MCID: MLR006
MIFTS: 38

Male Reproductive Organ Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Male Reproductive Organ Cancer

MalaCards integrated aliases for Male Reproductive Organ Cancer:

Name: Male Reproductive Organ Cancer 12 14
Genital Neoplasms, Male 42 69
Malignant Neoplasm of Male Genital Organ, Site Unspecified 12
Malignant Neoplasm of Male Genital Organ, Unspecified 12
Malignant Neoplasm of Male Genital Organ or Tract 12
Malignant Neoplasm of Male Genital Organ, Nos 12
Malignant Tumor of Male Reproductive System 12
Malignant Neoplasm of Male Genital Organs 12
Malignant Tumor of Male Genital Organ 12
Male Reproductive System Neoplasm 12
Tumor of Male Reproductive System 12
Neoplasm of Male Genital Organ 12
Male Genital Neoplasm 12
Male Genital Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3856
ICD9CM 35 187.9
MeSH 42 D005834
NCIt 47 C3054 C8561

Summaries for Male Reproductive Organ Cancer

Disease Ontology : 12 A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.

MalaCards based summary : Male Reproductive Organ Cancer, also known as genital neoplasms, male, is related to prostate cancer and seminal vesicle adenocarcinoma. An important gene associated with Male Reproductive Organ Cancer is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Metabolism of proteins and Phospholipase-C Pathway. The drugs Goserelin and Leuprolide have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related phenotypes are endocrine/exocrine gland and adipose tissue

Related Diseases for Male Reproductive Organ Cancer

Diseases related to Male Reproductive Organ Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
id Related Disease Score Top Affiliating Genes
1 prostate cancer 30.3 AKT1 AMACR AR CYP17A1 FOLH1 GRP
2 seminal vesicle adenocarcinoma 10.9
3 littre gland carcinoma 10.9
4 cowper gland carcinoma 10.9
5 pulmonary embolism and infarction 10.9 AR TP53
6 fibular collateral ligament bursitis 10.9 AMACR KLK3 NKX3-1
7 brenner tumor of the vagina 10.9 CYP17A1 PTEN TP53
8 brenner tumor of ovary 10.9 CYP17A1 PTEN TP53
9 sarcomatoid renal cell carcinoma 10.9 AMACR KLK3 TP53
10 malt worker's lung 10.9 KLK3 TP53
11 mucinous adenocarcinoma 10.9 AMACR AR KLK3 TMPRSS2
12 gallbladder sarcoma 10.9 KLK3 NKX3-1
13 infratentorial cancer 10.9 AMACR AR FOLH1 KLK3
14 prostate cancer, hereditary, x-linked 1 10.8 AKT1 AR PTEN TP53
15 dental caries 10.8 AKT1 AREG TP53
16 avoidant personality disorder 10.8 AR AREG KLK3
17 nasal cavity disease 10.8 AKT1 AREG TP53
18 integumentary system cancer 10.8 AKT1 AREG TP53
19 pulmonary subvalvular stenosis 10.8 AKT1 AREG PTEN
20 pancreatic somatostatinoma 10.8 AKT1 AREG TP53
21 breast myoepithelial neoplasm 10.8 PTEN TP53
22 benign shuddering attacks 10.8 AKT1 AR AREG TP53
23 trachea squamous cell carcinoma 10.7 AKT1 AREG PTEN TP53
24 plague 10.7 IGF1 KLK3 TP53
25 gallbladder cancer 10.7 AKT1 AREG PTEN TP53
26 brachyolmia 10.7 GRP KLK3 PTEN TMPRSS2 TP53
27 brown-vialetto-van laere syndrome 10.7 AKT1 AREG KLK3 PTEN TP53
28 rectum squamous cell carcinoma 10.6 AKT1 TP53
29 pulmonary fibrosis, idiopathic susceptibility 10.6 AR CYP17A1 KLK3 NKX3-1 PTEN RNASEL
30 paroxysmal nocturnal hemoglobinuria 10.6 AKT1 AREG TP53
31 nail disorder, nonsyndromic congenital, 1 10.6 KLK3 PTEN TP53
32 splenic infarction 10.6 AMACR AR FOLH1 KLK3 PTEN TMPRSS2
33 prostate cancer 1 10.5 RNASEL TMPRSS2
34 testicular germ cell tumor 10.4
35 penis squamous cell carcinoma 10.4
36 paratesticular adenocarcinoma 10.4
37 adenocarcinoma of penis 10.4
38 hole retinal cyst 10.4 AR KLK3
39 penile cancer 10.4
40 lethal congenital contracture syndrome 10 10.3 AKT1 AR IGF1 PTEN TP53
41 bardet-biedl syndrome 9.0 AKT1 AMACR AR AREG CYP17A1 FOLH1
42 medullomyoblastoma 8.8 AKT1 AMACR AR AREG CYP17A1 FOLH1

Graphical network of the top 20 diseases related to Male Reproductive Organ Cancer:



Diseases related to Male Reproductive Organ Cancer

Symptoms & Phenotypes for Male Reproductive Organ Cancer

MGI Mouse Phenotypes related to Male Reproductive Organ Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 AKT1 AR AREG IGF1 NKX3-1 PTEN
2 adipose tissue MP:0005375 9.73 TP53 AKT1 AMACR AR IGF1 PTEN
3 neoplasm MP:0002006 9.56 AKT1 AR IGF1 NKX3-1 PSCA PTEN
4 reproductive system MP:0005389 9.28 AKT1 AR AREG CYP17A1 IGF1 NKX3-1

Drugs & Therapeutics for Male Reproductive Organ Cancer

Drugs for Male Reproductive Organ Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Goserelin Approved Phase 2 65807-02-5 47725 5311128
2
Leuprolide Approved, Investigational Phase 2 53714-56-0 3911 657181
3
Prednisone Approved, Vet_approved Phase 2 53-03-2 5865
4
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
5
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
6
acetic acid Approved, Nutraceutical Phase 2 64-19-7 176
7
Docetaxel Approved May 1996, Investigational Phase 2 114977-28-5 148124 9877265
8 Gossypol Investigational Phase 2 303-45-7
9
Abiraterone acetate Phase 2 154229-18-2 57336518
10 Anti-Inflammatory Agents Phase 2
11 Antineoplastic Agents, Hormonal Phase 2
12 Contraceptive Agents Phase 2
13 Cytochrome P-450 Enzyme Inhibitors Phase 2
14 Fertility Agents Phase 2
15 glucocorticoids Phase 2
16 Hormone Antagonists Phase 2
17 Hormones Phase 2
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
19 Luteolytic Agents Phase 2
20 Prolactin Release-Inhibiting Factors Phase 2
21 Steroid Synthesis Inhibitors Phase 2
22 Triptorelin Pamoate Phase 2
23 Antimitotic Agents Phase 2
24 Antineoplastic Agents, Phytogenic Phase 2
25 Contraceptive Agents, Male Phase 2
26 Gossypol acetic acid Phase 2
27
Retinol acetate Phase 2 127-47-9 10245972
28 Spermatocidal Agents Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Effects of Apalutamide Plus LHRH Agonist or Apalutamide Plus Abiraterone Acetate Plus LHRH Agonist for Six Months for Prostate Cancer Patients at High Risk for Recurrence Recruiting NCT03279250 Phase 2 LHRH Agonist;Apalutamide;Abiraterone Acetate;Prednisone
2 Chemotherapy AND Bcl-xL Inhibitor (AT-101) For Organ Preservation In Adults With Advanced Laryngeal Cancer Recruiting NCT01633541 Phase 2 AT-101;Docetaxel;Cisplatin;Carboplatin
3 Study to Assess the Non-inferiority of Pamorelin® 11,25mg SC Injected Versus Pamorelin® 11,25mg IM Injected in Patients Suffering From Advanced Prostate Cancer (PAMOJECT) Terminated NCT00444639 Phase 2 Triptorelin (Decapeptyl®)
4 Ano-genital Human Papillomavirus (HPV) Infection, Precancerous Lesions and Genital Warts Among Danish Renal Transplant Recipients Recruiting NCT03018327

Search NIH Clinical Center for Male Reproductive Organ Cancer

Cochrane evidence based reviews: genital neoplasms, male

Genetic Tests for Male Reproductive Organ Cancer

Anatomical Context for Male Reproductive Organ Cancer

MalaCards organs/tissues related to Male Reproductive Organ Cancer:

39
Prostate

Publications for Male Reproductive Organ Cancer

Variations for Male Reproductive Organ Cancer

Expression for Male Reproductive Organ Cancer

Search GEO for disease gene expression data for Male Reproductive Organ Cancer.

Pathways for Male Reproductive Organ Cancer

Pathways related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.71 AR AREG GRP IGF1 KLK2 KLK3
2
Show member pathways
12.98 AKT1 AREG IGF1 PSMA1 PTEN TP53
3
Show member pathways
12.42 AKT1 AREG SHC4 TP53
4
Show member pathways
12.39 AKT1 CYP17A1 PTEN SHC4
5
Show member pathways
12.3 AKT1 IGF1 PTEN TP53
6
Show member pathways
12.28 AKT1 AR IGF1 KLK3 NKX3-1 PTEN
7
Show member pathways
12.22 AKT1 AREG SHC4 TP53
8
Show member pathways
12.14 AKT1 PSMA1 PTEN TP53
9
Show member pathways
12.11 AKT1 AREG PTEN SHC4
10 12.1 AKT1 AR IGF1 KLK3 NKX3-1 PTEN
11 11.98 AKT1 AR PTEN TP53
12
Show member pathways
11.82 AKT1 AR IGF1 KLK3 PTEN
13 11.8 AKT1 IGF1 PTEN TP53
14 11.76 IGF1 PTEN RNASEL TP53
15 11.73 AKT1 PTEN TP53
16 11.73 AKT1 PTEN TP53
17 11.66 AKT1 AR KLK3 PTEN
18 11.59 AKT1 PTEN TP53
19 11.58 AKT1 PTEN TP53
20 11.54 IGF1 KLK2 KLK3
21 11.46 AKT1 PTEN TP53
22 11.39 KLK2 KLK3 KLK4
23
Show member pathways
11.36 AR KLK3 NKX3-1
24 11.35 AKT1 PTEN TP53
25 11.16 AR KLK2 KLK3 TMPRSS2
26 11.14 AKT1 IGF1 PTEN
27 10.87 IGF1 KLK2 KLK3
28 10.86 AKT1 AR KLK2 KLK3 NKX3-1 TMPRSS2

GO Terms for Male Reproductive Organ Cancer

Biological processes related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.93 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
2 protein deubiquitination GO:0016579 9.86 AR PSMA1 PTEN TP53
3 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.7 AREG IGF1 TP53
4 cell proliferation GO:0008283 9.63 AKT1 AR AREG IGF1 PTEN TP53
5 phosphatidylinositol-mediated signaling GO:0048015 9.62 AKT1 IGF1 PTEN TP53
6 negative regulation of epithelial cell proliferation GO:0050680 9.61 AR NKX3-1 PTEN
7 prostate gland development GO:0030850 9.57 AR NKX3-1
8 cellular response to hypoxia GO:0071456 9.56 AKT1 NKX3-1 PTEN TP53
9 positive regulation of glycogen biosynthetic process GO:0045725 9.55 AKT1 IGF1
10 insulin-like growth factor receptor signaling pathway GO:0048009 9.54 AKT1 IGF1
11 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.51 AR IGF1
12 cellular response to steroid hormone stimulus GO:0071383 9.49 AR NKX3-1
13 negative regulation of cell size GO:0045792 9.48 AKT1 PTEN
14 positive regulation of cell proliferation GO:0008284 9.43 AR AREG IGF1 NKX3-1 PTEN SHC4
15 prostate gland growth GO:0060736 9.4 AR PTEN
16 cellular response to decreased oxygen levels GO:0036294 9.37 AKT1 PTEN
17 protein kinase B signaling GO:0043491 8.92 AKT1 IGF1 NKX3-1 PTEN

Molecular functions related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.86 FOLH1 KLK2 KLK3 KLK4 PSMA1 PTEN
2 serine-type endopeptidase activity GO:0004252 9.62 KLK2 KLK3 KLK4 TMPRSS2
3 serine-type peptidase activity GO:0008236 9.46 KLK2 KLK3 KLK4 TMPRSS2
4 peptidase activity GO:0008233 9.43 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
5 androgen receptor activity GO:0004882 8.62 AR NKX3-1

Sources for Male Reproductive Organ Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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