MCID: MLG014
MIFTS: 39

Malignant Fibrous Histiocytoma of Bone

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Malignant Fibrous Histiocytoma of Bone

MalaCards integrated aliases for Malignant Fibrous Histiocytoma of Bone:

Name: Malignant Fibrous Histiocytoma of Bone 12 14
Malignant Fibrous Histiocytoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3352
NCIt 47 C8563
UMLS 69 C0740479

Summaries for Malignant Fibrous Histiocytoma of Bone

MalaCards based summary : Malignant Fibrous Histiocytoma of Bone, also known as malignant fibrous histiocytoma of the bone, is related to histiocytoma and fibrous histiocytoma. An important gene associated with Malignant Fibrous Histiocytoma of Bone is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Apoptosis Modulation and Signaling and Endometrial cancer. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotypes are cardiovascular system and muscle

Related Diseases for Malignant Fibrous Histiocytoma of Bone

Diseases related to Malignant Fibrous Histiocytoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Related Disease Score Top Affiliating Genes
1 histiocytoma 10.8
2 fibrous histiocytoma 10.8
3 spleen cancer 10.7 DES MYOD1
4 omphalocele 10.7 DES MYOD1
5 testis rhabdomyosarcoma 10.7 DES MYOD1
6 mucinous ovarian cystadenoma 10.7 DES MYOD1
7 rnase t2-deficient leukoencephalopathy 10.6 CDK4 MDM2
8 immunodeficiency, centromere instability and facial anomalies syndrome 10.6 DES MYOD1
9 cardiac tamponade 10.6 DES MYOD1
10 epidural neoplasm 10.6 CDK4 MDM2
11 reactive arthritis 10.6 CDK4 MDM2
12 coronary aneurysm 10.6 CDK4 MDM2
13 metachronous osteosarcoma of the bone 10.6 CDK4 MDM2
14 lipoic acid biosynthesis defects 10.6 CDK4 MDM2
15 spindle cell liposarcoma 10.5 DES MDM2
16 median neuropathy 10.5 CDK4 MDM2
17 malignant hyperthermia susceptibility type 3 10.5 DES HRAS
18 endodermal sinus tumor 10.5 MDM2 MYOD1
19 ovary rhabdomyosarcoma 10.5 DES HRAS
20 coronary restenosis 10.5 DES MDM2
21 juxtacortical chondrosarcoma 10.5 CDK4 MDM2
22 cholelithiasis 10.5 CDK4 MDM2
23 transitional cell carcinoma 10.4 DES MDM2 MYOD1
24 lateral medullary syndrome 10.4 HRAS MYOD1
25 primary pulmonary lymphoma 10.4 CDK4 MDM2 MYOD1
26 cutaneous liposarcoma 10.4 CDK4 MDM2 MYOD1
27 mucinous intrahepatic cholangiocarcinoma 10.4 CDK4 MDM2
28 skin lipoma 10.4 CDK4 DES MDM2
29 neurofibroma of the esophagus 10.4 CDK4 DES MDM2
30 secondary pulmonary hemosiderosis 10.4 CDK4 DES MDM2
31 sarcosinemia 10.4 CDK4 DES MDM2
32 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 10.4 DES MDM2
33 spindle cell sarcoma 10.4 CDK4 MDM2 MYOD1
34 kidney lipoma 10.3 CDK4 MDM2
35 adenosarcoma 10.3 CDK4 DES MDM2
36 accessory nerve disease 10.3 CDK4 DES MDM2
37 colon leiomyosarcoma 10.3 CALD1 MYOD1
38 small cell osteogenic sarcoma 10.3 CDK4 FOS MDM2
39 conventional central osteosarcoma 10.3 CDK4 FOS MDM2
40 ischemia 10.3 DES HRAS MYOD1
41 brain stem infarction 10.2 CALD1 MDM2
42 melanotic medulloblastoma 10.2 DES MYC MYOD1
43 alopecia areata 1 10.2 MYC PTER
44 sublingual gland adenoid cystic carcinoma 10.2 CALD1 HRAS
45 nephrogenic adenoma of urinary bladder 10.1 CALD1 DES
46 granular cell leiomyosarcoma 10.1 CALD1 DES MYOD1
47 ossifying fibromyxoid tumor 10.1 CDK4 HRAS
48 unilateral retinoblastoma 10.1 CDK4 MDM2 MYC
49 pharynx cancer 10.1 CDK4 MDM2 MYC
50 post-surgical hypoinsulinemia 10.1 CDK4 MDM2 MYC

Graphical network of the top 20 diseases related to Malignant Fibrous Histiocytoma of Bone:



Diseases related to Malignant Fibrous Histiocytoma of Bone

Symptoms & Phenotypes for Malignant Fibrous Histiocytoma of Bone

MGI Mouse Phenotypes related to Malignant Fibrous Histiocytoma of Bone:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 TAGLN CDK4 DES HRAS MDM2 MYC
2 muscle MP:0005369 9.63 CDK4 DES MDM2 MYC MYOD1 TAGLN
3 neoplasm MP:0002006 9.5 CDK4 FOS HRAS MDM2 MYC MYOD1
4 normal MP:0002873 9.17 CDK4 FOS HRAS MDM2 MYC MYOD1

Drugs & Therapeutics for Malignant Fibrous Histiocytoma of Bone

Drugs for Malignant Fibrous Histiocytoma of Bone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
4
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
6
Dactinomycin Approved Phase 3 50-76-0 2019 457193
7
Epirubicin Approved Phase 3 56420-45-2 41867
8
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
9
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
10
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
11 Alkylating Agents Phase 3,Phase 2
12 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
13 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
14 Isophosphamide mustard Phase 3,Phase 2
15 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
16 Anti-Infective Agents Phase 3,Phase 2
17 Antimitotic Agents Phase 3
18 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
19 Antirheumatic Agents Phase 3,Phase 2,Phase 1
20 Etoposide phosphate Phase 3,Phase 2
21 Immunosuppressive Agents Phase 3,Phase 2
22 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
23
Indinavir Approved Phase 2 150378-17-9 5362440
24
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
25
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
26
Bevacizumab Approved, Investigational Phase 2 216974-75-3
27
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
28
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
30
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
31 Anti-HIV Agents Phase 2
32 Anti-Retroviral Agents Phase 2
33 Antiviral Agents Phase 2
34 Cytochrome P-450 CYP3A Inhibitors Phase 2
35 Cytochrome P-450 Enzyme Inhibitors Phase 2
36 HIV Protease Inhibitors Phase 2
37 Liver Extracts Phase 2,Phase 1
38
protease inhibitors Phase 2
39 Imatinib Mesylate Phase 2 123596
40 Protein Kinase Inhibitors Phase 2
41 Angiogenesis Inhibitors Phase 2
42 Angiogenesis Modulating Agents Phase 2
43 Antibodies Phase 2,Phase 1
44 Antibodies, Monoclonal Phase 2,Phase 1
45 Immunoglobulins Phase 2,Phase 1
46 Antimetabolites Phase 2
47 Antimetabolites, Antineoplastic Phase 2
48 Dermatologic Agents Phase 2
49 Endothelial Growth Factors Phase 2
50 Folic Acid Antagonists Phase 2

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
4 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
5 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
6 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
7 Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
8 A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma Active, not recruiting NCT00667342 Phase 2 Cisplatin;Doxorubicin;Methotrexate;Ifosfamide;etoposide
9 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
10 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
11 Vaccine Therapy in Treating Patients With Metastatic Cancer Completed NCT00020267 Phase 1 interleukin-2;MAGE-12 peptide vaccine;Montanide ISA-51
12 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
13 Genetic Study of Patients and Families With Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma of the Bone Completed NCT00007046
14 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 glutamine

Search NIH Clinical Center for Malignant Fibrous Histiocytoma of Bone

Genetic Tests for Malignant Fibrous Histiocytoma of Bone

Anatomical Context for Malignant Fibrous Histiocytoma of Bone

MalaCards organs/tissues related to Malignant Fibrous Histiocytoma of Bone:

39
Bone, Lung, Liver, Endothelial, Brain, Smooth Muscle

Publications for Malignant Fibrous Histiocytoma of Bone

Articles related to Malignant Fibrous Histiocytoma of Bone:

(show top 50) (show all 82)
id Title Authors Year
1
Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features. ( 22588017 )
2011
2
Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone. ( 19936744 )
2010
3
Scalp metastasis from malignant fibrous histiocytoma of bone. ( 19119134 )
2008
4
Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry. ( 16630715 )
2006
5
Malignant fibrous histiocytoma of bone associated with type-1 neurofibromatosis. A case report. ( 15687166 )
2005
6
CASE REPORTS: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. ( 16205169 )
2005
7
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. ( 15540465 )
2004
8
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Patient Version ( 26389380 )
2002
9
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Health Professional Version ( 27054239 )
2002
10
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Patient Version ( 26539616 )
2002
11
Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone. ( 12401825 )
2002
12
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Health Professional Version ( 27559573 )
2002
13
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Patient Version ( 27077200 )
2002
14
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Patient Version ( 27559594 )
2002
15
Establishment and characterization of a cell line from a malignant fibrous histiocytoma of bone developing in a patient with multiple fibrous dysplasia. ( 11862471 )
2002
16
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. ( 12181274 )
2002
17
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Health Professional Version ( 26389179 )
2002
18
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Health Professional Version ( 26447276 )
2002
19
Primary fibrosarcoma and malignant fibrous histiocytoma of bone--a comparative ultrastructural study: evidence of a spectrum of fibroblastic differentiation. ( 10808553 )
2000
20
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. ( 10642003 )
2000
21
Cerebral metastases from malignant fibrous histiocytoma of bone. ( 18521291 )
2000
22
Neoadjuvant chemotherapy with doxorubicin and cisplatin in malignant fibrous histiocytoma of bone: A European Osteosarcoma Intergroup study. ( 10506628 )
1999
23
Malignant fibrous histiocytoma of bone: a retrospective EMSOS study of 125 cases. European Musculo-Skeletal Oncology Society. ( 10569265 )
1999
24
Malignant fibrous histiocytoma of bone: a clinicopathologic study of 81 patients. ( 9486593 )
1998
25
Neoadjuvant chemotherapy for high grade malignant fibrous histiocytoma of bone. ( 9577426 )
1998
26
Malignant fibrous histiocytoma of bone: conventional X-ray and MR imaging features. ( 9840391 )
1998
27
Neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone and in osteosarcoma located in the extremities: analogies and differences between the two tumors. ( 9426330 )
1997
28
Malignant fibrous histiocytoma of bone. A clinicopathologic study of 81 patients. ( 9028358 )
1997
29
Malignant fibrous histiocytoma of bone - Review of thirteen cases. ( 21594458 )
1996
30
Neoadjuvant chemotherapy for malignant fibrous histiocytoma of bone and for osteosarcoma of the limbs: a comparison between the results obtained for 21 and 144 patients, respectively, treated during the same period with the same chemotherapy protocol. ( 8968117 )
1996
31
The value of high-dose methotrexate-based neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone. ( 8636762 )
1996
32
Osteosarcoma versus malignant fibrous histiocytoma of bone in patients older than 40 years. A clinicopathologic and immunohistochemical analysis with special reference to malignant fibrous histiocytoma-like osteosarcoma. ( 8625223 )
1995
33
Multiple malignant fibrous histiocytoma of bone. A case report. ( 8197860 )
1994
34
Malignant fibrous histiocytoma of bone following primitive neuroectodermal tumor of bone. ( 8127258 )
1994
35
Tumor progression in a giant cell type malignant fibrous histiocytoma of bone: clinical, radiologic, histologic, and cytogenetic evidence. ( 7519876 )
1994
36
Prognostic factors of malignant fibrous histiocytoma of bone. A clinical and histopathologic analysis of 34 cases. ( 8364866 )
1993
37
Malignant fibrous histiocytoma of bone: the experience of the New South Wales Bone Tumour Registry. ( 8386925 )
1993
38
Chemotherapy of malignant fibrous histiocytoma of bone. ( 8394734 )
1993
39
Chromosome abnormalities in malignant fibrous histiocytoma of bone. ( 1664081 )
1991
40
Malignant fibrous histiocytoma of bone. ( 2164619 )
1990
41
Multiple and familial malignant fibrous histiocytoma of bone. A report of two cases. ( 2154500 )
1990
42
Primary chemotherapy and delayed surgery for malignant fibrous histiocytoma of bone in the extremity. ( 2178284 )
1990
43
Cytogenetic findings in a primary malignant fibrous histiocytoma of bone and the lung metastasis. ( 2163505 )
1990
44
Intra-arterial cisplatinum and intravenous adriamycin in the treatment of osteosarcoma and malignant fibrous histiocytoma of bone: early surgical and clinical results. ( 2174327 )
1990
45
Malignant fibrous histiocytoma of bone. ( 2536999 )
1989
46
Malignant fibrous histiocytoma of bone: initial diagnosis by aspiration biopsy cytology. ( 2855512 )
1988
47
Malignant fibrous histiocytoma of bone. ( 3006959 )
1986
48
Chemotherapy-induced complete remission of a malignant fibrous histiocytoma of bone. An 11-year follow-up. ( 3008679 )
1986
49
Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients. ( 3006524 )
1986
50
Radiologic case study. Malignant fibrous histiocytoma of bone. ( 3014461 )
1986

Variations for Malignant Fibrous Histiocytoma of Bone

Expression for Malignant Fibrous Histiocytoma of Bone

Search GEO for disease gene expression data for Malignant Fibrous Histiocytoma of Bone.

Pathways for Malignant Fibrous Histiocytoma of Bone

Pathways related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 FOS HRAS MDM2 MYC
2
Show member pathways
12.38 CDK4 FOS HRAS MDM2 MYC
3 12.32 CDK4 FOS HRAS MDM2 MYC
4
Show member pathways
12.31 FOS HRAS MDM2 MYC
5 12.23 CDK4 FOS HRAS MYC
6
Show member pathways
12.18 FOS HRAS MDM2 MYC
7 12.16 HRAS MDM2 MYC
8 12.16 CDK4 HRAS MDM2
9
Show member pathways
12.12 CDK4 FOS MDM2
10
Show member pathways
12.08 CDK4 FOS MYC
11
Show member pathways
12.07 FOS HRAS MDM2 MYC
12
Show member pathways
12.06 CDK4 HRAS MDM2 MYC
13 12 CDK4 MDM2 MYC
14
Show member pathways
11.99 FOS HRAS MYC
15
Show member pathways
11.92 FOS HRAS MYC
16 11.86 CDK4 FOS MYC
17 11.83 HRAS MDM2 MYC
18 11.82 HRAS MDM2 MYC
19
Show member pathways
11.81 FOS HRAS MYC
20 11.74 FOS MYC MYOD1
21 11.73 BGLAP DES MYOD1
22 11.68 CDK4 MDM2 MYC
23 11.63 BGLAP FOS MDM2
24 11.6 CDK4 HRAS MDM2 MYC
25
Show member pathways
11.46 FOS HRAS MYC
26 11.4 BGLAP MDM2 MYOD1
27 11.34 CDK4 FOS MYC MYOD1
28 11.27 CDK4 MDM2 MYC
29 11.22 HRAS MYC
30 11.22 CDK4 MDM2 MYC
31 11.2 FOS HRAS
32 11.19 CDK4 MDM2
33
Show member pathways
11.15 FOS HRAS
34 11.12 CDK4 HRAS MDM2 MYC
35 11.11 FOS MYC
36 11.11 CDK4 FOS MYC
37 11.08 CDK4 MYC
38 11.01 FOS HRAS
39 10.99 MDM2 MYC
40
Show member pathways
10.98 MDM2 MYC
41 10.88 FOS HRAS
42 10.76 CDK4 FOS HRAS MYC

GO Terms for Malignant Fibrous Histiocytoma of Bone

Cellular components related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor complex GO:0005667 8.8 CDK4 FOS MYOD1

Biological processes related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.71 CDK4 HRAS MDM2 MYC
2 cell aging GO:0007569 9.43 BGLAP HRAS
3 response to toxic substance GO:0009636 9.43 CDK4 FOS MDM2
4 cellular response to gamma radiation GO:0071480 9.37 HRAS MDM2
5 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
6 regulation of gene expression GO:0010468 9.26 CDK4 MDM2 MYC MYOD1
7 response to gravity GO:0009629 9.16 BGLAP FOS
8 response to drug GO:0042493 9.02 BGLAP CDK4 FOS MDM2 MYC

Sources for Malignant Fibrous Histiocytoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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