MCID: MLG067
MIFTS: 34

Malignant Giant Cell Tumor malady

Cancer diseases category

Summaries for Malignant Giant Cell Tumor

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MalaCards based summary: Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to giant cell tumor and chondrosarcoma. An important gene associated with Malignant Giant Cell Tumor is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include bone, uterus and kidney.

Aliases & Classifications for Malignant Giant Cell Tumor

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Malignant Giant Cell Tumor, Aliases & Descriptions:

Name: Malignant Giant Cell Tumor 10
Malignant Tumor, Giant Cell Type 10 62
 
Malignant Giant Cell Neoplasm 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology10 DOID:2705
SNOMED-CT57 83950009
NCIt40 C4090

Related Diseases for Malignant Giant Cell Tumor

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Diseases in the Giant Cell Tumor family:

malignant giant cell tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 62)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.6DES, ACTC1, S100B
2chondrosarcoma30.3DES, S100B
3fibrosarcoma30.2ACTC1, DES
4dermatofibrosarcoma protuberans30.2DES, ACTC1, S100B
5leiomyosarcoma30.2S100B, ACTC1, DES
6sarcoma30.2S100B, ACTC1, DES
7malignant giant cell tumor of soft parts10.7
8malignant giant cell tumor of the tendon sheath10.6
9pigmented villonodular synovitis10.4
10villonodular synovitis10.4
11synovitis10.4
12bone giant cell sarcoma10.2
13bone osteosarcoma10.2
14prostatitis10.2
15fibrous meningioma10.0S100B
16syringoma10.0S100B
17histiocytosis10.0S100B
18ganglioglioma10.0S100B
19fasciitis10.0ACTC1
20infantile myofibromatosis10.0DES
21papilloma10.0ACTC1
22myoepithelioma10.0ACTC1, S100B
23malignant peripheral nerve sheath tumor10.0ACTC1, S100B
24neurofibroma10.0S100B, ACTC1
25salivary gland adenoid cystic carcinoma10.0ACTC1, S100B
26microphthalmia10.0S100B, ACTC1
27granular cell tumor10.0DES, S100B
28sex cord-gonadal stromal tumor10.0DES, S100B
29glomus tumor10.0DES, ACTC1
30epithelioid leiomyosarcoma10.0DES, ACTC1
31pseudosarcomatous fibromatosis10.0ACTC1, DES
32spindle cell carcinoma10.0ACTC1, DES
33chordoma10.0DES, S100B
34desmoid disease, hereditary10.0ACTC1, DES
35adenosarcoma10.0ACTC1, DES
36endometrial stromal sarcoma10.0ACTC1, DES
37rhabdoid tumor10.0ACTC1, DES
38angiomyolipoma10.0ACTC1, DES
39fibroma10.0DES, ACTC1
40sarcoma, synovial10.0S100B, DES
41embryonal rhabdomyosarcoma10.0DES, ACTC1
42fibromatosis10.0ACTC1, DES
43abrikosov's tumor10.0DES, ACTC1
44peripheral primitive neuroectodermal tumor10.0S100B, DES
45mesothelioma10.0ACTC1, DES
46dilated cardiomyopathy10.0ACTC1, DES
47spindle cell sarcoma10.0S100B, ACTC1, DES
48cutaneous fibrous histiocytoma10.0S100B, ACTC1, DES
49fibrous histiocytoma10.0DES, ACTC1, S100B
50hemangiopericytoma10.0DES, ACTC1, S100B

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to malignant giant cell tumor

Symptoms for Malignant Giant Cell Tumor

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Drugs & Therapeutics for Malignant Giant Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Malignant Giant Cell Tumor

Search NIH Clinical Center for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

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Anatomical Context for Malignant Giant Cell Tumor

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MalaCards organs/tissues related to Malignant Giant Cell Tumor:

33
Bone, Uterus, Kidney, Lung, Skin, Prostate

Animal Models for Malignant Giant Cell Tumor or affiliated genes

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Publications for Malignant Giant Cell Tumor

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Articles related to Malignant Giant Cell Tumor:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Malignant giant cell tumor of the rib with lung metastasis in a man. (25276374)
2014
2
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. (24436827)
2013
3
Malignant giant cell tumor of the tendon sheath. (23981429)
2013
4
Histological and clinical characteristics of malignant giant cell tumor of bone. (22350004)
2012
5
Secondary malignant giant cell tumor of the clivus: case report. (22277296)
2012
6
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. (21924561)
2011
7
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. (21237496)
2011
8
Malignant giant cell tumor of the vulva. (19952930)
2010
9
Primary malignant giant-cell tumor of bone has high survival rate. (19902306)
2010
10
Fungating primary locally malignant giant cell tumor of ulna: a case report. (18552892)
2008
11
Primary de novo malignant giant cell tumor of kidney: a case report. (15207006)
2004
12
Malignant giant cell tumor of the tendon sheath. (14693023)
2004
13
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
14
Malignant giant cell tumor of the sphenoid. (12715335)
2003
15
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. (11220389)
2001
16
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). (11079016)
2000
17
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). (9042281)
1997
18
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. (8230758)
1993
19
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. (8319177)
1993
20
Significance of chromosomal abnormalities in a malignant giant cell tumor of bone. (1756489)
1991
21
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. (2317762)
1990
22
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. (2175663)
1990
23
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. (2554283)
1989
24
Malignant giant cell tumor of soft parts presenting as a skin tumor. (2658646)
1989
25
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. (2545593)
1989
26
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. (3115731)
1987
27
Malignant giant cell tumor of tendon sheath. Report of a case. (2994359)
1985
28
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. (6490003)
1984
29
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
30
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. (6937839)
1981
31
Malignant giant-cell tumor of the distal end of the radius treated by a free vascularized fibular transplant. (7240328)
1981
32
Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study. (7226022)
1981
33
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. (7270164)
1981
34
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. (227563)
1979
35
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. (314048)
1979
36
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. (379085)
1979
37
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
38
Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. (212864)
1978
39
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
40
Malignant giant cell tumor in a dog. (914686)
1977
41
Feline malignant giant cell tumor of bone associated with C-type virus particles. (185002)
1976
42
Malignant giant cell tumor of the tendon sheath. Ultrastructural study and review of the literature. (4346849)
1973
43
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972
44
Malignant giant cell tumor of the sphenoid bone and its differential diagnosis. (5410307)
1970
45
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). (5272232)
1970
46
Malignant giant cell tumor of the mandible: report of case. (13665456)
1959
47
Case report; malignant giant cell tumor. (13620562)
1959
48
Malignant giant-cell tumor of the ulna; report of a case of eighteen years' duration. (13587583)
1958
49
Malignant giant cell tumor of bone. (13272874)
1955
50
Malignant giant cell tumor of bone. (19970407)
1938

Variations for Malignant Giant Cell Tumor

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Expression for genes affiliated with Malignant Giant Cell Tumor

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Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for genes affiliated with Malignant Giant Cell Tumor

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Pathways related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ACTC1, DES
2
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.0ACTC1, DES
3
Show member pathways
9.0ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor

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Compounds related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.5DES, S100B
2ccl445 3010.4S100B, DES
3bromodeoxyuridine459.3S100B, DES
4procollagen459.3ACTC1, DES
5methionine459.2S100B, DES
6biotin45 26 1311.2ACTC1, DES
7ethanol45 51 26 1312.2DES, S100B
8norepinephrine45 26 1311.1S100B, DES
9proline459.1S100B, DES
10acetylcholine45 51 30 26 1313.0S100B, DES
11orcein458.9S100B, ACTC1, DES
12s 100458.9DES, ACTC1, S100B
13reticulin458.9S100B, ACTC1, DES
14mucicarmine458.9DES, ACTC1, S100B
15b 723458.9S100B, ACTC1, DES
16hematoxylin458.9DES, ACTC1, S100B
17formaldehyde45 269.9S100B, ACTC1, DES
18imatinib45 51 1310.9DES, ACTC1, S100B
19glycogen45 269.9S100B, ACTC1, DES
20paraffin458.9DES, ACTC1, S100B
21iron45 269.9S100B, ACTC1, DES
22creatinine458.9DES, ACTC1, S100B
23progesterone45 30 61 26 1312.8S100B, ACTC1, DES
24testosterone45 61 26 1311.8S100B, ACTC1, DES
25steroid458.8S100B, ACTC1, DES
26vegf458.8DES, ACTC1, S100B
27oxygen45 269.8DES, ACTC1, S100B
28estrogen458.8DES, ACTC1, S100B
29retinoic acid45 269.7S100B, ACTC1, DES
30glucose458.7DES, ACTC1, S100B
31tyrosine458.7DES, ACTC1, S100B
32calcium45 51 26 1311.2DES, ACTC1, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor

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Biological processes related to Malignant Giant Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.0ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor

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Sources for Malignant Giant Cell Tumor

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet