MCID: MLG083
MIFTS: 44

Male Germ Cell Tumor malady

Cancer diseases category

Summaries for Male Germ Cell Tumor

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34MalaCards
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MalaCards: Male Germ Cell Tumor is related to seminoma and germ cell tumors. An important gene associated with Male Germ Cell Tumor is MGCT (male germ cell tumor), and among its related pathways are AMPK signaling and Senescence and Autophagy. The compounds crcs and fludarabine have been mentioned in the context of this disorder. Related mouse phenotypes are hearing/vestibular/ear and digestive/alimentary.

Aliases & Classifications for Male Germ Cell Tumor

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48OMIM, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

male germ cell tumor 48 63


Related Diseases for Male Germ Cell Tumor

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18GeneCards, 19GeneDecks
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Diseases related to Male Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.1CCNA2, CCND2, RASSF1, KIT, CDK2, CGB5
2germ cell tumors10.9
3male germ cell tumor, somatic10.4
4giant cell glioblastoma10.1MDM2
5anaplastic ependymoma10.1MDM2
6spitz nevus10.1HRAS
7acute myeloid leukemia10.1CCNA1
8actinic keratosis10.1TP53
9pleomorphic liposarcoma10.1MDM2, KIT
10choroid plexus papilloma10.1TP53
11dedifferentiated liposarcoma10.1KIT, MDM2
12teratocarcinoma10.1FGF4, BMP2, ZFP42
13uterine sarcoma10.1KIT, MDM2
14phyllode tumor10.1CCNA2, KIT
15liposarcoma10.1MDM2, TP53
16malignant fibroxanthoma10.1CCNA2, BMP2, MDM2
17brain cancer10.1MGMT, MDM2
18pleomorphic adenoma10.1BMP2, MDM2, HRAS
19follicular thyroid carcinoma10.1CDKN1A, RASSF1
20malignant peripheral nerve sheath tumor10.1BMP2, KIT, MDM2
21anaplastic oligodendroglioma10.1MDM2, MGMT
22benign meningioma10.1CCNA2, MDM2
23synovial sarcoma10.0RASSF1, KIT, MDM2
24nasopharynx carcinoma10.0TP53, RASSF1
25germinoma10.0KIT, CGB5
26wilms tumor10.0CCND2, CCNA1, RASSF1
27esophageal cancer10.0FGF4, MDM2, TP53
28ependymoma10.0MDM2, RASSF1, MGMT
29stomach cancer10.0TP53
30colon adenocarcinoma10.0HRAS, CDKN1A, CCNA2
31li-fraumeni syndrome10.0TP53, MDM2, CDKN1A
32breast cancer, invasive ductal10.0CDKN1A, MDM2, TP53
33dysgerminoma10.0CGB5, KIT
34hematologic cancer10.0HRAS, KIT, CCNA2
35burkitt's lymphoma10.0CCNA2, CCND2, RASSF1, MDM2
36liver cirrhosis10.0HRAS, RASSF1, CCNA2, HIC1
37bladder carcinoma in situ10.0TP53, RASSF1, HRAS
38multiple myeloma10.0HRAS, CCND2, TP53
39gallbladder cancer10.0TP53, HRAS
40rhabdomyosarcoma10.0MDM2, CCND2, TP53
41malignant mixed mullerian tumor10.0TP53, KIT
42acute leukemia10.0APAF1, CCNA2, KIT, HRAS
43bladder transitional cell carcinoma10.0TP53, CGB5
44fibrosarcoma10.0APAF1, MDM2, CDKN1A
45acute lymphoblastic leukemia, childhood10.0CDK2, MDM2, CCNA2
46non-hodgkin lymphoma10.0CDK1, MDM2, CCND2, APAF1
47familial adenomatous polyposis10.0RASSF1, TP53, MGMT
48kidney cancer10.0APAF1, RASSF1, KIT, HRAS
49testicular cancer10.0CGB5, CCNA1, CCNA2, MGMT
50cervical adenocarcinoma10.0CDKN1A, RASSF1

Graphical network of the top 20 diseases related to Male Germ Cell Tumor:



Diseases related to male germ cell tumor

Symptoms for Male Germ Cell Tumor

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Drugs & Therapeutics for Male Germ Cell Tumor

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Male Germ Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Male Germ Cell Tumor

Search NIH Clinical Center for Male Germ Cell Tumor

Search CenterWatch for Male Germ Cell Tumor

Genetic Tests for Male Germ Cell Tumor

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Anatomical Context for Male Germ Cell Tumor

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Animal Models for Male Germ Cell Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Male Germ Cell Tumor:

38 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.3HIC1, APAF1, BMP2, KIT, CDKN1A
2MP:00053818.9HIC1, APAF1, TP53, BMP2, KIT, MDM2
3MP:00053828.8HIC1, APAF1, TP53, BMP2, KIT, MDM2
4MP:00053888.7APAF1, TP53, KIT, CDKN1A, HRAS, FGF4
5MP:00030128.7MGMT, DMAP1, TP53, KIT, MDM2, CDKN1A
6MP:00053718.6HIC1, APAF1, TP53, BMP2, KIT, MDM2
7MP:00107718.5HIC1, TP53, KIT, MDM2, CDKN1A, CDK2
8MP:00053908.3HIC1, APAF1, TP53, BMP2, KIT, MDM2
9MP:00053788.2TP53, BMP2, KIT, MDM2, CDKN1A, CDK2
10MP:00036318.1HIC1, APAF1, TP53, CCND2, BMP2, KIT
11MP:00053918.1APAF1, TP53, CCND2, KIT, CDKN1A, CDK2
12MP:00053707.8TP53, CCND2, KIT, MDM2, CDK1, CDKN1A
13MP:00053857.8BMP2, CCND2, TP53, APAF1, RASSF1, KIT
14MP:00053977.8TP53, CCNA2, CCND2, CCNA1, KIT, MDM2
15MP:00028737.6BMP2, TP53, APAF1, HIC1, RASSF1, KIT
16MP:00053807.5HIC1, APAF1, TP53, CCNA2, BMP2, KIT
17MP:00053877.3HIC1, APAF1, TP53, CCNA2, CCND2, CCNA1
18MP:00020067.2MGMT, HIC1, APAF1, TP53, RASSF1, KIT
19MP:00053767.0MGMT, TP53, CCND2, BMP2, RASSF1, KIT
20MP:00053796.7MGMT, APAF1, TP53, ZFP42, CCND2, CCNA1
21MP:00053846.4CCNA2, ZFP42, TP53, APAF1, DMAP1, CCNA1
22MP:00053896.3CCND2, ZFP42, TP53, APAF1, DMAP1, CCNA1
23MP:00107684.7FGF4, MGMT, DMAP1, HIC1, APAF1, TP53

Publications for Male Germ Cell Tumor

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53PubMed
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Articles related to Male Germ Cell Tumor:

(show all 24)
idTitleAuthorsYear
1
Endocrine disruptors, gene deregulation and male germ cell tumors. (23784834)
2013
2
Modified cisplatin, etoposide, and ifosfamide (PEI) salvage therapy for male germ cell tumors: long-term efficacy and safety outcomes. (23860612)
2013
3
Suboptimal survival of male germ-cell tumors in southern Portugal--a population-based retrospective study for cases diagnosed in 1999 and 2000. (21030383)
2011
4
Case-control study of male germ cell tumors nested in a cohort of car-manufacturing workers: Findings from the occupational history. (20860055)
2010
5
Serum tumor markers in the evaluation of male germ cell tumors. (21068762)
2010
6
Analysis of 7 immunohistochemical markers in male germ cell tumors demonstrates the prognostic significance of p53 and MIB-1. (19331230)
2009
7
Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors. (18622385)
2008
8
Determination of hyperglycosylated human chorionic gonadotropin produced by malignant gestational trophoblastic neoplasias and male germ cell tumors using a lectin-based immunoassay and surface plasmon resonance. (17081681)
2007
9
Kit expression in male germ cell tumors. (17595797)
2007
10
Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors. (16424014)
2006
11
Feasibility and usefulness of high-dose chemotherapy (high-dose ifosfamide, carboplatin and etoposide) combined with peripheral blood stem cell transplantation for male germ cell tumor: a single-institute experience. (17001179)
2006
12
High-dose chemotherapy for male germ cell tumor. (16903926)
2006
13
Analysis of p16INK4A gene promoter in male germ-cell tumors: identification of a new point mutation. (15734211)
2005
14
High dose chemotherapy including paclitaxel (T-ICE) combined with peripheral blood stem cell transplantation for male germ cell tumor. Preliminary report. (16409617)
2005
15
Elevated levels and distinct patterns of expression of A-type cyclins and their associated cyclin-dependent kinases in male germ cell tumors. (14696091)
2004
16
Role of promoter hypermethylation in Cisplatin treatment response of male germ cell tumors. (15149548)
2004
17
ID gene expression varies with lineage during differentiation of pluripotential male germ cell tumor cell lines. (11320653)
2001
18
A male germ cell tumor-susceptibility-determining locus, pgct1, identified on murine chromosome 13. (10890890)
2000
19
Genetic analysis of the APAF1 gene in male germ cell tumors. (10862031)
2000
20
The cytogenetic theory of the pathogenesis of human adult male germ cell tumors. Review article. (9524565)
1998
21
A genetic perspective of male germ cell tumors. (9562446)
1998
22
Human male germ cell tumor resistance to cisplatin is linked to TP53 gene mutation. (9620551)
1998
23
Physical mapping of a commonly deleted region, the site of a candidate tumor suppressor gene, at 12q22 in human male germ cell tumors. (8812492)
1996
24
Allelic loss and somatic differentiation in human male germ cell tumors. (7518576)
1994

Variations for Male Germ Cell Tumor

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Expression for genes affiliated with Male Germ Cell Tumor

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Male Germ Cell Tumor

Search GEO for disease gene expression data for Male Germ Cell Tumor.

Pathways for genes affiliated with Male Germ Cell Tumor

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 54QIAGEN, 55R&D Systems, 58SinoBiological, 13EMD Millipore, 31KEGG, 56Reactome, 5Cell Signaling Technology
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Pathways related to Male Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CDKN1A, CCNA1, CCNA2, TP53
29.3MDM2, TP53, BMP2, CDKN1A, HRAS
39.3MDM2, CDKN1A, CCNA2, CDK2
49.2TP53, MDM2, CDKN1A, CDK2
5
Show member pathways
ATM Signaling Pathway39
9.2TP53, MDM2, CDK2, CDKN1A
69.2TP53, CDKN1A, CDK2, MDM2
79.2CDKN1A, MDM2, TP53, APAF1, HIC1
8
Show member pathways
p53 pathway39
9.0CCNA2, RASSF1, MDM2, CDK2, TP53
9
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.0CDKN1A, TP53, HRAS, CCND2, MDM2
10
Show member pathways
Signal transduction PTEN pathway61
8.8HRAS, CDKN1A, MDM2, TP53, KIT, CCNA1
118.8CCND2, MDM2, TP53, CDKN1A, CCNA1
12
Show member pathways
8.8CDK2, TP53, CDKN1A, MDM2, CCNA1
138.8CDK2, CDKN1A, CCNA2, TP53, APAF1, MDM2
14
Show member pathways
PLK2 and PLK4 events39
Polo-like kinase signaling events in the cell cycle39
8.7CCND2, MDM2, CDKN1A, CDK2, HRAS
15
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
8.7HRAS, CDK2, CDKN1A, CCND2, CCNA2
168.7CDKN1A, HRAS, MDM2, RASSF1, CCND2, TP53
178.7MDM2, TP53, CDKN1A, CDK2, HRAS, MGMT
18
Show member pathways
8.7FGF4, MDM2, KIT, BMP2, TP53, APAF1
19
Show member pathways
8.6MDM2, CDK2, TP53, CCNA2, CDKN1A, CCNA1
20
Show member pathways
8.5CCNA2, CCNA1, CDK2, CDK1
21
Show member pathways
8.5CCNA1, CDK1, CCNA2, CDK2
228.5CCNA1, CCNA2, CDK2, CDK1
23
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
8.4MDM2, TP53, CDK2, HRAS, CDK1
24
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.4CCNA2, CCNA1, TP53, APAF1, CDKN1A, HRAS
258.3RASSF1, CDK2, CDK1, CCNA1, CCNA2
26
Show member pathways
8.3CCND2, CCNA1, CDK2, CCNA2, TP53, CDKN1A
278.3CCNA2, CCND2, CCNA1, CDKN1A, TP53, CDK2
28
Show member pathways
8.3KIT, MDM2, FGF4, CDK1, HRAS, CDKN1A
29
Show member pathways
8.3HRAS, FGF4, CDKN1A, MDM2, KIT, CDK1
30
Show member pathways
8.2CDK2, CCND2, CCNA2, APAF1, HRAS, BMP2
318.1CDK1, MDM2, CCNA2, TP53, CDK2, CDKN1A
328.1CDKN1A, CDK2, CDK1, APAF1, CCNA2, HIC1
33
Show member pathways
8.1MDM2, KIT, TP53, CDKN1A, FGF4, CCND2
348.1TP53, CDK2, CDKN1A, MDM2, CCNA1, CCND2
358.0TP53, MGMT, HIC1, CDK1, CDKN1A, CDK2
36
Show member pathways
Signaling Pathways in Glioblastoma39
7.8TP53, CCND2, RASSF1, MDM2, CDKN1A, CDK2
377.8CDK1, CDK2, CDKN1A, MDM2, CCNA1, CCNA2
38
Show member pathways
Cell cycle ESR1 regulation of G1 S transition61
Immune response MIF JAB1 signaling61
Cell cycle Cell cycle generic schema 61
7.8CCNA1, CDK2, CCNA2, CDK1, CDKN1A, CCND2
39
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation61
7.8CCND2, CDK2, CCNA1, CDK1, CDKN1A, CCNA2
407.8TP53, KIT, MDM2, CCND2, FGF4, HRAS
41
Show member pathways
DNA damage response39
7.6CDK1, MDM2, CCND2, TP53, APAF1, CDK2
42
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
7.6TP53, CDK1, APAF1, CDK2, CCNA2, CDKN1A
437.5HRAS, RASSF1, TP53, CCNA1, BMP2, KIT
44
Show member pathways
7.4KIT, APAF1, TP53, BMP2, CDKN1A, CDK2
45
Show member pathways
7.3MGMT, CCNA2, CCND2, CDKN1A, MDM2, CDK1
46
Show member pathways
7.2CDK2, TP53, CCND2, CCNA1, MDM2, CDK1
47
Show member pathways
7.2CDK2, CDKN1A, CCNA1, MDM2, CDK1, CCNA2
48
Show member pathways
Cell cycle39
7.2CCNA1, CCND2, CDK1, CCNA2, TP53, CDK2
497.0MDM2, CCNA2, CCNA1, CDK1, CDKN1A, CDK2
50
Show member pathways
7.0MDM2, BMP2, CCNA1, CCND2, CCNA2, TP53

Compounds for genes affiliated with Male Germ Cell Tumor

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 3BitterDB
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Compounds related to Male Germ Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 183)
idCompoundScoreTop Affiliating Genes
1crcs469.5RASSF1, TP53, APAF1, MGMT, HRAS
2fludarabine46 52 1210.9MDM2, CDK2, TP53, APAF1, CCND2
3vincristine46 52 1210.9MGMT, TP53, MDM2, CGB5, KIT, CCNA2
47-hydroxystaurosporine46 129.8CDKN1A, TP53, CDK1, CDK2
5olomoucine46 129.7CDKN1A, CDK1, CCNA2, TP53, CDK2
6aphidicolin468.7TP53, CDKN1A, CCNA2, CDK1, CDK2
7docetaxel46 52 62 1211.6CDK1, TP53, KIT, MDM2, CCNA2, CDKN1A
85-aza-2deoxycytidine468.6MDM2, CDKN1A, RASSF1, TP53, CCND2, MGMT
9butyrolactone i468.6CCND2, CDK2, CDKN1A, CCNA2, CDK1
10irinotecan46 52 1210.5CDK1, MDM2, CDKN1A, KIT, CCNA2, TP53
11roscovitine468.5CDK2, TP53, CCNA2, CDKN1A, MDM2, CDK1
12methylmethanesulfonate468.4CDKN1A, TP53, MDM2, CDK1, CDK2, MGMT
13oxaliplatin46 52 1210.4CDK2, CDKN1A, MGMT, TP53, CCNA2, CDK1
14mimosine46 129.4CDK2, CCNA2, CDK1, CDKN1A
15adpribose468.3MDM2, CDK1, APAF1, TP53, CDK2, CDKN1A
16lactacystin468.3CDK1, MDM2, APAF1, CDKN1A, CCNA2, TP53
17vinblastine46 52 1210.3MDM2, CCNA2, CGB5, TP53, CDK1
18flavopiridol46 129.3CDKN1A, CDK1, TP53, MDM2, KIT, CCNA2
19geldanamycin46 52 62 1211.3CDKN1A, CDK1, MDM2, KIT, APAF1, TP53
20cytarabine46 52 1210.2CCNA2, KIT, CDK1, CDKN1A, CDK2, TP53
21thymidylate468.2TP53, MGMT, MDM2, CDK2, CDKN1A, CDK1
22curcumin468.1TP53, MDM2, CDK1, CDK2, CDKN1A, MGMT
23arsenite46 259.1MDM2, CDK2, CDKN1A, CDK1, CCNA2, TP53
24oligonucleotide468.1TP53, HRAS, MGMT, CDKN1A, CCNA2, MDM2
25camptothecin46 62 1210.1CDKN1A, MDM2, CCNA2, TP53, APAF1, MGMT
26ly294002468.0MDM2, CDK1, CCNA2, HRAS, TP53, CDK2
27actinomycin d468.0CDK2, CGB5, TP53, CDKN1A, MDM2, KIT
28nitric oxide46 25 1210.0CGB5, MDM2, KIT, BMP2, HRAS, CCNA2
295fluorouracil468.0TP53, MGMT, MDM2, CDK1, CDKN1A, CDK2
30hydroxyurea46 52 129.9CDK2, KIT, TP53, CDK1, CGB5, CCNA2
31threonine467.8CDK2, HRAS, KIT, CDKN1A, CDK1, CCNA2
32resveratrol46 62 25 1210.7CDK2, CDKN1A, CDK1, MDM2, BMP2, CCND2
33paraffin467.6CCNA2, MDM2, HRAS, TP53, MGMT, CDKN1A
34rapamycin467.6CDKN1A, HRAS, CDK2, CDK1, CCNA2, CCND2
35pd 98,059467.6MDM2, CCNA2, CCND2, BMP2, KIT, CDK1
36etoposide46 52 62 1210.5CGB5, CCNA2, CDK2, CDKN1A, CDK1, MDM2
37h2o2467.4MDM2, CCNA2, TP53, APAF1, CDK1, CDKN1A
38cycloheximide467.4CGB5, CDK2, CDK1, TP53, CCNA2, BMP2
39genistein46 30 62 3 25 1212.3CGB5, MDM2, HRAS, CDK2, CDKN1A, CDK1
40oxygen46 258.1CDK2, CDK1, CDKN1A, HRAS, FGF4, APAF1
41thymidine46 258.1HRAS, CDK2, CDKN1A, CDK1, MDM2, KIT
42paclitaxel46 52 129.0CGB5, HRAS, CDK2, CDKN1A, CDK1, MDM2
43serine466.9KIT, CDKN1A, CDK2, HRAS, CGB5, MDM2
44progesterone46 30 62 25 1210.5KIT, BMP2, CCND2, CCNA2, TP53, MGMT
45doxorubicin46 52 128.5CGB5, HRAS, CDK2, CDKN1A, CDK1, MDM2
46tyrosine466.4BMP2, MDM2, FGF4, CGB5, CCND2, CCNA2
47cisplatin46 52 62 129.2MDM2, RASSF1, CCND2, TP53, APAF1, HIC1
48vegf466.0CCNA2, CCNA1, BMP2, KIT, TP53, APAF1
49estrogen465.8MDM2, KIT, CDK1, CDKN1A, CDK2, HRAS
50retinoic acid46 256.4CDK1, KIT, RASSF1, BMP2, CCNA1, CCND2

GO Terms for genes affiliated with Male Germ Cell Tumor

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Sources:
17Gene Ontology
See all sources

Cellular components related to Male Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replication forkGO:0056579.7TP53, DMAP1
2cyclin-dependent protein kinase holoenzyme complexGO:0003079.2CCND2, CDKN1A, CDK2
3chromatinGO:0007859.2HIC1, TP53, CCND2
4nucleoplasmGO:0056547.1MGMT, DMAP1, TP53, CCNA2, CCNA1, MDM2
5cytosolGO:0058296.6APAF1, TP53, CCND2, CCNA1, MDM2, CDK1
6cytoplasmGO:0057376.5DMAP1, HIC1, TP53, ZFP42, CCNA2, RASSF1
7nucleusGO:0056345.3FGF4, MGMT, DMAP1, HIC1, APAF1, TP53

Biological processes related to Male Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 43)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell cycle arrestGO:07115710.2MDM2, RASSF1
2mitotic cell cycle arrestGO:07185010.2TP53, CDKN1A
3regulation of G2/M transition of mitotic cell cycleGO:01038910.2CCNA1, CCNA2
4protein destabilizationGO:03164810.2MDM2, BMP2
5positive regulation of MAPK cascadeGO:04341010.1HRAS, KIT, BMP2
6cellular senescenceGO:09039810.1HRAS, CDKN1A
7cellular response to ionizing radiationGO:07147910.0MGMT, TP53, CDKN1A
8regulation of cyclin-dependent protein serine/threonine kinase activityGO:00007910.0CCNA2, CCNA1, CDKN1A
9positive regulation of cell migrationGO:03033510.0BMP2, KIT, HRAS
10mitotic G1 DNA damage checkpointGO:0315719.9TP53, CDK2
11intrinsic apoptotic signaling pathwayGO:0971939.9HRAS, CDKN1A, TP53, APAF1
12positive regulation of ERK1 and ERK2 cascadeGO:0703749.9FGF4, HRAS, BMP2
13DNA methylationGO:0063069.9DMAP1, MGMT
14cell cycle arrestGO:0070509.8HRAS, CDKN1A, RASSF1, TP53
15phosphatidylinositol-mediated signalingGO:0480159.7KIT, MDM2, CDKN1A, FGF4
16mitotic G2 DNA damage checkpointGO:0070959.7CCNA2, CDK1
17negative regulation of cell proliferationGO:0082859.7HRAS, CDKN1A, BMP2, TP53
18cellular response to DNA damage stimulusGO:0069749.7CDKN1A, RASSF1, TP53
19DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGO:0069779.6TP53, MDM2, CDKN1A, CDK2
20organ regenerationGO:0311009.6CDKN1A, CDK1, CCNA2
21positive regulation of protein phosphorylationGO:0019349.5FGF4, HRAS, BMP2, CCND2
22activation of MAPK activityGO:0001879.5BMP2, KIT, CDK1
23response to toxic substanceGO:0096369.5MGMT, CDK1, CDKN1A
24protein complex assemblyGO:0064619.4TP53, MDM2, CDK1
25positive regulation of gene expressionGO:0106289.4CDK1, MDM2, KIT, BMP2
26negative regulation of transcription from RNA polymerase II promoterGO:0001229.3MDM2, BMP2, TP53, HIC1, DMAP1
27response to drugGO:0424939.2MGMT, MDM2, CDK1, CDKN1A
28negative regulation of transcription, DNA-templatedGO:0458929.2MDM2, BMP2, TP53, DMAP1
29positive regulation of cell proliferationGO:0082849.2KIT, MDM2, CDK2, HRAS, FGF4
30insulin receptor signaling pathwayGO:0082869.0CDK1, HRAS, FGF4
31regulation of transcription involved in G1/S transition of mitotic cell cycleGO:0000839.0CCNA1, CDK1
32G1/S transition of mitotic cell cycleGO:0000828.9CCNA1, CDK1, CDKN1A, CDK2
33mitosisGO:0070678.9CDK2, CDK1, CCNA1, CCNA2
34negative regulation of apoptotic processGO:0430668.8TP53, MDM2, CDK1, CDKN1A, FGF4
35DNA repairGO:0062818.7MGMT, DMAP1, CDK1, CDK2
36fibroblast growth factor receptor signaling pathwayGO:0085438.7KIT, MDM2, CDK1, CDKN1A, HRAS, FGF4
37Fc-epsilon receptor signaling pathwayGO:0380958.7KIT, MDM2, CDK1, CDKN1A, HRAS, FGF4
38epidermal growth factor receptor signaling pathwayGO:0071738.7KIT, MDM2, CDK1, CDKN1A, HRAS, FGF4
39neurotrophin TRK receptor signaling pathwayGO:0480118.7KIT, MDM2, CDK1, CDKN1A, HRAS, FGF4
40G2/M transition of mitotic cell cycleGO:0000868.7CCNA2, CCNA1, CDK1, CDKN1A, CDK2
41innate immune responseGO:0450878.7KIT, MDM2, CDK1, CDKN1A, HRAS, FGF4
42mitotic cell cycleGO:0002788.7CDK2, CDKN1A, CDK1, CCNA1, CCNA2
43Ras protein signal transductionGO:0072658.3HRAS, TP53, CCNA2, RASSF1, CDK1, CDKN1A

Molecular functions related to Male Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase bindingGO:0199019.1CCNA1, CCND2, CCNA2, TP53
2histone kinase activityGO:0351738.8CDK2, CDK1
3cyclin bindingGO:0303328.8CDK1, CDKN1A, CDK2
4protein bindingGO:0055155.3HRAS, DMAP1, HIC1, APAF1, TP53, CCNA2

Products for genes affiliated with Male Germ Cell Tumor

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Sources for Male Germ Cell Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet