MCID: MLG068
MIFTS: 69

Malignant Glioma malady

Rare diseases, Cancer diseases, Neuronal diseases categories
Download this MalaCard

Summaries for Malignant Glioma

About this section


Fully expand this MalaCard
Wikipedia:65 A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises... more...

MalaCards based summary: Malignant Glioma, also known as glioma, is related to herpes simplex and brain cancer. An important gene associated with Malignant Glioma is FABP7 (fatty acid binding protein 7, brain), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Apoptosis. The compounds cyclosporin h and concanamycin a have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and endothelial, and related mouse phenotypes are vision/eye and integument.

Disease Ontology:8 A cell type cancer that has material basis in glial cells and is located in brain or located in spine.

Description from OMIM:46 137800

Aliases & Classifications for Malignant Glioma

About this section

Malignant Glioma, Aliases & Descriptions:

Name: Malignant Glioma 30 8 10 44 62
Glioma 8 42 44 62
Malignant Glioma - Category 8 62
Malignant Neuroglial Tumor 8 62
Neuroglial Tumor 8 62
Gliomas 8 62
 
Glioma, Malignant, No Icd-O Subtype 8
Tumor, Glial Cell 62
Glioma, Malignant 8
Glial Cell Tumor 8
Glioma, Nos 8
Glioma Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Related Diseases for Malignant Glioma

About this section

Diseases in the Malignant Glioma family:

Benign Glioma

Diseases related to Malignant Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 321)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex30.7ISG20, TNFRSF6B, TNFSF10
2brain cancer30.6IL13, GFAP
3medulloblastoma30.5IL13RA2, TNFSF10, GFAP, NUDT6
4subependymal giant cell astrocytoma30.4GFAP
5retinoblastoma30.1TERC, GFAP, DCT, CXADR
6lung cancer30.1CXADR, FAS, TNFSF10, TERC
7gastric adenocarcinoma30.0FASLG, FAS, TERC
8astrocytoma30.0TERC, GFAP, TNFSF10, TNFRSF6B, FASLG, CXADR
9stomach cancer29.9FASLG, FAS, TNFRSF6B, TERC
10multiple sclerosis29.8GFAP, TNFSF10, FASLG, IL13
11pancreatic cancer29.8TERC, BNIP3, TNFSF10, TNFRSF6B, FASLG
12glioblastoma multiforme29.7GFAP, TNFSF10, DCT, FASLG, CXADR, IL13RA2
13leukemia29.5TERC, NUDT6, TNFSF10, ISG20, FAS, FASLG
14ovarian cancer29.5TERC, TNFSF10, FAS, FASLG, CXADR
15breast cancer29.3TERC, BNIP3, NUDT6, TNFSF10, ISG20, FAS
16adenocarcinoma29.1TERC, BNIP3, NUDT6, TNFSF10, TNFRSF6B, FAS
17prostate cancer28.9TERC, BNIP3, NUDT6, TNFSF10, FAS, FASLG
18glioblastoma28.9IL13RA1, IL13, MAGED4B, FPR1, IL13RA2, MSI1
19melanoma28.9TERC, NUDT6, TNFSF10, ISG20, DCT, FAS
20brain glioma10.9
21neuroblastoma10.8
22optic nerve glioma10.8
23brain stem glioma10.7
24chordoid glioma10.7
25endotheliitis10.7
26neurofibromatosis10.6
27angiocentric glioma10.6
28spinal cord glioma10.5
29mixed glioma10.5
30oligodendroglioma10.4
31hypoxia10.4
32grade iii astrocytoma10.3IL13RA1, TNFSF10, GFAP
33silicosis10.3FASLG, FAS
34brain edema10.3
35thyroiditis10.3
36encephalocele10.3
37glioma somatic10.3
38vogt-koyanagi-harada disease10.3FAS, FASLG
39toxic epidermal necrolysis10.3FAS, FASLG
40third ventricle chordoid glioma10.3
41lymphomatoid papulosis10.3FAS, FASLG
42allergic asthma10.3IL13, IL13RA1, IL13RA2
43cerebritis10.3
44cowpox10.3FAS, TNFSF10
45differentiating neuroblastoma10.2
46childhood brain stem glioma10.2
47stevens-johnson syndrome10.2FASLG, FAS
48autoimmune lymphoproliferative syndrome10.2FAS, FASLG
49idiopathic pulmonary fibrosis10.2TERC, FASLG, IL13
50bladder carcinoma10.2TNFSF10, NUDT6, TERC

Graphical network of the top 20 diseases related to Malignant Glioma:



Diseases related to malignant glioma

Symptoms for Malignant Glioma

About this section


Clinical features from OMIM:

137800

Drugs & Therapeutics for Malignant Glioma

About this section

Drug clinical trials:

Search ClinicalTrials for Malignant Glioma

Search NIH Clinical Center for Malignant Glioma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malignant Glioma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malignant Glioma:
ALD-451, bone marrow-derived cells for malignant glioma
Embryonic/Adult Cultured Cells Related to Malignant Glioma:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905

Genetic Tests for Malignant Glioma

About this section

Anatomical Context for Malignant Glioma

About this section

MalaCards organs/tissues related to Malignant Glioma:

32
Brain, Endothelial, Bone, T cells, Monocytes, Bone marrow, Prostate, Cortex, Skeletal muscle, Colon, Liver, Lung, Breast, Testes, Dentritic cells, Nk cells, Neutrophil

FMA organs/tissues related to Malignant Glioma:

14
Brain or

Animal Models for Malignant Glioma or affiliated genes

About this section

Publications for Malignant Glioma

About this section

Articles related to Malignant Glioma:

(show top 50)    (show all 1033)
idTitleAuthorsYear
1
Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis. (24220141)
2013
2
Prognostic value of isocitrate dehydrogenase 1, O6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients. (24160898)
2013
3
Re-irradiation in recurrent malignant glioma: prognostic value of [18F]FET-PET. (23054562)
2012
4
Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor I+2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele. (22424217)
2012
5
Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma. (22844129)
2012
6
A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma. (22832897)
2012
7
Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. (21173573)
2011
8
Cell surface receptors in malignant glioma. (21522029)
2011
9
O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. (21365007)
2011
10
Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. Clinical article. (20964595)
2011
11
Papillary endothelial hyperplasia presenting as recurrent malignant glioma. (20740304)
2011
12
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells. (20946108)
2011
13
Human malignant glioma cells expressing functional formylpeptide receptor recruit endothelial progenitor cells for neovascularization. (20933627)
2010
14
MGMT promoter methylation in malignant gliomas: ready for personalized medicine? (19997073)
2010
15
Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma. (20702765)
2010
16
Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. (20479404)
2010
17
Hoechst 33342 induces radiosensitization in malignant glioma cells via increase in mitochondrial reactive oxygen species. (20540663)
2010
18
High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (20555079)
2010
19
Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2. (19398149)
2009
20
Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas. (19686285)
2009
21
Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo. (19277041)
2009
22
Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation. (19199463)
2009
23
yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients. (19900287)
2009
24
Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma. (17924059)
2008
25
Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma. (18948169)
2008
26
Molecular targeted therapies and chemotherapy in malignant gliomas. (17906459)
2007
27
The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications. (17373877)
2007
28
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. (16818640)
2006
29
Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy. (16700620)
2006
30
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells. (16516855)
2006
31
Malignant glioma: the involvement of loss of allelic heterozygosity and PTEN mutations in a group of Malay patients. (16124450)
2005
32
Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Ralpha2. (15805299)
2005
33
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. (15205343)
2004
34
Expression of mutant non-cleavable Fas ligand on retrovirus packaging cells causes apoptosis of immunocompetent cells and improves prodrug activation gene therapy in a malignant glioma model. (12888123)
2003
35
Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. (12651152)
2003
36
PTEN mutations in malignant gliomas and their relation with meningeal gliomatosis. (11678426)
2001
37
Monitoring activation of ribonuclease L by 2',5'-oligoadenylates using purified recombinant enzyme and intact malignant glioma cells. (11586885)
2001
38
A novel role for the urokinase-type plasminogen activator receptor in apoptosis of malignant gliomas. (10853019)
2000
39
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells. (10569804)
1999
40
Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of experimental intracranial human malignant glioma. (10533721)
1999
41
Irradiation induced clonogenic cell death of human malignant glioma cells does not require CD95/CD95L interactions. (10697547)
1999
42
Soluble CD95 (Fas/APO-1) in malignant glioma: (no) implications for CD95-based immunotherapy? (10066095)
1998
43
Interferon-alpha enhances CD95L-induced apoptosis of human malignant glioma cells. (9670853)
1998
44
Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. (9484714)
1998
45
Biological profiles of malignant gliomas]. (7675550)
1995
46
Modulation of O6-methylguanine-DNA methyltransferase-mediated nimustine resistance in recurrent malignant gliomas by streptozotocin--a preliminary report. (7763050)
1995
47
Basic research for interferon gene therapy against malignant glioma]. (1598130)
1992
48
Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. (2352010)
1990
49
Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro. (2224848)
1990
50
Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas. (2814622)
1989

Variations for Malignant Glioma

About this section

Expression for genes affiliated with Malignant Glioma

About this section
Expression patterns in normal tissues for genes affiliated with Malignant Glioma

Search GEO for disease gene expression data for Malignant Glioma.

Pathways for genes affiliated with Malignant Glioma

About this section

Pathways related to Malignant Glioma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0FASLG, FAS
2
Show member pathways
9.8FASLG, FAS, TNFSF10
3
Show member pathways
TRAIL signaling pathway37
9.8TNFSF10, FASLG, FAS
4
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.8FASLG, FAS, TNFSF10
5
Show member pathways
9.8TNFSF10, FASLG, FAS
6
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.8FASLG, FAS, TNFRSF6B
7
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
9.7FASLG, TNFSF10, BNIP3
8
Show member pathways
Type III interferon signaling37
9.7IL13, IL13RA1, IL13RA2
99.6FASLG, FAS, TNFSF10, TNFRSF6B
10
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway37
Apoptosis Modulation by HSP7037
HIV-1 Nef- Negative effector of Fas and TNF-alpha37
9.6TNFRSF6B, TNFSF10, FAS, FASLG
11
Show member pathways
9.6TNFRSF6B, FASLG, FAS, TNFSF10
12
Show member pathways
9.6TNFSF10, FAS, FASLG, IL13
13
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.2TNFRSF6B, BNIP3, TNFSF10, FAS, FASLG
14
Show member pathways
9.2IL13, TNFSF10, IL13RA2, NUDT6, IL13RA1
15
Show member pathways
9.2NUDT6, IL13, TNFSF10, IL13RA2, IL13RA1
16
Show member pathways
9.2IL13RA1, IL13RA2, NUDT6, TNFSF10, IL13
17
Show member pathways
9.2FASLG, CXADR, IL13, FAS
18
Show member pathways
8.8TNFSF10, IL13RA1, IL13RA2, FASLG, FAS, TNFRSF6B
19
Show member pathways
8.3IL13RA1, IL13RA2, SOX11, TNFRSF6B, TNFSF10, GFAP

Compounds for genes affiliated with Malignant Glioma

About this section

Compounds related to Malignant Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1cyclosporin h44 2811.3IL13, FPR1
2concanamycin a44 6111.1TNFSF10, FAS, FASLG
33-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4410.0FAS, FASLG, TNFSF10
4dutp4410.0TNFSF10, GFAP, FAS, FASLG
5adpribose4410.0TNFSF10, TERC, FASLG, FAS
6ifn-alpha4410.0FAS, FASLG, IL13, TNFSF10
7tetracycline44 1111.0GFAP, TNFSF10, FAS, FASLG
8rottlerin4410.0FAS, TNFSF10, FASLG, IL13
9adriamycin4410.0FAS, FASLG, TNFSF10, TERC
10suberoylanilide hydroxamic acid4410.0TNFSF10, FAS, FASLG
11sp 60012544 6110.9TNFSF10, FAS, FASLG, IL13
12cytarabine44 50 1111.9GFAP, FAS, FASLG, TNFSF10
13streptozotocin449.9NUDT6, GFAP, TNFSF10
14dmso449.8NUDT6, FPR1, TNFSF10, TERC
15bromodeoxyuridine449.8FASLG, GFAP, NUDT6, IL13
16ionomycin449.8FAS, FPR1, FASLG, TNFSF10, IL13
17doxycycline44 1110.8FASLG, IL13, TNFSF10, GFAP, NUDT6
18indomethacin44 28 61 1112.8FASLG, TNFSF10, IL13, FAS, FPR1
19agar449.8FAS, GFAP, FASLG, NUDT6, TERC
202-methoxyestradiol44 61 2411.7FASLG, ISG20, TNFSF10
21doxorubicin44 50 1111.7FAS, FASLG, IL13, TNFSF10, TERC
22genistein44 28 61 2 24 1114.7TNFSF10, GFAP, FAS, FASLG, FPR1
235fluorouracil449.6FAS, TERC, TNFSF10, BNIP3, FASLG
24cyclosporin a44 28 6111.6IL13, FPR1, FASLG, FAS, TNFSF10
25ceramide449.6TNFSF10, BNIP3, FASLG, FAS
26depsipeptide449.6CXADR, FASLG, TNFSF10, FAS
27paclitaxel44 50 1111.6BNIP3, FASLG, FAS, TNFSF10, GFAP
28wortmannin449.6NUDT6, TNFSF10, FAS, FASLG, IL13, FPR1
29pd 98,059449.6IL13, FASLG, FAS, TNFSF10, GFAP, NUDT6
305-aza-2deoxycytidine449.5MAGED4B, FASLG, FAS, TNFSF10, BNIP3
31fludarabine44 50 1111.5TNFSF10, FAS, FASLG
32sb 20358044 6110.5BNIP3, FPR1, IL13, FASLG, FAS, TNFSF10
33lactate449.3NUDT6, FASLG, IL13, GFAP, BNIP3, FAS
34butyrate449.2TERC, FAS, TNFSF10, FASLG, CXADR, GFAP
35estrogen449.0BNIP3, TNFSF10, GFAP, TERC, ISG20, IL13
36phosphatidylinositol449.0TNFRSF6B, TNFSF10, FAS, FASLG, BNIP3, IL13
37oligonucleotide449.0FASLG, FPR1, DCT, ISG20, TERC, FAS
38dexamethasone44 50 28 1112.0FPR1, IL13, CXADR, FASLG, FAS, TNFSF10
39aspartate449.0GFAP, FAS, FASLG, CXADR, IL13
40heparin44 28 24 1111.9IL13, CXADR, FASLG, FAS, FPR1
41cisplatin44 50 61 1111.7FASLG, GFAP, TERC, CXADR, FAS, DCT
42glutamate448.7TNFSF10, IL13, NUDT6, GFAP, FASLG, FABP7
43vegf448.7FASLG, BNIP3, FPR1, IL13, IL13RA1, FAS
44adenylate448.7CXADR, FASLG, DCT, GFAP, IL13
45thymidine44 249.7TERC, NUDT6, GFAP, FAS, FASLG, CXADR
46serine448.6CXADR, NUDT6, GFAP, TNFSF10, FAS, FASLG
47cysteine448.5IL13, CXADR, FASLG, FAS, DCT, GFAP
48nitric oxide44 24 1110.3FASLG, CXADR, IL13RA1, IL13, FPR1, BNIP3
49retinoic acid44 248.9CXADR, FPR1, IL13, FABP7, FASLG, FAS
50tyrosine447.5IL13RA1, IL13, FPR1, DCT, FASLG, ISG20

GO Terms for genes affiliated with Malignant Glioma

About this section

Cellular components related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.8IL13, FASLG, FAS
2extracellular spaceGO:0056158.4IL13, IL13RA2, CXADR, FASLG, TNFRSF6B, TNFSF10

Biological processes related to Malignant Glioma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FASLG, FAS
2necroptotic signaling pathwayGO:09752710.2FASLG, FAS
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.1FASLG, FAS, TNFSF10
4positive regulation of immunoglobulin productionGO:00263910.0IL13, IL13RA1
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.9FASLG, FAS, TNFSF10
6positive regulation of release of cytochrome c from mitochondriaGO:0902009.9TNFSF10, BNIP3
7cellular response to mechanical stimulusGO:0712609.8BNIP3, FAS, IL13
8apoptotic signaling pathwayGO:0971909.7FASLG, FAS, TNFSF10
9positive regulation of apoptotic processGO:0430659.4BNIP3, TNFSF10, FAS, FASLG
10apoptotic processGO:0069159.4BNIP3, TNFSF10, TNFRSF6B, FAS, FASLG
11signal transductionGO:0071659.3TNFSF10, FAS, FASLG, IL13RA2, IL13, FPR1
12defense response to virusGO:0516078.8BNIP3, ISG20, CXADR

Molecular functions related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00516410.0FASLG, TNFSF10
2cytokine activityGO:0051259.5IL13, FASLG, TNFSF10

Products for genes affiliated with Malignant Glioma

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Malignant Glioma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet