Male Infertility malady

MedlinePlus: Infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. male infertility can result from physical problems, hormone problems, and lifestyle or environmental factors. about a third of the time, infertility is because of a problem with the man. one third of the time, it is a problem with the woman. sometimes no cause can be found. if you suspect you are infertile, see your doctor. there are tests that may tell if you have fertility problems. when it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technologies. happily, two-thirds of couples treated for infertility are able to have babies. dept. of health and human services office on women's health²³

MalaCards: Male Infertility, also known as male infertility nos (finding), is related to y chromosome infertility and deafness and male infertility. An important gene associated with Male Infertility is DEL15Q15.3 (Deafness and male infertility), and among its related pathways are Transcription CREM signaling in testis and Meiotic Recombination. The drugs follitropin beta and follitropin alfa and the compounds dmso and buserelin have been mentioned in the context of this disorder. Affiliated tissues include testis, t cells and b cells, and related mouse phenotypes are nervous system and integument.

Wikipedia: Male infertility refers to the inability of a male to achieve a pregnancy in a fertile female. In humans...⁴⁴ more...

Aliases & Descriptions:

male infertility 6 7 17 8 33 23 43 male infertility nos (finding) 6 male infertility, unspecified 6 male infertility (finding) 6

infertility, male 6 infertility male 32 infertility 43

Diseases related to male infertility by text searches and GeneDecks gene sharing:

(show top 50)    (show all 450)

id	Related Disease	Score	Top Affiliating Genes
1	y chromosome infertility	33.0	RBMY1A1, USP9Y, HSFY1, DDX3Y, DAZ1
2	deafness and male infertility	32.6	CATSPER2, CATSPER2P1, DEL15Q15.3, STRC
3	polycystic ovary syndrome	31.3	LHCGR, CGA, FSHR, AR, GNRH1, CYP19A1
4	cryptorchidism, idiopathic	30.5	AZF1, INSL3, DAZ1, DAZ2, DAZ3, DAZ4
5	sertoli cell-only syndrome	30.2	UTY, USP9Y, AZF1, FSHR, DDX3Y, DAZ1
6	oligospermia	30.1	KLHL10, RBMY1A1, USP9Y, AZF1, CFTR, AR
7	globozoospermia	29.8	PICK1, SPATA16, ACR, CSNK2A2
8	adrenal hyperplasia	29.3	CNC, CGA, AR, FH, GNRH1, CYP19A1
9	azoospermia	29.0	KLHL10, KIT, RBMY1A1, BRCA2, BPY2, BPY2B
10	turner syndrome	28.7	XDH, CGA, CYP21A2, SRY, SHBG, TSPY1
11	cryptorchidism	28.4	USP9Y, CGA, AZF1, KAL1, AR, INSL3
12	virilization	28.2	LHCGR, CGA, AZF1, FSHB, AR, GNRH1
13	21-hydroxylase deficiency	28.2	AR, GNRH1, CYP21A2, SHBG, PRL
14	hypogonadism	28.1	USP26, LHB, LHCGR, CGA, KAL1, FSHB
15	thrombophilia	28.0	MTRR, MTHFR, GSTP1, APOB, CBS, ACE
16	hypogonadotropism	27.7	LHB, LHCGR, CGA, KAL1, FSHB, GNRH1
17	anovulation	27.4	CGA, FSHB, FSHR, GNRH1, CYP19A1, CYP21A2
18	hyperandrogenism	27.3	LHCGR, CGA, FSHR, AR, INSL3, APOB
19	klinefelter's syndrome	26.7	USP9Y, MTHFR, CGA, AZF1, CFTR, KAL1
20	amenorrhea	26.6	LHB, LHCGR, CGA, FSHB, FSHR, AR
21	gonadal dysgenesis	26.5	XDH, AZF1, FSHR, GNRH1, DAZ4, CYP21A2
22	endometritis	26.4	CGA, ESR1, TBPL1, NR5A1, ACE, OXT
23	varicocele	26.3	USP9Y, XDH, CGA, AZF1, GSTM1, GSTT1
24	androgen insensitivity syndrome	26.3	CGA, AR, CYP19A1, SRY, NR5A1, SHBG
25	endometriosis	26.2	KITLG, BRCA2, LHB, MTHFR, XRCC1, XDH
26	fragile x-associated primary ovarian insufficiency	26.1	CGA, FSHR, GNRH1, CYP19A1, SHBG, PRL
27	hemochromatosis	26.1	BRCA2, CFTR, CDAN1, GSTP1, GNRH1, ACE
28	gonadotropin deficiency	26.0	CGA, KAL1, FSHR, GNRH1, CYP19A1, PRL
29	breast cancer	26.0	BRCA2, AR, ESR1, ESR2, CYP1A1, CYP19A1
30	sinusitis	26.0	MTHFR, CGA, CFTR, MIF, GSTP1, CBS
31	infertility	25.9	PICK1, KLHL10, CNC, KIT, KITLG, RBMXL2
32	ovarian hyperstimulation syndrome	25.8	LHCGR, MTHFR, CGA, CFTR, FSHB, FSHR
33	epididymitis	25.8	CFTR, FSHR, AR, GSTP1, GPR64, CAT
34	hereditary leiomyomatosis and renal cell cancer	25.8	FH, GSTM1, GNRH1, ESR1, ESR2, CYP1A1
35	spontaneous abortion	25.6	MTHFR, XDH, CGA, AZF1, AR, GNRH1
36	testicular cancer	25.4	USP9Y, XPC, CGA, AZF1, FSHR, AR
37	hypothyroidism	25.0	CHKA, CGA, FSHR, APOB, GNRH1, CYP21A2
38	breast-ovarian cancer	24.2	KIT, KITLG, BRCA2, MTHFR, XRCC1, AR
39	autoimmune thyroiditis	24.1	CGA, AR, HSPA1B, ESR1, ESR2, CYP21A2
40	huntington's disease	24.0	VDAC1, MTRR, MTHFR, MTR, AR, GNRH1
41	peritonitis	23.6	KIT, KITLG, BRCA2, MTHFR, XDH, CGA
42	cystic fibrosis	23.0	VDAC1, XDH, CFTR, MIF, GSTM1, GSTP1
43	leiomyoma	22.9	KIT, BRCA2, XRCC1, XPA, AR, FH
44	insulin resistance	21.6	LIPE, MTHFR, MTR, CGA, MIF, AR
45	vaginitis	21.5	KIT, CGA, AR, GSTP1, GNRH1, ESR1
46	thyroiditis	21.4	CNC, KIT, KITLG, VDAC1, LHCGR, CHKA
47	fibrosis	21.4	KIT, KITLG, VDAC1, MTHFR, XRCC1, XDH
48	pneumonia	21.3	VDAC1, CHKA, MTHFR, XDH, CFTR, AURKC
49	diabetes mellitus	19.8	VDAC1, LIPE, MTHFR, XRCC1, XDH, CGA
50	homocysteine	19.5	MTRR, MTHFR, MTR, XDH, MIF, GSTM1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 bromocriptine, bromocriptine mesylate, clomiphene, clomiphene citrate, follitropin, follitropin alfa, follitropin beta, leuprolide, leuprolide acetate, sermorelin, sermorelin acetate

MalaCards organs/tissues related to male infertility:

²²

MGI Mouse Phenotypes related to male infertility:

²⁵ (show all 11)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system phenotype	MP:0003631	7.7	NR5A1, SPAG6, CYP19A1, ERCC2, ESR2, CREM
2	integument phenotype	MP:0010771	7.1	AHR, RXFP2, CYP19A1, ERCC1, OXT, OXTR
3	tumorigenesis	MP:0002006	6.1	ESR1, ESR2, ERCC2, ERCC1, RXFP2, ACE
4	behavior/neurological phenotype	MP:0005386	5.8	NR5A1, CYP19A1, ERCC1, ERCC2, ESR2, CBS
5	liver/biliary system phenotype	MP:0005370	5.7	ERCC1, ERCC4, CYP1A1, CYP19A1, CREM, ABCB1
6	growth/size phenotype	MP:0005378	5.6	SPAG6, CYP19A1, ERCC4, ERCC1, ERCC2, ESR2
7	mortality/aging	MP:0010768	5.2	ABCB1, PLA2G6, CREM, NR5A1, PPP1R8, SPAG6
8	homeostasis/metabolism phenotype	MP:0005376	INF	CYP19A1, CYP1A1, ERCC1, ERCC2, ESR2, ESR1
9	reproductive system phenotype	MP:0005389	INF	OXTR, KCNU1, GAPDHS, PRM3, PRL, PRM2
10	cellular phenotype	MP:0005384	INF	CREM, NR5A1, CYP19A1, DDX4, TBPL1, ERCC4
11	endocrine/exocrine gland phenotype	MP:0005379	INF	PICK1, KLHL10, SERPINA5, SEPT12, BRCA2, BOLL

Articles related to male infertility:

(show top 50)    (show all 227)

id	Title	Authors	Year	Affiliating Genes
1	Male infertility-linked point mutation disrupts the C a2+ oscillation-inducing and PIP(2) hydrolysis activity of sperm PLCIP. (21204786)	Nomikos M.... Lai F.A.	2011	PLCZ1
2	Human sperm physiology: estrogen receptor alpha (ERI+) and estrogen receptor beta (ERI^) influence sperm metabolism and may be involve d in the pathophysiology of varicocele-associated male infertility. (21344398)	Guido C.... Aquila S.	2011	ESR1, ESR2
3	Glutathione-S-transferase gene polymorphisms (GSTM1, GSTT1, GSTP1) and idiopathic male infertility: novel perspectives versus facts. (20686491)	Economopoulos K.P.... Choussein S.	2010	GSTT1, GSTM1
4	Male infertility associated with hereditary leiomyoma tosis and renal cell carcinoma. (20056206)	McKelvey K.D.... Batres F.	2010	FH
5	Association of polymorphisms in the estrogen receptor s alpha, and beta (ESR1, ESR2) with the occurrence of male infertility and seme n parameters. (20599614)	Safarinejad M.R.... Safarinejad S.	2010	ESR1, ESR2
6	Spermatozoal protein profiles in male infertility with asthenozoospermia. (21034600)	Li H.J.... Li H.Z.	2010	DDX4
7	Variants of the EPPIN gene affect the risk of idiopat hic male infertility in the Han-Chinese population. (20488803)	Ding X.... Wang X.	2010	EPPIN
8	The association of glutathione-S-transferase gene pol ymorphisms (GSTM1, GSTT1, GSTP1) with idiopathic male infertility. (20505681)	Safarinejad M.R.... Safarinejad S.	2010	GSTP1, GSTT1, GSTM1
9	Association of the MDR1 (ABCB1) gene 3435C>T polym orphism with male infertility. (19815951)	DroA_dzik M.... Kurzawski M.	2009	ABCB1
10	Single nucleotide polymorphism analysis of the follic le-stimulating hormone (FSH) receptor in Japanese with male infertility: identi fication of codon combination with heterozygous variations of the two discrete FSH receptor gene. (19550076)	Shimoda C.... Namiki M.	2009	FSHR
11	PICK1 deficiency causes male infertility in mice by disrupting acrosome formation. (19258705)	Xiao N.... Xia J.	2009	PICK1
12	Genetics and male infertility (20088251)	Stouffs K.... Lissens W.	2009	MSH4, STRA8, AZF1
13	Treatment of male infertility secondary to morbid obe sity. (18523426)	Roth M.Y.... Page S.T.	2008	CYP19A1
14	Molecular analysis of Y chromosome microdeletions in idiopathic cases of male infertility in Serbia. (17853812)	Ristanovic M.... Nikolic A.	2007	AZF1
15	Imbalance in seminal fluid MIF indicates male infertility. (17592555)	Aljabari B.... Al-Abed Y.	2007	MIF
16	TSPY gene copy number as a potential new risk factor for male infertility. (17509197)	Vodicka R.... Santavy J.	2007	TSPY1
17	Premature translation of transition protein 2 mRNA causes sperm abnormalities and male infertility. (16967499)	Tseden K.... Nayernia K.	2007	TNP2
18	Lack of Spem1 causes aberrant cytoplasm removal, sperm deformation, and male infertility. (17426145)	Zheng H.... Yan W.	2007	SPEM1
19	Treatment of male infertility. (18225678)	Check J.H.	2007	CGA
20	Involvement of ALF in human spermatogenesis and male infertility. (16525715)	Huang M.... Sha J.	2006	GTF2A1L
21	Identification of polymorphisms and balancing selection in the male infertility candidate gene, ornithine decarboxylase antizyme 3. (16542438)	Christensen G.L.... Carrell D.T.	2006	OAZ3
22	The role of the testis-specific gene hTAF7L in the aetiology of male infertility. (16597641)	Stouffs K.... Liebaers I.	2006	TAF7L
23	The common variant N372H in BRCA2 gene may be associated with idiopathic male infertility with azoospermia or severe oligozoospermia. (16257105)	Zhoucun A.... Lin L.	2006	BRCA2
24	Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (16989827)	Aoki V.W.... Carrell D.T.	2006	TNP1, PRM1, TNP2
25	Genotyping of congenital adrenal hyperplasia due to 21-hydroxylase deficiency presenting as male infertility: case report and literature review. (17033937)	Sugino Y.... Nishiyama H.	2006	CYP21A2
26	Multilocus analyses of estrogen-related genes reveal involvement of the ESR1 gene in male infertility and the polygenic nature of the pathology. (16213843)	Galan J.J.... Ruiz A.	2005	ESR1, ESR2, FSHR
27	Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility. (16123080)	Yang X.J.... Nakahori Y.	2005	DAZL, DAZ1
28	Alternatively spliced protein variants as potential therapeutic targets for male infertility and contraception. (15659832)	Fardilha M.... da Cruz e Silva E.F.	2004	PPP1CC, NEK2, PPP1R8
29	CFTR mutations and polymorphisms in male infertility. (15379964)	Cuppens H.... Cassiman J.J.	2004	CFTR
30	Androgen receptor and male infertility (15524101)	Eldar-Geva T.... Halle D.	2004	AR
31	High risk genetic factor in Chinese patients with idiopathic male infertility: deletion of DAZ gene copy on Y chromosome. (15265388)	Yang Y.... Lin L.	2004	DAZ1
32	Molecular characterization of heat shock-like factor encoded on the human Y chromosome, and implications for male infertility. (15044259)	Shinka T.... Nakahori Y.	2004	HSFX1, HSFY1, HSFY2
33	The present and future state of hormonal treatment fo r male infertility. (12638778)	Liu P.Y.... Handelsman D.J.	2003	CYP19A1
34	Androgen receptor gene and male infertility. (12638777)	Yong E.L.... Sim K.S.	2003	AR
35	Genetic variations of gpx-4 and male infertility in humans. (12606444)	Maiorino M.... Flohe L.	2003	GPX4
36	Searching for candidate genes for male infertility. (12778326)	Truong B.N.... Baker H.W.	2003	CSNK2A2
37	Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1. (11994405)	Firestein R.... Cleary M.L.	2002	SBF1
38	Re: Aromatase inhibitors for male infertility. (12352445)	Terris M.K.... McCallum S.W.	2002	CYP19A1
39	Genetic markers of male infertility: Y chromosome microdeletions and cystic fibrosis transmembrane conductance gene mutations. (11471192)	SertiA8 J.... StavljeniA8 Rukavina A.	2001	CFTR
40	Identification of human candidate genes for male infertility by digital differential display. (11134355)	Olesen C.... Tommerup N.	2001	FATE1
41	Microdeletion of chromosome Y in male infertility: role of the DAZ gene (11688365)	Foresta C.... Scandellari C.	2001	DAZ1, DAZ2, DAZ3
42	Decreased expression of the heat shock protein hsp70-2 is associated with the pathogenesis of male infertility. (11730740)	Feng H.L.... Sparks A.E.	2001	HSPA1B
43	Mutations at the mitochondrial DNA polymerase (POLG) locus associated with male infertility. (11687794)	Rovio A.T.... Jacobs H.T.	2001	POLG, POLG2
44	Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. (11120760)	Uhrin P.... Geiger M.	2000	SERPINA5
45	The critical region of overlap defining the AZFa male infertility interval of proximal Yq contains three transcribed sequences. (10507722)	Sargent C.A.... Affara N.A.	1999	USP9Y, DDX3Y, TTTY15
46	Severe male infertility. Genetic investigation and c ounseling prior to intracytoplasmic sperm injection (10235038)	Mikkelsen L.	1999	CFTR
47	An exon map of the AZFc male infertility region of th e human Y chromosome. (9892735)	Wong J.... Affara N.A.	1999	USP9Y
48	Analysis of the transactivation domain of the androgen receptor in patients with male infertility. (9788719)	Wang Q.... Yong E.L.	1998	AR
49	Effect of reactive oxygen species and the activity of antioxidant systems on human semen; association with male infertility. (16130269)	Sanocka D.... Kurpisz M.	1997	SOD1, CAT, XDH
50	A study on intratesticular aromatase activity in male infertility (7776564)	Ichikawa T.	1995	CYP19A1

Genes related to male infertility according to GeneCards:

(show top 50)    (show all 172)

id	Symbol	Description	Score	GeneCards Section Context
1	DEL15Q15.3	Deafness and male infertility	11.1	Aliases & Descriptions
2	BPY2B	basic charge, Y-linked, 2B	11.1	Publications, Summaries
3	BPY2C	basic charge, Y-linked, 2C	11.1	Publications, Summaries
4	BPY2	basic charge, Y-linked, 2	11.1	Summaries, Publications
5	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked	11.1	Orthologs, Summaries, Publications
6	USP26	ubiquitin specific peptidase 26	11.1	Publications, Summaries
7	OAZ3	ornithine decarboxylase antizyme 3	11.1	Summaries, Publications
8	RBMXL2	RNA binding motif protein, X-linked-like 2	11.1	Summaries
9	H2BFWT	H2B histone family, member W, testis-specific	11.1	Publications, Summaries
10	TBPL1	TBP-like 1	11.1	Publications, Summaries
11	AURKC	aurora kinase C	11.0	Publications
12	EPPIN	epididymal peptidase inhibitor	11.0	Summaries, Publications
13	CATSPER2P1	cation channel, sperm associated 2 pseudogene 1	11.0	Publications
14	STRC	stereocilin	11.0	Publications
15	CATSPER2	cation channel, sperm associated 2	11.0	Publications
16	CATSPER1	cation channel, sperm associated 1	11.0	Publications, Disorders
17	ACR	acrosin	11.0	Publications
18	PPIP5K1P1	diphosphoinositol pentakisphosphate kinase 1 pseudogene 1	11.0	Publications
19	STRCP1	stereocilin pseudogene 1	11.0	Publications
20	AZF1	azoospermia factor 1	11.0	Publications
21	PRM3	protamine 3	11.0	Publications
22	TTTY15	testis-specific transcript, Y-linked 15 (non-protein coding)	11.0	Publications
23	DAZ3	deleted in azoospermia 3	11.0	Publications
24	DAZ1	deleted in azoospermia 1	11.0	Publications
25	DAZ2	deleted in azoospermia 2	11.0	Publications
26	PRM1	protamine 1	11.0	Publications
27	HSFX2	heat shock transcription factor family, X linked 2	11.0	Publications
28	DAZ4	deleted in azoospermia 4	11.0	Publications
29	USP9Y	ubiquitin specific peptidase 9, Y-linked	11.0	Publications
30	HSFY2	heat shock transcription factor, Y linked 2	11.0	Publications
31	SPEM1	spermatid maturation 1	11.0	Publications
32	TNP2	transition protein 2 (during histone to protamine replacement)	11.0	Publications
33	HSFY1	heat shock transcription factor, Y-linked 1	11.0	Publications
34	HSFX1	heat shock transcription factor family, X linked 1	11.0	Publications
35	PRM2	protamine 2	11.0	Publications
36	SMCP	sperm mitochondria-associated cysteine-rich protein	11.0	Publications, Functions
37	IGFL3	IGF-like family member 3	11.0	Publications
38	DAZL	deleted in azoospermia-like	11.0	Publications
39	GTF2A1L	general transcription factor IIA, 1-like	11.0	Publications
40	TNP1	transition protein 1 (during histone to protamine replacement)	11.0	Publications
41	FATE1	fetal and adult testis expressed 1	11.0	Publications
42	KLHL10	kelch-like 10 (Drosophila)	11.0	Publications
43	SEPT12	septin 12	11.0	Publications
44	CNC	Carney complex, multiple neoplasia and lentiginosis	11.0	Publications
45	FKBPL	FK506 binding protein like	11.0	Publications
46	TEKT2	tektin 2 (testicular)	11.0	Publications
47	IZUMO1	izumo sperm-egg fusion 1	11.0	Publications
48	TSSK2	testis-specific serine kinase 2	11.0	Publications
49	TSPY1	testis specific protein, Y-linked 1	11.0	Publications
50	STRA8	stimulated by retinoic acid gene 8 homolog (mouse)	11.0	Publications

Pathways related to male infertility according to GeneDecks:

(show all 14)

id	Pathway	Score	Top Affiliating Genes
1	Transcription CREM signaling in testis10	10.6	TSSK2, CREM, TNP1, FSHR, FSHB
2	Meiotic Recombination38	10.4	SPO11, MLH3, MSH5, MSH4, BRCA2
3	Dual incision reaction in GG-NER38	10.4	XPA, XPC, ERCC1, ERCC4
4	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics34	10.1	CBS, MTR, MTHFR, MTRR
5	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	9.9	CBS, GSTM1, MTR, MTHFR, MTRR
6	Transcription_CREM signaling in testis41	9.9	FSHB, FSHR, TNP1, CREM, ACE, TSSK2
7	DNA Repair Mechanisms36	9.8	POLG, ERCC4, ERCC1, ERCC2, XPC, XPA
8	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	9.7	SLC19A1, ABCB1, CBS, MTR, MTHFR, MTRR
9	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)41	9.6	SOD1, HSPA8, HSPA1B, HSPA2, CFTR
10	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	9.5	SOD1, GSTT1, GSTP1, GSTM1
11	Doxorubicin Pathway (Cancer Cell), Pharmacodynamics34	9.3	SOD1, ABCB1, ERCC2, CAT, XDH
12	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics34	9.3	ESR2, ESR1, CYP19A1
13	Development Role of Activin A in cell differentiation and proliferation10	INF	NR5A1, , LHCGR, CGA, FSHB, FSHR
14	Development_Role of Activin A in cell differentiation and proliferation41	INF	NR5A1, FSHR, FSHB, CGA, LHCGR,

Compounds related to male infertility according to GeneDecks:

(show top 50)    (show all 201)

id	Compound	Score	Top Affiliating Genes
1	dmso32	9.3	OXTR, GPX4, XDH, KITLG, CGA, AHR
2	buserelin32 9 9	11.3	GNRH1, CYP19A1, OXT, PRL, LHCGR, FSHB
3	toremifene32 9 9	11.2	CYP1A1, PRL, CYP19A1, ESR2, ABCB1
4	dehydroepiandrosterone sulfate32	9.2	AR, PRL, GNRH1, CYP21A2, NR5A1, SHBG
5	aspartate32	9.1	GNRH1, OXT, CSNK2A2, SHBG, CYP19A1, DUSP19
6	oxaliplatin32 34 9 9	12.1	GSTT1, GSTM1, MTHFR, XRCC1, XPA, GSTP1
7	naringenin32 9 9	11.0	CYP1A1, CYP19A1, APOB, ESR1, AHR, ESR2
8	benzo(a)pyrene32	8.9	XRCC1, AHR, XPA, XPC, GSTM1, GSTP1
9	gsts32	8.8	GSTM1, MTHFR, XRCC1, MIF, GSTP1, GSTT1
10	betacarotene32	8.8	MTHFR, CHKA, PON1, GSTM1, APOB, CAT
11	leuprolide acetate32	8.7	SHBG, CYP21A2, PRL, LHCGR, CGA, FSHB
12	clomiphene citrate32	8.7	ESR2, PRL, SHBG, CYP21A2, ESR1, GNRH1
13	progestin32	8.6	OXT, PRL, OXTR, CGA, AR, GNRH1
14	diethylstilbestrol32 9 9	10.6	CYP19A1, NR5A1, SHBG, ABCB1, ESR1, CGA
15	estradiol benzoate32	8.6	OXT, PLA2G6, CYP19A1, ESR2, GNRH1, CGA
16	cysteine32	8.5	MTHFR, MTR, VDAC1, SRY, CASP14, XDH
17	flutamide32 9 9	10.5	AHR, SHBG, CYP19A1, ESR1, GNRH1, AR
18	ascorbic acid32 18	9.5	GSTP1, CGA, CFTR, CHKA, GSTM1, GSTT1
19	dopamine32 9 18 9	11.4	CSNK2A2, CFTR, OXTR, OXT, PLA2G6, DUSP19
20	thymidylate32	8.4	GSTM1, CFTR, XRCC1, MTR, MTHFR, MTRR
21	h2o232	8.4	GPX4, XDH, CGA, PON1, CSNK2A2, OXT
22	epinephrine32 9 18 9	11.3	TF, KITLG, SHBG, LIPE, CGA, CFTR
23	androstenedione32 18	9.3	GNRH1, ESR2, CYP19A1, CYP21A2, SHBG, PRL
24	glutamate32	8.2	CHKA, PLA2G6, MTR, STYX, AHR, OXT
25	valine32	8.2	CSNK2A2, OXT, CYP21A2, CYP1A1, HSPA8, MTHFR
26	folate32	8.2	GSTT1, SLC19A2, GSTP1, GSTM1, CGA, XRCC1
27	alanine32	8.1	SRY, PTMA, RXFP2, SHBG, AHR, TF
28	alpha tocopherol32	8.1	CAT, DUSP19, TF, SOD1, PON1, HSPA8
29	adenylate32	7.9	POLG, HSPA8, ESR2, DUSP19, DAZL, NR5A1
30	quercetin32 42 9 18 9	11.8	CAT, CFTR, AR, GSTP1, HSPA8, ESR2
31	estrone32 9 18 9	10.6	PRL, CYP19A1, AR, CYP1A1, AHR, ABCB1
32	dihydrotestosterone32 9 18 9	10.6	GNRH1, PRL, ABCB1, SHBG, SRY, CYP21A2
33	progesterone32 42 9 18 9	11.6	NR5A1, CYP21A2, OXT, ESR2, PRL, OXTR
34	5fluorouracil32	7.6	XRCC1, GSTM1, GSTP1, GNRH1, ESR1, ERCC2
35	mifepristone32 42 9 9	10.5	AR, PRL, OXTR, OXT, SHBG, CYP19A1
36	actinomycin d32	7.2	ABCB1, PLA2G6, KIT, NR5A1, CYP1A1, KITLG
37	cisplatin32 34 9 9	10.2	ERCC2, VDAC1, BCL2L2, DUSP19, SLC19A1, KITLG
38	genistein32 9 18 9	10.0	DUSP19, CYP1A1, ESR2, ESR1, APOB, ABCB1
39	estradiol32 9 18 9	9.9	KITLG, BRCA2, LHCGR, CHKA, CGA, FSHB
40	doxorubicin32 34 9 9	9.8	ESR2, CFTR, CGA, AR, ESR1, MIF
41	methotrexate32 34 42 9 9	10.8	ABCB1, ERCC1, ERCC2, ESR1, CBS, GSTP1
42	tamoxifen32 34 9 9	9.7	AHR, AR, ABCB1, TF, BRCA2, CHKA
43	serine32	6.5	MTR, APOB, CGA, CFTR, FSHR, MTRR
44	lactate32	6.5	CAT, CYP1A1, SHBG, ACR, OXT, SOD1
45	steroid32	6.4	KIT, SRY, NR5A1, NRIP1, SHBG, AHR
46	arginine32	6.3	PRL, OXTR, SOD1, CSNK2A2, PON1, SLC19A1
47	testosterone32 9 18 9	9.1	KIT, KITLG, BRCA2, LHCGR, CHKA, MTHFR
48	creatinine32	5.4	GSTP1, GSTM1, FH, MIF, CGA, MTR
49	estrogen32	3.9	PON1, CSNK2A2, KIT, KITLG, BRCA2, LIPE
50	gnrh32	INF	KAL1, FSHB, FSHR, AR, CYP21A2, NR5A1

Cellular components related to male infertility according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	male germ cell nucleus	GO:001673	10.4	MLH3, TNP1, ACTL7A, SYCP1
2	nucleosome	GO:000786	10.4	PRM1, PRM2, PRM3, H2BFWT, H2BFS, TNP2
3	protein complex	GO:043234	9.8	PPP1CC, ACR, ACTL7A, SOD1, NEK2, HMGB2
4	cytoplasm	GO:005737	8.0	PPIP5K1, SPAG6, SPEM1, SRY, DAZL, DAZ4
5	nucleus	GO:005634	7.0	POLL, PPIP5K1, SPO11, OAZ3, SRY, DAZL

Biological processes related to male infertility according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	multicellular organismal development	GO:007275	10.8	SPATA16, SPATA9, SPEM1, CREM, PLCZ1, TSSK2
2	sperm motility	GO:030317	10.7	GAPDHS, SMCP, DDX4, TEKT2, TNP2, TNP1
3	cell differentiation	GO:030154	10.7	SPATA9, SPEM1, NR5A1, CREM, TSPY1, TAF7L
4	positive regulation of translational initiation	GO:045948	10.6	DAZL, DAZ1, DDX3X, BOLL
5	penetration of zona pellucida	GO:007341	10.6	TNP2, SMCP, ACR
6	spermatid nucleus differentiation	GO:007289	10.6	TBPL1, TNP1, HMGB2
7	spermatid development	GO:007286	10.4	GAPDHS, PRM1, TSSK2, SPAG6, TNP1, HSPA2
8	nucleotide-excision repair, DNA damage removal	GO:000718	10.2	ERCC4, ERCC1, ERCC2, XPC, XPA
9	female gamete generation	GO:007292	10.2	MSH4, FSHB, FSHR, SPO11
10	reciprocal meiotic recombination	GO:007131	10.1	STRA8, SYCP1, SPO11, MLH3
11	UV protection	GO:009650	10.0	ERCC4, ERCC1, ERCC2, CAT
12	nucleotide-excision repair	GO:006289	10.0	POLL, ERCC4, ERCC1, ERCC2, XPC, XPA
13	spermatogenesis	GO:007283	9.7	SLC26A8, SPATA9, SPATA16, OAZ3, DAZL, DAZ4
14	ovarian follicle development	GO:001541	9.7	SOD1, STRA8, AHR, ESR2, FSHB, MSH4
15	small molecule metabolic process	GO:044281	INF	CAT, CYP1A1, CYP19A1, CYP21A2, OAZ3, PPP1CC
16	male gonad development	GO:008584	INF	HMGB2, ERCC1, CYP19A1, NR5A1, RXFP2, MAS1

Molecular functions related to male infertility according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide hormone binding	GO:017046	10.3	OXTR, RXFP2, MAS1, FSHR, LHCGR
2	damaged DNA binding	GO:003684	10.1	ERCC4, ERCC1, HMGB2, XPC, XPA, XRCC1
3	protease binding	GO:002020	10.0	POLG, HSPA1B, INSL3, BRCA2, SERPINA5, KIT
4	single-stranded DNA binding	GO:003697	9.9	POLG2, ERCC4, ERCC1, HMGB2, XPC, BRCA2
5	DNA binding	GO:003677	9.6	NR5A1, CREM, ACR, H2BFS, H2BFWT, AHR
6	ATP binding	GO:005524	8.6	ERCC2, DDX3X, DDX3Y, DDX4, SPO11, PPIP5K1
7	protein binding	GO:005515	4.3	GAPDHS, CREM, NRIP1, NR5A1, PPP1R8, PPP1CC