MCID: MLB002
MIFTS: 56

Male Breast Cancer malady

Cancer category

Summaries for Male Breast Cancer

Sources:
34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Although breast cancer is much more common in women, men can get it too. it happens most often to men between the ages of 60 and 70. breast lumps usually aren't cancer. however, most men with breast cancer have lumps. other breast symptoms can include dimpled or puckered skin a red, scaly nipple or skin fluid discharge risk factors for male breast cancer include exposure to radiation, a family history of breast cancer, and having high estrogen levels, which can happen with diseases like cirrhosis or klinefelter's syndrome. treatment for male breast cancer is usually a mastectomy, which is surgery to remove the breast. other treatments include radiation, chemotherapy and/or hormone therapy. nih: national cancer institute

MalaCards: Male Breast Cancer, also known as male breast carcinoma, is related to bilateral breast cancer and gynecomastia. An important gene associated with Male Breast Cancer is BRCA2 (breast cancer 2, early onset), and among its related pathways are Nucleotide Excision Repair and DNA damage DNA-damage-induced responses. The compounds estrogen and adriamycin have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and spinal cord, and related mouse phenotypes are endocrine/exocrine gland and tumorigenesis.

Wikipedia:64 Male breast cancer is a relatively rare cancer in men that originates from the breast. As it presents a... more...

Description from OMIM:47 114480

Aliases & Classifications for Male Breast Cancer

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 47OMIM, 22GTR, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

male breast cancer 8 43 34
male breast carcinoma 43 22
breast cancer, male 43 47
malignant neoplasm of male breast 8
carcinoma of male breast 61
neoplasm of male breast 8
breast male carcinoma 45
breast cancer in men 43


External Ids:

Disease Ontology8 DOID:1614
SNOMED-CT57 126937006
ICD9CM27 175.9

Related Diseases for Male Breast Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Male Breast Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1bilateral breast cancer30.8PGR, CHEK2, BRCA1, BRCA2
2gynecomastia30.5BRCA2, BRCA1, APOD, AR, CYP17A1, PGR
3hyperprolactinemia30.1SRD5A1
4papillary carcinoma30.1NME1, BRCA2, PGR, LGALS1
5thyroid cancer30.1NME1, LGALS1, CTSD
6colorectal cancer30.1HFE, NME1, SERPINB2, LGALS1, CTSD
7bladder carcinoma30.1SERPINB2
8adenoma30.1BRCA1, CTSD, HFE, SRD5A1, LGALS1, ACPP
9familial breast cancer10.6
10klinefelter's syndrome10.4
11sporadic breast cancer10.3
12mandibular cancer10.2
13breast lymphoma10.2
14testicular cancer10.2
15breast cancer, somatic10.2
16female breast carcinoma10.2
17breast reconstruction10.1
18estrogen-receptor positive breast cancer10.1
19progesterone-receptor positive breast cancer10.1
20acute t cell leukemia10.1
21breast apocrine carcinoma10.1
22oncocytic breast carcinoma10.1
23n syndrome10.1
24acute leukemia10.1
25brain cancer10.1
26breast adenoma10.1
27spinal cancer10.1
28t-cell leukemia10.1
29oral cancer10.1
30hypoxia10.1
31paraneoplastic syndromes10.1
32choroid cancer10.1
33pilomatrixoma10.1
34neuroendocrine carcinoma10.1
35synchronous bilateral breast carcinoma10.1
36breast papillary carcinoma10.1
37pancreatitis10.0BRCA2
38breast-ovarian cancer, familial, 210.0BRCA2
39infertility10.0AR
40hepatitis10.0HFE
41multiple endocrine neoplasia10.0BRCA2
42neuroblastoma10.0NME1
43schizophrenia10.0APOD
44brca1 and brca2 hereditary breast and ovarian cancer10.0BRCA1, BRCA2
45astrocytoma10.0APOD, BRCA1
46peritoneal carcinoma10.0BRCA1, BRCA2
47wilms tumor10.0BRCA2, SRD5A1
48meningioma10.0PGR, CTSD
49prostatic hypertrophy10.0AR, ACPP
50myeloid leukemia10.0NME1

Graphical network of the top 20 diseases related to Male Breast Cancer:



Diseases related to male breast cancer

Clinical Features for Male Breast Cancer

Sources:
47OMIM
See all sources

Clinical features from OMIM:

114480

Drugs & Therapeutics for Male Breast Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Male Breast Cancer

Drug clinical trials:

Search ClinicalTrials for Male Breast Cancer

Search NIH Clinical Center for Male Breast Cancer

Search CenterWatch for Male Breast Cancer

Genetic Tests for Male Breast Cancer

Sources:
22GTR
See all sources

Genetic tests related to Male Breast Cancer:

id Genetic test Affiliating Genes
1 Carcinoma Of Male Breast22

Anatomical Context for Male Breast Cancer

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Male Breast Cancer:

33
Lymph node, Brain, Spinal cord, Lung, Thyroid, Adrenal gland, Breast, Skin, Prostate, Pituitary

Animal Models for Male Breast Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Male Breast Cancer

Sources:
51PubMed
See all sources

Articles related to Male Breast Cancer:

(show top 50)    (show all 532)
idTitleAuthorsYear
1
Fulvestrant and male breast cancer: a case series. (23251011)
2013
2
Management and outcomes of male breast cancer in zaria, Nigeria. (22991670)
2012
3
Re: Imaging male breast cancer. (22300819)
2012
4
Mandibular metastases as first clinical sign of an occult male breast cancer. (22446070)
2012
5
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk. (23001122)
2012
6
Health-related quality of life in male breast cancer patients. (22315132)
2012
7
Circulating tumor cells count and characterization in a male breast cancer patient. (21725206)
2011
8
Rare case of male breast cancer and axillary lymphoma in the same patient: an unique case report. (22007238)
2011
9
PALB2 mutations in male breast cancer: a population-based study in Central Italy. (20180015)
2010
10
Gene copy number variation in male breast cancer by aCGH. (21045282)
2010
11
Contralateral male breast cancer with a positive family history - a case report with review of literature. (23133209)
2010
12
Incidence of prostate cancer in male breast cancer patients: a risk factor for prostate cancer screening. (18504455)
2009
13
Awareness is the key to conquering male breast cancer. (19487998)
2009
14
Male breast cancer: 22 case reports at the National Hospital of Niamey-Niger (West Africa). (21532724)
2009
15
Male breast cancer 15 years after allogeneic hematopoietic cell transplantation including total body irradiation for recurrent acute lymphoblastic leukemia. (18497517)
2008
16
BRCA1/BRCA2 rearrangements and CHEK2 common mutations are infrequent in Italian male breast cancer cases. (17661168)
2008
17
Synchronous male breast cancer and carcinoma of prostate in 90-year-old male, presented with spinal cord compression and multiple spine lytic lesions. (17593047)
2007
18
Systemic therapy of male breast cancer]. (17907081)
2007
19
Diagnosis and management of male breast cancer in the community hospital setting. (16509854)
2006
20
Male breast cancer: is the incidence increasing? (15289238)
2004
21
Significant contribution of germline BRCA2 rearrangements in male breast cancer families. (15548676)
2004
22
CHEK2 1100delC is not a risk factor for male breast cancer population. (14648717)
2004
23
Complete nodal staging in male breast cancer. (Biopsy of axillary and internal mammary sentinel node). (15149167)
2004
24
Androgen receptor gene alterations in Finnish male breast cancer. (12602915)
2003
25
BRCA1 and BRCA2 mutation status and tumor characteristics in male breast cancer: a population-based study in Italy. (12543786)
2003
26
Recognizing features that are dissimilar in male and female breast cancer: expression of p21Waf1 and p27Kip1 using an immunohistochemical assay. (12123335)
2002
27
Epidemiology of male breast cancer. (12195156)
2002
28
Pharmacotherapy for male breast cancer. (12036409)
2002
29
How I do it--biopsy of axillary and internal mammary sentinel node for complete nodal staging in male breast cancer. (12217311)
2002
30
Risk factors for male breast cancer in Canada, 1994-1998. (12131659)
2002
31
Two-step approach for the operation of male breast cancer: report of a case at high risk for surgery. (10352495)
1998
32
Male breast cancer: a 22-year experience. (9870732)
1998
33
A case of brain metastases from male breast cancer responding to tamoxifen. (9470820)
1997
34
Linkage to BRCA2 region in hereditary male breast cancer. (7658781)
1995
35
Mammary tumour induction by pituitary grafting in male mice: an animal model for male breast cancer. (8277709)
1993
36
Male breast cancer. (8435670)
1993
37
Current management of male breast cancer. A review of 104 cases. (1319699)
1992
38
Expression of prognostic factors (EGFR, ER) by immunohistochemical staining method in male breast cancer. (1949915)
1991
39
Electromagnetic fields and male breast cancer. (1979420)
1990
40
Risk factors for male breast cancer: a Franco-Swiss case-control study. (2323842)
1990
41
Nasally administered buserelin inducing complete remission of lung metastases in male breast cancer. (3100015)
1987
42
Familial breast cancer in males. A case report and review of the literature. (3779619)
1986
43
Male breast cancer from pacemaker pocket. (2414760)
1985
44
Male breast cancer following repeated fluoroscopy. (6326571)
1984
45
Cytoplasmic and nuclear estrogen and progesterone receptors in male breast cancer. (7127316)
1982
46
Bilateral breast cancer in a Chinese male. (6274288)
1981
47
The role of orchiectomy in the management of advanced male breast cancer. (1253122)
1976
48
Familial male breast cancer. (54567)
1976
49
Letter: Tumor-associated antigen in female and male breast cancer. (1109190)
1975
50
MALE BREAST CANCER IN KLINEFELTER'S SYNDROME. (14238690)
1965

Genetic Variations for Male Breast Cancer

Expression for genes affiliated with Male Breast Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Male Breast Cancer

Search GEO for disease gene expression data for Male Breast Cancer.

Pathways for genes affiliated with Male Breast Cancer

Sources:
54Reactome, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG, 52QIAGEN
See all sources

Pathways related to Male Breast Cancer according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3BRCA2, PALB2
210.3BRCA1, CHEK2
3
Hide members
10.2SRD5A1, CYP17A1
410.2BRCA1, BRCA2, PALB2
5
DNA damage Role of Brca1 and Brca2 in DNA repair
Hide members
10.2BRCA2, BRCA1, CHEK2
610.2CHEK2, BRCA2, BRCA1
710.1BRCA1, AR, PRDX1
810.1BRCA1, PRDX1, AR
910.1BRCA1, BRCA2, CHEK2, AR
10
Hide members
10.1BRCA1, AR, CYP17A1, CHEK2
119.9BRCA2, NME1, CHEK2, AR, BRCA1

Compounds for genes affiliated with Male Breast Cancer

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Male Breast Cancer according to GeneCards/GeneDecks:

(show top 50)    (show all 111)
idCompoundScoreTop Affiliating Genes
1estrogen4510.6SRD5A1, ACPP
2adriamycin4510.5PGR, CHEK2, CTSD
3cycloheximide4510.5BRCA1, SERPINB2, BRCA2
4dehydroepiandrosterone sulfate4510.5ACPP, SRD5A1
5goserelin45 29 1112.5SRD5A1, ACPP
6chlormadinone acetate4510.5AR, PGR, ACPP
7norgestimate45 1111.4SRD5A1, PGR, AR
8nilutamide45 60 29 1113.4AR, PGR, ACPP
9exemestane50 45 60 1113.4PGR, SRD5A1, AR, CYP17A1
10bisphenol a4510.3AR, CYP17A1, PGR
114-hydroxytamoxifen4510.3BRCA1, PGR, BRCA2, CTSD
12diethylstilbestrol45 29 1112.3ACPP, AR, PGR, CYP17A1
13cyproteroneacetate4510.3ACPP, SRD5A1, PGR, AR
14finasteride45 60 11 2413.3SRD5A1, ACPP, AR
153beta-hydroxysteroid4510.3PGR, SRD5A1, CYP17A1, AR
16flutamide45 60 1112.3AR, PGR, ACPP, SRD5A1
1717beta-hydroxysteroid4510.3BRCA1, CYP17A1, PGR, SRD5A1, AR
18steroidal4510.3SRD5A1, PGR, CYP17A1, CTSD, AR
19dhea4510.2SRD5A1, CYP17A1, ACPP, AR
20dexamethasone45 50 29 1113.2SERPINB2, LGALS1, NME1, CYP17A1, AR
21agarose4510.2BRCA1, APOD, CTSD, LGALS1, HFE
22serine4510.2PRDX1, NME1, BRCA1, CHEK2, ACPP
23boldenone45 1111.2AR, SRD5A1
24androstenedione45 2411.2ACPP, SRD5A1, CYP17A1, AR
25progestin4510.1CTSD, NME1, PGR, SRD5A1, AR, CYP17A1
26tamoxifen45 50 29 1113.1AR, CYP17A1, PGR, APOD, BRCA2, BRCA1
27dihydrotestosterone45 29 11 2413.1SRD5A1, ACPP, PGR, CYP17A1, AR, APOD
28doxorubicin45 50 1112.1PRDX1, BRCA1, CTSD, AR, CHEK2, PGR
29gnrh4510.1AR, SRD5A1, CYP17A1, ACPP, PGR
30matrigel4510.0SERPINB2, LGALS1, NME1, AR, BRCA2
31cisplatin45 50 60 1113.0BRCA1, ACPP, CTSD, BRCA2, CHEK2, NME1
32agar4510.0LGALS1, ACPP, NME1, PGR, AR, CTSD
33thymidine45 2411.0CYP17A1, BRCA1, CTSD, NME1, ACPP, BRCA2
34genistein45 29 60 2 11 2415.0AR, BRCA1, SRD5A1, PGR, CYP17A1, CHEK2
35etoposide45 50 60 1113.0BRCA1, CTSD, BRCA2, AR, LGALS1, CHEK2
36oligonucleotide4510.0BRCA1, BRCA2, APOD, HFE, CHEK2, CYP17A1
37histidine459.9NME1, CYP17A1, HFE, CTSD, LGALS1
38estradiol45 11 2411.9AR, BRCA1, CTSD, CYP17A1, PGR, ACPP
39glutamine459.9PGR, SRD5A1, CTSD, BRCA2, BRCA1, AR
40aspartate459.9HFE, ACPP, CTSD, AR, PGR, NME1
41estrone45 29 11 2412.9PGR, SRD5A1, AR, CYP17A1
42vegf459.8ACPP, SRD5A1, PGR, AR, CTSD, BRCA1
43p003459.7BRCA2, BRCA1, CTSD, HFE
44alanine459.7CTSD, BRCA1, HFE, CHEK2, PGR, NME1
45testosterone45 60 11 2412.7HFE, PGR, ACPP, SRD5A1, CYP17A1, AR
46paraffin459.7NME1, ACPP, LGALS1, SERPINB2, PGR, AR
47steroid459.7SRD5A1, EREG, SERPINB2, ACPP, NME1, CYP17A1
48retinoic acid45 2410.6AR, PGR, BRCA2, CTSD, BRCA1, CHEK2
49progesterone45 60 29 11 2413.4CTSD, AR, CYP17A1, PGR, NME1, ACPP
50tyrosine459.3BRCA1, HFE, NME1, ACPP, CHEK2, EREG

GO Terms for genes affiliated with Male Breast Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Male Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleoplasmGO:0056549.8PALB2, PGR, CHEK2, AR, BRCA2, BRCA1

Biological processes related to Male Breast Cancer according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1tertiary branching involved in mammary gland duct morphogenesisGO:06074810.4PGR, AR
2ovulationGO:03072810.3CYP17A1, EREG
3double-strand break repairGO:00630210.3BRCA2, BRCA1, CHEK2
4double-strand break repair via homologous recombinationGO:00072410.3PALB2, SHFM1, BRCA2, BRCA1
5sex differentiationGO:00754810.3AR, CYP17A1, SRD5A1
6androgen biosynthetic processGO:00670210.3CYP17A1, SRD5A1
7oocyte maturationGO:00155610.3BRCA2, EREG
8hormone biosynthetic processGO:04244610.2CYP17A1, HFE
9inner cell mass cell proliferationGO:00183310.2BRCA2, PALB2
10DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.0BRCA1, BRCA2

Molecular functions related to Male Breast Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.7LGALS1, BRCA2, EXOSC8, APOD, CTSD, AR

Products for genes affiliated with Male Breast Cancer

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Sources for Male Breast Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet