MCID: MLG067
MIFTS: 37

Malignant Giant Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Malignant Giant Cell Tumor

MalaCards integrated aliases for Malignant Giant Cell Tumor:

Name: Malignant Giant Cell Tumor 12 14
Malignant Tumor, Giant Cell Type 12 69
Malignant Giant Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2705
NCIt 47 C4090
SNOMED-CT 64 83950009
UMLS 69 C0334229

Summaries for Malignant Giant Cell Tumor

MalaCards based summary : Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to malignant giant cell tumor of soft parts and malignant giant cell tumor of the tendon sheath. An important gene associated with Malignant Giant Cell Tumor is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Transcriptional misregulation in cancer. The drugs Carmustine and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow.

Related Diseases for Malignant Giant Cell Tumor

Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor of soft parts 12.2
2 malignant giant cell tumor of the tendon sheath 12.2
3 paget disease of bone 6 11.0
4 bone giant cell sarcoma 11.0
5 giant cell tumor 10.5
6 juvenile nasopharyngeal angiofibroma 10.5 ACTC1 S100B
7 spleen angiosarcoma 10.5 ACTC1 S100B
8 myoma 10.5 ACTC1 S100B
9 papillary glioneuronal tumor 10.5 ACTC1 S100B
10 spindle cell liposarcoma 10.4 ACTC1 S100B
11 juvenile xanthogranuloma 10.4 ACTC1 S100B
12 coronary restenosis 10.4 ACTC1 S100B
13 dense deposit disease 10.4 ACTC1 S100B
14 patent ductus arteriosus and bicuspid aortic valve with hand anomalies 10.3 ACTC1 S100B
15 polyosteolysis/hyperostosis syndrome 10.3 ACTC1 S100B
16 leiomyoma cutis 10.3 ACTC1 TP53
17 retinal detachment 10.2 ACTC1 TP53
18 dextrocardia with situs inversus 10.2 ACTC1 S100B
19 pleural empyema 10.2 S100B TP53
20 secondary pulmonary hemosiderosis 10.2 ACTC1 TP53
21 congenital disorder of glycosylation, type if 10.2 H3F3A TP53
22 group b strep disease in newborns 10.2 ACTC1 TP53
23 breast fibrosarcoma 10.2 S100B TP53
24 glomangioma 10.2 ACTC1 TP53
25 brainstem intraparenchymal clear cell meningioma 10.2 H3F3A TP53
26 plasmodium ovale malaria 10.2 ACTC1 TP53
27 childhood infratentorial neoplasm 10.2 H3F3A TP53
28 schwannoma of jugular foramen 10.1 H3F3A TP53
29 enamel hypoplasia cataract hydrocephaly 10.1 S100B TP53
30 vulvar keratoacanthoma-like carcinoma 10.1 S100B TP53
31 hip subluxation 10.1 S100B TP53
32 c-p angle neurinoma 10.1 S100B TP53
33 cervical adenomyoma 10.0 S100B TP53
34 sternum cancer 10.0 S100B TP53
35 localized pulmonary fibrosis 10.0 ACP5 ACTC1 S100B
36 early myoclonic encephalopathy 10.0 H3F3A H3F3B
37 central nervous system disease 9.9 ACTC1 TP53
38 pulmonary venoocclusive disease 9.9 ACTC1 S100B TP53
39 superior vena cava angiosarcoma 9.9 ACTC1 S100B TP53
40 neutrophil immunodeficiency syndrome 9.9 ACTC1 S100B TP53
41 mixed extragonadal germ cell cancer 9.9 ACTC1 S100B TP53
42 adenosarcoma 9.9 ACTC1 S100B TP53
43 grade iii astrocytoma 9.9 ACTC1 S100B TP53
44 bladder urachal squamous cell carcinoma 9.9 ACTC1 S100B TP53
45 gastrointestinal stromal tumor 9.9 ACTC1 S100B TP53
46 villonodular synovitis 9.9
47 pigmented villonodular synovitis 9.9
48 synovitis 9.9
49 periventricular nodular heterotopia 6 9.8 S100B TP53
50 cystadenoma 9.8 RPS13 TP53

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to Malignant Giant Cell Tumor

Symptoms & Phenotypes for Malignant Giant Cell Tumor

Drugs & Therapeutics for Malignant Giant Cell Tumor

Drugs for Malignant Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 185)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carmustine Approved Phase 3,Phase 1,Phase 2 154-93-8 2578
2
Lomustine Approved Phase 3 13010-47-4 3950
3
Procarbazine Approved Phase 3,Phase 2 671-16-9 4915
4
Trioxsalen Approved Phase 3 3902-71-4 5585
5
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 4342-03-4 5351166
6
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1 85622-93-1 5394
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
8
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
9
Isotretinoin Approved Phase 3,Phase 1 4759-48-2 5538 5282379
10
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 1 302-79-4 5538
11 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
12 Alkylating Agents Phase 3,Phase 2,Phase 1
13 Dermatologic Agents Phase 3,Phase 2,Phase 1
14 Dihematoporphyrin Ether Phase 3
15 Ether Phase 3
16 Photosensitizing Agents Phase 3,Phase 2,Phase 1
17 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
18 Liver Extracts Phase 3,Phase 1,Phase 2
19 Adjuvants, Anesthesia Phase 3,Phase 1
20 Analgesics Phase 3,Phase 2,Phase 1
21 Analgesics, Opioid Phase 3
22 Anesthetics Phase 3,Phase 1
23 Anesthetics, General Phase 3,Phase 1
24 Anesthetics, Intravenous Phase 3,Phase 1
25 Narcotics Phase 3
26 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
27 O(6)-benzylguanine Phase 3,Phase 1
28 Antimitotic Agents Phase 3,Phase 1
29 Antineoplastic Agents, Phytogenic Phase 3,Phase 1,Phase 2
30 Anesthetics, Inhalation Phase 3
31 Hematoporphyrin Derivative Phase 3
32 Hematoporphyrins Phase 3
33 Cola Nutraceutical Phase 3
34
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904
35
Tamoxifen Approved Phase 2 10540-29-1 2733526
36
Ethanol Approved Phase 1, Phase 2 64-17-5 702
37
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
38
Irinotecan Approved, Investigational Phase 1, Phase 2 97682-44-5, 100286-90-6 60838
39
Everolimus Approved Phase 1, Phase 2 159351-69-6 6442177
40
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2 22916-47-8 4189
41
Sirolimus Approved, Investigational Phase 1, Phase 2 53123-88-9 5284616 6436030 46835353
42
Lenograstim Approved Phase 2,Phase 1 135968-09-1
43 Thiotepa Approved Phase 2,Phase 1 52-24-4 5453
44
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
45
Etoposide Approved Phase 2,Phase 1 33419-42-0 36462
46
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
47
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
48
Gefitinib Approved, Investigational Phase 1, Phase 2 184475-35-2 123631
49
Aldesleukin Approved Phase 2,Phase 1 85898-30-2, 110942-02-4
50
Zoledronic acid Approved Phase 2 118072-93-8 68740

Interventional clinical trials:

(show top 50) (show all 111)

id Name Status NCT ID Phase Drugs
1 Surgery, Radiation Therapy, and Chemotherapy With or Without Photodynamic Therapy in Treating Patients With Newly Diagnosed or Recurrent Malignant Supratentorial Gliomas Unknown status NCT00003788 Phase 3 carmustine;lomustine;porfimer sodium;procarbazine hydrochloride
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma Completed NCT00017147 Phase 3 carmustine;O6-Benzylguanine
4 Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma Completed NCT00052455 Phase 3 lomustine;procarbazine hydrochloride;temozolomide;vincristine sulfate
5 High Light and Low Light Dose PDT in Glioma Completed NCT00118222 Phase 3 porfimer sodium
6 Standard Radiation Therapy, Higher-Dose Radiation Therapy, or Chemotherapy in Treating Older Patients With Glioblastoma Multiforme Completed NCT00820963 Phase 3 temozolomide
7 Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3 Isotretinoin;Procarbazine Hydrochloride
8 Radiation Therapy, Temozolomide, Tamoxifen, and Carboplatin in Treating Patients With Malignant Gliomas Unknown status NCT00492687 Phase 2 carboplatin;tamoxifen citrate;temozolomide
9 Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm Unknown status NCT00009854 Phase 1, Phase 2 carmustine in ethanol
10 Temozolomide in Treating Adults With Newly Diagnosed Primary Malignant Glioblastoma Multiforme Completed NCT00003464 Phase 2 temozolomide
11 Tipifarnib in Treating Patients With Recurrent or Progressive Malignant Glioma Completed NCT00005859 Phase 2 tipifarnib
12 Lapatinib in Treating Patients With Recurrent Glioblastoma Multiforme Completed NCT00099060 Phase 1, Phase 2 lapatinib ditosylate
13 Vaccine Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00643097 Phase 2 Temozolomide
14 Radiation Therapy in Treating Patients With Progressive or Recurrent Malignant Brain Tumors Completed NCT00003574 Phase 2
15 Irinotecan in Treating Patients With Recurrent Malignant Glioma Completed NCT00003301 Phase 1, Phase 2 irinotecan hydrochloride
16 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2 temozolomide
17 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00112736 Phase 1, Phase 2 erlotinib;temsirolimus
18 VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide Completed NCT00369590 Phase 2
19 Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma Completed NCT00008008 Phase 2 cyclophosphamide;thiotepa
20 Immunotoxin Therapy in Treating Patients With Malignant Glioma Completed NCT00006268 Phase 1, Phase 2 isolated perfusion
21 Gimatecan in Treating Patients With Recurrent or Progressive Primary Malignant Glioma Completed NCT00087061 Phase 1, Phase 2 gimatecan
22 SarCNU in Treating Patients With Recurrent Malignant Glioma Completed NCT00036660 Phase 2 SarCNU
23 Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma Completed NCT00045110 Phase 1, Phase 2 erlotinib hydrochloride
24 Thalidomide, Celecoxib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Malignant Glioma Completed NCT00047281 Phase 2 celecoxib;cyclophosphamide;etoposide;thalidomide
25 Efaproxiral Plus Carmustine in Treating Patients With Progressive or Recurrent Malignant Glioma Completed NCT00005855 Phase 1, Phase 2 carmustine;efaproxiral
26 Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) With Bevacizumab and Irinotecan for Malignant Glioma Completed NCT00352521 Phase 2 bevacizumab;irinotecan
27 Temozolomide Plus Irinotecan in Treating Patients With Recurrent Malignant Glioma Completed NCT00006025 Phase 1, Phase 2 irinotecan hydrochloride;temozolomide
28 Temozolomide in Treating Patients With Recurrent Malignant Glioma Completed NCT00004113 Phase 2 temozolomide
29 Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma Completed NCT00010049 Phase 1, Phase 2 imatinib mesylate
30 CCI-779 in Treating Patients With Malignant Glioma Completed NCT00022724 Phase 1, Phase 2 temsirolimus
31 ATN-161 and Carboplatin in Treating Patients With Recurrent Malignant Glioma Completed NCT00352313 Phase 1, Phase 2 ATN-161;carboplatin
32 Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma Completed NCT01462695 Phase 2 Sunitinib Malate
33 Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors Completed NCT00095940 Phase 1, Phase 2 lapatinib ditosylate
34 Chemotherapy in Treating Patients With Progressive or Recurrent Brain Tumors Completed NCT00012038 Phase 1, Phase 2 irofulven
35 Imatinib Mesylate in Treating Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans or Giant Cell Fibroblastoma Completed NCT00085475 Phase 2 imatinib mesylate
36 Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas Completed NCT00042991 Phase 1, Phase 2 gefitinib
37 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
38 Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma Completed NCT00004024 Phase 2
39 Zoledronate in Preventing Osteoporosis in Patients With Primary Malignant Glioma Completed NCT00301873 Phase 2 IV Zometa
40 Suramin in Treating Patients With Recurrent Primary Brain Tumors Completed NCT00002639 Phase 2 chemotherapy;suramin
41 Thalidomide and Procarbazine in Treating Patients With Recurrent or Progressive Malignant Glioma Completed NCT00079092 Phase 2 procarbazine hydrochloride;thalidomide
42 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
43 Bevacizumab and Irinotecan in Treating Patients With Recurrent or Refractory Gliomas Completed NCT00268359 Phase 2 irinotecan hydrochloride
44 Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma Completed NCT00004017 Phase 2
45 Sunitinib in Treating Patients With Recurrent Malignant Gliomas Completed NCT00499473 Phase 2 sunitinib malate
46 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed NCT00025675 Phase 2 gefitinib
47 EMD 121974 in Treating Patients With Progressive or Recurrent Glioma Completed NCT00006093 Phase 1, Phase 2 cilengitide
48 Imaging Procedure Using ALA in Finding Residual Tumor in Grade IV Malignant Astrocytoma Recruiting NCT00752323 Phase 2 aminolevulinic acid
49 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
50 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2 Dasatinib

Search NIH Clinical Center for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

Anatomical Context for Malignant Giant Cell Tumor

MalaCards organs/tissues related to Malignant Giant Cell Tumor:

39
Brain, Bone, Bone Marrow, Liver, Endothelial, T Cells, Uterus

Publications for Malignant Giant Cell Tumor

Articles related to Malignant Giant Cell Tumor:

(show top 50) (show all 63)
id Title Authors Year
1
H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone. ( 28505000 )
2017
2
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report. ( 26951080 )
2016
3
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. ( 26414220 )
2015
4
Treatment and outcome of malignant giant cell tumor in the spine. ( 26040486 )
2015
5
Malignant giant cell tumor of the rib with lung metastasis in a man. ( 25276374 )
2014
6
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. ( 24436827 )
2013
7
Malignant giant cell tumor of the tendon sheath. ( 23981429 )
2013
8
Histological and clinical characteristics of malignant giant cell tumor of bone. ( 22350004 )
2012
9
Secondary malignant giant cell tumor of the clivus: case report. ( 22277296 )
2012
10
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. ( 21237496 )
2011
11
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. ( 21924561 )
2011
12
Primary malignant giant-cell tumor of bone has high survival rate. ( 19902306 )
2010
13
Malignant giant cell tumor of the vulva. ( 19952930 )
2010
14
Malignant giant cell tumor in the posterior fossa of a neonate. ( 20192645 )
2010
15
Fungating primary locally malignant giant cell tumor of ulna: a case report. ( 18552892 )
2008
16
Primary malignant giant cell tumor of bone: a series of three rare cases. ( 17592717 )
2007
17
Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. ( 16205965 )
2006
18
Malignant giant cell tumor of the tendon sheath. ( 14693023 )
2004
19
Malignant giant cell tumor of soft parts. ( 14997349 )
2004
20
Primary de novo malignant giant cell tumor of kidney: a case report. ( 15207006 )
2004
21
Malignant giant cell tumor of the sphenoid. ( 12715335 )
2003
22
Malignant giant cell tumor of soft parts in a mare. ( 14524631 )
2003
23
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. ( 11220389 )
2001
24
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). ( 11079016 )
2000
25
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. ( 10496598 )
1999
26
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). ( 9042281 )
1997
27
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. ( 8319177 )
1993
28
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. ( 8230758 )
1993
29
Significance of chromosomal abnormalities in a malignant giant cell tumor of bone. ( 1756489 )
1991
30
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. ( 2317762 )
1990
31
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. ( 2175663 )
1990
32
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. ( 2554283 )
1989
33
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. ( 2545593 )
1989
34
Malignant giant cell tumor of soft parts presenting as a skin tumor. ( 2658646 )
1989
35
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. ( 3115731 )
1987
36
Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients. ( 3745247 )
1986
37
Malignant giant cell tumor of tendon sheath. Report of a case. ( 2994359 )
1985
38
Malignant giant cell tumor of the frontal bone. ( 6585707 )
1984
39
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. ( 6490003 )
1984
40
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. ( 6465100 )
1984
41
Malignant giant-cell tumor of the distal end of the radius treated by a free vascularized fibular transplant. ( 7240328 )
1981
42
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. ( 7270164 )
1981
43
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. ( 6937839 )
1981
44
Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study. ( 7226022 )
1981
45
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. ( 379085 )
1979
46
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. ( 314048 )
1979
47
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. ( 227563 )
1979
48
Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. ( 212864 )
1978
49
The importance of recognizing malignant giant cell tumor of soft parts. ( 277073 )
1978
50
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. ( 195704 )
1977

Variations for Malignant Giant Cell Tumor

Expression for Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for Malignant Giant Cell Tumor

GO Terms for Malignant Giant Cell Tumor

Cellular components related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 9.16 H3F3A H3F3B
2 nuclear nucleosome GO:0000788 8.96 H3F3A H3F3B
3 Barr body GO:0001740 8.62 H3F3A H3F3B

Biological processes related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.62 H3F3A H3F3B S100B TP53
2 multicellular organism growth GO:0035264 9.59 H3F3A H3F3B
3 regulation of gene silencing by miRNA GO:0060964 9.58 H3F3A H3F3B
4 spermatid development GO:0007286 9.58 H3F3A H3F3B
5 positive regulation of cell growth GO:0030307 9.57 H3F3A H3F3B
6 single fertilization GO:0007338 9.56 H3F3A H3F3B
7 positive regulation of gene expression, epigenetic GO:0045815 9.55 H3F3A H3F3B
8 response to hormone GO:0009725 9.54 H3F3A H3F3B
9 negative regulation of gene expression, epigenetic GO:0045814 9.52 H3F3A H3F3B
10 embryo implantation GO:0007566 9.51 H3F3A H3F3B
11 chromatin silencing at rDNA GO:0000183 9.49 H3F3A H3F3B
12 oogenesis GO:0048477 9.48 H3F3A H3F3B
13 nucleus organization GO:0006997 9.46 H3F3A H3F3B
14 telomere organization GO:0032200 9.43 H3F3A H3F3B
15 DNA replication-independent nucleosome assembly GO:0006336 9.4 H3F3A H3F3B
16 muscle cell differentiation GO:0042692 9.37 H3F3A H3F3B
17 pericentric heterochromatin assembly GO:0031508 9.26 H3F3A H3F3B
18 regulation of centromere complex assembly GO:0090230 9.16 H3F3A H3F3B
19 negative regulation of chromosome condensation GO:1902340 8.96 H3F3A H3F3B
20 telomeric heterochromatin assembly GO:0031509 8.62 H3F3A H3F3B

Molecular functions related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.16 H3F3A H3F3B
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.96 H3F3A H3F3B
3 nucleosomal DNA binding GO:0031492 8.62 H3F3A H3F3B

Sources for Malignant Giant Cell Tumor

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