MCID: MLG068
MIFTS: 58

Malignant Glioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Malignant Glioma

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Wikipedia:63 A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises... more...

MalaCards based summary: Malignant Glioma, also known as glioma, is related to herpes simplex and brain cancer. An important gene associated with Malignant Glioma is FABP7 (fatty acid binding protein 7, brain), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Apoptosis. The compounds cyclosporin h and concanamycin a have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and endothelial, and related mouse phenotypes are vision/eye and integument.

Disease Ontology:9 A cell type cancer that has material basis in glial cells and is located in brain or located in spine.

Aliases & Classifications for Malignant Glioma

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Malignant Glioma, Aliases & Descriptions:

Name: Malignant Glioma 30 9 11 43 60
Glioma 9 41 43 60
Glioma, Malignant, No Icd-O Subtype 9
Malignant Glioma - Category 9
Malignant Neuroglial Tumor 9
Glioma, Malignant 9
 
Glial Cell Tumor 9
Neuroglial Tumor 9
Glial Tumor 41
Glioma, Nos 9
Glioma Nos 9
Gliomas 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:3070
ICD9CM27 191
MeSH33 D005910
NCIt38 C3059

Related Diseases for Malignant Glioma

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Diseases in the Benign Glioma family:

malignant glioma

Diseases related to Malignant Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 311)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex30.8TNFSF10, ISG20, TNFRSF6B
2brain cancer30.6GFAP, IL13
3medulloblastoma30.5NUDT6, TNFSF10, IL13RA2, GFAP
4subependymal giant cell astrocytoma30.4GFAP
5retinoblastoma30.1TERC, CXADR, DCT, GFAP
6gastric adenocarcinoma30.0FAS, FASLG, TERC
7astrocytoma29.9IL13RA2, IL13, MAGED4B, TNFSF10, CXADR, FASLG
8lung cancer29.9TERC, TNFSF10, CXADR, FAS
9stomach cancer29.9TNFRSF6B, FASLG, FAS, TERC
10hepatocellular carcinoma29.8TERC, TNFSF10, TNFRSF6B, FAS, CXADR, FASLG
11pancreatic cancer29.8BNIP3, TNFRSF6B, FASLG, TERC, TNFSF10
12glioblastoma multiforme29.7CXADR, FASLG, IL13RA2, IL13, DCT, GFAP
13leukemia29.5TNFSF10, NUDT6, ISG20, FAS, FPR1, FASLG
14breast cancer29.3BNIP3, ISG20, TNFSF10, CXADR, NUDT6, FAS
15adenocarcinoma29.2TNFRSF6B, FASLG, TERC, BNIP3, NUDT6, TNFSF10
16prostate cancer28.9TERC, BNIP3, NUDT6, IL13RA2, FAS, TNFSF10
17glioblastoma28.9FPR1, TERC, MAGED4B, IL13, IL13RA1, TNFRSF6B
18melanoma28.9CXADR, FASLG, TERC, NUDT6, TNFSF10, MAGED4B
19brain glioma10.9
20neuroblastoma10.8
21optic nerve glioma10.8
22optic pathway glioma10.7
23chordoid glioma10.7
24brain stem glioma10.7
25endotheliitis10.7
26neurofibromatosis10.6
27angiocentric glioma10.6
28neurofibromatosis, type 110.5
29spinal cord glioma10.5
30mixed glioma10.5
31oligodendroglioma10.5
32hypoxia10.4
33glioma susceptibility 110.4
34grade iii astrocytoma10.3TNFSF10, GFAP, IL13RA1
35cerebritis10.3
36silicosis10.3FASLG, FAS
37brain edema10.3
38third ventricle chordoid glioma10.3
39thyroiditis10.3
40encephalocele10.3
41vogt-koyanagi-harada disease10.3FAS, FASLG
42lymphomatoid papulosis10.3FASLG, FAS
43allergic asthma10.3IL13RA1, IL13RA2, IL13
44cowpox10.2TNFSF10, FAS
45differentiating neuroblastoma10.2
46childhood brain stem glioma10.2
47subependymal glioma10.2
48hypersensitivity syndrome, carbamazepine-induced10.2FAS, FASLG
49autoimmune lymphoproliferative syndrome10.2FAS, FASLG
50pulmonary fibrosis, idiopathic10.2FASLG, TERC, IL13

Graphical network of the top 20 diseases related to Malignant Glioma:



Diseases related to malignant glioma

Symptoms for Malignant Glioma

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Drugs & Therapeutics for Malignant Glioma

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Drug clinical trials:

Search ClinicalTrials for Malignant Glioma

Search NIH Clinical Center for Malignant Glioma

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Malignant Glioma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malignant Glioma:
ALD-451, bone marrow-derived cells for malignant glioma
Embryonic/Adult Cultured Cells Related to Malignant Glioma:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905

Genetic Tests for Malignant Glioma

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Anatomical Context for Malignant Glioma

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MalaCards organs/tissues related to Malignant Glioma:

31
Brain, Endothelial, Bone, T cells, Monocytes, Bone marrow, Prostate, Cortex, Skeletal muscle, Colon, Liver, Lung, Breast, Testes, Dentritic cells, Nk cells, Neutrophil

FMA organs/tissues related to Malignant Glioma:

14
Brain or

Animal Models for Malignant Glioma or affiliated genes

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Publications for Malignant Glioma

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Articles related to Malignant Glioma:

(show top 50)    (show all 1050)
idTitleAuthorsYear
1
Tomato thymidine kinase-based suicide gene therapy for malignant glioma-an alternative for Herpes Simplex virus-1 thymidine kinase. (25613481)
2015
2
Interstitial chemotherapy for malignant glioma: Future prospects in the era of multimodal therapy. (25722936)
2015
3
Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis. (24220141)
2013
4
Prognostic value of isocitrate dehydrogenase 1, O6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients. (24160898)
2013
5
Re-irradiation in recurrent malignant glioma: prognostic value of [18F]FET-PET. (23054562)
2012
6
Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor I+2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele. (22424217)
2012
7
Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma. (22844129)
2012
8
A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma. (22832897)
2012
9
Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. (21173573)
2011
10
Cell surface receptors in malignant glioma. (21522029)
2011
11
O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. (21365007)
2011
12
Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. Clinical article. (20964595)
2011
13
Papillary endothelial hyperplasia presenting as recurrent malignant glioma. (20740304)
2011
14
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells. (20946108)
2011
15
Human malignant glioma cells expressing functional formylpeptide receptor recruit endothelial progenitor cells for neovascularization. (20933627)
2010
16
MGMT promoter methylation in malignant gliomas: ready for personalized medicine? (19997073)
2010
17
Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma. (20702765)
2010
18
Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. (20479404)
2010
19
Hoechst 33342 induces radiosensitization in malignant glioma cells via increase in mitochondrial reactive oxygen species. (20540663)
2010
20
High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (20555079)
2010
21
Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2. (19398149)
2009
22
Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas. (19686285)
2009
23
Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo. (19277041)
2009
24
Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation. (19199463)
2009
25
yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients. (19900287)
2009
26
Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma. (17924059)
2008
27
Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma. (18948169)
2008
28
Molecular targeted therapies and chemotherapy in malignant gliomas. (17906459)
2007
29
The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications. (17373877)
2007
30
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. (16818640)
2006
31
Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy. (16700620)
2006
32
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells. (16516855)
2006
33
Malignant glioma: the involvement of loss of allelic heterozygosity and PTEN mutations in a group of Malay patients. (16124450)
2005
34
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. (15205343)
2004
35
Expression of mutant non-cleavable Fas ligand on retrovirus packaging cells causes apoptosis of immunocompetent cells and improves prodrug activation gene therapy in a malignant glioma model. (12888123)
2003
36
Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. (12651152)
2003
37
PTEN mutations in malignant gliomas and their relation with meningeal gliomatosis. (11678426)
2001
38
Monitoring activation of ribonuclease L by 2',5'-oligoadenylates using purified recombinant enzyme and intact malignant glioma cells. (11586885)
2001
39
A novel role for the urokinase-type plasminogen activator receptor in apoptosis of malignant gliomas. (10853019)
2000
40
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells. (10569804)
1999
41
Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of experimental intracranial human malignant glioma. (10533721)
1999
42
Soluble CD95 (Fas/APO-1) in malignant glioma: (no) implications for CD95-based immunotherapy? (10066095)
1998
43
Interferon-alpha enhances CD95L-induced apoptosis of human malignant glioma cells. (9670853)
1998
44
Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. (9484714)
1998
45
Biological profiles of malignant gliomas]. (7675550)
1995
46
Modulation of O6-methylguanine-DNA methyltransferase-mediated nimustine resistance in recurrent malignant gliomas by streptozotocin--a preliminary report. (7763050)
1995
47
Basic research for interferon gene therapy against malignant glioma]. (1598130)
1992
48
Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. (2352010)
1990
49
Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro. (2224848)
1990
50
Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas. (2814622)
1989

Variations for Malignant Glioma

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Cosmic variations for Malignant Glioma:

7 (show all 212)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
111084TP53central nervous system,brain,glioma,NS3
244169TP53central nervous system,brain,glioma,NS3
344226TP53central nervous system,brain,glioma,NS3
443945TP53central nervous system,brain,glioma,NS3
510834TP53central nervous system,brain,glioma,NS3
643833TP53central nervous system,brain,glioma,NS3
711498TP53central nervous system,brain,glioma,NS3
810912TP53central nervous system,brain,glioma,NS3
910867TP53central nervous system,brain,glioma,NS3
1011066TP53central nervous system,brain,glioma,NS3
1144327TP53central nervous system,brain,glioma,NS3
1210645TP53central nervous system,brain,glioma,NS3
1344204TP53central nervous system,brain,glioma,NS3
1410731TP53central nervous system,brain,glioma,NS3
1510739TP53central nervous system,brain,glioma,NS3
1610808TP53central nervous system,brain,glioma,NS3
1744092TP53central nervous system,brain,glioma,NS3
1810758TP53central nervous system,brain,glioma,NS3
1911305TP53central nervous system,brain,glioma,NS3
2043606TP53central nervous system,brain,glioma,NS3
2110690TP53central nervous system,brain,glioma,NS3
2210863TP53central nervous system,brain,glioma,NS3
2310718TP53central nervous system,brain,glioma,NS3
2410742TP53central nervous system,brain,glioma,NS3
2543900TP53central nervous system,brain,glioma,NS3
2610790TP53central nervous system,brain,glioma,NS3
2744221TP53central nervous system,brain,glioma,NS3
2843708TP53central nervous system,brain,glioma,NS3
2943651TP53central nervous system,brain,glioma,NS3
3011059TP53central nervous system,brain,glioma,NS3
3110701TP53central nervous system,brain,glioma,NS3
3245368TP53central nervous system,brain,glioma,NS3
3344877TP53central nervous system,brain,glioma,NS3
3444613TP53central nervous system,brain,glioma,NS3
3511210TP53central nervous system,brain,glioma,NS3
3644271TP53central nervous system,brain,glioma,NS3
3745045TP53central nervous system,brain,glioma,NS3
3810667TP53central nervous system,brain,glioma,NS3
3910659TP53central nervous system,brain,glioma,NS3
4010771TP53central nervous system,brain,glioma,NS3
4143970TP53central nervous system,brain,glioma,NS3
426932TP53central nervous system,brain,glioma,NS3
4343923TP53central nervous system,brain,glioma,NS3
4410662TP53central nervous system,brain,glioma,NS3
4543739TP53central nervous system,brain,glioma,NS3
4610889TP53central nervous system,brain,glioma,NS3
4744525TP53central nervous system,brain,glioma,NS3
4810660TP53central nervous system,brain,glioma,NS3
4944571TP53central nervous system,brain,glioma,NS3
5011250TP53central nervous system,brain,glioma,NS3
5111218TP53central nervous system,brain,glioma,NS3
5210704TP53central nervous system,brain,glioma,NS3
5310988TP53central nervous system,brain,glioma,NS3
5445796TP53central nervous system,brain,glioma,NS3
5544637TP53central nervous system,brain,glioma,NS3
5610779TP53central nervous system,brain,glioma,NS3
5711071TP53central nervous system,brain,glioma,NS3
5844057TP53central nervous system,brain,glioma,NS3
5911089TP53central nervous system,brain,glioma,NS3
6048817TP53central nervous system,brain,glioma,NS3
6110794TP53central nervous system,brain,glioma,NS3
6210935TP53central nervous system,brain,glioma,NS3
6343555TP53central nervous system,brain,glioma,NS3
6410687TP53central nervous system,brain,glioma,NS3
6544633TP53central nervous system,brain,glioma,NS3
6611087TP53central nervous system,brain,glioma,NS3
6710728TP53central nervous system,brain,glioma,NS3
6810648TP53central nervous system,brain,glioma,NS3
6910656TP53central nervous system,brain,glioma,NS3
7043767TP53central nervous system,brain,glioma,NS3
7143565TP53central nervous system,brain,glioma,NS3
7211392TP53central nervous system,brain,glioma,NS3
7311462TP53central nervous system,brain,glioma,NS3
743967199PTENcentral nervous system,brain,glioma,NS3
755043PTENcentral nervous system,brain,glioma,NS3
765243PTENcentral nervous system,brain,glioma,NS3
775137PTENcentral nervous system,brain,glioma,NS3
785113PTENcentral nervous system,brain,glioma,NS3
795253PTENcentral nervous system,brain,glioma,NS3
805089PTENcentral nervous system,brain,glioma,NS3
815109PTENcentral nervous system,brain,glioma,NS3
825127PTENcentral nervous system,brain,glioma,NS3
835212PTENcentral nervous system,brain,glioma,NS3
845036PTENcentral nervous system,brain,glioma,NS3
855185PTENcentral nervous system,brain,glioma,NS3
865269PTENcentral nervous system,brain,glioma,NS3
875051PTENcentral nervous system,brain,glioma,NS3
883967200PTENcentral nervous system,brain,glioma,NS3
89163810PTENcentral nervous system,brain,glioma,NS3
905186PTENcentral nervous system,brain,glioma,NS3
915275PTENcentral nervous system,brain,glioma,NS3
925268PTENcentral nervous system,brain,glioma,NS3
93775PIK3CAcentral nervous system,brain,glioma,NS3
9413570PIK3CAcentral nervous system,brain,glioma,NS3
956147PIK3CAcentral nervous system,brain,glioma,NS3
9612458PIK3CAcentral nervous system,brain,glioma,NS3
97776PIK3CAcentral nervous system,brain,glioma,NS3
981041479PIK3CAcentral nervous system,brain,glioma,NS3
99767PIK3CAcentral nervous system,brain,glioma,NS3
10012459PIK3CAcentral nervous system,brain,glioma,NS3
101760PIK3CAcentral nervous system,brain,glioma,NS3
10212463PIK3CAcentral nervous system,brain,glioma,NS3
103764PIK3CAcentral nervous system,brain,glioma,NS3
104249139PIK3CAcentral nervous system,brain,glioma,NS3
10512584PIK3CAcentral nervous system,brain,glioma,NS3
106751PIK3CAcentral nervous system,brain,glioma,NS3
10712591PIK3CAcentral nervous system,brain,glioma,NS3
108763PIK3CAcentral nervous system,brain,glioma,NS3
10941293IDH1central nervous system,brain,glioma,NS3
11028750IDH1central nervous system,brain,glioma,NS3
11151384IDH1central nervous system,brain,glioma,NS3
11228746IDH1central nervous system,brain,glioma,NS3
11341292IDH1central nervous system,brain,glioma,NS3
11428747IDH1central nervous system,brain,glioma,NS3
11541294IDH1central nervous system,brain,glioma,NS3
11628749IDH1central nervous system,brain,glioma,NS3
11728748IDH1central nervous system,brain,glioma,NS3
11841291IDH1central nervous system,brain,glioma,NS3
11934090IDH2central nervous system,brain,glioma,NS3
12086077IDH2central nervous system,brain,glioma,NS3
121144496IDH2central nervous system,brain,glioma,NS3
12234039IDH2central nervous system,brain,glioma,NS3
12341295IDH2central nervous system,brain,glioma,NS3
12433733IDH2central nervous system,brain,glioma,NS3
12533732IDH2central nervous system,brain,glioma,NS3
12633731IDH2central nervous system,brain,glioma,NS3
12721687EGFRcentral nervous system,brain,glioma,NS3
12821690EGFRcentral nervous system,brain,glioma,NS3
1291451549EGFRcentral nervous system,brain,glioma,NS3
13013979EGFRcentral nervous system,brain,glioma,NS3
13135752EGFRcentral nervous system,brain,glioma,NS3
13221683EGFRcentral nervous system,brain,glioma,NS3
13313029PTPN11central nervous system,brain,glioma,NS3
13424612PTPN11central nervous system,brain,glioma,NS3
13513035PTPN11central nervous system,brain,glioma,NS3
13613993PTPN11central nervous system,brain,glioma,NS3
1371681078CICcentral nervous system,brain,glioma,NS3
138303956CICcentral nervous system,brain,glioma,NS3
1391737905CICcentral nervous system,brain,glioma,NS3
1401684815PDGFRAcentral nervous system,brain,glioma,NS3
14113348PDGFRAcentral nervous system,brain,glioma,NS3
14243059PDGFRAcentral nervous system,brain,glioma,NS3
1431266238SMARCA4central nervous system,brain,glioma,NS3
144303247SMARCA4central nervous system,brain,glioma,NS3
14513366STYK1central nervous system,brain,glioma,NS3
1461716195STYK1central nervous system,brain,glioma,NS3
147467BRAFcentral nervous system,brain,glioma,NS3
148476BRAFcentral nervous system,brain,glioma,NS3
14913324MTORcentral nervous system,brain,glioma,NS3
1501662881MTORcentral nervous system,brain,glioma,NS3
1511669313TANC1central nervous system,brain,glioma,NS3
1521669315TANC1central nervous system,brain,glioma,NS3
15313373TRIM33central nervous system,brain,glioma,NS3
15413372TRIM33central nervous system,brain,glioma,NS3
1551681227IL4I1central nervous system,brain,glioma,NS3
1561716185LETM1central nervous system,brain,glioma,NS3
157132886KRAScentral nervous system,brain,glioma,NS3
15813327GUCY2Fcentral nervous system,brain,glioma,NS3
15913331INSRRcentral nervous system,brain,glioma,NS3
16013332IRAK1central nervous system,brain,glioma,NS3
1611212907KSR1central nervous system,brain,glioma,NS3
1621676183KAT5central nervous system,brain,glioma,NS3
1631679282KARScentral nervous system,brain,glioma,NS3
164244789GRB7central nervous system,brain,glioma,NS3
165679210EPHA8central nervous system,brain,glioma,NS3
1661670399CBLBcentral nervous system,brain,glioma,NS3
1671200426CDH16central nervous system,brain,glioma,NS3
1681246131BLKcentral nervous system,brain,glioma,NS3
169917933ANKRD30Acentral nervous system,brain,glioma,NS3
17039766ACLYcentral nervous system,brain,glioma,NS3
1711348446ANK3central nervous system,brain,glioma,NS3
17213272CDKN2Acentral nervous system,brain,glioma,NS3
173417011CREBBPcentral nervous system,brain,glioma,NS3
17413320EPHB6central nervous system,brain,glioma,NS3
175684ERBB2central nervous system,brain,glioma,NS3
17639419FGFR3central nervous system,brain,glioma,NS3
17726928LIN28Acentral nervous system,brain,glioma,NS3
17813318EPHA6central nervous system,brain,glioma,NS3
1791675009EHMT1central nervous system,brain,glioma,NS3
1801681167ELSPBP1central nervous system,brain,glioma,NS3
18113323FLT1central nervous system,brain,glioma,NS3
182580NRAScentral nervous system,brain,glioma,NS3
1831045668SMARCC1central nervous system,brain,glioma,NS3
184989762SOCS6central nervous system,brain,glioma,NS3
1851374208SMAD3central nervous system,brain,glioma,NS3
18613363SIK1central nervous system,brain,glioma,NS3
1871668574SLC35F3central nervous system,brain,glioma,NS3
1881267026SUMF2central nervous system,brain,glioma,NS3
1891671363TMEM154central nervous system,brain,glioma,NS3
19013374TYRO3central nervous system,brain,glioma,NS3
1911371355TSHRcentral nervous system,brain,glioma,NS3
1921080380TINAGcentral nervous system,brain,glioma,NS3
19354432TAF4Bcentral nervous system,brain,glioma,NS3
19421289TEX14central nervous system,brain,glioma,NS3
1951716243TFDP1central nervous system,brain,glioma,NS3
1961265475SH2D3Ccentral nervous system,brain,glioma,NS3
197485575PMS2P11central nervous system,brain,glioma,NS3
1981470691POTEMcentral nervous system,brain,glioma,NS3
199475213ZNF845central nervous system,brain,glioma,NS3
200443415ZAP70central nervous system,brain,glioma,NS3
201420536MUC7central nervous system,brain,glioma,NS3
2021680324NOL4central nervous system,brain,glioma,NS3
20313349PDK2central nervous system,brain,glioma,NS3
2041088134PRPS1L1central nervous system,brain,glioma,NS3
20539437RAC2central nervous system,brain,glioma,NS3
2061111027ROR2central nervous system,brain,glioma,NS3
20795220RUNX1T1central nervous system,brain,glioma,NS3
2081668765RAB10central nervous system,brain,glioma,NS3
209551917YY1central nervous system,brain,glioma,NS3
21013355PTK2central nervous system,brain,glioma,NS3
2111673725PTPRN2central nervous system,brain,glioma,NS3
21213341MSH6central nervous system,brain,glioma,NS3

Expression for genes affiliated with Malignant Glioma

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Search GEO for disease gene expression data for Malignant Glioma.

Pathways for genes affiliated with Malignant Glioma

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Pathways related to Malignant Glioma according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0FASLG, FAS
2
Show member pathways
9.8FASLG, FAS, TNFSF10
3
Show member pathways
TRAIL signaling pathway36
9.8FASLG, FAS, TNFSF10
4
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways58
9.8FASLG, FAS, TNFSF10
5
Show member pathways
9.8TNFSF10, FAS, FASLG
6
Show member pathways
FAS pathway and Stress induction of HSP regulation36
Apoptosis and survival FAS signaling cascades58
Caspase cascade in apoptosis36
9.8TNFRSF6B, FAS, FASLG
7
Show member pathways
PLK2 and PLK4 events36
Polo-like kinase signaling events in the cell cycle36
9.7BNIP3, TNFSF10, FASLG
8
Show member pathways
Type III interferon signaling36
9.7IL13, IL13RA1, IL13RA2
9
Show member pathways
9.6FASLG, FAS, TNFRSF6B, TNFSF10
109.6TNFSF10, TNFRSF6B, FAS, FASLG
11
Show member pathways
Apoptosis and survival TNFR1 signaling pathway58
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
9.6TNFSF10, TNFRSF6B, FAS, FASLG
12
Show member pathways
9.6TNFSF10, FAS, FASLG, IL13
13
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.2FASLG, FAS, TNFRSF6B, TNFSF10, BNIP3
14
Show member pathways
9.2NUDT6, TNFSF10, IL13RA2, IL13RA1, IL13
15
Show member pathways
9.2NUDT6, TNFSF10, IL13RA2, IL13RA1, IL13
16
Show member pathways
9.2NUDT6, TNFSF10, IL13RA2, IL13RA1, IL13
17
Show member pathways
9.2FAS, FASLG, CXADR, IL13
18
Show member pathways
8.8TNFSF10, TNFRSF6B, FAS, FASLG, IL13RA2, IL13RA1
19
Show member pathways
8.3NUDT6, GFAP, TNFSF10, TNFRSF6B, SOX11, IL13RA2

Compounds for genes affiliated with Malignant Glioma

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Compounds related to Malignant Glioma according to GeneCards Suite gene sharing:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1cyclosporin h43 2811.3IL13, FPR1
2concanamycin a43 5911.1TNFSF10, FAS, FASLG
33-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4310.0FAS, FASLG, TNFSF10
4dutp4310.0TNFSF10, GFAP, FAS, FASLG
5adpribose4310.0TNFSF10, TERC, FASLG, FAS
6ifn-alpha4310.0FAS, FASLG, IL13, TNFSF10
7tetracycline43 1211.0GFAP, TNFSF10, FAS, FASLG
8rottlerin4310.0FAS, TNFSF10, FASLG, IL13
9adriamycin4310.0FAS, FASLG, TNFSF10, TERC
10suberoylanilide hydroxamic acid4310.0TNFSF10, FAS, FASLG
11sp 60012543 5910.9TNFSF10, FAS, FASLG, IL13
12cytarabine43 49 1211.9GFAP, FAS, FASLG, TNFSF10
13streptozotocin439.9NUDT6, GFAP, TNFSF10
14dmso439.8NUDT6, FPR1, TNFSF10, TERC
15bromodeoxyuridine439.8FASLG, GFAP, NUDT6, IL13
16ionomycin439.8FAS, FPR1, FASLG, TNFSF10, IL13
17doxycycline43 1210.8FASLG, IL13, TNFSF10, GFAP, NUDT6
18indomethacin43 28 59 1212.8FASLG, TNFSF10, IL13, FAS, FPR1
19agar439.8FAS, GFAP, FASLG, NUDT6, TERC
202-methoxyestradiol43 59 2411.7FASLG, ISG20, TNFSF10
21doxorubicin43 49 1211.7FAS, FASLG, IL13, TNFSF10, TERC
22genistein43 28 59 2 24 1214.7TNFSF10, GFAP, FAS, FASLG, FPR1
235fluorouracil439.6FAS, TERC, TNFSF10, BNIP3, FASLG
24cyclosporin a43 28 5911.6IL13, FPR1, FASLG, FAS, TNFSF10
25ceramide439.6TNFSF10, BNIP3, FASLG, FAS
26depsipeptide439.6CXADR, FASLG, TNFSF10, FAS
27paclitaxel43 49 1211.6BNIP3, FASLG, FAS, TNFSF10, GFAP
28wortmannin439.6NUDT6, TNFSF10, FAS, FASLG, IL13, FPR1
29pd 98,059439.6IL13, FASLG, FAS, TNFSF10, GFAP, NUDT6
305-aza-2deoxycytidine439.5MAGED4B, FASLG, FAS, TNFSF10, BNIP3
31fludarabine43 49 1211.5TNFSF10, FAS, FASLG
32sb 20358043 5910.5BNIP3, FPR1, IL13, FASLG, FAS, TNFSF10
33lactate439.3NUDT6, FASLG, IL13, GFAP, BNIP3, FAS
34butyrate439.2TERC, FAS, TNFSF10, FASLG, CXADR, GFAP
35estrogen439.0BNIP3, TNFSF10, GFAP, TERC, ISG20, IL13
36phosphatidylinositol439.0TNFRSF6B, TNFSF10, FAS, FASLG, BNIP3, IL13
37oligonucleotide439.0FASLG, FPR1, DCT, ISG20, TERC, FAS
38dexamethasone43 49 28 1212.0FPR1, IL13, CXADR, FASLG, FAS, TNFSF10
39aspartate439.0GFAP, FAS, FASLG, CXADR, IL13
40heparin43 28 24 1211.9IL13, CXADR, FASLG, FAS, FPR1
41cisplatin43 49 59 1211.7FASLG, GFAP, TERC, CXADR, FAS, DCT
42glutamate438.7TNFSF10, IL13, NUDT6, GFAP, FASLG, FABP7
43vegf438.7FASLG, BNIP3, FPR1, IL13, IL13RA1, FAS
44adenylate438.7CXADR, FASLG, DCT, GFAP, IL13
45thymidine43 249.7TERC, NUDT6, GFAP, FAS, FASLG, CXADR
46serine438.6CXADR, NUDT6, GFAP, TNFSF10, FAS, FASLG
47cysteine438.5IL13, CXADR, FASLG, FAS, DCT, GFAP
48nitric oxide43 24 1210.3FASLG, CXADR, IL13RA1, IL13, FPR1, BNIP3
49retinoic acid43 248.9CXADR, FPR1, IL13, FABP7, FASLG, FAS
50tyrosine437.5IL13RA1, IL13, FPR1, DCT, FASLG, ISG20

GO Terms for genes affiliated with Malignant Glioma

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Cellular components related to Malignant Glioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.8IL13, FASLG, FAS
2extracellular spaceGO:00056158.4IL13, IL13RA2, CXADR, FASLG, TNFRSF6B, TNFSF10

Biological processes related to Malignant Glioma according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:000692510.2FAS, FASLG
2necroptotic signaling pathwayGO:009752710.2FASLG, FAS
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:0200123910.1TNFSF10, FAS, FASLG
4positive regulation of immunoglobulin productionGO:000263910.0IL13RA1, IL13
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00069199.9FASLG, FAS, TNFSF10
6positive regulation of release of cytochrome c from mitochondriaGO:00902009.9BNIP3, TNFSF10
7cellular response to mechanical stimulusGO:00712609.8IL13, FAS, BNIP3
8apoptotic signaling pathwayGO:00971909.7TNFSF10, FAS, FASLG
9positive regulation of apoptotic processGO:00430659.4FAS, FASLG, BNIP3, TNFSF10
10apoptotic processGO:00069159.4FASLG, FAS, TNFRSF6B, TNFSF10, BNIP3
11signal transductionGO:00071659.3FAS, IL13RA2, IL13, FPR1, TNFSF10, FASLG
12defense response to virusGO:00516078.8CXADR, ISG20, BNIP3

Molecular functions related to Malignant Glioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:000516410.0FASLG, TNFSF10
2cytokine activityGO:00051259.5IL13, FASLG, TNFSF10

Products for genes affiliated with Malignant Glioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Malignant Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet