MCID: MLN007
MIFTS: 56

Male Infertility malady

Genetic category

Summaries for Male Infertility

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. causes of male infertility include physical problems with the testicles blockages in the ducts that carry sperm hormone problems a history of high fevers or mumps genetic disorders lifestyle or environmental factors about a third of the time, infertility is because of a problem with the man. one third of the time, it is a problem with the woman. sometimes no cause can be found. if you suspect you are infertile, see your doctor. there are tests that may tell if you have fertility problems. when it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technologies. happily, two-thirds of couples treated for infertility are able to have babies. nih: national institute of child health and human development

MalaCards: Male Infertility, also known as infertility, male, is related to infertility and azoospermia. An important gene associated with Male Infertility is UBE2B (ubiquitin-conjugating enzyme E2B), and among its related pathways are Viral carcinogenesis and Fertilization. The drugs clomiphene and clomiphene citrate and the compounds pgf and nnc55-0396 have been mentioned in the context of this disorder. Related mouse phenotype reproductive system.

Wikipedia:64 Male infertility refers to the inability of a male to achieve a pregnancy in a fertile female. In humans... more...

Aliases & Classifications for Male Infertility

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 34MedlinePlus, 61UMLS, 22GTR, 45Novoseek, 35MeSH, 57SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic


Aliases & Descriptions:

male infertility 8 47 10 34 61
infertility, male 8 22
male infertility, unspecified 8
male infertility nos 8
infertility male 45


External Ids:

Disease Ontology8 DOID:12336
MeSH35 D007248
ICD9CM27 606.9, 606
ICD1025 Q98.6, Q98.7

Related Diseases for Male Infertility

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Male Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1infertility32.1DAZ1, EPPIN, USP26, AZF1
2azoospermia30.9AZF1, USP26, DDX3Y, FKBP6, DAZ1, H2BFWT
3oligospermia30.4DAZ1
4cryptorchidism30.4DAZ1, AZF1
5y chromosome infertility30.0DAZ1, DDX3Y
6varicocele10.6
7deafness-infertility syndrome10.5
8catsper1-related nonsyndromic male infertility10.5
9klinefelter's syndrome10.4
10trachoma10.4
11catsper-related male infertility10.4
12spermatogenic failure 410.4
13cystic fibrosis10.3
14congenital adrenal hyperplasia10.3
15orchitis10.2
16n syndrome10.2
17adrenal rest tumor10.2
18spermatocele10.2
19polycystic kidney disease10.2
20micro syndrome10.2
21catsper-related nonsyndromic male infertility10.2
22spinal cord injury10.2
23testicular microlithiasis10.2
24deafness and male infertility10.2
25male infertility due to acrosin deficiency10.2
26vesiculitis10.2
27teratocarcinoma10.0
28hyperprolactinemia10.0
29hydronephrosis10.0
30prostatic cyst10.0
31mulibrey nanism10.0
32carney complex10.0
33panhypopituitarism10.0
34urethral diverticulum10.0
35primary ciliary dyskinesia10.0
36protein s deficiency10.0
37situs inversus10.0
38morbid obesity10.0
39imperforate anus10.0
40fibrous dysplasia10.0
41alopecia10.0
42arthritis10.0
43autosomal recessive disease10.0
44testicular cancer10.0
45tuberculosis10.0
46late-onset congenital adrenal hyperplasia10.0
47kartagener syndrome10.0
48warburg micro syndrome10.0
49protein r deficiency10.0
50spermatogenic failure 510.0

Graphical network of the top 20 diseases related to Male Infertility:



Diseases related to male infertility

Clinical Features for Male Infertility

Drugs & Therapeutics for Male Infertility

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Male Infertility

Drug clinical trials:

Search ClinicalTrials for Male Infertility

Search NIH Clinical Center for Male Infertility

Search CenterWatch for Male Infertility

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Male Infertility

Sources:
22GTR
See all sources

Genetic tests related to Male Infertility:

id Genetic test Affiliating Genes
1 Male Infertility22

Anatomical Context for Male Infertility

Sources:
31LifeMap Discovery™
See all sources

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Male Infertility:
id TissueAnatomical CompartmentCell Relevance
1 TestisSeminiferous TubulesElongated Spermatid Affected by disease
2 TestisSeminiferous TubulesSpermatid Affected by disease
3 TestisSeminiferous TubulesSpermatozoan Affected by disease

Animal Models for Male Infertility or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Male Infertility:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.9OAZ3, FKBP6, TBPL1, UBE2B, AURKC, CATSPER2

Publications for Male Infertility

Sources:
51PubMed
See all sources

Articles related to Male Infertility:

(show top 50)    (show all 762)
idTitleAuthorsYear
1
The field of male infertility moves fast! (24286780)
2014
2
Current management of male infertility. (24286779)
2014
3
Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. (23512232)
2013
4
No CAG repeat expansion of polymerase gamma is associated with male infertility in Tamil Nadu, South India. (24339545)
2013
5
Phospholipase CIP rescues failed oocyte activation in a prototype of male factor infertility. (22999959)
2013
6
Disruption of Ttll5/stamp gene (tubulin tyrosine ligase-like protein 5/SRC-1 and TIF2-associated modulatory protein gene) in male mice causes sperm malformation and infertility. (23558686)
2013
7
Urinary phytoestrogen levels related to idiopathic male infertility in Chinese men. (23820060)
2013
8
NPHP4 mutation is linked to cerebello-oculo-renal syndrome and male infertility. (23574405)
2013
9
Ubiquitin-specific protease (USP26) gene alterations associated with male infertility and recurrent pregnancy loss (RPL) in Iranian infertile patients. (23779098)
2013
10
Human olfactory sensitivity for bourgeonal and male infertility: a preliminary investigation. (23525651)
2013
11
Seminal volume in the investigation of male infertility. (22414356)
2012
12
Mechanism, assessment, and incidence of male infertility after inguinal hernia surgery: a review of the preclinical and clinical literature. (22578405)
2012
13
Association study of single-nucleotide polymorphisms in FASLG, JMJDIA, LOC203413, TEX15, BRDT, OR2W3, INSR, and TAS2R38 genes with male infertility. (22016351)
2012
14
SEPT12 mutations cause male infertility with defective sperm annulus. (22275165)
2012
15
Apoptosis, spermatogenesis and male infertility. (22201910)
2012
16
The glutathione-S-transferase gene polymorphisms (GSTM1 and GSTT1) and idiopathic male infertility risk: a meta-analysis. (23026209)
2012
17
A single-nucleotide polymorphism in TP53 may be a genetic risk factor for Iranian patients with idiopathic male infertility. (21943018)
2012
18
Re: Analysis of GSTM1, GSTT1, and CYP1A1 in Idiopathic Male Infertility. (22423939)
2012
19
Empirical medical therapy for idiopathic male infertility: a survey of the American Urological Association. (22264467)
2012
20
Robotic approaches for male infertility and chronic orchialgia microsurgery. (21934622)
2011
21
Primary male infertility in Izmir/Turkey: a cytogenetic and molecular study of 187 infertile Turkish patients. (21340528)
2011
22
Quantifying the effectiveness and cost-efficiency of food supplementation with antioxidants for male infertility. (21764380)
2011
23
The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy. (21546386)
2011
24
Human sperm physiology: estrogen receptor alpha (ERI+) and estrogen receptor beta (ERI^) influence sperm metabolism and may be involved in the pathophysiology of varicocele-associated male infertility. (21344398)
2011
25
The role of intrauterine insemination in male infertility. (21117932)
2010
26
The use of transgenic mouse models in the study of male infertility. (20536325)
2010
27
Mendelian genetics of male infertility. (21382200)
2010
28
Eurycoma longifolia Jack in managing idiopathic male infertility. (20348942)
2010
29
Idiopathic male infertility is strongly associated with aberrant methylation of MEST and IGF2/H19 ICR1. (19878521)
2010
30
Association of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility. (19815951)
2009
31
Imaging of male infertility: pictorial review. (19458104)
2009
32
Male infertility and the involvement of the X chromosome. (19515807)
2009
33
Follicle-stimulating hormone treatment of male infertility. (18832946)
2008
34
Gene transfer to sperm and testis: future prospects of gene therapy for male infertility. (18393832)
2008
35
Florence-Utah symposium on the genetics of male infertility. (18644090)
2008
36
Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. (17442852)
2007
37
Partial deletions are associated with an increased risk of complete deletion in AZFc: a new insight into the role of partial AZFc deletions in male infertility. (17412880)
2007
38
The genetics of male infertility: a field of study whose time is now. (16728342)
2006
39
Involvement of ALF in human spermatogenesis and male infertility. (16525715)
2006
40
Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. (17047026)
2006
41
The clinical significance of the POLG gene polymorphism in male infertility. (15356024)
2004
42
CAG repeat length in the androgen receptor gene affects the risk of male infertility. (14511213)
2003
43
The present and future state of hormonal treatment for male infertility. (12638778)
2003
44
Genetic variations of gpx-4 and male infertility in humans. (12606444)
2003
45
Lack of association between polymorphisms in the testis-specific angiotensin converting enzyme gene and male infertility in an Asian population. (11870238)
2002
46
Expansion of the CAG trinucleotide repeats in the androgen receptor gene and male infertility: a controversial association. (11545285)
2001
47
Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. (11120760)
2000
48
Correlation between creatine kinase activity, lipid-peroxidation and water test in male infertility. (10734332)
1999
49
Y chromosome and male infertility]. (9644848)
1998
50
Human chromosome deletions in Yq11, AZF candidate genes and male infertility: history and update. (9733430)
1998

Genetic Variations for Male Infertility

Expression for genes affiliated with Male Infertility

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Male Infertility

Search GEO for disease gene expression data for Male Infertility.

Pathways for genes affiliated with Male Infertility

Sources:
30KEGG, 54Reactome
See all sources

Pathways related to Male Infertility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7H2BFWT, TBPL1, DDX3Y
2
Hide members
10.6CATSPER2, CATSPER1

Compounds for genes affiliated with Male Infertility

Sources:
29IUPHAR, 45Novoseek, 11DrugBank
See all sources

Compounds related to Male Infertility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pgf2910.7CATSPER2, CATSPER1
2nnc55-03962910.6CATSPER2, CATSPER1
3mibefradil45 29 1112.6CATSPER2, CATSPER1
4pge12910.5CATSPER1, CATSPER2
5pge22910.3CATSPER2, CATSPER1

GO Terms for genes affiliated with Male Infertility

Sources:
16Gene Ontology
See all sources

Cellular components related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CatSper complexGO:03612810.6CATSPER2, CATSPER1

Biological processes related to Male Infertility according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:00728311.2OAZ3, BPY2C, CATSPER1, CATSPER2, UBE2B, FKBP6
2single fertilizationGO:00733810.8CATSPER2, CATSPER1, BPY2C
3cell differentiationGO:03015410.7DAZ3, DAZ1, CATSPER2, CATSPER1
4sperm-egg recognitionGO:03503610.7CATSPER2, CATSPER1
5ciliary or bacterial-type flagellar motilityGO:00153910.7CATSPER1, CATSPER2
6sperm motilityGO:03031710.6CATSPER2, CATSPER1
7multicellular organism reproductionGO:03250410.5CATSPER1, CATSPER2
8multicellular organismal developmentGO:00727510.4DAZ3, DAZ1, CATSPER2, CATSPER1

Molecular functions related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:00372310.7DAZ3, DAZ1, DDX3Y, RBMXL2

Products for genes affiliated with Male Infertility

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Sources for Male Infertility

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet