MCID: MLR004
MIFTS: 66

Malaria malady

Summaries for Malaria

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Malaria is a serious disease caused by a parasite. you get it when an infected mosquito bites you. malaria is a major cause of death worldwide, but it is almost wiped out in the united states. the disease is mostly a problem in developing countries with warm climates. if you travel to these countries, you are at risk. there are four different types of malaria caused by four related parasites. the most deadly type occurs in africa south of the sahara desert. malaria symptoms include chills, flu-like symptoms, fever, vomiting, diarrhea, and jaundice. a blood test can diagnose it. it can be life-threatening. however, you can treat malaria with drugs. the type of drug depends on which kind of malaria you have and where you were infected. malaria can be prevented. when traveling to malaria-prone regions see your doctor for medicines that protect you wear insect repellent with deet cover up sleep under mosquito netting centers for disease control and prevention

MalaCards: Malaria, also known as induced malaria, is related to plasmodium falciparum malaria and cerebral malaria. An important gene associated with Malaria is NOS2 (nitric oxide synthase 2, inducible), and among its related pathways are Malaria and Tuberculosis. The drugs hydroxychloroquine and hydroxychloroquine sulfate and the compounds nitric oxide and tyrosine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

NIH Rare Diseases:43 Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. people who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. in general, malaria is a curable disease if diagnosed and treated promptly and correctly. treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired. last updated: 5/12/2011

CDC:3 Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 219 million cases of malaria occurred worldwide and 660,000 people died, most (91%) in the African Region.

Wikipedia:64 Malaria is a mosquito-borne infectious disease of humans and other animals caused by parasitic... more...

Description from OMIM:47 611162

Aliases & Classifications for Malaria

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
See all sources

Aliases & Descriptions:

malaria 8 43 47 10 45 34 61
induced malaria 8 61


External Ids:

Disease Ontology8 DOID:12365
MeSH35 D008288
ICD9CM27 084.6, 084
NCIt40 C34797

Related Diseases for Malaria

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Malaria family:

malaria, severe

Diseases related to Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 320)
idRelated DiseaseScoreTop Affiliating Genes
1plasmodium falciparum malaria31.9IFNG, ICAM1, G6PD, CR1, CD36, SELE
2cerebral malaria31.8ICAM1, CD36
3plasmodium vivax malaria31.7G6PD, DHFR, DARC
4thrombocytopenia30.8HP, FCGR2B
5splenomegaly30.6HP
6thalassemia30.5G6PD, HBB, SLC4A1
7alpha thalassemia30.4G6PD, HBB
8blackwater fever30.4G6PD
9sepsis30.4SELE, CR1, MIF, NOS2, IL10, CISH
10pancytopenia30.3DHFR, HP
11deficiency anemia30.2SLC4A1, DHFR, HP, HBB, MIF, CR1
12tuberculosis30.2HP, CR1, HBB, MIF, IFNG, DHFR
13hepatitis c30.2CISH, IL10, CR1, IFNG, HP
14chagas disease30.2DHFR
15visceral leishmaniasis30.2IL10, IFNG
16sickle cell disease30.2SELE, HP, HBB, G6PD
17hereditary elliptocytosis30.2SLC4A1, GYPC, G6PD
18systemic lupus erythematosus30.1MIF, SELE, FCGR2B, IL10, CR1, IFNG
19adult respiratory distress syndrome30.1NOS2, MIF, CR1, SELE
20methemoglobinemia30.1G6PD, HP
21asthma29.9NOS2, IL10, IFNG, ICAM1, CR1, SELE
22burkitt's lymphoma29.9CR1, CISH, HBB, ICAM1, DHFR, IL10
23sickle cell anemia29.9HBB, G6PD, HP
24viral hepatitis29.9G6PD, CISH
25acute pancreatitis29.9IL10, MIF
26vaccinia29.9DARC
27urticaria29.9SELE
28atopic dermatitis29.7IL10, MIF, ICAM1, IFNG, SELE
29autoimmune hemolytic anemia29.7HP, G6PD, GYPA
30insulin resistance29.7SELE, CISH, MIF
31atopy29.7IL10, IFNG, MIF
32hepatitis b29.7IL10, CR1, IFNG
33alzheimer's disease29.7CR1, NOS2, MIF
34acquired immunodeficiency syndrome29.7DHFR
35favism29.7HP, G6PD
36toxoplasmosis29.7DHFR
37malaria, severe11.0
38plasmodium ovale malaria10.6
39mixed malaria10.5
40plasmodium malariae malaria10.5
41malaria, mild10.4
42babesiosis10.4
43typhoid fever10.3
44trypanosomiasis10.3
45ataxia10.3
46sleeping sickness10.2
47acute disseminated encephalomyelitis10.2
48acalculous cholecystitis10.2
49splenic infarction10.2
50pyruvate kinase deficiency10.2

Graphical network of the top 20 diseases related to Malaria:



Diseases related to malaria

Clinical Features for Malaria

Sources:
47OMIM
See all sources

Clinical features from OMIM:

611162

Drugs & Therapeutics for Malaria

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malaria

Drug clinical trials:

Search ClinicalTrials for Malaria

Search NIH Clinical Center for Malaria

Search CenterWatch for Malaria

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Malaria

Anatomical Context for Malaria

Animal Models for Malaria or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Malaria

Sources:
51PubMed
See all sources

Articles related to Malaria:

(show top 50)    (show all 3206)
idTitleAuthorsYear
1
Influence of deforestation, logging, and fire on malaria in the brazilian Amazon. (24404206)
2014
2
Malaria: Resistance nailed. (24352240)
2014
3
Rabies, tetanus, leprosy, and malaria. (24365433)
2014
4
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
5
The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria. (24062941)
2013
6
NIAID meeting report: Improving malaria vaccine strategies through the application of immunological principles. (24060568)
2013
7
Molecular evidence for historical presence of knock-down resistance in Anopheles albimanus, a key malaria vector in Latin America. (24330978)
2013
8
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
9
Therapeutic efficacy of artesunate in the treatment of uncomplicated Plasmodium falciparum malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China-Myanmar border. (22898135)
2012
10
Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children. (21814839)
2012
11
Status of Plasmodium vivax malaria in the Republic of Korea, 2008-2009: decrease followed by resurgence. (22560604)
2012
12
Relationship between inflammatory mediator patterns and anemia in HIV-1 positive and exposed children with Plasmodium falciparum malaria. (22570198)
2012
13
Plasmodium berghei ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model. (21044627)
2011
14
Symmetrical peripheral gangrene and neurological manifestations in Plasmodium falciparum malaria. (22315752)
2011
15
Co-infection of Malaria and Crimean-Congo Hemorrhagic Fever. (22347306)
2011
16
Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria. (21813042)
2011
17
IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks. (21224257)
2011
18
Adherence to Plasmodium vivax malaria treatment in the Brazilian Amazon Region. (22165853)
2011
19
Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis. (22049029)
2011
20
Association of ADAMTS13 polymorphism with cerebral malaria. (22168261)
2011
21
Frequencies of some human genetic markers and their association with Plasmodium falciparum malaria in the Niger Delta, Nigeria. (20231768)
2010
22
Quantitation of CD36 (platelet glycoprotein IV) expression on platelets and monocytes by flow cytometry: application to the study of Plasmodium falciparum malaria. (18671254)
2009
23
Coagulation status and platelet functions in children with severe falciparum malaria and their correlation of outcome. (19401406)
2009
24
Acute lung injury and other serious complications of Plasmodium vivax malaria. (18582837)
2008
25
Towards a species-selective acetylcholinesterase inhibitor to control the mosquito vector of malaria, Anopheles gambiae. (18554580)
2008
26
Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. (18644885)
2008
27
Louse-borne relapsing fever and malaria co-infection in Ethiopia. (17540107)
2007
28
Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus. (17312006)
2007
29
Epilepsy as a consequence of cerebral malaria in area in which malaria is endemic in Mali, West Africa. (16686652)
2006
30
Modeling the relationship between the population prevalence of Plasmodium falciparum malaria and anemia. (16931819)
2006
31
Activation of calpains, calpastatin and spectrin cleavage in the brain during the pathology of fatal murine cerebral malaria. (16236382)
2006
32
Changes in optic nerve head blood flow in children with cerebral malaria and acute papilloedema. (17043298)
2006
33
Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice. (16362897)
2006
34
Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit. (15712076)
2005
35
Cerebral malaria and heme oxygenase-1]. (12704843)
2003
36
Correlation of plasma levels of tumor necrosis factor, interleukin-6 and nitric oxide with the severity of human malaria. (12214930)
2002
37
IgE elevation and anti-plasmodium falciparum IgE antibodies: association of high level with malaria resistance. (12041541)
2001
38
Tumor necrosis factor-alpha promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort Project IX. (11668577)
2001
39
Absence of association between the allele coding methionine at position 29 in the N-terminal domain of ICAM-1 (ICAM-1(Kilifi)) and severe malaria in the northwest of Thailand. (11544402)
2001
40
Lesion associated expression of urokinase-type plasminogen activator receptor (uPAR, CD87) in human cerebral malaria. (11063844)
2000
41
Microvascular hemodynamics and in vivo evidence for the role of intercellular adhesion molecule-1 in the sequestration of infected red blood cells in a mouse model of lethal malaria. (9502610)
1998
42
Baculovirus merozoite surface protein 1 C-terminal recombinant antigens are highly protective in a natural primate model for human Plasmodium vivax malaria. (9529073)
1998
43
Immune stimulation by syphilis and malaria in HIV-2-infected and uninfected villagers in West Africa. (9624734)
1997
44
Plasma macrophage colony-stimulating factor and P-selectin levels in malaria-associated thrombocytopenia. (9157583)
1997
45
Relapsing fever: a differential diagnosis to malaria. (8893411)
1996
46
Malaria, blood glucose, and the role of tumour necrosis factor (TNF) in mice. (8809132)
1996
47
Interleukin-10 inhibits tumor necrosis factor production but not antigen-specific lymphoproliferation in acute Plasmodium falciparum malaria. (7658079)
1995
48
Mechanisms of cytoadhesion of flowing, parasitized red blood cells from Gambian children with falciparum malaria. (7542844)
1995
49
Plasmodium vivax malaria from Mexico--a problem in the United States. (3318139)
1987
50
Activation of latent kala-azar by malaria and relapsing fever. (18891450)
1948

Genetic Variations for Malaria

Expression for genes affiliated with Malaria

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malaria

Search GEO for disease gene expression data for Malaria.

Pathways for genes affiliated with Malaria

Sources:
30KEGG, 12EMD Millipore, 54Reactome, 38NCBI BioSystems Database
See all sources

Compounds for genes affiliated with Malaria

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB, 50PharmGKB
See all sources

Compounds related to Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1nitric oxide45 11 2415.9IL10, NOS2, SLC4A1, HBB, MIF, HP
2tyrosine4513.8DARC, HP, HBB, GYPB, MIF, GYPC
3lipid4513.6GYPA, SLC4A1, G6PD, MIF, GYPC, CISH
4alanine4513.3SELE, DHFR, GYPA, GYPC, MIF, HBB
5lactate4513.1DHFR, HP, MIF, G6PD, ICAM1, SLC4A1
6serine4513.0HBB, FCGR2B, HP, G6PD, SELE, CISH
7h2o24513.0HBB, CD36, HP, DHFR, NOS2, ICAM1
8vegf4513.0IFNG, ICAM1, MIF, CD36, HP, SELE
9sb 20358045 6013.8ICAM1, MIF, IL10, NOS2, SELE, IFNG
10genistein45 29 60 2 11 2417.7ICAM1, SELE, MIF, CD36, FCGR2B, NOS2
11adenylate4512.7NOS2, G6PD, CR1, SELE, HBB, HP
12herbimycin a45 6013.5ICAM1, MIF, CD36, NOS2, IFNG, SELE
13dmso4512.5CR1, CD36, HBB, IL10, SELE, G6PD
14ascorbic acid45 2413.5G6PD, HP, DHFR, NOS2, CD36, ICAM1
15actinomycin d4512.4IFNG, ICAM1, G6PD, HP, NOS2, SELE
16polymyxin b4512.3SELE, IL10, IFNG, CR1, ICAM1
17sialic acid4512.3GYPC, GYPA, GYPB, MIF, SELE
18lactose45 1113.2SELE, G6PD, MIF, HP, DHFR
19thymidine45 2413.1GYPC, FCGR2B, IL10, HBB, MIF, IFNG
20folate4512.1DHFR, SLC4A1, SELE, HP, G6PD
21glyceraldehyde 3-phosphate4512.0HBB, G6PD, SLC4A1, DARC, GYPC
22tuberculin4512.0IL10, HP, MIF, IFNG
23natalizumab45 1113.0FCGR2B, IFNG, ICAM1, IL10
24okt34511.9IL10, ICAM1, SELE, IFNG
25sulfasalazine45 29 50 1114.9G6PD, HP, SELE, ICAM1
268-isoprostane4511.9HP, IL10, SELE, ICAM1
27polyinosinic-polycytidylic acid4511.9SELE, IL10, NOS2, IFNG
28mycophenolate mofetil45 50 1113.9IFNG, IL10, CD36, SELE
29ribavirin45 50 1113.9G6PD, IL10, IFNG, HP
30neopterin4511.8ICAM1, IL10, HP, IFNG
3115-deoxy-delta-12,14-prostaglandin j24511.8IL10, CD36, IFNG, NOS2
32thalidomide45 50 60 1114.7IL10, CD36, MIF, IFNG
33rantes4511.7ICAM1, DARC, IFNG
34chloroquine45 2 50 29 1115.7IL10, G6PD, HP, DHFR
35interferon gamma4511.6IL10, ICAM1, IFNG
36cyclophosphamide45 50 1113.6DHFR, MIF, G6PD
3723-diphosphoglycerate4511.6HP, HBB, G6PD
388 methoxypsoralen4511.6ICAM1, SELE, IL10
39pentamidine45 1112.5IFNG, G6PD, DHFR
40polyethylene glycol4511.5SELE, HP, G6PD, ICAM1
41aspartate4511.5SELE, DHFR, G6PD, HBB
42endotoxin4511.5ICAM1, SELE
43ulinastatin4511.3HP, ICAM1
44pdtc4511.2NOS2, SELE
45adalimumab45 50 1113.2IL10, FCGR2B, IFNG
46cycloheximide4511.2CR1
47estrogen4511.1FCGR2B
48dexamethasone45 50 29 1114.1CISH
49hind iii4511.0CR1, HBB, HP
50pirfenidone45 6011.9CD36

GO Terms for genes affiliated with Malaria

Sources:
16Gene Ontology
See all sources

Cellular components related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588613.3CISH, SELE, SLC4A1, FCGR2B, DARC, CD36
2integral to plasma membraneGO:00588712.7SLC4A1, CD36, GYPB, GYPA, GYPC, NCR3
3extracellular spaceGO:00561512.1IFNG, ICAM1, MIF, HP, IL10, SELE
4cortical cytoskeletonGO:03086311.7GYPC, SLC4A1, NOS2, SELE
5external side of plasma membraneGO:00989711.2IFNG, ICAM1, GYPA, CD36
6haptoglobin-hemoglobin complexGO:03183811.0HP, HBB

Biological processes related to Malaria according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695412.2NCR3, MIF, IL10, DARC, NOS2, SELE
2cellular response to lipopolysaccharideGO:07122212.0NOS2, IL10, CD36, ICAM1, IFNG
3defense response to bacteriumGO:04274211.5NOS2, IL10, HP, IFNG
4negative regulation of growth of symbiont in hostGO:04413011.3IFNG, CD36, IL10
5positive regulation of nitric oxide biosynthetic processGO:04542911.2IFNG, ICAM1, HBB
6positive regulation of MHC class II biosynthetic processGO:04534811.0IL10, IFNG
7positive regulation of killing of cells of other organismGO:05171210.7NOS2, IFNG

Molecular functions related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin bindingGO:03049211.0HP, HBB

Products for genes affiliated with Malaria

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Malaria

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet