Male Germ Cell Tumor malady

MalaCards: Male Germ Cell Tumor is related to seminoma and germ cell tumor. An important gene associated with Male Germ Cell Tumor is MGCT (male germ cell tumor), and among its related pathways are Breast Cancer Regulation by Stathmin1 and Cell cycle_Regulation of G1/S transition (part 2). The compounds roscovitine and h2o2 have been mentioned in the context of this disorder. Related mouse phenotypes are craniofacial and liver/biliary system.

male germ cell tumor 7 33 43

Diseases related to male germ cell tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 242)

id	Related Disease	Score	Top Affiliating Genes
1	seminoma	25.6	KIT, RASSF1, ZFP42, CGB5, CDK2, MGMT
2	germ cell tumor	23.6	KIT, BMP2, RASSF1, ZFP42, CGB5, CDKN1A
3	bladder cancer, somatic	13.3	FGFR3, HRAS
4	synostosis	13.2	BMP2, FGF4, FGFR3
5	hyperpigmentation of eyelid	13.1	KIT, FGFR3, STK11
6	sertoli cell tumor	13.1	KIT, CGB5, STK11
7	pleomorphic liposarcoma	13.1	KIT, MDM2
8	penile cancer	13.0	CDKN2A, HRAS
9	testicular neoplasm	12.9	KIT, FGFR3, STK10, STK11
10	craniosynostosis	12.9	BMP2, FGF4, FGFR3, HRAS
11	pleomorphic adenoma	12.8	BMP2, MDM2, HRAS
12	germinoma	12.8	KIT, CGB5, DMRT1
13	dysgerminoma	12.7	KIT, CGB5, DMRT1
14	synovial sarcoma	12.7	KIT, RASSF1, MDM2
15	malignant peripheral nerve sheath tumor	12.6	KIT, CDKN2A, MDM2
16	burkitt's lymphoma	12.6	RASSF1, MDM2, CCNA2, CCND2
17	spitz nevus	12.6	HRAS, TP53
18	large cell carcinoma	12.6	CGB5, TP53, STK11
19	pediatric cns embryonal cell carcinoma	12.6	KIT, BMP2, CGB5, FGF4, CCNA2, CCND2
20	anal squamous cell carcinoma	12.5	MDM2, TP53
21	skin benign neoplasm	12.5	MGMT, FGFR3, HRAS
22	bladder transitional cell papilloma	12.5	CDKN1A, FGFR3, TP53
23	pleomorphic adenoma carcinoma	12.5	CDKN2A, CCNA2, TP53
24	teratocarcinoma	12.5	BMP2, ZFP42, CDKN1A, FGF4, MDM2
25	bullous keratopathy	12.5	BMP2, CDKN1A, TP53
26	hemangioma of lung	12.5	CDKN2A, TP53, STK11
27	acute promyelocytic leukemia	12.4	BMP2, CDKN1A, CDK1, CCNA1, HRAS
28	invasive bladder transitional cell carcinoma	12.4	CDKN1A, TP53
29	familial pancreatic cancer	12.4	CDKN2A, TP53, STK11
30	nasopharynx carcinoma	12.4	RASSF1, CDKN2A, TP53
31	familial melanoma	12.4	CDKN2A, MGMT, MDM2
32	acute lymphoblastic leukemia, childhood	12.4	CDK2, CDKN2A, MDM2, CCNA2
33	adult medulloblastoma	12.4	MDM2, TP53
34	cervical endometrioid adenocarcinoma	12.3	CDKN2A, CCNA2, TP53
35	uterine sarcoma	12.3	KIT, CDK2, CDKN2A, MDM2
36	esophagus adenocarcinoma	12.3	CDKN1A, CDKN2A, TP53
37	embryonal sarcoma	12.3	KIT, MDM2, TP53
38	cystic teratoma	12.3	KIT, CDKN2A, TP53
39	benign meningioma	12.3	MDM2, CCNA2, TP53
40	brain glioma	12.3	BMP2, CDKN2A, TP53
41	uterine carcinosarcoma	12.3	KIT, CDKN2A, TP53
42	benign tumors	12.3	RASSF1, CGB5, TP53, STK11
43	sclerosing hemangioma	12.3	CDKN2A, TP53, STK11
44	recurrent respiratory papillomatosis	12.3	CDKN1A, CDKN2A, TP53
45	pancreatic ductal carcinoma	12.3	CDK2, CDKN2A, TP53
46	germ cell cancer	12.2	CDKN2A, FGF4, HRAS, TP53
47	thyroid lymphoma	12.2	CDKN2A, CDK1, CCNA2, TP53
48	chronic lymphocytic leukemia	12.2	CDK2, CDK1, MDM2, APAF1, CCNA2, CCND2
49	adenosquamous carcinoma	12.2	KIT, CDKN2A, TP53
50	adult astrocytic tumour	12.2	CDKN2A, MDM2, TP53

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to male germ cell tumor:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial phenotype	MP:0005382	9.8	KIT, APAF1, STK11, HIC1
2	liver/biliary system phenotype	MP:0005370	9.5	CCND2, KIT, TP53
3	normal phenotype	MP:0002873	9.0	CDK1, APAF1, HRAS, HIC1, STK11, FGF4
4	limbs/digits/tail phenotype	MP:0005371	7.6	BMP2, CDKN1A, KIT, FGFR3, MDM2, APAF1
5	vision/eye phenotype	MP:0005391	7.2	CDKN1A, CDK2, CDKN2A, FGFR3, APAF1, CCND2
6	digestive/alimentary phenotype	MP:0005381	6.9	FGFR3, TP53, HIC1, STK11, CDKN2A, CDKN1A
7	skeleton phenotype	MP:0005390	6.6	HIC1, HRAS, MDM2, FGFR3, FGF4, APAF1
8	integument phenotype	MP:0010771	6.6	CDKN2A, KIT, FGFR3, MDM2, HRAS, TP53
9	embryogenesis phenotype	MP:0005380	6.4	KIT, APAF1, CDKN1A, BMP2, STK11, CCNA2
10	cardiovascular system phenotype	MP:0005385	6.4	HRAS, TP53, STK11, APAF1, MDM2, CDK2
11	hematopoietic system phenotype	MP:0005397	6.3	CCNA2, KIT, STK11, TP53, CCNA1, CCND2
12	mortality/aging	MP:0010768	6.0	FGFR3, BMP2, FGF4, MGMT, CDK1, CDKN1A
13	immune system phenotype	MP:0005387	5.8	STK11, RASSF1, CDKN1A, CDK2, CDKN2A, FGFR3
14	tumorigenesis	MP:0002006	5.3	APAF1, TP53, HIC1, STK11, MDM2, FGFR3
15	cellular phenotype	MP:0005384	5.3	CDKN2A, DMAP1, BMP2, RASSF1, ZFP42, CDK2
16	homeostasis/metabolism phenotype	MP:0005376	5.2	RASSF1, STK11, HRAS, KIT, MGMT, CCND2
17	endocrine/exocrine gland phenotype	MP:0005379	INF	, CCNA1, APAF1, ZFP42
18	reproductive system phenotype	MP:0005389	INF	STK11, CDK1, DMAP1, APAF1, , HRAS

Articles related to male germ cell tumor:

(show all 15)

id	Title	Authors	Year	Affiliating Genes
1	Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors. (18622385)	Netto G.J.... De Marzo A.M.	2008	DMAP1
2	Kit expression in male germ cell tumors. (17595797)	Nikolaou M.... Pectasides D.	2007	KIT
3	Determination of hyperglycosylated human chorionic gonadotropin produced by malignant gestational trophoblastic neoplasias and male germ cell tumors using a lectin-based immunoassay and surface plasmon resonance. (17081681)	Kelly L.S.... Puett D.	2007	CGB5
4	Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. (16424014)	Korkola J.E.... Chaganti R.S.	2006	FGF4, ZFP42
5	Analysis of p16INK4A gene promoter in male germ-cell tumors: identification of a new point mutation. (15734211)	Fombonne J.... Krantic S.	2005	CDKN2A
6	Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. (14696091)	Liao C.... Wolgemuth D.J.	2004	CDK2, CCNA2, CCNA1
7	Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors. (15149548)	Koul S.... Murty V.V.	2004	MGMT, RASSF1, HIC1
8	The human SPANX multigene family: genomic organization, alignment and expression in male germ cells and tumor cell lines. (12758128)	Zendman A.J.... van Muijen G.N.P.	2003	SPANXC, SPANXA1, SPANXA2
9	ID gene expression varies with lineage during differe ntiation of pluripotential male germ cell tumor cell lines. (11320653)	Houldsworth J.... Chaganti R.S.	2001	BMP2
10	Genetic analysis of the APAF1 gene in male germ cell tumors. (10862031)	Bala S.... Murty V.V.	2000	APAF1
11	A genetic perspective of male germ cell tumors. (9562446)	Murty V.V.... Chaganti R.S.	1998	CCND2
12	The cytogenetic theory of the pathogenesis of human adult male germ cell tumors. Review article. (9524565)	Chaganti R.S.... Houldsworth J.	1998	CCND2
13	Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation. (9620551)	Houldsworth J.... Chaganti R.S.	1998	MDM2, TP53, CDKN1A
14	Physical mapping of a commonly deleted region, the site of a candidate tumor suppressor gene, at 12q22 in human male germ cell tumors. (8812492)	Murty V.V.... Chaganti R.S.	1996	MGCT
15	Detection of preferential NRAS mutations in human male germ cell tumors by the polymerase chain reaction. (1964583)	Ganguly S.... Chaganti R.S.	1990	HRAS

Genes related to male germ cell tumor according to GeneCards:

(show all 32)

id	Symbol	Description	Score	GeneCards Section Context
1	MGCT	male germ cell tumor	11.1	Publications, Aliases & Descriptions
2	SPANXF1	SPANX family, member F1	11.0	Publications
3	SPANXE	SPANX family, member E	11.0	Publications
4	SPANXB2	SPANX family, member B2	11.0	Publications
5	SPANXB1	SPANX family, member B1	11.0	Publications
6	SPANXA2	SPANX family, member A2	11.0	Publications
7	SPANXA1	sperm protein associated with the nucleus, X-linked, family member A1	11.0	Publications
8	SPANXD	SPANX family, member D	11.0	Publications
9	SPANXC	SPANX family, member C	11.0	Publications
10	ZFP42	zinc finger protein 42 homolog (mouse)	11.0	Publications
11	HIC1	hypermethylated in cancer 1	11.0	Publications
12	FGF4	fibroblast growth factor 4	11.0	Publications
13	CCNA1	cyclin A1	11.0	Publications
14	CCND2	cyclin D2	11.0	Publications
15	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
16	DMAP1	DNA methyltransferase 1 associated protein 1	11.0	Publications
17	APAF1	apoptotic peptidase activating factor 1	11.0	Publications
18	STK10	serine/threonine kinase 10	11.0
19	STK11	serine/threonine kinase 11	11.0
20	CCNA2	cyclin A2	11.0	Publications
21	BMP2	bone morphogenetic protein 2	11.0	Publications
22	CDK1	cyclin-dependent kinase 1	11.0	Publications
23	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
24	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
25	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
26	FGFR3	fibroblast growth factor receptor 3	11.0
27	CDK2	cyclin-dependent kinase 2	11.0	Publications
28	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications
29	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
30	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
31	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
32	TP53	tumor protein p53	11.0	Publications

Pathways related to male germ cell tumor according to GeneDecks:

(show top 50)    (show all 76)

id	Pathway	Score	Top Affiliating Genes
1	Breast Cancer Regulation by Stathmin136	10.1	BMP2, FGFR3, FGF4
2	Cell cycle_Regulation of G1/S transition (part 2)41	9.8	CCNA2, CCNA1, CCND2, CDK2
3	Cell cycle Regulation of G1/S transition (part 2)10	9.8	CDK2, CCNA2, CCNA1, CCND2
4	Cell cycle_Transition and termination of DNA replication41	9.6	CDK2, CDK1, CCNA2, CCNA1
5	Cell cycle Transition and termination of DNA replacation10	9.6	CCNA1, CDK2, CDK1, CCNA2
6	Cell cycle Cell cycle (generic schema)10	9.6	CDK2, CCNA2, CCND2, CCNA1, CDK1
7	Cell cycle_Cell cycle (generic schema)41	9.5	CDK2, CCND2, CCNA1, CCNA2, CDK1
8	Cell cycle_Role of APC in cell cycle regulation41	9.5	CCNA2, CDK1, CDK2, RASSF1, CCNA1
9	Cell cycle Role of APC in cell cycle regulation10	9.5	CCNA1, CDK1, CDK2, RASSF1, CCNA2
10	Cell cycle ESR1 regulation of G1/S transition10	9.5	CCNA1, CDK2, CDKN1A, CCNA2
11	Cell cycle_ESR1 regulation of G1/S transition41	9.5	CCNA1, CDKN1A, CDK2, CCNA2
12	Apoptosis and survival Role of CDK5 in neuronal death and survival10	9.4	HRAS, CDK1, TP53, APAF1
13	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.4	TP53, APAF1, HRAS, CDK1
14	Transcription P53 signaling pathway10	9.4	CDK2, TP53, CDKN2A
15	Estrogen-mediated S-Phase Entry36	9.3	CCNA1, CDKN1A, CDK2, CCNA2
16	Calpain Protease Regulates Cellular Mechanics36	9.3	CCND2, CCNA1, CDK2, HRAS, CCNA2
17	Non-small cell lung cancer20	9.0	TP53, HRAS, CDKN2A, RASSF1
18	GADD45 Pathway36	8.9	TP53, CCND2, CDK2, CCNA2, CDKN1A, CCNA1
19	Cell cycle Regulation of G1/S transition (part 1)10	8.8	CDKN1A, CCNA1, CCNA2, CDKN2A, CDK2, CCND2
20	Cell cycle_Regulation of G1/S transition (part 1)41	8.8	CDKN2A, CDKN1A, CCNA1, CCND2, CCNA2, CDK2
21	Apoptotic Pathways in Synovial Fibroblasts36	8.7	KIT, BMP2, FGF4, FGFR3, TP53
22	Signal transduction_AKT signaling41	8.7	CDKN1A, CCND2, TP53, MDM2
23	Signal transduction PTEN pathway10	8.7	TP53, HRAS, MDM2, CDKN1A
24	ATM Pathway36	8.7	CDK2, CDKN1A, MDM2, TP53
25	Cell Cycle, Mitotic38	8.6	CDK2, CDKN2A, CCNA2, CCNA1, CDKN1A
26	Chks in Checkpoint Regulation36	8.6	MDM2, TP53, CDKN1A, CDK2
27	eNOS Signaling36	8.6	KIT, CCNA1, CCNA2, FGFR3, FGF4, BMP2
28	Prostate cancer20	8.5	TP53, MDM2, HRAS, CDKN1A, CDK2
29	Glioma20	8.4	TP53, HRAS, MDM2, CDKN2A, CDKN1A
30	Chronic myeloid leukemia20	8.4	HRAS, CDKN1A, CDKN2A, MDM2, TP53
31	G1-S Phase Transition36	8.4	CCND2, CDKN1A, CDKN2A, CDK2, CCNA2, TP53
32	Cyclins and Cell Cycle Regulation36	8.4	CDKN1A, CDK2, CDKN2A, CCND2, CCNA1, TP53
33	p53 Mediated Apoptosis36	8.3	TP53, KIT, APAF1, MDM2, FGFR3, FGF4
34	Transcription_P53 signaling pathway41	8.3	TP53, MDM2, CDKN2A, CDK2, CDKN1A
35	DNA damage ATM/ATR regulation of G1/S checkpoint10	8.3	CCNA1, CCND2, CDKN1A, CDK2, TP53, MDM2
36	DNA damage_ATM/ATR regulation of G1/S checkpoint41	8.3	CDK2, MDM2, CCND2, CDKN1A, CCNA2, TP53
37	Melanoma20	8.2	CDKN2A, TP53, HRAS, MDM2, FGF4, CDKN1A
38	Selected targets of p5310	8.2	TP53, CDK1, CDK2, CDKN1A, HIC1, MGMT
39	PTEN Pathway36	8.2	MDM2, HRAS, TP53, FGFR3, BMP2, FGF4
40	Bladder cancer20	7.9	FGFR3, RASSF1, CDKN1A, CDKN2A, TP53, HRAS
41	Mitochondrial Apoptosis36	7.8	APAF1, FGF4, MDM2, FGFR3, CDKN2A, BMP2
42	Cellular Apoptosis Pathway36	7.8	CDKN2A, BMP2, MDM2, APAF1, TP53, FGFR3
43	Glioblastoma Multiforme36	7.7	TP53, HRAS, MDM2, MGMT, CDK2, CDKN1A
44	Pathways in cancer20	7.7	CDK2, FGFR3, MDM2, TP53, CDKN1A, RASSF1
45	p53 signaling pathway20	7.7	MDM2, CDKN1A, CDK2, CDKN2A, CDK1, CCND2
46	Akt Signaling36	7.6	MDM2, CCND2, HRAS, TP53, BMP2, FGFR3
47	Cell cycle20	7.5	CDKN2A, TP53, MDM2, CCNA1, CCNA2, CDK1
48	Molecular Mechanisms of Cancer36	6.9	CCND2, APAF1, STK11, MDM2, TP53, FGF4
49	Cell Cycle / Checkpoint Control3	6.8	CDK1, MGMT, CCNA2, MDM2, CCND2, CDKN2A
50	Pancreatic Adenocarcinoma36	6.6	MDM2, TP53, CCNA2, CCNA1, CCND2, KIT

Compounds related to male germ cell tumor according to GeneDecks:

(show top 50)    (show all 168)

id	Compound	Score	Top Affiliating Genes
1	roscovitine32	10.4	CDK1, CCNA2
2	h2o232	10.1	CGB5, APAF1
3	threonine32	10.0	FGFR3, STK10, BMP2
4	vincristine32 34 9 9	12.3	KIT, CGB5, MGMT
5	butyrolactone i32	9.3	CCND2, CCNA2, CDK1, CDK2, CDKN1A
6	7-hydroxystaurosporine32 9 9	10.8	TP53, CDK1, CDKN1A, CDK2
7	aphidicolin32	8.8	TP53, CDK2, CCNA2, CDKN1A, CDK1
8	hpvs32	8.6	CDKN1A, TP53, CDKN2A, CCNA2
9	estrogen32	8.5	HRAS, CCNA2, FGF4, BMP2, RASSF1, MGMT
10	5-methylcytosine32 18	9.5	STK11, TP53, RASSF1, CDKN2A, MGMT
11	olomoucine32 42 9 9	11.4	TP53, CCNA2, CDK2, CDKN1A, CDK1, CDKN2A
12	acnu32	8.4	MGMT, CDKN2A, CDKN1A, TP53
13	lovastatin32 42 9 9	11.3	HRAS, BMP2, CDKN2A, CCNA2, CDK2, CDKN1A
14	geldanamycin32 9 9	10.3	CDK2, CDK1, MDM2, APAF1, TP53, CDKN1A
15	crcs32	8.2	HRAS, RASSF1, CDKN2A, MGMT, APAF1, TP53
16	7,12-dimethylbenz(a)anthracene32	8.2	MGMT, CGB5, CDKN2A, MDM2
17	fludarabine32 9 9	10.2	TP53, CCND2, APAF1, MDM2, CDK2
18	temozolomide32 9 9	10.2	CDKN1A, CDK1, TP53, CDKN2A, MGMT
19	adpribose32	8.1	CCNA2, TP53, CDK1, CDK2, CDKN1A, MDM2
20	oxaliplatin32 34 9 9	11.0	CCNA2, TP53, MGMT, CDK1, CDK2, CDKN1A
21	lactacystin32	8.0	CDK2, TP53, CCNA2, APAF1, MDM2, CDK1
22	pd 98,05932	7.9	BMP2, CDKN1A, CDK2, CDK1, MDM2, CCNA2
23	rapamycin32 42	8.9	CDK1, BMP2, CDK2, MDM2, CCNA2, CCND2
24	cytarabine32 34 9 9	10.9	CCNA2, APAF1, CDK1, CDKN2A, CDK2, CDKN1A
25	docetaxel32 34 9 9	10.8	CDK1, CDKN2A, MDM2, TP53, CDKN1A, KIT
26	hydroxyurea32 9 9	9.8	KIT, TP53, CCNA2, CDK1, CDKN2A, CDK2
27	methylmethanesulfonate32	7.7	TP53, CDKN1A, CDK2, CDK1, MGMT, MDM2
28	resveratrol32 9 18 9	10.7	MDM2, APAF1, CDK2, CCND2, TP53, CDK1
29	arsenite32 18	8.6	CDKN1A, CCNA2, TP53, CDKN2A, CDK1, MDM2
30	flavopiridol32 9 9	9.5	CCNA2, TP53, CDK1, CDKN2A, MDM2, KIT
31	guanine32 9 18 9	10.2	STK11, CDK2, CDK1, MGMT, FGFR3, MDM2
32	irinotecan32 34 9 9	10.1	CCNA2, MDM2, MGMT, CDK1, TP53, CDKN2A
33	thymidylate32	7.0	CDKN1A, CDK1, MGMT, MDM2, TP53, CDK2
34	etoposide32 42 9 9	10.0	CDK2, CDKN1A, CGB5, CDK1, MGMT, MDM2
35	5-aza-2deoxycytidine32	6.9	STK11, HIC1, CCND2, MDM2, TP53, MGMT
36	oxygen32 18	7.8	CCNA2, MDM2, STK11, FGF4, CDKN1A, CGB5
37	camptothecin32 42 9 9	9.8	CDKN2A, TP53, CDK1, CCNA2, APAF1, MGMT
38	cycloheximide32	6.7	CDKN2A, KIT, BMP2, CGB5, CDK2, CDK1
39	5fluorouracil32	6.6	CCNA2, KIT, CDKN1A, MDM2, CDKN2A, CDK1
40	genistein32 9 18 9	9.4	CDKN2A, HRAS, CCNA2, APAF1, MDM2, MGMT
41	thymidine32 18	7.4	MGMT, KIT, BMP2, CCNA2, CCND2, HRAS
42	oligonucleotide32	5.9	CCNA2, TP53, CCND2, MDM2, FGFR3, MGMT
43	paraffin32	5.8	MGMT, CGB5, FGFR3, STK11, CDKN1A, CDKN2A
44	paclitaxel32 34 9 9	8.8	KIT, CGB5, CDKN1A, CCNA2, TP53, HRAS
45	cisplatin32 34 9 9	8.6	CDKN2A, MGMT, APAF1, HIC1, CCNA2, CCND2
46	progesterone32 42 9 18 9	9.6	TP53, HRAS, CDKN2A, KIT, BMP2, CGB5
47	retinoic acid32 42 18	7.4	MGMT, CCND2, APAF1, BMP2, RASSF1, CGB5
48	serine32	5.4	CDKN1A, CDKN2A, STK11, STK10, TP53, HRAS
49	doxorubicin32 34 9 9	8.3	MGMT, CCNA2, CDK1, MDM2, KIT, HRAS
50	vegf32	4.6	KIT, HRAS, CCNA1, CCNA2, APAF1, MDM2

Cellular components related to male germ cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cyclin-dependent protein kinase holoenzyme complex	GO:000307	9.5	CDK2, CCND2, CDKN1A
2	nuclear body	GO:016604	8.5	TP53, MDM2, CDKN2A
3	protein complex	GO:043234	8.3	BMP2, CDKN2A, MDM2, TP53, STK11
4	nucleoplasm	GO:005654	6.3	CDKN1A, CDK2, CDKN2A, CDK1, MDM2, CCNA2
5	cytoplasm	GO:005737	5.4	MDM2, APAF1, CCNA2, HRAS, TP53, DMAP1
6	nucleus	GO:005634	INF	CCND2, HRAS, TP53, DMAP1, , SPANXA2

Biological processes related to male germ cell tumor according to GeneDecks:

(show all 23)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitotic cell cycle G2/M transition DNA damage checkpoint	GO:007095	9.9	CCNA2, CDK1
2	spermatid development	GO:007286	9.9	KIT, ZFP42, SPANXB2, STK11
3	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.5	FGFR3, BMP2, HRAS, FGF4
4	cellular senescence	GO:090398	9.5	HRAS, CDKN1A, CDKN2A
5	insulin receptor signaling pathway	GO:008286	9.4	CDK1, FGF4, FGFR3, STK11, HRAS
6	replicative senescence	GO:090399	9.3	TP53, CDKN1A, CDKN2A
7	protein destabilization	GO:031648	9.3	BMP2, CDKN2A, MDM2
8	induction of apoptosis by intracellular signals	GO:008629	9.3	CDKN1A, TP53, APAF1, HRAS
9	G2/M transition of mitotic cell cycle	GO:000086	9.2	CDK1, CCNA1, CDKN1A, CDK2, CCNA2
10	traversing start control point of mitotic cell cycle	GO:007089	9.1	CDK2, MDM2
11	response to DNA damage stimulus	GO:006974	9.1	CDKN1A, STK11, TP53, RASSF1
12	fibroblast growth factor receptor signaling pathway	GO:008543	9.0	MDM2, HRAS, CDK1, FGFR3, FGF4
13	cellular response to ionizing radiation	GO:071479	8.9	MGMT, TP53, CDKN1A
14	G1/S transition of mitotic cell cycle	GO:000082	8.9	CCNA1, CDK1, CDKN2A, CDKN1A, CDK2
15	negative regulation of cell growth	GO:030308	8.8	STK11, TP53, CDKN2A, CDKN1A
16	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO:006977	8.7	MDM2, CDKN1A, TP53, CDK2
17	mitotic cell cycle	GO:000278	8.6	CDKN2A, CCNA2, CDK1, CCNA1, CDK2, CDKN1A
18	cell cycle arrest	GO:007050	8.6	STK11, TP53, CDKN2A, HRAS, CDKN1A, RASSF1
19	positive regulation of cell proliferation	GO:008284	8.3	FGFR3, CDK2, FGF4, HRAS, MDM2, KIT
20	negative regulation of cell proliferation	GO:008285	8.3	CDKN2A, STK11, TP53, HRAS, CDKN1A, BMP2
21	cell cycle checkpoint	GO:000075	8.0	TP53, MDM2, CDK1, CDKN2A, CDK2, CDKN1A
22	Ras protein signal transduction	GO:007265	7.9	CDKN2A, CDK2, CDK1, CCNA2, RASSF1, TP53
23	negative regulation of transcription from RNA polymerase II promoter	GO:000122	INF	, HIC1, TP53, DMAP1, BMP2, MDM2

Molecular functions related to male germ cell tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	histone kinase activity	GO:035173	9.7	CDK2, CDK1
2	cyclin binding	GO:030332	9.4	CDKN1A, CDK1, CDK2
3	p53 binding	GO:002039	9.1	STK11, MDM2, CDKN2A
4	protein kinase binding	GO:019901	8.5	CCNA2, CCND2, CCNA1, TP53, CDKN2A
5	protein binding	GO:005515	4.6	CCNA2, CCNA1, TP53, DMAP1, HIC1, STK10