MCID: MLG018
MIFTS: 31

Malignant Giant Cell Tumor of Soft Parts malady

Cancer diseases category
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Summaries for Malignant Giant Cell Tumor of Soft Parts

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MalaCards based summary: Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to giant cell tumor and dermatofibrosarcoma protuberans. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include skin and prostate.

Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

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Malignant Giant Cell Tumor of Soft Parts, Aliases & Descriptions:

Name: Malignant Giant Cell Tumor of Soft Parts 8 62
 
Malignant Giant Cell Neoplasm of Soft Parts 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:5638
SNOMED-CT57 48460009
NCIt39 C8380

Related Diseases for Malignant Giant Cell Tumor of Soft Parts

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Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.1DES, ACTC1, S100B
2dermatofibrosarcoma protuberans30.3DES, ACTC1, S100B
3malignant giant cell tumor10.9
4prostatitis10.4
5fibrous meningioma10.4S100B
6syringoma10.4S100B
7histiocytosis10.4S100B
8ganglioglioma10.4S100B
9fasciitis10.4ACTC1
10infantile myofibromatosis10.3DES
11papilloma10.3ACTC1
12myoepithelioma10.1ACTC1, S100B
13malignant peripheral nerve sheath tumor10.1ACTC1, S100B
14neurofibroma10.1S100B, ACTC1
15salivary gland adenoid cystic carcinoma10.1ACTC1, S100B
16microphthalmia10.1S100B, ACTC1
17granular cell tumor10.0DES, S100B
18sex cord-gonadal stromal tumor10.0DES, S100B
19paraganglioma10.0DES, ACTC1
20epithelioid leiomyosarcoma10.0DES, ACTC1
21pseudosarcomatous fibromatosis10.0ACTC1, DES
22spindle cell carcinoma10.0ACTC1, DES
23chordoma10.0DES, S100B
24desmoid tumor10.0ACTC1, DES
25adenosarcoma10.0ACTC1, DES
26endometrial stromal sarcoma10.0ACTC1, DES
27rhabdoid tumor10.0ACTC1, DES
28angiomyolipoma10.0ACTC1, DES
29fibroma10.0DES, ACTC1
30synovial sarcoma10.0S100B, DES
31embryonal rhabdomyosarcoma10.0DES, ACTC1
32fibromatosis10.0ACTC1, DES
33abrikosov's tumor10.0DES, ACTC1
34peripheral primitive neuroectodermal tumor9.9S100B, DES
35malignant mesothelioma9.9ACTC1, DES
36chondrosarcoma9.9DES, S100B
37dilated cardiomyopathy9.8ACTC1, DES
38fibrosarcoma9.8ACTC1, DES
39spindle cell sarcoma9.8S100B, ACTC1, DES
40cutaneous fibrous histiocytoma9.8S100B, ACTC1, DES
41fibrous histiocytoma9.8DES, ACTC1, S100B
42hemangiopericytoma9.8DES, ACTC1, S100B
43malignant mixed mullerian tumor9.8DES, ACTC1, S100B
44smooth muscle tumor9.8S100B, ACTC1, DES
45malignant fibroxanthoma9.8DES, ACTC1, S100B
46pleomorphic adenoma9.8DES, ACTC1, S100B
47gastrointestinal stromal tumor9.8DES, ACTC1, S100B
48leiomyosarcoma9.8S100B, ACTC1, DES
49neurilemmoma9.8S100B, ACTC1, DES
50leiomyoma9.8DES, ACTC1, S100B

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:



Diseases related to malignant giant cell tumor of soft parts

Symptoms for Malignant Giant Cell Tumor of Soft Parts

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Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

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Drug clinical trials:

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Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

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Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

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MalaCards organs/tissues related to Malignant Giant Cell Tumor of Soft Parts:

32
Skin, Prostate

Animal Models for Malignant Giant Cell Tumor of Soft Parts or affiliated genes

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Publications for Malignant Giant Cell Tumor of Soft Parts

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Articles related to Malignant Giant Cell Tumor of Soft Parts:

idTitleAuthorsYear
1
Malignant giant cell tumor of soft parts. (14997349)
2004
2
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
3
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. (10496598)
1999
4
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. (8319177)
1993
5
Malignant giant cell tumor of soft parts presenting as a skin tumor. (2658646)
1989
6
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
7
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
8
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
9
Primary prostatic malignant giant cell tumor of soft parts. (1067447)
1976
10
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972

Variations for Malignant Giant Cell Tumor of Soft Parts

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Expression for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

Pathways for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Pathways related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ACTC1, DES
2
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.0ACTC1, DES
3
Show member pathways
9.0ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Compounds related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.5DES, S100B
2ccl444 2810.4S100B, DES
3bromodeoxyuridine449.3S100B, DES
4procollagen449.3ACTC1, DES
5methionine449.2S100B, DES
6biotin44 24 1111.2ACTC1, DES
7ethanol44 50 24 1112.2DES, S100B
8norepinephrine44 24 1111.1S100B, DES
9proline449.1S100B, DES
10acetylcholine44 50 28 24 1113.0S100B, DES
11orcein448.9S100B, ACTC1, DES
12s 100448.9DES, ACTC1, S100B
13reticulin448.9S100B, ACTC1, DES
14mucicarmine448.9DES, ACTC1, S100B
15b 723448.9S100B, ACTC1, DES
16hematoxylin448.9DES, ACTC1, S100B
17formaldehyde44 249.9S100B, ACTC1, DES
18imatinib44 50 1110.9DES, ACTC1, S100B
19glycogen44 249.9S100B, ACTC1, DES
20paraffin448.9DES, ACTC1, S100B
21iron44 249.9S100B, ACTC1, DES
22creatinine448.9DES, ACTC1, S100B
23progesterone44 28 61 24 1112.8S100B, ACTC1, DES
24testosterone44 61 24 1111.8S100B, ACTC1, DES
25steroid448.8S100B, ACTC1, DES
26vegf448.8DES, ACTC1, S100B
27oxygen44 249.8DES, ACTC1, S100B
28estrogen448.8DES, ACTC1, S100B
29retinoic acid44 249.7S100B, ACTC1, DES
30glucose448.7DES, ACTC1, S100B
31tyrosine448.7DES, ACTC1, S100B
32calcium44 50 24 1111.2DES, ACTC1, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.0ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Sources for Malignant Giant Cell Tumor of Soft Parts

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet