MCID: MLN007
MIFTS: 54

Male Infertility malady

Reproductive diseases category
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Summaries for Male Infertility

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MedlinePlus:33 Infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. causes of male infertility include physical problems with the testicles blockages in the ducts that carry sperm hormone problems a history of high fevers or mumps genetic disorders lifestyle or environmental factors about a third of the time, infertility is because of a problem with the man. one third of the time, it is a problem with the woman. sometimes no cause can be found. if you suspect you are infertile, see your doctor. there are tests that may tell if you have fertility problems. when it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technologies. happily, two-thirds of couples treated for infertility are able to have babies. nih: national institute of child health and human development

MalaCards based summary: Male Infertility, also known as infertility male, is related to infertility and oligospermia. An important gene associated with Male Infertility is UBE2B (ubiquitin-conjugating enzyme E2B), and among its related pathways is Reproduction. The drugs clomiphene and clomiphene citrate and the compounds nnc55-0396 and pgf1alpha have been mentioned in the context of this disorder. Affiliated tissues include testes, testis and prostate.

Wikipedia:65 Male infertility refers to a male\'s inability to cause pregnancy in a fertile female. In humans it... more...

Aliases & Classifications for Male Infertility

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Male Infertility, Aliases & Descriptions:

Name: Male Infertility 30 8 22 46 10 33 62
 
Infertility Male 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


External Ids:

Disease Ontology8 DOID:12336
ICD9CM27 606.9, 606
MeSH34 D007248

Related Diseases for Male Infertility

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Diseases related to Male Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1infertility32.0EPPIN, USP26, AZF1
2oligospermia30.5DDX3Y, AZF1
3sertoli cell-only syndrome30.5DDX3Y
4azoospermia30.2DDX3Y, AZF1, USP26, H2BFWT, FKBP6
5varicocele10.6
6catsper1-related nonsyndromic male infertility10.6
7deafness-infertility syndrome10.5
8prostatitis10.5
9cryptorchidism10.4
10cystic fibrosis10.4
11globozoospermia10.4
12klinefelter's syndrome10.4
13catsper-related male infertility10.4
14spermatogenic failure 410.4
15obesity10.3
16congenital adrenal hyperplasia10.3
17deafness and male infertility10.3
18orchitis10.3
19hypogonadism10.3
20spermatogenic failure 810.3
21catsper-related nonsyndromic male infertility10.3
22spermatogenic failure 710.3
23male infertility due to nanos1 mutation10.3
24y chromosome infertility10.2DDX3Y
2521-hydroxylase deficiency10.2
26hydrocephalus10.2
27prostate cancer10.2
28spinal cord injury10.2
29adrenal rest tumor10.2
30polycystic kidney disease10.2
31spermatocele10.2
32impotence10.2
33kidney disease10.2
34thyroiditis10.2
35spermatogenic failure 510.2
36testicular microlithiasis10.2
37male infertility due to acrosin deficiency10.2
38epididymitis10.2
39vesiculitis10.2
40alopecia10.0
41arthritis10.0
42avascular necrosis of the femoral head10.0
43cataract10.0
44diabetes mellitus10.0
45morbid obesity10.0
46primary ciliary dyskinesia10.0
47renal cell carcinoma10.0
48sinusitis10.0
49hypogonadotropism10.0
50situs inversus10.0

Graphical network of the top 20 diseases related to Male Infertility:



Diseases related to male infertility

Symptoms for Male Infertility

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Drugs & Therapeutics for Male Infertility

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Drug clinical trials:

Search ClinicalTrials for Male Infertility

Search NIH Clinical Center for Male Infertility

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Male Infertility

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Genetic tests related to Male Infertility:

id Genetic test Affiliating Genes
1 Male Infertility22

Anatomical Context for Male Infertility

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MalaCards organs/tissues related to Male Infertility:

32
Testes, Testis, Prostate, Spinal cord, Kidney, Thyroid, Eye, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Male Infertility:
id TissueAnatomical CompartmentCell Relevance
1 TestisSeminiferous TubulesElongated Spermatid Affected by disease
2 TestisSeminiferous TubulesSpermatid Affected by disease
3 TestisSeminiferous TubulesSpermatozoan Affected by disease

Animal Models for Male Infertility or affiliated genes

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Publications for Male Infertility

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Articles related to Male Infertility:

(show top 50)    (show all 714)
idTitleAuthorsYear
1
The field of male infertility moves fast! (24286780)
2014
2
Empirical medical therapy in idiopathic male infertility: Promise or panacea? (25309854)
2014
3
Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. (23512232)
2013
4
GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects. (23877133)
2013
5
Association of GSTM1 and GSTT1 genes with the susceptibility to male infertility: result from a meta-analysis. (23631429)
2013
6
The use of genomics, proteomics, and metabolomics in identifying biomarkers of male infertility. (23415969)
2013
7
Reproductive outcomes in patients with male infertility because of Klinefelter's syndrome, Kartagener's syndrome, round-head sperm, dysplasia fibrous sheath, and 'stump' tail sperm: an updated literature review. (23587797)
2013
8
No CAG repeat expansion of polymerase gamma is associated with male infertility in Tamil Nadu, South India. (24339545)
2013
9
Association of the gonadotrophin-regulated testicular RNA helicase gene polymorphism with human male infertility. (24168058)
2013
10
The utility and cost of Chlamydia trachomatis and Neisseria gonorrhoeae screening of a male infertility population. (22192351)
2012
11
Association between the JC polyomavirus infection and male infertility. (22912758)
2012
12
Focus issue on male infertility. (22190920)
2012
13
Higher proportion of haploid round spermatids and spermatogenic disomy rate in relation to idiopathic male infertility. (21094989)
2011
14
Antioxidant therapy in male infertility: fact or fiction? (21516118)
2011
15
Testicular failure and male infertility in the monogenic Mulibrey nanism disorder. (21865362)
2011
16
Evaluating the role of the FSH receptor gene Thr307-Ala and Asn680-Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones. (21105990)
2011
17
Male infertility: pathogenesis and clinical diagnosis. (21397198)
2011
18
Assessment of the level of trace element zinc in seminal plasma of males and evaluation of its role in male infertility. (23776785)
2011
19
Human male infertility associated with mutations in NR5A1 encoding steroidogenic factor 1. (20887963)
2010
20
Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility: a comparative study. (20845296)
2010
21
Study on the relationship between partial deletions in the azzospermia factor C region of Y chromosome and male infertility]. (20533269)
2010
22
Biology of spermatogenesis and male infertility. (20536319)
2010
23
Association of male infertility with (CAG)n polymorphism of the androgen receptor gene: a meta-analysis]. (19947564)
2009
24
Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. (19517319)
2009
25
Mitochondrial DNA mutations and male infertility. (21088712)
2009
26
Increased sperm chromatin decondensation in selected nonapoptotic spermatozoa of patients with male infertility. (18823884)
2009
27
Male infertility associated with adult dominant polycystic kidney disease: a case series. (19137444)
2009
28
Hormonal treatment of male infertility: promises and pitfalls. (18930905)
2009
29
Use of the aromatase inhibitor letrozole to treat male infertility. (19524225)
2009
30
The orphan nuclear receptor small heterodimer partner mediates male infertility induced by diethylstilbestrol in mice. (19884658)
2009
31
Male infertility in the era of ART: why treat; how to treat. (19247911)
2009
32
Association of the MDR1 (ABCB1) gene 3435C>T polymorphism with male infertility. (19815951)
2009
33
Antioxidant therapy in male infertility. (18423251)
2008
34
Families of two: meeting the needs of couples experiencing male infertility. (18715377)
2008
35
Trials of antioxidants for male infertility. (18275588)
2008
36
Autosomal DAZL single nucleotide polymorphisms not associated with male infertility in northeast China]. (17918711)
2007
37
Association between the apolipoprotein B signal peptide gene insertion/deletion polymorphism and male infertility. (17071710)
2006
38
Male infertility: no evidence of involvement of androgen receptor gene among Indian men. (16400085)
2006
39
Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development. (16923965)
2006
40
Molecular evaluation of CFTR sequence variants in male infertility of testicular origin. (16128988)
2005
41
Molecular pathology of the CFTR locus in male infertility. (15705292)
2005
42
Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. (15340058)
2004
43
Idiopathic cases of male infertility from a region in India show low incidence of Y-chromosome microdeletion. (14517364)
2003
44
Specific expression of VCY2 in human male germ cells and its involvement in the pathogenesis of male infertility. (12724276)
2003
45
CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations. (12399527)
2002
46
The cystic fibrosis transmembrane regulator gene and male infertility. (11097434)
2000
47
Y chromosome and male infertility]. (9644848)
1998
48
Long polyglutamine tracts in the androgen receptor are associated with reduced trans-activation, impaired sperm production, and male infertility. (9360540)
1997
49
A study on intratesticular aromatase activity in male infertility]. (7776564)
1995
50
Chronic prostato-vesiculitis and sperm-cell mobility in male infertility. (696189)
1978

Variations for Male Infertility

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Expression for genes affiliated with Male Infertility

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Expression patterns in normal tissues for genes affiliated with Male Infertility

Search GEO for disease gene expression data for Male Infertility.

Pathways for genes affiliated with Male Infertility

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Pathways related to Male Infertility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8CATSPER1, CATSPER2

Compounds for genes affiliated with Male Infertility

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank
See all sources

Compounds related to Male Infertility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1nnc55-0396289.8CATSPER2, CATSPER1
2pgf1alpha289.8CATSPER2, CATSPER1
3mibefradil44 28 1111.8CATSPER2, CATSPER1
4pge1289.7CATSPER1, CATSPER2
5pge2289.5CATSPER2, CATSPER1

GO Terms for genes affiliated with Male Infertility

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Cellular components related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CatSper complexGO:0361289.8CATSPER1, CATSPER2

Biological processes related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1multicellular organism reproductionGO:0325049.8CATSPER1, CATSPER2
2sperm-egg recognitionGO:0350369.5CATSPER1, CATSPER2
3single fertilizationGO:0073389.0BPY2C, CATSPER2, CATSPER1
4spermatogenesisGO:0072838.6UBE2B, CATSPER1, CATSPER2, BPY2C, FKBP6

Products for genes affiliated with Male Infertility

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Sources for Male Infertility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet