MCID: MLG068
MIFTS: 66

Malignant Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Malignant Glioma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises... more...

MalaCards: Malignant Glioma, also known as glioma, is related to astrocytoma and herpes simplex. An important gene associated with Malignant Glioma is LGI1 (leucine-rich, glioma inactivated 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and endothelial, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology:8 A cell type cancer that has material basis in glial cells and is located in brain or located in spine.

Description from OMIM:46 137800

Aliases & Classifications for Malignant Glioma

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 46OMIM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

malignant glioma 8 10 44 30 60
glioma 8 42 44 60
glioma, malignant, no icd-o subtype 8
malignant glioma - category 8
malignant neuroglial tumor 8
glioma, malignant 8
neuroglial tumor 8
glial cell tumor 8
glioma, nos 8
glioma nos 8
gliomas 8


Related Diseases for Malignant Glioma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Glioma family:

Benign Glioma

Diseases related to Malignant Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.6TNFSF10, TNFRSF6B, MAGED4B, IL13, IL13RA2, GFAP
2herpes simplex30.5TNFRSF6B, TNFSF10
3brain cancer30.4TNFSF10, LGI1, MSI1, TERC, GFAP, IL13RA2
4glioblastoma multiforme30.4TNFSF10, IL13, IL13RA1, IL13RA2, GFAP, LGI1
5medulloblastoma30.2GFAP, IL13RA2, TNFSF10
6adenocarcinoma30.0BNIP3, TNFSF10, TNFRSF6B, FAS, IL13RA2, ACSL5
7breast cancer30.0BNIP3, TNFSF10, FABP7, FAS, PPAT, TERC
8adenoma30.0TERC, ACSL5
9lung cancer30.0BNIP3, TNFSF10, FAS, PPAT, TERC
10melanoma29.9TNFSF10, FAS, PPAT, MAGED4B, TERC
11multiple sclerosis29.6TNFSF10, IL13, GFAP
12subependymal giant cell astrocytoma29.6GFAP
13neuroblastoma10.7
14optic nerve glioma10.7
15brain glioma10.7
16chordoid glioma10.6
17neurofibromatosis10.5
18third ventricle chordoid glioma10.5
19spinal cord glioma10.5
20mixed glioma10.4
21oligodendroglioma10.4
22differentiating neuroblastoma10.3
23glioma somatic10.3
24brain edema10.2
25cerebritis10.2
26childhood brain stem glioma10.2
27leukemia10.2
28subependymal glioma10.2
29thyroiditis10.2
30retinoblastoma10.2
31cholera10.1
32arteriovenous malformation10.1
33neuronitis10.1
34lymphopenia10.1
35malignant ependymoma10.1
36meningioma10.1
37meningitis10.1
38adult brainstem mixed glioma10.1
39gliosarcoma10.1
40optic pathway glioma10.1
41central nervous system lymphoma10.1
42vaccinia10.1
43arachnoiditis10.1
44childhood optic nerve glioma10.1
45acoustic neuroma10.1
46hepatocellular carcinoma10.1
47neuroma10.1
48pertussis10.1
49rhabdomyosarcoma10.1
50syringomyelia10.0

Graphical network of the top 20 diseases related to Malignant Glioma:



Diseases related to malignant glioma

Clinical Features for Malignant Glioma

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Sources:
46OMIM
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Clinical features from OMIM:

137800

Drugs & Therapeutics for Malignant Glioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Glioma

Drug clinical trials:

Search ClinicalTrials for Malignant Glioma

Search NIH Clinical Center for Malignant Glioma

Search CenterWatch for Malignant Glioma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malignant Glioma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malignant Glioma:
ALD-451, bone marrow-derived cells for malignant glioma
Embryonic/Adult Cultured Cells Related to Malignant Glioma:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905

Genetic Tests for Malignant Glioma

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Anatomical Context for Malignant Glioma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Malignant Glioma:

32
Brain, Endothelial, Bone, T cells, Monocytes, Spinal cord, Bone marrow, Nk cells, Dentritic cells, Myeloid, Testes, Prostate, Breast, Lung, Liver, Colon, Skeletal muscle, Cortex

FMA organs/tissues related to Malignant Glioma:

14
Brain or

Animal Models for Malignant Glioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.2MSI1, BNIP3, SOX11, TNFSF10, FABP7, FAS
2MP:001076812.1EFEMP1, PPME1, FAS, TNFSF10, SOX11, IL13
3MP:000538711.8SOX11, TNFSF10, FAS, EFEMP1, IL13, IL13RA1
4MP:000539711.6BNIP3, SOX11, TNFSF10, FAS, EFEMP1, IL13
5MP:000538111.2SOX11, FAS, EFEMP1, IL13, FPR1, GFAP
6MP:000118611.0LGI1, TERC, EFEMP1, FAS
7MP:000538810.9SOX11, FAS, PPME1, IL13, IL13RA1, TERC

Publications for Malignant Glioma

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50PubMed
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Articles related to Malignant Glioma:

(show top 50)    (show all 1111)
idTitleAuthorsYear
1
Radiation-induced upregulation of telomerase activity escapes PI3-kinase inhibition in two malignant glioma cell lines. (23727752)
2013
2
Phase I study of GRN1005 in recurrent malignant glioma. (23349317)
2013
3
Oncolytic virotherapy for malignant glioma: translating laboratory insights into clinical practice. (23443138)
2013
4
Identification of novel genetic alterations in samples of malignant glioma patients. (24358143)
2013
5
Response assessment of bevacizumab in patients with recurrent malignant glioma using [18F]Fluoroethyl-L-tyrosine PET in comparison to MRI. (23053325)
2013
6
Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun NH2-terminal kinase pathway. (23022184)
2012
7
Future approaches for the therapy of malignant glioma: targeting genes mediating invasion. (22515436)
2012
8
Trace elements, heavy metals and other biochemical parameters in malignant glioma patients. (21545211)
2011
9
Cotransfected sodium iodide symporter and human tyroperoxidase genes following human telomerase reverse transcriptase promoter for targeted radioiodine therapy of malignant glioma cells. (21797672)
2011
10
Immature and absolute platelet count changes and thrombocytopenia in malignant glioma. (21158849)
2011
11
FET-PET for malignant glioma treatment planning. (21458093)
2011
12
Hoechst 33342 induces radiosensitization in malignant glioma cells via increase in mitochondrial reactive oxygen species. (20540663)
2010
13
Plant thymidine kinase 1: a novel efficient suicide gene for malignant glioma therapy. (20154339)
2010
14
Malignant transformation of an optic pathway glioma without prior radiation therapy. (20433265)
2010
15
Anti-invasive and antiangiogenic effects of MMI-166 on malignant glioma cells. (20587068)
2010
16
Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cells. (19913408)
2010
17
Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2. (19398149)
2009
18
EGFRvIII-targeted vaccination therapy of malignant glioma. (19744042)
2009
19
Head's up on the treatment of malignant glioma patients. (19726382)
2009
20
Gene delivery by embryonic stem cells for malignant glioma therapy: hype or hope? (18719364)
2008
21
Inhibition of N-(4-hydroxyphenyl)retinamide-induced autophagy at a lower dose enhances cell death in malignant glioma cells. (18174255)
2008
22
Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro. (18940013)
2008
23
Mechanisms of chemoresistance to alkylating agents in malignant glioma. (18483356)
2008
24
Molecular strategies for the treatment of malignant glioma--genes, viruses, and vaccines. (18259789)
2008
25
Cerebral metabolism during air transport of patients after surgery for malignant glioma. (18619131)
2008
26
Novel anti-angiogenic therapies for malignant gliomas. (19007739)
2008
27
Effects of PTEN gene on human malignant glioma growth in vitro]. (17760247)
2007
28
Type I collagen gene suppresses tumor growth and invasion of malignant human glioma cells. (17578585)
2007
29
Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts. (17310280)
2007
30
Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas. (17332917)
2007
31
The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. (16510597)
2006
32
Identification of histological markers for malignant glioma by genome-wide expression analysis: dynein, alpha-PIX and sorcin. (16320026)
2006
33
O6-methylguanine-DNA methyltransferase expression strongly correlates with outcome in childhood malignant gliomas: results from the CCG-945 Cohort. (16849758)
2006
34
Malignant glioma: neuropathology and neurobiology. (16944363)
2006
35
Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma. (15558802)
2005
36
Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. (12651152)
2003
37
Oncolytic activity of the E1B-55 kDa-deleted adenovirus ONYX-015 is independent of cellular p53 status in human malignant glioma xenografts. (11830531)
2002
38
Astrocyte-specific expression of activated p21-ras results in malignant astrocytoma formation in a transgenic mouse model of human gliomas. (11325859)
2001
39
Homozygous deletion of the p16/MTS-1/CDKN2 gene in malignant gliomas is infrequent among Japanese patients. (10536183)
1999
40
Anomalous p27kip1 expression in a subset of malignant gliomas. (10532419)
1999
41
Malignant human gliomas express an amiloride-sensitive Na+ conductance. (10362604)
1999
42
FADD gene therapy for malignant gliomas in vitro and in vivo. (9694158)
1998
43
Effects of insulin on protein phosphorylation and protein kinase C activity in human malignant gliomas. (9536517)
1998
44
Generation of fiber-mutant recombinant adenoviruses for gene therapy of malignant glioma. (9853517)
1998
45
Application of antisense ribonucleic acid complementary to O6-methylguanine-deoxyribonucleic acid methyltransferase messenger ribonucleic acid for therapy of malignant gliomas. (9257312)
1997
46
Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression. (8965097)
1996
47
Expression of osteopontin in human glioma. Its correlation with the malignancy. (7837791)
1995
48
p53 mutations and microsatellite analysis of loss of heterozygosity in malignant gliomas. (8019958)
1994
49
Differential effects of tumor necrosis factor-alpha on proliferation, cell surface antigen expression, and cytokine interactions in malignant gliomas. (8093640)
1993
50
Patterns of epithelial metaplasia in malignant gliomas. I. Papillary formations mimicking medulloepithelioma. (2828555)
1988

Genetic Variations for Malignant Glioma

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Expression for genes affiliated with Malignant Glioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Glioma

Search GEO for disease gene expression data for Malignant Glioma.

Pathways for genes affiliated with Malignant Glioma

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Malignant Glioma

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Malignant Glioma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1vegf4411.7GFAP, FPR1, IL13RA1, IL13, FAS, TNFSF10
2retinoic acid44 2412.7TNFSF10, FABP7, FAS, IL13, FPR1, GFAP
3phosphatidylinositol4411.6BNIP3, TNFSF10, TNFRSF6B, FAS, IL13, FPR1
4nitric oxide44 11 2413.6BNIP3, TNFSF10, FAS, IL13, IL13RA1, FPR1
5sb 20358044 5912.5BNIP3, TNFSF10, FAS, IL13, FPR1
6glutamine4411.5TNFSF10, FAS, PPAT, IL13, GFAP
7fatty acid4411.5BNIP3, TNFSF10, FABP7, FAS, ACSL5
8cisplatin44 49 59 1114.4TNFSF10, FAS, PPAT, GFAP, TERC
9thymidine44 2412.4TERC, GFAP, IL13RA1, IL13, FAS
10ionomycin4411.3TNFSF10, FAS, IL13, FPR1
115-aza-2deoxycytidine4411.3MAGED4B, FAS, TNFSF10, BNIP3
125fluorouracil4411.3BNIP3, TNFSF10, FAS, TERC
13indomethacin44 59 28 1114.2FPR1, IL13, FAS, TNFSF10
14dutp4411.2TNFSF10, FAS, GFAP
15butyrate4411.2TERC, GFAP, FAS, TNFSF10
16glutamate4411.2FABP7, PPAT, GFAP
17paclitaxel44 49 1113.2BNIP3, TNFSF10, FAS, GFAP
18ifn-alpha4411.2IL13, FAS, TNFSF10
19doxycycline44 1112.2GFAP, IL13, TNFSF10
20rottlerin4411.1IL13, FAS, TNFSF10
21cyclosporin h44 2812.1FPR1, IL13
22tetracycline44 1112.1TNFSF10, FAS, GFAP
23pd 98,0594411.0GFAP, IL13, FAS, TNFSF10
24adpribose4411.0TERC, FAS, TNFSF10
25propentofylline4411.0FAS, GFAP
26sp 60012544 5912.0IL13, FAS, TNFSF10
27alpha-galactosylceramide4411.0IL13, TNFSF10
28wortmannin4411.0TNFSF10, FAS, IL13, FPR1
29cytarabine44 49 1113.0TNFSF10, FAS, GFAP
30doxorubicin44 49 1112.9TERC, IL13, FAS, TNFSF10
31adriamycin4410.8TERC, FAS, TNFSF10
32dexamethasone44 49 28 1113.8TNFSF10, FAS, IL13, FPR1, GFAP

GO Terms for genes affiliated with Malignant Glioma

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16Gene Ontology
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Cellular components related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.2LGI1, IL13RA2, IL13, EFEMP1, TNFRSF6B, TNFSF10

Biological processes related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.2FAS, IL13, IL13RA2, FPR1, LRRN2, TNFSF10
2cellular response to mechanical stimulusGO:07126010.7IL13, FAS, BNIP3
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.4FAS, TNFSF10

Molecular functions related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:00489610.7IL13RA2, IL13RA1
2receptor activityGO:00487210.7LRRN2, FPR1, FAS, TNFRSF6B

Products for genes affiliated with Malignant Glioma

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Sources for Malignant Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet