MCID: MLG018
MIFTS: 29

Malignant Giant Cell Tumor of Soft Parts malady

Cancer diseases category

Summaries for Malignant Giant Cell Tumor of Soft Parts

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MalaCards: Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to giant cell tumor and malignant giant cell tumor. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds procollagen and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide have been mentioned in the context of this disorder. Affiliated tissues include skin and prostate.

Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

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8Disease Ontology, 56SNOMED-CT, 60UMLS, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant giant cell tumor of soft parts 8
malignant giant cell neoplasm of soft parts 8


External Ids:

Disease Ontology8 DOID:5638
SNOMED-CT56 48460009
NCIt39 C8380

Related Diseases for Malignant Giant Cell Tumor of Soft Parts

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17GeneCards, 18GeneDecks
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Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 65)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.3S100B, DES, ACTC1
2malignant giant cell tumor10.9
3dermatofibrosarcoma10.4
4prostatitis10.4
5lymphangioleiomyomatosis10.0DES
6infantile myofibromatosis10.0DES
7fasciitis10.0ACTC1
8angiosarcoma10.0ACTC1
9lipoma10.0DES
10liposarcoma10.0DES
11fibrous meningioma10.0S100B
12teratoma10.0ACTC1
13adenoma10.0ACTC1
14perineurioma10.0S100B
15syringoma10.0S100B
16ganglioglioma10.0S100B
17hemangioblastoma10.0S100B
18meningioma10.0S100B
19paraganglioma10.0S100B
20histiocytosis10.0S100B
21hemangioma10.0ACTC1
22hypertrophic cardiomyopathy10.0ACTC1
23glomus tumor10.0ACTC1, DES
24angiomyolipoma10.0ACTC1, DES
25rhabdoid tumor10.0ACTC1, DES
26epithelioid leiomyosarcoma10.0ACTC1, DES
27pseudosarcomatous fibromatosis10.0DES, ACTC1
28spindle cell carcinoma10.0ACTC1, DES
29adenosarcoma10.0DES, ACTC1
30endometrial stromal sarcoma10.0DES, ACTC1
31embryonal rhabdomyosarcoma10.0DES, ACTC1
32abrikosov's tumor10.0ACTC1, DES
33desmoid tumor10.0ACTC1, DES
34benign mesothelioma10.0ACTC1, DES
35fibromatosis10.0ACTC1, DES
36tuberous sclerosis10.0S100B
37papilloma10.0ACTC1
38chondrosarcoma10.0DES, S100B
39sex cord-gonadal stromal tumor10.0DES, S100B
40noonan syndrome10.0ACTC1, DES
41myoepithelioma10.0ACTC1, S100B
42synovial sarcoma10.0S100B, DES
43granular cell tumor10.0S100B, DES
44peripheral primitive neuroectodermal tumor10.0DES, S100B
45malignant peripheral nerve sheath tumor10.0ACTC1, S100B
46chordoma10.0DES, S100B
47adenoid cystic carcinoma10.0S100B, ACTC1
48neurofibroma10.0S100B, ACTC1
49microphthalmia10.0ACTC1, S100B
50spindle cell sarcoma10.0ACTC1, DES, S100B

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:



Diseases related to malignant giant cell tumor of soft parts

Clinical Features for Malignant Giant Cell Tumor of Soft Parts

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Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

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Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

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32MalaCards
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MalaCards organs/tissues related to Malignant Giant Cell Tumor of Soft Parts:

32
Skin, Prostate

Animal Models for Malignant Giant Cell Tumor of Soft Parts or affiliated genes

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Publications for Malignant Giant Cell Tumor of Soft Parts

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50PubMed
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Articles related to Malignant Giant Cell Tumor of Soft Parts:

idTitleAuthorsYear
1
Malignant giant cell tumor of soft parts. (14997349)
2004
2
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
3
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. (10496598)
1999
4
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. (8319177)
1993
5
Malignant giant cell tumor of soft parts presenting as a skin tumor. (2658646)
1989
6
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
7
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
8
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
9
Primary prostatic malignant giant cell tumor of soft parts. (1067447)
1976
10
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972

Genetic Variations for Malignant Giant Cell Tumor of Soft Parts

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Expression for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

Pathways for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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4Cell Signaling Technology, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Pathways related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ACTC1, DES
2
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9.3ACTC1, DES
3
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9.3ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1procollagen449.5ACTC1, DES
23-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.4S100B, DES
3ccl444 2810.4DES, S100B
4biotin44 11 2411.2ACTC1, DES
5orcein448.9ACTC1, DES, S100B
6s 100448.9S100B, DES, ACTC1
7reticulin448.9ACTC1, DES, S100B
8mucicarmine448.9S100B, DES, ACTC1
9b 723448.9ACTC1, DES, S100B
10hematoxylin448.9ACTC1, DES, S100B
11formaldehyde44 249.8S100B, DES, ACTC1
12imatinib44 49 1110.8ACTC1, DES, S100B
13bromodeoxyuridine448.8DES, S100B
14glycogen44 249.8ACTC1, DES, S100B
15paraffin448.8S100B, DES, ACTC1
16iron44 249.8ACTC1, DES, S100B
17creatinine448.8ACTC1, DES, S100B
18progesterone44 59 28 11 2412.8ACTC1, DES, S100B
19testosterone44 59 11 2411.8ACTC1, DES, S100B
20steroid448.7S100B, DES, ACTC1
21vegf448.7ACTC1, DES, S100B
22oxygen44 249.7S100B, DES, ACTC1
23estrogen448.6ACTC1, DES, S100B
24retinoic acid44 249.6ACTC1, DES, S100B
25glucose448.5S100B, DES, ACTC1
26tyrosine448.5ACTC1, DES, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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16Gene Ontology
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Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.3ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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  • Antibodies
  • Proteins
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Sources for Malignant Giant Cell Tumor of Soft Parts

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet