Aliases & Classifications for Male Infertility

MalaCards integrated aliases for Male Infertility:

Name: Male Infertility 37 12 28 40 14 69
Infertility, Male 41
Infertility Male 51

Classifications:



External Ids:

Disease Ontology 12 DOID:12336
ICD10 32 N46 N46.9
ICD9CM 34 606 606.9
MeSH 41 D007248
UMLS 69 C0021364

Summaries for Male Infertility

MedlinePlus : 40 Infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. Causes of male infertility include Physical problems with the testicles Blockages in the ducts that carry sperm Hormone problems A history of high fevers or mumps Genetic disorders Lifestyle or environmental factors About a third of the time, infertility is because of a problem with the man. One third of the time, it is a problem with the woman. Sometimes no cause can be found. If you suspect you are infertile, see your doctor. There are tests that may tell if you have fertility problems. When it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technology. Happily, many couples treated for infertility are able to have babies. NIH: National Institute of Child Health and Human Development

MalaCards based summary : Male Infertility, also known as infertility, male, is related to spermatogenic failure, x-linked, 1 and spermatogenic failure, y-linked, 2, and has symptoms including inability to impregnate, inability to conceive due to male infertility and subfertility, male. An important gene associated with Male Infertility is DAZ1 (Deleted In Azoospermia 1). The drugs Metformin and Folic Acid have been mentioned in the context of this disorder. Affiliated tissues include Testis and Testis, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Male infertility refers to a male\'s inability to cause pregnancy in a fertile female. In humans it... more...

Related Diseases for Male Infertility

Diseases related to Male Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 spermatogenic failure, x-linked, 1 31.4 DAZ1 DAZ4 DAZL DDX3Y USP26 USP9Y
2 spermatogenic failure, y-linked, 2 31.2 BPY2 DAZ1 DAZ2 DAZ3 DAZ4 DDX3Y
3 azoospermia 30.8 AR BOLL CFTR DAZ1 DAZ2 DAZ3
4 infertility 30.7 CATSPER2 DAZ1 DAZ3 DAZ4 DAZL DDX3Y
5 oligospermia 29.7 AR CFTR DAZ1 DAZ4
6 catsper1-related nonsyndromic male infertility 12.4
7 non-syndromic male infertility due to sperm motility disorder 12.3
8 catsper-related male infertility 12.3
9 rare idiopathic male infertility 12.2
10 spermatogenic failure 6 12.1
11 male infertility with spermatogenesis disorder 12.1
12 male infertility with spermatogenesis disorder due to single gene mutation 12.1
13 male infertility with teratozoospermia due to single gene mutation 12.1
14 spermatogenic failure 5 12.0
15 deafness-infertility syndrome 11.9
16 macrozoospermia 11.7
17 spermatogenic failure 7 11.3
18 spermatogenic failure, x-linked, 2 11.2
19 spermatogenic failure 17 11.2
20 cystic fibrosis 11.2
21 young syndrome 11.0
22 spermatogenic failure, y-linked, 1 10.8
23 spermatogenic failure 9 10.8
24 ciliary dyskinesia, primary, 18 10.8
25 ciliary dyskinesia, primary, 22 10.8
26 spermatogenic failure 13 10.8
27 spermatogenic failure 14 10.8
28 glucocorticoid resistance, generalized 10.8
29 ciliary dyskinesia, primary, 34 10.8
30 spermatogenic failure 16 10.8
31 spermatogenic failure 18 10.8
32 spermatogenic failure 21 10.8
33 varicocele 10.2
34 partial deletion of y 10.1 DAZ1 DAZ2 DAZ3 DAZ4 DDX3Y USP9Y
35 prostatitis 10.1
36 cryptorchidism, unilateral or bilateral 10.0
37 hypogonadotropic hypogonadism 10.0
38 chlamydia 10.0
39 phelan-mcdermid syndrome 10.0 DAZ1 DAZL USP9Y
40 fibrosis of extraocular muscles, congenital, 1 10.0
41 lipoid congenital adrenal hyperplasia 10.0
42 body mass index quantitative trait locus 11 9.9
43 body mass index quantitative trait locus 9 9.9
44 body mass index quantitative trait locus 8 9.9
45 body mass index quantitative trait locus 4 9.9
46 body mass index quantitative trait locus 10 9.9
47 body mass index quantitative trait locus 7 9.9
48 body mass index quantitative trait locus 12 9.9
49 body mass index quantitative trait locus 14 9.9
50 body mass index quantitative trait locus 18 9.9

Graphical network of the top 20 diseases related to Male Infertility:



Diseases related to Male Infertility

Symptoms & Phenotypes for Male Infertility

UMLS symptoms related to Male Infertility:


inability to impregnate, inability to conceive due to male infertility, subfertility, male

GenomeRNAi Phenotypes related to Male Infertility according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.58 BPY2C BPY2 BPY2B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.58 BPY2 BPY2B BPY2C
3 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.58 BPY2C BPY2 BPY2B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.58 BPY2C BPY2 BPY2B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.58 BPY2 BPY2B BPY2C
6 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.58 BPY2C BPY2 BPY2B

Drugs & Therapeutics for Male Infertility

Drugs for Male Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 186)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 4091 14219
2
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2 59-30-3 6037
3
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
4
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 77-92-9 311
5
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2 58-05-9 143 6006
6
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
7
Enclomiphene Investigational Phase 4,Phase 2,Phase 3,Phase 1 15690-57-0
8 Antioxidants Phase 4,Phase 3,Phase 2,Early Phase 1
9 Central Nervous System Depressants Phase 4,Phase 2
10 Follicle Stimulating Hormone Phase 4,Phase 3,Phase 2
11 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
12 Hormones Phase 4,Phase 3,Phase 2,Phase 1
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
14 Micronutrients Phase 4,Phase 3,Phase 2,Early Phase 1
15 Protective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
16 Trace Elements Phase 4,Phase 3,Phase 2,Early Phase 1
17 Vitamin B Complex Phase 4,Phase 3,Phase 2
18 Vitamins Phase 4,Phase 3,Phase 2,Early Phase 1
19 Anticoagulants Phase 4,Phase 2,Phase 3
20 Calcium, Dietary Phase 4,Phase 2,Phase 3
21 Chelating Agents Phase 4,Phase 2,Phase 3
22 Chorionic Gonadotropin Phase 4,Phase 2
23 Clomiphene Phase 4,Phase 2,Phase 3,Phase 1
24 Estrogen Antagonists Phase 4,Phase 3,Phase 2,Phase 1
25 Estrogen Receptor Modulators Phase 4,Phase 2,Phase 3,Phase 1
26 Estrogens Phase 4,Phase 3,Phase 2,Phase 1
27 Fertility Agents Phase 4,Phase 2,Phase 3,Phase 1
28 Hypoglycemic Agents Phase 4
29 insulin Phase 4
30 Insulin, Globin Zinc Phase 4
31 Selective Estrogen Receptor Modulators Phase 4,Phase 2,Phase 3,Phase 1
32 Zuclomiphene Phase 4,Phase 2,Phase 3,Phase 1
33 Hematinics Phase 4,Phase 3
34 Folate Nutraceutical Phase 4,Phase 3,Phase 2
35 Inositol Nutraceutical Phase 4
36 Vitamin B9 Nutraceutical Phase 4,Phase 3,Phase 2
37 Citrate Nutraceutical Phase 4,Phase 2,Phase 3
38
Letrozole Approved, Investigational Phase 3 112809-51-5 3902
39
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
40
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
41
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
42
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
43
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
44
Procarbazine Approved, Investigational Phase 3 671-16-9 4915
45
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
46
Methyltestosterone Approved Phase 3,Phase 2 58-18-4 6010
47
Testosterone Approved, Investigational Phase 3,Phase 2 58-22-0 6013
48
Estradiol Approved, Investigational, Vet_approved Phase 3 50-28-2 5757
49
Menthol Approved Phase 3 2216-51-5 16666
50
Anastrozole Approved, Investigational Phase 3 120511-73-1 2187

Interventional clinical trials:

(show top 50) (show all 109)

# Name Status NCT ID Phase Drugs
1 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
2 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4 Recombinant FSH (rFSH)
3 Role of FSHR Polymorphism p.N680S in the Therapy With FSH in Patients Who Underwent Varicocele Surgery Unknown status NCT02719093 Phase 4 recombinant FSH
4 Metformin for the Treatment of Unexplained Oligozspermia Unknown status NCT01529177 Phase 4 Metformin / clomid / hCG;Clomiphene citrate / hCG
5 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4 Korean Red Ginseng (KRG)
6 Effects of Korean Red Ginseng on Male Infertility Completed NCT02202382 Phase 4 Korean Red Ginseng, Varicocelectomy;Placebo
7 Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4 Recombinant LH (Luveris)
8 Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial Completed NCT01463787 Phase 4
9 Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing In Vitro Fertilization Cycles Completed NCT01560065 Phase 4
10 Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility. Unknown status NCT01918163 Phase 3
11 FSH Treatment for Non-obstructive Azoospermic Patients Unknown status NCT02275169 Phase 3 Urofollitropin
12 Spermotrend in the Treatment of Male Infertility Completed NCT00975117 Phase 3
13 Impact of Folates in the Care of the Male Infertility Completed NCT01407432 Phase 3 Folic acid;placebo of folic acid
14 Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial Completed NCT01304927 Phase 2, Phase 3 Cholecalciferol and calcium
15 FSH Receptor Polymorphism p.N680S and Efficacy of FSH Therapy Completed NCT02349945 Phase 2, Phase 3 follitropin alpha
16 Menevit Study: Menevit Anti-Oxidant Therapy for the Treatment of Male Infertility Completed NCT00100269 Phase 3 Menevit anti-oxidant
17 Herbal Tonic Fertile Supplement(ZO2C5) Completed NCT01895816 Phase 3
18 Effect of Letrozole on Seminal Parameters in Men With Non Obstructive Azoospermia and Severe Oligozoospermia. Completed NCT02900105 Phase 3 Letrozole
19 Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma Completed NCT00433459 Phase 3 cyclophosphamide;dacarbazine;prednisolone;prednisone;procarbazine hydrochloride;vincristine sulfate
20 Single Dose Intravesical Apaziquone Postoperative in Patients Undergoing TURBT for Noninvasive Bladder Cancer (SPI-612) Completed NCT00598806 Phase 3 Apaziquone;Placebo
21 The Effect of Combination of Red and White Bahman Retrieved of Iranian Traditional Medicine on Semen Parameters in Idiopathic Oligospermic Men Recruiting NCT02998593 Phase 3 Bahman capsules;Placebo
22 Effect of Walnuts on Sperm Parameters and Male Fertility Recruiting NCT01954498 Phase 2, Phase 3
23 Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia Terminated NCT02605070 Phase 3 Bravelle
24 Aromatase Inhibitors in the Treatment of Male Infertility Terminated NCT00440180 Phase 3 Anastrozole;Placebo
25 Efficacy and Safety of Multi-Instillations of Apaziquone in Patients With Non-Muscle Invasive Bladder Cancer Terminated NCT01410565 Phase 3 Apaziquone;Placebo
26 Androxal in Male Infertility Withdrawn NCT02160704 Phase 2, Phase 3 Enclomiphene citrate
27 Testicular Injection of Autologous Stem Cells for Treatment of Patients With Azoospermia Unknown status NCT02041910 Phase 1, Phase 2
28 The Effect and Safety of Lisinopril in Non-hypertensive Men With Infertility From Low Sperm Count Completed NCT01409837 Phase 2 Lisinopril
29 Denosumab and Male Infertility: a RCT Recruiting NCT03030196 Phase 2 Denosumab
30 Intra-Testicular Transplantation of Autologous Stem Cells for Treatment of Non-Obstructive Azoospermia Male Infertility. Recruiting NCT02641769 Phase 1, Phase 2
31 MSCs For Treatment of Azoospermic Patients Recruiting NCT02025270 Phase 1, Phase 2
32 RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia Recruiting NCT03323801 Phase 2 13-cis retinoic acid
33 GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia Recruiting NCT02544191 Phase 2 GnRHa/ hCG/ hMG
34 Males, Antioxidants, and Infertility Trial Active, not recruiting NCT02421887 Phase 2 Antioxidant Supplement
35 TNFSF11 Inhibition and Fertility: a Prospective Study Active, not recruiting NCT02422108 Phase 2 Denosumab
36 Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration Active, not recruiting NCT01880086 Phase 2 Clomiphene citrate;Placebo
37 RA-2 13-cis Retinoic Acid (Isotretinoin) Active, not recruiting NCT02061384 Phase 2 13-cis retinoic acid;Calcitriol
38 Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility Unknown status NCT02575924 Phase 1 sequential medium;1-step medium
39 A Pilot Study to Evaluate the Effect of Pomegranate Juice on Semen Parameters in Healthy Male Volunteers Completed NCT01595308 Phase 1
40 Choline Dehydrogenase and Sperm Function: Effects of Betaine Completed NCT02122211 Phase 1 Betaine supplement
41 Administration of Clomiphene: Short and Long Term Metabolism in an Anti-Doping Setting Active, not recruiting NCT03028532 Phase 1 Clomid
42 Proposed Research Protocol For Male Infertility Unknown status NCT01255397
43 Oxidative Stress and Lipidomics in Male Infertility Unknown status NCT02062229
44 Is a Carnitine Based Food Supplement (PorimoreTM) for Infertile Men Superior to Folate and Zinc With Regard to Pregnancy Rates in Intrauterine Insemination Cycles? Unknown status NCT01075334
45 Study of Sperm Molecular Factors Implicated in Male Fertility Unknown status NCT00481403
46 Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia Unknown status NCT01178463
47 Management of Peyronie's Disease With Adipose Tissue Stem Cell Unknown status NCT02414308 Adipose tissue stem cell injection
48 Management of Sexual Dysfunction With Bioresonance Technique Unknown status NCT02028013
49 Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia Unknown status NCT02008799
50 Impact of an Antioxidant Alimentary Complement on Sperm Data Unknown status NCT01841034 Conceptio EA

Search NIH Clinical Center for Male Infertility

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: infertility, male

Genetic Tests for Male Infertility

Genetic tests related to Male Infertility:

# Genetic test Affiliating Genes
1 Male Infertility 28

Anatomical Context for Male Infertility

MalaCards organs/tissues related to Male Infertility:

38
Testes, Testis, Liver, Bone, Prostate, Bone Marrow, Pituitary
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Male Infertility:
# Tissue Anatomical CompartmentCell Relevance
1 Testis Seminiferous Tubules Elongated Spermatid Affected by disease
2 Testis Seminiferous Tubules Spermatid Affected by disease
3 Testis Seminiferous Tubules Spermatozoan Affected by disease

Publications for Male Infertility

Articles related to Male Infertility:

(show top 50) (show all 917)
# Title Authors Year
1
Association of the common SNPs in RNF212, STAG3 and RFX2 gene with male infertility with azoospermia in Chinese population. ( 29277047 )
2018
2
Nationwide survey of urological specialists regarding male infertility: results from a 2015 questionnaire in Japan. ( 29371820 )
2018
3
Role of Withania somnifera (Ashwagandha) in the management of male infertility. ( 29277366 )
2018
4
Two cases of reversible male infertility due to congenital adrenal hyperplasia combined with testicular adrenal rest tumor. ( 29371828 )
2018
5
Genetic intersection of male infertility and cancer. ( 29307395 )
2018
6
Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility. ( 29447380 )
2018
7
Mutations in CFAP43 and CFAP44 cause male infertility and flagellum defects in Trypanosoma and human. ( 29449551 )
2018
8
Homozygous missense mutation L673P in adenylate kinase 7 (AK7) leads to primary male infertility and multiple morphological anomalies of the flagella but not to primary ciliary dyskinesia. ( 29365104 )
2018
9
Lack of association between aryl hydrocarbon receptor gene Arg554Lys polymorphism and male infertility risk: A systematic review and meta-analysis. ( 29427904 )
2018
10
Can Tangier disease cause male infertility? A case report and an overview on genetic causes of male infertility and hormonal axis involved. ( 29198592 )
2018
11
Association of asymptomatic Chlamydia trachomatis infection with male infertility and the effect of antibiotic therapy in improvement of semen quality in infected infertile men. ( 29292525 )
2018
12
Human induced pluripotent stem cells and male infertility: an overview of current progress and perspectives. ( 29315416 )
2018
13
Male Infertility Diagnosis and Treatment in the Era of InA Vitro Fertilization and Intracytoplasmic Sperm Injection. ( 29406062 )
2018
14
Male infertility: a biomarker of individual and familial cancer risk. ( 29307404 )
2018
15
The Effect of Omega-3 Fatty Acids, EPA, and/or DHA on Male Infertility: A Systematic Review and Meta-analysis. ( 29451828 )
2018
16
The effects of tomato juice on male infertility. ( 28049263 )
2017
17
Y chromosome microdeletions and varicocele as aetiological factors of male infertility: A cross-sectional study. ( 29265486 )
2017
18
Associations between male infertility and ancestry in South Americans: a case control study. ( 28747152 )
2017
19
eNOS gene T786C, G894T and 4a4b polymorphisms and male infertility susceptibility: a meta-analysis. ( 27373555 )
2017
20
Fluorescence in situ hybridisation sperm examination is significantly impaired in all categories of male infertility. ( 28762516 )
2017
21
Varicocele and male infertility. ( 28675168 )
2017
22
Methylenetetrahydrofolate Reductase C677T Polymorphism and Risk for Male Infertility in Asian Population. ( 28811683 )
2017
23
Genetic variation in leptin and leptin receptor genes as a risk factor for idiopathic male infertility. ( 27813378 )
2017
24
Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility. ( 28797078 )
2017
25
The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis. ( 28050928 )
2017
26
Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis. ( 28397035 )
2017
27
Genetic polymorphisms and haplotypes of the DJ-1 gene promoter associated with the susceptibility to male infertility. ( 28932933 )
2017
28
Effect of Chinese Herbal Medicine on Male Infertility. ( 28807164 )
2017
29
Loss of the Na(+)/H(+) exchanger NHE8 causes male infertility in mice by disrupting acrosome formation. ( 28476888 )
2017
30
Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. ( 28894282 )
2017
31
Office-based andrology and male infertility procedures-a cost-effective alternative. ( 28904909 )
2017
32
Ggnbp2-Null Mutation in Mice Leads to Male Infertility Due to a Defect at the Spermiogenesis Stage. ( 28823874 )
2017
33
TTY2 genes deletions as genetic risk factor of male infertility. ( 28364784 )
2017
34
Ubiquitination-deficient mutations in human Piwi cause male infertility by impairing histone-to-protamine exchange during spermiogenesis. ( 28552346 )
2017
35
In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility. ( 27802063 )
2017
36
Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress. ( 28933362 )
2017
37
Idiopathic male infertility related to periodontal and caries status. ( 28746727 )
2017
38
NR5A1 mutations are not associated with male infertility in Indian men. ( 29265478 )
2017
39
MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis. ( 28081209 )
2017
40
Male infertility - The other side of the equation. ( 28892594 )
2017
41
Correlation between SHBG gene polymorphism and male infertility in Han population of Henan province of China: A STROBE-compliant article. ( 28796064 )
2017
42
Role of Glutathione-S-Transferase Family Genes in Male Infertility. ( 28944422 )
2017
43
Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. ( 27864361 )
2017
44
Male Infertility Associated with a Supernumerary Marker Chromosome. ( 28879694 )
2017
45
Re: Causes of Male Infertility: A 9-Year Prospective Monocentre Study on 1737 Patients with Reduced Total Sperm Counts. ( 28817890 )
2017
46
Association between Methionine Synthase Reductase A66G Polymorphism and Male Infertility: A Meta-Analysis. ( 28436330 )
2017
47
Comparative analysis of testis transcriptomes associated with male infertility in cattleyak. ( 27865410 )
2017
48
Re: Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice. ( 29370627 )
2017
49
Development and implementation of a novel panel consisting 20 markers for the detection of genetic causes of male infertility. ( 29282760 )
2017
50
Glutathione S-transferase P1 Ile105Val Polymorphism and Male Infertility Risk: An Updated Meta-analysis. ( 28397729 )
2017

Variations for Male Infertility

ClinVar genetic disease variations for Male Infertility:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Pathogenic/Likely pathogenic rs200750564 GRCh37 Chromosome 2, 176959246: 176959246

Expression for Male Infertility

Search GEO for disease gene expression data for Male Infertility.

Pathways for Male Infertility

GO Terms for Male Infertility

Cellular components related to Male Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.86 AR BPY2 BPY2B BPY2C DAZ1 DAZ2
2 chromosome GO:0005694 9.56 H2BFWT PRM1 PRM2 TNP2
3 nucleosome GO:0000786 9.33 H2BFWT PRM1 PRM2
4 protein complex GO:0043234 9.17 AR CFTR DAZ1 DAZ2 DAZ3 DAZ4

Biological processes related to Male Infertility according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 single fertilization GO:0007338 9.8 AR BPY2 BPY2B BPY2C DAZ2
2 protein deubiquitination GO:0016579 9.78 AR CFTR USP26 USP9Y
3 germ cell development GO:0007281 9.73 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
4 regulation of translation GO:0006417 9.69 BOLL DAZL PIWIL1
5 positive regulation of translational initiation GO:0045948 9.63 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
6 spermatogenesis GO:0007283 9.53 AR BOLL BPY2 BPY2B BPY2C CATSPER2
7 chromosome condensation GO:0030261 9.49 PRM1 PRM2
8 spermatogenesis, exchange of chromosomal proteins GO:0035093 9.46 PIWIL1 TNP2
9 DNA packaging GO:0006323 9.43 PRM1 PRM2
10 3-UTR-mediated mRNA stabilization GO:0070935 9.43 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
11 multicellular organism development GO:0007275 10.11 BOLL CATSPER2 DAZ1 DAZ2 DAZ3 DAZ4
12 cell differentiation GO:0030154 10.06 BOLL CATSPER2 DAZ1 DAZ2 DAZ3 DAZ4

Molecular functions related to Male Infertility according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA binding GO:0003723 9.92 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
2 mRNA binding GO:0003729 9.7 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
3 HECT domain binding GO:0032399 9.43 BPY2 BPY2B BPY2C
4 mRNA 3-UTR binding GO:0003730 9.43 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
5 translation activator activity GO:0008494 9.1 BOLL DAZ1 DAZ2 DAZ3 DAZ4 DAZL
6 protein binding GO:0005515 10.27 AR BOLL BPY2 BPY2B BPY2C CATSPER2

Sources for Male Infertility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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