MCID: MLG067
MIFTS: 34

Malignant Giant Cell Tumor malady

Cancer diseases category

Summaries for Malignant Giant Cell Tumor

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32MalaCards
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MalaCards: Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to giant cell tumor and chondrosarcoma. An important gene associated with Malignant Giant Cell Tumor is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds procollagen and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide have been mentioned in the context of this disorder. Affiliated tissues include bone, uterus and spinal cord.

Aliases & Classifications for Malignant Giant Cell Tumor

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant giant cell tumor 8
malignant tumor, giant cell type 8 60
malignant giant cell neoplasm 8


External Ids:

Disease Ontology8 DOID:2705
SNOMED-CT56 83950009
NCIt39 C4090

Related Diseases for Malignant Giant Cell Tumor

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Giant Cell Tumor family:

malignant giant cell tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.5S100B, DES, ACTC1
2chondrosarcoma30.2S100B, DES
3leiomyosarcoma30.1ACTC1, DES, S100B
4sarcoma30.1ACTC1, DES, S100B
5bone giant cell tumor10.8
6malignant giant cell tumor of soft parts10.7
7malignant giant cell tumor of the tendon sheath10.6
8pigmented villonodular synovitis10.4
9villonodular synovitis10.4
10synovitis10.4
11bone giant cell sarcoma10.3
12dermatofibrosarcoma10.1
13bone osteosarcoma10.1
14fibrosarcoma10.1
15osteosarcoma10.1
16prostatitis10.1
17uterus leiomyosarcoma10.1
18lymphangioleiomyomatosis10.0DES
19infantile myofibromatosis10.0DES
20fasciitis10.0ACTC1
21angiosarcoma10.0ACTC1
22lipoma10.0DES
23liposarcoma10.0DES
24fibrous meningioma10.0S100B
25teratoma10.0ACTC1
26adenoma10.0ACTC1
27syringoma10.0S100B
28perineurioma10.0S100B
29ganglioglioma10.0S100B
30hemangioblastoma10.0S100B
31meningioma10.0S100B
32paraganglioma10.0S100B
33histiocytosis10.0S100B
34hemangioma10.0ACTC1
35hypertrophic cardiomyopathy10.0ACTC1
36glomus tumor10.0ACTC1, DES
37angiomyolipoma10.0DES, ACTC1
38rhabdoid tumor10.0DES, ACTC1
39epithelioid leiomyosarcoma10.0DES, ACTC1
40pseudosarcomatous fibromatosis10.0DES, ACTC1
41spindle cell carcinoma10.0DES, ACTC1
42adenosarcoma10.0DES, ACTC1
43endometrial stromal sarcoma10.0DES, ACTC1
44embryonal rhabdomyosarcoma10.0ACTC1, DES
45abrikosov's tumor10.0DES, ACTC1
46desmoid tumor10.0ACTC1, DES
47benign mesothelioma10.0DES, ACTC1
48fibromatosis10.0DES, ACTC1
49tuberous sclerosis10.0S100B
50papilloma10.0ACTC1

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to malignant giant cell tumor

Clinical Features for Malignant Giant Cell Tumor

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Drugs & Therapeutics for Malignant Giant Cell Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Giant Cell Tumor

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Anatomical Context for Malignant Giant Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Malignant Giant Cell Tumor:

32
Bone, Uterus, Spinal cord, Kidney, Skin, Prostate

Animal Models for Malignant Giant Cell Tumor or affiliated genes

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Publications for Malignant Giant Cell Tumor

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50PubMed
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Articles related to Malignant Giant Cell Tumor:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Triple-phase dynamic MRI: A new clue to predict malignant transformation of giant cell tumor of bone. (24239410)
2014
2
Partial response of a rare malignant metastatic diffuse tenosynovial giant cell tumor with benign histologic features, treated with SCH 717-454, an insulin growth factor receptor inhibitor, in combination with everolimus, an MTOR inhibitor. (23430345)
2013
3
Giant cell tumor of the larynx: a case of malignant sarcomatous transformation. (23780608)
2013
4
Giant cell tumor of the distal common bile duct: report of a rare, benign entity that may mimic malignant biliary obstruction. (24287577)
2013
5
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. (24436827)
2013
6
p53 mutations may be involved in malignant transformation of giant cell tumor of bone through interaction with GPX1. (23748877)
2013
7
Malignant giant cell tumor of the tendon sheath. (23981429)
2013
8
Cytogenetic study of secondary malignancy in giant cell tumor. (23929353)
2013
9
Histological and clinical characteristics of malignant giant cell tumor of bone. (22350004)
2012
10
Giant epithelial malignancies (Basal cell carcinoma, squamous cell carcinoma): a series of 20 tumors from a single center. (22557850)
2012
11
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
12
Secondary malignant giant cell tumor of the clivus: case report. (22277296)
2012
13
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. (21924561)
2011
14
Primary malignant giant-cell tumor of bone has high survival rate. (19902306)
2010
15
A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases. (20860830)
2010
16
Primary malignancy in giant cell tumor: a case report. (20169281)
2009
17
Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur. (18440162)
2008
18
Fungating primary locally malignant giant cell tumor of ulna: a case report. (18552892)
2008
19
Diffuse-type giant cell tumor/pigmented villonodular synovitis arising in the sacrum: malignant form. (17685937)
2007
20
Primary malignant giant cell tumor of bone: a series of three rare cases. (17592717)
2007
21
Primary de novo malignant giant cell tumor of kidney: a case report. (15207006)
2004
22
Malignant giant cell tumor of the tendon sheath. (14693023)
2004
23
Malignant giant cell tumor of soft parts. (14997349)
2004
24
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
25
A malignant ovarian tumor with osteoclast-like giant cells. (12766594)
2003
26
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). (9042281)
1997
27
Tumor progression in a giant cell type malignant fibrous histiocytoma of bone: clinical, radiologic, histologic, and cytogenetic evidence. (7519876)
1994
28
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. (8230758)
1993
29
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. (8319177)
1993
30
Significance of chromosomal abnormalities in a malignant giant cell tumor of bone. (1756489)
1991
31
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. (2175663)
1990
32
Malignant giant cell tumor of soft parts presenting as a skin tumor. (2658646)
1989
33
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. (2545593)
1989
34
Malignant giant cell tumor of tendon sheath. Report of a case. (2994359)
1985
35
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. (6490003)
1984
36
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
37
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. (6937839)
1981
38
Malignant giant-cell tumor of the distal end of the radius treated by a free vascularized fibular transplant. (7240328)
1981
39
Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study. (7226022)
1981
40
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
41
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
42
Malignant giant cell tumor in a dog. (914686)
1977
43
Primary prostatic malignant giant cell tumor of soft parts. (1067447)
1976
44
Malignant giant cell tumor of the soft tissue: angiographic manifestations. (935483)
1976
45
Malignant giant cell tumor of the mandible: report of case. (13665456)
1959
46
Case report; malignant giant cell tumor. (13620562)
1959
47
Malignant giant-cell tumor of the ulna; report of a case of eighteen years' duration. (13587583)
1958
48
Malignant giant cell tumor of bone. (13272874)
1955
49
TUMOR clinic conference: giant cell epulis of the gum, with questionable malignant change. (14821950)
1951
50
Malignant giant cell tumor of bone. (19970407)
1938

Genetic Variations for Malignant Giant Cell Tumor

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Expression for genes affiliated with Malignant Giant Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor

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Pathways for genes affiliated with Malignant Giant Cell Tumor

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4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ACTC1, DES
2
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9.3ACTC1, DES
3
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9.3ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1procollagen449.5ACTC1, DES
23-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4S100B, DES
3ccl444 2810.4DES, S100B
4biotin44 11 2411.2ACTC1, DES
5orcein448.9ACTC1, DES, S100B
6s 100448.9S100B, DES, ACTC1
7reticulin448.9ACTC1, DES, S100B
8mucicarmine448.9S100B, DES, ACTC1
9b 723448.9ACTC1, DES, S100B
10hematoxylin448.9ACTC1, DES, S100B
11formaldehyde44 249.8S100B, DES, ACTC1
12imatinib44 49 1110.8ACTC1, DES, S100B
13bromodeoxyuridine448.8DES, S100B
14glycogen44 249.8ACTC1, DES, S100B
15paraffin448.8S100B, DES, ACTC1
16iron44 249.8ACTC1, DES, S100B
17creatinine448.8ACTC1, DES, S100B
18progesterone44 59 28 11 2412.8ACTC1, DES, S100B
19testosterone44 59 11 2411.8ACTC1, DES, S100B
20steroid448.7S100B, DES, ACTC1
21vegf448.7ACTC1, DES, S100B
22oxygen44 249.7S100B, DES, ACTC1
23estrogen448.6ACTC1, DES, S100B
24retinoic acid44 249.6ACTC1, DES, S100B
25glucose448.5S100B, DES, ACTC1
26tyrosine448.5ACTC1, DES, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor

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16Gene Ontology
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Biological processes related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.3ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor

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Sources for Malignant Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet