MCID: MLG039
MIFTS: 29

Malignant Essential Hypertension malady

Categories: Cardiovascular diseases, Genetic diseases, Blood diseases, Rare diseases

Aliases & Classifications for Malignant Essential Hypertension

Aliases & Descriptions for Malignant Essential Hypertension:

Name: Malignant Essential Hypertension 12 14 69
Accelerated Essential Hypertension 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10823
ICD9CM 35 401.0
NCIt 47 C34802
SNOMED-CT 64 1218009 78975002
UMLS 69 C0024588

Summaries for Malignant Essential Hypertension

MalaCards based summary : Malignant Essential Hypertension, also known as accelerated essential hypertension, is related to congenital pulmonary airway malformation and adult-onset multiple mitochondrial dna deletion syndrome due to dguok deficiency. An important gene associated with Malignant Essential Hypertension is KLKB1 (Kallikrein B1), and among its related pathways/superpathways is Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Verapamil and Hydroxyurea have been mentioned in the context of this disorder.

Related Diseases for Malignant Essential Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Malignant Essential Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Related Disease Score Top Affiliating Genes
1 congenital pulmonary airway malformation 10.3 AGTR2 REN
2 adult-onset multiple mitochondrial dna deletion syndrome due to dguok deficiency 10.3 HBB HBD
3 middle ear adenoma 10.3 HBB HBD
4 costello syndrome 10.2 HBB HBD
5 extrahepatic bile duct papillary adenoma 10.2 HBB HBD
6 endometrial adenocarcinoma 10.2 HBB HBD
7 gaba-transaminase deficiency 10.2 HBB HBD
8 mixed fibrolamellar hepatocellular carcinoma 10.2 HLA-A TNFRSF25
9 intracranial structure hemangioma 10.2 HBB HBD
10 hypopharynx cancer 10.2 HLA-A TNFRSF25
11 artemis deficiency 10.2 KLKB1 KNG1
12 malignant otitis externa 10.1 REN TNFRSF25
13 idiopathic panuveitis 10.1 ACE AGTR2
14 hypotrichosis simplex 10.1 ACE REN
15 rheumatic fever 10.1 KNG1 TNFRSF25
16 hyperinsulinemic hypoglycemia, familial, 3 10.1 ACE REN
17 carbohydrate metabolic disorder 10.1 ACE REN
18 leukocyte adhesion deficiency, type iii 10.1 KLK4 KLKB1 KNG1
19 hypothyroidism, congenital nongoitrous, 5 10.1 ACE REN
20 hypogonadism mitral valve prolapse mental retardation 10.1 ACE REN
21 listeriosis 10.1 ACE REN
22 dientamoebiasis 10.1 ACE REN
23 lymph node cancer 10.1 ENSG00000264813 KNG1
24 iris disease 10.0 ACE REN
25 preaxial polydactyly of fingers 10.0 ACE AGTR2
26 prostate neuroendocrine neoplasm 10.0 ACE REN
27 cascade stomach 10.0 ACE REN
28 tuberculous pneumothorax 10.0 ACE ENSG00000264813
29 hyperuricemic nephropathy, familial juvenile 2 10.0 ACE REN
30 hemorrhoid 10.0 ENSG00000264813 REN
31 mesenteric lymphadenitis 10.0 ACE ENSG00000264813
32 diffuse pulmonary fibrosis 10.0 ACE SAMHD1
33 omsk hemorrhagic fever 10.0 HLA-A KLK4
34 microphthalmia, isolated, with coloboma 7 10.0 ACE AGTR2 REN
35 eastern equine encephalitis 9.9 ACE REN
36 juvenile amyotrophic lateral sclerosis with dementia 9.9 ACE ENSG00000264813
37 myopia 9.9 ACE REN
38 flat umbilicus familial 9.9 ACE REN
39 secretory diarrhea myopathy and deafness 9.9 ACE KNG1
40 opiate dependence 9.9 ACE SAMHD1
41 peroneal neuropathy 9.9 ACE REN TNFRSF25
42 congenital nystagmus 9.9 ACE ENSG00000264813 REN
43 mechanical ectropion 9.9 ACE KLKB1 KNG1
44 red-green color blindness 9.8 ACE SAMHD1 TNFRSF25
45 critical limb ischemia 9.8 ACE KNG1 REN
46 hepatic infarction 9.8 AGTR2 HBB HBD KNG1 REN
47 pyrimidine metabolic disorder 9.7 ACE KNG1 REN
48 petrositis 9.7 ACE KLKB1 KNG1 REN
49 diabetes mellitus, insulin-dependent, 20 9.6 ACE HLA-A REN TNFRSF25
50 arteriosclerosis 9.6

Comorbidity relations with Malignant Essential Hypertension via Phenotypic Disease Network (PDN): (show all 38)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Anxiety Disorder
Basilar Artery Insufficiency Benign Essential Hypertension
Bronchitis Cerebral Atherosclerosis
Cerebrovascular Disease Chronic Kidney Failure
Chronic Myocardial Ischemia Deficiency Anemia
Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation Esophagitis
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Generalized Atherosclerosis Heart Disease
Hypertension, Essential Hypertensive Encephalopathy
Hypertensive Retinopathy Hypothyroidism
Intermediate Coronary Syndrome Intracranial Thrombosis
Iron Deficiency Anemia Ischemic Heart Disease
Kidney Disease Left Ventricular Outflow Tract Obstruction
Malignant Renovascular Hypertension Mitral Valve Disease
Peripheral Vascular Disease Renal Artery Atheroma
Respiratory Failure Schizophreniform Disorder
Sinoatrial Node Disease Swallowing Disorders
Transient Cerebral Ischemia Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Malignant Essential Hypertension:



Diseases related to Malignant Essential Hypertension

Symptoms & Phenotypes for Malignant Essential Hypertension

Drugs & Therapeutics for Malignant Essential Hypertension

Drugs for Malignant Essential Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Verapamil Approved Phase 2 52-53-9 2520
2
Hydroxyurea Approved Phase 2 127-07-1 3657
3 calcium channel blockers Phase 2
4 Nucleic Acid Synthesis Inhibitors Phase 2
5 Vasodilator Agents Phase 2
6 Anti-Arrhythmia Agents Phase 2
7 Calcium, Dietary Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Combination of Hydroxyurea and Verapamil for Refractory Meningiomas Completed NCT00706810 Phase 2
2 Assessing Blood Pressure Remotely in Childhood Cancer Survivors Completed NCT02476162

Search NIH Clinical Center for Malignant Essential Hypertension

Genetic Tests for Malignant Essential Hypertension

Anatomical Context for Malignant Essential Hypertension

Publications for Malignant Essential Hypertension

Articles related to Malignant Essential Hypertension:

(show all 13)
id Title Authors Year
1
Human leukocyte antigens and malignant essential hypertension. ( 9657633 )
1998
2
Does non-malignant essential hypertension cause renal damage? A clinician's view. ( 9004097 )
1996
3
Urinary kallikrein excretion is low in malignant essential hypertension. ( 1325521 )
1992
4
Renal haemodynamics and comparative effects of captopril in patients with benign- or malignant-essential hypertension, or with chronic renal failure. ( 3301082 )
1987
5
Predisposing factors for the development of malignant essential hypertension. ( 3662703 )
1987
6
Prospective measurement of glomerular filtration rate and effective renal plasma flow during treatment of malignant essential hypertension. ( 6494086 )
1984
7
Renal function as an indicator of prognosis in malignant essential hypertension. ( 7089493 )
1982
8
Immunological changes in patients with previous malignant essential hypertension. ( 6110039 )
1981
9
Vascular lesions of malignant essential hypertension. ( 5567174 )
1971
10
Vascular lesions of malignant essential hypertension. ( 5567956 )
1971
11
Vascular lesions of malignant essential hypertension. ( 5504381 )
1970
12
Successful twin pregnancy after treatment of malignant essential hypertension. ( 13572832 )
1958
13
Clinicopathologic conference; generalized arteriosclerosis; malignant essential hypertension with dissecting aneurysm of the artery and coronary occlusion. ( 15426209 )
1950

Variations for Malignant Essential Hypertension

Expression for Malignant Essential Hypertension

Search GEO for disease gene expression data for Malignant Essential Hypertension.

Pathways for Malignant Essential Hypertension

Pathways related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 ACE AGTR2 KNG1 REN

GO Terms for Malignant Essential Hypertension

Cellular components related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.33 HBB HBD KNG1
2 extracellular region GO:0005576 9.23 ACE AGTR2 HBB KLK4 KLKB1 KNG1
3 hemoglobin complex GO:0005833 8.96 HBB HBD

Biological processes related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.83 ACE ENSG00000264813 KLK4 KLKB1 REN
2 inflammatory response GO:0006954 9.8 AGTR2 KLKB1 KNG1 TNFRSF25
3 blood vessel remodeling GO:0001974 9.54 ACE AGTR2
4 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.52 ACE HLA-A
5 vasodilation GO:0042311 9.51 AGTR2 KNG1
6 blood coagulation, intrinsic pathway GO:0007597 9.48 KLKB1 KNG1
7 regulation of blood vessel size GO:0050880 9.46 HBB KNG1
8 blood coagulation GO:0007596 9.46 HBB HBD KLKB1 KNG1
9 oxygen transport GO:0015671 9.4 HBB HBD
10 beta-amyloid metabolic process GO:0050435 9.37 ACE REN
11 regulation of vasodilation GO:0042312 9.32 ACE AGTR2
12 angiotensin maturation GO:0002003 9.26 ACE REN
13 renin-angiotensin regulation of aldosterone production GO:0002018 8.96 AGTR2 REN
14 regulation of blood pressure GO:0008217 8.92 ACE AGTR2 HBB REN

Molecular functions related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.7 ACE ARSE ENSG00000264813 KLK4 KLKB1 REN
2 iron ion binding GO:0005506 9.54 HBB HBD KLKB1
3 heme binding GO:0020037 9.5 HBB HBD KLKB1
4 peptidase activity GO:0008233 9.35 ACE ENSG00000264813 KLK4 KLKB1 REN
5 oxygen transporter activity GO:0005344 9.26 HBB HBD
6 peptidyl-dipeptidase activity GO:0008241 8.62 ACE ENSG00000264813

Sources for Malignant Essential Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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