MCID: MLG039
MIFTS: 30

Malignant Essential Hypertension malady

Categories: Genetic diseases, Cardiovascular diseases, Blood diseases, Rare diseases

Aliases & Classifications for Malignant Essential Hypertension

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Aliases & Descriptions for Malignant Essential Hypertension:

Name: Malignant Essential Hypertension 11 13 68
 
Accelerated Essential Hypertension 11

Classifications:



External Ids:

Disease Ontology11 DOID:10823
ICD9CM32 401.0
SNOMED-CT62 1218009, 78975002
NCIt45 C34802

Summaries for Malignant Essential Hypertension

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MalaCards based summary: Malignant Essential Hypertension, also known as accelerated essential hypertension, is related to mosaic genome-wide paternal uniparental disomy and internuclear ophthalmoplegia. An important gene associated with Malignant Essential Hypertension is KLKB1 (Kallikrein B1), and among its related pathways are MSP-RON Signaling and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics.

Related Diseases for Malignant Essential Hypertension

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Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 7
Hypertension, Essential 8 malignant essential hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Malignant Essential Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1mosaic genome-wide paternal uniparental disomy10.4HBB, HBD
2internuclear ophthalmoplegia10.4HBB, HBD
3cyanosis, transient neonatal10.4HBB, HBD
4intracranial cavernous angioma10.4HBB, HBD
5vulvar proximal-type epithelioid sarcoma10.4HBB, HBD
6congenital nonspherocytic hemolytic anemia10.4HBB, HBD
7thrombotic thrombocytopenic purpura10.4HLA-A, REN
8meibomian cyst10.4HLA-A, KLK4
9fatal infantile hypertrophic cardiomyopathy due to mitochondrial complex i deficiency10.4ACE, AGTR2
10hypotelorism cleft palate hypospadias10.3ACE, REN
11cystic kidney disease10.3ACE, REN
12post-infectious myocarditis10.3ACE, AGTR2
13hypodermyasis10.3ACE, REN
14atrial septal defect 7, with or without av conduction defects10.3ACE, REN
15plasmodium malariae malaria10.3HBB, HBD
16ovarian cancer10.3ACE, REN
17bartholin's duct cyst10.3HLA-A, TNFRSF25
18antiphospholipid syndrome10.3ACE, REN
19dressler's syndrome10.3REN, TNFRSF25
20chylocele of tunica vaginalis10.2ACE, REN
21degenerative myopia10.2ACE, REN
22mental depression10.2ACE, REN
23glucosephosphate dehydrogenase deficiency10.2HBB, HBD
24plica syndrome10.2ACE, REN
25renal tubular dysgenesis10.2ACE, REN
26benign neonatal seizures10.1ACE, REN
27autoimmune disease of endocrine system10.1KLKB1, KNG1
28cd3zeta deficiency10.1HLA-A, TNFRSF25
29gastric adenosquamous carcinoma10.1ACE, SAMHD1
30adenocarcinoma10.1ACE, REN
31childhood malignant mesenchymoma10.1HBB, HBD
32chronic inflammatory demyelinating polyneuritis10.0HBB, SAMHD1
33autonomic neuropathy10.0ACE, SAMHD1
34collecting duct carcinoma10.0ACE, REN
35kidney hypertrophy10.0ACE, AGTR2
36trochlear nerve neoplasm10.0ACE, SAMHD1
37chronic closed-angle glaucoma9.9KLK4, KNG1
38chondromalacia9.9ACE, SAMHD1
39chronic diarrhea due to guanylate cyclase 2c overactivity9.9ACE, KNG1
40central nervous system angiosarcoma9.9ACE, REN
41chilblain lupus9.8SAMHD1, TNFRSF25
42dermatomycosis9.7ACE, KLKB1, KNG1
43cystinosis9.7ACE, REN
44arteriosclerosis9.6
45aneurysm9.6
46craniosynostosis9.6ACE, KNG1, REN
47gemistocytic astrocytoma9.6ACE, KNG1, REN
48adrenal rest tumor9.6ACE, KNG1, REN
49peripheral artery disease9.5ACE, KNG1, REN
50hepatic adenoma, somatic9.4ACE, HLA-A, REN, TNFRSF25

Comorbidity relations with Malignant Essential Hypertension via Phenotypic Disease Network (PDN):

(show all 36)
Anxiety DisorderDeficiency Anemia
Hypertensive RetinopathyHypothyroidism
Iron Deficiency AnemiaActive Peptic Ulcer Disease
Acute CystitisAcute Kidney Failure
AphasiaBasilar Artery Insufficiency
Benign Essential HypertensionBronchitis
Cerebral AtherosclerosisChronic Kidney Failure
Coronary Artery DiseaseEsophagitis
Familial Atrial FibrillationFirst-Degree Atrioventricular Block
Generalized AtherosclerosisHeart Disease
Hypertension, EssentialHypertensive Encephalopathy
Intermediate Coronary SyndromeIschemic Heart Disease
Left Ventricular Outflow Tract ObstructionMalignant Renovascular Hypertension
Mitral Valve DiseasePeripheral Vascular Disease
Primary HyperoxaluriaRenal Artery Atheroma
Respiratory FailureSinoatrial Node Disease
Swallowing DisordersTransient Cerebral Ischemia
Vertebral Artery InsufficiencySchizophreniform Disorder

Graphical network of the top 20 diseases related to Malignant Essential Hypertension:



Diseases related to malignant essential hypertension

Symptoms & Phenotypes for Malignant Essential Hypertension

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Drugs & Therapeutics for Malignant Essential Hypertension

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Drugs for Malignant Essential Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VerapamilapprovedPhase 212552-53-92520
Synonyms:
(+-)-Verapamil
(+/-)-VERAPAMIL
(1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile
2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
52-53-9
56949-77-0
AB00053495
AC-16016
AC1L1DV5
Akilen
Anpec
Apo-Verap
Arpamyl
Arpamyl LP
BPBio1_000268
BRD-A09533288-001-02-7
BRD-A09533288-003-05-6
BSPBio_000242
BSPBio_001513
BSPBio_002358
Berkatens
Bio-0754
Bio1_000425
Bio1_000914
Bio1_001403
Bio2_000233
Bio2_000713
C07188
C27H38N2O4
CCRIS 6749
CHEBI:9948
CHEMBL6966
CID2520
CP-16533-1
CP-165331
Calan
Calan SR
Calan sr
Calaptin
Calaptin 240 SR
Calcan
Cardiabeltin
Cardiagutt
Cardibeltin
Cardioprotect
Caveril
Civicor
Civicor Retard
Coraver
Cordilox
Cordilox SR
Corpamil
Covera-HS
Covera-Hs
Covera-hs
D-365
D02356
DB00661
Dexverapamil
Dignover
Dilacoran
Dilacoran HTA
DivK1c_000399
Drosteakard
Durasoptin
EINECS 200-145-1
EINECS 260-462-6
Elthon
FT-0080127
Falicard
Finoptin
Flamon
Geangin
HMS1791L15
HMS1989L15
HMS2089H17
Harteze
Hexasoptin
Hexasoptin Retard
Hormitol
I06-0063
IDI1_000399
IDI1_033983
Ikacor
Ikapress
Inselon
Iproveratril
Isoptimo
Isoptin
Isoptin Retard
Isoptin SR
Isoptin sr
Isoptine
Isoptino
Isotopin
Izoptin
Jenapamil
KBio1_000399
KBio2_000233
KBio2_002343
KBio2_002801
KBio2_004911
KBio2_005369
KBio2_007479
KBio3_000465
KBio3_000466
 
KBio3_002823
KBioGR_000233
KBioGR_001372
KBioGR_002343
KBioSS_000233
KBioSS_002346
L001330
LS-174
Lekoptin
Lodixal
Lopac0_001237
Magotiron
Manidon
Manidon Retard
MolPort-000-721-258
NCGC00016083-14
NCGC00024710-04
NCGC00024710-05
NCGC00024710-06
NCGC00024710-07
NCGC00024710-08
NCGC00024710-09
NCI60_020143
NINDS_000399
NSC272366
NU-Verap
Novapamyl LP
Novo-Veramil
Nu-Verap
Ormil
Praecicor
Prestwick0_000141
Prestwick1_000141
Prestwick2_000141
Prestwick3_000141
Quasar
Rapam
Robatelan
SPBio_001820
SPBio_002181
STK538085
Securon
Spectrum2_001740
Spectrum4_000906
Spectrum5_001786
Tarka
UNII-CJ0O37KU29
Univer
Univex
VERAPAMIL
Vasolan
Vasomil
Vasopten
Vera-Sanorania
Verabeta
Veracaps SR
Veracim
Veracor
Verahexal
Veraloc
Veramex
Veramil
Verapamil
Verapamil (USAN/INN)
Verapamil AL
Verapamil Acis
Verapamil Atid
Verapamil Basics
Verapamil Ebewe
Verapamil HCl
Verapamil Henning
Verapamil Injection
Verapamil MSD
Verapamil NM
Verapamil NM Pharma
Verapamil Nordic
Verapamil PB
Verapamil Riker
Verapamil SR
Verapamil Verla
Verapamil [USAN:BAN:INN]
Verapamil [USAN:INN:BAN]
Verapamil [Usan:Ban:Inn]
Verapamil-AbZ
Verapamilo
Verapamilo [INN-Spanish]
Verapamilum
Verapamilum [INN-Latin]
Verapin
Verapress 240 SR
Veraptin
Verasal
Verasifar
Veratensin
Verdilac
Verelan
Verelan PM
Verelan SR
Verexamil
Veroptinstada
Verpamil
Vetrimil
Vortac
Vérapamil
alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
cMAP_000023
delta-365
nchembio.368-comp2
nchembio.79-comp5
2
HydroxyureaapprovedPhase 2215127-07-13657
Synonyms:
1-HYDROXYUREA
127-07-1
4-03-00-00170 (Beilstein Handbook Reference)
55291_FLUKA
AC1L1GF8
AC1Q4ZXK
AI3-51139
BB_SC-7256
BRN 1741548
BSPBio_002164
Bio1_000451
Bio1_000940
Bio1_001429
Biosupressin
C07044
CCRIS 958
CHEBI:44423
CHEMBL467
CID3657
Carbamohydroxamic Acid
Carbamohydroxamic acid
Carbamohydroximic Acid
Carbamohydroximic acid
Carbamohydroxyamic Acid
Carbamohydroxyamic acid
Carbamoyl Oxime
Carbamoyl oxime
Carbamyl Hydroxamate
Carbamyl hydroxamate
Carrbamoyl Oxime
D00341
D006918
DB01005
DRG-0253
DivK1c_000556
Droxia
Droxia (TM)
Droxia (TN)
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
EINECS 204-821-7
EU-0100596
FT-0083575
H 8627
H0310
H20210
H8627_SIGMA
HMS1920F09
HMS2091L17
HMS501L18
HSDB 6887
HU
HYDREA (TN)
HYDROXY-UREA
Hidrix
Hidroxicarbamida
Hidroxicarbamida [INN-Spanish]
Hydrea
Hydrea (TM)
Hydrea, Biosupressin, Cytodrox, Hydroxyurea
Hydreia
Hydroxicarbamidum
Hydroxycarbamid
Hydroxycarbamide
Hydroxycarbamide (JAN/INN)
Hydroxycarbamidum
Hydroxycarbamidum [INN-Latin]
Hydroxycarbamine
Hydroxyharnstoff
Hydroxyharnstoff [German]
Hydroxylurea
Hydroxyurea
Hydroxyurea (D4)
Hydroxyurea (USP)
Hydroxyurea [USAN:BAN]
Hydroxyurea(d4)
 
Hydura
Hydurea
I05-0250
IDI1_000556
Idrossicarbamide
Idrossicarbamide [DCIT]
Idrossicarbamide [Dcit]
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
KBioGR_000383
KBioSS_001389
LS-709
Litaler
Litalir
Lopac-H-8627
Lopac0_000596
MLS001332381
MLS001332382
MLS002153389
MolMap_000029
MolPort-000-003-971
Mylocel
N-(Aminocarbonyl) Hydroxyamine
N-Carbamoylhydroxylamine
N-HYDROXY UREA
N-Hydroxymocovina
N-Hydroxymocovina [Czech]
N-Hydroxyurea
NCGC00015520-01
NCGC00015520-02
NCGC00015520-07
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCI C04831
NCI-C04831
NCI60_002773
NCIMech_000139
NHY
NINDS_000556
NSC 32065
NSC32065
Onco-Carbide
Onco-carbide
Oncocarbide
Oxyurea
S-phase/G-1 interface inhibitor
S1896_Selleck
SK 22591
SMR000059149
SPBio_000247
SPECTRUM1500344
SQ 1089
SQ-1089
Siklos
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Spectrum_000909
Sterile Urea
TL8000673
UNII-X6Q56QN5QC
Ureaphil
WLN: ZVMQ
carbamide oxide
hydroxyaminomethanamide
hydroxyurea
nchembio.573-comp3
nchembio.90-comp4
nchembio749-comp3
tetratogen: inhibits ribonucleoside diphosphate reductase
3calcium channel blockersPhase 21940
4Vasodilator AgentsPhase 23438
5Nucleic Acid Synthesis InhibitorsPhase 24855
6Anti-Arrhythmia AgentsPhase 22969
7Calcium, DietaryPhase 25525

Interventional clinical trials:

idNameStatusNCT IDPhase
1Combination of Hydroxyurea and Verapamil for Refractory MeningiomasCompletedNCT00706810Phase 2
2Assessing Blood Pressure Remotely in Childhood Cancer SurvivorsCompletedNCT02476162

Search NIH Clinical Center for Malignant Essential Hypertension

Genetic Tests for Malignant Essential Hypertension

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Anatomical Context for Malignant Essential Hypertension

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Publications for Malignant Essential Hypertension

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Articles related to Malignant Essential Hypertension:

(show all 13)
idTitleAuthorsYear
1
Human leukocyte antigens and malignant essential hypertension. (9657633)
1998
2
Does non-malignant essential hypertension cause renal damage? A clinician's view. (9004097)
1996
3
Urinary kallikrein excretion is low in malignant essential hypertension. (1325521)
1992
4
Renal haemodynamics and comparative effects of captopril in patients with benign- or malignant-essential hypertension, or with chronic renal failure. (3301082)
1987
5
Predisposing factors for the development of malignant essential hypertension. (3662703)
1987
6
Prospective measurement of glomerular filtration rate and effective renal plasma flow during treatment of malignant essential hypertension. (6494086)
1984
7
Renal function as an indicator of prognosis in malignant essential hypertension. (7089493)
1982
8
Immunological changes in patients with previous malignant essential hypertension. (6110039)
1981
9
Vascular lesions of malignant essential hypertension. (5567956)
1971
10
Vascular lesions of malignant essential hypertension. (5567174)
1971
11
Vascular lesions of malignant essential hypertension. (5504381)
1970
12
Successful twin pregnancy after treatment of malignant essential hypertension. (13572832)
1958
13
Clinicopathologic conference; generalized arteriosclerosis; malignant essential hypertension with dissecting aneurysm of the artery and coronary occlusion. (15426209)
1950

Variations for Malignant Essential Hypertension

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Expression for genes affiliated with Malignant Essential Hypertension

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Search GEO for disease gene expression data for Malignant Essential Hypertension.

Pathways for genes affiliated with Malignant Essential Hypertension

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Pathways related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.9KLK4, KLKB1
2
Show member pathways
8.4ACE, AGTR2, KNG1, REN

GO Terms for genes affiliated with Malignant Essential Hypertension

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Cellular components related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hemoglobin complexGO:000583310.5HBB, HBD
2blood microparticleGO:00725629.7HBB, HBD, KNG1
3extracellular regionGO:00055767.6ACE, AGTR2, HBB, KLK4, KLKB1, KNG1
4plasma membraneGO:00058866.6ACE, AGTR2, HLA-A, KLKB1, KNG1, REN

Biological processes related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:001567110.3HBB, HBD
2protein catabolic processGO:003016310.2KLK4, REN
3positive regulation of nitric oxide biosynthetic processGO:004542910.2AGTR2, HBB
4blood vessel remodelingGO:000197410.2ACE, AGTR2
5angiotensin maturationGO:000200310.2ACE, REN
6beta-amyloid metabolic processGO:005043510.2ACE, REN
7antigen processing and presentation of peptide antigen via MHC class IGO:000247410.1ACE, HLA-A
8blood coagulation, intrinsic pathwayGO:000759710.0KLKB1, KNG1
9positive regulation of renal sodium excretionGO:00358159.9AGTR2, KNG1
10renin-angiotensin regulation of aldosterone productionGO:00020189.8AGTR2, REN
11regulation of blood pressureGO:00082178.9ACE, AGTR2, HBB, REN

Molecular functions related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1oxygen bindingGO:001982510.0HBB, HBD
2oxygen transporter activityGO:00053449.7HBB, HBD

Sources for Malignant Essential Hypertension

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet