MCID: MLG068
MIFTS: 66

Malignant Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Malignant Glioma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises... more...

MalaCards: Malignant Glioma, also known as glioma, is related to astrocytoma and herpes simplex. An important gene associated with Malignant Glioma is LGI1 (leucine-rich, glioma inactivated 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and endothelial, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology:8 A cell type cancer that has material basis in glial cells and is located in brain or located in spine.

Description from OMIM:46 137800

Aliases & Classifications for Malignant Glioma

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 46OMIM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

malignant glioma 8 10 44 30 60
glioma 8 42 44 60
glioma, malignant, no icd-o subtype 8
malignant glioma - category 8
malignant neuroglial tumor 8
glioma, malignant 8
neuroglial tumor 8
glial cell tumor 8
glioma, nos 8
glioma nos 8
gliomas 8


Related Diseases for Malignant Glioma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Glioma family:

Benign Glioma

Diseases related to Malignant Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.6TNFSF10, TNFRSF6B, MAGED4B, IL13, IL13RA2, GFAP
2herpes simplex30.5TNFRSF6B, TNFSF10
3brain cancer30.4TNFSF10, LGI1, MSI1, TERC, GFAP, IL13RA2
4glioblastoma multiforme30.4TNFSF10, IL13, IL13RA1, IL13RA2, GFAP, LGI1
5medulloblastoma30.2GFAP, IL13RA2, TNFSF10
6adenocarcinoma30.0BNIP3, TNFSF10, TNFRSF6B, FAS, IL13RA2, ACSL5
7breast cancer30.0BNIP3, TNFSF10, FABP7, FAS, PPAT, TERC
8adenoma30.0TERC, ACSL5
9lung cancer30.0BNIP3, TNFSF10, FAS, PPAT, TERC
10melanoma29.9TNFSF10, FAS, PPAT, MAGED4B, TERC
11multiple sclerosis29.6TNFSF10, IL13, GFAP
12subependymal giant cell astrocytoma29.6GFAP
13neuroblastoma10.7
14optic nerve glioma10.7
15brain glioma10.7
16chordoid glioma10.6
17neurofibromatosis10.5
18third ventricle chordoid glioma10.5
19spinal cord glioma10.5
20mixed glioma10.4
21oligodendroglioma10.4
22differentiating neuroblastoma10.3
23glioma somatic10.3
24brain edema10.2
25cerebritis10.2
26childhood brain stem glioma10.2
27leukemia10.2
28subependymal glioma10.2
29thyroiditis10.2
30retinoblastoma10.2
31cholera10.1
32arteriovenous malformation10.1
33neuronitis10.1
34lymphopenia10.1
35malignant ependymoma10.1
36meningioma10.1
37meningitis10.1
38adult brainstem mixed glioma10.1
39gliosarcoma10.1
40optic pathway glioma10.1
41central nervous system lymphoma10.1
42vaccinia10.1
43arachnoiditis10.1
44childhood optic nerve glioma10.1
45acoustic neuroma10.1
46hepatocellular carcinoma10.1
47neuroma10.1
48pertussis10.1
49rhabdomyosarcoma10.1
50syringomyelia10.0

Graphical network of the top 20 diseases related to Malignant Glioma:



Diseases related to malignant glioma

Clinical Features for Malignant Glioma

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Sources:
46OMIM
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Clinical features from OMIM:

137800

Drugs & Therapeutics for Malignant Glioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Glioma

Drug clinical trials:

Search ClinicalTrials for Malignant Glioma

Search NIH Clinical Center for Malignant Glioma

Search CenterWatch for Malignant Glioma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malignant Glioma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malignant Glioma:
ALD-451, bone marrow-derived cells for malignant glioma
Embryonic/Adult Cultured Cells Related to Malignant Glioma:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905

Genetic Tests for Malignant Glioma

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Anatomical Context for Malignant Glioma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Malignant Glioma:

32
Brain, Endothelial, Bone, T cells, Monocytes, Spinal cord, Bone marrow, Colon, Prostate, Nk cells, Cortex, Testes, Myeloid, Breast, Skeletal muscle, Lung, Liver, Dentritic cells

FMA organs/tissues related to Malignant Glioma:

14
Brain or

Animal Models for Malignant Glioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.2MSI1, BNIP3, SOX11, TNFSF10, FABP7, FAS
2MP:001076812.1EFEMP1, PPME1, FAS, TNFSF10, SOX11, IL13
3MP:000538711.8SOX11, TNFSF10, FAS, EFEMP1, IL13, IL13RA1
4MP:000539711.6BNIP3, SOX11, TNFSF10, FAS, EFEMP1, IL13
5MP:000538111.2SOX11, FAS, EFEMP1, IL13, FPR1, GFAP
6MP:000118611.0LGI1, TERC, EFEMP1, FAS
7MP:000538810.9SOX11, FAS, PPME1, IL13, IL13RA1, TERC

Publications for Malignant Glioma

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50PubMed
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Articles related to Malignant Glioma:

(show top 50)    (show all 1111)
idTitleAuthorsYear
1
Prognostic impact of the isocitrate dehydrogenase 1 single-nucleotide polymorphism rs11554137 in malignant gliomas. (23184331)
2013
2
Treatment of newly diagnosed malignant glioma in the elderly people: new trials that impact therapy. (24246204)
2013
3
A peptide-mediated targeting gene delivery system for malignant glioma cells. (24101872)
2013
4
Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor I+2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele. (22424217)
2012
5
Stratification according to HGG-IMMUNO RPA model predicts outcome in a large group of patients with relapsed malignant glioma treated by adjuvant postoperative dendritic cell vaccination. (22565485)
2012
6
Malignant glioma grade 3 and 4: how relevant is timing of radiotherapy? (22244251)
2012
7
The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. (21397859)
2011
8
Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells. (21470923)
2011
9
Immunotherapy approaches for malignant glioma from 2007 to 2009. (20424975)
2010
10
Investigation of a plasmid containing a novel immunotoxin VEGF165-PE38 gene for antiangiogenic therapy in a malignant glioma model. (20127864)
2010
11
Circulating endothelial progenitor cells in malignant gliomas. (19522573)
2010
12
p53 in malignant glioma: 20 years later and still much to learn. (20406892)
2010
13
Capsaicin sensitizes malignant glioma cells to TRAIL-mediated apoptosis via DR5 upregulation and survivin downregulation. (19939880)
2010
14
First-line treatment of malignant glioma with carmustine implants followed by concomitant radiochemotherapy: a multicenter experience. (20706757)
2010
15
Incorporation of endothelial progenitor cells into the neovasculature of malignant glioma xenograft. (19052696)
2009
16
Treatment of malignant gliomas with TGF-beta2 antisense oligonucleotides. (19895249)
2009
17
Effects of simulated microgravity on proliferation and chemosensitivity in malignant glioma cells. (19628020)
2009
18
Expression analysis of the autosomal recessive primary microcephaly genes MCPH1 (microcephalin) and MCPH5 (ASPM, abnormal spindle-like, microcephaly associated) in human malignant gliomas. (18636190)
2008
19
EGFR tyrosine kinase inhibition radiosensitizes and induces apoptosis in malignant glioma and childhood ependymoma xenografts. (18386816)
2008
20
Glucose metabolites, glutamate and glycerol in malignant glioma tumours during radiotherapy. (18563297)
2008
21
Association of telomerase gene hTERT polymorphism and malignant gliomas. (17410334)
2007
22
Identification of hypoxia-induced genes in a malignant glioma cell line (U-251) by cDNA microarray analysis. (17486380)
2007
23
Role of p16 and p14ARF in radio- and chemosensitivity of malignant gliomas. (16786135)
2006
24
PCTAIRE3: a putative mediator of growth arrest and death induced by CTS-1, a dominant-positive p53-derived synthetic tumor suppressor, in human malignant glioma cells. (16276348)
2006
25
Autophagic cell death of malignant glioma cells induced by a conditionally replicating adenovirus. (16670388)
2006
26
Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus. (15015777)
2004
27
Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis. (15358139)
2004
28
Characterization of gastrin-induced cytostatic effect on cell proliferation in experimental malignant gliomas. (12657185)
2003
29
Increased invasive capacity of connexin43-overexpressing malignant glioma cells. (14705732)
2003
30
Interleukin-13 receptor-directed cytotoxin for malignant glioma therapy: from bench to bedside. (14649884)
2003
31
The role of thrombin in the neo-vascularization of malignant gliomas: an intrinsic modulator for the up-regulation of vascular endothelial growth factor. (11956584)
2002
32
Effects of a novel synthetic retinoid on malignant glioma in vitro: inhibition of cell proliferation, induction of apoptosis and differentiation. (11267863)
2001
33
Radiosensitization of malignant glioma cells through overexpression of dominant-negative epidermal growth factor receptor. (11297265)
2001
34
Molecular targeting of malignant gliomas with novel multiply-mutated interleukin 13-based cytotoxins. (11418305)
2001
35
Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation. (10427138)
1999
36
Gemcitabine cytotoxicity of human malignant glioma cells: modulation by antioxidants, BCL-2 and dexamethasone. (9988115)
1999
37
Function of aberrant EGFR in malignant gliomas. (9879464)
1998
38
BCL-2 family protein expression in human malignant glioma: a clinical-pathological correlative study. (9562325)
1998
39
Hyaluronic acid binding capacity of malignant glioma cells. (9568102)
1998
40
Prognostic factors in malignant glioma: influence of the overexpression of oncogene and tumor-suppressor gene products on survival. (9266437)
1997
41
Soluble TNF-alpha receptors are constitutively shed and downregulate adhesion molecule expression in malignant gliomas. (9143267)
1997
42
Antiproliferative effect of c-myc antisense phosphorothioate oligodeoxynucleotides in malignant glioma cells. (9316053)
1997
43
The relationship between TP53 mutations and overexpression of p53 and prognosis in malignant gliomas of childhood. (9000573)
1997
44
Chemotherapy of human malignant glioma: prevention of efficacy by dexamethasone? (9191791)
1997
45
Amplification at 12q13-14 in human malignant gliomas is frequently accompanied by loss of heterozygosity at loci proximal and distal to the amplification site. (7850781)
1995
46
Expression and localization of messenger RNA and protein for monocyte chemoattractant protein-1 in human malignant glioma. (8189261)
1994
47
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. (8504413)
1993
48
Basic research for interferon gene therapy against malignant glioma]. (1598130)
1992
49
Correlation of basic fibroblast growth factor expression levels with the degree of malignancy and vascularity in human gliomas. (1564542)
1992
50
Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. (2352010)
1990

Genetic Variations for Malignant Glioma

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Expression for genes affiliated with Malignant Glioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Glioma

Search GEO for disease gene expression data for Malignant Glioma.

Pathways for genes affiliated with Malignant Glioma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Malignant Glioma

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Malignant Glioma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1vegf4411.7GFAP, FPR1, IL13RA1, IL13, FAS, TNFSF10
2retinoic acid44 2412.7TNFSF10, FABP7, FAS, IL13, FPR1, GFAP
3phosphatidylinositol4411.6BNIP3, TNFSF10, TNFRSF6B, FAS, IL13, FPR1
4nitric oxide44 11 2413.6BNIP3, TNFSF10, FAS, IL13, IL13RA1, FPR1
5sb 20358044 5912.5BNIP3, TNFSF10, FAS, IL13, FPR1
6glutamine4411.5TNFSF10, FAS, PPAT, IL13, GFAP
7fatty acid4411.5BNIP3, TNFSF10, FABP7, FAS, ACSL5
8cisplatin44 49 59 1114.4TNFSF10, FAS, PPAT, GFAP, TERC
9thymidine44 2412.4TERC, GFAP, IL13RA1, IL13, FAS
10ionomycin4411.3TNFSF10, FAS, IL13, FPR1
115-aza-2deoxycytidine4411.3MAGED4B, FAS, TNFSF10, BNIP3
125fluorouracil4411.3BNIP3, TNFSF10, FAS, TERC
13indomethacin44 59 28 1114.2FPR1, IL13, FAS, TNFSF10
14dutp4411.2TNFSF10, FAS, GFAP
15butyrate4411.2TERC, GFAP, FAS, TNFSF10
16glutamate4411.2FABP7, PPAT, GFAP
17paclitaxel44 49 1113.2BNIP3, TNFSF10, FAS, GFAP
18ifn-alpha4411.2IL13, FAS, TNFSF10
19doxycycline44 1112.2GFAP, IL13, TNFSF10
20rottlerin4411.1IL13, FAS, TNFSF10
21cyclosporin h44 2812.1FPR1, IL13
22tetracycline44 1112.1TNFSF10, FAS, GFAP
23pd 98,0594411.0GFAP, IL13, FAS, TNFSF10
24adpribose4411.0TERC, FAS, TNFSF10
25propentofylline4411.0FAS, GFAP
26sp 60012544 5912.0IL13, FAS, TNFSF10
27alpha-galactosylceramide4411.0IL13, TNFSF10
28wortmannin4411.0TNFSF10, FAS, IL13, FPR1
29cytarabine44 49 1113.0TNFSF10, FAS, GFAP
30doxorubicin44 49 1112.9TERC, IL13, FAS, TNFSF10
31adriamycin4410.8TERC, FAS, TNFSF10
32dexamethasone44 49 28 1113.8TNFSF10, FAS, IL13, FPR1, GFAP

GO Terms for genes affiliated with Malignant Glioma

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16Gene Ontology
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Cellular components related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.2LGI1, IL13RA2, IL13, EFEMP1, TNFRSF6B, TNFSF10

Biological processes related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.2TNFSF10, FAS, IL13, IL13RA2, FPR1, LRRN2
2cellular response to mechanical stimulusGO:07126010.7BNIP3, FAS, IL13
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.4TNFSF10, FAS

Molecular functions related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:00489610.7IL13RA2, IL13RA1
2receptor activityGO:00487210.7LRRN2, FPR1, FAS, TNFRSF6B

Products for genes affiliated with Malignant Glioma

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Sources for Malignant Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet