MCID: MLG018
MIFTS: 21

Malignant Giant Cell Tumor of Soft Parts malady

Category: Cancer diseases

Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

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Aliases & Descriptions for Malignant Giant Cell Tumor of Soft Parts:

Name: Malignant Giant Cell Tumor of Soft Parts 10 12
 
Malignant Giant Cell Neoplasm of Soft Parts 10

Classifications:



External Ids:

Disease Ontology10 DOID:5638
SNOMED-CT59 48460009
NCIt42 C8380
UMLS65 C0334554

Summaries for Malignant Giant Cell Tumor of Soft Parts

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MalaCards based summary: Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to breast cancer and biotinidase deficiency. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is ACP5 (Acid Phosphatase 5, Tartrate Resistant), and among its related pathways are Lysosome and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include monocytes, and related mouse phenotype no phenotypic analysis.

Related Diseases for Malignant Giant Cell Tumor of Soft Parts

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Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1breast cancer10.2
2biotinidase deficiency10.2
3anencephaly10.2
4trachoma10.2
5cicatricial ectropion10.2
6thoracic aortic aneurysm10.2
7ectropion10.2
8aortic aneurysm10.2
9conjunctivitis10.2
10bacterial conjunctivitis10.2
11glioma10.2
12aneurysm10.2
13meibomian cyst10.1ACP5, CD68
14plexiform schwannoma10.1CD68, LYZ
15uterine corpus atypical polypoid adenomyoma10.1CD68, LYZ
16gastrointestinal tuberculosis10.0CD68, LYZ
17mucinous adenofibroma10.0CD68, LYZ
18staphyloenterotoxemia10.0ACP5, CD68
19primary angle-closure glaucoma10.0CD68, LYZ
20burning mouth syndrome10.0CD68, LYZ
21adult central nervous system teratoma10.0CD68, LYZ
22uterine corpus adenocarcinofibroma10.0CD68, LYZ
23integumentary system cancer10.0CD68, LYZ
24cervical incompetence10.0CD68, LYZ
25pigmented villonodular synovitis9.9CD68, PTPRC
26indolent systemic mastocytosis9.9CD68, PTPRC
27brain stem astrocytic neoplasm9.9CD68, PTPRC
28myocardial stunning9.9CD68, LYZ
29nervous system disease9.9CD68, PTPRC
30external ear squamous cell carcinoma9.9CD68, PTPRC
31central nervous system sarcoma9.9CD68, PTPRC
32pediatric fibrosarcoma9.9CD68, PTPRC
33dendritic cell sarcoma9.9LYZ, PTPRC
34diphtheria9.8CD68, PTPRC
35epidural spinal canal angiolipoma9.8LYZ, PTPRC
36al gazali aziz salem syndrome9.8CD68, LYZ
37skin carcinoma in situ9.8LYZ, PTPRC
38myelomeningocele9.8CD68, PTPRC
39lung leiomyosarcoma9.7CD68, PTPRC
40ductal carcinoma in situ9.7LYZ, PTPRC
41leukemia, acute myeloid9.6LYZ, PTPRC
42ovarian large-cell neuroendocrine carcinoma9.6CD68, PTPRC
43granulomatous dermatitis9.6CD68, LYZ, PTPRC
44leukemia9.5CD68, LYZ, PTPRC
45placenta accreta9.4LYZ, PTPRC
46rete testis neoplasm9.2ACP5, CD68, LYZ, PTPRC

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:



Diseases related to malignant giant cell tumor of soft parts

Symptoms for Malignant Giant Cell Tumor of Soft Parts

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Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

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Drugs for Malignant Giant Cell Tumor of Soft Parts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
CyproheptadineapprovedPhase 315129-03-32913
Synonyms:
1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine
1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine
129-03-3
4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine
4-(5-Dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine
4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidene
4-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine
4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine
4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine
41354-29-4
5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene
5-20-08-00500 (Beilstein Handbook Reference)
AC1L1ER8
AKOS004119847
Axoprol
BIDD:GT0324
BPBio1_000096
BPBio1_000155
BRD-K28143534-001-01-4
BRD-K28143534-003-03-6
BRN 1685976
BSPBio_000086
Biomol-NT_000131
C06935
CAS-969-33-5
CCRIS 5232
CHEBI:4046
CHEMBL516
CID2913
CYPROHEPTADINE
Ciproheptadina
Ciproheptadina [INN-Spanish]
Ciprovit
Ciprovit (TN)
Cypoheptadine
Cyproheptadiene
Cyproheptadin
Cyproheptadine
Cyproheptadine (INN)
 
Cyproheptadine Hcl
Cyproheptadine Hydrochloride
Cyproheptadine [INN:BAN]
Cyproheptadinum
Cyproheptadinum [INN-Latin]
D07765
DB00434
Dibenzosuberonone/Cyproheptadine
Dihexazin
Dronactin
EINECS 204-928-9
Eiproheptadine
Glutodina
HMS2090P20
HSDB 3048
L001016
LS-114933
Lopac-C-6022
Lopac0_000246
MK 141
MolPort-002-507-777
NCGC00015252-01
NCGC00015252-02
NCGC00015252-03
NCGC00015252-09
NCGC00024293-02
NCGC00024293-04
NCGC00024293-05
Oprea1_498140
PDSP1_001229
PDSP2_001213
Periactin
Periactine
Periactinol
Prestwick0_000103
Prestwick1_000103
Prestwick2_000103
Prestwick3_000103
SPBio_002025
STK802098
Tocris-0996
UNII-2YHB6175DO
Viternum
nchembio.559-comp10
2
Histamine PhosphateapprovedPhase 390651-74-165513
Synonyms:
1H-Imidazole-4-ethanamine, phosphate (1:2)
2-Imidazol-4-ylethylamine orthophosphoric acid (1:2)
4-(2-Aminoethyl)imidazole bis(dihydrogen phosphate)
4-(2-Aminoethyl)imidazole di-acid phosphate
4-2(2-Aminoethyl)Imidazole-Di-Acid Phosphate
51-74-1
53623-99-7
74-56-6
AC1L23E4
CID65513
D04445
DB00667
EINECS 200-118-4
 
H0147
Histamine Positive Skin Test Control
Histamine Positive skin test control
Histamine acid phosphate
Histamine biphosphate
Histamine dihydrogen phosphate
Histamine diphosphate
Histamine phosphate (1:2)
Histamine phosphate (TN)
Histamine phosphate (USP)
Histamine phosphate [USP]
Histamine positive
Histaminum
LS-78569
UNII-QWB37T4WZZ
3Neurotransmitter AgentsPhase 314795
4
SerotoninPhase 3314750-67-95202
Synonyms:
3-(2-Aminoethyl)-1H-indol-5-ol
3-(2-Aminoethyl)indol-5-ol
3-(b-Aminoethyl)-5-hydroxyindole
5-HT
5-HTA
5-Hydroxy-3-(b-aminoethyl)indole
 
5-Hydroxy-tryptamine
5-Hydroxyltryptamine
5-Hydroxytriptamine
5-Hydroxytryptamine
Antemovis
DS substance
Enteramin
Enteramine
5Serotonin AgentsPhase 32668
6Serotonin AntagonistsPhase 31175
7Anti-Allergic AgentsPhase 31312
8Histamine H1 AntagonistsPhase 3688
9AntipruriticsPhase 3619
10Histamine AntagonistsPhase 3826
11Dermatologic AgentsPhase 34555
12Gastrointestinal AgentsPhase 36401
13
histaminePhase 390675614-87-8, 51-45-6774
Synonyms:
.beta.-Imidazolyl-4-ethylamine
1H-Imidazole-4-ethanamine
1H-Imidazole-5-ethanamine
1avn
1qft
2-(1H-Imidazol-4-yl)ethanamine
2-(1H-Imidazol-4-yl)ethylamine
2-(1H-Imidazol-5-yl)ethanamine
2-(1H-Imidazol-5-yl)ethylamine
2-(1H-imidazol-4-yl)ethan-1-amine
2-(1H-imidazol-5-yl)ethanamine
2-(3H-Imidazol-4-yl)-ethylamine
2-(4-Imidazolyl)ethanamine
2-(4-Imidazolyl)ethylamine
2-Imidazol-4-yl-Ethylamine
2-Imidazol-4-ylethylamine
2-[4-Imidazolyl]ethylamine
4-(2-Aminoethyl)-1H-imidazole
4-(2-Aminoethyl)imidazole
4-Imidazoleethylamine
5-Imidazoleethylamine
51-45-6
53290_FLUKA
64422-25-9
924364-91-0
AC-13185
AC1L19ZT
AC1Q54BV
AC1Q54BW
AKOS000274386
ALBB-005968
BCBcMAP01_000250
BSPBio_001117
BSPBio_002124
Bio1_000487
Bio1_000976
Bio1_001465
Bio2_000389
Bio2_000869
C00388
CCRIS 6535
CHEBI:18295
CHEMBL90
CID774
D08040
DivK1c_000308
EINECS 200-100-6
Eramin
Ergamine
Ergotidine
F411C768-A159-4FC0-A195-291A08BB03AA
Free histamine
H7125_SIGMA
HMS1362G19
HMS1792G19
HMS1990G19
HSDB 3338
HSM
Histamine
Histamine (DCF)
Histamine Base
Histamine [USAN]
Histamine, Free Base
Histaminum
 
Histaminum (TN)
IDI1_000308
IDI1_002144
Imidazole-4-ethylamine
Istamina
Istamina [Italian]
KBio1_000308
KBio2_000457
KBio2_001325
KBio2_003025
KBio2_003893
KBio2_005593
KBio2_006461
KBio3_000853
KBio3_000854
KBio3_001344
KBioGR_000457
KBioGR_001580
KBioSS_000457
KBioSS_001325
L-Histamin base
L-Histamine
L-histamine
L000292
LS-75835
Lopac-H-7250
Lopac0_000595
MLS000069447
MolPort-001-785-597
MolPort-002-042-264
NCGC00015513-01
NCGC00015513-08
NCGC00093371-02
NCGC00093371-03
NCGC00093371-04
NCGC00093371-05
NINDS_000308
NSC 33792
NSC33792
SDCCGMLS-0066601.P001
SMP1_000151
SMR000059091
SPBio_000729
ST073926
STK346752
STOCK5S-55669
Spectrum2_000665
Spectrum3_000452
Spectrum4_000960
Spectrum5_000796
Spectrum_000845
Theramine
UNII-820484N8I3
WLN: T5M CNJ D2Z
ZERO/004089
[3H]histamine
b-Imidazolyl-4-ethylamine
beta-Aminoethylglyoxaline
beta-Aminoethylimidazole
beta-Aminothethylglyoxaline
beta-Imidazolyl-4-ethylamine
beta-aminothethylglyoxaline
bmse000744
histamine
nchembio.87-comp54
nchembio714-comp1
14
Dasatinibapproved, investigationalPhase 2268302962-49-83062316
Synonyms:
(18F)-N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
1N1
2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
302962-49-8
AC1MI3ET
AC1Q2P0C
AmbotzLS-1203
Anh. dasatinib
Anhydrous dasatinib
BCB03_000715
BMS 354825
BMS dasatinib
BMS-354825
BMS-354825, Sprycel, BMS354825, Dasatinib
BMS354825
C488369
CHEBI:49375
CHEMBL1421
CID3062316
D03658
DB01254
Dasatinib
Dasatinib (USAN)
Dasatinib (anh.)
Dasatinib [USAN]
Dasatinib anhydrous
Dasatinib, BMS 354825
 
Dasatinibum
EC-000.2122
EN002710
FT-0084503
I14-1972
Kinome_3650
LS-186641
LS-187028
LS-187773
MolPort-003-846-143
N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE
N-(2-CHLORO-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, monohydrate
N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide
NCGC00181129-01
NSC-732517
NSC732517
S1021_Selleck
SPRYCEL (TN)
Sprycel
Spyrcel
UNII-X78UG0A0RN
dasatinib
dasatinibum
nchembio.117-comp11
nchembio.162-comp4
nchembio.332-comp1
15Protein Kinase InhibitorsPhase 23162

Interventional clinical trials:

idNameStatusNCT IDPhase
1Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for CancerTerminatedNCT01132547Phase 3
2Trial of Dasatinib in Advanced SarcomasActive, not recruitingNCT00464620Phase 2

Search NIH Clinical Center for Malignant Giant Cell Tumor of Soft Parts

Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

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Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

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MalaCards organs/tissues related to Malignant Giant Cell Tumor of Soft Parts:

33
Monocytes

Animal Models for Malignant Giant Cell Tumor of Soft Parts or affiliated genes

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MGI Mouse Phenotypes related to Malignant Giant Cell Tumor of Soft Parts:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.5CD68, LYZ, PTPRC

Publications for Malignant Giant Cell Tumor of Soft Parts

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Articles related to Malignant Giant Cell Tumor of Soft Parts:

idTitleAuthorsYear
1
Management of Duodenal Atresia in the setting of Congenital Leukemia with Massive Hepatomegaly. (26023452)
2013
2
Prevalence of cervical intraepithelial neoplasia in patients with atypical squamous cells of undetermined significance from cervical pap smears in Beijing. (21941964)
2011
3
Prolonged hypercalcemia following resection of dysgerminoma: a case report. (20049088)
2009
4
Relapse of POEMS syndrome without increased level of VEGF. (19720532)
2009
5
MDM2 binding induces a conformational change in p53 that is opposed by heat-shock protein 90 and precedes p53 proteasomal degradation. (17363365)
2007
6
ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. (15525676)
2005
7
Reversible leukoencephalopathy associated with cerebral amyloid angiopathy. (14872042)
2004
8
Rare case of neuroendocrine small cell carcinoma of the endometrium with paraneoplastic membranous glomerulonephritis. (12841676)
2003
9
Angiotensin II type 1 receptor-153A/G and 1166A/C gene polymorphisms and increase in aortic stiffness with age in hypertensive subjects. (11288810)
2001
10
Role of dialysis modality in responses of blood monocytes and peritoneal macrophages to endotoxin stimulation. (8322772)
1993

Variations for Malignant Giant Cell Tumor of Soft Parts

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Expression for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

Pathways for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Pathways related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.4ACP5, CD68
29.1CD68, PTPRC

GO Terms for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dephosphorylationGO:00163119.1ACP5, PTPRC

Sources for Malignant Giant Cell Tumor of Soft Parts

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet