MCID: MLG088
MIFTS: 35

Malignant Germ Cell Tumor malady

Cancer category

Summaries for Malignant Germ Cell Tumor

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33MalaCards
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MalaCards: Malignant Germ Cell Tumor is related to germ cell tumors and germ cell cancer. An important gene associated with Malignant Germ Cell Tumor is SALL4 (sal-like 4 (Drosophila)), and among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Oct4 in Mammalian ESC Pluripotency. The compounds glucose and oestriol have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, lymph node and brain, and related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Malignant Germ Cell Tumor

Sources:
43NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

malignant germ cell tumor 43


Related Diseases for Malignant Germ Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases in the germ cell tumors family:

malignant germ cell tumor

Diseases related to Malignant Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1germ cell tumors31.4KIT
2germ cell cancer30.5AFP
3germinoma30.5CGB5, AFP, POU5F1, KIT
4teratoma30.4SALL4, CGB5, AFP, POU5F1, GPC3, KIT
5extragonadal germ cell tumor30.2AFP, CGB5
6gonadoblastoma30.2KIT, POU5F1
7dysgerminoma30.2KIT, POU5F1, AFP, CGB5
8mixed germ cell tumor10.6
9ovarian germ cell tumor10.5
10ovarian germ cell malignant tumor10.5
11testicular germ cell tumor10.4
12malignant germ cell tumor of the cervix uteri10.4
13malignant germ cell tumor of the corpus uteri10.3
14malignant cardiac germ cell tumor10.2
15klinefelter's syndrome10.2
16malignant histiocytosis10.2
17urticaria pigmentosa10.2
18t-cell leukemia10.2
19testicular malignant germ cell cancer10.2
20urticaria10.2
21swyer syndrome10.2
22male germ cell tumor10.2
23growing teratoma syndrome10.2
24esophagitis10.0CDX2
25pancreatic cancer10.0CDX2
26leydig cell tumor10.0CGB5
27pituitary adenoma10.0POU5F1
28anencephaly10.0AFP
29myeloid leukemia10.0KIT
30sertoli-leydig cell tumor10.0AFP
31malignant mesothelioma10.0GPC3
32azoospermia10.0CGB5
33colorectal cancer10.0PROM1, CDX2
34sertoli cell tumor10.0ENO2
35lung cancer10.0ENO2
36thymic carcinoma10.0KIT
37embryonal cancer10.0POU5F1, AFP
38rhabdomyosarcoma10.0ENO2
39endodermal sinus tumor10.0AFP, CGB5
40dermatofibrosarcoma protuberans10.0KIT
41testicular cancer10.0AFP, CGB5
42anaplastic large cell lymphoma10.0ENO2
43hepatocellular adenoma10.0AFP, GPC3
44adenoma10.0CDX2, ENO2
45pheochromocytoma10.0ENO2, CDX2
46hepatitis10.0AFP, GPC3
47cholangiocarcinoma10.0GPC3, CDX2, AFP
48medulloblastoma10.0PROM1, ENO2
49ovarian cancer10.0CGB5, AFP, GPC3
50merkel cell carcinoma10.0KIT, ENO2

Graphical network of the top 20 diseases related to Malignant Germ Cell Tumor:



Diseases related to malignant germ cell tumor

Clinical Features for Malignant Germ Cell Tumor

Drugs & Therapeutics for Malignant Germ Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Malignant Germ Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Malignant Germ Cell Tumor

Search NIH Clinical Center for Malignant Germ Cell Tumor

Search CenterWatch for Malignant Germ Cell Tumor

Genetic Tests for Malignant Germ Cell Tumor

Anatomical Context for Malignant Germ Cell Tumor

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33MalaCards
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MalaCards organs/tissues related to Malignant Germ Cell Tumor:

33
Bone marrow, Lymph node, Brain, Liver, Lung, Ovary, Prostate, Testis, Pancreatic islet, Pineal, Pituitary, Testis germ

Animal Models for Malignant Germ Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Malignant Germ Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.5TCL1A, CDX2, AFP
2MP:00020068.8PROM1, AFP, CDX2, KIT, LDHA
3MP:00053818.5SALL4, POU5F1, CDX2, GPC3, KIT
4MP:00053858.3LDHA, KIT, GPC3, CDX2, PROM1, SALL4
5MP:00107687.7SALL4, PROM1, AFP, POU5F1, CDX2, GPC3
6MP:00053847.5SALL4, PROM1, POU5F1, CDX2, GPC3, KIT

Publications for Malignant Germ Cell Tumor

Sources:
51PubMed
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Articles related to Malignant Germ Cell Tumor:

(show top 50)    (show all 148)
idTitleAuthorsYear
1
Incidence of malignant ovarian germ cell tumors (MOGCTs) in Saudi Arabia. (24412326)
2014
2
Phytoestrogens regulate the proliferation and expression of stem cell factors in cell lines of malignant testicular germ cell tumors. (23969837)
2013
3
Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis. (23575763)
2013
4
Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stage I non-seminomatous germ cell tumor with malignant transformation. (23072289)
2013
5
Malignant sacrococcygeal germ cell tumors in children: a 30-year experience from a single institution. (23549000)
2013
6
The significance of comprehensive staging surgery in malignant ovarian germ cell tumors. (24007946)
2013
7
Growing teratoma syndrome in intracranial non-germinomatous germ cell tumors (iNGGCTs): a risk for secondary malignant transformation-a report of two cases. (24122016)
2013
8
High-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for recurrent primary mediastinal malignant germ cell tumor: A case report. (24373121)
2013
9
Utility of OCT3/4, TSPY and I^-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads. (23396295)
2013
10
Incidence patterns and trends of malignant gonadal and extragonadal germ cell tumors in Germany, 1998-2008. (23683844)
2013
11
Is there a role for carboplatin in the treatment of malignant germ cell tumors? A systematic review of adult and pediatric trials. (22976789)
2013
12
Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis. (22962582)
2012
13
Delayed Recognition of Disorders of Sex Development (DSD): A Missed Opportunity for Early Diagnosis of Malignant Germ Cell Tumors. (22315593)
2012
14
Effects of N-acetyl-L-cysteine on bleomycin induced oxidative stress in malignant testicular germ cell tumors. (22940535)
2012
15
Extracranial malignant germ cell tumors. (22706911)
2012
16
The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (23011538)
2012
17
Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary. (22448662)
2012
18
Teratoma with somatic-type malignant components in germ cell tumors of the testis: a clinicopathologic analysis of 40 cases with outcome correlation. (21134986)
2011
19
Prognostic impact of laterality in malignant ovarian germ cell tumors. (21475076)
2011
20
Unusual liver locations of growing teratoma syndrome in ovarian malignant germ cell tumors. (24371596)
2011
21
Germinoma with malignant transformation to nongerminomatous germ cell tumor. (20809716)
2010
22
Proton beam therapy for loco-regional control of a recurrent mixed malignant germ cell tumor of the skull in a 22-month-old girl. (20514623)
2010
23
Malignant ovarian germ cell tumors: clinico-pathological presentation and survival outcomes. (19961281)
2010
24
Rete testis invasion by malignant germ cell tumor and/or intratubular germ cell neoplasia: what is the significance of this finding? (20573373)
2010
25
Malignant ovarian germ cell tumors: a single-institution experience. (19307952)
2009
26
Carbon 11-labeled methionine positron emission tomography for detection of residual viable tumor cells after adjuvant therapy in nongerminomatous malignant germ cell tumors in 2 cases including an autopsy case. (18262610)
2009
27
Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries. (18287340)
2008
28
Chemotherapy for the treatment of children and adolescents with malignant germ cell tumors. (18612144)
2008
29
Tissue AP-2gamma and Oct-3/4, and serum CA 125 as diagnostic and prognostic markers of malignant ovarian germ cell tumors. (18497549)
2008
30
Regression pattern of alpha fetoprotein level changed after treatment of malignant germ cell tumor. (18575279)
2008
31
Viable malignant germ cell tumor in the postchemotherapy retroperitoneal lymph node dissection specimen: can it be predicted using clinical parameters? (16944534)
2006
32
True malignant histiocytosis with trisomy 9 following primary mediastinal germ cell tumor. (16809892)
2006
33
Congenital mixed malignant germ cell tumor involving cerebrum and orbit. (12825484)
2003
34
Re: organ sparing surgery for malignant germ cell tumor of the testis. (12187245)
2002
35
Levels of beta-human chorionic gonadotropin in cerebrospinal fluid of patients with malignant germ cell tumor can be used to detect early recurrence and monitor the response to treatment. (11007160)
2000
36
Expression and prognostic significance of proliferating cell nuclear antigen and Ki-67 in malignant ovarian germ cell tumors. (10533299)
1999
37
Neuroradiology case of the day. Malignant mixed germ cell tumor with yolk sac and teratomatous components. (10336209)
1999
38
Mixed malignant germ cell tumor of the fallopian tube. (10202679)
1999
39
Systemic mast cell disease associated with primary ovarian mixed malignant germ cell tumor. (9865846)
1998
40
Cytogenetics of a malignant ovarian germ-cell tumor. (9650555)
1998
41
Successful treatment with combined chemotherapy (carboplatin, etoposide, adriamycin, bleomycin) and radiotherapy for recurrent intracranial malignant germ cell tumor: case report]. (7541899)
1995
42
Non-germ-cell or teratomatous malignant tumors showing additional rhabdomyoblastic differentiation, with emphasis on the malignant Triton tumor. (8202648)
1994
43
Radiological case of the month. Malignant ovarian germ cell tumor. (8395763)
1993
44
Malignant testicular germ cell tumor in father and son: a case report. (2545021)
1989
45
CT and MR imaging of malignant germ cell tumor of the undescended testis. (2569246)
1989
46
Malignant mixed germ cell tumor of the ovary in a young woman with Smith-Lemli-Opitz syndrome. (2542142)
1989
47
A malignant mixed germ cell tumor originating from the pituitary gland with a suprasellar extension: a case report. (2856468)
1986
48
Malignant germ cell tumor of the anterior mediastinum with leukemia-like infiltration. (2418628)
1985
49
Case 50-1980: mixed malignant germ-cell tumor. (6259530)
1981
50
Prognostic factors in malignant germ cell tumors of the ovary in children excluding pure dysgerminoma. (689058)
1978

Genetic Variations for Malignant Germ Cell Tumor

Expression for genes affiliated with Malignant Germ Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Germ Cell Tumor

Search GEO for disease gene expression data for Malignant Germ Cell Tumor.

Pathways for genes affiliated with Malignant Germ Cell Tumor

Sources:
52QIAGEN, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CDX2, POU5F1
29.9CDX2, POU5F1
39.6AFP, POU5F1, CDX2
49.4TCL1A, CDX2, POU5F1

Compounds for genes affiliated with Malignant Germ Cell Tumor

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience
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Compounds related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1glucose4510.1CGB5
2oestriol459.9AFP, CGB5
3clomiphene citrate459.7AFP, CGB5
4toluidine459.6ENO2, KIT
5vincristine45 50 1111.5CGB5, AFP, KIT
6steroid459.3CDX2, AFP, CGB5
7diethylstilbestrol45 29 1111.1ENO2, AFP, CGB5
8oligonucleotide459.0AFP, CDX2, GPC3, KIT
9spec-t459.0AFP, ENO2
10thymidine45 249.9AFP, CDX2, KIT, ENO2
11dmso458.9CGB5, AFP, ENO2
12methotrexate45 50 1110.7CGB5, AFP, KIT, ENO2
13ribonucleic acid458.7ENO2, KIT, CGB5
14glycogen45 249.6ENO2, KIT, AFP, CGB5
15etoposide45 50 60 1111.6ENO2, AFP, CGB5
16testosterone45 60 11 2411.4CGB5, AFP, KIT, ENO2
17paraffin458.4CGB5, AFP, CDX2, KIT, ENO2
18progesterone45 60 29 11 2412.4CGB5, AFP, CDX2, KIT, ENO2
19retinoic acid45 249.3CGB5, AFP, POU5F1, KIT, ENO2
20oxygen45 249.3CGB5, AFP, POU5F1, ENO2, LDHA
21lactate458.3CGB5, AFP, KIT, ENO2, LDHA
22lipid458.1CGB5, PROM1, AFP, GPC3, ENO2
23vegf458.0LDHA, ENO2, KIT, POU5F1, AFP, CGB5
24tyrosine457.9CGB5, AFP, CDX2, KIT, ENO2, LDHA

GO Terms for genes affiliated with Malignant Germ Cell Tumor

Sources:
16Gene Ontology
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Biological processes related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatic stem cell maintenanceGO:0350199.9CDX2, POU5F1
2stem cell maintenanceGO:0198279.0TCL1A, KIT, SALL4

Products for genes affiliated with Malignant Germ Cell Tumor

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Sources for Malignant Germ Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet