MCID: MLG039
MIFTS: 29

Malignant Essential Hypertension malady

Categories: Genetic diseases, Cardiovascular diseases, Blood diseases, Rare diseases

Aliases & Classifications for Malignant Essential Hypertension

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Aliases & Descriptions for Malignant Essential Hypertension:

Name: Malignant Essential Hypertension 10 12 65
 
Accelerated Essential Hypertension 10

Classifications:



External Ids:

Disease Ontology10 DOID:10823
ICD9CM29 401.0
SNOMED-CT59 1218009, 78975002
NCIt42 C34802
UMLS65 C0024588

Summaries for Malignant Essential Hypertension

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MalaCards based summary: Malignant Essential Hypertension, also known as accelerated essential hypertension, is related to hypotrichosis-deafness syndrome and hemoglobin e disease. An important gene associated with Malignant Essential Hypertension is KLKB1 (Kallikrein B1), and among its related pathways are Antigen Presentation- Folding, assembly and peptide loading of class I MHC and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. Affiliated tissues include bone, smooth muscle and liver.

Related Diseases for Malignant Essential Hypertension

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Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 7
Hypertension, Essential 8 malignant essential hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Malignant Essential Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 102)
idRelated DiseaseScoreTop Affiliating Genes
1hypotrichosis-deafness syndrome10.4HBB, HBD
2hemoglobin e disease10.4HBB, HBD
3cyanosis, transient neonatal10.4HBB, HBD
4chronic congestive splenomegaly10.4HBB, HBD
5basal cell carcinoma10.4HBB, HBD
6active peptic ulcer disease10.4HBB, HBD
7marantic endocarditis10.4HBB, HBD
8swayback10.4HBB, HBD
9hemoglobinopathy10.4HBB, HBD
10generalized anxiety disorder10.3HBB, HBD
11endometrial adenocarcinoma10.3HBB, HBD
12mental retardation, x-linked 310.3HBB, HBD
13orbital granuloma10.3REN, TNFRSF25
14autosomal dominant chondrodysplasia punctata10.2ARSE, HLA-B
15portal hypertension10.2HLA-A, REN
16idiopathic membranous glomerulonephritis10.2ACE, REN
17hyposmia nasal hypoplasia hypogonadism10.2ACE, REN
18kidney cortex necrosis10.2ACE, REN
19atrial septal defect 7, with or without av conduction defects10.2ACE, REN
20hypochromic microcytic anemia with iron overload10.2ACE, REN
21glandular cystitis10.2ACE, REN
22fibrosing mediastinitis10.2ACE, REN
23periventricular leukomalacia10.2HLA-A, HLA-B
24postinfectious encephalomyelitis10.2HLA-A, HLA-B
25iridocyclitis10.2HLA-A, HLA-B
26hydromyelia10.2HLA-A, HLA-B
27retinitis10.2HLA-A, HLA-B
28anthracosis10.2HLA-A, HLA-B
29psoriasis10.2HLA-A, HLA-B
30iga glomerulonephritis10.2ACE, REN
31undetermined early-onset epileptic encephalopathy10.2HLA-A, HLA-B
32intermediate uveitis10.2HLA-A, HLA-B
33acneiform dermatitis10.2HLA-A, HLA-B
34prostate malignant phyllodes tumor10.2HLA-A, HLA-B
35acquired thrombocytopenia10.2HLA-A, HLA-B
36lacrimal duct obstruction10.2HLA-A, HLA-B
37human herpesvirus 810.1HLA-A, HLA-B
38voyeurism10.1ACE, REN
39gonococcal iridocyclitis10.1HLA-A, HLA-B
40estrogen excess10.1HLA-A, HLA-B
41multicentric reticulohistiocytosis10.1ACE, REN
42noonan-like/multiple giant cell lesion syndrome10.1HLA-A, HLA-B
43lymphocytic choriomeningitis10.1HLA-A, HLA-B
44pulmonary nodular lymphoid hyperplasia10.1HLA-A, HLA-B
45root resorption10.1HLA-A, HLA-B
46renal tubular dysgenesis10.1ACE, REN
47cytoplasmic body myopathy10.1HLA-A, HLA-B
48hemolytic anemia10.1HLA-A, HLA-B
49cryptosporidiosis10.1HLA-A, HLA-B
50endogenous depression10.1ACE, REN

Graphical network of the top 20 diseases related to Malignant Essential Hypertension:



Diseases related to malignant essential hypertension

Symptoms for Malignant Essential Hypertension

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Drugs & Therapeutics for Malignant Essential Hypertension

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Drugs for Malignant Essential Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
VerapamilapprovedPhase 211752-53-92520
Synonyms:
(+-)-Verapamil
(+/-)-VERAPAMIL
(1)-3-(3,4-Dimethoxyphenyl)-6-((5,6-dimethoxyphenethyl)methylamino)hexane-3-carbonitrile
2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-(1-methylethyl) pentanenitrile
2-(3,4-dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile
5-((3,4-Dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
5-[(3,4-Dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxyphenyl)-2-isopropylvaleronitrile
52-53-9
56949-77-0
AB00053495
AC-16016
AC1L1DV5
Akilen
Anpec
Apo-Verap
Arpamyl
Arpamyl LP
BPBio1_000268
BRD-A09533288-001-02-7
BRD-A09533288-003-05-6
BSPBio_000242
BSPBio_001513
BSPBio_002358
Berkatens
Bio-0754
Bio1_000425
Bio1_000914
Bio1_001403
Bio2_000233
Bio2_000713
C07188
C27H38N2O4
CCRIS 6749
CHEBI:9948
CHEMBL6966
CID2520
CP-16533-1
CP-165331
Calan
Calan SR
Calan Sr
Calan sr
Calaptin
Calaptin 240 SR
Calcan
Cardiabeltin
Cardiagutt
Cardibeltin
Cardioprotect
Caveril
Civicor
Civicor Retard
Coraver
Cordilox
Cordilox SR
Corpamil
Covera-HS
Covera-Hs
Covera-hs
D-365
D02356
DB00661
Dexverapamil
Dignover
Dilacoran
Dilacoran HTA
DivK1c_000399
Drosteakard
Durasoptin
EINECS 200-145-1
EINECS 260-462-6
Elthon
FT-0080127
Falicard
Finoptin
Flamon
Geangin
HMS1791L15
HMS1989L15
HMS2089H17
Harteze
Hexasoptin
Hexasoptin Retard
Hormitol
I06-0063
IDI1_000399
IDI1_033983
Ikacor
Ikapress
Inselon
Iproveratril
Isoptimo
Isoptin
Isoptin Retard
Isoptin SR
Isoptin sr
Isoptine
Isoptino
Isotopin
Izoptin
Jenapamil
KBio1_000399
KBio2_000233
KBio2_002343
KBio2_002801
KBio2_004911
KBio2_005369
KBio2_007479
KBio3_000465
KBio3_000466
KBio3_002823
KBioGR_000233
 
KBioGR_001372
KBioGR_002343
KBioSS_000233
KBioSS_002346
L001330
LS-174
Lekoptin
Lodixal
Lopac0_001237
Magotiron
Manidon
Manidon Retard
MolPort-000-721-258
NCGC00016083-14
NCGC00024710-04
NCGC00024710-05
NCGC00024710-06
NCGC00024710-07
NCGC00024710-08
NCGC00024710-09
NCI60_020143
NINDS_000399
NSC272366
NU-Verap
Novapamyl LP
Novo-Veramil
Nu-Verap
Ormil
Praecicor
Prestwick0_000141
Prestwick1_000141
Prestwick2_000141
Prestwick3_000141
Quasar
Rapam
Robatelan
SID104171262
SID124881789
SID124881790
SPBio_001820
SPBio_002181
STK538085
Securon
Spectrum2_001740
Spectrum4_000906
Spectrum5_001786
Tarka
UNII-CJ0O37KU29
Univer
Univex
VERAPAMIL
Vasolan
Vasomil
Vasopten
Vera-Sanorania
Verabeta
Veracaps SR
Veracim
Veracor
Verahexal
Veraloc
Veramex
Veramil
Verapamil
Verapamil (USAN/INN)
Verapamil AL
Verapamil Acis
Verapamil Atid
Verapamil Basics
Verapamil Ebewe
Verapamil HCl
Verapamil Henning
Verapamil Hydrochloride
Verapamil Injection
Verapamil MSD
Verapamil NM
Verapamil NM Pharma
Verapamil Nordic
Verapamil PB
Verapamil Riker
Verapamil SR
Verapamil Verla
Verapamil [USAN:BAN:INN]
Verapamil [USAN:INN:BAN]
Verapamil [Usan:Ban:Inn]
Verapamil-AbZ
Verapamilo
Verapamilo [INN-Spanish]
Verapamilum
Verapamilum [INN-Latin]
Verapin
Verapress 240 SR
Veraptin
Verasal
Verasifar
Veratensin
Verdilac
Verelan
Verelan PM
Verelan Pm
Verelan SR
Verexamil
Veroptinstada
Verpamil
Vetrimil
Vortac
Vérapamil
alpha-((N-Methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
alpha-(3-((2-(3,4-Dimethoxyphenyl)ethyl)-methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile
alpha-Isopropyl-alpha-((N-methyl-N-homoveratryl)-gamma-aminopropyl)-3,4-dimethoxyphenylacetonitrile
cMAP_000023
delta-365
nchembio.368-comp2
nchembio.79-comp5
2
HydroxyureaapprovedPhase 2188127-07-13657
Synonyms:
1-HYDROXYUREA
127-07-1
4-03-00-00170 (Beilstein Handbook Reference)
55291_FLUKA
AC1L1GF8
AC1Q4ZXK
AI3-51139
BB_SC-7256
BRN 1741548
BSPBio_002164
Bio1_000451
Bio1_000940
Bio1_001429
Biosupressin
C07044
CCRIS 958
CHEBI:44423
CHEMBL467
CID3657
Carbamohydroxamic Acid
Carbamohydroxamic acid
Carbamohydroximic Acid
Carbamohydroximic acid
Carbamohydroxyamic Acid
Carbamohydroxyamic acid
Carbamoyl Oxime
Carbamoyl oxime
Carbamyl Hydroxamate
Carbamyl hydroxamate
Carrbamoyl Oxime
D00341
D006918
DB01005
DRG-0253
DivK1c_000556
Droxia
Droxia (TM)
Droxia (TN)
E0723DBA-5AF3-49D1-B5F6-59420AB87AC9
EINECS 204-821-7
EU-0100596
FT-0083575
H 8627
H0310
H20210
H8627_SIGMA
HMS1920F09
HMS2091L17
HMS501L18
HSDB 6887
HU
HYDREA (TN)
HYDROXY-UREA
Hidrix
Hidroxicarbamida
Hidroxicarbamida [INN-Spanish]
Hydrea
Hydrea (TM)
Hydrea, Biosupressin, Cytodrox, Hydroxyurea
Hydreia
Hydroxicarbamidum
Hydroxycarbamid
Hydroxycarbamide
Hydroxycarbamide (JAN/INN)
Hydroxycarbamidum
Hydroxycarbamidum [INN-Latin]
Hydroxycarbamine
Hydroxyharnstoff
Hydroxyharnstoff [German]
Hydroxylurea
Hydroxyurea
Hydroxyurea (D4)
Hydroxyurea (USP)
Hydroxyurea [USAN:BAN]
Hydroxyurea(d4)
 
Hydura
Hydurea
I05-0250
IDI1_000556
Idrossicarbamide
Idrossicarbamide [DCIT]
Idrossicarbamide [Dcit]
KBio1_000556
KBio2_001389
KBio2_003957
KBio2_006525
KBio3_001384
KBioGR_000383
KBioSS_001389
LS-709
Litaler
Litalir
Lopac-H-8627
Lopac0_000596
MLS001332381
MLS001332382
MLS002153389
MolMap_000029
MolPort-000-003-971
Mylocel
N-(Aminocarbonyl) Hydroxyamine
N-Carbamoylhydroxylamine
N-HYDROXY UREA
N-Hydroxymocovina
N-Hydroxymocovina [Czech]
N-Hydroxyurea
NCGC00015520-01
NCGC00015520-02
NCGC00015520-07
NCGC00093974-01
NCGC00093974-02
NCGC00093974-03
NCGC00093974-04
NCGC00093974-05
NCI C04831
NCI-C04831
NCI60_002773
NCIMech_000139
NHY
NINDS_000556
NSC 32065
NSC32065
Onco-Carbide
Onco-carbide
Oncocarbide
Oxyurea
S-phase/G-1 interface inhibitor
S1896_Selleck
SK 22591
SMR000059149
SPBio_000247
SPECTRUM1500344
SQ 1089
SQ-1089
Siklos
Spectrum2_000064
Spectrum3_000462
Spectrum4_000012
Spectrum5_000836
Spectrum_000909
Sterile Urea
TL8000673
UNII-X6Q56QN5QC
Ureaphil
WLN: ZVMQ
carbamide oxide
hydroxyaminomethanamide
hydroxyurea
nchembio.573-comp3
nchembio.90-comp4
nchembio749-comp3
tetratogen: inhibits ribonucleoside diphosphate reductase
3calcium channel blockersPhase 21743
4Vasodilator AgentsPhase 22926
5Nucleic Acid Synthesis InhibitorsPhase 23836
6Anti-Arrhythmia AgentsPhase 22371
7Calcium, DietaryPhase 24678

Interventional clinical trials:

idNameStatusNCT IDPhase
1Combination of Hydroxyurea and Verapamil for Refractory MeningiomasCompletedNCT00706810Phase 2
2Assessing Blood Pressure Remotely in Childhood Cancer SurvivorsCompletedNCT02476162

Search NIH Clinical Center for Malignant Essential Hypertension

Genetic Tests for Malignant Essential Hypertension

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Anatomical Context for Malignant Essential Hypertension

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MalaCards organs/tissues related to Malignant Essential Hypertension:

33
Bone, Smooth muscle, Liver

Animal Models for Malignant Essential Hypertension or affiliated genes

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MGI Mouse Phenotypes related to Malignant Essential Hypertension:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Malignant Essential Hypertension

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Articles related to Malignant Essential Hypertension:

(show all 13)
idTitleAuthorsYear
1
Melanotic Neuroectodermal Tumor of Infancy Arising in the Temporal Bone. (23965399)
2013
2
Methanol extract of Hydroclathrus clathratus suppresses matrix metalloproteinase-9 in T24 bladder carcinoma cells by suppressing the NF-I_B and MAPK pathways. (21993858)
2012
3
Genomics and genetics of gonadotropin beta-subunit genes: Unique FSHB and duplicated LHB/CGB loci. (20488225)
2010
4
Comparative analysis of outcomes in living and deceased donor liver transplants for primary sclerosing cholangitis. (19430850)
2009
5
Origin and distribution of tick-borne encephalitis virus strains of the Siberian subtype in the Middle Urals, the north-west of Russia and the Baltic countries. (19656959)
2009
6
Is video-game playing a risk factor for pathological gambling in Australian adolescents? (19578983)
2009
7
Interactive roles of fibroblast growth factor 2 and neurotrophin 3 in the sequence of migration, process outgrowth, and axonal differentiation of mouse cochlear ganglion cells. (18438927)
2008
8
Gliomatosis cerebri: improved outcome with radiotherapy. (12829152)
2003
9
Pure atmospheric pressure promotes an expression of osteopontin in human aortic smooth muscle cells. (11327728)
2001
10
Immunophenotypic analysis of the aortic wall in Takayasu's arteritis: involvement of lymphocytes, dendritic cells and granulocytes in immuno-inflammatory reactions. (10737351)
2000
11
Regulation of the 26S proteasome by adenovirus E1A. (10970867)
2000
12
Elevated nocturnal melatonin is a consequence of gonadotropin-releasing hormone deficiency in women with hypothalamic amenorrhea. (9768680)
1998
13
Nefazodone for mood disorder associated with epilepsy. (9921708)
1998

Variations for Malignant Essential Hypertension

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Expression for genes affiliated with Malignant Essential Hypertension

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Search GEO for disease gene expression data for Malignant Essential Hypertension.

Pathways for genes affiliated with Malignant Essential Hypertension

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Pathways related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4HLA-A, HLA-B
2
Show member pathways
8.6ACE, KNG1, REN

GO Terms for genes affiliated with Malignant Essential Hypertension

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Biological processes related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protection from natural killer cell mediated cytotoxicityGO:00422709.9HLA-A, HLA-B
2positive regulation of T cell mediated cytotoxicityGO:00019169.8HLA-A, HLA-B
3antigen processing and presentationGO:00198829.7HLA-A, HLA-B
4proteolysisGO:00065089.1ACE, KLKB1, REN

Molecular functions related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.4HLA-A, HLA-B

Sources for Malignant Essential Hypertension

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet