MCID: MLN007
MIFTS: 62

Male Infertility malady

Genetic diseases category

Summaries for Male Infertility

About this section
Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. causes of male infertility include physical problems with the testicles blockages in the ducts that carry sperm hormone problems a history of high fevers or mumps genetic disorders lifestyle or environmental factors about a third of the time, infertility is because of a problem with the man. one third of the time, it is a problem with the woman. sometimes no cause can be found. if you suspect you are infertile, see your doctor. there are tests that may tell if you have fertility problems. when it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technologies. happily, two-thirds of couples treated for infertility are able to have babies. nih: national institute of child health and human development

MalaCards: Male Infertility, also known as infertility, male, is related to infertility and azoospermia. An important gene associated with Male Infertility is UBE2B (ubiquitin-conjugating enzyme E2B), and among its related pathways are Viral carcinogenesis and Fertilization. The drugs clomiphene and clomiphene citrate and the compounds pgf and nnc55-0396 have been mentioned in the context of this disorder. Affiliated tissues include testes, testis and prostate, and related mouse phenotype reproductive system.

Wikipedia:63 Male infertility refers to a male\'s inability to achieve a pregnancy in a fertile female. In humans it... more...

Aliases & Classifications for Male Infertility

About this section
Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 33MedlinePlus, 60UMLS, 22GTR, 44Novoseek, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

male infertility 8 46 10 33 60
infertility, male 8 22
male infertility, unspecified 8
male infertility nos 8
infertility male 44


External Ids:

Disease Ontology8 DOID:12336
MeSH34 D007248
ICD9CM27 606.9, 606
ICD1025 Q98.6, Q98.7

Related Diseases for Male Infertility

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Male Infertility family:

Catsper1-Related Nonsyndromic Male Infertility

Diseases related to Male Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1infertility32.1DAZ1, EPPIN, USP26, AZF1
2azoospermia30.8AZF1, USP26, DDX3Y, FKBP6, DAZ1, H2BFWT
3cryptorchidism30.5DAZ1, AZF1
4oligospermia30.4DAZ1
5sertoli cell-only syndrome30.0DAZ1, DDX3Y
6varicocele10.6
7catsper1-related nonsyndromic male infertility10.5
8deafness-infertility syndrome10.4
9prostatitis10.4
10klinefelter's syndrome10.3
11catsper-related male infertility10.3
12spermatogenic failure 410.3
13cystic fibrosis10.3
14congenital adrenal hyperplasia10.3
15obesity10.3
16orchitis10.2
17hypogonadism10.2
18spermatogenic failure 1210.2
1921-hydroxylase deficiency10.1
20adrenal rest tumor10.1
21spermatocele10.1
22polycystic kidney disease10.1
23hydrocephalus10.1
24impotence10.1
25kidney disease10.1
26prostate cancer10.1
27thyroiditis10.1
28spermatogenic failure 510.1
29catsper-related nonsyndromic male infertility10.1
30spermatogenic failure 710.1
31deafness and male infertility10.1
32male infertility due to acrosin deficiency10.1
33urethritis10.0
34teratocarcinoma10.0
35hyperprolactinemia10.0
36hydronephrosis10.0
37prostatic cyst10.0
38mulibrey nanism10.0
39carney complex10.0
40panhypopituitarism10.0
41urethral diverticulum10.0
42primary ciliary dyskinesia10.0
43situs inversus10.0
44morbid obesity10.0
45imperforate anus10.0
46hypogonadotropism10.0
47fibrous dysplasia10.0
48addison's disease10.0
49alopecia10.0
50arthritis10.0

Graphical network of the top 20 diseases related to Male Infertility:



Diseases related to male infertility

Clinical Features for Male Infertility

About this section

Drugs & Therapeutics for Male Infertility

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Male Infertility

Drug clinical trials:

Search ClinicalTrials for Male Infertility

Search NIH Clinical Center for Male Infertility

Search CenterWatch for Male Infertility

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Male Infertility

About this section
Sources:
22GTR
See all sources

Genetic tests related to Male Infertility:

id Genetic test Affiliating Genes
1 Male Infertility22

Anatomical Context for Male Infertility

About this section
Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Male Infertility:

32
Testes, Testis, Prostate, Thyroid, Spinal cord, Kidney, Eye, Ovary, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Male Infertility:
id TissueAnatomical CompartmentCell Relevance
1 TestisSeminiferous TubulesElongated Spermatid Affected by disease
2 TestisSeminiferous TubulesSpermatid Affected by disease
3 TestisSeminiferous TubulesSpermatozoan Affected by disease

Animal Models for Male Infertility or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Male Infertility:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.9OAZ3, FKBP6, TBPL1, UBE2B, AURKC, CATSPER2

Publications for Male Infertility

About this section
Sources:
50PubMed
See all sources

Articles related to Male Infertility:

(show top 50)    (show all 827)
idTitleAuthorsYear
1
Infectious, inflammatory, and immunologic conditions resulting in male infertility. (24286768)
2014
2
Association of interleukin-1beta Ca88+a883953T gene polymorphism with human male infertility. (24067094)
2013
3
Male factor infertility: Standardized diagram improves testicular cell identification. (23938943)
2013
4
Environmentally induced epigenetic transgenerational inheritance of altered Sertoli cell transcriptome and epigenome: molecular etiology of male infertility. (23555832)
2013
5
Cryptorchidism is not a risk factor for antisperm antibody production in post-orchidopexy males with infertility. (23614969)
2013
6
Coenzyme Q10 and male infertility: a meta-analysis. (23912751)
2013
7
Seminal plasma glycoproteins in male infertility and prostate diseases: is there a chance for glyco-biomarkers? (23061682)
2013
8
Association of the Glutathione S-transferases M1 and T1 polymorphism with male infertility: a meta-analysis. (23239128)
2013
9
OGG1 Ser326Cys polymorphism interacts with cigarette smoking to increase oxidative DNA damage in human sperm and the risk of male infertility. (23376476)
2013
10
Evidence for a stimulatory role of high doses of recombinant human follicle-stimulating hormone in the treatment of male-factor infertility. (24215716)
2013
11
Significant association of TNFI+ and IL-6 gene with male infertility--an explorative study in Indian populations of Uttar Pradesh. (24029665)
2013
12
Histopathological patterns of testicular biopsy in male infertility: A retrospective study from a tertiary care center in the western part of Saudi Arabia. (24049394)
2013
13
European Association of Urology guidelines on Male Infertility: the 2012 update. (22591628)
2012
14
Causes and classification of male infertility in Korea. (23346528)
2012
15
Erect posture of humans leads to male infertility, BPH and prostate cancer. (22524496)
2012
16
Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility. (21482674)
2011
17
A single nucleotide polymorphism in a miR-1302 binding site in CGA increases the risk of idiopathic male infertility. (21601192)
2011
18
Relationship between genetic polymorphisms of methylenetetrahydrofolate reductase (C677T, A1298C, and G1793A) as risk factors for idiopathic male infertility. (20978181)
2011
19
Guideline-based management of male infertility: Why do we need it? (21716890)
2011
20
Mast cell tryptase stimulates production of decorin by human testicular peritubular cells: possible role of decorin in male infertility by interfering with growth factor signaling. (21791437)
2011
21
Coenzyme Q(10) in male infertility: physiopathology and therapy. (21989906)
2011
22
Biology of spermatogenesis and male infertility. (20536319)
2010
23
Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1. (21368870)
2010
24
Frequency and severity of sperm DNA damage in patients with confirmed cases of male infertility of different aetiologies. (20378411)
2010
25
Is male infertility a forerunner to cancer? (21044369)
2010
26
Mediterranean fever gene mutation analysis in infertile Turkish males. (20391345)
2010
27
The effect of obesity on sperm disorders and male infertility. (20157305)
2010
28
Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. (19517319)
2009
29
Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility. (18823884)
2009
30
Coenzyme Q10 and male infertility. (19509475)
2009
31
Mitochondrial glutathione peroxidase 4 disruption causes male infertility. (19417079)
2009
32
The role of Chlamydia trachomatis infection in male infertility. (18706556)
2009
33
Mutations of the cyclin A1 gene are not a common cause of male infertility. (19886767)
2009
34
Male infertility related to an aberrant karyotype, 46,XY,9ph,9qh+. (19100539)
2009
35
Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles. (19761617)
2009
36
Analysis of the meiotic recombination gene REC8 for sequence variations in a population with severe male factor infertility. (18570052)
2008
37
Is gene therapy for the treatment of male infertility feasible? (18852706)
2008
38
Addison's disease presenting as male infertility. (16580396)
2006
39
A rapid and simple system of detecting deletions on the Y chromosome related with male infertility using multiplex PCR. (16538008)
2006
40
The common variant N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia. (16257105)
2006
41
CAG repeats of DNA polymerase gamma in Chinese males and relationship of idiopathic male infertility to CAG repeats]. (16970152)
2006
42
The genetic and cytogenetic basis of male infertility. (15823847)
2005
43
Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception. (15659832)
2004
44
Male infertility and avascular necrosis of the femoral head. (15005939)
2004
45
Reversible infertility, pharmaceutical and spontaneous, in a male with late onset congenital adrenal hyperplasia, due to 21-hydroxylase deficiency. (11789681)
2002
46
Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. (11120760)
2000
47
Human chromosome deletions in Yq11, AZF candidate genes and male infertility: history and update. (9733430)
1998
48
Sexual function and clinical features of patients with Klinefelter's syndrome with the chief complaint of male infertility. (9292317)
1997
49
The genetics of male infertility in relation to cystic fibrosis. (9692018)
1997
50
Semen characteristics and diabetes mellitus: significance of insulin in male infertility. (1903630)
1991

Genetic Variations for Male Infertility

About this section

Expression for genes affiliated with Male Infertility

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Male Infertility

Search GEO for disease gene expression data for Male Infertility.

Pathways for genes affiliated with Male Infertility

About this section
Sources:
29KEGG, 53Reactome
See all sources

Pathways related to Male Infertility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7H2BFWT, TBPL1, DDX3Y
2
Hide members
10.6CATSPER2, CATSPER1

Compounds for genes affiliated with Male Infertility

About this section
Sources:
28IUPHAR, 44Novoseek, 11DrugBank
See all sources

Compounds related to Male Infertility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pgf2810.7CATSPER2, CATSPER1
2nnc55-03962810.6CATSPER2, CATSPER1
3mibefradil44 28 1112.6CATSPER2, CATSPER1
4pge12810.5CATSPER1, CATSPER2
5pge22810.3CATSPER2, CATSPER1

GO Terms for genes affiliated with Male Infertility

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CatSper complexGO:03612810.6CATSPER2, CATSPER1

Biological processes related to Male Infertility according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:00728311.2OAZ3, BPY2C, CATSPER1, CATSPER2, UBE2B, FKBP6
2single fertilizationGO:00733810.8CATSPER2, CATSPER1, BPY2C
3cell differentiationGO:03015410.7DAZ3, DAZ1, CATSPER2, CATSPER1
4sperm-egg recognitionGO:03503610.7CATSPER2, CATSPER1
5ciliary or bacterial-type flagellar motilityGO:00153910.7CATSPER1, CATSPER2
6sperm motilityGO:03031710.6CATSPER2, CATSPER1
7multicellular organism reproductionGO:03250410.5CATSPER1, CATSPER2
8multicellular organismal developmentGO:00727510.4DAZ3, DAZ1, CATSPER2, CATSPER1

Molecular functions related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:00372310.7DAZ3, DAZ1, DDX3Y, RBMXL2

Products for genes affiliated with Male Infertility

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Male Infertility

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet