MCID: MLG018
MIFTS: 25

Malignant Giant Cell Tumor of Soft Parts malady

Categories: Cancer diseases

Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

Aliases & Descriptions for Malignant Giant Cell Tumor of Soft Parts:

Name: Malignant Giant Cell Tumor of Soft Parts 12 14
Malignant Giant Cell Neoplasm of Soft Parts 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5638
NCIt 47 C8380
SNOMED-CT 64 48460009
UMLS 69 C0334554

Summaries for Malignant Giant Cell Tumor of Soft Parts

MalaCards based summary : Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to malignant giant cell tumor and giant cell tumor. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is S100B (S100 Calcium Binding Protein B), and among its related pathways/superpathways are Lysosome and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include skin and prostate.

Related Diseases for Malignant Giant Cell Tumor of Soft Parts

Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor 30.5 ACP5 PTPRC
2 giant cell tumor 10.4
3 acute generalized exanthematous pustulosis 10.2 ACTC1 S100B
4 myoma 10.2 ACTC1 S100B
5 spleen angiosarcoma 10.2 ACTC1 S100B
6 conjunctival cancer 10.2 ACTC1 S100B
7 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.2 ACTC1 S100B
8 mediastinum liposarcoma 10.2 ACTC1 S100B
9 dyslexia 10.2 ACTC1 S100B
10 diarrhea, chronic, with villous atrophy 10.1 ACTC1 S100B
11 skin glomus tumor 10.1 CD68 S100B
12 pediculus humanus corporis infestation 10.1 CD68 S100B
13 episodic ataxia 10.1 ACTC1 CD68
14 uterine corpus leiomyomatosis 10.1 CD68 S100B
15 linear porokeratosis 10.1 ACTC1 CD68
16 cavernous sinus meningioma 10.1 LYZ S100B
17 tinea favosa 10.1 ACTC1 CD68
18 popliteal pterygium syndrome, bartsocas-papas type 10.1 ACTC1 S100B
19 monostotic fibrous dysplasia 10.1 CD68 S100B
20 juvenile xanthogranuloma 10.1 ACTC1 S100B
21 demyelinating disease 10.1 CD68 LYZ
22 maxillary sinus squamous cell carcinoma 10.1 CD68 LYZ
23 neutrophil immunodeficiency syndrome 10.1 ACTC1 S100B
24 liver rhabdomyosarcoma 10.1 CD68 LYZ
25 dentin dysplasia with sclerotic bones 10.1 LYZ S100B
26 pigmented villonodular synovitis 10.1 CD68 LYZ
27 mammary paget's disease 10.1 CD68 LYZ
28 mediastinum angiosarcoma 10.0 ACTC1 S100B
29 rosacea conjunctivitis 10.0 CD68 LYZ
30 neurofibroma 10.0 ACP5 CD68
31 malignant testicular leydig cell tumor 10.0 CD68 LYZ
32 bulbar polio 10.0 CD68 LYZ
33 cecum adenoma 10.0 ACTC1 S100B
34 juvenile astrocytoma 10.0 ACTC1 S100B
35 ampulla of vater mucinous adenocarcinoma 10.0 PTPRC S100B
36 alternating exotropia 10.0 CD68 LYZ
37 jewett-marshall bladder cancer 10.0 CD68 LYZ
38 malignant giant cell tumor of the tendon sheath 10.0 CD68 PTPRC
39 freemartinism 10.0 CD68 PTPRC
40 developmental coordination disorder 10.0 ACP5 PTPRC
41 teeth hard tissue disease 10.0 CD68 PTPRC
42 laryngeal adenoid cystic carcinoma 10.0 CD68 PTPRC
43 omodysplasia 2 10.0 ACTC1 PTPRC
44 choriocarcinoma of ovary 10.0 CD68 PTPRC
45 subacute delirium 10.0 CD68 PTPRC
46 lung benign neoplasm 10.0 ACTC1 PTPRC
47 malignant adult ependymoma 10.0 CD68 LYZ
48 cerebral arterial disease 10.0 CD68 PTPRC
49 adenosarcoma 10.0 ACTC1 S100B
50 adenosquamous colon carcinoma 10.0 LYZ PTPRC

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:



Diseases related to Malignant Giant Cell Tumor of Soft Parts

Symptoms & Phenotypes for Malignant Giant Cell Tumor of Soft Parts

Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

Drugs for Malignant Giant Cell Tumor of Soft Parts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3
Histamine Phosphate Phase 3 51-74-1 65513
4
Serotonin Phase 3 50-67-9 5202
5 Serotonin Agents Phase 3
6 Serotonin Antagonists Phase 3
7 Gastrointestinal Agents Phase 3
8 Neurotransmitter Agents Phase 3
9 Histamine Antagonists Phase 3
10 Histamine H1 Antagonists Phase 3
11 Dermatologic Agents Phase 3
12 Anti-Allergic Agents Phase 3
13 Antipruritics Phase 3
14
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
15 Protein Kinase Inhibitors Phase 2
16
Paclitaxel Approved, Vet_approved Phase 1 33069-62-4 36314
17 Albumin-Bound Paclitaxel Phase 1
18 Antimitotic Agents Phase 1
19 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
2 Trial of Dasatinib in Advanced Sarcomas Active, not recruiting NCT00464620 Phase 2
3 A Study of RO5509554 as Monotherapy and in Combination With Paclitaxel in Participants With Advanced Solid Tumors Active, not recruiting NCT01494688 Phase 1

Search NIH Clinical Center for Malignant Giant Cell Tumor of Soft Parts

Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

MalaCards organs/tissues related to Malignant Giant Cell Tumor of Soft Parts:

39
Skin, Prostate

Publications for Malignant Giant Cell Tumor of Soft Parts

Articles related to Malignant Giant Cell Tumor of Soft Parts:

id Title Authors Year
1
Malignant giant cell tumor of soft parts. ( 14997349 )
2004
2
Malignant giant cell tumor of soft parts in a mare. ( 14524631 )
2003
3
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. ( 10496598 )
1999
4
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. ( 8319177 )
1993
5
Malignant giant cell tumor of soft parts presenting as a skin tumor. ( 2658646 )
1989
6
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. ( 6465100 )
1984
7
The importance of recognizing malignant giant cell tumor of soft parts. ( 277073 )
1978
8
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. ( 195704 )
1977
9
Primary prostatic malignant giant cell tumor of soft parts. ( 1067447 )
1976
10
Malignant giant cell tumor of soft parts. An analysis of 32 cases. ( 5031245 )
1972

Variations for Malignant Giant Cell Tumor of Soft Parts

Expression for Malignant Giant Cell Tumor of Soft Parts

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

Pathways for Malignant Giant Cell Tumor of Soft Parts

Pathways related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.05 ACP5 CD68
2 10.69 CD68 PTPRC

GO Terms for Malignant Giant Cell Tumor of Soft Parts

Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 8.8 CD68 LYZ PTPRC

Sources for Malignant Giant Cell Tumor of Soft Parts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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