MCID: MLG067
MIFTS: 36

Malignant Giant Cell Tumor malady

Cancer diseases category
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Summaries for Malignant Giant Cell Tumor

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MalaCards based summary: Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to giant cell tumor and chondrosarcoma. An important gene associated with Malignant Giant Cell Tumor is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include bone, uterus and kidney.

Aliases & Classifications for Malignant Giant Cell Tumor

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Malignant Giant Cell Tumor, Aliases & Descriptions:

Name: Malignant Giant Cell Tumor 8
Malignant Tumor, Giant Cell Type 8 62
 
Malignant Giant Cell Neoplasm 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:2705
SNOMED-CT57 83950009
NCIt39 C4090

Related Diseases for Malignant Giant Cell Tumor

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Diseases in the Giant Cell Tumor family:

malignant giant cell tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.3DES, ACTC1, S100B
2chondrosarcoma30.1DES, S100B
3fibrosarcoma30.0ACTC1, DES
4dermatofibrosarcoma protuberans30.0DES, ACTC1, S100B
5leiomyosarcoma30.0S100B, ACTC1, DES
6sarcoma29.9S100B, ACTC1, DES
7malignant giant cell tumor of soft parts10.7
8malignant giant cell tumor of the tendon sheath10.6
9pigmented villonodular synovitis10.4
10villonodular synovitis10.4
11synovitis10.4
12fibrous meningioma10.4S100B
13syringoma10.4S100B
14histiocytosis10.4S100B
15ganglioglioma10.4S100B
16fasciitis10.4ACTC1
17infantile myofibromatosis10.3DES
18papilloma10.3ACTC1
19bone giant cell sarcoma10.2
20bone osteosarcoma10.2
21osteosarcoma10.2
22prostatitis10.2
23myoepithelioma10.1ACTC1, S100B
24malignant peripheral nerve sheath tumor10.1ACTC1, S100B
25neurofibroma10.1S100B, ACTC1
26salivary gland adenoid cystic carcinoma10.1ACTC1, S100B
27microphthalmia10.1S100B, ACTC1
28granular cell tumor10.0DES, S100B
29sex cord-gonadal stromal tumor10.0DES, S100B
30paraganglioma10.0DES, ACTC1
31epithelioid leiomyosarcoma10.0DES, ACTC1
32pseudosarcomatous fibromatosis10.0ACTC1, DES
33spindle cell carcinoma10.0ACTC1, DES
34chordoma10.0DES, S100B
35desmoid tumor10.0ACTC1, DES
36adenosarcoma10.0ACTC1, DES
37endometrial stromal sarcoma10.0ACTC1, DES
38rhabdoid tumor10.0ACTC1, DES
39angiomyolipoma10.0ACTC1, DES
40fibroma10.0DES, ACTC1
41synovial sarcoma10.0S100B, DES
42embryonal rhabdomyosarcoma10.0DES, ACTC1
43fibromatosis10.0ACTC1, DES
44abrikosov's tumor10.0DES, ACTC1
45peripheral primitive neuroectodermal tumor9.9S100B, DES
46malignant mesothelioma9.9ACTC1, DES
47dilated cardiomyopathy9.8ACTC1, DES
48spindle cell sarcoma9.8S100B, ACTC1, DES
49cutaneous fibrous histiocytoma9.8S100B, ACTC1, DES
50fibrous histiocytoma9.8DES, ACTC1, S100B

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to malignant giant cell tumor

Symptoms for Malignant Giant Cell Tumor

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Drugs & Therapeutics for Malignant Giant Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Malignant Giant Cell Tumor

Search NIH Clinical Center for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

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Anatomical Context for Malignant Giant Cell Tumor

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MalaCards organs/tissues related to Malignant Giant Cell Tumor:

32
Bone, Uterus, Kidney, Lung, Skin, Prostate

Animal Models for Malignant Giant Cell Tumor or affiliated genes

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Publications for Malignant Giant Cell Tumor

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Articles related to Malignant Giant Cell Tumor:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Malignant giant cell tumor of the rib with lung metastasis in a man. (25276374)
2014
2
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. (24436827)
2013
3
Malignant giant cell tumor of the tendon sheath. (23981429)
2013
4
Histological and clinical characteristics of malignant giant cell tumor of bone. (22350004)
2012
5
Secondary malignant giant cell tumor of the clivus: case report. (22277296)
2012
6
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. (21924561)
2011
7
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. (21237496)
2011
8
Malignant giant cell tumor of the vulva. (19952930)
2010
9
Primary malignant giant-cell tumor of bone has high survival rate. (19902306)
2010
10
Fungating primary locally malignant giant cell tumor of ulna: a case report. (18552892)
2008
11
Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. (16205965)
2006
12
Primary de novo malignant giant cell tumor of kidney: a case report. (15207006)
2004
13
Malignant giant cell tumor of the tendon sheath. (14693023)
2004
14
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
15
Malignant giant cell tumor of the sphenoid. (12715335)
2003
16
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. (11220389)
2001
17
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). (11079016)
2000
18
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). (9042281)
1997
19
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. (8230758)
1993
20
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. (8319177)
1993
21
Significance of chromosomal abnormalities in a malignant giant cell tumor of bone. (1756489)
1991
22
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. (2317762)
1990
23
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. (2175663)
1990
24
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. (2554283)
1989
25
Malignant giant cell tumor of soft parts presenting as a skin tumor. (2658646)
1989
26
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. (2545593)
1989
27
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. (3115731)
1987
28
Malignant giant cell tumor of tendon sheath. Report of a case. (2994359)
1985
29
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. (6490003)
1984
30
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
31
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. (6937839)
1981
32
Malignant giant-cell tumor of the distal end of the radius treated by a free vascularized fibular transplant. (7240328)
1981
33
Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study. (7226022)
1981
34
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. (7270164)
1981
35
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. (227563)
1979
36
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. (314048)
1979
37
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. (379085)
1979
38
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
39
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
40
Malignant giant cell tumor in a dog. (914686)
1977
41
Feline malignant giant cell tumor of bone associated with C-type virus particles. (185002)
1976
42
Malignant giant cell tumor of the tendon sheath. Ultrastructural study and review of the literature. (4346849)
1973
43
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972
44
Malignant giant cell tumor of the sphenoid bone and its differential diagnosis. (5410307)
1970
45
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). (5272232)
1970
46
Malignant giant cell tumor of the mandible: report of case. (13665456)
1959
47
Case report; malignant giant cell tumor. (13620562)
1959
48
Malignant giant-cell tumor of the ulna; report of a case of eighteen years' duration. (13587583)
1958
49
Malignant giant cell tumor of bone. (13272874)
1955
50
Malignant giant cell tumor of bone. (19970407)
1938

Variations for Malignant Giant Cell Tumor

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Expression for genes affiliated with Malignant Giant Cell Tumor

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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for genes affiliated with Malignant Giant Cell Tumor

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Pathways related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ACTC1, DES
2
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.0ACTC1, DES
3
Show member pathways
9.0ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor

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Compounds related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.5DES, S100B
2ccl444 2810.4S100B, DES
3bromodeoxyuridine449.3S100B, DES
4procollagen449.3ACTC1, DES
5methionine449.2S100B, DES
6biotin44 24 1111.2ACTC1, DES
7ethanol44 50 24 1112.2DES, S100B
8norepinephrine44 24 1111.1S100B, DES
9proline449.1S100B, DES
10acetylcholine44 50 28 24 1113.0S100B, DES
11orcein448.9S100B, ACTC1, DES
12s 100448.9DES, ACTC1, S100B
13reticulin448.9S100B, ACTC1, DES
14mucicarmine448.9DES, ACTC1, S100B
15b 723448.9S100B, ACTC1, DES
16hematoxylin448.9DES, ACTC1, S100B
17formaldehyde44 249.9S100B, ACTC1, DES
18imatinib44 50 1110.9DES, ACTC1, S100B
19glycogen44 249.9S100B, ACTC1, DES
20paraffin448.9DES, ACTC1, S100B
21iron44 249.9S100B, ACTC1, DES
22creatinine448.9DES, ACTC1, S100B
23progesterone44 28 61 24 1112.8S100B, ACTC1, DES
24testosterone44 61 24 1111.8S100B, ACTC1, DES
25steroid448.8S100B, ACTC1, DES
26vegf448.8DES, ACTC1, S100B
27oxygen44 249.8DES, ACTC1, S100B
28estrogen448.8DES, ACTC1, S100B
29retinoic acid44 249.7S100B, ACTC1, DES
30glucose448.7DES, ACTC1, S100B
31tyrosine448.7DES, ACTC1, S100B
32calcium44 50 24 1111.2DES, ACTC1, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor

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Biological processes related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.0ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor

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Sources for Malignant Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet