MCID: MLG088
MIFTS: 39

Malignant Germ Cell Tumor malady

Genetic diseases, Rare diseases, Cancer diseases categories

Summaries for Malignant Germ Cell Tumor

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34MalaCards
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MalaCards: Malignant Germ Cell Tumor is related to germ cell tumors and gonadoblastoma. An important gene associated with Malignant Germ Cell Tumor is SALL4 (spalt-like transcription factor 4), and among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Oct4 in Mammalian ESC Pluripotency. The compounds oestriol and clomiphene citrate have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and lymph node, and related mouse phenotypes are pigmentation and limbs/digits/tail.

Aliases & Classifications for Malignant Germ Cell Tumor

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44NIH Rare Diseases
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases


Aliases & Descriptions:

malignant germ cell tumor 44


Related Diseases for Malignant Germ Cell Tumor

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18GeneCards, 19GeneDecks
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Diseases in the Germ Cell Tumors family:

malignant germ cell tumor

Diseases related to Malignant Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 42)
idRelated DiseaseScoreTop Affiliating Genes
1germ cell tumors31.8KIT
2gonadoblastoma30.4POU5F1, KIT
3teratoma30.3CGB5, KIT, SALL4, POU5F1, AFP, GPC3
4choriocarcinoma30.3GPC3, CGB5, AFP
5dysgerminoma30.2CGB5, KIT, AFP, POU5F1
6hepatitis30.2AFP, GPC3
7leukemia30.2PROM1, CDX2, KIT, TCL1A
8malignant germ cell tumor of ovary10.5
9malignant germ cell tumor of the cervix uteri10.4
10mediastinitis10.4
11malignant germ cell tumor of the corpus uteri10.4
12langerhans-cell histiocytosis10.2
13neuronitis10.2
14cryptorchidism10.2
15urticaria pigmentosa10.2
16malignant cardiac germ cell tumor10.2
17gestational choriocarcinoma10.2
18histiocytosis10.2
19prostatitis10.2
20testicular malignant germ cell cancer10.2
21urticaria10.2
22swyer syndrome10.2
23growing teratoma syndrome10.2
24anencephaly10.1AFP
25leydig cell tumor10.1CGB5
26extragonadal germ cell tumor10.1AFP, CGB5
27tubular adenocarcinoma10.1CDX2, AFP
28endodermal sinus tumor10.1AFP, CGB5
29malignant mixed mullerian tumor10.0AFP, KIT
30embryonal cancer10.0AFP, POU5F1
31neural tube defects10.0CGB5, AFP
32testicular cancer10.0AFP, CGB5
33neuroendocrine carcinoma10.0CDX2, KIT
34hepatocellular adenoma10.0GPC3, AFP
35pre-eclampsia10.0AFP, CGB5, LDHA
36cholangiocarcinoma10.0GPC3, CDX2, AFP
37hepatoblastoma10.0GPC3, AFP
38stomach cancer10.0GPC3, CDX2, AFP
39germinoma10.0POU5F1, KIT, CGB5, AFP
40hepatocellular carcinoma9.9CDX2, GPC3, PROM1, AFP
41breast cancer9.9KIT, CDX2, LDHA, GPC3, POU5F1
42seminoma9.8POU5F1, TCL1A, KIT, CGB5, AFP, GPC3

Graphical network of the top 20 diseases related to Malignant Germ Cell Tumor:



Diseases related to malignant germ cell tumor

Symptoms for Malignant Germ Cell Tumor

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Drugs & Therapeutics for Malignant Germ Cell Tumor

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Germ Cell Tumor

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Anatomical Context for Malignant Germ Cell Tumor

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34MalaCards
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MalaCards organs/tissues related to Malignant Germ Cell Tumor:

34
Ovary, Testis, Lymph node, Bone marrow, Testes, Prostate, Lung, Liver, Brain, Bone, Pineal

Animal Models for Malignant Germ Cell Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Malignant Germ Cell Tumor:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.1KIT, PROM1, GPC3
2MP:00053718.9SALL4, GPC3, KIT, CDX2
3MP:00020068.8CDX2, KIT, LDHA, PROM1, AFP
4MP:00053818.7POU5F1, SALL4, KIT, CDX2, GPC3
5MP:00053808.7POU5F1, SALL4, KIT, CDX2, GPC3
6MP:00028738.4POU5F1, LDHA, KIT, CDX2, PROM1
7MP:00053858.3GPC3, SALL4, PROM1, LDHA, KIT, CDX2
8MP:00053848.2POU5F1, CDX2, KIT, PROM1, GPC3, SALL4
9MP:00053787.9SALL4, PROM1, CDX2, KIT, LDHA, GPC3
10MP:00053897.8CDX2, GPC3, AFP, POU5F1, SALL4, TCL1A
11MP:00107687.7GPC3, AFP, POU5F1, SALL4, PROM1, LDHA

Publications for Malignant Germ Cell Tumor

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53PubMed
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Articles related to Malignant Germ Cell Tumor:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Usefulness of OCT4/3 immunostain in pediatric malignant germ cell tumors. (22506928)
2013
2
Brain metastases during follow-up of children and adolescents with extracranial malignant germ cell tumors: risk adapted management decision tree analysis based on data of the MAHO/MAKEI-registry. (22693072)
2013
3
High-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for recurrent primary mediastinal malignant germ cell tumor: A case report. (24373121)
2013
4
Utility of OCT3/4, TSPY and I^-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads. (23396295)
2013
5
LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. (23774216)
2013
6
Is there a role for carboplatin in the treatment of malignant germ cell tumors? A systematic review of adult and pediatric trials. (22976789)
2013
7
Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis. (22962582)
2012
8
Delayed Recognition of Disorders of Sex Development (DSD): A Missed Opportunity for Early Diagnosis of Malignant Germ Cell Tumors. (22315593)
2012
9
A rare case of solitary metastatic non-seminomatous malignant germ cell tumor to the prostate. (23040630)
2012
10
Extracranial malignant germ cell tumors. (22706911)
2012
11
CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubules. (22895825)
2012
12
Identification of microRNAs From the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. (21173133)
2011
13
Therapy-associated secondary tumors in patients with non-germinomatous malignant germ cell tumors. (21533838)
2011
14
Proton beam therapy for loco-regional control of a recurrent mixed malignant germ cell tumor of the skull in a 22-month-old girl. (20514623)
2010
15
Family history of cancer and malignant germ cell tumors in children: a report from the Children's Oncology Group. (19842050)
2010
16
Modified grading system for clinical outcome of intracranial non-germinomatous malignant germ cell tumors. (22966355)
2010
17
Rete testis invasion by malignant germ cell tumor and/or intratubular germ cell neoplasia: what is the significance of this finding? (20573373)
2010
18
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study. (19258947)
2009
19
Survival after an antiangiogenetic therapy and surgery in a wide spread growing teratoma originating from a testicular mixed malignant germ cell tumor. (19437360)
2009
20
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (18571705)
2008
21
Pediatric malignant germ cell tumors show characteristic transcriptome profiles. (18519683)
2008
22
Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. (18525461)
2008
23
Chemotherapy for the treatment of children and adolescents with malignant germ cell tumors. (18612144)
2008
24
Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence. (19115694)
2008
25
Viable malignant germ cell tumor in the postchemotherapy retroperitoneal lymph node dissection specimen: can it be predicted using clinical parameters? (16944534)
2006
26
High lactate dehydrogenase isoenzyme 1 in a patient with malignant germ cell tumor is attributable to aberrant methylation of the LDHA gene. (15297388)
2004
27
Management of primary malignant germ cell tumor of the mediastinum. (15342665)
2004
28
Re: Malignant germ cell tumor of the contralateral testis after radiotherapy for testicular intraepithelial neoplasia. (11458101)
2001
29
Langerhans cell histiocytosis after therapy for a malignant germ cell tumor of the central nervous system. (10959908)
2000
30
Levels of beta-human chorionic gonadotropin in cerebrospinal fluid of patients with malignant germ cell tumor can be used to detect early recurrence and monitor the response to treatment. (11007160)
2000
31
Mixed malignant germ cell tumor of the fallopian tube. (10202679)
1999
32
Systemic mast cell disease associated with primary ovarian mixed malignant germ cell tumor. (9865846)
1998
33
Malignant germ cell tumor and urticaria pigmentosa. (8736606)
1995
34
Successful treatment with combined chemotherapy (carboplatin, etoposide, adriamycin, bleomycin) and radiotherapy for recurrent intracranial malignant germ cell tumor: case report]. (7541899)
1995
35
Intracranial malignant germ cell tumor and the Klinefelter syndrome. Case report and review of the literature. (8835213)
1995
36
Current management of malignant germ cell tumor of the ovary. (7661594)
1995
37
Extragonadal malignant germ cell tumor of the lung. (8283903)
1994
38
Malignant germ cell tumor of the mediastinum: a multimodality therapeutic approach. (8054792)
1994
39
Long-term disease-free survival in a child with refractory metastatic malignant germ cell tumor treated by high-dose chemotherapy with autologous bone marrow rescues. (8272012)
1994
40
Neuron-specific enolase: a serum tumor marker in malignant germ-cell tumors? (8397089)
1993
41
Etoposide combination chemotherapy in refractory ovarian malignant germ cell tumor. (2227584)
1990
42
CT and MR imaging of malignant germ cell tumor of the undescended testis. (2569246)
1989
43
Results of the United Kingdom Children's Cancer Study Group's malignant germ cell tumor studies. (2467734)
1989
44
Successful chemotherapeutic decompression of epidural malignant germ cell tumor. (3012301)
1986
45
VP-16 in combinations for first-line treatment of malignant germ-cell tumors and gestational choriocarcinoma. (2579442)
1985
46
Malignant germ cell tumor of the anterior mediastinum with leukemia-like infiltration. (2418628)
1985
47
Case 50-1980: mixed malignant germ-cell tumor. (6259530)
1981
48
Malignant germ cell tumor in situ in a cryptorchid testis. (8206)
1976
49
Malignant germ cell tumor of the testis: spontaneous regression of pulmonary metastases with 7-year survival. (986482)
1976
50
Functioning malignant germ cell tumor of the ovary in a four-and-one-half-year-old girl. Case report. (5891707)
1965

Variations for Malignant Germ Cell Tumor

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Expression for genes affiliated with Malignant Germ Cell Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Germ Cell Tumor

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Pathways for genes affiliated with Malignant Germ Cell Tumor

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51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 5Cell Signaling Technology, 13EMD Millipore
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Pathways related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CDX2, POU5F1
29.8POU5F1, CDX2
39.6KIT, POU5F1
49.5CDX2, POU5F1, AFP
59.2CDX2, TCL1A, POU5F1

Compounds for genes affiliated with Malignant Germ Cell Tumor

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1oestriol469.7AFP, CGB5
2clomiphene citrate469.7CGB5, AFP
3ifosfamide46 1210.6AFP, CGB5
4nitrate469.6AFP, CGB5
5diethylstilbestrol46 30 1211.5CGB5, AFP
6vinblastine46 52 1211.3CGB5, AFP
7oligonucleotide469.2AFP, CDX2, GPC3, KIT
8vincristine46 52 1211.2AFP, CGB5, KIT
9methotrexate52 46 1211.1AFP, KIT, CGB5
10paclitaxel46 52 1211.1AFP, KIT, CGB5
11doxorubicin46 52 1210.9CGB5, KIT, AFP
12glycogen46 259.9AFP, KIT, CGB5
13paraffin468.9KIT, CDX2, CGB5, AFP
14progesterone46 30 62 25 1212.8CGB5, CDX2, KIT, AFP
15oxygen46 259.8AFP, CGB5, LDHA, POU5F1
16steroid468.8KIT, AFP, CDX2, CGB5
17zinc46 259.8CGB5, KPNA2, SALL4, AFP
18actinomycin d468.8AFP, KIT, CGB5
19lactate468.8AFP, LDHA, CGB5, KIT
20fatty acid468.7CGB5, CDX2, AFP
21estrogen468.7CDX2, KIT, AFP, CGB5
22retinoic acid46 259.6CGB5, KIT, POU5F1, AFP
23vegf468.5CGB5, KIT, LDHA, POU5F1, AFP
24tyrosine468.4CDX2, KIT, CGB5, AFP, LDHA
25glucose468.4AFP, LDHA, KIT, CGB5

GO Terms for genes affiliated with Malignant Germ Cell Tumor

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17Gene Ontology
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Cellular components related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.8KIT, PROM1, AFP, GPC3

Biological processes related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1stem cell maintenanceGO:0198279.0KIT, TCL1A, SALL4
2somatic stem cell maintenanceGO:0350199.0CDX2, KIT, POU5F1

Products for genes affiliated with Malignant Germ Cell Tumor

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Sources for Malignant Germ Cell Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet