MCID: MLG067
MIFTS: 34

Malignant Giant Cell Tumor malady

Cancer diseases category

Summaries for Malignant Giant Cell Tumor

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32MalaCards
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MalaCards: Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to giant cell tumor and chondrosarcoma. An important gene associated with Malignant Giant Cell Tumor is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds procollagen and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide have been mentioned in the context of this disorder. Affiliated tissues include bone, uterus and skin.

Aliases & Classifications for Malignant Giant Cell Tumor

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant giant cell tumor 8
malignant tumor, giant cell type 8 60
malignant giant cell neoplasm 8


External Ids:

Disease Ontology8 DOID:2705
SNOMED-CT56 83950009
NCIt39 C4090

Related Diseases for Malignant Giant Cell Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Giant Cell Tumor family:

malignant giant cell tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.5S100B, DES, ACTC1
2chondrosarcoma30.2S100B, DES
3leiomyosarcoma30.1ACTC1, DES, S100B
4sarcoma30.1ACTC1, DES, S100B
5bone giant cell tumor10.8
6malignant giant cell tumor of soft parts10.7
7malignant giant cell tumor of the tendon sheath10.6
8pigmented villonodular synovitis10.4
9villonodular synovitis10.4
10synovitis10.4
11bone giant cell sarcoma10.3
12dermatofibrosarcoma10.1
13bone osteosarcoma10.1
14fibrosarcoma10.1
15osteosarcoma10.1
16prostatitis10.1
17uterus leiomyosarcoma10.1
18lymphangioleiomyomatosis10.0DES
19infantile myofibromatosis10.0DES
20fasciitis10.0ACTC1
21angiosarcoma10.0ACTC1
22lipoma10.0DES
23liposarcoma10.0DES
24fibrous meningioma10.0S100B
25teratoma10.0ACTC1
26adenoma10.0ACTC1
27syringoma10.0S100B
28perineurioma10.0S100B
29ganglioglioma10.0S100B
30hemangioblastoma10.0S100B
31meningioma10.0S100B
32paraganglioma10.0S100B
33histiocytosis10.0S100B
34hemangioma10.0ACTC1
35hypertrophic cardiomyopathy10.0ACTC1
36glomus tumor10.0ACTC1, DES
37angiomyolipoma10.0DES, ACTC1
38rhabdoid tumor10.0DES, ACTC1
39epithelioid leiomyosarcoma10.0DES, ACTC1
40pseudosarcomatous fibromatosis10.0DES, ACTC1
41spindle cell carcinoma10.0DES, ACTC1
42adenosarcoma10.0DES, ACTC1
43endometrial stromal sarcoma10.0DES, ACTC1
44embryonal rhabdomyosarcoma10.0ACTC1, DES
45abrikosov's tumor10.0DES, ACTC1
46desmoid tumor10.0ACTC1, DES
47benign mesothelioma10.0DES, ACTC1
48fibromatosis10.0DES, ACTC1
49tuberous sclerosis10.0S100B
50papilloma10.0ACTC1

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to malignant giant cell tumor

Clinical Features for Malignant Giant Cell Tumor

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Drugs & Therapeutics for Malignant Giant Cell Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Giant Cell Tumor

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Anatomical Context for Malignant Giant Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Malignant Giant Cell Tumor:

32
Bone, Uterus, Skin, Spinal cord, Kidney, Prostate

Animal Models for Malignant Giant Cell Tumor or affiliated genes

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Publications for Malignant Giant Cell Tumor

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50PubMed
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Articles related to Malignant Giant Cell Tumor:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Soft Tissue Giant Cell Tumor of Low Malignant Potential of the Neck: A Case Report and Review of the Literature. (24101352)
2014
2
Giant malignant granular cell tumor (GCT) of the posterior mediastinum. (23857402)
2013
3
Malignant giant cell tumor of the tendon sheath. (23981429)
2013
4
Cytogenetic study of secondary malignancy in giant cell tumor. (23929353)
2013
5
Late malignant transformation of giant cell tumor of bone 41 years after primary surgery. (23027500)
2012
6
Malignant diffuse-type tenosynovial giant cell tumor of the buttock. (22827766)
2012
7
CCND1 and MET genomic amplification during malignant transformation of a giant cell tumor of bone. (21098327)
2011
8
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. (21237496)
2011
9
Intramedullary spinal cord metastasis following spontaneous malignant transformation from giant cell tumor of bone 16 years after pulmonary metastasis. (21249405)
2011
10
Malignant giant cell tumor of the vulva. (19952930)
2010
11
Primary malignant giant-cell tumor of bone has high survival rate. (19902306)
2010
12
Malignant giant cell tumor in the posterior fossa of a neonate. (20192645)
2010
13
Primary malignancy in giant cell tumor: a case report. (20169281)
2009
14
Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur. (18440162)
2008
15
Malignant hypercalcemia associated with a parathyroid macrocyst and the early genesis of a giant cell tumor. (16360825)
2006
16
Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. (16205965)
2006
17
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells. (15043462)
2004
18
Malignant giant cell tumor of the tendon sheath. (14693023)
2004
19
Malignant giant cell tumor of soft parts. (14997349)
2004
20
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
21
Malignant giant cell tumor of the sphenoid. (12715335)
2003
22
A malignant ovarian tumor with osteoclast-like giant cells. (12766594)
2003
23
A successfully resected case of giant malignant mediastinal germ cell tumor]. (12174631)
2002
24
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. (11220389)
2001
25
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). (11079016)
2000
26
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. (10496598)
1999
27
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. (2317762)
1990
28
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. (2554283)
1989
29
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. (3115731)
1987
30
Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients. (3745247)
1986
31
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. (6490003)
1984
32
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
33
Malignant giant cell tumor of the frontal bone. (6585707)
1984
34
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. (6937839)
1981
35
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. (7270164)
1981
36
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. (227563)
1979
37
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. (314048)
1979
38
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. (379085)
1979
39
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
40
Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. (212864)
1978
41
Malignant giant cell tumor in a dog. (914686)
1977
42
Feline malignant giant cell tumor of bone associated with C-type virus particles. (185002)
1976
43
Primary prostatic malignant giant cell tumor of soft parts. (1067447)
1976
44
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972
45
Malignant giant cell tumor of the sphenoid bone and its differential diagnosis. (5410307)
1970
46
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). (5272232)
1970
47
Malignant giant cell tumor of the mandible: report of case. (13665456)
1959
48
Case report; malignant giant cell tumor. (13620562)
1959
49
Malignant giant cell tumor of bone. (13272874)
1955
50
Malignant giant cell tumor of bone. (19970407)
1938

Genetic Variations for Malignant Giant Cell Tumor

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Expression for genes affiliated with Malignant Giant Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for genes affiliated with Malignant Giant Cell Tumor

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Sources:
4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ACTC1, DES
2
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9.3ACTC1, DES
3
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9.3ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1procollagen449.5ACTC1, DES
23-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4S100B, DES
3ccl444 2810.4DES, S100B
4biotin44 11 2411.2ACTC1, DES
5orcein448.9ACTC1, DES, S100B
6s 100448.9S100B, DES, ACTC1
7reticulin448.9ACTC1, DES, S100B
8mucicarmine448.9S100B, DES, ACTC1
9b 723448.9ACTC1, DES, S100B
10hematoxylin448.9ACTC1, DES, S100B
11formaldehyde44 249.8S100B, DES, ACTC1
12imatinib44 49 1110.8ACTC1, DES, S100B
13bromodeoxyuridine448.8DES, S100B
14glycogen44 249.8ACTC1, DES, S100B
15paraffin448.8S100B, DES, ACTC1
16iron44 249.8ACTC1, DES, S100B
17creatinine448.8ACTC1, DES, S100B
18progesterone44 59 28 11 2412.8ACTC1, DES, S100B
19testosterone44 59 11 2411.8ACTC1, DES, S100B
20steroid448.7S100B, DES, ACTC1
21vegf448.7ACTC1, DES, S100B
22oxygen44 249.7S100B, DES, ACTC1
23estrogen448.6ACTC1, DES, S100B
24retinoic acid44 249.6ACTC1, DES, S100B
25glucose448.5S100B, DES, ACTC1
26tyrosine448.5ACTC1, DES, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor

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16Gene Ontology
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Biological processes related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.3ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor

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Sources for Malignant Giant Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet