MCID: MLG018
MIFTS: 30

Malignant Giant Cell Tumor of Soft Parts malady

Cancer diseases category

Summaries for Malignant Giant Cell Tumor of Soft Parts

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MalaCards: Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to giant cell tumor and dermatofibrosarcoma protuberans. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include skin and prostate.

Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

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9Disease Ontology, 63UMLS, 41NCIt, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant giant cell tumor of soft parts 9
malignant giant cell neoplasm of soft parts 9


External Ids:

Disease Ontology9 DOID:5638
SNOMED-CT59 48460009
NCIt41 C8380

Related Diseases for Malignant Giant Cell Tumor of Soft Parts

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18GeneCards, 19GeneDecks
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Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.3ACTC1, DES, S100B
2dermatofibrosarcoma protuberans30.5S100B, ACTC1, DES
3malignant giant cell tumor10.9
4dermatofibrosarcoma10.4
5prostatitis10.4
6fibrous meningioma10.1S100B
7syringoma10.1S100B
8histiocytosis10.1S100B
9ganglioglioma10.1S100B
10fasciitis10.1ACTC1
11infantile myofibromatosis10.1DES
12papilloma10.1ACTC1
13myoepithelioma10.0S100B, ACTC1
14malignant peripheral nerve sheath tumor10.0ACTC1, S100B
15neurofibroma10.0ACTC1, S100B
16adenoid cystic carcinoma10.0ACTC1, S100B
17microphthalmia10.0S100B, ACTC1
18granular cell tumor10.0S100B, DES
19sex cord-gonadal stromal tumor10.0DES, S100B
20glomus tumor10.0ACTC1, DES
21epithelioid leiomyosarcoma10.0DES, ACTC1
22pseudosarcomatous fibromatosis10.0ACTC1, DES
23spindle cell carcinoma10.0DES, ACTC1
24chordoma10.0DES, S100B
25desmoid tumor10.0DES, ACTC1
26adenosarcoma10.0ACTC1, DES
27endometrial stromal sarcoma10.0ACTC1, DES
28rhabdoid tumor10.0DES, ACTC1
29angiomyolipoma10.0ACTC1, DES
30embryonal rhabdomyosarcoma10.0DES, ACTC1
31synovial sarcoma10.0S100B, DES
32fibroma10.0DES, ACTC1
33fibromatosis10.0ACTC1, DES
34abrikosov's tumor10.0DES, ACTC1
35peripheral primitive neuroectodermal tumor10.0S100B, DES
36benign mesothelioma10.0ACTC1, DES
37chondrosarcoma10.0S100B, DES
38dilated cardiomyopathy10.0DES, ACTC1
39fibrosarcoma10.0ACTC1, DES
40spindle cell sarcoma10.0DES, ACTC1, S100B
41cutaneous fibrous histiocytoma10.0S100B, ACTC1, DES
42fibrous histiocytoma10.0ACTC1, DES, S100B
43hemangiopericytoma10.0DES, S100B, ACTC1
44malignant mixed mullerian tumor10.0DES, S100B, ACTC1
45smooth muscle tumor10.0DES, ACTC1, S100B
46malignant fibroxanthoma10.0S100B, DES, ACTC1
47pleomorphic adenoma10.0DES, S100B, ACTC1
48gastrointestinal stromal tumor9.9S100B, ACTC1, DES
49leiomyosarcoma9.9S100B, ACTC1, DES
50neurilemmoma9.9DES, ACTC1, S100B

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:



Diseases related to malignant giant cell tumor of soft parts

Symptoms for Malignant Giant Cell Tumor of Soft Parts

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Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

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Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

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34MalaCards
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MalaCards organs/tissues related to Malignant Giant Cell Tumor of Soft Parts:

34
Skin, Prostate

Animal Models for Malignant Giant Cell Tumor of Soft Parts or affiliated genes

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Publications for Malignant Giant Cell Tumor of Soft Parts

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53PubMed
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Articles related to Malignant Giant Cell Tumor of Soft Parts:

idTitleAuthorsYear
1
Malignant giant cell tumor of soft parts. (14997349)
2004
2
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
3
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. (10496598)
1999
4
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. (8319177)
1993
5
Malignant giant cell tumor of soft parts presenting as a skin tumor. (2658646)
1989
6
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
7
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
8
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
9
Primary prostatic malignant giant cell tumor of soft parts. (1067447)
1976
10
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972

Variations for Malignant Giant Cell Tumor of Soft Parts

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Expression for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

Pathways for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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51PathCards, 5Cell Signaling Technology, 31KEGG, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ACTC1, DES
2
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy39
9.0ACTC1, DES
3
Show member pathways
9.0ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience
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Compounds related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.5DES, S100B
2ccl446 3010.4S100B, DES
3bromodeoxyuridine469.3DES, S100B
4procollagen469.3ACTC1, DES
5methionine469.2S100B, DES
6biotin46 25 1211.2ACTC1, DES
7ethanol46 52 25 1212.2S100B, DES
8norepinephrine46 25 1211.1DES, S100B
9proline469.1DES, S100B
10acetylcholine46 52 30 25 1213.0S100B, DES
11orcein468.9ACTC1, S100B, DES
12s 100468.9S100B, ACTC1, DES
13reticulin468.9DES, ACTC1, S100B
14mucicarmine468.9S100B, ACTC1, DES
15b 723468.9S100B, ACTC1, DES
16hematoxylin468.9DES, ACTC1, S100B
17formaldehyde46 259.9DES, ACTC1, S100B
18imatinib46 52 1210.9DES, S100B, ACTC1
19glycogen46 259.9S100B, DES, ACTC1
20paraffin468.9S100B, ACTC1, DES
21iron46 259.9DES, S100B, ACTC1
22creatinine468.9ACTC1, DES, S100B
23progesterone46 30 62 25 1212.8DES, ACTC1, S100B
24testosterone46 62 25 1211.8S100B, DES, ACTC1
25steroid468.8S100B, ACTC1, DES
26vegf468.8ACTC1, DES, S100B
27oxygen46 259.8DES, ACTC1, S100B
28estrogen468.8ACTC1, S100B, DES
29retinoic acid46 259.7S100B, ACTC1, DES
30glucose468.7ACTC1, DES, S100B
31tyrosine468.7ACTC1, S100B, DES
32calcium46 52 25 1211.2S100B, ACTC1, DES

GO Terms for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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17Gene Ontology
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Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.0ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Sources for Malignant Giant Cell Tumor of Soft Parts

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet