MCID: MLB002
MIFTS: 54

Male Breast Cancer malady

Cancer diseases category

Summaries for Male Breast Cancer

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Although breast cancer is much more common in women, men can get it too. it happens most often to men between the ages of 60 and 70. breast lumps usually aren't cancer. however, most men with breast cancer have lumps. other breast symptoms can include dimpled or puckered skin a red, scaly nipple or skin fluid discharge risk factors for male breast cancer include exposure to radiation, a family history of breast cancer, and having high estrogen levels, which can happen with diseases like cirrhosis or klinefelter's syndrome. treatment for male breast cancer is usually a mastectomy, which is surgery to remove the breast. other treatments include radiation, chemotherapy and/or hormone therapy. nih: national cancer institute

MalaCards: Male Breast Cancer, also known as male breast carcinoma, is related to breast cancer and bilateral breast cancer. An important gene associated with Male Breast Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Integrated Breast Cancer Pathway and Meiotic Synapsis. The compounds 8-oxoguanine and daidzein have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and prostate.

Wikipedia:63 Male breast cancer (male breast neoplasm) is a relatively rare cancer in men that originates from the... more...

Description from OMIM:46 114480

Aliases & Classifications for Male Breast Cancer

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 22GTR, 46OMIM, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

male breast cancer 8 42 33
male breast carcinoma 42 22
breast cancer, male 42 46
malignant neoplasm of male breast 8
carcinoma of male breast 60
neoplasm of male breast 8
breast male carcinoma 44
breast cancer in men 42


External Ids:

Disease Ontology8 DOID:1614
SNOMED-CT56 126937006
ICD9CM27 175.9

Related Diseases for Male Breast Cancer

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Male Breast Cancer:



Diseases related to male breast cancer

Clinical Features for Male Breast Cancer

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46OMIM
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Clinical features from OMIM:

114480

Drugs & Therapeutics for Male Breast Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Male Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Male Breast Cancer

Search NIH Clinical Center for Male Breast Cancer

Search CenterWatch for Male Breast Cancer

Genetic Tests for Male Breast Cancer

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Sources:
22GTR
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Genetic tests related to Male Breast Cancer:

id Genetic test Affiliating Genes
1 Carcinoma of Male Breast22

Anatomical Context for Male Breast Cancer

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32MalaCards
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MalaCards organs/tissues related to Male Breast Cancer:

32
Breast, Skin, Prostate, Lymph node, Lung, Pituitary, Thyroid, Brain, Testes, Spinal cord

Animal Models for Male Breast Cancer or affiliated genes

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Publications for Male Breast Cancer

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50PubMed
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Articles related to Male Breast Cancer:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Synchronous bilateral breast cancer in a male. (24319497)
2013
2
Electromagnetic field exposure and male breast cancer risk: a meta-analysis of 18 studies. (23534787)
2013
3
Poorer survival of male breast cancer compared with female breast cancer patients may be due to biological differences. (23935206)
2013
4
Two cases of male breast cancer at a university hospital in southeast Brazil. (23825930)
2013
5
SULT1A1 gene deletion in BRCA2-associated male breast cancer: a link between genes and environmental exposures? (23711090)
2013
6
Promoter hypermethylation in male breast cancer: analysis by multiplex ligation-dependent probe amplification. (22765268)
2012
7
Physical and mental health status and health behaviors in male breast cancer survivors: a national, population-based, case-control study. (21695746)
2012
8
Incidence and outcome of male breast cancer: an international population-based study. (21969512)
2011
9
Fulvestrant for advanced male breast cancer patients: a case series. (21447621)
2011
10
High-resolution genomic profiling of male breast cancer reveals differences hidden behind the similarities with female breast cancer. (21113657)
2011
11
Breast cancer incidence in adolescent males undergoing subcutaneous mastectomy for gynecomastia: is pathologic examination justified? A retrospective and literature review. (20871489)
2011
12
Male breast cancer: a report of 127 cases at a Moroccan institution. (21714875)
2011
13
Male breast cancer: management and follow-up recommendations. (21883641)
2011
14
Mutation analysis of BRIP1 in male breast cancer cases: a population-based study in Central Italy. (21165771)
2011
15
A pilot study of male breast cancer in the Veterans Affairs healthcare system. (21303329)
2010
16
Male breast cancer. Evolution of treatment and prognostic factors. Analysis of 489 cases. (19442535)
2010
17
Presence of intranuclear cytoplasmic inclusions and cytoplasmic eosinophilic granules diagnosed by fine needle aspiration cytology in male breast cancer. (19021199)
2009
18
Male breast cancer: a retrospective analysis. (19250851)
2009
19
Male breast cancer: 6-year experience. (18427439)
2008
20
Male breast cancer: it's time for evidence instead of extrapolation. (18854647)
2008
21
Male breast cancer: a different disease than female breast cancer? (17330691)
2007
22
Male breast cancer in a young patient treated with nipple-sparing mastectomy: case report and review of the literature. (17455885)
2007
23
Phenotypic features and genetic characterization of male breast cancer families: identification of two recurrent BRCA2 mutations in north-east of Italy. (16764716)
2006
24
Steroid hormone receptor expression in male breast cancer. (16260112)
2006
25
A cluster of male breast cancer in office workers. (15202128)
2004
26
Male breast cancer: a special therapeutic problem. Anything new? (Review). (14767551)
2004
27
Gelatinase levels in male and female breast cancer. (11890687)
2002
28
Male breast cancer. A report of 71 cases. (12504771)
2002
29
High detection rate for BRCA2 mutations in male breast cancer families from North West England. (14574168)
2001
30
Clinical relevance of biologic factors in male breast cancer. (11727961)
2001
31
Male breast cancer with maxillofacial metastasis: case report. (11326390)
2001
32
Karyotypic findings in two cases of male breast cancer. (11063806)
2000
33
Male breast cancer: risk to daughters. (10210008)
1999
34
Male breast cancer in patients with a familial history of breast cancer. (9017958)
1996
35
Male breast cancer. (8873325)
1996
36
Mutations of the p53 gene in male breast cancer. (7712430)
1995
37
Treatment of locally recurrent male breast cancer by regional chemotherapy. (7749694)
1995
38
Male breast cancer--a report of 4 cases and a review of the literature. (7649518)
1995
39
Breast cancer in a male patient with prolactinoma. (8385514)
1993
40
Immunocytochemical characterization of male breast cancer. (1369797)
1992
41
Male breast cancer. (1775819)
1991
42
Male breast cancer--a 20-year review of 16 cases at Yonsei University. (2177938)
1990
43
Role of adjuvant chemotherapy in male breast cancer. (2676137)
1989
44
Estrogen receptors in male breast cancer: clinical and pathologic correlations. (6257370)
1981
45
Tamoxifen in advanced male breast cancer. (435005)
1979
46
Tamoxifen and male breast cancer. (79956)
1978
47
Male breast cancer. (4414549)
1974
48
Male breast cancer. 6. Factors influencing prognosis. (4451631)
1974
49
Male breast cancer. 3. Breast carcinoma in association with the Klinefelter syndrome. (4767227)
1973
50
Male breast cancer; Klinefelter syndrome with prostatic, adrenal and mammary tumors. (14370607)
1955

Genetic Variations for Male Breast Cancer

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Sources:
62UniProtKB/Swiss-Prot
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Genetic disease variations for Male Breast Cancer:

62 (show all 70)
id Symbol AA change Variation ID SNP ID
1AKT1p.Glu17LysVAR_055422rs121434592
2BRCA1p.Leu22SerVAR_007756
3BRCA1p.Cys61GlyVAR_007757rs28897672
4BRCA1p.Cys64GlyVAR_007758
5BRCA1p.Val271MetVAR_007761rs80357244
6BRCA1p.Phe461LeuVAR_007765rs56046357
7BRCA1p.Tyr465AspVAR_007766
8BRCA1p.Gly552ValVAR_007768
9BRCA1p.Leu892SerVAR_007775
10BRCA1p.Gly960AspVAR_007776
11BRCA1p.Thr1025IleVAR_007778
12BRCA1p.Val1047AlaVAR_007781
13BRCA1p.Pro1150SerVAR_007782rs80357272
14BRCA1p.Ala1708GluVAR_007796rs28897696
15BRCA1p.Met1775ArgVAR_007799
16BRCA1p.Glu10LysVAR_020679
17BRCA1p.Glu23LysVAR_020680
18BRCA1p.Asp749TyrVAR_020683
19BRCA1p.Ser1187IleVAR_020690
20BRCA1p.Gln1200HisVAR_020691rs56214134
21BRCA1p.Arg1204IleVAR_020692
22BRCA1p.Lys1207AsnVAR_020693
23BRCA1p.Ser1217TyrVAR_020695
24BRCA1p.Arg1699TrpVAR_020703
25BRCA1p.Met1775LysVAR_063212
26BRCA2p.Phe32LeuVAR_005085
27BRCA2p.Lys53ArgVAR_005086
28BRCA2p.Phe81LeuVAR_005088
29BRCA2p.Pro201ArgVAR_005089
30BRCA2p.Val211AlaVAR_005090
31BRCA2p.Pro222SerVAR_005091
32BRCA2p.Cys554TrpVAR_005095
33BRCA2p.Asp728AlaVAR_005097
34BRCA2p.Gly2274ValVAR_005105
35BRCA2p.His2415AsnVAR_005106
36BRCA2p.Gln2421HisVAR_005107
37BRCA2p.Met3118ThrVAR_005110
38BRCA2p.Thr3357ArgVAR_005111
39BRCA2p.Glu2089AspVAR_008783
40BRCA2p.Thr2722ArgVAR_018661
41BRCA2p.Ser1179AsnVAR_020715
42BRCA2p.Cys1580TyrVAR_020719
43BRCA2p.Thr1679IleVAR_020720
44BRCA2p.Val1804AlaVAR_020721
45BRCA2p.Glu1901LysVAR_020722
46BRCA2p.Ser2072CysVAR_020725
47BRCA2p.Tyr2094CysVAR_020726
48BRCA2p.Pro2096LeuVAR_020727
49BRCA2p.Lys2128AsnVAR_020729
50BRCA2p.Val2728IleVAR_020736rs28897749
51BRCA2p.Lys2729AsnVAR_020737rs80359065
52BRCA2p.Asn3124IleVAR_020743
53BRCA2p.Lys3196GluVAR_020744rs80359228
54BRCA2p.Gly25ArgVAR_028167
55BRCA2p.Trp31CysVAR_028168
56BRCA2p.Trp31ArgVAR_028169
57BRCA2p.Thr64IleVAR_032712
58BRCA2p.Ser326ArgVAR_032717rs28897706
59BRCA2p.Ile505ThrVAR_032718rs28897708
60BRCA2p.Ile729MetVAR_032719
61BRCA2p.Lys1690AsnVAR_032722
62BRCA2p.Asn1730TyrVAR_032723
63BRCA2p.Thr1887MetVAR_032724
64BRCA2p.Asn2135HisVAR_032728
65BRCA2p.Tyr2222CysVAR_032729
66BRCA2p.Gln2456GluVAR_032731
67BRIP1p.Pro47AlaVAR_020896rs28903098
68BRIP1p.Met299IleVAR_020900
69NBNp.Leu150PheVAR_025795
70RAD51p.Arg150GlnVAR_010899rs121917739

Expression for genes affiliated with Male Breast Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Male Breast Cancer

Search GEO for disease gene expression data for Male Breast Cancer.

Pathways for genes affiliated with Male Breast Cancer

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Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG, 12EMD Millipore, 4Cell Signaling Technology
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Compounds for genes affiliated with Male Breast Cancer

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Male Breast Cancer according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
18-oxoguanine449.4BRCA2, BRCA1
2daidzein449.4BRCA2, BRCA1
3lycopene44 2410.4BRCA1, BRCA2
4indole-3-carbinol449.4BRCA2, BRCA1
5methylmethanesulfonate449.3BRCA2, BRCA1
64-hydroxytamoxifen449.3BRCA1, BRCA2
7bleomycin44 1110.3BRCA2, BRCA1
8adpribose449.3BRCA2, BRCA1
9hydroxyurea44 49 1111.3BRCA1, BRCA2
10mitomycin c449.3BRCA2, BRCA1
11p003449.3BRCA1, BRCA2
12vincristine44 49 1111.3BRCA2, BRCA1
13p002449.2BRCA2, BRCA1
14resveratrol44 59 11 2412.2BRCA1, BRCA2
15docetaxel44 49 59 1112.2BRCA2, BRCA1
16gold449.1BRCA1, BRCA2
17camptothecin44 59 1111.1BRCA2, BRCA1
18folate449.0BRCA2, BRCA1
19etoposide44 49 59 1112.0BRCA2, BRCA1
20methotrexate44 49 1110.9BRCA1, BRCA2
21polyacrylamide448.7BRCA2, BRCA1

GO Terms for genes affiliated with Male Breast Cancer

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16Gene Ontology
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Cellular components related to Male Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432349.0BRCA2, BRCA1

Biological processes related to Male Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of transcription from RNA polymerase II promoterGO:0063579.1BRIP1, BRCA1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:0069788.9BRCA2, BRCA1
3double-strand break repair via homologous recombinationGO:0007248.7BRCA2, BRCA1
4double-strand break repairGO:0063028.5BRIP1, BRCA2, BRCA1

Products for genes affiliated with Male Breast Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Male Breast Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet