MCID: MLR006
MIFTS: 34

Male Reproductive Organ Cancer

Categories: Cancer diseases

Aliases & Classifications for Male Reproductive Organ Cancer

MalaCards integrated aliases for Male Reproductive Organ Cancer:

Name: Male Reproductive Organ Cancer 12 14
Genital Neoplasms, Male 41 69
Malignant Neoplasm of Male Genital Organ, Site Unspecified 12
Malignant Neoplasm of Male Genital Organ, Unspecified 12
Malignant Neoplasm of Male Genital Organ or Tract 12
Malignant Neoplasm of Male Genital Organ, Nos 12
Malignant Tumor of Male Reproductive System 12
Malignant Neoplasm of Male Genital Organs 12
Malignant Tumor of Male Genital Organ 12
Male Reproductive System Neoplasm 12
Tumor of Male Reproductive System 12
Neoplasm of Male Genital Organ 12
Male Genital Neoplasm 12
Male Genital Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3856
ICD9CM 34 187.9
MeSH 41 D005834
NCIt 46 C3054 C8561

Summaries for Male Reproductive Organ Cancer

Disease Ontology : 12 A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.

MalaCards based summary : Male Reproductive Organ Cancer, also known as genital neoplasms, male, is related to prostate cancer and seminal vesicle adenocarcinoma. An important gene associated with Male Reproductive Organ Cancer is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Related phenotypes are endocrine/exocrine gland and adipose tissue

Related Diseases for Male Reproductive Organ Cancer

Diseases related to Male Reproductive Organ Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 prostate cancer 30.7 AKT1 AMACR AR CYP17A1 FOLH1 GRP
2 seminal vesicle adenocarcinoma 11.0
3 littre gland carcinoma 11.0
4 cowper gland carcinoma 11.0
5 urethral diverticulum 10.6 AMACR KLK3 NKX3-1
6 prostatic acinar adenocarcinoma 10.6 AMACR AR KLK3 TMPRSS2
7 clear cell adenocarcinoma 10.6 AMACR KLK3 TP53
8 prostatic hyperplasia, benign 10.6 AR FOLH1 KLK3 PSCA
9 bartholin's duct cyst 10.6 AR TP53
10 prostatitis 10.6 KLK3 MSMB NKX3-1
11 prostate disease 10.6 AMACR AR FOLH1 KLK3
12 atrophy of prostate 10.6 KLK3 TP53
13 small cell carcinoma 10.6 KLK3 PTEN TMPRSS2 TP53
14 prostate sarcoma 10.6 KLK3 NKX3-1
15 testicular germ cell tumor 10.6 AKT1 AR PTEN TP53
16 ductal carcinoma in situ 10.5 AKT1 AR TP53
17 malignant ovarian surface epithelial-stromal neoplasm 10.5 AKT1 AREG TP53
18 penis squamous cell carcinoma 10.5
19 paratesticular adenocarcinoma 10.5
20 adenocarcinoma of the penis 10.5
21 ovary epithelial cancer 10.5 AKT1 AREG TP53
22 salivary gland cancer 10.5 AKT1 AREG PTEN
23 pharynx cancer 10.5 AKT1 AREG TP53
24 reproductive system disease 10.5 AR AREG KLK3
25 ovarian cancer 1 10.5 AKT1 AREG PTEN TP53
26 endocrine gland cancer 10.5 AKT1 AR AREG TP53
27 female reproductive organ cancer 10.5 AKT1 AREG PTEN TP53
28 pancreas adenocarcinoma 10.5 AKT1 AREG TP53
29 gastrointestinal system cancer 10.5 AKT1 AREG PTEN TP53
30 female reproductive endometrioid cancer 10.5 PTEN TP53
31 nodular prostate 10.5 AR KLK3
32 cell type cancer 10.5 AKT1 AREG KLK3 PTEN TP53
33 penile cancer 10.4
34 pancreatic ductal adenocarcinoma 10.4 AKT1 AREG TP53
35 prostatic adenoma 10.4 AR KLK3
36 suppression of tumorigenicity 12 10.3 AMACR AR FOLH1 GRP KLK3 NKX3-1
37 brain cancer 10.1 AKT1 PTEN TP53
38 reproductive organ cancer 9.5 AKT1 AMACR AR AREG CYP17A1 FOLH1

Graphical network of the top 20 diseases related to Male Reproductive Organ Cancer:



Diseases related to Male Reproductive Organ Cancer

Symptoms & Phenotypes for Male Reproductive Organ Cancer

MGI Mouse Phenotypes related to Male Reproductive Organ Cancer:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 TMPRSS2 TP53 AKT1 AR AREG MSMB
2 adipose tissue MP:0005375 9.73 TP53 AKT1 AMACR AR CYP17A1 PTEN
3 neoplasm MP:0002006 9.56 TP53 AKT1 AR MSMB NKX3-1 PSCA
4 reproductive system MP:0005389 9.28 TMPRSS2 TP53 AKT1 AR AREG CYP17A1

Drugs & Therapeutics for Male Reproductive Organ Cancer

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Cancer

Cochrane evidence based reviews: genital neoplasms, male

Genetic Tests for Male Reproductive Organ Cancer

Anatomical Context for Male Reproductive Organ Cancer

Publications for Male Reproductive Organ Cancer

Variations for Male Reproductive Organ Cancer

Expression for Male Reproductive Organ Cancer

Search GEO for disease gene expression data for Male Reproductive Organ Cancer.

Pathways for Male Reproductive Organ Cancer

Pathways related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 AKT1 AR KLK3 NKX3-1 PTEN SHC4
2 12.52 AKT1 AR KLK3 NKX3-1 PTEN TP53
3
Show member pathways
12.34 AKT1 CYP17A1 PTEN SHC4
4
Show member pathways
12.34 AKT1 AREG SHC4 TP53
5
Show member pathways
12.33 AKT1 AREG SHC4 TP53
6
Show member pathways
12.1 AKT1 PSMA1 PTEN TP53
7
Show member pathways
12.06 AKT1 AREG PTEN SHC4
8 11.89 AKT1 AR PTEN TP53
9
Show member pathways
11.83 AKT1 AR KLK3 PTEN
10 11.8 PTEN RNASEL TP53
11 11.72 AKT1 PTEN TP53
12 11.67 AKT1 PTEN TP53
13 11.54 AKT1 PTEN TP53
14 11.53 AKT1 PTEN TP53
15 11.52 AKT1 AR KLK3 PTEN
16 11.4 AKT1 PTEN TP53
17 11.33 KLK2 KLK3 KLK4
18
Show member pathways
11.3 AR KLK3 NKX3-1
19 11.27 AKT1 PTEN TP53
20 10.96 AR KLK2 KLK3 TMPRSS2
21 10.86 AKT1 AR KLK2 KLK3 NKX3-1 TMPRSS2

GO Terms for Male Reproductive Organ Cancer

Biological processes related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.91 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
2 protein deubiquitination GO:0016579 9.81 AR PSMA1 PTEN TP53
3 cell proliferation GO:0008283 9.72 AKT1 AR AREG PTEN TP53
4 negative regulation of epithelial cell proliferation GO:0050680 9.54 AR NKX3-1 PTEN
5 prostate gland development GO:0030850 9.52 AR NKX3-1
6 response to inorganic substance GO:0010035 9.49 PTEN TP53
7 cellular response to steroid hormone stimulus GO:0071383 9.48 AR NKX3-1
8 negative regulation of cell size GO:0045792 9.46 AKT1 PTEN
9 protein kinase B signaling GO:0043491 9.43 AKT1 NKX3-1 PTEN
10 positive regulation of cell proliferation GO:0008284 9.43 AKT1 AR AREG NKX3-1 PTEN SHC4
11 prostate gland growth GO:0060736 9.4 AR PTEN
12 cellular response to decreased oxygen levels GO:0036294 9.16 AKT1 PTEN
13 cellular response to hypoxia GO:0071456 8.92 AKT1 NKX3-1 PTEN TP53

Molecular functions related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.86 FOLH1 KLK2 KLK3 KLK4 PSMA1 PTEN
2 serine-type endopeptidase activity GO:0004252 9.62 KLK2 KLK3 KLK4 TMPRSS2
3 serine-type peptidase activity GO:0008236 9.46 KLK2 KLK3 KLK4 TMPRSS2
4 peptidase activity GO:0008233 9.43 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
5 androgen receptor activity GO:0004882 8.62 AR NKX3-1

Sources for Male Reproductive Organ Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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