MCID: MLR004
MIFTS: 75

Malaria malady

Rare diseases, Infectious diseases categories
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Summaries for Malaria

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MedlinePlus:33 Malaria is a serious disease caused by a parasite. you get it when an infected mosquito bites you. malaria is a major cause of death worldwide, but it is almost wiped out in the united states. the disease is mostly a problem in developing countries with warm climates. if you travel to these countries, you are at risk. there are four different types of malaria caused by four related parasites. the most deadly type occurs in africa south of the sahara desert. malaria symptoms include chills, flu-like symptoms, fever, vomiting, diarrhea, and jaundice. a blood test can diagnose it. it can be life-threatening. however, you can treat malaria with drugs. the type of drug depends on which kind of malaria you have and where you were infected. malaria can be prevented. when traveling to malaria-prone regions see your doctor for medicines that protect you wear insect repellent with deet cover up sleep under mosquito netting centers for disease control and prevention

MalaCards based summary: Malaria, also known as induced malaria, is related to plasmodium falciparum malaria and cerebral malaria. An important gene associated with Malaria is NOS2 (nitric oxide synthase 2, inducible), and among its related pathways are Malaria and Tuberculosis. The drugs hydroxychloroquine and hydroxychloroquine sulfate and the compounds serine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

NIH Rare Diseases:42 Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. people who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. in general, malaria is a curable disease if diagnosed and treated promptly and correctly. treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired. last updated: 5/12/2011

CDC:3 Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 219 million cases of malaria occurred worldwide and 660,000 people died, most (91%) in the African Region.

Wikipedia:65 Malaria is a mosquito-borne infectious disease of humans and other animals caused by parasitic... more...

Description from OMIM:46 611162

Aliases & Classifications for Malaria

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Malaria, Aliases & Descriptions:

Name: Malaria 30 8 42 46 10 44 33 62
 
Induced Malaria 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


External Ids:

Disease Ontology8 DOID:12365
ICD9CM27 084, 084.6
MeSH34 D008288
NCIt39 C34797

Related Diseases for Malaria

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Diseases in the Malaria family:

Malaria, Severe

Diseases related to Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 308)
idRelated DiseaseScoreTop Affiliating Genes
1plasmodium falciparum malaria33.2IL10, HP, CR1, NOS2, CD36, IFNG
2cerebral malaria33.2TNF, G6PD, ICAM1, IFNG, IL10, HP
3plasmodium vivax malaria32.8DARC, G6PD
4thrombocytopenia31.8HP, FCGR2B, FCGR2A
5leishmaniasis31.7IFNG, IL10
6tuberculosis31.6TNF, HBB, IFNG, IL10, HP, CR1
7hemolytic anemia31.5HBB, G6PD, HP, CR1, SLC4A1
8blackwater fever31.5G6PD
9alpha thalassemia31.5G6PD, HBB
10encephalitis31.4DARC, GYPC, NOS2
11deficiency anemia31.4HBB, FCGR2A, G6PD, HP, CR1, SLC4A1
12glomerulonephritis31.3NOS2, CR1, ICAM1, FCGR2A
13pneumonia31.3TNF, GYPA, ICAM1, IL10, CR1
14sepsis31.3TNF, FCGR2A, CISH, IL10, CR1, NOS2
15sickle cell disease31.3HP, G6PD, HBB
16visceral leishmaniasis31.3IFNG, IL10
17hereditary elliptocytosis31.2G6PD, GYPC, SLC4A1
18adult respiratory distress syndrome31.2TNF, CR1, NOS2
19systemic lupus erythematosus31.2CR1, FCGR2A
20methemoglobinemia31.2G6PD, HP
21pre-eclampsia31.2HBB, ICAM1, IL10, HP, NOS2
22burkitt's lymphoma31.1CR1, IL10, ICAM1, CISH, FCGR2B, FCGR2A
23multiple sclerosis31.0TNF, ICAM1, IFNG, IL10, CR1, NOS2
24glucosephosphate dehydrogenase deficiency31.0G6PD, HP
25melanoma31.0TNF, FCGR2A, CISH, GYPC, ICAM1, IFNG
26septic shock30.9NOS2, CR1, IL10, TNF
27atopic dermatitis30.9IL10, IFNG, ICAM1, TNF
28hemoglobinopathy30.9HBB, G6PD, HP
29asthma30.9TNF, CISH, ICAM1, IFNG, IL10, CR1
30autoimmune hemolytic anemia30.9G6PD, GYPA, HP
31hepatitis b30.8CR1, IL10, IFNG
32favism30.8HP, G6PD
33hemoglobinuria30.7G6PD, HP
34leukemia30.7TNF, HBB, CISH, GYPA, ICAM1, IFNG
35beta thalassemia30.5G6PD, HBB
36ischemia30.3SERPINI1, ICAM1, HP, CR1, NOS2
37cerebritis11.2
38atherosclerosis10.9TNF, FCGR2A, G6PD, ICAM1, IL10, HP
39ipex syndrome10.9DARC, TNF, HBB, FCGR2A, GYPC, IFNG
40inflammatory bowel disease10.8DARC, TNF, ICAM1, IFNG, IL10, NOS2
41acute erythroid leukemia10.8HBB, FCGR2A, GYPA, CR1, SLC4A1
42ulcerative colitis10.8TNF, ICAM1, IFNG, IL10, NOS2
43diabetes mellitus10.8TNF, G6PD, ICAM1, HP, CD36
44myasthenia gravis10.8FCGR2A, IFNG, IL10, CR1
45lupus nephritis10.8CR1, IL10, ICAM1, FCGR2A
46sarcoidosis10.8CR1, IFNG, ICAM1, TNF
47congenital heart disease10.8TNF, ICAM1, IL10, HP
48colitis10.8TNF, IFNG, IL10, NOS2
49skin disease10.8TNF, ICAM1, IFNG, IL10
50hereditary spherocytosis10.7SLC4A1, GYPA, G6PD

Graphical network of the top 20 diseases related to Malaria:



Diseases related to malaria

Symptoms for Malaria

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Clinical features from OMIM:

611162

Drugs & Therapeutics for Malaria

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Genetic Tests for Malaria

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Anatomical Context for Malaria

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MalaCards organs/tissues related to Malaria:

32
Testes, Brain, T cells, Endothelial, Skin, Liver, Monocytes, B cells, Neutrophil, Spleen, Nk cells, Eye, Whole blood, Kidney, Placenta, Myeloid, Bone marrow, Bone, Cortex, Heart, Skeletal muscle, Lung, Temporal lobe, Hypothalamus, Cardiac myocytes, Pituitary

Animal Models for Malaria or affiliated genes

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Publications for Malaria

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Articles related to Malaria:

(show top 50)    (show all 3131)
idTitleAuthorsYear
1
Splenic infarction and malaria. (24942899)
2014
2
Preliminary Study of Quinine Pharmacokinetics in Pregnant Women with Malaria-HIV Co-Infection. (24420779)
2014
3
Marked Decline in Malaria Prevalence among Pregnant Women and Their Offspring from 1996 to 2010 on the South Kenyan Coast. (24080635)
2013
4
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
5
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. (24218563)
2013
6
Thymine distribution in genes provides novel insight into the functional significance of the proteome of the malaria parasite Plasmodium falciparum 3D7. (24132930)
2013
7
Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice. (24020374)
2013
8
Detection of a substantial number of sub-microscopic Plasmodium falciparum infections by polymerase chain reaction: a potential threat to malaria control and diagnosis in Ethiopia. (24090230)
2013
9
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
10
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. (22326740)
2012
11
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
12
Source of homologous parasites in recurrent Plasmodium vivax malaria. (22696499)
2012
13
Plasmodium berghei ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model. (21044627)
2011
14
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. (21689454)
2011
15
Therapeutic efficacy of chloroquine for treatment of Plasmodium vivax malaria cases in Halaba district, South Ethiopia. (21453465)
2011
16
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria. (21459194)
2011
17
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. (20105282)
2010
18
Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis. (20145098)
2010
19
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
20
The murine cerebral malaria phenomenon. (19932638)
2010
21
Screening mosquito house entry points as a potential method for integrated control of endophagic filariasis, arbovirus and malaria vectors. (20689815)
2010
22
Fluorescein angiography findings strengthen the theoretical basis for trialling neuroprotective agents in cerebral malaria. (19635680)
2009
23
Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas. (18266013)
2008
24
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
25
Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia. (18317566)
2008
26
Markers of vascular endothelial cell damage and P. falciparum malaria: association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation. (18775803)
2008
27
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. (18602399)
2008
28
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. (17997848)
2007
29
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. (17325227)
2007
30
Louse-borne relapsing fever and malaria co-infection in Ethiopia. (17540107)
2007
31
Aquaporin water and solute channels from malaria parasites and other pathogenic protozoa. (16892397)
2006
32
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
33
Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. (17447375)
2006
34
Effects of hydroxyurea on malaria, parasite growth and adhesion in experimental models. (17096647)
2006
35
Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. (16282291)
2005
36
Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance. (15642957)
2004
37
Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors. (15138068)
2004
38
Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. (14573655)
2003
39
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. (12433515)
2002
40
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. (12421634)
2002
41
Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine-pyrimethamine in vivax malaria pilot studies: relationship to Plasmodium vivax dhfr mutations. (12435700)
2002
42
Nitric oxide synthase 2(LambarAcnAc) (G-954C), increased nitric oxide production, and protection against malaria. (11443559)
2001
43
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. (10447880)
1999
44
IgE and tumor necrosis factor in malaria infection. (10065623)
1999
45
Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study. (10589898)
1999
46
Molecular characterization of the heat shock protein 90 gene of the human malaria parasite Plasmodium falciparum. (7838176)
1994
47
Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children. (7899791)
1994
48
Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria. (1565611)
1992
49
Common west African HLA antigens are associated with protection from severe malaria. (1865923)
1991
50
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. (1978068)
1990

Variations for Malaria

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Clinvar genetic disease variations for Malaria:

6
id Gene Name Type Significance SNP ID Assembly Location
1NM_013324.5(CISH): c.-524T> Asingle nucleotide variantrisk factorrs414171GRCh37Chr 3, 50649499: 50649499

Expression for genes affiliated with Malaria

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Expression patterns in normal tissues for genes affiliated with Malaria

Search GEO for disease gene expression data for Malaria.

Pathways for genes affiliated with Malaria

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Pathways related to Malaria according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.1GYPB, DARC, TNF, HBB, GYPC, GYPA
210.8FCGR2A, NOS2, TNF, CR1, FCGR2B, IFNG
3
Show member pathways
10.8IFNG, IL10, CR1, NOS2, TNF, FCGR2A
410.7IL10, IFNG, ICAM1, TNF, HBB
510.7ICAM1, IFNG, NOS2, FCGR2A, TNF
610.7CR1, TNF, GYPA, CD36
710.7NOS2, IL10, IFNG, TNF
8
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
10.7IL10, TNF, IFNG, NOS2
9
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.7TNF, IFNG, IL10, NOS2
1010.7TNF, ICAM1, IFNG, NOS2
11
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
10.7IL10, IFNG, FCGR2B, TNF
1210.7IL10, FCGR2A, FCGR2B, ICAM1
13
Show member pathways
thioredoxin pathway37
10.7IFNG, TNF, HBB, ICAM1
1410.7FCGR2B, IFNG, FCGR2A, TNF
15
Show member pathways
10.7ICAM1, IFNG, FCGR2B, TNF
16
Show member pathways
Immune response CD16 signaling in NK cells60
10.7IFNG, ICAM1, TNF, NCR3
17
Show member pathways
10.7IL10, TNF, ICAM1, IFNG
18
Show member pathways
10.6CD36, HP, HBB
1910.6NOS2, ICAM1, IFNG
2010.6TNF, IL10, NOS2
21
Show member pathways
Immune response MIF in innate immunity response60
10.6NOS2, IFNG, TNF
22
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
10.6TNF, NOS2, IFNG
23
Show member pathways
Type III interferon signaling37
10.6CISH, IFNG, IL10
2410.6FCGR2B, FCGR2A, CD36
2510.6TNF, ICAM1, HP
2610.6IFNG, IL10, TNF
27
Show member pathways
10.6IFNG, IL10, TNF
2810.6TNF, IL10, IFNG
29
Show member pathways
IL27-mediated signaling events37
10.6IL10, IFNG, TNF
3010.6ICAM1, IFNG, TNF
3110.6ICAM1, CD36, TNF
32
Show member pathways
10.6HBB, SLC4A1

Compounds for genes affiliated with Malaria

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Compounds related to Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 156)
idCompoundScoreTop Affiliating Genes
1serine4411.5TNF, CD36, HP, GYPB, GYPC, G6PD
2tyrosine4411.5SLC4A1, GYPB, GYPC, HP, ICAM1, CISH
3nitric oxide44 24 1113.5SLC4A1, NOS2, TNF, HBB, HP, ICAM1
4lipid4411.4HP, SLC4A1, GYPA, GYPC, G6PD, CISH
5cycloheximide4411.3TNF, HBB, ICAM1, IFNG, IL10, CD36
6h2o24411.3TNF, ICAM1, CD36, NOS2, HP, HBB
7endotoxin4411.3IL10, IFNG, ICAM1, TNF, NOS2, CR1
8dexamethasone44 50 28 1114.3TNF, CISH, ICAM1, IFNG, IL10, HP
9actinomycin d4411.2G6PD, ICAM1, NOS2, FCGR2A, TNF, HP
10natalizumab44 1112.2FCGR2B, ICAM1, IFNG, IL10, TNF, FCGR2A
11pge24411.2HP, CD36, ICAM1, NOS2, IL10, TNF
12adalimumab44 50 1113.2TNF, FCGR2B, IL10, IFNG, FCGR2A
13polymyxin b4411.2TNF, ICAM1, CR1, IL10, IFNG
14etanercept44 50 1113.2IFNG, TNF, FCGR2A, IL10, FCGR2B
15sb 20358044 6112.2NOS2, IFNG, ICAM1, TNF, CD36, IL10
16ivig4411.1FCGR2B, IL10, IFNG, FCGR2A, TNF
17pentoxifylline44 1112.1IL10, HP, TNF, ICAM1, IFNG
1815-deoxy-delta-12,14-prostaglandin j24411.1TNF, IFNG, IL10, NOS2, CD36
19neopterin4411.1IL10, IFNG, TNF, ICAM1, HP
20rituximab44 50 1113.1FCGR2B, HP, TNF, IL10, FCGR2A
21interferon gamma4411.1TNF, IFNG, IL10, ICAM1
22efalizumab44 1112.1FCGR2A, FCGR2B, ICAM1, TNF
23histamine44 28 2413.1TNF, FCGR2A, IL10, FCGR2B, ICAM1, IFNG
24ulinastatin4411.1TNF, ICAM1, HP, IL10
25prednisolone44 28 1113.1CR1, TNF, IL10, FCGR2A, IFNG
26ly2940024411.1ICAM1, FCGR2A, IL10, NOS2, TNF, CD36
27okt34411.1ICAM1, TNF, IL10, IFNG
28triptolide4411.1TNF, ICAM1, IFNG, NOS2
29gm-csf44 2812.0ICAM1, IFNG, IL10, TNF
30parthenolide44 212.0IFNG, TNF, NOS2, ICAM1
31budesonide44 50 1113.0TNF, ICAM1, IFNG, CD36
32herbimycin a44 6112.0CD36, IFNG, ICAM1, NOS2, TNF
33sulfasalazine28 44 50 1114.0ICAM1, HP, G6PD, TNF
348-isoprostane4411.0ICAM1, HP, IL10, TNF
35polyinosinic-polycytidylic acid4411.0IL10, NOS2, IFNG, TNF
36fmlp4411.0FCGR2B, CR1, TNF, ICAM1, FCGR2A
37cdp5714411.0IL10, ICAM1, TNF
38genistein44 28 61 2 24 1116.0TNF, NOS2, FCGR2B, ICAM1, IFNG, CD36
39mycophenolate mofetil44 50 1113.0CD36, TNF, IFNG, IL10
40diphenyleneiodonium4411.0ICAM1, G6PD, TNF, NOS2
41prostacyclin4410.9FCGR2A, TNF, ICAM1, IL10, NOS2
42tarc4410.9IL10, TNF, ICAM1, IFNG
43infliximab44 50 1112.9IL10, IFNG, FCGR2A, TNF
44ribavirin44 50 1112.8IL10, IFNG, HP, G6PD
4523-diphosphoglycerate4410.8HP, HBB, G6PD
46ccl344 2811.7IFNG, IL10, TNF, ICAM1
47dmso4410.7CR1, HBB, G6PD, IL10, CD36
48glyceraldehyde 3-phosphate4410.7G6PD, DARC, GYPC, SLC4A1, HBB
49calcium44 50 24 1113.7CD36, SERPINI1, GYPA, HP, CR1, NOS2
50cyclosporin a44 28 6112.7IFNG, IL10, HP, CR1, TNF, ICAM1

GO Terms for genes affiliated with Malaria

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Cellular components related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.3CISH, FCGR2B, FCGR2A, TNF, DARC, GYPB
2integral component of plasma membraneGO:00588711.1SLC4A1, TNF, GYPB, GYPC, GYPA, ICAM1
3external side of plasma membraneGO:00989710.8TNF, GYPA, ICAM1, IFNG, CD36
4cortical cytoskeletonGO:03086310.7SLC4A1, NOS2, GYPC
5extracellular spaceGO:00561510.7TNF, SERPINI1, ICAM1, IFNG, IL10, HP
6blood microparticleGO:07256210.6SLC4A1, HP, HBB
7haptoglobin-hemoglobin complexGO:03183810.6HBB, HP
8endocytic vesicle lumenGO:07168210.3HP, HBB

Biological processes related to Malaria according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1cellular response to lipopolysaccharideGO:07122211.1ICAM1, IFNG, IL10, NOS2, CD36
2inflammatory responseGO:00695411.0DARC, TNF, IL10, NCR3, NOS2
3negative regulation of growth of symbiont in hostGO:04413011.0CD36, IL10, IFNG, TNF
4positive regulation of nitric oxide biosynthetic processGO:04542911.0IFNG, ICAM1, HBB, TNF
5defense response to bacteriumGO:04274211.0IFNG, IL10, HP, NOS2
6positive regulation of vitamin D biosynthetic processGO:06055710.9IFNG, TNF
7positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9TNF, IFNG
8positive regulation of killing of cells of other organismGO:05171210.9IFNG, NOS2
9receptor biosynthetic processGO:03280010.8TNF, IL10
10response to drugGO:04249310.8TNF, ICAM1, IFNG, IL10
11negative regulation of cytokine secretion involved in immune responseGO:00274010.8IL10, TNF
12regulation of insulin secretionGO:05079610.8NOS2, IFNG, TNF
13positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, IFNG
14positive regulation of chemokine biosynthetic processGO:04508010.8TNF, IFNG
15positive regulation of membrane protein ectodomain proteolysisGO:05104410.7IFNG, TNF
16nitric oxide mediated signal transductionGO:00726310.7CD36, NOS2
17positive regulation of osteoclast differentiationGO:04567210.6TNF, IFNG
18protein import into nucleus, translocationGO:00006010.6IFNG, TNF
19positive regulation of cell deathGO:01094210.5HP, HBB
20negative regulation of interleukin-6 productionGO:03271510.3IL10, TNF

Molecular functions related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.6FCGR2B, FCGR2A
2hemoglobin bindingGO:03049210.3HP, HBB

Products for genes affiliated with Malaria

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Sources for Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
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