MCID: MLB002
MIFTS: 54

Male Breast Cancer malady

Cancer diseases category

Summaries for Male Breast Cancer

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Sources:
33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Although breast cancer is much more common in women, men can get it too. it happens most often to men between the ages of 60 and 70. breast lumps usually aren't cancer. however, most men with breast cancer have lumps. other breast symptoms can include dimpled or puckered skin a red, scaly nipple or skin fluid discharge risk factors for male breast cancer include exposure to radiation, a family history of breast cancer, and having high estrogen levels, which can happen with diseases like cirrhosis or klinefelter's syndrome. treatment for male breast cancer is usually a mastectomy, which is surgery to remove the breast. other treatments include radiation, chemotherapy and/or hormone therapy. nih: national cancer institute

MalaCards: Male Breast Cancer, also known as male breast carcinoma, is related to breast cancer and bilateral breast cancer. An important gene associated with Male Breast Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Integrated Breast Cancer Pathway and Meiotic Synapsis. The compounds 8-oxoguanine and daidzein have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and prostate.

Wikipedia:63 Male breast cancer (male breast neoplasm) is a relatively rare cancer in men that originates from the... more...

Description from OMIM:46 114480

Aliases & Classifications for Male Breast Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 46OMIM, 22GTR, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

male breast cancer 8 42 33
male breast carcinoma 42 22
breast cancer, male 42 46
malignant neoplasm of male breast 8
carcinoma of male breast 60
neoplasm of male breast 8
breast male carcinoma 44
breast cancer in men 42


External Ids:

Disease Ontology8 DOID:1614
SNOMED-CT56 126937006
ICD9CM27 175.9

Related Diseases for Male Breast Cancer

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Male Breast Cancer:



Diseases related to male breast cancer

Clinical Features for Male Breast Cancer

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Sources:
46OMIM
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Clinical features from OMIM:

114480

Drugs & Therapeutics for Male Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Male Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Male Breast Cancer

Search NIH Clinical Center for Male Breast Cancer

Search CenterWatch for Male Breast Cancer

Genetic Tests for Male Breast Cancer

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Sources:
22GTR
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Genetic tests related to Male Breast Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Male Breast22

Anatomical Context for Male Breast Cancer

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32MalaCards
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MalaCards organs/tissues related to Male Breast Cancer:

32
Breast, Skin, Prostate, Lymph node, Lung, Pituitary, Thyroid, Brain, Testes, Spinal cord

Animal Models for Male Breast Cancer or affiliated genes

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Publications for Male Breast Cancer

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50PubMed
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Articles related to Male Breast Cancer:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Prognostic factors for male breast cancer: similarity to female counterparts. (23645780)
2013
2
Outcomes of partial mastectomy in male breast cancer patients: analysis of SEER, 1983-2009. (23460016)
2013
3
Contemporary Systemic Therapy for Male Breast Cancer. (24220158)
2013
4
Management of male breast cancer in the United States: a surveillance, epidemiology and end results analysis. (24138917)
2013
5
An update on male breast cancer and future directions for research and treatment. (23545364)
2013
6
Localized therapy for male breast cancer: functional advantages with comparable outcomes using breast conservation. (23891587)
2013
7
Male breast cancer: 20-year survival data for post-mastectomy radiotherapy. (24132074)
2013
8
Male breast cancer presenting with bilateral pleural effusion. (23378963)
2013
9
Clinical and pathologic characteristics of BRCA-positive and BRCA-negative male breast cancer patients: results from a collaborative multicenter study in Italy. (22527108)
2012
10
Evolving trends in the initial locoregional management of male breast cancer. (22321249)
2012
11
Male breast cancer in Indian patients: is it the same? (23238143)
2012
12
Imaging male breast cancer. (21745659)
2011
13
A case report of male breast cancer in a very young patient: what is changing? (21291532)
2011
14
Rare male breast cancer has similarities to female disease. (21213581)
2010
15
Etiologic factors for male breast cancer in the U.S. Veterans Affairs medical care system database. (19330525)
2010
16
Male breast cancer: a survey at the Helsinki University Central Hospital during 1981-2006. (20397767)
2010
17
Male breast cancer presenting as an axillary mass: a case report and literature review. (19487992)
2009
18
Male breast cancer in Tripoli, Libya. (19668888)
2009
19
MicroRNA expression profiling of male breast cancer. (19664288)
2009
20
BRCA1/2 mutation analysis in male breast cancer families from North West England. (17636422)
2008
21
Male Breast Cancer. (20824037)
2008
22
Bilateral breast cancer in a male patient with hepatocellular carcinoma. A case report. (18727274)
2008
23
Breast conserving surgery with preservation of the nipple-areola complex as a feasible and safe approach in male breast cancer: a case report. (18442386)
2008
24
Some aspects of the endocrine profile and management of hormone-dependent male breast cancer. (17673611)
2007
25
Male breast cancer: a review of clinical management. (17033919)
2007
26
BRCA2 mutations in 154 finnish male breast cancer patients. (15548363)
2004
27
Some unusual paraneoplastic syndromes. Case 3. Metastatic pulmonary calcification causing hypoxemia in male breast cancer. (12829686)
2003
28
Loss of heterozygosity and microsatellite instability in male breast cancer. (11836619)
2002
29
Overexpression of plasminogen activator in male breast cancer. (11899788)
2001
30
Male breast cancer in Cowden syndrome patients with germline PTEN mutations. (11238682)
2001
31
Male breast cancer. An analysis of four cases and review of the literature. (11677920)
2001
32
Genetic analyses of male breast cancer in Israel. (11142766)
2000
33
Sentinel node biopsy in male breast cancer. (10419720)
1999
34
Expression and clinical significance of apolipoprotein D in male breast cancer and gynaecomastia. (10504376)
1999
35
Frequent loss of heterozygosity at chromosome 13q12-13 with BRCA2 markers in sporadic male breast cancer. (9646036)
1998
36
Case-control study of occupational exposures and male breast cancer. (9861181)
1998
37
Analysis of Swedish male breast cancer family data: a simple way to incorporate a common sibling effect. (9554557)
1998
38
Hereditary breast cancer in 19 females and 2 males: Kindred, P.G. 1940. (7718340)
1995
39
Male breast cancer: results of the treatments and prognostic factors in 397 cases. (8562148)
1995
40
High rate of male breast cancer in the Falklands. (8334488)
1993
41
Breast cancer risks in relatives of male breast cancer patients. (1619685)
1992
42
Electromagnetic field exposure and male breast cancer. (1672204)
1991
43
Management of male breast cancer. (1829945)
1991
44
Male breast cancer in renal allograft recipient. (3284609)
1988
45
Advanced male breast cancer treatment with the LH-RH analogue buserelin alone or in combination with the antiandrogen flutamide. (3134119)
1988
46
Report of two cases of male breast cancer after prolonged estrogen treatment for prostatic carcinoma. (3017556)
1986
47
Risk factors for male breast cancer. (3856050)
1985
48
Hormonal treatment of disseminated male breast cancer. (2933617)
1985
49
Hormonal therapy with tamoxifen in male breast cancer. (221118)
1979
50
Detection of the estrogen receptor and response to endocrine therapy in male breast cancer patients. (199520)
1977

Genetic Variations for Male Breast Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Male Breast Cancer:

62 (show all 70)
id Symbol AA change Variation ID SNP ID
1AKT1p.Glu17LysVAR_055422rs121434592
2BRCA1p.Leu22SerVAR_007756
3BRCA1p.Cys61GlyVAR_007757rs28897672
4BRCA1p.Cys64GlyVAR_007758
5BRCA1p.Val271MetVAR_007761rs80357244
6BRCA1p.Phe461LeuVAR_007765rs56046357
7BRCA1p.Tyr465AspVAR_007766
8BRCA1p.Gly552ValVAR_007768
9BRCA1p.Leu892SerVAR_007775
10BRCA1p.Gly960AspVAR_007776
11BRCA1p.Thr1025IleVAR_007778
12BRCA1p.Val1047AlaVAR_007781
13BRCA1p.Pro1150SerVAR_007782rs80357272
14BRCA1p.Ala1708GluVAR_007796rs28897696
15BRCA1p.Met1775ArgVAR_007799
16BRCA1p.Glu10LysVAR_020679
17BRCA1p.Glu23LysVAR_020680
18BRCA1p.Asp749TyrVAR_020683
19BRCA1p.Ser1187IleVAR_020690
20BRCA1p.Gln1200HisVAR_020691rs56214134
21BRCA1p.Arg1204IleVAR_020692
22BRCA1p.Lys1207AsnVAR_020693
23BRCA1p.Ser1217TyrVAR_020695
24BRCA1p.Arg1699TrpVAR_020703
25BRCA1p.Met1775LysVAR_063212
26BRCA2p.Phe32LeuVAR_005085
27BRCA2p.Lys53ArgVAR_005086
28BRCA2p.Phe81LeuVAR_005088
29BRCA2p.Pro201ArgVAR_005089
30BRCA2p.Val211AlaVAR_005090
31BRCA2p.Pro222SerVAR_005091
32BRCA2p.Cys554TrpVAR_005095
33BRCA2p.Asp728AlaVAR_005097
34BRCA2p.Gly2274ValVAR_005105
35BRCA2p.His2415AsnVAR_005106
36BRCA2p.Gln2421HisVAR_005107
37BRCA2p.Met3118ThrVAR_005110
38BRCA2p.Thr3357ArgVAR_005111
39BRCA2p.Glu2089AspVAR_008783
40BRCA2p.Thr2722ArgVAR_018661
41BRCA2p.Ser1179AsnVAR_020715
42BRCA2p.Cys1580TyrVAR_020719
43BRCA2p.Thr1679IleVAR_020720
44BRCA2p.Val1804AlaVAR_020721
45BRCA2p.Glu1901LysVAR_020722
46BRCA2p.Ser2072CysVAR_020725
47BRCA2p.Tyr2094CysVAR_020726
48BRCA2p.Pro2096LeuVAR_020727
49BRCA2p.Lys2128AsnVAR_020729
50BRCA2p.Val2728IleVAR_020736rs28897749
51BRCA2p.Lys2729AsnVAR_020737rs80359065
52BRCA2p.Asn3124IleVAR_020743
53BRCA2p.Lys3196GluVAR_020744rs80359228
54BRCA2p.Gly25ArgVAR_028167
55BRCA2p.Trp31CysVAR_028168
56BRCA2p.Trp31ArgVAR_028169
57BRCA2p.Thr64IleVAR_032712
58BRCA2p.Ser326ArgVAR_032717rs28897706
59BRCA2p.Ile505ThrVAR_032718rs28897708
60BRCA2p.Ile729MetVAR_032719
61BRCA2p.Lys1690AsnVAR_032722
62BRCA2p.Asn1730TyrVAR_032723
63BRCA2p.Thr1887MetVAR_032724
64BRCA2p.Asn2135HisVAR_032728
65BRCA2p.Tyr2222CysVAR_032729
66BRCA2p.Gln2456GluVAR_032731
67BRIP1p.Pro47AlaVAR_020896rs28903098
68BRIP1p.Met299IleVAR_020900
69NBNp.Leu150PheVAR_025795
70RAD51p.Arg150GlnVAR_010899rs121917739

Expression for genes affiliated with Male Breast Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Male Breast Cancer

Search GEO for disease gene expression data for Male Breast Cancer.

Pathways for genes affiliated with Male Breast Cancer

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Male Breast Cancer

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Male Breast Cancer according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
18-oxoguanine449.4BRCA2, BRCA1
2daidzein449.4BRCA2, BRCA1
3lycopene44 2410.4BRCA1, BRCA2
4indole-3-carbinol449.4BRCA2, BRCA1
5methylmethanesulfonate449.3BRCA2, BRCA1
64-hydroxytamoxifen449.3BRCA1, BRCA2
7bleomycin44 1110.3BRCA2, BRCA1
8adpribose449.3BRCA2, BRCA1
9hydroxyurea44 49 1111.3BRCA1, BRCA2
10mitomycin c449.3BRCA2, BRCA1
11p003449.3BRCA1, BRCA2
12vincristine44 49 1111.3BRCA2, BRCA1
13p002449.2BRCA2, BRCA1
14resveratrol44 59 11 2412.2BRCA1, BRCA2
15docetaxel44 49 59 1112.2BRCA2, BRCA1
16gold449.1BRCA1, BRCA2
17camptothecin44 59 1111.1BRCA2, BRCA1
18folate449.0BRCA2, BRCA1
19etoposide44 49 59 1112.0BRCA2, BRCA1
20methotrexate44 49 1110.9BRCA1, BRCA2
21polyacrylamide448.7BRCA2, BRCA1

GO Terms for genes affiliated with Male Breast Cancer

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16Gene Ontology
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Cellular components related to Male Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.0BRCA2, BRCA1

Biological processes related to Male Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of transcription from RNA polymerase II promoterGO:0063579.1BRIP1, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069788.9BRCA2, BRCA1
3double-strand break repair via homologous recombinationGO:0007248.7BRCA2, BRCA1
4double-strand break repairGO:0063028.5BRIP1, BRCA2, BRCA1

Products for genes affiliated with Male Breast Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Male Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet