MCID: MLG088
MIFTS: 39

Malignant Germ Cell Tumor

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Malignant Germ Cell Tumor

MalaCards integrated aliases for Malignant Germ Cell Tumor:

Name: Malignant Germ Cell Tumor 49
Malignant Germ Cell Neoplasm 69
Germ Cell Cancer 69

Classifications:



External Ids:

Summaries for Malignant Germ Cell Tumor

MalaCards based summary : Malignant Germ Cell Tumor, also known as malignant germ cell neoplasm, is related to testicular malignant germ cell cancer and testicular germ cell cancer. An important gene associated with Malignant Germ Cell Tumor is LDHA (Lactate Dehydrogenase A), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Vinblastine and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include brain, ovary and testis, and related phenotype is reproductive system.

Related Diseases for Malignant Germ Cell Tumor

Diseases in the Germ Cells Tumors family:

Malignant Germ Cell Tumor

Diseases related to Malignant Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 testicular malignant germ cell cancer 32.0 AFP ALPP
2 testicular germ cell cancer 31.2 ALPP AR ESR2
3 testicular cancer 30.6 AFP ALPP AR CGA CGB5
4 cryptorchidism, unilateral or bilateral 28.7 ALPPL2 AR CGA CGB5
5 choriocarcinoma 28.7 ALPP ALPPL2 CGA CGB5
6 malignant germ cell tumor of the cervix uteri 12.2
7 malignant germ cell tumor of the vagina 12.1
8 malignant germ cell tumor of the corpus uteri 12.1
9 malignant cardiac germ cell tumor 11.1
10 germ cells tumors 10.7
11 nonseminomatous germ cell tumor 10.3 AFP CGB5
12 malignant sertoli cell tumor 10.3 AFP CGB5
13 corpus luteum cyst 10.3 AFP CGB5
14 extragonadal germ cell cancer 10.3 AFP CGB5
15 ovarian mixed germ cell neoplasm 10.3 AFP CGA
16 polyembryoma 10.3 AFP CGA
17 anorchia 10.3 CGA CGB5
18 sacrococcygeal teratoma 10.3 AFP CGA
19 mixed germ cell tumor 10.3 AFP CGA
20 ovarian endodermal sinus tumor 10.3 AFP KPNA2
21 triploidy 10.3 AFP CGA
22 chromosomal triplication 10.2 AFP CGA
23 orofaciodigital syndrome viii 10.2 AFP CGA
24 ovarian primitive germ cell tumor 10.2 AFP KPNA2
25 hydatidiform mole, recurrent, 1 10.2 CGA CGB5
26 hydrocele 10.2 AFP CGA
27 endodermal sinus tumor 10.1 AFP ALPP
28 dysgerminoma of ovary 10.1 AFP ALPP
29 alpha-fetoprotein deficiency 10.0
30 penis agenesis 10.0 AR CGA
31 teratoma 10.0
32 postmenopausal atrophic vaginitis 10.0 AR ESR2
33 transsexualism 10.0 AR ESR2
34 gender identity disorder 10.0 AR ESR2
35 ectopic pregnancy 10.0 CGA CGB5
36 vaginitis 9.9 AR ESR2
37 serous cystadenocarcinoma 9.9 ALPP ESR2
38 androgen insensitivity syndrome 9.9 AR CGA
39 gonadoblastoma 9.9
40 mediastinitis 9.9
41 prostatic hypertrophy 9.9 ALPP AR
42 gynecomastia 9.8 AR CGA
43 testicular germ cell tumor 9.8 AFP AR ESR2
44 sex differentiation disease 9.7
45 gestational choriocarcinoma 9.7
46 growing teratoma syndrome 9.7
47 mast cell disease 9.7
48 histiocytosis 9.7
49 46,xy sex reversal 1 9.7
50 cerebritis 9.7

Graphical network of the top 20 diseases related to Malignant Germ Cell Tumor:



Diseases related to Malignant Germ Cell Tumor

Symptoms & Phenotypes for Malignant Germ Cell Tumor

MGI Mouse Phenotypes related to Malignant Germ Cell Tumor:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.1 AFP ALPPL2 AR CGA ESR2 FGF4

Drugs & Therapeutics for Malignant Germ Cell Tumor

Drugs for Malignant Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 127)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vinblastine Approved Phase 3,Phase 2 865-21-4 241903 13342
2
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
3
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
4
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
5
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
6
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
7
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
8
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
9
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
10
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
11
Mesna Approved, Investigational Phase 3 3375-50-6 598
12
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
13
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
14
Diphenhydramine Approved, Investigational Phase 3 58-73-1, 147-24-0 3100
15
Promethazine Approved, Investigational Phase 3 60-87-7 4927
16
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
17
Cyproheptadine Approved Phase 3 129-03-3 2913
18 Castor oil Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3
19 Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
20 Alkylating Agents Phase 3,Phase 2,Phase 1
21 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
22 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
23 Etoposide phosphate Phase 3,Phase 2,Phase 1
24 Antimitotic Agents Phase 3,Phase 2,Phase 1
25 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
26 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
27 Testosterone undecanoate Phase 2, Phase 3
28
Testosterone enanthate Phase 2, Phase 3 315-37-7 9416
29 Cathartics Phase 2, Phase 3
30 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
31 Albumin-Bound Paclitaxel Phase 3,Phase 2
32 Gastrointestinal Agents Phase 2, Phase 3
33 Testosterone 17 beta-cypionate Phase 2, Phase 3
34 Anabolic Agents Phase 2, Phase 3
35 Androgens Phase 2, Phase 3
36 Hormone Antagonists Phase 2, Phase 3
37 Dermatologic Agents Phase 3,Phase 2
38 Hormones Phase 2, Phase 3
39 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
40 Laxatives Phase 2, Phase 3
41 Antineoplastic Agents, Hormonal Phase 2, Phase 3
42 Podophyllotoxin Phase 3 518-28-5
43 Dexamethasone acetate Phase 3 1177-87-3
44 Histamine H2 Antagonists Phase 3
45 Keratolytic Agents Phase 3
46 BB 1101 Phase 3
47
Histamine Phosphate Phase 3 51-74-1 65513
48
Serotonin Phase 3 50-67-9 5202
49 Serotonin Agents Phase 3
50 Serotonin Antagonists Phase 3

Interventional clinical trials:

(show all 45)

# Name Status NCT ID Phase Drugs
1 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
2 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
3 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
4 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
5 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
6 Combination Chemotherapy in Treating Young Patients With Recurrent or Resistant Malignant Germ Cell Tumors Completed NCT00467051 Phase 2 paclitaxel;carboplatin;ifosfamide
7 Combination Chemotherapy Plus Amifostine in Treating Children With Malignant Germ Cell Tumors Completed NCT00003811 Phase 2 amifostine trihydrate;cisplatin;etoposide
8 Combination Chemotherapy in Treating Children With Non-testicular Malignant Germ Cell Tumors Completed NCT00002489 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;etoposide;leucovorin calcium;methotrexate;vincristine sulfate
9 Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors Completed NCT00006450 Phase 2 Phenylbutyrate
10 Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or Leukemia Completed NCT01154816 Phase 2 Alisertib
11 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
12 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
13 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
14 Arsenic Trioxide in Treating Patients With Advanced Neuroblastoma or Other Childhood Solid Tumors Completed NCT00024258 Phase 2 arsenic trioxide
15 A Multicenter Study to Evaluate a Risk-adapted Strategy for Treatment of Extra Cranial Non Seminomateous Malignant Germ Cell Tumour in Children and Adolescent Recruiting NCT02104986 Phase 2 Velbe-Bleomycin-Cisplatin;Vepeside-ifosfamide-Cisplatin
16 Pediatric MATCH: Trk Inhibitor LOXO-101 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions Recruiting NCT03213704 Phase 2 Larotrectinib
17 Pediatric MATCH: PI3K/mTOR Inhibitor LY3023414 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With TSC or PI3K/MTOR Mutations Recruiting NCT03213678 Phase 2 PI3K/mTOR Inhibitor LY3023414
18 Pediatric MATCH: Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders Recruiting NCT03155620 Phase 2 Ensartinib;Erdafitinib;Larotrectinib;Olaparib;PI3K/mTOR Inhibitor LY3023414;Selumetinib Sulfate;Tazemetostat;Vemurafenib
19 Pediatric MATCH: Vemurafenib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With BRAF V600 Mutations Recruiting NCT03220035 Phase 2 Vemurafenib
20 Pediatric MATCH: Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations Recruiting NCT03213665 Phase 2 Tazemetostat
21 Pediatric MATCH: Olaparib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Defects in DNA Damage Repair Genes Recruiting NCT03233204 Phase 2 Olaparib
22 Pediatric MATCH: Erdafitinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With FGFR Mutations Recruiting NCT03210714 Phase 2 Erdafitinib
23 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Recruiting NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
24 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
25 Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors Unknown status NCT00007813 Phase 1 carboplatin;cyclophosphamide;etoposide
26 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
27 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
28 Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas Completed NCT00101270 Phase 1 irinotecan hydrochloride;oxaliplatin
29 Erlotinib and Temozolomide in Treating Young Patients With Recurrent or Refractory Solid Tumors Completed NCT00077454 Phase 1 erlotinib hydrochloride;temozolomide
30 Flavopiridol in Treating Children With Relapsed or Refractory Solid Tumors or Lymphomas Completed NCT00012181 Phase 1 alvocidib
31 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
32 Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors Completed NCT00303940 Phase 1 carboplatin;talabostat mesylate;temozolomide
33 ABT-751 in Treating Young Patients With Refractory Solid Tumors Completed NCT00036959 Phase 1 ABT-751
34 Ixabepilone in Treating Young Patients With Solid Tumors or Leukemia That Haven't Responded to Therapy Completed NCT00030108 Phase 1 ixabepilone
35 Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors Completed NCT00020150 Phase 1 O6-benzylguanine;temozolomide
36 Busulfan in Treating Children and Adolescents With Refractory CNS Cancer Completed NCT00006246 Phase 1 busulfan
37 Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors Terminated NCT00003926 Phase 1 amifostine trihydrate;busulfan;filgrastim;melphalan;thiotepa
38 Etoposide, Carboplatin, and Bleomycin in Treating Young Patients Undergoing Surgery For Malignant Germ Cell Tumors Unknown status NCT00276718 carboplatin;etoposide
39 Cancer and Hearing Loss Related in Children Unknown status NCT02425397
40 Studying Biomarkers in Samples From Younger Patients With Malignant Germ Cell Tumor Progression Completed NCT01433224
41 Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell Tumors Completed NCT00066482 cisplatin;cyclophosphamide;etoposide
42 Development of Strategies to Increase Enrollment in Clinical Trials for Children With Cancer Completed NCT00002485
43 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
44 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 busulfan;melphalan;topotecan hydrochloride
45 Differences in Trends Malignant Germ Cell Tumors in Males and Females: A SEER Population-based Study Withdrawn NCT00322790

Search NIH Clinical Center for Malignant Germ Cell Tumor

Genetic Tests for Malignant Germ Cell Tumor

Anatomical Context for Malignant Germ Cell Tumor

MalaCards organs/tissues related to Malignant Germ Cell Tumor:

38
Brain, Ovary, Testis, Testes, Liver, Lymph Node, Pineal

Publications for Malignant Germ Cell Tumor

Articles related to Malignant Germ Cell Tumor:

(show top 50) (show all 80)
# Title Authors Year
1
Novel loss of function mutation in KRIT1/CCM1 is associated with distinctly progressive cerebral and spinal cavernous malformations after radiochemotherapy for intracranial malignant germ cell tumor. ( 28488085 )
2017
2
Safety and efficacy of bleomycin/pingyangmycin-containing chemotherapy regimens for malignant germ cell tumor patients in the female genital system. ( 28160575 )
2017
3
Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. ( 26485622 )
2016
4
Swyer's Syndrome with Mixed Ovarian Malignant Germ Cell Tumor and Ovarian Gonadoblastoma. ( 27411466 )
2016
5
Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis. ( 25769700 )
2015
6
Metastatic Treated Malignant Germ Cell Tumors: Is SALL4 a Better Marker Than Placental Alkaline Phosphatase? ( 25906119 )
2015
7
Feto-maternal outcomes of pregnancy complicated by ovarian malignant germ cell tumor: a systematic review of literature. ( 25150953 )
2014
8
Neo-adjuvant chemotherapy in the treatment of advanced malignant germ cell tumors of ovary. ( 24145115 )
2014
9
Sacrococcygeal malignant germ cell tumor (SC-MGCT) with intraspinal extension. ( 24952799 )
2014
10
Impact of central surgical review in a study of malignant germ cell tumors. ( 25783295 )
2014
11
Two case reports of a malignant germ cell tumor of ovary and a granulosa cell tumor: interest of tumoral immunochemistry in the identification and management. ( 24982844 )
2014
12
Usefulness of OCT4/3 immunostain in pediatric malignant germ cell tumors. ( 22506928 )
2013
13
Brain metastases during follow-up of children and adolescents with extracranial malignant germ cell tumors: risk adapted management decision tree analysis based on data of the MAHO/MAKEI-registry. ( 22693072 )
2013
14
High-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for recurrent primary mediastinal malignant germ cell tumor: A case report. ( 24373121 )
2013
15
LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. ( 23774216 )
2013
16
Outcomes of combined modality therapy for patients with stage III or IV mediastinal malignant germ cell tumors. ( 23553421 )
2013
17
Utility of OCT3/4, TSPY and I^-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads. ( 23396295 )
2013
18
Is there a role for carboplatin in the treatment of malignant germ cell tumors? A systematic review of adult and pediatric trials. ( 22976789 )
2013
19
Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis. ( 22962582 )
2012
20
A rare case of solitary metastatic non-seminomatous malignant germ cell tumor to the prostate. ( 23040630 )
2012
21
Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary. ( 22448662 )
2012
22
Delayed Recognition of Disorders of Sex Development (DSD): A Missed Opportunity for Early Diagnosis of Malignant Germ Cell Tumors. ( 22315593 )
2012
23
Extracranial malignant germ cell tumors. ( 22706911 )
2012
24
CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubules. ( 22895825 )
2012
25
Therapy-associated secondary tumors in patients with non-germinomatous malignant germ cell tumors. ( 21533838 )
2011
26
Evaluation of neoadjuvant therapy in patients with nongerminomatous malignant germ cell tumors. ( 21456918 )
2011
27
Unusual liver locations of growing teratoma syndrome in ovarian malignant germ cell tumors. ( 24371596 )
2011
28
Identification of microRNAs From the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. ( 21173133 )
2011
29
Malignant germ cell tumors associated with Swyer syndrome. ( 21225934 )
2011
30
Family history of cancer and malignant germ cell tumors in children: a report from the Children's Oncology Group. ( 19842050 )
2010
31
Rete testis invasion by malignant germ cell tumor and/or intratubular germ cell neoplasia: what is the significance of this finding? ( 20573373 )
2010
32
Modified grading system for clinical outcome of intracranial non-germinomatous malignant germ cell tumors. ( 22966355 )
2010
33
Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. ( 20332240 )
2010
34
Proton beam therapy for loco-regional control of a recurrent mixed malignant germ cell tumor of the skull in a 22-month-old girl. ( 20514623 )
2010
35
Carbon 11-labeled methionine positron emission tomography for detection of residual viable tumor cells after adjuvant therapy in nongerminomatous malignant germ cell tumors in 2 cases including an autopsy case. ( 18262610 )
2009
36
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study. ( 19258947 )
2009
37
Survival after an antiangiogenetic therapy and surgery in a wide spread growing teratoma originating from a testicular mixed malignant germ cell tumor. ( 19437360 )
2009
38
False-positive serum human chorionic gonadotropin (HCG) in a male patient with a malignant germ cell tumor of the testis: a case report and review of the literature. ( 18984875 )
2008
39
Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. ( 18525461 )
2008
40
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. ( 18571705 )
2008
41
Comprehensive staging allows for excellent outcome in patients with localized malignant germ cell tumor of the ovary. ( 18948812 )
2008
42
Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence. ( 19115694 )
2008
43
Pediatric malignant germ cell tumors show characteristic transcriptome profiles. ( 18519683 )
2008
44
Chemotherapy for the treatment of children and adolescents with malignant germ cell tumors. ( 18612144 )
2008
45
Regression pattern of alpha fetoprotein level changed after treatment of malignant germ cell tumor. ( 18575279 )
2008
46
Viable malignant germ cell tumor in the postchemotherapy retroperitoneal lymph node dissection specimen: can it be predicted using clinical parameters? ( 16944534 )
2006
47
High lactate dehydrogenase isoenzyme 1 in a patient with malignant germ cell tumor is attributable to aberrant methylation of the LDHA gene. ( 15297388 )
2004
48
Management of primary malignant germ cell tumor of the mediastinum. ( 15342665 )
2004
49
Congenital mixed malignant germ cell tumor involving cerebrum and orbit. ( 12825484 )
2003
50
Re: organ sparing surgery for malignant germ cell tumor of the testis. ( 12187245 )
2002

Variations for Malignant Germ Cell Tumor

Expression for Malignant Germ Cell Tumor

Search GEO for disease gene expression data for Malignant Germ Cell Tumor.

Pathways for Malignant Germ Cell Tumor

Pathways related to Malignant Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.26 AFP ALPP FGF4
2 10.91 AR CGA
3
Show member pathways
10.62 ALPP ALPPL2
4 9.83 ALPP ALPPL2

GO Terms for Malignant Germ Cell Tumor

Cellular components related to Malignant Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 AFP ALPPL2 CGA CGB5 ESR2 FGF4

Biological processes related to Malignant Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.16 AR ESR2
2 cell-cell signaling GO:0007267 9.02 AR CGA CGB5 ESR2 FGF4
3 peptide hormone processing GO:0016486 8.96 CGA CGB5

Molecular functions related to Malignant Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.26 AR ESR2
2 nuclear receptor activity GO:0004879 9.16 AR ESR2
3 steroid binding GO:0005496 8.96 AR ESR2
4 alkaline phosphatase activity GO:0004035 8.62 ALPP ALPPL2

Sources for Malignant Germ Cell Tumor

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