MCID: MLG088
MIFTS: 38

Malignant Germ Cell Tumor malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Malignant Germ Cell Tumor

Aliases & Descriptions for Malignant Germ Cell Tumor:

Name: Malignant Germ Cell Tumor 50
Malignant Germ Cell Neoplasm 69
Germ Cell Cancer 69

Classifications:



Summaries for Malignant Germ Cell Tumor

MalaCards based summary : Malignant Germ Cell Tumor, also known as malignant germ cell neoplasm, is related to malignant germ cell tumor of cervix uteri and malignant germ cell tumor of corpus uteri. An important gene associated with Malignant Germ Cell Tumor is LDHA (Lactate Dehydrogenase A), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and lymph node, and related phenotype is reproductive system.

Related Diseases for Malignant Germ Cell Tumor

Diseases related to Malignant Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 malignant germ cell tumor of cervix uteri 12.1
2 malignant germ cell tumor of corpus uteri 12.0
3 testicular germ cell cancer 11.0
4 malignant cardiac germ cell tumor 11.0
5 testicular cancer 11.0
6 testicular malignant germ cell cancer 11.0
7 adult teratoma 10.2 AFP ALPP
8 infiltrating renal pelvis transitional cell carcinoma 10.2 AFP CGB5
9 dementia 10.2 AFP CGB5
10 novak syndrome 10.2 AFP CGB5
11 atrophic rhinitis 10.2 AFP CGB5
12 renal pelvis transitional cell carcinoma 10.2 AFP CGA
13 antisynthetase syndrome 10.2 CGA CGB5
14 true unicornuate uterus 10.2 AFP CGA
15 pontine hemorrhage 10.2 AFP CGA
16 klinefelter's syndrome 10.2 AFP ALPP
17 severe combined immunodeficiency 10.2 AFP CGA
18 trypanosomiasis, human east-african 10.2 AFP CGA
19 chromosome 11q duplication 10.2 AFP CGA
20 retroperitoneal hemangiopericytoma 10.2 AFP KPNA2
21 microcephaly, seizures, and developmental delay 10.2 CGA CGB5
22 lymph node disease 10.1 AFP CGA
23 ophthalmoplegia, progressive, with scrotal tongue and mental deficiency 10.1 AFP CGA
24 hair follicle neoplasm 10.1 AFP KPNA2
25 pneumonia 10.1 AFP ALPP
26 esophagus sarcoma 10.1 ALPP AR
27 periodic fever, aphthous stomatitis, pharyngitis and adenitis 10.1 AR CGA
28 intraventricular meningioma 10.1 AR CGA
29 ulceroglandular tularemia 10.0 AR ESR2
30 borderline personality disorder 10.0 AR ESR2
31 osteogenesis imperfecta 10.0 AR ESR2
32 parameningeal embryonal rhabdomyosarcoma 10.0 CGA CGB5
33 gallbladder papillomatosis 10.0 ALPP ESR2
34 carbuncle 10.0 AR ESR2
35 jackson-weiss syndrome 10.0 ALPPL2 CGB5
36 exocervical carcinoma 10.0 AR ESR2
37 mature teratoma 9.9 ALPP AR ESR2
38 teratoma 9.9
39 prostate cancer, hereditary, x-linked 1 9.9 AFP AR ESR2
40 hypospadias 1, x-linked 9.9 AR CGA
41 gonadoblastoma 9.8
42 mediastinitis 9.8
43 capillary disease 9.8 AR CGA
44 congenital articular rigidity 9.8 ALPPL2 AR CGA
45 ovarian mucinous cystadenocarcinoma 9.8 ALPP ALPPL2 CGA CGB5
46 mast cell disease 9.7
47 cryptorchidism 9.7
48 neuronitis 9.7
49 hepatitis 9.7
50 leukemia 9.7

Graphical network of the top 20 diseases related to Malignant Germ Cell Tumor:



Diseases related to Malignant Germ Cell Tumor

Symptoms & Phenotypes for Malignant Germ Cell Tumor

MGI Mouse Phenotypes related to Malignant Germ Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.1 AFP ALPPL2 AR CGA ESR2 FGF4

Drugs & Therapeutics for Malignant Germ Cell Tumor

Drugs for Malignant Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 596)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
2
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
3
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 41575-94-4 10339178 498142 38904
4
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1 3778-73-2 3690
5
Mechlorethamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-75-2 4033
6
Dacarbazine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 4342-03-4 5351166
7
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 85622-93-1 5394
8
Lenograstim Approved Phase 4,Phase 2,Phase 3,Phase 1 135968-09-1
9
Vindesine Approved Phase 4 59917-39-4, 53643-48-4 40839
10
Nicotine Approved Phase 4 54-11-5 942 89594
11
Etanercept Approved, Investigational Phase 4 185243-69-0
12
Pancrelipase Approved Phase 4,Phase 3,Phase 2,Phase 1 53608-75-6
13
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
14 pancreatic polypeptide Phase 4,Phase 2,Phase 3,Phase 1
15 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
16 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1
17 Adjuvants, Immunologic Phase 4,Phase 3,Phase 1,Phase 2
18 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
21 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1
23 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
24 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
25 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
26 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1
28 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2,Phase 1
29 Liver Extracts Phase 4,Phase 3,Phase 2,Phase 1
30 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
31 Antimitotic Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1
34 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1
35 pancreatin Phase 4,Phase 3,Phase 2,Phase 1
36 Coagulants Phase 4
37 Hemostatics Phase 4
38 Fibrin Tissue Adhesive Phase 4
39 Fluorodeoxyglucose F18 Phase 4,Phase 2,Phase 1,Early Phase 1
40
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
41
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
42
Vinblastine Approved Phase 3,Phase 2,Phase 1 865-21-4 13342 241903
43
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
44
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
45
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
46
Aminolevulinic acid Approved Phase 3,Phase 2,Phase 1 106-60-5 137
47
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
48
Bleomycin Approved Phase 3,Phase 2 11056-06-7 5360373
49
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
50
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 6857599, 9887054 43805

Interventional clinical trials:

(show top 50) (show all 1281)
id Name Status NCT ID Phase
1 Standard Palliative Care Versus Standard Palliative Care Plus Polychemotherapy in Metastasized Malignant Melanoma Unknown status NCT00226473 Phase 4
2 Disease-Specific Questionnaire in Assessing Quality of Life in Patients With Gastrointestinal-Related Neuroendocrine Tumors Unknown status NCT00454376 Phase 4
3 Can We Miss Pigmented Lesions in Psoriasis Patients? Completed NCT01053819 Phase 4
4 Post-Operative Drainage Following Lymph Node Dissection Completed NCT00324272 Phase 4
5 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Recruiting NCT01424839 Phase 4
6 Nonfunctional Pancreatic NET and PET Imaging Recruiting NCT02621541 Phase 4
7 A Comparison of Single Versus Double Evacuation for Treatment of Hydatidiform Mole Recruiting NCT01630954 Phase 4
8 Stereotactic Body Radiotherapy for Head and Neck Tumors Active, not recruiting NCT01344356 Phase 4
9 A National Phase IV Study With Ipilimumab for Patients With Advanced Malignant Melanoma. Active, not recruiting NCT02068196 Phase 4
10 An Open-Label Study of Zelboraf (Vemurafenib) in Patients With Braf V600 Mutation Positive Metastatic Melanoma Active, not recruiting NCT01898585 Phase 4
11 G-CSF Alone or Combination With GM-CSF on Prevention and Treatment of Infection in Children With Malignant Tumor Not yet recruiting NCT02933333 Phase 4
12 Effect of Cytokine-induced Killer Cells for Advanced Malignant Gliomas Not yet recruiting NCT02496988 Phase 4
13 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3
14 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3
15 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
16 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3
17 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3
18 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3
19 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
20 Safety and Efficacy Study of Intracranially Implanted Carmustine to Treat Newly Diagnosed Malignant Glioma Unknown status NCT01656980 Phase 3
21 Interleukin-2 With or Without Histamine Dihydrochloride in Treating Patients With Stage IV Melanoma Metastatic to the Liver Unknown status NCT00039234 Phase 3
22 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Unknown status NCT00346164 Phase 3
23 Interferon Alfa With or Without Vaccine Therapy in Treating Patients With Metastatic Melanoma Unknown status NCT00002767 Phase 3
24 Standard High-Dose Alpha Interferon Versus Intermittent High-Dose Alpha Interferon Unknown status NCT00226408 Phase 3
25 Vaccine Therapy for Patients With Stage III Melanoma Unknown status NCT00052130 Phase 3
26 Vaccine Therapy for Patients With Stage IV Melanoma Unknown status NCT00052156 Phase 3
27 Combination Chemotherapy and Bevacizumab in Treating Patients With Advanced Neuroendocrine Tumors Unknown status NCT00227617 Phase 2, Phase 3
28 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3
29 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3
30 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3
31 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3
32 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3
33 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3
34 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3
35 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
36 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
37 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3
38 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
39 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
40 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
41 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
42 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3
43 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
44 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3
45 Fluorescence-guided Resection of Malignant Gliomas With 5-Aminolevulinic Acid Completed NCT00241670 Phase 3
46 High Light and Low Light Dose PDT in Glioma Completed NCT00118222 Phase 3
47 A Trial of ABI-007 Versus Dacarbazine in Previously Untreated Patients With Metastatic Malignant Melanoma Completed NCT00864253 Phase 3
48 Imaging Malignant Glioma With 68Ga-DOTATOC PET/CT Completed NCT01460706 Phase 2, Phase 3
49 A Study of Continued Treatment Among Participants Who Have Responded to Peginterferon Alfa-2a (Pegasys®) or Recombinant Interferon Alfa-2a (Roferon-A®) in Prior Clinical Studies Completed NCT02829775 Phase 2, Phase 3
50 Everolimus and Octreotide in Patients With Advanced Carcinoid Tumor Completed NCT00412061 Phase 3

Search NIH Clinical Center for Malignant Germ Cell Tumor

Genetic Tests for Malignant Germ Cell Tumor

Anatomical Context for Malignant Germ Cell Tumor

MalaCards organs/tissues related to Malignant Germ Cell Tumor:

39
Ovary, Testis, Lymph Node, Lung, Testes, Prostate, Pineal

Publications for Malignant Germ Cell Tumor

Articles related to Malignant Germ Cell Tumor:

(show top 50) (show all 78)
id Title Authors Year
1
Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative. ( 26485622 )
2016
2
Swyer's Syndrome with Mixed Ovarian Malignant Germ Cell Tumor and Ovarian Gonadoblastoma. ( 27411466 )
2016
3
Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis. ( 25769700 )
2015
4
Metastatic Treated Malignant Germ Cell Tumors: Is SALL4 a Better Marker Than Placental Alkaline Phosphatase? ( 25906119 )
2015
5
Neo-adjuvant chemotherapy in the treatment of advanced malignant germ cell tumors of ovary. ( 24145115 )
2014
6
Two case reports of a malignant germ cell tumor of ovary and a granulosa cell tumor: interest of tumoral immunochemistry in the identification and management. ( 24982844 )
2014
7
Feto-maternal outcomes of pregnancy complicated by ovarian malignant germ cell tumor: a systematic review of literature. ( 25150953 )
2014
8
Impact of central surgical review in a study of malignant germ cell tumors. ( 25783295 )
2014
9
Sacrococcygeal malignant germ cell tumor (SC-MGCT) with intraspinal extension. ( 24952799 )
2014
10
Brain metastases during follow-up of children and adolescents with extracranial malignant germ cell tumors: risk adapted management decision tree analysis based on data of the MAHO/MAKEI-registry. ( 22693072 )
2013
11
Outcomes of combined modality therapy for patients with stage III or IV mediastinal malignant germ cell tumors. ( 23553421 )
2013
12
Usefulness of OCT4/3 immunostain in pediatric malignant germ cell tumors. ( 22506928 )
2013
13
Utility of OCT3/4, TSPY and I^-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads. ( 23396295 )
2013
14
High-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for recurrent primary mediastinal malignant germ cell tumor: A case report. ( 24373121 )
2013
15
LIN28 Expression in malignant germ cell tumors downregulates let-7 and increases oncogene levels. ( 23774216 )
2013
16
Is there a role for carboplatin in the treatment of malignant germ cell tumors? A systematic review of adult and pediatric trials. ( 22976789 )
2013
17
Extracranial malignant germ cell tumors. ( 22706911 )
2012
18
CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubules. ( 22895825 )
2012
19
A rare case of solitary metastatic non-seminomatous malignant germ cell tumor to the prostate. ( 23040630 )
2012
20
Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis. ( 22962582 )
2012
21
Delayed Recognition of Disorders of Sex Development (DSD): A Missed Opportunity for Early Diagnosis of Malignant Germ Cell Tumors. ( 22315593 )
2012
22
Diagnostic utility of CD117, CD133, SALL4, OCT4, TCL1 and glypican-3 in malignant germ cell tumors of the ovary. ( 22448662 )
2012
23
Malignant germ cell tumors associated with Swyer syndrome. ( 21225934 )
2011
24
Identification of microRNAs From the miR-371~373 and miR-302 clusters as potential serum biomarkers of malignant germ cell tumors. ( 21173133 )
2011
25
Unusual liver locations of growing teratoma syndrome in ovarian malignant germ cell tumors. ( 24371596 )
2011
26
Evaluation of neoadjuvant therapy in patients with nongerminomatous malignant germ cell tumors. ( 21456918 )
2011
27
Therapy-associated secondary tumors in patients with non-germinomatous malignant germ cell tumors. ( 21533838 )
2011
28
Family history of cancer and malignant germ cell tumors in children: a report from the Children's Oncology Group. ( 19842050 )
2010
29
Rete testis invasion by malignant germ cell tumor and/or intratubular germ cell neoplasia: what is the significance of this finding? ( 20573373 )
2010
30
Proton beam therapy for loco-regional control of a recurrent mixed malignant germ cell tumor of the skull in a 22-month-old girl. ( 20514623 )
2010
31
Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. ( 20332240 )
2010
32
Modified grading system for clinical outcome of intracranial non-germinomatous malignant germ cell tumors. ( 22966355 )
2010
33
Clinicopathologic characteristics of malignant germ cell tumors in the ovaries of Korean women: a Korean Gynecologic Oncology Group Study. ( 19258947 )
2009
34
Survival after an antiangiogenetic therapy and surgery in a wide spread growing teratoma originating from a testicular mixed malignant germ cell tumor. ( 19437360 )
2009
35
Carbon 11-labeled methionine positron emission tomography for detection of residual viable tumor cells after adjuvant therapy in nongerminomatous malignant germ cell tumors in 2 cases including an autopsy case. ( 18262610 )
2009
36
Diagnostic value of lectin reactive alpha-fetoprotein for neoinfantile hepatic tumors and malignant germ cell tumors: preliminary study. ( 18525461 )
2008
37
Chemotherapy for the treatment of children and adolescents with malignant germ cell tumors. ( 18612144 )
2008
38
False-positive serum human chorionic gonadotropin (HCG) in a male patient with a malignant germ cell tumor of the testis: a case report and review of the literature. ( 18984875 )
2008
39
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. ( 18571705 )
2008
40
Malignant germ cell tumors of the ovary: a review of 41 cases and risk factors for recurrence. ( 19115694 )
2008
41
Regression pattern of alpha fetoprotein level changed after treatment of malignant germ cell tumor. ( 18575279 )
2008
42
Pediatric malignant germ cell tumors show characteristic transcriptome profiles. ( 18519683 )
2008
43
Comprehensive staging allows for excellent outcome in patients with localized malignant germ cell tumor of the ovary. ( 18948812 )
2008
44
Viable malignant germ cell tumor in the postchemotherapy retroperitoneal lymph node dissection specimen: can it be predicted using clinical parameters? ( 16944534 )
2006
45
High lactate dehydrogenase isoenzyme 1 in a patient with malignant germ cell tumor is attributable to aberrant methylation of the LDHA gene. ( 15297388 )
2004
46
Management of primary malignant germ cell tumor of the mediastinum. ( 15342665 )
2004
47
Congenital mixed malignant germ cell tumor involving cerebrum and orbit. ( 12825484 )
2003
48
Re: organ sparing surgery for malignant germ cell tumor of the testis. ( 12187245 )
2002
49
Organ sparing surgery for malignant germ cell tumor of the testis. ( 11696727 )
2001
50
Re: Malignant germ cell tumor of the contralateral testis after radiotherapy for testicular intraepithelial neoplasia. ( 11458101 )
2001

Variations for Malignant Germ Cell Tumor

Expression for Malignant Germ Cell Tumor

Search GEO for disease gene expression data for Malignant Germ Cell Tumor.

Pathways for Malignant Germ Cell Tumor

Pathways related to Malignant Germ Cell Tumor according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.46 AFP ALPP FGF4
2 10.91 AR CGA
3 10.16 ALPP ALPPL2
4 9.83 ALPP ALPPL2

GO Terms for Malignant Germ Cell Tumor

Cellular components related to Malignant Germ Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 AFP ALPPL2 CGA CGB5 ESR2 FGF4

Biological processes related to Malignant Germ Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid hormone mediated signaling pathway GO:0043401 9.16 AR ESR2
2 cell-cell signaling GO:0007267 9.02 AR CGA CGB5 ESR2 FGF4
3 peptide hormone processing GO:0016486 8.96 CGA CGB5

Molecular functions related to Malignant Germ Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.26 AR ESR2
2 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.16 AR ESR2
3 steroid binding GO:0005496 8.96 AR ESR2
4 alkaline phosphatase activity GO:0004035 8.62 ALPP ALPPL2

Sources for Malignant Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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