MCID: MLR004
MIFTS: 74

Malaria malady

Rare diseases, Infectious diseases categories

Summaries for Malaria

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MedlinePlus:33 Malaria is a serious disease caused by a parasite. you get it when an infected mosquito bites you. malaria is a major cause of death worldwide, but it is almost wiped out in the united states. the disease is mostly a problem in developing countries with warm climates. if you travel to these countries, you are at risk. there are four different types of malaria caused by four related parasites. the most deadly type occurs in africa south of the sahara desert. malaria symptoms include chills, flu-like symptoms, fever, vomiting, diarrhea, and jaundice. a blood test can diagnose it. it can be life-threatening. however, you can treat malaria with drugs. the type of drug depends on which kind of malaria you have and where you were infected. malaria can be prevented. when traveling to malaria-prone regions see your doctor for medicines that protect you wear insect repellent with deet cover up sleep under mosquito netting centers for disease control and prevention

MalaCards based summary: Malaria, also known as induced malaria, is related to plasmodium falciparum malaria and cerebral malaria. An important gene associated with Malaria is NOS2 (nitric oxide synthase 2, inducible), and among its related pathways are Malaria and Tuberculosis. The drugs hydroxychloroquine and hydroxychloroquine sulfate and the compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:9 A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle.

NIH Rare Diseases:42 Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. people who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. in general, malaria is a curable disease if diagnosed and treated promptly and correctly. treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired. last updated: 5/12/2011

CDC:4 Malaria is a mosquito-borne disease caused by a parasite. People with malaria often experience fever, chills, and flu-like illness. Left untreated, they may develop severe complications and die. In 2010 an estimated 219 million cases of malaria occurred worldwide and 660,000 people died, most (91%) in the African Region.

Wikipedia:64 Malaria is a mosquito-borne infectious disease of humans and other animals caused by parasitic... more...

Description from OMIM:46 611162

Aliases & Classifications for Malaria

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Malaria, Aliases & Descriptions:

Name: Malaria 31 9 42 46 11 44 33 61
 
Induced Malaria 9 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


External Ids:

Disease Ontology9 DOID:12365
ICD9CM28 084, 084.6
MeSH34 D008288
NCIt39 C34797

Related Diseases for Malaria

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Diseases in the Malaria family:

Malaria, Severe

Diseases related to Malaria via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 312)
idRelated DiseaseScoreTop Affiliating Genes
1plasmodium falciparum malaria33.2CD36, NOS2, CR1, HP, IL10, IFNG
2cerebral malaria33.2MIF, ICAM1, G6PD, TNF, IFNG, IL10
3plasmodium vivax malaria32.8DARC, G6PD
4thrombocytopenia31.8HP, FCGR2B, FCGR2A
5leishmaniasis31.7IFNG, IL10
6tuberculosis31.6TNF, HBB, MIF, IFNG, IL10, HP
7alpha thalassemia31.5G6PD, HBB
8blackwater fever31.5G6PD
9hemolytic anemia31.5HBB, G6PD, HP, CR1, SLC4A1
10glomerulonephritis31.4FCGR2A, ICAM1, MIF, CR1, NOS2
11deficiency anemia31.4HBB, FCGR2A, G6PD, MIF, HP, CR1
12encephalitis31.3NOS2, GYPC, DARC
13sepsis31.3TNF, FCGR2A, CISH, MIF, IL10, CR1
14pneumonia31.3TNF, GYPA, ICAM1, IL10, CR1
15sickle cell disease31.3HP, G6PD, HBB
16adult respiratory distress syndrome31.3TNF, MIF, CR1, NOS2
17visceral leishmaniasis31.3IFNG, IL10
18systemic lupus erythematosus31.2FCGR2A, CR1
19hereditary elliptocytosis31.2G6PD, GYPC, SLC4A1
20methemoglobinemia31.2G6PD, HP
21pre-eclampsia31.1HBB, ICAM1, IL10, HP, NOS2
22burkitt's lymphoma31.0HBB, FCGR2A, FCGR2B, CISH, ICAM1, IL10
23multiple sclerosis31.0TNF, ICAM1, MIF, IFNG, IL10, CR1
24glucosephosphate dehydrogenase deficiency31.0G6PD, HP
25septic shock30.9TNF, MIF, IL10, CR1, NOS2
26atopic dermatitis30.9TNF, ICAM1, MIF, IFNG, IL10
27melanoma30.9TNF, FCGR2A, CISH, GYPC, ICAM1, IFNG
28asthma30.9TNF, CISH, ICAM1, MIF, IFNG, IL10
29hemoglobinopathy30.9HBB, G6PD, HP
30autoimmune hemolytic anemia30.9G6PD, GYPA, HP
31hepatitis b30.8CR1, IL10, IFNG
32atopy30.8IL10, IFNG, MIF
33favism30.8G6PD, HP
34hemoglobinuria30.7G6PD, HP
35ischemia30.7NOS2, CR1, HP, ICAM1
36leukemia30.7TNF, HBB, CISH, GYPA, ICAM1, IFNG
37beta thalassemia30.3G6PD, HBB
38cerebritis11.2
39atherosclerosis10.9TNF, FCGR2A, G6PD, ICAM1, MIF, IL10
40ipex syndrome10.8DARC, TNF, HBB, FCGR2A, GYPC, IFNG
41inflammatory bowel disease10.8DARC, TNF, ICAM1, MIF, IFNG, IL10
42ulcerative colitis10.8TNF, ICAM1, MIF, IFNG, IL10, NOS2
43sarcoidosis10.8CR1, IFNG, MIF, ICAM1, TNF
44colitis10.8TNF, MIF, IFNG, IL10, NOS2
45acute erythroid leukemia10.8HBB, FCGR2A, GYPA, CR1, SLC4A1
46myasthenia gravis10.8CR1, IL10, IFNG, FCGR2A
47diabetes mellitus10.8TNF, G6PD, ICAM1, HP, CD36
48lupus nephritis10.8FCGR2A, ICAM1, IL10, CR1
49glomerulosclerosis10.8MIF, CR1, NOS2, CD36
50galactosemia10.8HP, IL10, ICAM1, TNF

Graphical network of the top 20 diseases related to Malaria:



Diseases related to malaria

Symptoms for Malaria

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Clinical features from OMIM:

611162

Drugs & Therapeutics for Malaria

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Genetic Tests for Malaria

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Anatomical Context for Malaria

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MalaCards organs/tissues related to Malaria:

32
Testes, Brain, T cells, Endothelial, Skin, Liver, Monocytes, B cells, Neutrophil, Spleen, Nk cells, Eye, Whole blood, Kidney, Placenta, Myeloid, Bone marrow, Bone, Cortex, Heart, Skeletal muscle, Lung, Temporal lobe, Hypothalamus, Cardiac myocytes, Pituitary

Animal Models for Malaria or affiliated genes

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Publications for Malaria

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Articles related to Malaria:

(show top 50)    (show all 3131)
idTitleAuthorsYear
1
Splenic infarction and malaria. (24942899)
2014
2
Preliminary Study of Quinine Pharmacokinetics in Pregnant Women with Malaria-HIV Co-Infection. (24420779)
2014
3
Marked Decline in Malaria Prevalence among Pregnant Women and Their Offspring from 1996 to 2010 on the South Kenyan Coast. (24080635)
2013
4
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
5
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. (24218563)
2013
6
Thymine distribution in genes provides novel insight into the functional significance of the proteome of the malaria parasite Plasmodium falciparum 3D7. (24132930)
2013
7
Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice. (24020374)
2013
8
Detection of a substantial number of sub-microscopic Plasmodium falciparum infections by polymerase chain reaction: a potential threat to malaria control and diagnosis in Ethiopia. (24090230)
2013
9
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
10
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. (22326740)
2012
11
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
12
Source of homologous parasites in recurrent Plasmodium vivax malaria. (22696499)
2012
13
Plasmodium berghei ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model. (21044627)
2011
14
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. (21689454)
2011
15
Therapeutic efficacy of chloroquine for treatment of Plasmodium vivax malaria cases in Halaba district, South Ethiopia. (21453465)
2011
16
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria. (21459194)
2011
17
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. (20105282)
2010
18
Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis. (20145098)
2010
19
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
20
The murine cerebral malaria phenomenon. (19932638)
2010
21
Screening mosquito house entry points as a potential method for integrated control of endophagic filariasis, arbovirus and malaria vectors. (20689815)
2010
22
Fluorescein angiography findings strengthen the theoretical basis for trialling neuroprotective agents in cerebral malaria. (19635680)
2009
23
Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas. (18266013)
2008
24
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
25
Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia. (18317566)
2008
26
Markers of vascular endothelial cell damage and P. falciparum malaria: association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation. (18775803)
2008
27
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. (18602399)
2008
28
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. (17997848)
2007
29
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. (17325227)
2007
30
Louse-borne relapsing fever and malaria co-infection in Ethiopia. (17540107)
2007
31
Aquaporin water and solute channels from malaria parasites and other pathogenic protozoa. (16892397)
2006
32
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
33
Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. (17447375)
2006
34
Effects of hydroxyurea on malaria, parasite growth and adhesion in experimental models. (17096647)
2006
35
Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. (16282291)
2005
36
Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance. (15642957)
2004
37
Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors. (15138068)
2004
38
Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. (14573655)
2003
39
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. (12433515)
2002
40
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. (12421634)
2002
41
Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine-pyrimethamine in vivax malaria pilot studies: relationship to Plasmodium vivax dhfr mutations. (12435700)
2002
42
Nitric oxide synthase 2(LambarAcnAc) (G-954C), increased nitric oxide production, and protection against malaria. (11443559)
2001
43
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. (10447880)
1999
44
IgE and tumor necrosis factor in malaria infection. (10065623)
1999
45
Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study. (10589898)
1999
46
Molecular characterization of the heat shock protein 90 gene of the human malaria parasite Plasmodium falciparum. (7838176)
1994
47
Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children. (7899791)
1994
48
Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria. (1565611)
1992
49
Common west African HLA antigens are associated with protection from severe malaria. (1865923)
1991
50
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. (1978068)
1990

Variations for Malaria

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Clinvar genetic disease variations for Malaria:

7
id Gene Name Type Significance SNP ID Assembly Location
1NM_013324.5(CISH): c.-524T> Asingle nucleotide variantrisk factorrs414171GRCh37Chr 3, 50649499: 50649499

Expression for genes affiliated with Malaria

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LifeMap Discovery
Genes differentially expressed in tissues of Malaria patients vs. healthy controls: 31 (show all 79)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)Blood+3.310.000
2C1QBcomplement component 1, q subcomponent, B chainBlood+3.100.000
3KIAA1210KIAA1210Blood+2.910.000
4DMRT2doublesex and mab-3 related transcription factor 2Blood+2.840.000
5SELMselenoprotein MBlood+2.530.000
6LAG3lymphocyte-activation gene 3Blood+2.490.000
7C19orf59chromosome 19 open reading frame 59Blood+2.340.000
8S100A12S100 calcium binding protein A12Blood+2.310.000
9PGLYRP1peptidoglycan recognition protein 1Blood+2.110.000
10ANKRD22ankyrin repeat domain 22Blood+2.080.000
11FCER1AFc fragment of IgE, high affinity I, receptor for; alpha polypeptideBlood-1.970.000
12CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)Blood+1.850.000
13S100PS100 calcium binding protein PBlood+1.820.000
14GPR84G protein-coupled receptor 84Blood+1.820.000
15LOC732229AN1-type zinc finger protein 5-likeBlood+1.810.002
16VNN1vanin 1Blood+1.800.000
17LILRA3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3Blood+1.780.000
18ELANEelastase, neutrophil expressedBlood+1.710.001
19ARG1arginase 1Blood+1.710.000
20SMPDL3Asphingomyelin phosphodiesterase, acid-like 3ABlood+1.680.000
21IL1R2interleukin 1 receptor, type IIBlood+1.670.002
22CTSLcathepsin LBlood+1.660.000
23C1QCcomplement component 1, q subcomponent, C chainBlood+1.630.000
24COA7cytochrome c oxidase assembly factor 7 (putative)Blood+1.620.009
25RETNresistinBlood+1.620.002
26GBP1guanylate binding protein 1, interferon-inducibleBlood+1.620.000
27OLFM4olfactomedin 4Blood+1.610.004
28IL18R1interleukin 18 receptor 1Blood+1.600.000
29CLCCharcot-Leyden crystal galectinBlood-1.590.002
30DHRS9dehydrogenase/reductase (SDR family) member 9Blood+1.560.000
31DEFA1Bdefensin, alpha 1BBlood+1.550.017
32MMP8matrix metallopeptidase 8 (neutrophil collagenase)Blood+1.530.003
33PSTPIP2proline-serine-threonine phosphatase interacting protein 2Blood+1.530.000
34FCGR1AFc fragment of IgG, high affinity Ia, receptor (CD64)Blood+1.530.000
35DEFA4defensin, alpha 4, corticostatinBlood+1.520.014
36TNFAIP6tumor necrosis factor, alpha-induced protein 6Blood+1.490.002
37HPhaptoglobinBlood+1.480.002
38DEFA3defensin, alpha 3, neutrophil-specificBlood+1.480.023
39EBI3Epstein-Barr virus induced 3Blood+1.470.000
40LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6Blood+1.460.001
41HK3hexokinase 3 (white cell)Blood+1.460.000
42BCL6B-cell CLL/lymphoma 6Blood+1.430.000
43MGAMmaltase-glucoamylase (alpha-glucosidase)Blood+1.430.000
44CA4carbonic anhydrase IVBlood+1.420.006
45CD177CD177 moleculeBlood+1.400.009
46SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1Blood+1.400.008
47SAMSN1SAM domain, SH3 domain and nuclear localization signals 1Blood+1.390.001
48LRRN3leucine rich repeat neuronal 3Blood-1.390.000
49ANXA3annexin A3Blood+1.380.005
50DYSFdysferlinBlood+1.370.001
51GBP5guanylate binding protein 5Blood+1.360.005
52FCGR1BFc fragment of IgG, high affinity Ib, receptor (CD64)Blood+1.360.010
53FCGBPFc fragment of IgG binding proteinBlood-1.350.000
54GYG1glycogenin 1Blood+1.350.000
55TCN1transcobalamin I (vitamin B12 binding protein, R binder family)Blood+1.330.014
56STOMstomatinBlood+1.300.008
57MAP3K7CLMAP3K7 C-terminal likeBlood-1.280.013
58B4GALT5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5Blood+1.280.007
59FCGR1CFc fragment of IgG, high affinity Ic, receptor (CD64), pseudogeneBlood+1.270.025
60BCL3B-cell CLL/lymphoma 3Blood+1.270.005
61PADI4peptidyl arginine deiminase, type IVBlood+1.270.018
62EMR1egf-like module containing, mucin-like, hormone receptor-like 1Blood+1.260.028
63CLEC4DC-type lectin domain family 4, member DBlood+1.260.031
64LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5Blood+1.260.021
65SIGLEC5sialic acid binding Ig-like lectin 5Blood+1.250.014
66CTLA4cytotoxic T-lymphocyte-associated protein 4Blood+1.250.020
67ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix proteinBlood-1.250.002
68LGALS2lectin, galactoside-binding, soluble, 2Blood-1.240.022
69TCL1AT-cell leukemia/lymphoma 1ABlood-1.220.040
70IRAK3interleukin-1 receptor-associated kinase 3Blood+1.220.022
71HIST2H2AA3histone cluster 2, H2aa3Blood+1.220.034
72VPREB3pre-B lymphocyte 3Blood-1.210.043
73HMOX1heme oxygenase (decycling) 1Blood+1.200.044
74C3AR1complement component 3a receptor 1Blood+1.200.037
75HIST2H2AA4histone cluster 2, H2aa4Blood+1.200.038
76SBNO2strawberry notch homolog 2 (Drosophila)Blood+1.170.030
77ADCY3adenylate cyclase 3Blood+1.160.031
78HVCN1hydrogen voltage-gated channel 1Blood-1.160.024
79HIST1H2BDhistone cluster 1, H2bdBlood+1.150.047

Expression patterns in normal tissues for genes affiliated with Malaria

Search GEO for disease gene expression data for Malaria.

Pathways for genes affiliated with Malaria

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Pathways related to Malaria according to GeneCards/GeneDecks:

(show all 32)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.0DARC, TNF, HBB, GYPB, GYPC, GYPA
210.8FCGR2A, IFNG, FCGR2B, CR1, NOS2, IL10
3
Show member pathways
10.8TNF, FCGR2A, IFNG, IL10, CR1, NOS2
410.7NOS2, MIF, ICAM1, FCGR2A, IFNG, TNF
510.7IL10, IFNG, ICAM1, HBB, TNF
610.7MIF, IFNG, NOS2, ICAM1, TNF
710.7CD36, CR1, GYPA, TNF
810.7NOS2, IFNG, IL10, TNF
9
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
10.7IFNG, NOS2, TNF, IL10
10
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
10.7TNF, IFNG, IL10, NOS2
11
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
10.7IL10, TNF, FCGR2B, IFNG
1210.7ICAM1, FCGR2B, IL10, FCGR2A
13
Show member pathways
thioredoxin pathway37
10.7IFNG, TNF, HBB, ICAM1
14
Show member pathways
Immune response MIF in innate immunity response59
10.7MIF, IFNG, NOS2, TNF
1510.7TNF, IFNG, FCGR2B, FCGR2A
16
Show member pathways
10.7IFNG, FCGR2B, ICAM1, TNF
17
Show member pathways
Immune response CD16 signaling in NK cells59
10.7ICAM1, NCR3, IFNG, TNF
18
Show member pathways
10.7ICAM1, IFNG, TNF, IL10
19
Show member pathways
10.6CD36, HP, HBB
2010.6IFNG, ICAM1, NOS2
2110.6IL10, TNF, NOS2
22
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
10.6IFNG, NOS2, TNF
23
Show member pathways
Type III interferon signaling37
10.6IL10, IFNG, CISH
2410.6CD36, FCGR2A, FCGR2B
2510.6HP, ICAM1, TNF
2610.6TNF, IL10, IFNG
27
Show member pathways
10.6IL10, TNF, IFNG
28
Show member pathways
IL27-mediated signaling events37
10.6IL10, TNF, IFNG
2910.6IL10, TNF, IFNG
3010.6ICAM1, IFNG, TNF
3110.6CD36, ICAM1, TNF
32
Show member pathways
10.6HBB, SLC4A1

Compounds for genes affiliated with Malaria

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Compounds related to Malaria according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.5CR1, SLC4A1, HP, MIF, ICAM1, GYPC
2nitric oxide44 25 1213.4IL10, TNF, SLC4A1, NOS2, CR1, HP
3lipid4411.4FCGR2A, TNF, DARC, GYPA, MIF, HP
4serine4411.4FCGR2B, TNF, FCGR2A, HBB, CISH, CD36
5h2o24411.3TNF, NOS2, HBB, FCGR2A, G6PD, CD36
6dexamethasone44 50 29 1214.3TNF, HP, NOS2, CISH, ICAM1, MIF
7endotoxin4411.3ICAM1, MIF, IFNG, TNF, NOS2, HP
8pge24411.3TNF, CD36, NOS2, HP, IL10, MIF
9cycloheximide4411.3NOS2, TNF, HBB, ICAM1, IFNG, IL10
10sb 20358044 6012.2TNF, NOS2, MIF, IFNG, IL10, ICAM1
11natalizumab44 1212.2FCGR2B, IL10, IFNG, ICAM1, FCGR2A, TNF
12actinomycin d4411.2HP, IFNG, ICAM1, G6PD, FCGR2A, TNF
13vegf4411.2MIF, CD36, NOS2, HP, IFNG, TNF
14genistein44 29 60 3 25 1216.2NOS2, TNF, IFNG, MIF, CD36, ICAM1
15herbimycin a44 6012.2NOS2, MIF, IFNG, TNF, ICAM1, CD36
16lactate4411.2HP, TNF, HBB, G6PD, ICAM1, MIF
17adalimumab44 50 1213.2FCGR2B, FCGR2A, IFNG, TNF, IL10
18thymidine44 2512.1IFNG, IL10, MIF, GYPC, FCGR2B, HBB
19polymyxin b4411.1CR1, TNF, ICAM1, IFNG, IL10
20etanercept44 50 1213.1FCGR2B, FCGR2A, TNF, IFNG, IL10
21ivig4411.1TNF, FCGR2A, FCGR2B, IFNG, IL10
22pentoxifylline44 1212.1IL10, TNF, ICAM1, IFNG, HP
23rantes4411.1DARC, IL10, IFNG, MIF, ICAM1, TNF
24interferon gamma4411.1IL10, IFNG, ICAM1, TNF
2515-deoxy-delta-12,14-prostaglandin j24411.1TNF, IFNG, IL10, NOS2, CD36
26neopterin4411.1HP, IFNG, ICAM1, TNF, IL10
27rituximab44 50 1213.1TNF, FCGR2A, FCGR2B, IL10, HP
28ulinastatin4411.1HP, IL10, ICAM1, TNF
29efalizumab44 1212.1TNF, ICAM1, FCGR2B, FCGR2A
30thalidomide44 50 60 1214.1CD36, IFNG, MIF, TNF, IL10
31tuberculin4411.0IFNG, HP, IL10, MIF
32prednisolone44 29 1213.0CR1, IL10, IFNG, FCGR2A, TNF
33oxygen44 2512.0HBB, ICAM1, MIF, FCGR2A, NOS2, CR1
34okt34411.0IFNG, IL10, ICAM1, TNF
35triptolide4411.0TNF, ICAM1, IFNG, NOS2
36hydrocortisone44 3 60 1214.0MIF, CD36, TNF, IFNG, IL10
37gm-csf44 2912.0TNF, ICAM1, IFNG, IL10
38parthenolide44 312.0TNF, ICAM1, IFNG, NOS2
39budesonide44 50 1212.9CD36, IFNG, TNF, ICAM1
40histamine44 29 2512.9TNF, FCGR2B, FCGR2A, ICAM1, IFNG, IL10
41estrogen4410.9NOS2, FCGR2B, CISH, HP, CD36, MIF
42sialic acid4410.9GYPB, HP, MIF, GYPA, GYPC
43sulfasalazine29 44 50 1213.9TNF, G6PD, HP, ICAM1
448-isoprostane4410.9ICAM1, IL10, TNF, HP
45cdp5714410.9IL10, TNF, ICAM1
46polyinosinic-polycytidylic acid4410.8NOS2, IL10, TNF, IFNG
47ly2940024410.8FCGR2A, ICAM1, IL10, TNF, NOS2, CD36
48fmlp4410.7FCGR2B, FCGR2A, TNF, ICAM1, CR1
49mycophenolate mofetil44 50 1212.6TNF, IFNG, IL10, CD36
50diphenyleneiodonium4410.4TNF, ICAM1, NOS2, G6PD

GO Terms for genes affiliated with Malaria

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Cellular components related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00588611.2FCGR2A, TNF, DARC, SLC4A1, FCGR2B, CISH
2integral component of plasma membraneGO:00588711.1NCR3, SLC4A1, CD36, TNF, CR1, ICAM1
3external side of plasma membraneGO:00989710.9TNF, GYPA, ICAM1, IFNG, CD36
4extracellular vesicular exosomeGO:07006210.9HP, CR1, SLC4A1, MIF, ICAM1, G6PD
5cortical cytoskeletonGO:03086310.8GYPC, NOS2, SLC4A1
6extracellular spaceGO:00561510.7HP, TNF, ICAM1, MIF, IFNG, IL10
7haptoglobin-hemoglobin complexGO:03183810.7HBB, HP
8blood microparticleGO:07256210.6SLC4A1, HP, HBB
9cell surfaceGO:00998610.6TNF, MIF, CR1, CD36
10endocytic vesicle lumenGO:07168210.3HP, HBB

Biological processes related to Malaria according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.1DARC, TNF, MIF, IL10, NCR3, NOS2
2cellular response to lipopolysaccharideGO:07122211.1ICAM1, IFNG, IL10, NOS2, CD36
3negative regulation of growth of symbiont in hostGO:04413011.0CD36, IL10, IFNG, TNF
4positive regulation of nitric oxide biosynthetic processGO:04542911.0IFNG, ICAM1, HBB, TNF
5defense response to bacteriumGO:04274211.0NOS2, HP, IL10, IFNG
6positive regulation of cytokine secretionGO:05071510.9TNF, MIF, IL10
7positive regulation of vitamin D biosynthetic processGO:06055710.9IFNG, TNF
8positive regulation of calcidiol 1-monooxygenase activityGO:06055910.9TNF, IFNG
9positive regulation of killing of cells of other organismGO:05171210.9IFNG, NOS2
10positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.9CD36, MIF, ICAM1
11receptor biosynthetic processGO:03280010.9TNF, IL10
12positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:200034310.9TNF, MIF
13negative regulation of gene expressionGO:01062910.9TNF, MIF, NOS2
14negative regulation of cytokine secretion involved in immune responseGO:00274010.8IL10, TNF
15response to drugGO:04249310.8TNF, ICAM1, IFNG, IL10
16positive regulation of MHC class II biosynthetic processGO:04534810.8IL10, IFNG
17regulation of insulin secretionGO:05079610.8NOS2, IFNG, TNF
18positive regulation of chemokine biosynthetic processGO:04508010.8IFNG, TNF
19positive regulation of membrane protein ectodomain proteolysisGO:05104410.7IFNG, TNF
20nitric oxide mediated signal transductionGO:00726310.7NOS2, CD36
21positive regulation of osteoclast differentiationGO:04567210.6IFNG, TNF
22negative regulation of interleukin-6 productionGO:03271510.6TNF, IL10
23protein import into nucleus, translocationGO:00006010.6IFNG, TNF
24positive regulation of cell deathGO:01094210.5HBB, HP
25cell surface receptor signaling pathwayGO:00716610.3CD36, IFNG, MIF

Molecular functions related to Malaria according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551511.0HP, SLC4A1, TNF, HBB, FCGR2B, CISH
2cytokine activityGO:00512510.7IL10, IFNG, MIF, TNF
3hemoglobin bindingGO:03049210.5HP, HBB
4IgG bindingGO:01986410.3FCGR2A, FCGR2B

Products for genes affiliated with Malaria

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Malaria

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet