MCID: MLG088
MIFTS: 25

Malignant Germ Cell Tumor malady

Cancer diseases category

Summaries for Malignant Germ Cell Tumor

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MalaCards: Malignant Germ Cell Tumor is related to gonadoblastoma and hepatitis. An important gene associated with Malignant Germ Cell Tumor is SALL4 (sal-like 4 (Drosophila)), and among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell and Oct4 in Mammalian ESC Pluripotency. The compounds glucose and oestriol have been mentioned in the context of this disorder. Related mouse phenotypes are reproductive system and tumorigenesis.

Aliases & Classifications for Malignant Germ Cell Tumor

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42NIH Rare Diseases
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Classifications:

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Global: Cancer diseases


Aliases & Descriptions:

malignant germ cell tumor 42


Related Diseases for Malignant Germ Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Germ Cell Tumors family:

malignant germ cell tumor

Diseases related to Malignant Germ Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 73)
idRelated DiseaseScoreTop Affiliating Genes
1gonadoblastoma30.2POU5F1, KIT
2hepatitis30.2AFP, GPC3
3leukemia30.2TCL1A, CDX2, PROM1, KIT
4choriocarcinoma30.2GPC3, AFP, CGB5
5malignant germ cell tumor of the cervix uteri10.4
6malignant teratoma10.3
7mediastinitis10.3
8malignant germ cell tumor of the corpus uteri10.3
9malignant cardiac germ cell tumor10.2
10cryptorchidism10.2
11malignant tumor of undescended testis10.2
12neuronitis10.2
13malignant histiocytosis10.2
14urticaria pigmentosa10.2
15central nervous system germ cell tumor10.2
16dysgerminoma of ovary10.2
17extragonadal germ cell malignant tumor10.2
18gestational choriocarcinoma10.2
19histiocytosis10.2
20langerhans-cell histiocytosis10.2
21ovarian disease10.2
22prostatitis10.2
23testicular malignant germ cell cancer10.2
24urticaria10.2
25esophagitis10.0CDX2
26pancreatic cancer10.0CDX2
27leydig cell tumor10.0CGB5
28pituitary adenoma10.0POU5F1
29germ cell tumors10.0KIT
30anencephaly10.0AFP
31myeloid leukemia10.0KIT
32sertoli-leydig cell tumor10.0AFP
33malignant mesothelioma10.0GPC3
34azoospermia10.0CGB5
35colorectal cancer10.0PROM1, CDX2
36germ cell cancer10.0AFP
37extragonadal germ cell tumor10.0CGB5, AFP
38thymus cancer10.0KIT
39sertoli cell tumor10.0ENO2
40lung cancer10.0ENO2
41embryonal cancer10.0POU5F1, AFP
42rhabdomyosarcoma10.0ENO2
43endodermal sinus tumor10.0AFP, CGB5
44dermatofibrosarcoma protuberans10.0KIT
45testicular cancer10.0CGB5, AFP
46anaplastic large cell lymphoma10.0ENO2
47hepatocellular adenoma10.0AFP, GPC3
48adenoma10.0CDX2, ENO2
49pheochromocytoma10.0ENO2, CDX2
50cholangiocarcinoma10.0GPC3, AFP, CDX2

Graphical network of the top 20 diseases related to Malignant Germ Cell Tumor:



Diseases related to malignant germ cell tumor

Clinical Features for Malignant Germ Cell Tumor

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Drugs & Therapeutics for Malignant Germ Cell Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Germ Cell Tumor

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Anatomical Context for Malignant Germ Cell Tumor

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Animal Models for Malignant Germ Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Germ Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.5AFP, CDX2, TCL1A
2MP:00020068.8LDHA, KIT, CDX2, AFP, PROM1
3MP:00053818.5KIT, GPC3, SALL4, POU5F1, CDX2
4MP:00053858.3SALL4, PROM1, CDX2, GPC3, KIT, LDHA
5MP:00107687.7SALL4, PROM1, AFP, POU5F1, CDX2, GPC3
6MP:00053847.5SALL4, PROM1, POU5F1, CDX2, GPC3, KIT

Publications for Malignant Germ Cell Tumor

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Genetic Variations for Malignant Germ Cell Tumor

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Expression for genes affiliated with Malignant Germ Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Germ Cell Tumor

Search GEO for disease gene expression data for Malignant Germ Cell Tumor.

Pathways for genes affiliated with Malignant Germ Cell Tumor

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51QIAGEN, 4Cell Signaling Technology, 12EMD Millipore
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Pathways related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CDX2, POU5F1
29.9CDX2, POU5F1
39.6AFP, POU5F1, CDX2
49.4TCL1A, CDX2, POU5F1

Compounds for genes affiliated with Malignant Germ Cell Tumor

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1glucose4410.1CGB5
2oestriol449.9AFP, CGB5
3clomiphene citrate449.7AFP, CGB5
4toluidine449.6ENO2, KIT
5vincristine44 49 1111.5CGB5, AFP, KIT
6steroid449.3CDX2, AFP, CGB5
7diethylstilbestrol44 28 1111.1ENO2, AFP, CGB5
8oligonucleotide449.0AFP, CDX2, GPC3, KIT
9spec-t449.0AFP, ENO2
10thymidine44 249.9AFP, CDX2, KIT, ENO2
11dmso448.9CGB5, AFP, ENO2
12methotrexate44 49 1110.7CGB5, AFP, KIT, ENO2
13ribonucleic acid448.7ENO2, KIT, CGB5
14glycogen44 249.6ENO2, KIT, AFP, CGB5
15etoposide44 49 59 1111.6ENO2, AFP, CGB5
16testosterone44 59 11 2411.4CGB5, AFP, KIT, ENO2
17paraffin448.4CGB5, AFP, CDX2, KIT, ENO2
18progesterone44 59 28 11 2412.4CGB5, AFP, CDX2, KIT, ENO2
19retinoic acid44 249.3CGB5, AFP, POU5F1, KIT, ENO2
20oxygen44 249.3CGB5, AFP, POU5F1, ENO2, LDHA
21lactate448.3CGB5, AFP, KIT, ENO2, LDHA
22lipid448.1CGB5, PROM1, AFP, GPC3, ENO2
23vegf448.0LDHA, ENO2, KIT, POU5F1, AFP, CGB5
24tyrosine447.9CGB5, AFP, CDX2, KIT, ENO2, LDHA

GO Terms for genes affiliated with Malignant Germ Cell Tumor

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16Gene Ontology
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Biological processes related to Malignant Germ Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatic stem cell maintenanceGO:0350199.9CDX2, POU5F1
2stem cell maintenanceGO:0198279.0TCL1A, KIT, SALL4

Products for genes affiliated with Malignant Germ Cell Tumor

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Sources for Malignant Germ Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet