Aliases & Classifications for Male Infertility

Aliases & Descriptions for Male Infertility:

Name: Male Infertility 38 12 29 41 14 69
Infertility, Male 42
Infertility Male 52

Classifications:



External Ids:

Disease Ontology 12 DOID:12336
ICD10 33 N46 N46.9
ICD9CM 35 606 606.9
MeSH 42 D007248
UMLS 69 C0021364

Summaries for Male Infertility

MedlinePlus : 41 infertility is a term doctors use if a man hasn't been able to get a woman pregnant after at least one year of trying. causes of male infertility include physical problems with the testicles blockages in the ducts that carry sperm hormone problems a history of high fevers or mumps genetic disorders lifestyle or environmental factors about a third of the time, infertility is because of a problem with the man. one third of the time, it is a problem with the woman. sometimes no cause can be found. if you suspect you are infertile, see your doctor. there are tests that may tell if you have fertility problems. when it is possible to find the cause, treatments may include medicines, surgery, or assisted reproductive technology. happily, many couples treated for infertility are able to have babies. nih: national institute of child health and human development

MalaCards based summary : Male Infertility, also known as infertility, male, is related to catsper1-related nonsyndromic male infertility and catsper-related male infertility, and has symptoms including subfertility, male, inability to conceive due to male infertility and inability to impregnate. An important gene associated with Male Infertility is USP26 (Ubiquitin Specific Peptidase 26). The drugs Dexamethasone and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include Testis and Testis, and related phenotype is Increased shRNA abundance (Z-score > 2).

Wikipedia : 71 Male infertility refers to a male\'s inability to cause pregnancy in a fertile female. In humans it... more...

Related Diseases for Male Infertility

Diseases related to Male Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
id Related Disease Score Top Affiliating Genes
1 catsper1-related nonsyndromic male infertility 12.3
2 catsper-related male infertility 12.2
3 non-syndromic male infertility due to sperm motility disorder 12.2
4 rare idiopathic male infertility 12.1
5 male infertility with spermatogenesis disorder due to single gene mutation 12.0
6 male infertility with teratozoospermia due to single gene mutation 12.0
7 male infertility with spermatogenesis disorder 12.0
8 spermatogenic failure 6 11.8
9 deafness-infertility syndrome 11.7
10 spermatogenic failure 5 11.6
11 macrozoospermia 11.5
12 azoospermia 11.3
13 spermatogenic failure 7 11.1
14 oligospermia 11.1
15 infertility 11.0
16 spermatogenic failure 17 11.0
17 spermatogenic failure, x-linked, 2 11.0
18 young syndrome 10.9
19 spermatogenic failure 9 10.7
20 spermatogenic failure 10 10.7
21 sertoli cell-only syndrome 10.7
22 spermatogenic failure 14 10.7
23 ciliary dyskinesia, primary, 22 10.7
24 spermatogenic failure 13 10.7
25 spermatogenic failure, y-linked, 1 10.7
26 primary ciliary dyskinesia 34 10.7
27 glucocorticoid resistance 10.7
28 spermatogenic failure, y-linked, 2 10.7
29 ciliary dyskinesia, primary, 18 10.7
30 19p13.12 microdeletion syndrome 10.2 DAZ1 DAZL DDX3Y USP9Y
31 retinitis pigmentosa, y-linked 10.2 DAZ1 DAZ4 USP9Y
32 transient neonatal thrombocytopenia 10.2 PRM1 PRM2
33 varicocele 10.1
34 gastrointestinal tularemia 10.1 AR CFTR DAZ1 DAZ4
35 silicosis 10.1 DAZ1 DDX3Y USP26 USP9Y
36 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.1 AR DAZ1 DAZ4
37 prostatitis 10.0
38 cryptorchidism 10.0
39 nephronophthisis-like nephropathy 1 10.0 DAZ1 DAZL RBMY1A1 USP9Y
40 pauciarticular onset juvenile idiopathic arthritis 9.9 DAZ1 DAZ4 DDX3Y RBMY1A1 USP9Y
41 klinefelter's syndrome 9.9
42 cystic fibrosis 9.9
43 chlamydia 9.9
44 obesity 9.8
45 congenital adrenal hyperplasia 9.8
46 hypogonadism 9.8
47 thyroiditis 9.8
48 inguinal hernia 9.8
49 orchitis 9.8
50 hydrocephalus 9.7

Graphical network of the top 20 diseases related to Male Infertility:



Diseases related to Male Infertility

Symptoms & Phenotypes for Male Infertility

UMLS symptoms related to Male Infertility:


subfertility, male, inability to conceive due to male infertility, inability to impregnate

GenomeRNAi Phenotypes related to Male Infertility according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.98 BPY2C BPY2B EPPIN BPY2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.98 BPY2B BPY2C EPPIN BPY2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.98 EPPIN
4 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.98 EPPIN
5 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.98 EPPIN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-196 9.98 BPY2B BPY2C BPY2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.98 BPY2C BPY2 BPY2B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.98 EPPIN
9 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.98 EPPIN
10 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.98 BPY2C BPY2B BPY2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.98 BPY2C BPY2 BPY2B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.98 EPPIN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.98 EPPIN
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-109 9.83 EPPIN
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.83 BPY2 BPY2B BPY2C
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.83 EPPIN
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.83 BPY2 BPY2B BPY2C EPPIN
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.83 EPPIN
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.83 EPPIN
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.83 BPY2 BPY2B BPY2C
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.83 EPPIN

Drugs & Therapeutics for Male Infertility

Drugs for Male Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 526)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Early Phase 1 50-02-2 5743
2
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
3
Testosterone Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 58-22-0 6013
4
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757 53477783
5
Tamoxifen Approved Phase 4,Phase 3 10540-29-1 2733526
6
Metformin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 657-24-9 14219 4091
7
Goserelin Approved Phase 4,Phase 3,Phase 2 65807-02-5 47725 5311128
8
Buserelin Approved Phase 4,Phase 3 57982-77-1
9
Selenium Approved, Vet_approved Phase 4,Phase 2 7782-49-2
10
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Early Phase 1 137-58-6 3676
11
Leuprolide Approved, Investigational Phase 4,Phase 3 53714-56-0 3911 657181
12
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 112809-51-5 3902
13
Cetrorelix Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 120287-85-6 16129715 25074887
14
Ganirelix Approved Phase 4,Phase 3,Phase 2 123246-29-7, 124904-93-4 25081094
15
Lenograstim Approved Phase 4,Phase 3,Phase 2,Phase 1 135968-09-1
16
Menthol Approved Phase 4,Phase 3,Early Phase 1 2216-51-5 16666
17
Methyltestosterone Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 58-18-4 6010
18
Menotropins Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 61489-71-2 5360545
19
Ethanol Approved Phase 4,Phase 2 64-17-5 702
20
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6 772 46507594
21
Dopamine Approved Phase 4,Phase 2,Phase 3 51-61-6, 62-31-7 681
22
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-43-4 5816
23
Acetaminophen Approved Phase 4,Phase 2,Phase 3 103-90-2 1983
24
Estrone Approved Phase 4,Early Phase 1 53-16-7 5870
25
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1 9004-61-9 53477741 24759
26
Pentoxifylline Approved, Investigational Phase 4,Phase 3 6493-05-6 4740
27
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
28
Desogestrel Approved Phase 4 54024-22-5 40973
29
Levonorgestrel Approved, Investigational Phase 4 797-63-7, 17489-40-6 13109
30
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
31
Danazol Approved Phase 4 17230-88-5 28417
32
Bupivacaine Approved, Investigational Phase 4,Phase 1 2180-92-9, 38396-39-3 2474
33
Nafarelin Approved Phase 4 76932-56-4 16129618 25077649
34
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
35
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
36
Cefixime Approved Phase 4 79350-37-1 54362 5362065
37
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
39
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
40
Ethinyl Estradiol Approved Phase 4,Phase 1 57-63-6 5991
41
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3 71-58-9
42
Dalteparin Approved Phase 4,Phase 2,Phase 3,Phase 1 9041-08-1
43
Levobupivacaine Approved Phase 4 27262-47-1 92253
44
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
45
Norepinephrine Approved Phase 4 51-41-2 439260
46
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
47
Ticlopidine Approved Phase 4 55142-85-3 5472
48
Nandrolone decanoate Approved, Illicit Phase 4 360-70-3 9677
49
Nandrolone Approved, Experimental, Illicit Phase 4 434-22-0, 62-90-8 9904 229455
50 Dienogest Approved Phase 4 65928-58-7

Interventional clinical trials:

(show top 50) (show all 1420)
id Name Status NCT ID Phase
1 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
2 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4
3 Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH Unknown status NCT02307994 Phase 4
4 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4
5 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
6 Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation Unknown status NCT00417183 Phase 4
7 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4
8 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4
9 Corifollitropin Alfa Versus Follitropin Beta in High Responders Unknown status NCT02471677 Phase 4
10 Type of Gonadotropin and Embryo Kinetics of Development Unknown status NCT02402192 Phase 4
11 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial. Unknown status NCT01992731 Phase 4
12 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
13 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4
14 Intrauterine Insemination and Luteal Fase Support Unknown status NCT01826747 Phase 4
15 Study of Dual Trigger Ovulation in Oocyte Donors Unknown status NCT01443546 Phase 4
16 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4
17 Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs Unknown status NCT00415792 Phase 4
18 The Effect of LH-Priming During Early Follicular Phase in IVF Treatment. Unknown status NCT00334425 Phase 4
19 Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF Unknown status NCT02070198 Phase 4
20 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
21 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4
22 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4
23 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
24 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
25 Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study Completed NCT02204826 Phase 4
26 Effects of Korean Red Ginseng on Male Infertility Completed NCT02202382 Phase 4
27 Severe LH Suppressed Patients After Administration of a GnRH Antagonist Completed NCT01936077 Phase 4
28 Comparison of Outcomes of Two Approaches in Microsurgical Varicocelectomy in Chinese Infertile Males: A Prospective Randomized, Controlled Trial Completed NCT01463787 Phase 4
29 Effect of Treatment With Myo-inositol on Human Semen Parameters in Patients Undergoing In Vitro Fertilization Cycles Completed NCT01560065 Phase 4
30 Sexual Absorption of Vaginal Progesterone Completed NCT01959464 Phase 4
31 Ovarian Stimulation and Intrauterine Insemination in Women With Polycystic Ovarian Syndrome Completed NCT01675843 Phase 4
32 Observational Study of Male Circumcision Using PrePex Device Completed NCT01711411 Phase 4
33 The Role of Massage in Increasing Total Motile Sperm Count of IUI Completed NCT01969825 Phase 4
34 A Prospective Field Study: Introducing the Shang Ring in Routine Clinical Settings Completed NCT01567436 Phase 4
35 Safety and Acceptability of the PrePex™ Device for Male Circumcision in Zambia Completed NCT01844102 Phase 4
36 Role of Laparoscopy in Unexplained Infertility Completed NCT00886041 Phase 4
37 The Effect of LMWH on ICSI in Patients With Unexplained Infertility and Negative Immunological Markers Completed NCT02861105 Phase 4
38 Endometrial Shedding Prior to Ovulation Induction Pilot Study Completed NCT02340013 Phase 4
39 Efficacy and Safety of R-hLH (Luveris ®) Priming Prior to R-HFSH Treatment in Infertile Women Undergoing IVF-ET Completed NCT00441324 Phase 4
40 Multicenter, Randomized, Open Label, Parallel Study to Evaluate the Efficacy & Safety of IVF-M HP Inj. vs. Menopur® Inj. Completed NCT02458768 Phase 4
41 Luteal Phase FSH in the IVF Poor Responder Completed NCT00225433 Phase 4
42 Dosage Optimization for Letrozole Treatment Completed NCT01315912 Phase 4
43 Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development Completed NCT00993902 Phase 4
44 Low Dose hCG in the Late Follicular Phase Completed NCT00750100 Phase 4
45 Programming by Estrogen Treatment in Gonadotropin Releasing Hormone Antagonist Protocol Completed NCT01419353 Phase 4
46 Endometrial Markers and Response of Endometriosis Patients to Prolonged GnRH Agonist Prior to IVF Completed NCT00621179 Phase 4
47 Efficacy of Embryo Transfer Procedure Guided by Transvaginal Ultrasound Versus Abdominal Ultrasound in Oocytes Recipients Completed NCT01137461 Phase 4
48 Tolerability and Satisfaction With Evie Completed NCT01969812 Phase 4
49 MENOPUR® Versus FOLLISTIM® Completed NCT00802360 Phase 4
50 Perifollicular Vascularity Assessment in in-Vitro Fertilization Completed NCT00458380 Phase 4

Search NIH Clinical Center for Male Infertility

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: infertility, male

Genetic Tests for Male Infertility

Genetic tests related to Male Infertility:

id Genetic test Affiliating Genes
1 Male Infertility 29

Anatomical Context for Male Infertility

MalaCards organs/tissues related to Male Infertility:

39
Testes, Testis, Prostate, Thyroid, Endothelial, Kidney, Spinal Cord
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Male Infertility:
id Tissue Anatomical CompartmentCell Relevance
1 Testis Seminiferous Tubules Elongated Spermatid Affected by disease
2 Testis Seminiferous Tubules Spermatid Affected by disease
3 Testis Seminiferous Tubules Spermatozoan Affected by disease

Publications for Male Infertility

Articles related to Male Infertility:

(show top 50) (show all 865)
id Title Authors Year
1
In silico analysis of candidate proteins sharing homology with Streptococcus agalactiae proteins and their role in male infertility. ( 27802063 )
2017
2
The SPO11-C631T gene polymorphism and male infertility risk: a meta-analysis. ( 28050928 )
2017
3
Comparative analysis of testis transcriptomes associated with male infertility in cattleyak. ( 27865410 )
2017
4
The effects of tomato juice on male infertility. ( 28049263 )
2017
5
Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts. ( 27864361 )
2017
6
MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis. ( 28081209 )
2017
7
TTY2 genes deletions as genetic risk factor of male infertility. ( 28364784 )
2017
8
Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites. ( 26970590 )
2016
9
Association of the methylenetetrahydrofolate reductase gene C677T polymorphism with the risk of male infertility: a meta-analysis. ( 26584688 )
2016
10
Evaluation of serum level of Osteocalcin hormone in male infertility. ( 28000970 )
2016
11
CAG-repeat polymorphisms in the polymerase I^ gene and male infertility: a meta-analysis. ( 26790834 )
2016
12
Ureaplasma urealyticum in male genital tract: a hidden risk factor for male infertility. ( 27897333 )
2016
13
Methionine synthase A2756G transition might be a risk factor for male infertility: Evidences from seven case-control studies. ( 26905524 )
2016
14
Re: The "Omics" of Human Male Infertility: Integrating Big Data in a Systems Biology Approach. ( 27628827 )
2016
15
Association between C677T and A1298C polymorphisms of the MTHFR gene and risk of male infertility: a meta-analysis. ( 27173242 )
2016
16
The polymorphism G4C14-to-A4T14 in p73 gene may affect the susceptibility to male infertility with severe spermatogenesis impairment in Chinese population. ( 27525684 )
2016
17
Oxidative stress and the etiology of male infertility. ( 27544275 )
2016
18
Current medical management of endocrine-related male infertility. ( 27072045 )
2016
19
Genetics of Male Infertility. ( 27502429 )
2016
20
Low-level environmental arsenic exposure correlates with unexplained male infertility risk. ( 27485131 )
2016
21
Large Scale 7436-bp Deletions in Human Sperm Mitochondrial DNA with Spermatozoa Dysfunction and Male Infertility. ( 28050401 )
2016
22
Asymptomatic Infection With Mycoplasma hominis Negatively Affects Semen Parameters and Leads to Male Infertility as Confirmed by Improved Semen Parameters After Antibiotic Treatment. ( 27871827 )
2016
23
Sterile inflammation as a factor in human male infertility: Involvement of Toll like receptor 2, biglycan and peritubular cells. ( 27849015 )
2016
24
Sperm mitochondrial DNA 15bp deletion of cytochrome c oxidase subunit III is significantly associated with human male infertility in Pakistan. ( 26712170 )
2016
25
Association of C677T transition of the human methylenetetrahydrofolate reductase (MTHFR) gene with male infertility. ( 25412139 )
2016
26
Mutations in DNAJB13, Encoding an HSP40 Family Member, Cause Primary Ciliary Dyskinesia and Male Infertility. ( 27486783 )
2016
27
Treatment of Leukocytospermia in Male Infertility: A Systematic Review. ( 28053945 )
2016
28
Male infertility following inguinal hernia repair: a systematic review and pooled analysis. ( 27915384 )
2016
29
Re: Introduction: Ejaculatory Problems and Male Infertility. ( 27191102 )
2016
30
New insights for male infertility revealed by alterations in spermatic function and differential testicular expression of thyroid-related genes. ( 27066791 )
2016
31
Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility. ( 27973917 )
2016
32
Protective Effect of Decursin Extracted from Angelica gigas in Male Infertility via Nrf2/HO-1 Signaling Pathway. ( 27034737 )
2016
33
Male infertility: an obstacle to sexuality? ( 27061770 )
2016
34
Immune mediators associated to male infertility in a mouse model of DNA immunization with the sperm protease proacrosin. ( 27606569 )
2016
35
Association of polymorphisms of A260G and A386G in DAZL gene with male infertility: a meta-analysis and systemic review. ( 25994644 )
2016
36
Stem cells, gene therapy, and advanced medical management hold promise in the treatment of male infertility. ( 27056350 )
2016
37
The effect of a specific histidine-rich glycoprotein polymorphism on male infertility and semen parameters. ( 27210772 )
2016
38
The role of carnitine in male infertility. ( 27152678 )
2016
39
Influence radio and chemotherapy cancer patients to development of male infertility (literature review). ( 28027542 )
2016
40
Male infertility in mice lacking the store-operated Ca(2+) channel Orai1. ( 26969191 )
2016
41
Seminal biomarkers for the evaluation of male infertility. ( 26975492 )
2016
42
To Evaluate the Efficacy of Combination Antioxidant Therapy on Oxidative Stress Parameters in Seminal Plasma in the Male Infertility. ( 27630911 )
2016
43
gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population. ( 27457284 )
2016
44
Common SNP in hsa-miR-196a-2 increases hsa-miR-196a-5p expression and predisposes to idiopathic male infertility in Chinese Han population. ( 26805933 )
2016
45
Initiative for standardization of reporting genetics of male infertility. ( 27870555 )
2016
46
Association between methylenetetrahydrofolate reductase (MTHFR) gene promoter hypermethylation and the risk of idiopathic male infertility. ( 27596009 )
2016
47
Low levels of PRSS37 protein in sperm are associated with many cases of unexplained male infertility. ( 27649891 )
2016
48
Genetic factors contributing to human primary ciliary dyskinesia and male infertility. ( 27270341 )
2016
49
Current medical management of endocrine-related male infertility. ( 27098657 )
2016
50
Testosterone and Male Infertility. ( 27132576 )
2016

Variations for Male Infertility

ClinVar genetic disease variations for Male Infertility:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 HOXD13 NM_000523.3(HOXD13): c.820C> T (p.Arg274Ter) single nucleotide variant Pathogenic/Likely pathogenic rs200750564 GRCh37 Chromosome 2, 176959246: 176959246

Expression for Male Infertility

Search GEO for disease gene expression data for Male Infertility.

Pathways for Male Infertility

GO Terms for Male Infertility

Cellular components related to Male Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.47 AR BPY2 BPY2B BPY2C DAZ1 DAZ4
2 chromosome GO:0005694 9.46 H2BFWT PRM1 PRM2 TNP2
3 nucleosome GO:0000786 9.13 H2BFWT PRM1 PRM2

Biological processes related to Male Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.92 BOLL CATSPER2 DAZ1 DAZ4 DAZL PRM1
2 protein deubiquitination GO:0016579 9.71 AR CFTR USP26 USP9Y
3 single fertilization GO:0007338 9.56 AR BPY2 BPY2B BPY2C
4 cell differentiation GO:0030154 9.56 BOLL CATSPER2 DAZ1 DAZ4 DAZL PRM1
5 spermatogenesis GO:0007283 9.44 AR BOLL BPY2 BPY2B BPY2C CATSPER2
6 chromosome condensation GO:0030261 9.43 PRM1 PRM2
7 DNA packaging GO:0006323 9.37 PRM1 PRM2
8 positive regulation of translational initiation GO:0045948 9.33 BOLL DAZ1 DAZL

Molecular functions related to Male Infertility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleic acid binding GO:0003676 9.63 BOLL DAZ1 DAZ4 DAZL DDX3Y RBMY1A1
2 translation activator activity GO:0008494 9.13 BOLL DAZ1 DAZL
3 HECT domain binding GO:0032399 8.8 BPY2 BPY2B BPY2C

Sources for Male Infertility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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