MCID: MLN007
MIFTS: 62

Male Infertility malady

Genetic diseases category

Summaries for Male Infertility

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Sources:
33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. causes of male infertility include physical problems with the testicles blockages in the ducts that carry sperm hormone problems a history of high fevers or mumps genetic disorders lifestyle or environmental factors about a third of the time, infertility is because of a problem with the man. one third of the time, it is a problem with the woman. sometimes no cause can be found. if you suspect you are infertile, see your doctor. there are tests that may tell if you have fertility problems. when it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technologies. happily, two-thirds of couples treated for infertility are able to have babies. nih: national institute of child health and human development

MalaCards: Male Infertility, also known as infertility, male, is related to infertility and azoospermia. An important gene associated with Male Infertility is UBE2B (ubiquitin-conjugating enzyme E2B), and among its related pathways are Viral carcinogenesis and Fertilization. The drugs clomiphene and clomiphene citrate and the compounds pgf and nnc55-0396 have been mentioned in the context of this disorder. Affiliated tissues include testes, testis and prostate, and related mouse phenotype reproductive system.

Wikipedia:63 Male infertility refers to a male\'s inability to achieve a pregnancy in a fertile female. In humans it... more...

Aliases & Classifications for Male Infertility

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Sources:
8Disease Ontology, 46OMIM, 10DISEASES, 33MedlinePlus, 60UMLS, 22GTR, 44Novoseek, 34MeSH, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases


Aliases & Descriptions:

male infertility 8 46 10 33 60
infertility, male 8 22
male infertility, unspecified 8
male infertility nos 8
infertility male 44


External Ids:

Disease Ontology8 DOID:12336
MeSH34 D007248
ICD9CM27 606.9, 606
ICD1025 Q98.6, Q98.7

Related Diseases for Male Infertility

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Male Infertility family:

Catsper1-Related Nonsyndromic Male Infertility

Diseases related to Male Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1infertility32.1DAZ1, EPPIN, USP26, AZF1
2azoospermia30.8AZF1, USP26, DDX3Y, FKBP6, DAZ1, H2BFWT
3cryptorchidism30.5DAZ1, AZF1
4oligospermia30.4DAZ1
5sertoli cell-only syndrome30.0DAZ1, DDX3Y
6varicocele10.6
7catsper1-related nonsyndromic male infertility10.5
8deafness-infertility syndrome10.4
9prostatitis10.4
10klinefelter's syndrome10.3
11catsper-related male infertility10.3
12spermatogenic failure 410.3
13cystic fibrosis10.3
14congenital adrenal hyperplasia10.3
15obesity10.3
16orchitis10.2
17hypogonadism10.2
18spermatogenic failure 1210.2
1921-hydroxylase deficiency10.1
20adrenal rest tumor10.1
21spermatocele10.1
22polycystic kidney disease10.1
23hydrocephalus10.1
24impotence10.1
25kidney disease10.1
26prostate cancer10.1
27thyroiditis10.1
28spermatogenic failure 510.1
29catsper-related nonsyndromic male infertility10.1
30spermatogenic failure 710.1
31deafness and male infertility10.1
32male infertility due to acrosin deficiency10.1
33urethritis10.0
34teratocarcinoma10.0
35hyperprolactinemia10.0
36hydronephrosis10.0
37prostatic cyst10.0
38mulibrey nanism10.0
39carney complex10.0
40panhypopituitarism10.0
41urethral diverticulum10.0
42primary ciliary dyskinesia10.0
43situs inversus10.0
44morbid obesity10.0
45imperforate anus10.0
46hypogonadotropism10.0
47fibrous dysplasia10.0
48addison's disease10.0
49alopecia10.0
50arthritis10.0

Graphical network of the top 20 diseases related to Male Infertility:



Diseases related to male infertility

Clinical Features for Male Infertility

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Drugs & Therapeutics for Male Infertility

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Male Infertility

Drug clinical trials:

Search ClinicalTrials for Male Infertility

Search NIH Clinical Center for Male Infertility

Search CenterWatch for Male Infertility

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Male Infertility

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Sources:
22GTR
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Genetic tests related to Male Infertility:

id Genetic test Affiliating Genes
1 Male Infertility22

Anatomical Context for Male Infertility

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Male Infertility:

32
Testes, Testis, Prostate, Thyroid, Spinal cord, Kidney, Eye, Ovary, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Male Infertility:
id TissueAnatomical CompartmentCell Relevance
1 TestisSeminiferous TubulesElongated Spermatid Affected by disease
2 TestisSeminiferous TubulesSpermatid Affected by disease
3 TestisSeminiferous TubulesSpermatozoan Affected by disease

Animal Models for Male Infertility or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Male Infertility:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538910.9OAZ3, FKBP6, TBPL1, UBE2B, AURKC, CATSPER2

Publications for Male Infertility

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Sources:
50PubMed
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Articles related to Male Infertility:

(show top 50)    (show all 827)
idTitleAuthorsYear
1
Genetic variants in telomerase reverse transcriptase (TERT) and telomerase-associated protein 1 (TEP1) and the risk of male infertility. (24269974)
2014
2
Associations of variants in MTHFR and MTRR genes with male infertility in the Jordanian population. (24334125)
2014
3
IL-18 levels in the semen of male infertility: Semen analysis. (24333229)
2013
4
Male infertility: assessment of juvenile testicular dysfunction and risk for malignancy in cryptorchid boys based on resin section evaluation. (24047353)
2013
5
Smoking status modifies the relation between CYP1A1*2C gene polymorphism and idiopathic male infertility: the importance of gene-environment interaction analysis for genetic studies of the disease. (23548414)
2013
6
Clinical relevance of Y-linked CNV screening in male infertility: new insights based on the 8-year experience of a diagnostic genetic laboratory. (24193344)
2013
7
Polymorphisms in aryl hydrocarbon receptor gene are associated with idiopathic male factor infertility. (23703535)
2013
8
Involvement of sperm plasma membrane and cytoskeletal proteins in human male infertility. (23174138)
2013
9
Self-Reported Infertility Among Male and Female Veterans Serving During Operation Enduring Freedom/Operation Iraqi Freedom. (24261648)
2013
10
Global human tissue profiling and protein network analysis reveals distinct levels of transcriptional germline-specificity and identifies target genes for male infertility. (22926843)
2012
11
The role of hypothyroidism in male infertility and erectile dysfunction. (22395839)
2012
12
Re: varicocele and male factor infertility treatment: a new meta-analysis and review of the role of varicocele repair. (22237364)
2012
13
Male infertility after endoscopic Totally Extraperitoneal (Tep) hernia repair (Main): rationale and design of a prospective observational cohort study. (22612995)
2012
14
The effect of the new 2010 World Health Organization criteria for semen analyses on male infertility. (22921910)
2012
15
The effect of mahogunin gene mutant on reproduction in male mice: a new sight for infertility? (23210986)
2012
16
Analysis of seminal plasma from patients with non-obstructive azoospermia and identification of candidate biomarkers of male infertility. (22188163)
2012
17
Common variants in mismatch repair genes associated with increased risk of sperm DNA damage and male infertility. (22594646)
2012
18
An association study of SPO11 gene single nucleotide polymorphisms with idiopathic male infertility in Chinese Han population. (21556891)
2011
19
Structural variation of the human genome: mechanisms, assays, and role in male infertility. (21210740)
2011
20
Prevalent false positives of azoospermia factor a (AZFa) microdeletions caused by single-nucleotide polymorphism rs72609647 in the sY84 screening of male infertility. (21765443)
2011
21
Re: Eggert-Kruse et al.: Are chlamydial lipopolysaccharide-directed antibodies in seminal plasma or serum clinically significant during investigation of male infertility? (Urology 2011;77:1101-1106). (21884923)
2011
22
Current studies on bacterospermia the leading cause of male infertility: a protAcgAc and potential threat towards mans extinction. (22363079)
2011
23
Clinical significance of sperm DNA damage threshold value in the assessment of male infertility. (21960513)
2011
24
Genetic and epigenetic factors: Role in male infertility. (21716934)
2011
25
Angiotensin (1-7) and its receptor Mas are expressed in the human testis: implications for male infertility. (20361351)
2010
26
Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial. (19268928)
2010
27
Male infertility joins the translational medicine revolution. Sperm DNA: from basic science to clinical reality. (19942679)
2010
28
Workplace exposures and male infertility - a case-control study. (21306978)
2010
29
Role of glutathione S-transferase Mu-1 (GSTM1) polymorphism in oligospermic infertile males. (20629642)
2010
30
Male infertility in the era of ART: why treat; how to treat. (19247911)
2009
31
Screening of 'Y' chromosome microdeletions in Iranian infertile males. (19562056)
2008
32
Y chromosome microdeletions in infertile male candidates for microfertilization]. (18720745)
2008
33
The Y chromosome and male infertility. (18832950)
2008
34
Treatment of male infertility. (18225678)
2007
35
Male infertility and varicocele: myths and reality. (19582201)
2007
36
Cigarette smoking and the risk of male infertility. (19090244)
2007
37
Male infertility: no evidence of involvement of androgen receptor gene among Indian men. (16400085)
2006
38
Identification of novel polymorphisms in the nuclear protein genes and their relationship with human sperm protamine deficiency and severe male infertility. (16989827)
2006
39
Androgen receptor CAG polymorphism (Xq11-12) status and human spermatogenesis: a prospective analysis of infertile males and their offspring conceived by intracytoplasmic sperm injection. (16865224)
2006
40
The role of the testis-specific gene hTAF7L in the aetiology of male infertility. (16597641)
2006
41
Y chromosome and male infertility: update, 2006. (16720375)
2006
42
Association of male infertility with Pro185Ala polymorphism in the aryl hydrocarbon receptor repressor gene: implication for the susceptibility to dioxins. (15474075)
2004
43
Stem cell based therapeutical approach of male infertility by teratocarcinoma derived germ cells. (15163638)
2004
44
The methylenetethrahydrofolate reductase (MTHFR) C677T polymorphism and male infertility in Italy. (14594111)
2003
45
Elevated steroidogenesis, defective reproductive organs, and infertility in transgenic male mice overexpressing human chorionic gonadotropin. (12960071)
2003
46
Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele. (11870126)
2002
47
Relationship between expansion of the CAG repeat in exon 1 of the androgen receptor gene and idiopathic male infertility. (11591412)
2001
48
Y chromosome and male infertility]. (9644848)
1998
49
A putative human male infertility gene DAZLA: genomic structure and methylation status. (9294855)
1997
50
Reversible male infertility in late onset congenital adrenal hyperplasia. (1649214)
1991

Genetic Variations for Male Infertility

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Expression for genes affiliated with Male Infertility

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Male Infertility

Search GEO for disease gene expression data for Male Infertility.

Pathways for genes affiliated with Male Infertility

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29KEGG, 53Reactome
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Pathways related to Male Infertility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7H2BFWT, TBPL1, DDX3Y
2
Hide members
10.6CATSPER2, CATSPER1

Compounds for genes affiliated with Male Infertility

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Sources:
28IUPHAR, 44Novoseek, 11DrugBank
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Compounds related to Male Infertility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1pgf2810.7CATSPER2, CATSPER1
2nnc55-03962810.6CATSPER2, CATSPER1
3mibefradil44 28 1112.6CATSPER2, CATSPER1
4pge12810.5CATSPER1, CATSPER2
5pge22810.3CATSPER2, CATSPER1

GO Terms for genes affiliated with Male Infertility

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16Gene Ontology
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Cellular components related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1CatSper complexGO:03612810.6CATSPER2, CATSPER1

Biological processes related to Male Infertility according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1spermatogenesisGO:00728311.2OAZ3, BPY2C, CATSPER1, CATSPER2, UBE2B, FKBP6
2single fertilizationGO:00733810.8CATSPER2, CATSPER1, BPY2C
3cell differentiationGO:03015410.7DAZ3, DAZ1, CATSPER2, CATSPER1
4sperm-egg recognitionGO:03503610.7CATSPER2, CATSPER1
5ciliary or bacterial-type flagellar motilityGO:00153910.7CATSPER1, CATSPER2
6sperm motilityGO:03031710.6CATSPER2, CATSPER1
7multicellular organism reproductionGO:03250410.5CATSPER1, CATSPER2
8multicellular organismal developmentGO:00727510.4DAZ3, DAZ1, CATSPER2, CATSPER1

Molecular functions related to Male Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:00372310.7DAZ3, DAZ1, DDX3Y, RBMXL2

Products for genes affiliated with Male Infertility

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Sources for Male Infertility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet