MCID: MLG067
MIFTS: 35

Malignant Giant Cell Tumor malady

Cancer diseases category

Summaries for Malignant Giant Cell Tumor

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34MalaCards
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MalaCards: Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to giant cell tumor and chondrosarcoma. An important gene associated with Malignant Giant Cell Tumor is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include bone, uterus and kidney.

Aliases & Classifications for Malignant Giant Cell Tumor

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9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant giant cell tumor 9
malignant tumor, giant cell type 9 63
malignant giant cell neoplasm 9


External Ids:

Disease Ontology9 DOID:2705
SNOMED-CT59 83950009
NCIt41 C4090

Related Diseases for Malignant Giant Cell Tumor

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Giant Cell Tumor family:

malignant giant cell tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.5DES, ACTC1, S100B
2chondrosarcoma30.2DES, S100B
3fibrosarcoma30.2ACTC1, DES
4dermatofibrosarcoma protuberans30.2DES, ACTC1, S100B
5leiomyosarcoma30.2S100B, ACTC1, DES
6sarcoma30.2S100B, ACTC1, DES
7malignant giant cell tumor of soft parts10.7
8malignant giant cell tumor of the tendon sheath10.6
9pigmented villonodular synovitis10.4
10villonodular synovitis10.4
11synovitis10.4
12bone giant cell sarcoma10.2
13dermatofibrosarcoma10.2
14bone osteosarcoma10.2
15osteosarcoma10.2
16prostatitis10.2
17fibrous meningioma10.1S100B
18syringoma10.1S100B
19histiocytosis10.1S100B
20ganglioglioma10.1S100B
21fasciitis10.1ACTC1
22infantile myofibromatosis10.1DES
23papilloma10.1ACTC1
24myoepithelioma10.0ACTC1, S100B
25malignant peripheral nerve sheath tumor10.0ACTC1, S100B
26neurofibroma10.0S100B, ACTC1
27adenoid cystic carcinoma10.0ACTC1, S100B
28microphthalmia10.0S100B, ACTC1
29granular cell tumor10.0DES, S100B
30sex cord-gonadal stromal tumor10.0DES, S100B
31glomus tumor10.0DES, ACTC1
32epithelioid leiomyosarcoma10.0DES, ACTC1
33pseudosarcomatous fibromatosis10.0ACTC1, DES
34spindle cell carcinoma10.0ACTC1, DES
35chordoma10.0DES, S100B
36desmoid tumor10.0ACTC1, DES
37adenosarcoma10.0ACTC1, DES
38endometrial stromal sarcoma10.0ACTC1, DES
39rhabdoid tumor10.0ACTC1, DES
40angiomyolipoma10.0ACTC1, DES
41fibroma10.0DES, ACTC1
42synovial sarcoma10.0S100B, DES
43embryonal rhabdomyosarcoma10.0DES, ACTC1
44fibromatosis10.0ACTC1, DES
45abrikosov's tumor10.0DES, ACTC1
46peripheral primitive neuroectodermal tumor10.0S100B, DES
47benign mesothelioma10.0ACTC1, DES
48dilated cardiomyopathy10.0ACTC1, DES
49spindle cell sarcoma10.0S100B, ACTC1, DES
50cutaneous fibrous histiocytoma10.0S100B, ACTC1, DES

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to malignant giant cell tumor

Symptoms for Malignant Giant Cell Tumor

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Drugs & Therapeutics for Malignant Giant Cell Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Malignant Giant Cell Tumor

Search CenterWatch for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

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Anatomical Context for Malignant Giant Cell Tumor

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34MalaCards
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MalaCards organs/tissues related to Malignant Giant Cell Tumor:

34
Bone, Uterus, Kidney, Skin, Prostate

Animal Models for Malignant Giant Cell Tumor or affiliated genes

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Publications for Malignant Giant Cell Tumor

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53PubMed
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Articles related to Malignant Giant Cell Tumor:

(show top 50)    (show all 58)
idTitleAuthorsYear
1
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. (24436827)
2013
2
Malignant giant cell tumor of the tendon sheath. (23981429)
2013
3
Histological and clinical characteristics of malignant giant cell tumor of bone. (22350004)
2012
4
Secondary malignant giant cell tumor of the clivus: case report. (22277296)
2012
5
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. (21924561)
2011
6
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. (21237496)
2011
7
Malignant giant cell tumor of the vulva. (19952930)
2010
8
Primary malignant giant-cell tumor of bone has high survival rate. (19902306)
2010
9
Fungating primary locally malignant giant cell tumor of ulna: a case report. (18552892)
2008
10
Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. (16205965)
2006
11
Primary de novo malignant giant cell tumor of kidney: a case report. (15207006)
2004
12
Malignant giant cell tumor of the tendon sheath. (14693023)
2004
13
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
14
Malignant giant cell tumor of the sphenoid. (12715335)
2003
15
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. (11220389)
2001
16
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). (11079016)
2000
17
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). (9042281)
1997
18
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. (8230758)
1993
19
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. (8319177)
1993
20
Significance of chromosomal abnormalities in a malignant giant cell tumor of bone. (1756489)
1991
21
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. (2317762)
1990
22
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. (2175663)
1990
23
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. (2554283)
1989
24
Malignant giant cell tumor of soft parts presenting as a skin tumor. (2658646)
1989
25
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. (2545593)
1989
26
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. (3115731)
1987
27
Malignant giant cell tumor of tendon sheath. Report of a case. (2994359)
1985
28
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. (6490003)
1984
29
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
30
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. (6937839)
1981
31
Malignant giant-cell tumor of the distal end of the radius treated by a free vascularized fibular transplant. (7240328)
1981
32
Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study. (7226022)
1981
33
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. (7270164)
1981
34
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. (227563)
1979
35
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. (314048)
1979
36
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. (379085)
1979
37
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
38
Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. (212864)
1978
39
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
40
Malignant giant cell tumor in a dog. (914686)
1977
41
Feline malignant giant cell tumor of bone associated with C-type virus particles. (185002)
1976
42
Malignant giant cell tumor of the tendon sheath. Ultrastructural study and review of the literature. (4346849)
1973
43
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972
44
Malignant giant cell tumor of the sphenoid bone and its differential diagnosis. (5410307)
1970
45
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). (5272232)
1970
46
Malignant giant cell tumor of the mandible: report of case. (13665456)
1959
47
Case report; malignant giant cell tumor. (13620562)
1959
48
Malignant giant-cell tumor of the ulna; report of a case of eighteen years' duration. (13587583)
1958
49
Malignant giant cell tumor of bone. (13272874)
1955
50
Malignant giant cell tumor of bone. (19970407)
1938

Variations for Malignant Giant Cell Tumor

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Expression for genes affiliated with Malignant Giant Cell Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor

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Pathways for genes affiliated with Malignant Giant Cell Tumor

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Sources:
51PathCards, 5Cell Signaling Technology, 31KEGG, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ACTC1, DES
2
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.0ACTC1, DES
3
Show member pathways
9.0ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor

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Sources:
46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.5DES, S100B
2ccl446 3010.4S100B, DES
3bromodeoxyuridine469.3S100B, DES
4procollagen469.3ACTC1, DES
5methionine469.2S100B, DES
6biotin46 25 1211.2ACTC1, DES
7ethanol46 52 25 1212.2DES, S100B
8norepinephrine46 25 1211.1S100B, DES
9proline469.1S100B, DES
10acetylcholine46 52 30 25 1213.0S100B, DES
11orcein468.9S100B, ACTC1, DES
12s 100468.9DES, ACTC1, S100B
13reticulin468.9S100B, ACTC1, DES
14mucicarmine468.9DES, ACTC1, S100B
15b 723468.9S100B, ACTC1, DES
16hematoxylin468.9DES, ACTC1, S100B
17formaldehyde46 259.9S100B, ACTC1, DES
18imatinib46 52 1210.9DES, ACTC1, S100B
19glycogen46 259.9S100B, ACTC1, DES
20paraffin468.9DES, ACTC1, S100B
21iron46 259.9S100B, ACTC1, DES
22creatinine468.9DES, ACTC1, S100B
23progesterone46 30 62 25 1212.8S100B, ACTC1, DES
24testosterone46 62 25 1211.8S100B, ACTC1, DES
25steroid468.8S100B, ACTC1, DES
26vegf468.8DES, ACTC1, S100B
27oxygen46 259.8DES, ACTC1, S100B
28estrogen468.8DES, ACTC1, S100B
29retinoic acid46 259.7S100B, ACTC1, DES
30glucose468.7DES, ACTC1, S100B
31tyrosine468.7DES, ACTC1, S100B
32calcium46 52 25 1211.2DES, ACTC1, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor

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17Gene Ontology
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Biological processes related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.0ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor

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Sources for Malignant Giant Cell Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet