MCID: MLN007
MIFTS: 58

Male Infertility malady

Genetic diseases (common), Reproductive diseases categories
Download this MalaCard

Summaries for Male Infertility

About this section
Sources:
34MedlinePlus, 65Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard
MedlinePlus:34 Infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. causes of male infertility include physical problems with the testicles blockages in the ducts that carry sperm hormone problems a history of high fevers or mumps genetic disorders lifestyle or environmental factors about a third of the time, infertility is because of a problem with the man. one third of the time, it is a problem with the woman. sometimes no cause can be found. if you suspect you are infertile, see your doctor. there are tests that may tell if you have fertility problems. when it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technologies. happily, two-thirds of couples treated for infertility are able to have babies. nih: national institute of child health and human development

MalaCards: Male Infertility, also known as infertility, male, is related to infertility and azoospermia. An important gene associated with Male Infertility is UBE2B (ubiquitin-conjugating enzyme E2B), and among its related pathways is Reproduction. The drugs clomiphene and clomiphene citrate and the compounds pgf1alpha and nnc55-0396 have been mentioned in the context of this disorder. Affiliated tissues include testes, testis and prostate.

Wikipedia:65 Male infertility refers to a male\'s inability to cause pregnancy in a fertile female. In humans it... more...

Aliases & Classifications for Male Infertility

About this section
Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 34MedlinePlus, 62UMLS, 22GTR, 45Novoseek, 35MeSH, 58SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Reproductive diseases


Aliases & Descriptions:

male infertility 8 47 10 34 62
infertility, male 8 22
male infertility, unspecified 8
male infertility nos 8
infertility male 45


External Ids:

Disease Ontology8 DOID:12336
MeSH35 D007248
ICD9CM27 606.9, 606
ICD1025 Q98.6, Q98.7

Related Diseases for Male Infertility

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Male Infertility family:

Catsper1-Related Nonsyndromic Male Infertility

Diseases related to Male Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1infertility32.1EPPIN, USP26, AZF1
2azoospermia30.8DDX3Y, AZF1, USP26, H2BFWT, FKBP6
3oligospermia30.5AZF1, DDX3Y
4sertoli cell-only syndrome30.1DDX3Y
5varicocele10.6
6prostatitis10.4
7deafness-infertility syndrome10.4
8catsper1-related nonsyndromic male infertility10.4
9cryptorchidism10.4
10klinefelter's syndrome10.4
11catsper-related male infertility10.4
12cystic fibrosis10.3
13congenital adrenal hyperplasia10.3
14obesity10.3
15deafness and male infertility10.3
16orchitis10.3
17hypogonadism10.3
18spermatogenic failure 710.3
19spermatogenic failure 1310.3
20male infertility with teratozoospermia due to single gene mutation10.3
2121-hydroxylase deficiency10.2
22adrenal rest tumor10.2
23spermatocele10.2
24polycystic kidney disease10.2
25hydrocephalus10.2
26impotence10.2
27kidney disease10.2
28prostate cancer10.2
29thyroiditis10.2
30spermatogenic failure 510.2
31spermatogenic failure 610.2
32catsper-related nonsyndromic male infertility10.2
33spinal cord injury10.2
34testicular microlithiasis10.2
35male infertility due to acrosin deficiency10.2
36epididymitis10.2
37vesiculitis10.2
38y chromosome infertility10.0DDX3Y
39urethritis10.0
40panhypopituitarism10.0
41primary ciliary dyskinesia10.0
42urethral diverticulum10.0
43situs inversus10.0
44morbid obesity10.0
45imperforate anus10.0
46hypogonadotropism10.0
47addison's disease10.0
48teratocarcinoma10.0
49hyperprolactinemia10.0
50hydronephrosis10.0

Graphical network of the top 20 diseases related to Male Infertility:



Diseases related to male infertility

Symptoms for Male Infertility

About this section

Drugs & Therapeutics for Male Infertility

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Male Infertility

Search NIH Clinical Center for Male Infertility

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Male Infertility

About this section
Sources:
22GTR
See all sources

Genetic tests related to Male Infertility:

id Genetic test Affiliating Genes
1 Male Infertility22

Anatomical Context for Male Infertility

About this section
Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Male Infertility:

33
Testes, Testis, Prostate, Spinal cord, Kidney, Thyroid, Eye, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Male Infertility:
id TissueAnatomical CompartmentCell Relevance
1 TestisSeminiferous TubulesElongated Spermatid Affected by disease
2 TestisSeminiferous TubulesSpermatid Affected by disease
3 TestisSeminiferous TubulesSpermatozoan Affected by disease

Animal Models for Male Infertility or affiliated genes

About this section

Publications for Male Infertility

About this section
Sources:
52PubMed
See all sources

Articles related to Male Infertility:

(show top 50)    (show all 688)
idTitleAuthorsYear
1
The field of male infertility moves fast! (24286780)
2014
2
Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. (23512232)
2013
3
The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility. (23415969)
2013
4
Reproductive outcomes in patients with male infertility because of Klinefelter's syndrome, Kartagener's syndrome, round-head sperm, dysplasia fibrous sheath, and 'stump' tail sperm: an updated literature review. (23587797)
2013
5
No CAG repeat expansion of polymerase gamma is associated with male infertility in Tamil Nadu, South India. (24339545)
2013
6
Association of the gonadotrophin-regulated testicular RNA helicase gene polymorphism with human male infertility. (24168058)
2013
7
Occupational causes of male infertility. (23422246)
2013
8
The utility and cost of Chlamydia trachomatis and Neisseria gonorrhoeae screening of a male infertility population. (22192351)
2012
9
Association between the JC polyomavirus infection and male infertility. (22912758)
2012
10
Focus issue on male infertility. (22190920)
2012
11
Higher proportion of haploid round spermatids and spermatogenic disomy rate in relation to idiopathic male infertility. (21094989)
2011
12
Antioxidant therapy in male infertility: fact or fiction? (21516118)
2011
13
Testicular failure and male infertility in the monogenic Mulibrey nanism disorder. (21865362)
2011
14
Evaluating the role of the FSH receptor gene Thr307-Ala and Asn680-Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones. (21105990)
2011
15
Male infertility: pathogenesis and clinical diagnosis. (21397198)
2011
16
Assessment of the level of trace element zinc in seminal plasma of males and evaluation of its role in male infertility. (23776785)
2011
17
Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1. (20887963)
2010
18
Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. (20845296)
2010
19
Study on the relationship between partial deletions in the azzospermia factor C region of Y chromosome and male infertility]. (20533269)
2010
20
Biology of spermatogenesis and male infertility. (20536319)
2010
21
Robotic surgery in male infertility and chronic orchialgia. (19887946)
2010
22
Association of male infertility with (CAG)n polymorphism of the androgen receptor gene: a meta-analysis]. (19947564)
2009
23
Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. (19517319)
2009
24
Mitochondrial DNA mutations and male infertility. (21088712)
2009
25
Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility. (18823884)
2009
26
Male infertility associated with adult dominant polycystic kidney disease: a case series. (19137444)
2009
27
Hormonal treatment of male infertility: promises and pitfalls. (18930905)
2009
28
Use of the aromatase inhibitor letrozole to treat male infertility. (19524225)
2009
29
The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice. (19884658)
2009
30
Male infertility in the era of ART: why treat; how to treat. (19247911)
2009
31
Association of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility. (19815951)
2009
32
Antioxidant therapy in male infertility. (18423251)
2008
33
Families of two: meeting the needs of couples experiencing male infertility. (18715377)
2008
34
Trials of antioxidants for male infertility. (18275588)
2008
35
Autosomal DAZL single nucleotide polymorphisms not associated with male infertility in northeast China]. (17918711)
2007
36
Association between the apolipoprotein B signal peptide gene insertion/deletion polymorphism and male infertility. (17071710)
2006
37
Male infertility: no evidence of involvement of androgen receptor gene among Indian men. (16400085)
2006
38
Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development. (16923965)
2006
39
Molecular evaluation of CFTR sequence variants in male infertility of testicular origin. (16128988)
2005
40
Molecular pathology of the CFTR locus in male infertility. (15705292)
2005
41
Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. (15340058)
2004
42
Idiopathic cases of male infertility from a region in India show low incidence of Y-chromosome microdeletion. (14517364)
2003
43
Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility. (12724276)
2003
44
CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations. (12399527)
2002
45
Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. (11994405)
2002
46
The cystic fibrosis transmembrane regulator gene and male infertility. (11097434)
2000
47
Y chromosome and male infertility]. (9644848)
1998
48
Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. (9360540)
1997
49
A study on intratesticular aromatase activity in male infertility]. (7776564)
1995
50
Chronic prostato-vesiculitis and sperm-cell mobility in male infertility. (696189)
1978

Variations for Male Infertility

About this section

Expression for genes affiliated with Male Infertility

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Male Infertility

Search GEO for disease gene expression data for Male Infertility.

Pathways for genes affiliated with Male Infertility

About this section
Sources:
50PathCards, 55Reactome
See all sources

Pathways related to Male Infertility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CATSPER1, CATSPER2

Compounds for genes affiliated with Male Infertility

About this section
Sources:
29IUPHAR, 45Novoseek, 11DrugBank
See all sources

Compounds related to Male Infertility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pgf1alpha299.8CATSPER1, CATSPER2
2nnc55-0396299.8CATSPER1, CATSPER2
3mibefradil45 29 1111.8CATSPER1, CATSPER2
4pge1299.7CATSPER2, CATSPER1
5pge2299.5CATSPER1, CATSPER2

GO Terms for genes affiliated with Male Infertility

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CatSper complexGO:0361289.8CATSPER1, CATSPER2

Biological processes related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1multicellular organism reproductionGO:0325049.8CATSPER1, CATSPER2
2sperm-egg recognitionGO:0350369.5CATSPER1, CATSPER2
3single fertilizationGO:0073389.0BPY2C, CATSPER2, CATSPER1
4spermatogenesisGO:0072838.6UBE2B, CATSPER1, CATSPER2, BPY2C, FKBP6

Products for genes affiliated with Male Infertility

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Male Infertility

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet