MCID: MLG067
MIFTS: 39

Malignant Giant Cell Tumor malady

Categories: Cancer diseases

Aliases & Classifications for Malignant Giant Cell Tumor

Aliases & Descriptions for Malignant Giant Cell Tumor:

Name: Malignant Giant Cell Tumor 12 14
Malignant Tumor, Giant Cell Type 12 69
Malignant Giant Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2705
NCIt 47 C4090
SNOMED-CT 64 83950009
UMLS 69 C0334229

Summaries for Malignant Giant Cell Tumor

MalaCards based summary : Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to malignant giant cell tumor of the tendon sheath and pigmented villonodular synovitis. An important gene associated with Malignant Giant Cell Tumor is ACTC1 (Actin, Alpha, Cardiac Muscle 1), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Transcriptional misregulation in cancer. The drugs Carmustine and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include bone, uterus and lung, and related phenotype is normal.

Related Diseases for Malignant Giant Cell Tumor

Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
id Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor of the tendon sheath 33.4 CD68 PTPRC
2 pigmented villonodular synovitis 30.0 CD68 LYZ
3 malignant giant cell tumor of soft parts 12.2
4 bone giant cell sarcoma 11.0
5 giant cell tumor 10.5
6 acute generalized exanthematous pustulosis 10.3 ACTC1 S100B
7 myoma 10.3 ACTC1 S100B
8 spleen angiosarcoma 10.3 ACTC1 S100B
9 pericardium leiomyoma 10.3 ACTC1 TP53
10 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.3 ACTC1 S100B
11 mediastinum liposarcoma 10.3 ACTC1 S100B
12 dyslexia 10.3 ACTC1 S100B
13 porokeratosis 10.3 S100B TP53
14 paraphimosis 10.3 ACTC1 TP53
15 bone deterioration disease 10.3 S100B TP53
16 coronary stenosis 10.3 ACTC1 TP53
17 central nervous system mature teratoma 10.3 S100B TP53
18 cavernous sinus meningioma 10.3 LYZ S100B
19 house allergic alveolitis 10.2 ACTC1 TP53
20 glomangioma 10.2 ACTC1 TP53
21 developmental coordination disorder 10.2 ACP5 PTPRC
22 growth retardation hydrocephaly lung hypoplasia 10.2 ACTC1 TP53
23 plasmodium ovale malaria 10.2 ACTC1 TP53
24 omodysplasia 2 10.2 ACTC1 PTPRC
25 primary hyperoxaluria 10.2 LYZ TP53
26 diarrhea, chronic, with villous atrophy 10.2 ACTC1 S100B
27 adenosquamous colon carcinoma 10.2 LYZ PTPRC
28 vascular myelopathy 10.2 S100B TP53
29 ampulla of vater mucinous adenocarcinoma 10.2 PTPRC S100B
30 spinal cord intramedullary teratoma 10.2 PTPRC TP53
31 enchondromatosis dwarfism deafness 10.2 S100B TP53
32 lung benign neoplasm 10.2 ACTC1 PTPRC
33 episodic ataxia 10.2 ACTC1 CD68
34 conjunctival cancer 10.2 ACTC1 S100B TP53
35 neutrophil immunodeficiency syndrome 10.2 ACTC1 S100B TP53
36 linitis plastica 10.2 CD68 TP53
37 mediastinum angiosarcoma 10.2 ACTC1 S100B TP53
38 cecum adenoma 10.2 ACTC1 S100B TP53
39 adenosarcoma 10.2 ACTC1 S100B TP53
40 occlusion precerebral artery 10.2 ACTC1 S100B TP53
41 childhood brain germinoma 10.2 S100B TP53
42 juvenile astrocytoma 10.2 ACTC1 S100B TP53
43 linear porokeratosis 10.2 ACTC1 CD68
44 gastrointestinal stromal tumor 10.2 ACTC1 S100B TP53
45 demyelinating disease 10.1 CD68 LYZ
46 maxillary sinus squamous cell carcinoma 10.1 CD68 LYZ
47 anal carcinoma in situ 10.1 CD68 TP53
48 skin glomus tumor 10.1 CD68 S100B
49 tinea favosa 10.1 ACTC1 CD68
50 pediculus humanus corporis infestation 10.1 CD68 S100B

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to Malignant Giant Cell Tumor

Symptoms & Phenotypes for Malignant Giant Cell Tumor

MGI Mouse Phenotypes related to Malignant Giant Cell Tumor:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 ACTC1 H3F3B LYZ PTPRC S100B TP53

Drugs & Therapeutics for Malignant Giant Cell Tumor

Drugs for Malignant Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 201)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carmustine Approved Phase 3,Phase 1,Phase 2 154-93-8 2578
2
Lomustine Approved Phase 3 13010-47-4 3950
3
Procarbazine Approved Phase 3,Phase 2 671-16-9 4915
4
Trioxsalen Approved Phase 3 3902-71-4 5585
5
Dacarbazine Approved, Investigational Phase 3,Phase 2,Phase 1 4342-03-4 5351166
6
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1 85622-93-1 5394
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
8
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
9
Methylphenidate Approved, Investigational Phase 3 113-45-1 4158
10
Morphine Approved, Investigational Phase 3 57-27-2 5288826
11
Cyproheptadine Approved Phase 3 129-03-3 2913
12
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
13
Isotretinoin Approved Phase 3,Phase 1 4759-48-2 5538 5282379
14
Tretinoin Approved, Investigational, Nutraceutical Phase 3,Phase 1 302-79-4 5538
15 Alkylating Agents Phase 3,Phase 2,Phase 1
16 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
17 Dermatologic Agents Phase 3,Phase 2,Phase 1
18 Dihematoporphyrin Ether Phase 3
19 Ether Phase 3
20 Photosensitizing Agents Phase 3,Phase 2,Phase 1
21 Analgesics Phase 3,Phase 2,Phase 1
22 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
23 Liver Extracts Phase 3,Phase 2,Phase 1
24 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
26 Adjuvants, Anesthesia Phase 3
27 Analgesics, Opioid Phase 3
28 Anesthetics Phase 3
29 Anesthetics, General Phase 3
30 Anesthetics, Intravenous Phase 3
31 Narcotics Phase 3
32 pancreatic polypeptide Phase 3,Phase 1
33 O(6)-benzylguanine Phase 3,Phase 1
34 Antimitotic Agents Phase 3,Phase 1,Phase 2
35 Anesthetics, Inhalation Phase 3
36 Hematoporphyrin Derivative Phase 3
37 Hematoporphyrins Phase 3
38 Epoetin alfa Phase 3 113427-24-0
39 Gastrointestinal Agents Phase 3,Phase 1
40 Neurotransmitter Agents Phase 3
41 Anti-Allergic Agents Phase 3
42 Antipruritics Phase 3
43 Histamine Antagonists Phase 3
44 Histamine H1 Antagonists Phase 3
45
Histamine Phosphate Phase 3 51-74-1 65513
46
Serotonin Phase 3 50-67-9 5202
47 Serotonin Agents Phase 3
48 Serotonin Antagonists Phase 3
49 Cola Nutraceutical Phase 3
50
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 498142 38904

Interventional clinical trials:

(show top 50) (show all 125)
id Name Status NCT ID Phase
1 Surgery, Radiation Therapy, and Chemotherapy With or Without Photodynamic Therapy in Treating Patients With Newly Diagnosed or Recurrent Malignant Supratentorial Gliomas Unknown status NCT00003788 Phase 3
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
3 S0001 RT and Carmustine With or Without O6BG in Patients With New Glioblastoma Multiforme or Gliosarcoma Completed NCT00017147 Phase 3
4 Temozolomide Compared to Procarbazine, Lomustine, and Vincristine in Treating Patients With Recurrent Malignant Glioma Completed NCT00052455 Phase 3
5 High Light and Low Light Dose PDT in Glioma Completed NCT00118222 Phase 3
6 Standard Radiation Therapy, Higher-Dose Radiation Therapy, or Chemotherapy in Treating Older Patients With Glioblastoma Multiforme Completed NCT00820963 Phase 3
7 E-MOSAIC Electronic Tool to Monitor Symptoms Completed NCT00477919 Phase 3
8 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
9 Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas Withdrawn NCT00003564 Phase 3
10 Radiation Therapy, Temozolomide, Tamoxifen, and Carboplatin in Treating Patients With Malignant Gliomas Unknown status NCT00492687 Phase 2
11 Carmustine Followed By Surgery in Treating Patients With Recurrent Supratentorial Malignant Glioma or Metastatic Brain Neoplasm Unknown status NCT00009854 Phase 1, Phase 2
12 Thalidomide, Celecoxib, and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Malignant Glioma Unknown status NCT00047281 Phase 2
13 Erlotinib in Treating Patients With Recurrent Malignant Glioma or Recurrent or Progressive Meningioma Unknown status NCT00045110 Phase 1, Phase 2
14 Temozolomide in Treating Adults With Newly Diagnosed Primary Malignant Glioblastoma Multiforme Completed NCT00003464 Phase 2
15 Tipifarnib in Treating Patients With Recurrent or Progressive Malignant Glioma Completed NCT00005859 Phase 2
16 Lapatinib in Treating Patients With Recurrent Glioblastoma Multiforme Completed NCT00099060 Phase 1, Phase 2
17 Vaccine Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT00643097 Phase 2
18 Radiation Therapy in Treating Patients With Progressive or Recurrent Malignant Brain Tumors Completed NCT00003574 Phase 2
19 Irinotecan in Treating Patients With Recurrent Malignant Glioma Completed NCT00003301 Phase 1, Phase 2
20 Temozolomide in Treating Patients With Recurrent Glioblastoma Multiforme or Other Malignant Glioma Completed NCT00498927 Phase 2
21 Erlotinib and Temsirolimus in Treating Patients With Recurrent Malignant Glioma Completed NCT00112736 Phase 1, Phase 2
22 VEGF Trap in Treating Patients With Recurrent Malignant Gliomas That Did Not Respond to Temozolomide Completed NCT00369590 Phase 2
23 Thiotepa Followed by Peripheral Stem Cell or Bone Marrow Transplant in Treating Patients With Malignant Glioma Completed NCT00008008 Phase 2
24 Immunotoxin Therapy in Treating Patients With Malignant Glioma Completed NCT00006268 Phase 1, Phase 2
25 Gimatecan in Treating Patients With Recurrent or Progressive Primary Malignant Glioma Completed NCT00087061 Phase 1, Phase 2
26 SarCNU in Treating Patients With Recurrent Malignant Glioma Completed NCT00036660 Phase 2
27 Efaproxiral Plus Carmustine in Treating Patients With Progressive or Recurrent Malignant Glioma Completed NCT00005855 Phase 1, Phase 2
28 Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) With Bevacizumab and Irinotecan for Malignant Glioma Completed NCT00352521 Phase 2
29 Temozolomide Plus Irinotecan in Treating Patients With Recurrent Malignant Glioma Completed NCT00006025 Phase 1, Phase 2
30 Temozolomide in Treating Patients With Recurrent Malignant Glioma Completed NCT00004113 Phase 2
31 Imatinib Mesylate in Treating Patients With Recurrent Malignant Glioma or Meningioma Completed NCT00010049 Phase 1, Phase 2
32 CCI-779 in Treating Patients With Malignant Glioma Completed NCT00022724 Phase 1, Phase 2
33 ATN-161 and Carboplatin in Treating Patients With Recurrent Malignant Glioma Completed NCT00352313 Phase 1, Phase 2
34 Sunitinib Malate in Treating Younger Patients With Recurrent, Refractory, or Progressive Malignant Glioma or Ependymoma Completed NCT01462695 Phase 2
35 Lapatinib in Treating Young Patients With Recurrent or Refractory Central Nervous System Tumors Completed NCT00095940 Phase 1, Phase 2
36 Chemotherapy in Treating Patients With Progressive or Recurrent Brain Tumors Completed NCT00012038 Phase 1, Phase 2
37 Imatinib Mesylate in Treating Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans or Giant Cell Fibroblastoma Completed NCT00085475 Phase 2
38 Gefitinib and Radiation Therapy in Treating Children With Newly Diagnosed Gliomas Completed NCT00042991 Phase 1, Phase 2
39 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003478 Phase 1, Phase 2
40 Biological Therapy Following Surgery and Radiation Therapy in Treating Patients With Primary or Recurrent Astrocytoma or Oligodendroglioma Completed NCT00004024 Phase 2
41 Zoledronate in Preventing Osteoporosis in Patients With Primary Malignant Glioma Completed NCT00301873 Phase 2
42 Suramin in Treating Patients With Recurrent Primary Brain Tumors Completed NCT00002639 Phase 2
43 Thalidomide and Procarbazine in Treating Patients With Recurrent or Progressive Malignant Glioma Completed NCT00079092 Phase 2
44 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Cancers Completed NCT00002752 Phase 1, Phase 2
45 Bevacizumab and Irinotecan in Treating Patients With Recurrent or Refractory Gliomas Completed NCT00268359 Phase 2
46 Radiolabeled Monoclonal Antibody in Treating Patients With Glioblastoma Multiforme or Anaplastic Astrocytoma Completed NCT00004017 Phase 2
47 Sunitinib in Treating Patients With Recurrent Malignant Gliomas Completed NCT00499473 Phase 2
48 Gefitinib in Treating Patients With Recurrent or Progressive CNS Tumors Completed NCT00025675 Phase 2
49 EMD 121974 in Treating Patients With Progressive or Recurrent Glioma Completed NCT00006093 Phase 1, Phase 2
50 Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors Completed NCT00002608 Phase 2

Search NIH Clinical Center for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

Anatomical Context for Malignant Giant Cell Tumor

MalaCards organs/tissues related to Malignant Giant Cell Tumor:

39
Bone, Uterus, Lung, Skin, Kidney, Prostate

Publications for Malignant Giant Cell Tumor

Articles related to Malignant Giant Cell Tumor:

(show top 50) (show all 62)
id Title Authors Year
1
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report. ( 26951080 )
2016
2
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. ( 26414220 )
2015
3
Treatment and outcome of malignant giant cell tumor in the spine. ( 26040486 )
2015
4
Malignant giant cell tumor of the rib with lung metastasis in a man. ( 25276374 )
2014
5
Malignant giant cell tumor of the tendon sheath. ( 23981429 )
2013
6
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. ( 24436827 )
2013
7
Secondary malignant giant cell tumor of the clivus: case report. ( 22277296 )
2012
8
Histological and clinical characteristics of malignant giant cell tumor of bone. ( 22350004 )
2012
9
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. ( 21924561 )
2011
10
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. ( 21237496 )
2011
11
Primary malignant giant-cell tumor of bone has high survival rate. ( 19902306 )
2010
12
Malignant giant cell tumor in the posterior fossa of a neonate. ( 20192645 )
2010
13
Malignant giant cell tumor of the vulva. ( 19952930 )
2010
14
Fungating primary locally malignant giant cell tumor of ulna: a case report. ( 18552892 )
2008
15
Primary malignant giant cell tumor of bone: a series of three rare cases. ( 17592717 )
2007
16
Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. ( 16205965 )
2006
17
Malignant giant cell tumor of soft parts. ( 14997349 )
2004
18
Primary de novo malignant giant cell tumor of kidney: a case report. ( 15207006 )
2004
19
Malignant giant cell tumor of the tendon sheath. ( 14693023 )
2004
20
Malignant giant cell tumor of the sphenoid. ( 12715335 )
2003
21
Malignant giant cell tumor of soft parts in a mare. ( 14524631 )
2003
22
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. ( 11220389 )
2001
23
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). ( 11079016 )
2000
24
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. ( 10496598 )
1999
25
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). ( 9042281 )
1997
26
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. ( 8230758 )
1993
27
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. ( 8319177 )
1993
28
Significance of chromosomal abnormalities in a malignant giant cell tumor of bone. ( 1756489 )
1991
29
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. ( 2175663 )
1990
30
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. ( 2317762 )
1990
31
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. ( 2545593 )
1989
32
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. ( 2554283 )
1989
33
Malignant giant cell tumor of soft parts presenting as a skin tumor. ( 2658646 )
1989
34
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. ( 3115731 )
1987
35
Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients. ( 3745247 )
1986
36
Malignant giant cell tumor of tendon sheath. Report of a case. ( 2994359 )
1985
37
Malignant giant cell tumor of the frontal bone. ( 6585707 )
1984
38
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. ( 6490003 )
1984
39
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. ( 6465100 )
1984
40
Malignant giant-cell tumor of the distal end of the radius treated by a free vascularized fibular transplant. ( 7240328 )
1981
41
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. ( 6937839 )
1981
42
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. ( 7270164 )
1981
43
Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study. ( 7226022 )
1981
44
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. ( 314048 )
1979
45
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. ( 379085 )
1979
46
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. ( 227563 )
1979
47
The importance of recognizing malignant giant cell tumor of soft parts. ( 277073 )
1978
48
Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. ( 212864 )
1978
49
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. ( 195704 )
1977
50
Malignant giant cell tumor in a dog. ( 914686 )
1977

Variations for Malignant Giant Cell Tumor

Expression for Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for Malignant Giant Cell Tumor

GO Terms for Malignant Giant Cell Tumor

Cellular components related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.5 ACP5 ACTC1 H3F3A H3F3B LYZ PTPRC
2 nuclear chromosome GO:0000228 9.26 H3F3A H3F3B
3 nuclear nucleosome GO:0000788 9.16 H3F3A H3F3B
4 Barr body GO:0001740 8.62 H3F3A H3F3B

Biological processes related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.69 H3F3A H3F3B LYZ
2 cell proliferation GO:0008283 9.62 H3F3A H3F3B S100B TP53
3 negative regulation of gene expression, epigenetic GO:0045814 9.55 H3F3A H3F3B
4 embryo implantation GO:0007566 9.54 H3F3A H3F3B
5 chromatin silencing at rDNA GO:0000183 9.52 H3F3A H3F3B
6 response to gamma radiation GO:0010332 9.49 PTPRC TP53
7 oogenesis GO:0048477 9.48 H3F3A H3F3B
8 telomere organization GO:0032200 9.46 H3F3A H3F3B
9 nucleus organization GO:0006997 9.43 H3F3A H3F3B
10 DNA replication-independent nucleosome assembly GO:0006336 9.4 H3F3A H3F3B
11 muscle cell differentiation GO:0042692 9.37 H3F3A H3F3B
12 pericentric heterochromatin assembly GO:0031508 9.26 H3F3A H3F3B
13 regulation of centromere complex assembly GO:0090230 9.16 H3F3A H3F3B
14 negative regulation of chromosome condensation GO:1902340 8.96 H3F3A H3F3B
15 telomeric heterochromatin assembly GO:0031509 8.62 H3F3A H3F3B

Molecular functions related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.62 H3F3A H3F3B

Sources for Malignant Giant Cell Tumor

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