MCID: MLG018
MIFTS: 16

Malignant Giant Cell Tumor of Soft Parts malady

Cancer category

Summaries for Malignant Giant Cell Tumor of Soft Parts

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MalaCards: Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to dermatofibrosarcoma protuberans and dermatofibrosarcoma. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cytoskeletal Signaling and Hypertrophic cardiomyopathy (HCM). The compounds procollagen and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide have been mentioned in the context of this disorder.

Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

Sources:
8Disease Ontology, 57SNOMED-CT, 61UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

malignant giant cell tumor of soft parts 8
malignant giant cell neoplasm of soft parts 8


External Ids:

Disease Ontology8 DOID:5638
SNOMED-CT57 48460009
NCIt40 C8380

Related Diseases for Malignant Giant Cell Tumor of Soft Parts

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17GeneCards, 18GeneDecks
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Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1dermatofibrosarcoma protuberans30.5S100B, DES, ACTC1
2dermatofibrosarcoma10.4
3lymphangioleiomyomatosis10.0DES
4infantile myofibromatosis10.0DES
5fasciitis10.0ACTC1
6angiosarcoma10.0ACTC1
7lipoma10.0DES
8liposarcoma10.0DES
9fibrous meningioma10.0S100B
10teratoma10.0ACTC1
11adenoma10.0ACTC1
12perineurioma10.0S100B
13syringoma10.0S100B
14ganglioglioma10.0S100B
15hemangioblastoma10.0S100B
16meningioma10.0S100B
17paraganglioma10.0S100B
18histiocytosis10.0S100B
19hemangioma10.0ACTC1
20hypertrophic cardiomyopathy10.0ACTC1
21glomus tumor10.0ACTC1, DES
22angiomyolipoma10.0ACTC1, DES
23rhabdoid tumor10.0ACTC1, DES
24epithelioid leiomyosarcoma10.0ACTC1, DES
25pseudosarcomatous fibromatosis10.0DES, ACTC1
26spindle cell carcinoma10.0ACTC1, DES
27adenosarcoma10.0DES, ACTC1
28endometrial stromal sarcoma10.0DES, ACTC1
29embryonal rhabdomyosarcoma10.0DES, ACTC1
30abrikosov's tumor10.0ACTC1, DES
31desmoid tumor10.0ACTC1, DES
32benign mesothelioma10.0ACTC1, DES
33fibromatosis10.0ACTC1, DES
34tuberous sclerosis10.0S100B
35papilloma10.0ACTC1
36chondrosarcoma10.0DES, S100B
37sex cord-gonadal stromal tumor10.0DES, S100B
38noonan syndrome10.0ACTC1, DES
39myoepithelioma10.0ACTC1, S100B
40synovial sarcoma10.0S100B, DES
41granular cell tumor10.0S100B, DES
42peripheral primitive neuroectodermal tumor10.0DES, S100B
43malignant peripheral nerve sheath tumor10.0ACTC1, S100B
44chordoma10.0DES, S100B
45adenoid cystic carcinoma10.0S100B, ACTC1
46neurofibroma10.0S100B, ACTC1
47microphthalmia10.0ACTC1, S100B
48spindle cell sarcoma10.0ACTC1, DES, S100B
49cutaneous fibrous histiocytoma10.0S100B, DES, ACTC1
50fibrous histiocytoma10.0ACTC1, DES, S100B

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:



Diseases related to malignant giant cell tumor of soft parts

Clinical Features for Malignant Giant Cell Tumor of Soft Parts

Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

Animal Models for Malignant Giant Cell Tumor of Soft Parts or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Malignant Giant Cell Tumor of Soft Parts

Genetic Variations for Malignant Giant Cell Tumor of Soft Parts

Expression for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

Pathways for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Sources:
4Cell Signaling Technology, 30KEGG, 38NCBI BioSystems Database, 54Reactome
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Pathways related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ACTC1, DES
2
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9.3ACTC1, DES
3
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9.3ACTC1, DES

Compounds for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

(show all 26)
idCompoundScoreTop Affiliating Genes
1procollagen459.5ACTC1, DES
23-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.4S100B, DES
3ccl445 2910.4DES, S100B
4biotin45 11 2411.2ACTC1, DES
5orcein458.9ACTC1, DES, S100B
6s 100458.9S100B, DES, ACTC1
7reticulin458.9ACTC1, DES, S100B
8mucicarmine458.9S100B, DES, ACTC1
9b 723458.9ACTC1, DES, S100B
10hematoxylin458.9ACTC1, DES, S100B
11formaldehyde45 249.8S100B, DES, ACTC1
12imatinib45 50 1110.8ACTC1, DES, S100B
13bromodeoxyuridine458.8DES, S100B
14glycogen45 249.8ACTC1, DES, S100B
15paraffin458.8S100B, DES, ACTC1
16iron45 249.8ACTC1, DES, S100B
17creatinine458.8ACTC1, DES, S100B
18progesterone45 60 29 11 2412.8ACTC1, DES, S100B
19testosterone45 60 11 2411.8ACTC1, DES, S100B
20steroid458.7S100B, DES, ACTC1
21vegf458.7ACTC1, DES, S100B
22oxygen45 249.7S100B, DES, ACTC1
23estrogen458.6ACTC1, DES, S100B
24retinoic acid45 249.6ACTC1, DES, S100B
25glucose458.5S100B, DES, ACTC1
26tyrosine458.5ACTC1, DES, S100B

GO Terms for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

Sources:
16Gene Ontology
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Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.3ACTC1, DES

Products for genes affiliated with Malignant Giant Cell Tumor of Soft Parts

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  • Proteins
  • Lysates
  • Antibodies

Sources for Malignant Giant Cell Tumor of Soft Parts

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet