MCID: MLG067
MIFTS: 36

Malignant Giant Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Malignant Giant Cell Tumor

MalaCards integrated aliases for Malignant Giant Cell Tumor:

Name: Malignant Giant Cell Tumor 12 14
Malignant Tumor, Giant Cell Type 12 69
Malignant Giant Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2705
NCIt 46 C4090
SNOMED-CT 64 83950009
UMLS 69 C0334229

Summaries for Malignant Giant Cell Tumor

MalaCards based summary : Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to malignant giant cell tumor of soft parts and bone giant cell sarcoma. An important gene associated with Malignant Giant Cell Tumor is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Transcriptional misregulation in cancer. The drugs Fentanyl and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and uterus.

Related Diseases for Malignant Giant Cell Tumor

Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor of soft parts 33.3 ACP5 ACTC1 S100B
2 bone giant cell sarcoma 31.5 H3F3A H3F3B TP53
3 pigmented villonodular synovitis 29.8 ACP5 TP53
4 dermatofibrosarcoma protuberans 29.2 ACTC1 S100B TP53
5 leiomyosarcoma 29.2 ACTC1 S100B TP53
6 malignant giant cell tumor of the tendon sheath 12.3
7 paget disease of bone 6 11.1
8 giant cell tumor 10.6
9 myopericytoma 10.3 ACTC1 S100B
10 ossifying fibromyxoid tumor 10.2 ACTC1 S100B
11 syringocystadenoma papilliferum 10.2 ACTC1 S100B
12 angiocentric glioma 10.2 ACTC1 S100B
13 pleomorphic liposarcoma 10.2 ACTC1 S100B
14 cutaneous fibrous histiocytoma 10.2 ACTC1 S100B
15 spindle cell sarcoma 10.2 ACTC1 S100B
16 dendritic cell tumor 10.2 ACTC1 S100B
17 glioma susceptibility 1 10.2 H3F3A TP53
18 brain stem glioma 10.1 H3F3A TP53
19 hemangiopericytoma, malignant 10.1 ACTC1 S100B
20 fibrillary astrocytoma 10.1 H3F3A TP53
21 chordoid glioma 10.1 S100B TP53
22 polymorphous low-grade adenocarcinoma 10.1 ACTC1 S100B
23 microglandular adenosis 10.1 S100B TP53
24 malignant fibroxanthoma 10.1 ACTC1 S100B
25 papilloma of choroid plexus 10.1 S100B TP53
26 glycogen-rich clear cell breast carcinoma 10.1 ACTC1 TP53
27 dedifferentiated liposarcoma 10.1 ACTC1 TP53
28 embryonal sarcoma 10.0 S100B TP53
29 glomus tumor 10.0 ACTC1 TP53
30 cerebral primitive neuroectodermal tumor 10.0 S100B TP53
31 myoepithelioma 10.0 ACTC1 S100B
32 necrotizing sialometaplasia 10.0 ACTC1 TP53
33 clear cell chondrosarcoma 10.0 H3F3A H3F3B
34 hidradenocarcinoma 10.0 S100B TP53
35 granulosa cell tumor of the ovary 10.0 ACTC1 TP53
36 desmoplastic small round cell tumor 10.0 ACTC1 S100B
37 cellular schwannoma 10.0 S100B TP53
38 adult astrocytic tumour 10.0 H3F3A H3F3B
39 diffuse intrinsic pontine glioma 10.0 H3F3A H3F3B
40 optic nerve glioma 10.0 S100B TP53
41 chondroblastoma 9.9 H3F3A H3F3B
42 ganglioglioma 9.9 S100B TP53
43 synovitis 9.9
44 villonodular synovitis 9.9
45 synovium cancer 9.8
46 spiradenoma 9.8 ACTC1 S100B TP53
47 pleomorphic adenoma 9.8 ACTC1 S100B TP53
48 inflammatory myofibroblastic tumor 9.8 ACTC1 S100B TP53
49 gliosarcoma 9.8 ACTC1 S100B TP53
50 malignant peripheral nerve sheath tumor 9.8 ACTC1 S100B TP53

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to Malignant Giant Cell Tumor

Symptoms & Phenotypes for Malignant Giant Cell Tumor

Drugs & Therapeutics for Malignant Giant Cell Tumor

Drugs for Malignant Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
3 Liver Extracts Phase 3
4 Adjuvants, Anesthesia Phase 3
5 Analgesics Phase 3
6 Analgesics, Opioid Phase 3
7 Anesthetics Phase 3
8 Anesthetics, General Phase 3
9 Anesthetics, Intravenous Phase 3
10 Central Nervous System Depressants Phase 3
11 Narcotics Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Cola Nutraceutical Phase 3
14
nivolumab Approved Phase 2 946414-94-4
15 Antibodies Phase 2
16 Antibodies, Monoclonal Phase 2
17 Immunoglobulins Phase 2
18
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
19 Alkylating Agents
20 Antirheumatic Agents
21 Immunosuppressive Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
3 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733 cyclophosphamide

Search NIH Clinical Center for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

Anatomical Context for Malignant Giant Cell Tumor

MalaCards organs/tissues related to Malignant Giant Cell Tumor:

38
Bone, Liver, Uterus, Prostate, Lung, Kidney, Skin

Publications for Malignant Giant Cell Tumor

Articles related to Malignant Giant Cell Tumor:

(show top 50) (show all 63)
# Title Authors Year
1
H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone. ( 28505000 )
2017
2
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report. ( 26951080 )
2016
3
Treatment and outcome of malignant giant cell tumor in the spine. ( 26040486 )
2015
4
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. ( 26414220 )
2015
5
Malignant giant cell tumor of the rib with lung metastasis in a man. ( 25276374 )
2014
6
Malignant giant cell tumor of the tendon sheath. ( 23981429 )
2013
7
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. ( 24436827 )
2013
8
Histological and clinical characteristics of malignant giant cell tumor of bone. ( 22350004 )
2012
9
Secondary malignant giant cell tumor of the clivus: case report. ( 22277296 )
2012
10
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. ( 21924561 )
2011
11
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. ( 21237496 )
2011
12
Malignant giant cell tumor of the vulva. ( 19952930 )
2010
13
Malignant giant cell tumor in the posterior fossa of a neonate. ( 20192645 )
2010
14
Primary malignant giant-cell tumor of bone has high survival rate. ( 19902306 )
2010
15
Fungating primary locally malignant giant cell tumor of ulna: a case report. ( 18552892 )
2008
16
Primary malignant giant cell tumor of bone: a series of three rare cases. ( 17592717 )
2007
17
Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. ( 16205965 )
2006
18
Primary de novo malignant giant cell tumor of kidney: a case report. ( 15207006 )
2004
19
Malignant giant cell tumor of the tendon sheath. ( 14693023 )
2004
20
Malignant giant cell tumor of soft parts. ( 14997349 )
2004
21
Malignant giant cell tumor of the sphenoid. ( 12715335 )
2003
22
Malignant giant cell tumor of soft parts in a mare. ( 14524631 )
2003
23
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. ( 11220389 )
2001
24
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). ( 11079016 )
2000
25
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. ( 10496598 )
1999
26
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). ( 9042281 )
1997
27
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. ( 8319177 )
1993
28
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. ( 8230758 )
1993
29
Significance of chromosomal abnormalities in a malignant giant cell tumor of bone. ( 1756489 )
1991
30
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. ( 2317762 )
1990
31
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. ( 2175663 )
1990
32
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. ( 2554283 )
1989
33
Malignant giant cell tumor of soft parts presenting as a skin tumor. ( 2658646 )
1989
34
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. ( 2545593 )
1989
35
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. ( 3115731 )
1987
36
Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients. ( 3745247 )
1986
37
Malignant giant cell tumor of tendon sheath. Report of a case. ( 2994359 )
1985
38
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. ( 6465100 )
1984
39
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. ( 6490003 )
1984
40
Malignant giant cell tumor of the frontal bone. ( 6585707 )
1984
41
Malignant giant-cell tumor of the distal end of the radius treated by a free vascularized fibular transplant. ( 7240328 )
1981
42
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. ( 6937839 )
1981
43
Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study. ( 7226022 )
1981
44
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. ( 7270164 )
1981
45
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. ( 314048 )
1979
46
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. ( 379085 )
1979
47
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. ( 227563 )
1979
48
Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. ( 212864 )
1978
49
The importance of recognizing malignant giant cell tumor of soft parts. ( 277073 )
1978
50
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. ( 195704 )
1977

Variations for Malignant Giant Cell Tumor

Expression for Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for Malignant Giant Cell Tumor

GO Terms for Malignant Giant Cell Tumor

Cellular components related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 8.96 H3F3A H3F3B
2 nuclear nucleosome GO:0000788 8.62 H3F3A H3F3B

Biological processes related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of gene silencing by miRNA GO:0060964 9.48 H3F3A H3F3B
2 positive regulation of cell growth GO:0030307 9.46 H3F3A H3F3B
3 regulation of megakaryocyte differentiation GO:0045652 9.43 H3F3A H3F3B
4 positive regulation of gene expression, epigenetic GO:0045815 9.4 H3F3A H3F3B
5 response to cytokine GO:0034097 9.37 ACP5 TP53
6 response to hormone GO:0009725 9.32 H3F3A H3F3B
7 negative regulation of gene expression, epigenetic GO:0045814 9.26 H3F3A H3F3B
8 chromatin silencing at rDNA GO:0000183 9.16 H3F3A H3F3B
9 telomere organization GO:0032200 8.96 H3F3A H3F3B
10 DNA replication-independent nucleosome assembly GO:0006336 8.62 H3F3A H3F3B

Molecular functions related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.16 H3F3A H3F3B
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.96 H3F3A H3F3B
3 nucleosomal DNA binding GO:0031492 8.62 H3F3A H3F3B

Sources for Malignant Giant Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....