MCID: MLG067
MIFTS: 27

Malignant Giant Cell Tumor malady

Summaries for Malignant Giant Cell Tumor

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33MalaCards
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MalaCards: Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to dermatofibrosarcoma protuberans and bone giant cell tumor. An important gene associated with Malignant Giant Cell Tumor is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds procollagen and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide have been mentioned in the context of this disorder.

Aliases & Classifications for Malignant Giant Cell Tumor

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT
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Aliases & Descriptions:

malignant giant cell tumor 8
malignant tumor, giant cell type 8 61
malignant giant cell neoplasm 8


External Ids:

Disease Ontology8 DOID:2705
SNOMED-CT57 83950009
NCIt40 C4090

Related Diseases for Malignant Giant Cell Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases in the giant cell tumor family:

malignant giant cell tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1dermatofibrosarcoma protuberans30.2S100B, DES, ACTC1
2bone giant cell tumor10.8
3pigmented villonodular synovitis10.4
4villonodular synovitis10.4
5synovitis10.4
6malignant giant cell tumor of the tendon sheath10.3
7bone giant cell sarcoma10.3
8malignant giant cell tumor of soft parts10.3
9dermatofibrosarcoma10.2
10bone osteosarcoma10.2
11uterus leiomyosarcoma10.2
12lymphangioleiomyomatosis10.0DES
13infantile myofibromatosis10.0DES
14fasciitis10.0ACTC1
15angiosarcoma10.0ACTC1
16lipoma10.0DES
17liposarcoma10.0DES
18fibrous meningioma10.0S100B
19teratoma10.0ACTC1
20adenoma10.0ACTC1
21perineurioma10.0S100B
22syringoma10.0S100B
23ganglioglioma10.0S100B
24hemangioblastoma10.0S100B
25meningioma10.0S100B
26paraganglioma10.0S100B
27histiocytosis10.0S100B
28hemangioma10.0ACTC1
29hypertrophic cardiomyopathy10.0ACTC1
30glomus tumor10.0ACTC1, DES
31angiomyolipoma10.0ACTC1, DES
32rhabdoid tumor10.0ACTC1, DES
33epithelioid leiomyosarcoma10.0ACTC1, DES
34pseudosarcomatous fibromatosis10.0DES, ACTC1
35spindle cell carcinoma10.0ACTC1, DES
36adenosarcoma10.0DES, ACTC1
37endometrial stromal sarcoma10.0DES, ACTC1
38embryonal rhabdomyosarcoma10.0DES, ACTC1
39abrikosov's tumor10.0ACTC1, DES
40desmoid tumor10.0ACTC1, DES
41benign mesothelioma10.0ACTC1, DES
42fibromatosis10.0ACTC1, DES
43tuberous sclerosis10.0S100B
44papilloma10.0ACTC1
45chondrosarcoma10.0DES, S100B
46sex cord-gonadal stromal tumor10.0DES, S100B
47noonan syndrome10.0ACTC1, DES
48myoepithelioma10.0ACTC1, S100B
49synovial sarcoma10.0S100B, DES
50granular cell tumor10.0S100B, DES

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to malignant giant cell tumor

Clinical Features for Malignant Giant Cell Tumor

Drugs & Therapeutics for Malignant Giant Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Giant Cell Tumor

Anatomical Context for Malignant Giant Cell Tumor

Animal Models for Malignant Giant Cell Tumor or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Malignant Giant Cell Tumor

Sources:
51PubMed
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Articles related to Malignant Giant Cell Tumor:

(show top 50)    (show all 77)
idTitleAuthorsYear
1
Soft Tissue Giant Cell Tumor of Low Malignant Potential of the Neck: A Case Report and Review of the Literature. (24101352)
2014
2
Giant cell tumor of the larynx: a case of malignant sarcomatous transformation. (23780608)
2013
3
Giant malignant granular cell tumor (GCT) of the posterior mediastinum. (23857402)
2013
4
Malignant giant cell tumor of the tendon sheath. (23981429)
2013
5
Late malignant transformation of giant cell tumor of bone 41 years after primary surgery. (23027500)
2012
6
Histological and clinical characteristics of malignant giant cell tumor of bone. (22350004)
2012
7
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
8
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. (21924561)
2011
9
CCND1 and MET genomic amplification during malignant transformation of a giant cell tumor of bone. (21098327)
2011
10
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. (21237496)
2011
11
Intramedullary spinal cord metastasis following spontaneous malignant transformation from giant cell tumor of bone 16 years after pulmonary metastasis. (21249405)
2011
12
Malignant giant cell tumor of the vulva. (19952930)
2010
13
Primary malignant giant-cell tumor of bone has high survival rate. (19902306)
2010
14
Malignant giant cell tumor in the posterior fossa of a neonate. (20192645)
2010
15
Malignant hypercalcemia associated with a parathyroid macrocyst and the early genesis of a giant cell tumor. (16360825)
2006
16
Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. (16205965)
2006
17
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells. (15043462)
2004
18
Malignant giant cell tumor of the tendon sheath. (14693023)
2004
19
Malignant giant cell tumor of soft parts. (14997349)
2004
20
Malignant giant cell tumor of the sphenoid. (12715335)
2003
21
A malignant ovarian tumor with osteoclast-like giant cells. (12766594)
2003
22
A successfully resected case of giant malignant mediastinal germ cell tumor]. (12174631)
2002
23
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. (11220389)
2001
24
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). (11079016)
2000
25
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. (10496598)
1999
26
Tumor progression in a giant cell type malignant fibrous histiocytoma of bone: clinical, radiologic, histologic, and cytogenetic evidence. (7519876)
1994
27
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. (8230758)
1993
28
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. (2317762)
1990
29
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. (2554283)
1989
30
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. (3115731)
1987
31
Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients. (3745247)
1986
32
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. (6490003)
1984
33
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
34
Malignant giant cell tumor of the frontal bone. (6585707)
1984
35
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. (6937839)
1981
36
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. (7270164)
1981
37
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. (227563)
1979
38
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. (314048)
1979
39
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. (379085)
1979
40
Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. (212864)
1978
41
Malignant giant cell tumor in a dog. (914686)
1977
42
Feline malignant giant cell tumor of bone associated with C-type virus particles. (185002)
1976
43
Primary prostatic malignant giant cell tumor of soft parts. (1067447)
1976
44
Malignant giant cell tumor of the soft tissue: angiographic manifestations. (935483)
1976
45
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972
46
Malignant giant cell tumor of the sphenoid bone and its differential diagnosis. (5410307)
1970
47
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). (5272232)
1970
48
Case report; malignant giant cell tumor. (13620562)
1959
49
Malignant giant cell tumor of bone. (13272874)
1955
50
TUMOR clinic conference: giant cell epulis of the gum, with questionable malignant change. (14821950)
1951

Genetic Variations for Malignant Giant Cell Tumor

Expression for genes affiliated with Malignant Giant Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for genes affiliated with Malignant Giant Cell Tumor

Sources:
4Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 54Reactome
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Pathways related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ACTC1, DES
2
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9.3ACTC1, DES
3
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9.3ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1procollagen459.5ACTC1, DES
23-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.4S100B, DES
3ccl445 2910.4DES, S100B
4biotin45 11 2411.2ACTC1, DES
5orcein458.9ACTC1, DES, S100B
6s 100458.9S100B, DES, ACTC1
7reticulin458.9ACTC1, DES, S100B
8mucicarmine458.9S100B, DES, ACTC1
9b 723458.9ACTC1, DES, S100B
10hematoxylin458.9ACTC1, DES, S100B
11formaldehyde45 249.8S100B, DES, ACTC1
12imatinib45 50 1110.8ACTC1, DES, S100B
13bromodeoxyuridine458.8DES, S100B
14glycogen45 249.8ACTC1, DES, S100B
15paraffin458.8S100B, DES, ACTC1
16iron45 249.8ACTC1, DES, S100B
17creatinine458.8ACTC1, DES, S100B
18progesterone45 60 29 11 2412.8ACTC1, DES, S100B
19testosterone45 60 11 2411.8ACTC1, DES, S100B
20steroid458.7S100B, DES, ACTC1
21vegf458.7ACTC1, DES, S100B
22oxygen45 249.7S100B, DES, ACTC1
23estrogen458.6ACTC1, DES, S100B
24retinoic acid45 249.6ACTC1, DES, S100B
25glucose458.5S100B, DES, ACTC1
26tyrosine458.5ACTC1, DES, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor

Sources:
16Gene Ontology
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Biological processes related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.3ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor

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Sources for Malignant Giant Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet