transcription of Retinoid-Target genes41	22.0	RBBP7, RBBP4, SAP18, KAT2B, CDK8, CDK7
14	Rheumatoid arthritis20	21.8	VEGFA, ATP6V1B1, ATP6V0D1, ATP6V1C2, ATP6V0A4, ATP6V1E2
15	Endocytosis20	21.6	PIP5KL1, VTA1, VPS45, RAB11B, RAB22A, RAB31
16	Gene Expression38	21.6	CNOT1, CNOT2, CNOT3, CNOT4, CNOT6, CNOT6L
17	DNA Repair Mechanisms36	21.4	PCNA, RAD51, RAD50, RAD23B, LIG1, XAB2
18	Malaria20	21.2	LRP1, SELE, SELP, VCAM1, MYD88, SDC1
19	ATP/ITP metabolism41	21.2	ITPA, ENTPD3, ENTPD1, ENTPD2, AMPD1, AMPD2
20	Translational Control3	21.1	ZNF259, PDCD4, CNOT2, PCBP1, LPIN1, CLK3
21	RAR-Gamma-RXR-Alpha Degradation36	21.1	LIF, UBB, UBE3A, UBC, CD2, CDK7
22	RNA transport20	21.1	NCBP2, RBM8A, SENP2, SEC13, SEH1L, RAN
23	Transport_Clathrin-coated vesicle cycle41	21.1	PIK3C3, VPS45, SEC24B, SEC24C, SEC24D, SEC31B
24	ATP/ITP metabolism10	21.0	ITPA, ENTPD3, ENTPD1, ENTPD2, AMPD1, AMPD2
25	Pyrimidine metabolism20	20.5	CMPK1, UMPS, ITPA, ENTPD3, ENTPD8, ENTPD1
26	Protein Stability3	20.2	PIAS4, RECK, REN, RBX1, SENP3, VCP
27	Cell cycle Spindle assembly and chromosome separation10	20.0	NDC80, KIF22, KIF11, RAN, UBA52, UBB
28	Immune response Antigen presentation by MHC class I10	19.9	SEC61A1, SEC61A2, SEC61G, B2M, CD8A, HSP90AA1
29	Cell cycle_Spindle assembly and chromosome separation41	19.9	NDC80, KIF22, KIF11, UBA52, UBB, UBC
30	Metabolism of RNA38	19.9	PABPC1, RPL27A, RPL3, RPL17, RPL18, RPL35
31	Immune response_Antigen presentation by MHC class I41	19.8	SEC61A1, SEC61A2, SEC61G, B2M, CD8A, HSP90AA1
32	Regulation of degradation of deltaF508 CFTR in CF41	19.7	SEC61A1, SEC61A2, SEC61G, VCP, UFD1L, UBA1
33	SMAD Signaling Network36	19.6	BMP6, RAB5B, RAN, RAB5C, RAB5A, UBE3A
34	Processing of Capped Intron-Containing Pre-mRNA38	19.5	SF3A1, SF3A2, SF3A3, SF3B1, SF3B14, SF3B2
35	Remodeling of Adherens Junctions36	19.5	VCL, RAB11B, RAB5B, RAB5C, RAB5A, RAB11A
36	Clathrin-dependent protein traffic10	19.1	SEC24B, SEC24C, SEC24D, SEC31B, SEC13, SEC24A
37	Cytoplasmic microtubules10	18.8	MYO5A, MAPT, MARK1, MARK2, MARK3, MARK4
38	RNA degradation20	18.6	CNOT1, CNOT2, CNOT3, CNOT4, CNOT6, CNOT6L
39	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway41	18.4	UBA1, UBE2G1, HSPA14, HSPA5, HSPA4, HSPA8
40	wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)41	18.0	SEC24B, SEC24C, SEC24D, SEC31B, SEC13, SEC24A
41	Vibrio cholerae infection20	18.0	SEC61A1, SEC61A2, SEC61G, KDELR1, KDELR2, KDELR3
42	Proteasome20	17.9	IFNG, PSMA1, PSMA2, PSMA4, PSMA6, PSMA7
43	Regulation of CFTR activity (norm and CF)41	17.9	ANXA5, GNAS, GNB2L1, TUBA1A, TUBA1B, TUBA1C
44	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway10	17.8	UBA1, UBE2G1, HSPA14, HSPA5, HSPA4, HSPA8
45	SREBP Proteolysis36	17.2	SEC24B, SEC24C, SEC24D, SEC24A, SEC23A, SEC23B
46	Parkinsons Disease Pathway36	16.9	PARK7, UCHL1, UBB, UBC, HSPA4, TUBA8
47	Regulation of degradation of wt-CFTR41	16.7	SEC61A1, SEC61A2, SEC61G, VCP, UFD1L, UBA1
48	G2-M Phase Transition36	16.3	YWHAB, YWHAG, YWHAH, YWHAQ, YWHAZ, CDC25C
49	Chks in Checkpoint Regulation36	15.7	PCNA, RAD50, MRE11A, CDC25C, TLK1, TLK2
50	wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)41	15.3	MYO5B, RAB11A, GNB2L1, TUBA1A, TUBA1B, TUBA1C

Compounds related to malaria according to GeneDecks:

(show top 50)    (show all 397)

id	Compound	Score	Top Affiliating Genes
1	atp32	68.4	PIM1, RFC1, RFC2, RFC4, RFK, NCL
2	cysteine32	46.4	LRP1, COCH, PDE3A, RECK, PCNA, GCK
3	nitric oxide32 9 18 9	48.4	KLF4, PDE2A, PDE3A, PDE3B, PDE4A, REN
4	oxygen32 18	46.2	KITLG, GCK, GCH1, RBP4, SETD2, SERPINA1
5	alanine32	44.6	PIM1, RFC1, PDE2A, PDE3A, CNTF, WARS
6	dexamethasone32 42 34 9 9	48.4	LRP1, PDE4A, REN, KITLG, VWF, PCNA
7	creatinine32	42.4	REN, KITLG, VWF, PCNA, GCK, RBP4
8	superoxide32 18	41.3	PDE2A, PDE3B, PDE4A, CNTF, KITLG, SFN
9	lactate32	40.2	RECK, KITLG, VWF, PCNA, GCK, RBP4
10	cycloheximide32	39.5	PDE4A, CNTF, KITLG, SELE, SETD2, VEGFA
11	magnesium32 9 18 9	41.4	RFK, PDE4A, RECQL, CNOT6, GCK, RBP4
12	adenylate32	37.6	NCL, PDE3A, PDE3B, PDE4A, CNTF, KITLG
13	iron32 18	36.3	RECK, KITLG, RBP4, SETD2, SERPINA1, SERPINA3
14	glutamate32	34.7	PCNA, GCK, VAMP2, BMP6, KDR, SDHB
15	estrogen32	32.6	PIAS1, NCL, VWF, PCNA, GCH1, RBP4
16	glutamine32	31.7	PDE4A, VWF, SF1, PCNA, GCK, VCL
17	glucose32	31.3	PDE4A, CNTF, GCH1, SETD2, SEPP1, LPIN1
18	actinomycin d32	30.9	NCL, PDE4A, CNTF, KITLG, SELE, SETD2
19	genistein32 9 18 9	33.7	CNTF, KITLG, PCNA, SELE, SELP, SETD2
20	cisplatin32 34 9 9	33.0	REV3L, KITLG, PCNA, GCLC, SETD2, VEGFA
21	aspartate32	29.1	PCNA, PCMT1, RBP4, SELP, BMP6, KHSRP
22	fibrinogen32	28.2	RECK, VWF, SELE, SELP, SERPINC1, SERPINA1
23	histamine32 18	29.0	PDE3B, PDE4A, CNTF, KITLG, VWF, PCNA
24	heparin32 9 18 9	30.7	LRP1, NCL, RECK, KITLG, VWF, SERPINA1
25	glyceraldehyde 3-phosphate32	27.6	GCK, SETD2, RAB2A, RARS, UNG, SDHA
26	doxorubicin32 34 9 9	29.0	RECK, KITLG, SELE, SETD2, VEGFA, BMP6
27	indomethacin32 9 9	26.6	PDE4A, REN, PCNA, BMP6, KDR, B2M
28	ascorbic acid32 18	24.5	CNTF, PCNA, GCH1, RBP4, SETD2, LIF
29	herbimycin a32 42	23.7	KITLG, SELE, VCAM1, BMP6, CDK6, CD36
30	endotoxin32	21.8	RECK, MYD88, LIF, CHKB, SAA1, CD40
31	simvastatin32 34 42 9 18 9	25.7	KITLG, VWF, RBP4, SELE, SELP, VEGFA
32	chloroquine32 34 9 9	23.1	SERPINC1, BMP6, BACE1, MTM1, B2M, FTL
33	alpha tocopherol32	19.9	RBP4, SETX, SEC14L2, VCAM1, LIF, SCARB1
34	il 1032	19.7	BMP6, LIF, CD8A, CD40, IL10, IL12B
35	histidine32	18.8	PDE3B, PDE4A, KITLG, BPGM, RAD51, KHDRBS1
36	n acetylcysteine32	18.2	VWF, PCNA, GCLC, SELE, SELP, SERPINC1
37	sodium nitroprusside32	18.1	PDE2A, PDE4A, REN, VWF, PCNA, BMP6
38	citrate32	16.0	GCK, SELP, SDHB, CHKA, CHKB, MT-CO1
39	cyclophosphamide32 34 9 9	15.2	PIGA, ITGAL, ITGB2, APOH, MBL2, TRB@
40	cyclosporin a32 42	INF	PDE4A, RECK, KITLG, VWF, , SELP
41	serine32	INF	PIM2, PIM3, PIAS1, PIM1, LRP1, NCL
42	threonine32	INF	PIM2, PIM3, , SET, VARS, MYO6
43	Adenosine monophosphate9 18 9	INF	PIM1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C
44	tyrosine32	INF	PIAS4, PIAS1, PIP5KL1, PIM1, LRP1, NCL
45	tacrolimus32 34 9 9	INF	REN, , PCNA, BMP6, SCARB2, CHKB
46	vegf32	INF	LRP1, PDE4A, RECK, REN, CNTF, KITLG
47	h2o232	INF	PDE4A, CNTF, KITLG, VWF, , GCK
48	phosphoric acid32 18	INF	COASY, REV3L, CNOT4, WARS, WARS2, PCYT1A
49	pyrophosphate32 18	INF	COASY, REV3L, CNOT4, WARS, WARS2, PCYT1A
50	Adenosine triphosphate9 18 9	INF	PIM2, PIM3, PIK3C3, PIM1, COASY, RFK

Cellular components related to malaria according to GeneDecks:

(show all 32)

id	Name	GO ID	Score	Top Affiliating Genes
1	nucleus	GO:005634	INF	ZNF207, ZNF259, PIAS2, PIAS3, PIAS4, PIAS1
2	cytosol	GO:005829	137.2	PI4KB, PIK3C3, NDC80, RFK, NCBP2, PDCD11
3	nucleolus	GO:005730	80.5	ZNF622, ZNF593, ZNF207, ZNF259, PIAS4, WDR26
4	mitochondrion	GO:005739	63.7	RFK, KIF1B, RDBP, PCBP3, GCK, GCSH
5	nucleoplasm	GO:005654	58.4	PIAS1, RFC1, RFC2, RFC3, RFC4, RFC5
6	endoplasmic reticulum membrane	GO:005789	40.6	PIGG, PIGA, PIGL, PIGQ, PIGO, PIGW
7	extracellular space	GO:005615	37.9	REN, CNTF, KITLG, SFN, PCSK6, RBP4
8	Golgi apparatus	GO:005794	36.0	ZNF622, LRBA, PDE2A, PDE3B, KIF1C, VPS45
9	endoplasmic reticulum	GO:005783	34.9	PIGG, PIGL, LRBA, PDE2A, PDE3B, KIF1C
10	microtubule	GO:005874	28.0	KIF2B, KIF1A, KIF1B, KIF13A, KIF22, KIF24
11	perinuclear region of cytoplasm	GO:048471	27.5	PI4KB, PDE2A, PDE4A, PDE4B, SEC24B, SEC24C
12	mitochondrial inner membrane	GO:005743	26.0	CLPX, UQCRC1, UQCRFS1, SDHA, SDHB, SCO1
13	mitochondrial matrix	GO:005759	25.7	PDE2A, WARS2, NARS2, RAD51, CLPP, PARS2
14	centrosome	GO:005813	23.8	KIF13A, KIF2A, RBM39, NAA11, BRSK1, RAB6C
15	ribonucleoprotein complex	GO:030529	20.9	NCL, PCBP1, PCBP2, PCBP4, PCBP3, NAA38
16	nuclear speck	GO:016607	20.8	PIAS2, PIAS1, SF3A3, SF3B1, RBM25, RBM39
17	catalytic step 2 spliceosome	GO:071013	20.4	SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3
18	cytosolic large ribosomal subunit	GO:022625	20.2	UBA52, RPL27A, RPL3, RPL17, RPL18, RPL35
19	spliceosomal complex	GO:005681	19.8	SF1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2
20	endosome membrane	GO:010008	18.7	KIF13A, VTA1, VPS26A, VPS29, VPS45, VPS53
21	external side of plasma membrane	GO:009897	18.6	VWF, SELP, VCAM1, LILRB1, CLPTM1, KDR
22	proteasome complex	GO:000502	18.5	VCP, RAD23A, USP14, UCHL5, UBE3A, UBXN1
23	ribosome	GO:005840	18.1	SF1, GCN1L1, UBA52, QTRT1, MRPL24, MRPL2
24	cytosolic small ribosomal subunit	GO:022627	17.6	FAU, DDX3X, RPS6, RPS3A, RPS21, RPS27
25	melanosome	GO:042470	16.9	NAP1L1, RAB2A, RAB5B, RAB35, RAN, RAB27A
26	small nuclear ribonucleoprotein complex	GO:030532	13.4	SF3A2, SF3B3, SNRPN, SNRPD1, SNRPF, SNRPD2
27	small ribosomal subunit	GO:015935	13.3	MRPS12, FAU, GNB2L1, RPS6, RPS21, RPS26
28	proteasome core complex	GO:005839	13.2	PSMA6, PSMB2, PSMB4, PSMB5, PSMB7, PSMB9
29	U12-type spliceosomal complex	GO:005689	13.2	SF3B1, SF3B14, SF3B2, SF3B3, SF3B4, SF3B5
30	COPI vesicle coat	GO:030126	12.4	SCYL1, ARCN1, AP4E1, COPZ2, COPA, COPB1
31	DNA-directed RNA polymerase II, core complex	GO:005665	12.2	POLR2A, POLR2B, POLR2E, POLR2F, POLR2I, POLR2J
32	cytoplasm	GO:005737	INF	ZNF622, ZNF259, PIAS3, PIAS4, PIM3, PIP5KL1

Biological processes related to malaria according to GeneDecks:

(show top 50)    (show all 119)

id	Name	GO ID	Score	Top Affiliating Genes
1	gene expression	GO:010467	73.2	NCBP2, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6
2	small molecule metabolic process	GO:044281	69.6	PI4KB, PIK3C3, COASY, RFK, PCYT1A, PCYT1B
3	cellular protein metabolic process	GO:044267	50.8	PIGG, PIGA, PIGL, PIGQ, PIGO, PIGW
4	RNA metabolic process	GO:016070	44.4	NCBP2, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6
5	viral reproduction	GO:016032	44.3	NCBP2, RDBP, RBX1, SEH1L, RANBP1, RAN
6	mRNA metabolic process	GO:016071	42.6	NCBP2, CNOT1, CNOT2, CNOT3, CNOT4, CNOT6
7	translation	GO:006412	41.8	WARS, GCN1L1, SEC11A, SEC11C, SEC61G, NACA
8	mitotic cell cycle	GO:000278	32.5	NDC80, RFC1, RFC2, RFC3, RFC4, RFC5
9	nuclear mRNA splicing, via spliceosome	GO:000398	31.2	NCBP2, SF1, SF3A1, SF3A2, SF3A3, SF3B1
10	translational initiation	GO:006413	31.1	PABPC1, UBA52, FAU, RPS6, RPS3A, RPL27A
11	virus-host interaction	GO:019048	29.6	KIN, SF3B2, RBX1, NACA, VCAM1, LMBRD1
12	protein folding	GO:006457	29.5	SEC63, VBP1, UXT, CLPX, MPDU1, FKBP4
13	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	GO:000184	28.9	NCBP2, RBM8A, PARN, PABPC1, UPF1, UBA52
14	SRP-dependent cotranslational protein targeting to membrane	GO:006614	28.5	SEC11A, SEC11C, SEC61G, UBA52, FAU, DDOST
15	translational elongation	GO:006414	27.9	VARS, UBA52, FAU, TUFM, RPS6, RPS3A
16	viral infectious cycle	GO:019058	27.6	RAN, PABPN1, UBA52, XPO1, FAU, RPS6
17	protein phosphorylation	GO:006468	27.0	PIM2, PIM3, PIM1, BRSK1, BRSK2, CLK2
18	translational termination	GO:006415	26.8	UBA52, GSPT2, FAU, ETF1, RPS6, RPS3A
19	viral transcription	GO:019083	26.4	UBA52, FAU, RPS6, RPS3A, RPL27A, RPS21
20	DNA repair	GO:006281	25.2	RFC1, RFC2, RFC3, RFC4, RFC5, RECQL
21	cellular nitrogen compound metabolic process	GO:034641	24.5	GCLC, BCKDHA, BCKDHB, AZIN1, ASNS, ARG2
22	intracellular protein transport	GO:006886	23.3	KIF13A, VPS16, VPS18, VPS45, SEC24B, SEC24C
23	S phase of mitotic cell cycle	GO:000084	23.2	RFC1, RFC2, RFC3, RFC4, RFC5, PCNA
24	G1/S transition of mitotic cell cycle	GO:000082	22.8	PIM2, PCNA, UBA52, UBB, UBC, CDK6
25	rRNA processing	GO:006364	22.6	PDCD11, UTP11L, UTP23, PA2G4, SBDS, FTSJ1
26	antigen processing and presentation of peptide antigen via MHC class I	GO:002474	22.6	SEC24B, SEC24C, SEC61A1, SEC61A2, SEC24D, SEC13
27	cell cycle checkpoint	GO:000075	21.8	RFC2, RFC3, RFC4, RFC5, UBA52, UBB
28	antigen processing and presentation of exogenous peptide antigen via MHC class I	GO:042590	20.9	SEC61A1, SEC61A2, SEC61G, UBA52, UBB, UBC
29	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	GO:002479	20.8	SEC61A1, SEC61A2, SEC61G, UBA52, UBB, UBC
30	M/G1 transition of mitotic cell cycle	GO:000216	20.6	UBA52, UBB, MCM2, MCM3, MCM4, MCM5
31	ubiquitin-dependent protein catabolic process	GO:006511	20.3	USP11, USP13, USP15, USP18, USP21, USP24
32	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	GO:031145	19.3	UBA52, UBB, UBC, UBE2D1, AURKA, AURKB
33	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051437	19.0	UBA52, UBB, UBC, UBE2D1, FZR1, CDC20
34	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051439	19.0	UBA52, UBB, UBC, UBE2D1, FZR1, CDC20
35	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	18.6	KIF2B, KIF18A, KIF2C, KIF2A, KIF22, KIF11
36	cellular membrane organization	GO:016044	18.5	VTA1, SEC24B, SEC24C, SEC24D, SEC13, SEC24A
37	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	GO:051436	18.4	UBA52, UBB, UBC, UBE2D1, FZR1, CDC20
38	regulation of cellular amino acid metabolic process	GO:006521	18.3	AZIN1, INS, ODC1, PSMA1, PSMA2, PSMA4
39	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:006977	18.2	UBA52, UBB, UBC, RPS27A, PSMA1, PSMA2
40	microtubule-based movement	GO:007018	18.1	KIF2B, KIF18A, KIF1B, KIF2C, KIF2A, KIF22
41	cellular iron ion homeostasis	GO:006879	16.9	ATP6V1B1, ATP6V0D1, ATP6V1C2, ATP6V0A4, ATP6V1E2, ATP6V1D
42	nucleotide-excision repair	GO:006289	16.9	RFC1, RFC2, RFC3, RFC4, RFC5, PCNA
43	tRNA aminoacylation for protein translation	GO:006418	16.5	WARS, WARS2, NARS2, VARS, VARS2, RARS
44	glycolysis	GO:006096	16.4	GCK, BPGM, LDHA, LDHAL6A, LDHAL6B, LDHB
45	transcription-coupled nucleotide-excision repair	GO:006283	15.9	RFC1, RFC2, RFC3, RFC4, RFC5, PCNA
46	ATP hydrolysis coupled proton transport	GO:015991	15.5	ATP6V1B1, ATP6V0D1, ATP1A2, ATP4A, ATP6V1C2, ATP6V0A4
47	de novo posttranslational protein folding	GO:051084	15.4	VBP1, CCT7, CCT4, CCT3, CCT6A, CCT2
48	protein polyubiquitination	GO:000209	INF	UBA52, UBB, UBE2A, UBE2D3, UBE2V2, UBC
49	RNA splicing	GO:008380	INF	NCBP2, SF3A1, SF3A2, SF3A3, SF3B1, SF3B14
50	mRNA processing	GO:006397	INF	WDR33, NCBP2, PDCD11, KIN, SF3A1, SF3A2

Molecular functions related to malaria according to GeneDecks:

(show all 49)

id	Name	GO ID	Score	Top Affiliating Genes
1	ATP binding	GO:005524	99.0	PIM2, PIM3, PIP5KL1, PI4KB, PIK3C3, PIM1
2	metal ion binding	GO:046872	52.7	WDFY3, RFK, PDE10A, PDE11A, PDE1A, PDE1B
3	GTP binding	GO:005525	38.8	GCH1, SEPHS1, BMS1, RAB11B, RAB22A, RAB2A
4	nucleotide binding	GO:000166	33.1	RFC3, NCBP2, NCBP2L, NCL, REV3L, CNOT4
5	structural constituent of ribosome	GO:003735	29.7	UBA52, MRPL3, MRPL15, MRPL24, MRPL28, MRPL2
6	protein homodimerization activity	GO:042803	29.6	PDE2A, VWF, GCH1, VEGFA, VAPB, LILRB1
7	GTPase activity	GO:003924	27.8	BMS1, RAB11B, RAB22A, RAB2A, RAB6A, RAB1A
8	protein serine/threonine kinase activity	GO:004674	26.0	PIM2, PIM3, PIM1, BRSK1, BRSK2, BMP2K
9	unfolded protein binding	GO:051082	24.5	SEC63, NAP1L4, VBP1, UXT, CLPX, GRPEL1
10	protein kinase activity	GO:004672	20.7	PIK3C3, SCYL2, AURKA, AURKC, MOK, CDK5
11	magnesium ion binding	GO:000287	20.4	GCK, GCLC, BRSK1, BRSK2, PAPOLA, MTPAP
12	enzyme binding	GO:019899	18.8	PIAS3, PIAS1, RFC5, PCBP2, GCSH, VAPB
13	translation initiation factor activity	GO:003743	18.0	BRF1, MTIF2, GTF2B, LOC255308, TRMT6, EIF1B
14	heat shock protein binding	GO:031072	17.9	SEC63, FKBP4, FKBP5, FAF1, HSCB, PPID
15	ubiquitin protein ligase binding	GO:031625	17.1	PIAS2, PIAS4, PCBP2, RBX1, USP13, USP2
16	protein transporter activity	GO:008565	16.7	VPS26A, SEC61G, RANBP17, XPO1, ARFGAP3, IPO5
17	ATPase activity	GO:016887	16.7	RFC3, KIF1B, VCP, BLM, CLPX, MSH2
18	ATP-dependent helicase activity	GO:008026	16.6	BLM, CETN2, CETN1, DDX1, DDX10, DDX17
19	ubiquitin thiolesterase activity	GO:004221	16.6	USP11, USP13, USP15, USP18, USP21, USP24
20	ARF GTPase activator activity	GO:008060	15.7	ASAP1, ASAP2, ASAP3, ARFGAP3, ARFGAP2, ARFGAP1
21	microtubule motor activity	GO:003777	15.3	KIF2B, KIF1A, KIF1B, KIF13A, KIF2C, KIF2A
22	DNA-directed RNA polymerase activity	GO:003899	14.9	POLR1B, POLR1C, POLR2A, POLR2B, POLR2E, POLR2F
23	tRNA binding	GO:000049	14.8	SEPSECS, RARS, YARS2, KARS, METTL1, FDXACB1
24	mRNA binding	GO:003729	14.8	RBM25, RBM8A, PARK7, CELF1, CELF3, CELF4
25	threonine-type endopeptidase activity	GO:004298	14.6	PSMA1, PSMA2, PSMA4, PSMA6, PSMA7, PSMB2
26	helicase activity	GO:004386	14.5	RAD54L2, RAD54L, BLM, UPF1, ATRX, MCM2
27	cysteine-type peptidase activity	GO:008234	14.5	SENP7, SENP5, USP21, USP24, USP32, USP43
28	chaperone binding	GO:051087	14.5	VWF, ATP1A1, GRPEL1, GRPEL2, ALB, HSPA5
29	cysteine-type endopeptidase activity	GO:004197	14.4	PIGK, USP11, USP13, USP15, USP34, USP6
30	ubiquitin-specific protease activity	GO:004843	14.4	SENP3, USP11, USP13, USP15, USP18, USP21
31	single-stranded DNA binding	GO:003697	14.3	PCBP1, RBMS1, RAD51, RAD23A, RAD23B, BLM
32	ribosome binding	GO:043022	14.3	SEC61A1, NAA10, NAA15, NAA16, SBDS, HSPA5
33	methyltransferase activity	GO:008168	14.2	WBSCR22, LCMT2, FTSJ1, FTSJ3, METTL8, METTL2A
34	peptidyl-prolyl cis-trans isomerase activity	GO:003755	14.1	CWC27, PPIA, PPIE, PPWD1, PPIB, PPIC
35	rRNA binding	GO:019843	14.0	SBDS, MRPL20, IMP3, ERAL1, RPS9, RPS18
36	nucleoside-triphosphatase activity	GO:017111	13.9	RFC2, RFC4, RFC5, CLPB, BCS1L, CHTF18
37	protein serine/threonine phosphatase activity	GO:004722	13.6	CDKN3, ILKAP, CYCS, CTDNEP1, PPP4C, PPP3CA
38	4 iron, 4 sulfur cluster binding	GO:051539	13.6	REV3L, LIAS, SDHB, MUTYH, CDKAL1, IREB2
39	protein disulfide oxidoreductase activity	GO:015035	13.6	P4HB, GLRX, GLRX2, GLRX3, GLRX5, TXN
40	translation elongation factor activity	GO:003746	13.6	TUFM, EIF5AL1, EIF5A, EIF5A2, GFM1, GFM2
41	translation factor activity, nucleic acid binding	GO:008135	13.6	GCN1L1, MTIF2, GTF2H2, GTF2H3, ABCF1, EIF2B3
42	ATP-dependent RNA helicase activity	GO:004004	13.5	UPF1, SUPV3L1, DDX18, DDX21, DDX23, DDX24
43	hydrogen ion transmembrane transporter activity	GO:015078	13.3	ATP6V1B1, ATP6V0D1, ATP6V0A4, ATP6V1B2, ATP6V0D2, ATP6V0A2
44	ATP-dependent DNA helicase activity	GO:004003	13.0	RECQL, RAD50, BLM, CHD1, CHD2, MRE11A
45	ADP binding	GO:043531	12.9	GCK, GCLC, MYO6, P2RY1, MSH2, MSH6
46	tau-protein kinase activity	GO:050321	12.5	BRSK1, BRSK2, CDK5, GSK3A, GSK3B, MARK1
47	3,5-cyclic-AMP phosphodiesterase activity	GO:004115	11.3	PDE1B, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C
48	RNA binding	GO:003723	INF	LRRC47, NCBP2, NCL, PDCD11, PDCD4, CNOT4
49	protein binding	GO:005515	INF	ZNF622, PIGA, PIAS2, PIAS3, PIAS4, PIM3