Aliases & Classifications for Male Infertility

MalaCards integrated aliases for Male Infertility:

Name: Male Infertility 38 12 29 41 14 69
Infertility, Male 42
Infertility Male 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12336
ICD10 33 N46 N46.9
ICD9CM 35 606 606.9
MeSH 42 D007248
UMLS 69 C0021364

Summaries for Male Infertility

MedlinePlus : 41 infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. causes of male infertility include physical problems with the testicles blockages in the ducts that carry sperm hormone problems a history of high fevers or mumps genetic disorders lifestyle or environmental factors about a third of the time, infertility is because of a problem with the man. one third of the time, it is a problem with the woman. sometimes no cause can be found. if you suspect you are infertile, see your doctor. there are tests that may tell if you have fertility problems. when it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technology. happily, many couples treated for infertility are able to have babies. nih: national institute of child health and human development

MalaCards based summary : Male Infertility, also known as infertility, male, is related to catsper1-related nonsyndromic male infertility and catsper-related male infertility, and has symptoms including subfertility, male, inability to conceive due to male infertility and inability to impregnate. An important gene associated with Male Infertility is DAZ1 (Deleted In Azoospermia 1). The drugs Metformin and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include Testis and Testis, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 72 Male infertility refers to a male\'s inability to cause pregnancy in a fertile female. In humans it... more...

Related Diseases for Male Infertility

Diseases related to Male Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
id Related Disease Score Top Affiliating Genes
1 catsper1-related nonsyndromic male infertility 12.3
2 catsper-related male infertility 12.2
3 non-syndromic male infertility due to sperm motility disorder 12.2
4 rare idiopathic male infertility 12.1
5 male infertility with spermatogenesis disorder 12.0
6 male infertility with spermatogenesis disorder due to single gene mutation 12.0
7 male infertility with teratozoospermia due to single gene mutation 12.0
8 spermatogenic failure 6 11.9
9 spermatogenic failure 5 11.9
10 deafness-infertility syndrome 11.7
11 macrozoospermia 11.5
12 azoospermia 11.2
13 spermatogenic failure 7 11.1
14 cystic fibrosis 11.1
15 oligospermia 11.1
16 infertility 11.0
17 spermatogenic failure, x-linked, 2 11.0
18 spermatogenic failure 17 11.0
19 young syndrome 10.9
20 spermatogenic failure 16 10.7
21 glucocorticoid resistance 10.7
22 ciliary dyskinesia, primary, 18 10.7
23 spermatogenic failure, y-linked, 1 10.7
24 spermatogenic failure, y-linked, 2 10.7
25 ciliary dyskinesia, primary, 34 10.7
26 spermatogenic failure 21 10.7
27 spermatogenic failure 9 10.7
28 spermatogenic failure 14 10.7
29 sertoli cell-only syndrome 10.7
30 spermatogenic failure 18 10.7
31 ciliary dyskinesia, primary, 22 10.7
32 spermatogenic failure 13 10.7
33 10q22.3q23 microdeletion syndrome 10.4 DAZ1 DAZL DDX3Y USP9Y
34 retinitis pigmentosa, y-linked 10.3 DAZ1 DAZ2 DAZ3 DAZ4 USP9Y
35 severe congenital neutropenia 10.3 DAZ1 DDX3Y USP26 USP9Y
36 internal hemorrhoid 10.2 PRM1 PRM2
37 nephronophthisis-like nephropathy 1 10.2 DAZ1 DAZL USP9Y
38 passos-bueno syndrome 10.2 DAZ1 DAZ2 DAZ3 DAZ4 DDX3Y USP9Y
39 varicocele 10.2
40 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.1 AR DAZ1 DAZ4
41 gastrointestinal tularemia 10.1 AR CFTR DAZ1 DAZ4
42 prostatitis 10.0
43 cryptorchidism 10.0
44 chlamydia 9.9
45 congenital adrenal hyperplasia 9.8
46 hypogonadism 9.8
47 obesity 9.8
48 inguinal hernia 9.8
49 orchitis 9.8
50 thyroiditis 9.8

Graphical network of the top 20 diseases related to Male Infertility:



Diseases related to Male Infertility

Symptoms & Phenotypes for Male Infertility

UMLS symptoms related to Male Infertility:


subfertility, male, inability to conceive due to male infertility, inability to impregnate

GenomeRNAi Phenotypes related to Male Infertility according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.98 BPY2C EPPIN BPY2 BPY2B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 EPPIN BPY2 BPY2B BPY2C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.98 EPPIN
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.98 EPPIN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.98 EPPIN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.98 BPY2 BPY2B BPY2C
7 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.98 BPY2C BPY2 BPY2B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.98 EPPIN
9 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.98 EPPIN
10 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.98 BPY2C BPY2 BPY2B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.98 BPY2C BPY2 BPY2B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.98 EPPIN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.98 EPPIN
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.83 EPPIN
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.83 BPY2 BPY2B BPY2C
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.83 EPPIN
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.83 BPY2 BPY2B BPY2C EPPIN
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.83 EPPIN
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.83 EPPIN
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.83 BPY2 BPY2B BPY2C
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.83 EPPIN

Drugs & Therapeutics for Male Infertility

Drugs for Male Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 418)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 2 657-24-9 14219 4091
2
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
3
Ganirelix Approved Phase 4,Phase 3,Phase 2 123246-29-7, 124904-93-4 25081094
4
Diazepam Approved, Illicit, Vet_approved Phase 4 439-14-5 3016
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
6
Meperidine Approved Phase 4 57-42-1 4058
7
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
8
Cetrorelix Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 120287-85-6 16129715 25074887
9
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757
10
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112809-51-5 3902
11
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Early Phase 1 50-02-2 5743
12
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 3911 657181
13
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6 772 46507594
14
Menotropins Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 61489-71-2, 9002-68-0 5360545
15
Buserelin Approved Phase 4,Phase 3 57982-77-1
16
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3 137-58-6 3676
17
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
18
Methyltestosterone Approved Phase 4,Phase 3,Phase 2 58-18-4 6010
19
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2 58-22-0 6013
20
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
21
Tamoxifen Approved Phase 4,Phase 3 10540-29-1 2733526
22
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3 71-58-9
23
Desogestrel Approved Phase 4 54024-22-5 40973
24
Ethinyl Estradiol Approved Phase 4,Phase 1 57-63-6 5991
25
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
26
Nafarelin Approved Phase 4 76932-56-4 16129618 25077649
27
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
28
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
29
Dalteparin Approved Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6
30
Pentoxifylline Approved, Investigational Phase 4,Phase 3 6493-05-6 4740
31
Dopamine Approved Phase 4,Phase 2,Phase 3 51-61-6, 62-31-7 681
32
Norepinephrine Approved Phase 4 51-41-2 439260
33
Dienogest Approved Phase 4 65928-58-7
34
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
35
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
36
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
37
Estrone Approved Phase 4 53-16-7 5870
38
Ticlopidine Approved Phase 4 55142-85-3 5472
39
Trimethobenzamide Approved Phase 4 138-56-7 5577
40
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
42
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
43
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
44
Dehydroepiandrosterone Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Early Phase 1 53-43-0 9860744
45
Ginseng Approved, Nutraceutical Phase 4 50647-08-0
46
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Early Phase 1 50-14-6 5280793
47
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 1406-16-2
48
Calcitriol Approved, Nutraceutical Phase 4,Phase 2 32222-06-3 134070 5280453
49
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
50
Enclomiphene Investigational Phase 4,Phase 2,Phase 3,Phase 1 15690-57-0

Interventional clinical trials:

(show top 50) (show all 1080)

id Name Status NCT ID Phase Drugs
1 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
2 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
3 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
4 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4 Luteal support with progesterone only;Luteal support with estrogen + progesterone
5 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4 75IU uFSH
6 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
7 Biosimilar Versus Urinary Gonadotropins Unknown status NCT02503605 Phase 4 Biosimilar recombinant FSH;Urinary FSH
8 Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation Unknown status NCT00417183 Phase 4 Arvekap 0.1 mg (Triptorelin, Ipsen, France);Ganirelix 0.25 (Orgalutran, Organon, The Netherlands)
9 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4 Human Chorionic Gonadotropin (HCG)
10 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4 Metformin, gonadotropins in step-down regimen;Placebo, gonadotropins in step-up regimen
11 A Non-inferiority Trial on Pain Relief During Oocyte Retrieval Unknown status NCT02494180 Phase 4 fentanyl;pethidine;Diazepam;Midazolam
12 Corifollitropin Alfa Versus Follitropin Beta in High Responders Unknown status NCT02471677 Phase 4 Elonva;Puregon
13 Type of Gonadotropin and Embryo Kinetics of Development Unknown status NCT02402192 Phase 4 Corifollitropin alfa
14 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial. Unknown status NCT01992731 Phase 4
15 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
16 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4 Placebo;Dexamethasone
17 Intrauterine Insemination and Luteal Fase Support Unknown status NCT01826747 Phase 4 crinone (progesterone 8%, vaginal application)
18 Study of Dual Trigger Ovulation in Oocyte Donors Unknown status NCT01443546 Phase 4 HCG;Lupron Trigger;Dual Trigger
19 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4 Agonist GnRH; estradiol Valerate; progesterone
20 Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs Unknown status NCT00415792 Phase 4 Arvekap, Pregnyl
21 The Effect of LH-Priming During Early Follicular Phase in IVF Treatment. Unknown status NCT00334425 Phase 4 MENOPUR; GONAL-F
22 Use of Corifolitropin Alfa in Oocyte Donors Unknown status NCT02213627 Phase 4 Corifollitropin alfa;Recombinant FSH;HP-hMG
23 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4 Korean Red Ginseng (KRG)
24 Effects of Korean Red Ginseng on Male Infertility Completed NCT02202382 Phase 4 Korean Red Ginseng, Varicocelectomy;Placebo
25 Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4 Recombinant LH (Luveris)
26 Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial Completed NCT01463787 Phase 4
27 Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing In Vitro Fertilization Cycles Completed NCT01560065 Phase 4
28 Sexual Absorption of Vaginal Progesterone Completed NCT01959464 Phase 4 Crinone vaginal progesterone gel;Placebo vaginal gel
29 Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome Completed NCT01675843 Phase 4
30 Observational Study of Male Circumcision Using PrePex Device Completed NCT01711411 Phase 4
31 The Role of Massage in Increasing Total Motile Sperm Count of IUI Completed NCT01969825 Phase 4
32 A Prospective Field Study: Introducing the Shang Ring in Routine Clinical Settings Completed NCT01567436 Phase 4
33 Safety and Acceptability of the PrePex™ Device for Male Circumcision in Zambia Completed NCT01844102 Phase 4
34 Role of Laparoscopy in Unexplained Infertility Completed NCT00886041 Phase 4
35 The Effect of LMWH on ICSI in Patients With Unexplained Infertility and Negative Immunological Markers Completed NCT02861105 Phase 4 LMWH
36 Endometrial Shedding Prior to Ovulation Induction Pilot Study Completed NCT02340013 Phase 4 Medroxyprogesterone acetate
37 Efficacy and Safety of R-hLH (Luveris ®) Priming Prior to R-HFSH Treatment in Infertile Women Undergoing IVF-ET Completed NCT00441324 Phase 4
38 Multicenter, Randomized, Open Label, Parallel Study to Evaluate the Efficacy & Safety of IVF-M HP Inj. vs. Menopur® Inj. Completed NCT02458768 Phase 4 IVF-M HP Inj.;Menopur® Inj.
39 Luteal Phase FSH in the IVF Poor Responder Completed NCT00225433 Phase 4 follitropin beta;ganirelix acetate
40 Dosage Optimization for Letrozole Treatment Completed NCT01315912 Phase 4 Letrozole
41 Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development Completed NCT00993902 Phase 4
42 Low Dose hCG in the Late Follicular Phase Completed NCT00750100 Phase 4 human chorionic gonadotropin;recombinant gonadotropins
43 Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol Completed NCT01419353 Phase 4 estradiol valerate
44 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed NCT00621179 Phase 4 Leuprolide acetate in depot suspension;Leuprolide acetate;leuprolide acetate
45 Efficacy of Embryo Transfer Procedure Guided by Transvaginal Ultrasound Versus Abdominal Ultrasound in Oocytes Recipients Completed NCT01137461 Phase 4
46 Tolerability and Satisfaction With Evie Completed NCT01969812 Phase 4
47 MENOPUR® Versus FOLLISTIM® Completed NCT00802360 Phase 4 Menotropin;Progestrone vaginal insert;follitropin beta;Progesterone in oil;Ganirelix
48 Perifollicular Vascularity Assessment in in-Vitro Fertilization Completed NCT00458380 Phase 4
49 The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With Endometriosis Completed NCT01581359 Phase 4 Triptorelin acetate
50 CONSORT Randomized Controlled Trial in Assisted Reproductive Technology Completed NCT00829244 Phase 4 GONAL f® prefilled pen;GONAL f® prefilled pen

Search NIH Clinical Center for Male Infertility

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: infertility, male

Genetic Tests for Male Infertility

Genetic tests related to Male Infertility:

id Genetic test Affiliating Genes
1 Male Infertility 29

Anatomical Context for Male Infertility

MalaCards organs/tissues related to Male Infertility:

39
Testes, Prostate, Testis, Uterus, Ovary, Pituitary, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Male Infertility:
id Tissue Anatomical CompartmentCell Relevance
1 Testis Seminiferous Tubules Elongated Spermatid Affected by disease
2 Testis Seminiferous Tubules Spermatid Affected by disease
3 Testis Seminiferous Tubules Spermatozoan Affected by disease

Publications for Male Infertility

Articles related to Male Infertility:

(show top 50) (show all 892)
id Title Authors Year
1
TTY2 genes deletions as genetic risk factor of male infertility. ( 28364784 )
2017
2
The effects of tomato juice on male infertility. ( 28049263 )
2017
3
Male infertility - The other side of the equation. ( 28892594 )
2017
4
Prevalence and management of incidental small testicular masses discovered on ultrasonographic evaluation of male infertility. ( 28789946 )
2017
5
Biallelic Mutations in CFAP43 and CFAP44 Cause Male Infertility with Multiple Morphological Abnormalities of the Sperm Flagella. ( 28552195 )
2017
6
Varicocele and male infertility. ( 28675168 )
2017
7
Role of Glutathione-S-Transferase Family Genes in Male Infertility. ( 28944422 )
2017
8
Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCIP. ( 28270562 )
2017
9
Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility. ( 28797078 )
2017
10
Fluorescence in situ hybridisation sperm examination is significantly impaired in all categories of male infertility. ( 28762516 )
2017
11
Idiopathic male infertility related to periodontal and caries status. ( 28746727 )
2017
12
Comparative analysis of testis transcriptomes associated with male infertility in cattleyak. ( 27865410 )
2017
13
Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China: A STROBE-compliant article. ( 28796064 )
2017
14
Ubiquitination-deficient mutations in human Piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis. ( 28552346 )
2017
15
Office-based andrology and male infertility procedures-a cost-effective alternative. ( 28904909 )
2017
16
Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation. ( 28476888 )
2017
17
Re: Causes of Male Infertility: A 9-Year Prospective Monocentre Study on 1737 Patients with Reduced Total Sperm Counts. ( 28817890 )
2017
18
Associations between male infertility and ancestry in South Americans: a case control study. ( 28747152 )
2017
19
The role of microsurgical varicocelectomy in treating male infertility. ( 28904905 )
2017
20
Male Infertility Associated with a Supernumerary Marker Chromosome. ( 28879694 )
2017
21
Increased Total mtDNA Copy Number Cures Male Infertility Despite Unaltered mtDNA Mutation Load. ( 28768180 )
2017
22
Genetic polymorphisms and haplotypes of the DJ-1 gene promoter associated with the susceptibility to male infertility. ( 28932933 )
2017
23
Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Male Infertility in Asian Population. ( 28811683 )
2017
24
Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis. ( 28397035 )
2017
25
Mutations in the prostate specific antigen (PSA/KLK3) correlate with male infertility. ( 28894123 )
2017
26
Ggnbp2-Null Mutation in Mice Leads to Male Infertility Due to a Defect at the Spermiogenesis Stage. ( 28823874 )
2017
27
MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis. ( 28081209 )
2017
28
Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. ( 27864361 )
2017
29
Effect of Chinese Herbal Medicine on Male Infertility. ( 28807164 )
2017
30
The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis. ( 28050928 )
2017
31
Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. ( 28894282 )
2017
32
Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress. ( 28933362 )
2017
33
In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility. ( 27802063 )
2017
34
Phylogenetic and population-based approaches to mitogenome variation do not support association with male infertility. ( 27904151 )
2016
35
TDRP deficiency contributes to low sperm motility and is a potential risk factor for male infertility. ( 27069551 )
2016
36
Genetics of Male Infertility. ( 27502429 )
2016
37
Ureaplasma urealyticum in male genital tract: a hidden risk factor for male infertility. ( 27897333 )
2016
38
Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility. ( 27973917 )
2016
39
Oxidative stress and the etiology of male infertility. ( 27544275 )
2016
40
Re: The "Omics" of Human Male Infertility: Integrating Big Data in a Systems Biology Approach. ( 27628827 )
2016
41
Male infertility-related molecules involved in sperm-oocyte fusion. ( 27904014 )
2016
42
Deficiency in Outer Dense Fiber 1 Is a Marker and Potential Driver of Idiopathic Male Infertility. ( 27770032 )
2016
43
Genetic factors contributing to human primary ciliary dyskinesia and male infertility. ( 27270341 )
2016
44
Recent advances in understanding & managing male infertility. ( 27990271 )
2016
45
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. ( 27486783 )
2016
46
Research trends and perspectives of male infertility: a bibliometric analysis of 20A years of scientific literature. ( 27389996 )
2016
47
Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. ( 27035939 )
2016
48
Insurance coverage for male infertility care in the United States. ( 27030084 )
2016
49
Impact of CAG repeat length in the androgen receptor gene on male infertility - a meta-analysis. ( 27157932 )
2016
50
Male infertility in mice lacking the store-operated Ca(2+) channel Orai1. ( 26969191 )
2016

Variations for Male Infertility

ClinVar genetic disease variations for Male Infertility:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Pathogenic/Likely pathogenic rs200750564 GRCh37 Chromosome 2, 176959246: 176959246

Expression for Male Infertility

Search GEO for disease gene expression data for Male Infertility.

Pathways for Male Infertility

GO Terms for Male Infertility

Cellular components related to Male Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 AR BPY2 BPY2B BPY2C DAZ1 DAZ2
2 chromosome GO:0005694 9.46 H2BFWT PRM1 PRM2 TNP2
3 nucleosome GO:0000786 9.13 H2BFWT PRM1 PRM2

Biological processes related to Male Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.85 BOLL CATSPER2 DAZ1 DAZ2 DAZ3 DAZ4
2 protein deubiquitination GO:0016579 9.71 AR CFTR USP26 USP9Y
3 single fertilization GO:0007338 9.65 AR BPY2 BPY2B BPY2C DAZ2
4 spermatogenesis GO:0007283 9.5 AR BOLL BPY2 BPY2B BPY2C CATSPER2
5 chromosome condensation GO:0030261 9.43 PRM1 PRM2
6 DNA packaging GO:0006323 9.37 PRM1 PRM2
7 positive regulation of translational initiation GO:0045948 9.13 BOLL DAZ1 DAZL
8 multicellular organism development GO:0007275 10.02 BOLL CATSPER2 DAZ1 DAZ2 DAZ3 DAZ4

Molecular functions related to Male Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.8 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
2 HECT domain binding GO:0032399 9.33 BPY2 BPY2B BPY2C
3 translation activator activity GO:0008494 8.8 BOLL DAZ1 DAZL
4 mRNA 3-UTR binding GO:0003730 8.65 DAZL

Sources for Male Infertility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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