MCID: MLR004
MIFTS: 81

Malaria malady

Genetic diseases, Rare diseases, Infectious diseases categories

Summaries for Malaria

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OMIM:45 Malaria, a major cause of child mortality worldwide, is caused by mosquito-borne hematoprotozoan parasites of the genus... (611162) more...

MalaCards based summary: Malaria, also known as malaria, cerebral, is related to plasmodium falciparum malaria and plasmodium vivax malaria. An important gene associated with Malaria is CR1 (complement component (3b/4b) receptor 1 (Knops blood group)), and among its related pathways are Malaria and Tuberculosis. The drugs chloroquine and hydroxychloroquine and the compounds tyrosine and nitric oxide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and t cells, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:9 A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by plasmodium species.

NIH Rare Diseases:41 Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. people who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. in general, malaria is a curable disease if diagnosed and treated promptly and correctly. treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired. last updated: 5/12/2011

MedlinePlus:32 Malaria is a serious disease caused by a parasite. you get it when an infected mosquito bites you. malaria is a major cause of death worldwide, but it is almost wiped out in the united states. the disease is mostly a problem in developing countries with warm climates. if you travel to these countries, you are at risk. there are four different types of malaria caused by four related parasites. the most deadly type occurs in africa south of the sahara desert. malaria symptoms include chills, flu-like symptoms, fever, vomiting, diarrhea, and jaundice. a blood test can diagnose it. it can be life-threatening. however, you can treat malaria with drugs. the type of drug depends on which kind of malaria you have and where you were infected. malaria can be prevented. when traveling to malaria-prone regions see your doctor for medicines that protect you wear insect repellent with deet cover up sleep under mosquito netting centers for disease control and prevention

CDC:3 FAQs, History, Disease, Geographic Distribution, Malaria Parasites, Mosquitoes, Eradication...

Wikipedia:63 Malaria is a mosquito-borne infectious disease of humans and other animals caused by parasitic... more...

Aliases & Classifications for Malaria

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Sources:
45OMIM, 30LifeMap Discovery®, 9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 37NCBI Bookshelf, 32MedlinePlus, 3CDC, 60UMLS, 55SNOMED-CT, 33MeSH, 27ICD9CM, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Malaria, Aliases & Descriptions:

Name: Malaria 45 30 9 41 11 43 47 32 3 60
Malaria, Cerebral 45 60
Induced Malaria 9 60
Malaria, Vivax, Protection Against 45
Malaria, Cerebral, Reduced Risk of 45
Malaria Due to G6pd Deficiency 45
 
Malaria, Protection Against 45
Malarial Encephalitis 9
Malaria Cerebral 43
Cerebral Malaria 9
Malaria, Severe 45
Cm 37


Classifications:



Characteristics (Orphanet epidemiological data):

47
malaria:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age


External Ids:

OMIM45 611162
Disease Ontology9 DOID:14069, DOID:12365
ICD9CM27 084, 084.6
NCIt38 C34797
Orphanet47 673
UMLS via Orphanet61 C0024530
MESH via Orphanet34 D008288
ICD1025 B54, B53.1

Related Diseases for Malaria

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Diseases related to Malaria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 418)
idRelated DiseaseScoreTop Affiliating Genes
1plasmodium falciparum malaria33.4CD36, NOS2, CR1, HBB, FCGR2A, G6PD
2plasmodium vivax malaria32.8DARC, G6PD
3thrombocytopenia31.9FCGR2A, FCGR2B, HP
4leishmaniasis31.8IL10, IFNG
5acute respiratory distress syndrome31.8TNF, CR1, NOS2
6tuberculosis31.7CR1, TIRAP, HBB, TNF, IFNG, IL10
7thalassemia31.7SLC4A1, G6PD, HBB
8glucose-6-phosphate dehydrogenase deficiency31.7HP, G6PD
9hemolytic anemia31.7HP, G6PD, HBB, CR1, SLC4A1
10blackwater fever31.5G6PD
11deficiency anemia31.5HP, G6PD, SLC4A1, FCGR2A, HBB, CR1
12encephalitis31.4GYPC, NOS2, DARC
13glomerulonephritis31.4FCGR2A, ICAM1, CR1, NOS2
14pneumonia31.4IL10, ICAM1, TNF, CR1, GYPA
15hereditary elliptocytosis31.4GYPC, SLC4A1, G6PD
16sickle cell disease31.3G6PD, HP, HBB
17visceral leishmaniasis31.3IFNG, IL10
18systemic lupus erythematosus31.2FCGR2A, CR1
19methemoglobinemia31.2HP, G6PD
20sickle cell anemia31.2HBB, G6PD, HP
21hemoglobinopathy31.1HBB, G6PD, HP
22melanoma31.1IL10, ICAM1, CR1, GYPC, IFNG, SLC4A1
23asthma31.0CR1, TNF, NOS2, IL10, IFNG, ICAM1
24atopic dermatitis31.0IL10, IFNG, ICAM1, TNF
25burkitt lymphoma30.9CR1, IL10, HBB, ICAM1, CISH, FCGR2B
26autoimmune hemolytic anemia30.9G6PD, GYPA, HP
27psoriasis30.9TNF, ICAM1, IL10, IFNG
28hepatitis b30.9IL10, CR1, IFNG
29leukemia30.9GYPA, ICAM1, IFNG, CISH, HBB, TNF
30favism30.8HP, G6PD
31ischemia30.8ICAM1, HP, CR1, NOS2
32hemoglobinuria30.8G6PD, HP
33cerebritis11.2
34atherosclerosis11.0HP, CD36, NOS2, ICAM1, G6PD, FCGR2A
35ipex syndrome11.0CR1, IL10, DARC, TNF, HBB, FCGR2A
36inflammatory bowel disease10.9IFNG, TNF, NOS2, DARC, IL10, ICAM1
37multiple sclerosis, disease progression, modifier of10.9ICAM1, IFNG, CR1, NOS2, TNF, IL10
38acute erythroid leukemia10.9FCGR2A, HBB, GYPA, CR1, SLC4A1
39ulcerative colitis10.9ICAM1, TNF, IFNG, IL10, NOS2
40preeclampsia/eclampsia 110.9NOS2, HP, IL10, HBB, ICAM1
41diabetes mellitus, insulin-dependent10.8G6PD, CD36, TNF, HP, ICAM1
42myasthenia gravis10.8IL10, FCGR2A, IFNG, CR1
43rheumatoid arthritis10.8CISH, CR1, TNF, FCGR2A, FCGR2B, NOS2
44lupus nephritis10.8FCGR2A, ICAM1, CR1, IL10
45liver disease10.8TNF, ICAM1, IL10, HP
46sarcoidosis 110.8ICAM1, CR1, IFNG, TNF
47colitis10.8IL10, NOS2, TNF, IFNG
48congenital heart disease10.8IL10, ICAM1, HP, TNF
49connective tissue disease10.8ICAM1, IL10, TNF, FCGR2B
50primary hyperoxaluria10.8HP, G6PD, FCGR2A, CR1

Graphical network of the top 20 diseases related to Malaria:



Diseases related to malaria

Symptoms for Malaria

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Clinical features from OMIM:

611162

Drugs & Therapeutics for Malaria

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Genetic Tests for Malaria

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Anatomical Context for Malaria

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MalaCards organs/tissues related to Malaria:

31
Brain, Testes, T cells, Liver, Endothelial, Skin, B cells, Monocytes, Neutrophil, Spleen, Nk cells, Eye, Kidney, Whole blood, Placenta, Myeloid, Bone marrow, Bone, Cortex, Lung, Retina, Heart, Skeletal muscle, Temporal lobe, Hypothalamus, Cardiac myocytes, Pituitary

Animal Models for Malaria or affiliated genes

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Publications for Malaria

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Articles related to Malaria:

(show top 50)    (show all 3220)
idTitleAuthorsYear
1
Malaria continues as a major public health problem. (25903275)
2015
2
PfRH5 as a candidate vaccine for Plasmodium falciparum malaria. (25704640)
2015
3
Splenic infarction and malaria. (24942899)
2014
4
Preliminary Study of Quinine Pharmacokinetics in Pregnant Women with Malaria-HIV Co-Infection. (24420779)
2014
5
Marked Decline in Malaria Prevalence among Pregnant Women and Their Offspring from 1996 to 2010 on the South Kenyan Coast. (24080635)
2013
6
Endemic Burkitt lymphoma is associated with strength and diversity of Plasmodium falciparum malaria stage-specific antigen antibody response. (23645841)
2013
7
TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection. (24218563)
2013
8
Thymine distribution in genes provides novel insight into the functional significance of the proteome of the malaria parasite Plasmodium falciparum 3D7. (24132930)
2013
9
Lipid peroxidation and antioxidant enzymes activity in Plasmodium vivax malaria patients evolving with cholestatic jaundice. (24020374)
2013
10
Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children. (22665809)
2012
11
Large-scale growth of the Plasmodium falciparum malaria parasite in a wave bioreactor. (22326740)
2012
12
Prevalence, features and risk factors for malaria co-infections amongst visceral leishmaniasis patients from Amudat Hospital, Uganda. (22506087)
2012
13
Source of homologous parasites in recurrent Plasmodium vivax malaria. (22696499)
2012
14
Plasmodium berghei ANKA: erythropoietin activates neural stem cells in an experimental cerebral malaria model. (21044627)
2011
15
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs. (21689454)
2011
16
Therapeutic efficacy of chloroquine for treatment of Plasmodium vivax malaria cases in Halaba district, South Ethiopia. (21453465)
2011
17
Antigenic Variation and the Genetics and Epigenetics of the PfEMP1 Erythrocyte Surface Antigens in Plasmodium falciparum Malaria. (21459194)
2011
18
Efficacy of amodiaquine, sulphadoxine-pyrimethamine and their combination for the treatment of uncomplicated Plasmodium falciparum malaria in children in Cameroon at the time of policy change to artemisinin-based combination therapy. (20105282)
2010
19
Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis. (20145098)
2010
20
Childhood Plasmodium falciparum malaria complicated by acute pancreatitis. (20555053)
2010
21
The murine cerebral malaria phenomenon. (19932638)
2010
22
Fluorescein angiography findings strengthen the theoretical basis for trialling neuroprotective agents in cerebral malaria. (19635680)
2009
23
Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria in endemic areas. (18266013)
2008
24
Surgery for temporal lobe epilepsy after cerebral malaria. (18515154)
2008
25
Reduced immune complex binding capacity and increased complement susceptibility of red cells from children with severe malaria-associated anemia. (18317566)
2008
26
Markers of vascular endothelial cell damage and P. falciparum malaria: association between levels of both sE-selectin and thrombomodulin, and cytokines, hemoglobin and clinical presentation. (18775803)
2008
27
Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity. (18602399)
2008
28
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children. (17997848)
2007
29
Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria. (17325227)
2007
30
Louse-borne relapsing fever and malaria co-infection in Ethiopia. (17540107)
2007
31
Aquaporin water and solute channels from malaria parasites and other pathogenic protozoa. (16892397)
2006
32
Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children. (16766006)
2006
33
Therapeutic efficacy of sulfadoxin/pyrimethamine in the treatment of uncomplicated Plasmodium falciparum malaria in Enseno, Meskan Woreda, Gurage zone, SNNPR, Ethiopia. (17447375)
2006
34
Effects of hydroxyurea on malaria, parasite growth and adhesion in experimental models. (17096647)
2006
35
Randomized, controlled, double-blind trial of daily oral azithromycin in adults for the prophylaxis of Plasmodium vivax malaria in Western Thailand. (16282291)
2005
36
Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance. (15642957)
2004
37
Translational up-regulation of antifolate drug targets in the human malaria parasite Plasmodium falciparum upon challenge with inhibitors. (15138068)
2004
38
Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. (14573655)
2003
39
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. (12433515)
2002
40
Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. (12421634)
2002
41
Therapeutic efficacies of artesunate-sulfadoxine-pyrimethamine and chloroquine-sulfadoxine-pyrimethamine in vivax malaria pilot studies: relationship to Plasmodium vivax dhfr mutations. (12435700)
2002
42
Nitric oxide synthase 2(LambarAcnAc) (G-954C), increased nitric oxide production, and protection against malaria. (11443559)
2001
43
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. (10447880)
1999
44
IgE and tumor necrosis factor in malaria infection. (10065623)
1999
45
Skeletal muscle involvement in falciparum malaria: biochemical and ultrastructural study. (10589898)
1999
46
Molecular characterization of the heat shock protein 90 gene of the human malaria parasite Plasmodium falciparum. (7838176)
1994
47
Plasmodium falciparum malaria: its effects on some haematological parameters in normal and sickle cell Nigerian children. (7899791)
1994
48
Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria. (1565611)
1992
49
Common west African HLA antigens are associated with protection from severe malaria. (1865923)
1991
50
TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. (1978068)
1990

Variations for Malaria

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Clinvar genetic disease variations for Malaria:

6
id Gene Variation Type Significance SNP ID Assembly Location
1NM_013324.5(CISH): c.-524T> Asingle nucleotide variantrisk factorrs414171GRCh37Chr 3, 50649499: 50649499

Expression for genes affiliated with Malaria

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LifeMap Discovery
Genes differentially expressed in tissues of Malaria patients vs. healthy controls: 30 (show all 73)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1NAIPNLR family, apoptosis inhibitory proteinBlood+3.740.000
2TNFAIP8L3tumor necrosis factor, alpha-induced protein 8-like 3Blood+3.720.000
3FLJ11292uncharacterized protein FLJ11292Blood+3.720.000
4BCL6B-cell CLL/lymphoma 6Blood+3.660.000
5METTL7Bmethyltransferase like 7BBlood+3.650.000
6GALNT14polypeptide N-acetylgalactosaminyltransferase 14Blood+3.600.000
7AP3B2adaptor-related protein complex 3, beta 2 subunitBlood+3.580.000
8ANXA3annexin A3Blood+3.560.000
9DAAM2dishevelled associated activator of morphogenesis 2Blood+3.550.000
10SERPING1serpin peptidase inhibitor, clade G (C1 inhibitor), member 1Blood+3.540.000
11TCN2transcobalamin IIBlood+3.540.000
12GBP6guanylate binding protein family, member 6Blood+3.530.000
13TCTEX1D1Tctex1 domain containing 1Blood+3.520.000
14LINC00937long intergenic non-protein coding RNA 937Blood+3.510.000
15PIM3pim-3 oncogeneBlood+3.490.000
16CARD17caspase recruitment domain family, member 17Blood+3.470.000
17MAP2K6mitogen-activated protein kinase kinase 6Blood+3.450.000
18BPIbactericidal/permeability-increasing proteinBlood+3.420.000
19LIPMlipase, family member MBlood+3.420.000
20UGCGUDP-glucose ceramide glucosyltransferaseBlood+3.400.000
21KCNJ15potassium inwardly-rectifying channel, subfamily J, member 15Blood+3.390.000
22MUC1mucin 1, cell surface associatedBlood+3.370.000
23TROtrophininBlood+3.350.000
24UG0898H09uncharacterized LOC643763Blood+3.350.000
25AIM2absent in melanoma 2Blood+3.340.000
26PFKFB36-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3Blood+3.310.000
27MT1Gmetallothionein 1GBlood+3.300.000
28STOMstomatinBlood+3.300.000
29CFBcomplement factor BBlood+3.300.000
30MIR205HGMIR205 host gene (non-protein coding)Blood+3.300.000
31KIF20Akinesin family member 20ABlood+3.290.000
32LINC00342long intergenic non-protein coding RNA 342Blood+3.290.000
33NECAB1N-terminal EF-hand calcium binding protein 1Blood+3.270.000
34HGFhepatocyte growth factor (hepapoietin A; scatter factor)Blood+3.260.000
35CEACAM8carcinoembryonic antigen-related cell adhesion molecule 8Blood+3.260.000
36TMOD3tropomodulin 3 (ubiquitous)Blood+3.240.000
37APOL1apolipoprotein L, 1Blood+3.240.000
38MS4A4Amembrane-spanning 4-domains, subfamily A, member 4ABlood+3.230.000
39ENTPD7ectonucleoside triphosphate diphosphohydrolase 7Blood+3.220.000
40GPR141G protein-coupled receptor 141Blood+3.220.000
41ZAKsterile alpha motif and leucine zipper containing kinase AZKBlood+3.220.000
42IL27interleukin 27Blood+3.210.000
43OPLAH5-oxoprolinase (ATP-hydrolysing)Blood+3.210.000
44OLFM4olfactomedin 4Blood+3.200.000
45TNFAIP6tumor necrosis factor, alpha-induced protein 6Blood+3.200.000
46TIFATRAF-interacting protein with forkhead-associated domainBlood+3.190.000
47IRAK3interleukin-1 receptor-associated kinase 3Blood+3.190.000
48VSIG4V-set and immunoglobulin domain containing 4Blood+3.190.000
49PDCD1LG2programmed cell death 1 ligand 2Blood+3.190.000
50LILRA5leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5Blood+3.190.000
51S100A12S100 calcium binding protein A12Blood+3.190.000
52SOCS3suppressor of cytokine signaling 3Blood+3.180.000
53EBI3Epstein-Barr virus induced 3Blood+3.170.000
54LIMK2LIM domain kinase 2Blood+3.150.000
55LRRN1leucine rich repeat neuronal 1Blood+3.150.000
56APOL6apolipoprotein L, 6Blood+3.140.000
57ACVR1Bactivin A receptor, type IBBlood+3.140.000
58KLF5Kruppel-like factor 5 (intestinal)Blood+3.140.000
59OTOFotoferlinBlood+3.120.000
60LINC01138long intergenic non-protein coding RNA 1138Blood+3.110.000
61KIF1Bkinesin family member 1BBlood+3.100.000
62SLC2A14solute carrier family 2 (facilitated glucose transporter), member 14Blood+3.090.000
63HIST2H2ABhistone cluster 2, H2abBlood+3.080.000
64RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic)Blood+3.080.000
65WDFY3WD repeat and FYVE domain containing 3Blood+3.080.000
66APOBEC3Bapolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3BBlood+3.070.000
67CLEC4DC-type lectin domain family 4, member DBlood+3.030.000
68MGAMmaltase-glucoamylase (alpha-glucosidase)Blood+3.020.000
69MAPK14mitogen-activated protein kinase 14Blood+3.020.000
70C2complement component 2Blood+3.010.000
71MKNK1MAP kinase interacting serine/threonine kinase 1Blood+3.010.000
72PLSCR4phospholipid scramblase 4Blood+3.010.000
73FAM225Afamily with sequence similarity 225, member A (non-protein coding)Blood+3.000.000

Search GEO for disease gene expression data for Malaria.

Pathways for genes affiliated with Malaria

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Pathways related to Malaria according to GeneCards Suite gene sharing:

(show all 34)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.4CD36, DARC, TNF, HBB, GYPB, GYPC
211.1TNF, FCGR2A, FCGR2B, TIRAP, IFNG, IL10
3
Show member pathways
11.0TNF, FCGR2A, IFNG, IL10, CR1, NOS2
410.9TNF, FCGR2A, ICAM1, IFNG, NOS2
510.9TNF, HBB, ICAM1, IFNG, IL10
6
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
10.9TNF, TIRAP, IFNG, IL10, NOS2
710.8TNF, GYPA, CR1, CD36
8
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
10.8TNF, TIRAP, NOS2, CD36
910.8NOS2, IFNG, ICAM1, TNF
10
Show member pathways
thioredoxin pathway36
10.8TNF, HBB, ICAM1, IFNG
1110.8IL10, ICAM1, FCGR2B, FCGR2A
1210.8TNF, TIRAP, IL10, NOS2
13
Show member pathways
Immune response MIF in innate immunity response58
10.8TNF, TIRAP, IFNG, NOS2
14
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
10.8TNF, TIRAP, IFNG, NOS2
1510.8IFNG, FCGR2B, FCGR2A, TNF
16
Show member pathways
10.8TNF, FCGR2B, ICAM1, IFNG
17
Show member pathways
Immune response CD16 signaling in NK cells58
10.8NCR3, IFNG, ICAM1, TNF
18
Show member pathways
10.8IL10, IFNG, ICAM1, TNF
19
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
10.8TNF, IFNG, IL10, NOS2
2010.8TNF, IFNG, IL10, NOS2
21
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
10.8TNF, FCGR2B, IFNG, IL10
2210.7CD36, ICAM1, TNF
2310.7CD36, FCGR2B, FCGR2A
2410.7ICAM1, TIRAP, TNF
2510.7HP, ICAM1, TNF
26
Show member pathways
10.7CD36, HP, HBB
2710.7ICAM1, IFNG, NOS2
2810.7IFNG, ICAM1, TNF
29
Show member pathways
10.7TNF, IFNG, IL10
30
Show member pathways
IL27-mediated signaling events36
10.7TNF, IFNG, IL10
3110.7IL10, IFNG, TNF
3210.7IL10, IFNG, TNF
33
Show member pathways
Type III interferon signaling36
10.7IL10, IFNG, CISH
34
Show member pathways
10.6HBB, SLC4A1

Compounds for genes affiliated with Malaria

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Compounds related to Malaria according to GeneCards Suite gene sharing:

(show top 50)    (show all 154)
idCompoundScoreTop Affiliating Genes
1tyrosine4311.9GYPB, DARC, SLC4A1, CR1, HP, ICAM1
2nitric oxide43 24 1213.7TNF, HBB, CISH, ICAM1, IFNG, HP
3lipid4311.7GYPC, GYPA, HP, G6PD, CISH, FCGR2B
4serine4311.7CISH, HP, CD36, GYPB, FCGR2B, FCGR2A
5cycloheximide4311.5ICAM1, IFNG, IL10, CR1, TNF, NOS2
6h2o24311.5CD36, HP, ICAM1, G6PD, FCGR2A, HBB
7dexamethasone43 49 28 1214.5CISH, NOS2, HP, TNF, IFNG, IL10
8endotoxin4311.5TNF, ICAM1, IFNG, IL10, CR1, HP
9actinomycin d4311.4TNF, HP, FCGR2A, NOS2, ICAM1, IFNG
10pge24311.4HP, TNF, IL10, NOS2, IFNG, ICAM1
11natalizumab43 1212.4TNF, IL10, ICAM1, IFNG, FCGR2B, FCGR2A
12sb 20358043 5912.3CD36, NOS2, IFNG, IL10, ICAM1, TNF
13adalimumab43 49 1213.3IFNG, TNF, FCGR2B, FCGR2A, IL10
14polymyxin b4311.3ICAM1, TNF, IFNG, CR1, IL10
15etanercept43 49 1213.3IL10, IFNG, FCGR2B, FCGR2A, TNF
16ivig4311.3FCGR2A, TNF, IL10, IFNG, FCGR2B
17pentoxifylline43 1212.3IL10, IFNG, ICAM1, HP, TNF
1815-deoxy-delta-12,14-prostaglandin j24311.3CD36, TNF, NOS2, IL10, IFNG
19neopterin4311.3ICAM1, IFNG, IL10, HP, TNF
20histamine43 28 2413.3FCGR2A, IL10, TNF, IFNG, FCGR2B, ICAM1
21rituximab43 49 1213.3TNF, FCGR2A, HP, IL10, FCGR2B
22ly2940024311.3TNF, FCGR2A, CD36, ICAM1, IL10, NOS2
23prednisolone43 28 1213.2CR1, TNF, FCGR2A, IL10, IFNG
24interferon gamma4311.2IL10, ICAM1, TNF, IFNG
25efalizumab43 1212.2TNF, ICAM1, FCGR2B, FCGR2A
26ulinastatin4311.2IL10, ICAM1, TNF, HP
27herbimycin a43 5912.2IFNG, ICAM1, CD36, TNF, NOS2
28okt34311.2IL10, IFNG, ICAM1, TNF
29triptolide4311.2TNF, NOS2, IFNG, ICAM1
30gm-csf43 2812.2IL10, IFNG, TNF, ICAM1
31budesonide43 49 1213.2IFNG, ICAM1, TNF, CD36
32parthenolide43 212.1ICAM1, NOS2, IFNG, TNF
33fmlp4311.1CR1, FCGR2A, TNF, FCGR2B, ICAM1
34sulfasalazine28 43 49 1214.1ICAM1, G6PD, HP, TNF
35genistein43 28 59 2 24 1216.1TNF, FCGR2B, ICAM1, IFNG, NOS2, CD36
368-isoprostane4311.1IL10, ICAM1, TNF, HP
37polyinosinic-polycytidylic acid4311.1IL10, IFNG, NOS2, TNF
38prostacyclin4311.1TNF, FCGR2A, ICAM1, IL10, NOS2
39mycophenolate mofetil43 49 1213.1TNF, CD36, IFNG, IL10
40diphenyleneiodonium4311.1ICAM1, TNF, NOS2, G6PD
41cdp5714311.1TNF, ICAM1, IL10
42vegf4311.0HP, IL10, IFNG, ICAM1, TNF, CD36
43tarc4311.0IL10, IFNG, ICAM1, TNF
44infliximab43 49 1213.0IL10, IFNG, FCGR2A, TNF
45ribavirin43 49 1212.9IFNG, G6PD, HP, IL10
46dmso4310.9CR1, CD36, G6PD, IL10, HBB
4723-diphosphoglycerate4310.9HBB, G6PD, HP
48ccl343 2811.9IFNG, TNF, ICAM1, IL10
49cyclosporin a43 28 5912.9IL10, ICAM1, CR1, HP, TNF, IFNG
50glyceraldehyde 3-phosphate4310.6SLC4A1, GYPC, G6PD, HBB, DARC

GO Terms for genes affiliated with Malaria

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Cellular components related to Malaria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:000588611.7SLC4A1, DARC, TNF, FCGR2A, FCGR2B, TIRAP
2integral component of plasma membraneGO:000588711.3TNF, GYPB, GYPC, GYPA, ICAM1, CR1
3external side of plasma membraneGO:000989710.9TNF, GYPA, ICAM1, IFNG, CD36
4cortical cytoskeletonGO:003086310.7GYPC, NOS2, SLC4A1
5blood microparticleGO:007256210.7SLC4A1, HP, HBB
6haptoglobin-hemoglobin complexGO:003183810.5HP, HBB
7endocytic vesicle lumenGO:007168210.3HP, HBB

Biological processes related to Malaria according to GeneCards Suite gene sharing:

(show all 30)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:000695411.3DARC, TNF, TIRAP, IL10, NCR3, NOS2
2negative regulation of growth of symbiont in hostGO:004413011.3CD36, IL10, IFNG, TIRAP, TNF
3cellular response to lipopolysaccharideGO:007122211.3ICAM1, IFNG, IL10, NOS2, CD36
4positive regulation of nitric oxide biosynthetic processGO:004542911.2IFNG, ICAM1, HBB, TNF
5defense response to bacteriumGO:004274211.2IFNG, IL10, HP, NOS2
6positive regulation of interleukin-12 productionGO:003273511.1CD36, IFNG, TIRAP
7defense response to Gram-positive bacteriumGO:005083011.1CD36, TIRAP, TNF
8positive regulation of tumor necrosis factor productionGO:003276011.1TIRAP, IFNG, CD36
9response to drugGO:004249311.0TNF, ICAM1, IFNG, IL10
10positive regulation of vitamin D biosynthetic processGO:006055711.0TNF, IFNG
11cellular response to bacterial lipopeptideGO:007122111.0TIRAP, CD36
12positive regulation of calcidiol 1-monooxygenase activityGO:006055911.0TNF, IFNG
13positive regulation of killing of cells of other organismGO:005171211.0IFNG, NOS2
14receptor biosynthetic processGO:003280011.0TNF, IL10
15regulation of insulin secretionGO:005079611.0TNF, IFNG, NOS2
16positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:0200034310.9TNF, TIRAP
17negative regulation of cytokine secretion involved in immune responseGO:000274010.9IL10, TNF
18cellular response to lipoteichoic acidGO:007122310.9TIRAP, CD36
19positive regulation of interleukin-6 biosynthetic processGO:004541010.9TIRAP, IFNG
20positive regulation of MHC class II biosynthetic processGO:004534810.9IFNG, IL10
21positive regulation of NF-kappaB transcription factor activityGO:005109210.9TNF, TIRAP, ICAM1
22positive regulation of chemokine biosynthetic processGO:004508010.9IFNG, TNF
23positive regulation of membrane protein ectodomain proteolysisGO:005104410.8IFNG, TNF
24nitric oxide mediated signal transductionGO:000726310.8CD36, NOS2
25positive regulation of osteoclast differentiationGO:004567210.7IFNG, TNF
26negative regulation of interleukin-6 productionGO:003271510.7TNF, IL10
27positive regulation of cell deathGO:001094210.6HBB, HP
28protein import into nucleus, translocationGO:000006010.6IFNG, TNF
29positive regulation of I-kappaB kinase/NF-kappaB signalingGO:004312310.6CD36, TIRAP, TNF
30cell surface receptor signaling pathwayGO:000716610.4TIRAP, IFNG, CD36

Molecular functions related to Malaria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:000551511.4HBB, FCGR2B, TIRAP, CISH, G6PD, GYPC
2protein homodimerization activityGO:004280310.8SLC4A1, NOS2, GYPA, G6PD, TIRAP
3hemoglobin bindingGO:003049210.6HP, HBB
4IgG bindingGO:001986410.3FCGR2A, FCGR2B

Products for genes affiliated with Malaria

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Malaria

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet