MCID: MLG018
MIFTS: 30

Malignant Giant Cell Tumor of Soft Parts malady

Cancer diseases category
Download this MalaCard

Summaries for Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to giant cell tumor and dermatofibrosarcoma protuberans. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ccl4 have been mentioned in the context of this disorder. Affiliated tissues include skin and prostate.

Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
8Disease Ontology, 62UMLS, 40NCIt, 58SNOMED-CT
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant giant cell tumor of soft parts 8
malignant giant cell neoplasm of soft parts 8


External Ids:

Disease Ontology8 DOID:5638
SNOMED-CT58 48460009
NCIt40 C8380

Related Diseases for Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1giant cell tumor31.3ACTC1, DES, S100B
2dermatofibrosarcoma protuberans30.5S100B, ACTC1, DES
3malignant giant cell tumor10.9
4dermatofibrosarcoma10.4
5prostatitis10.4
6fibrous meningioma10.1S100B
7syringoma10.1S100B
8histiocytosis10.1S100B
9ganglioglioma10.1S100B
10fasciitis10.1ACTC1
11infantile myofibromatosis10.1DES
12papilloma10.1ACTC1
13myoepithelioma10.0S100B, ACTC1
14malignant peripheral nerve sheath tumor10.0ACTC1, S100B
15neurofibroma10.0ACTC1, S100B
16adenoid cystic carcinoma10.0ACTC1, S100B
17microphthalmia10.0S100B, ACTC1
18granular cell tumor10.0S100B, DES
19sex cord-gonadal stromal tumor10.0DES, S100B
20glomus tumor10.0ACTC1, DES
21epithelioid leiomyosarcoma10.0DES, ACTC1
22pseudosarcomatous fibromatosis10.0ACTC1, DES
23spindle cell carcinoma10.0DES, ACTC1
24chordoma10.0DES, S100B
25desmoid tumor10.0DES, ACTC1
26adenosarcoma10.0ACTC1, DES
27endometrial stromal sarcoma10.0ACTC1, DES
28rhabdoid tumor10.0DES, ACTC1
29angiomyolipoma10.0ACTC1, DES
30embryonal rhabdomyosarcoma10.0DES, ACTC1
31synovial sarcoma10.0S100B, DES
32fibroma10.0DES, ACTC1
33fibromatosis10.0ACTC1, DES
34abrikosov's tumor10.0DES, ACTC1
35peripheral primitive neuroectodermal tumor10.0S100B, DES
36benign mesothelioma10.0ACTC1, DES
37chondrosarcoma10.0S100B, DES
38dilated cardiomyopathy10.0DES, ACTC1
39fibrosarcoma10.0ACTC1, DES
40spindle cell sarcoma10.0DES, ACTC1, S100B
41cutaneous fibrous histiocytoma10.0S100B, ACTC1, DES
42fibrous histiocytoma10.0ACTC1, DES, S100B
43hemangiopericytoma10.0DES, S100B, ACTC1
44malignant mixed mullerian tumor10.0DES, S100B, ACTC1
45smooth muscle tumor10.0DES, ACTC1, S100B
46malignant fibroxanthoma10.0S100B, DES, ACTC1
47pleomorphic adenoma10.0DES, S100B, ACTC1
48gastrointestinal stromal tumor9.9S100B, ACTC1, DES
49leiomyosarcoma9.9S100B, ACTC1, DES
50neurilemmoma9.9DES, ACTC1, S100B

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:



Diseases related to malignant giant cell tumor of soft parts

Symptoms for Malignant Giant Cell Tumor of Soft Parts

About this section

Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Malignant Giant Cell Tumor of Soft Parts

Search NIH Clinical Center for Malignant Giant Cell Tumor of Soft Parts

Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

About this section

Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Malignant Giant Cell Tumor of Soft Parts:

33
Skin, Prostate

Animal Models for Malignant Giant Cell Tumor of Soft Parts or affiliated genes

About this section

Publications for Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
52PubMed
See all sources

Articles related to Malignant Giant Cell Tumor of Soft Parts:

idTitleAuthorsYear
1
Malignant giant cell tumor of soft parts. (14997349)
2004
2
Malignant giant cell tumor of soft parts in a mare. (14524631)
2003
3
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. (10496598)
1999
4
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. (8319177)
1993
5
Malignant giant cell tumor of soft parts presenting as a skin tumor. (2658646)
1989
6
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. (6465100)
1984
7
The importance of recognizing malignant giant cell tumor of soft parts. (277073)
1978
8
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. (195704)
1977
9
Primary prostatic malignant giant cell tumor of soft parts. (1067447)
1976
10
Malignant giant cell tumor of soft parts. An analysis of 32 cases. (5031245)
1972

Variations for Malignant Giant Cell Tumor of Soft Parts

About this section

Expression for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

Pathways for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
50PathCards, 5Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 55Reactome
See all sources

Pathways related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0ACTC1, DES
2
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.0ACTC1, DES
3
Show member pathways
9.0ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
See all sources

Compounds related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.5DES, S100B
2ccl445 2910.4S100B, DES
3bromodeoxyuridine459.3DES, S100B
4procollagen459.3ACTC1, DES
5methionine459.2S100B, DES
6biotin45 24 1111.2ACTC1, DES
7ethanol45 51 24 1112.2S100B, DES
8norepinephrine45 24 1111.1DES, S100B
9proline459.1DES, S100B
10acetylcholine45 51 29 24 1113.0S100B, DES
11orcein458.9ACTC1, S100B, DES
12s 100458.9S100B, ACTC1, DES
13reticulin458.9DES, ACTC1, S100B
14mucicarmine458.9S100B, ACTC1, DES
15b 723458.9S100B, ACTC1, DES
16hematoxylin458.9DES, ACTC1, S100B
17formaldehyde45 249.9DES, ACTC1, S100B
18imatinib45 51 1110.9DES, S100B, ACTC1
19glycogen45 249.9S100B, DES, ACTC1
20paraffin458.9S100B, ACTC1, DES
21iron45 249.9DES, S100B, ACTC1
22creatinine458.9ACTC1, DES, S100B
23progesterone45 29 61 24 1112.8DES, ACTC1, S100B
24testosterone45 61 24 1111.8S100B, DES, ACTC1
25steroid458.8S100B, ACTC1, DES
26vegf458.8ACTC1, DES, S100B
27oxygen45 249.8DES, ACTC1, S100B
28estrogen458.8ACTC1, S100B, DES
29retinoic acid45 249.7S100B, ACTC1, DES
30glucose458.7ACTC1, DES, S100B
31tyrosine458.7ACTC1, S100B, DES
32calcium45 51 24 1111.2S100B, ACTC1, DES

GO Terms for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.0ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Malignant Giant Cell Tumor of Soft Parts

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet