MCID: MLG068
MIFTS: 68

Malignant Glioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Malignant Glioma

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8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises... more...

MalaCards: Malignant Glioma, also known as glioma, is related to herpes simplex and astrocytoma. An important gene associated with Malignant Glioma is FABP7 (fatty acid binding protein 7, brain), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Apoptosis. The compounds cyclosporin h and concanamycin a have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and endothelial, and related mouse phenotypes are vision/eye and integument.

Disease Ontology:8 A cell type cancer that has material basis in glial cells and is located in brain or located in spine.

Description from OMIM:47 137800

Aliases & Classifications for Malignant Glioma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 35MeSH, 58SNOMED-CT, 47OMIM, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

malignant glioma 8 10 45 31 62
glioma 8 43 45 62
glioma, malignant, no icd-o subtype 8
malignant glioma - category 8
malignant neuroglial tumor 8
glioma, malignant 8
glial cell tumor 8
neuroglial tumor 8
glioma, nos 8
glioma nos 8
gliomas 8


Related Diseases for Malignant Glioma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Glioma family:

Benign Glioma

Diseases related to Malignant Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 307)
idRelated DiseaseScoreTop Affiliating Genes
1herpes simplex30.6ISG20, TNFRSF6B, TNFSF10
2astrocytoma30.5TERC, GFAP, TNFSF10, TNFRSF6B, FASLG, CXADR
3anaplastic astrocytoma30.5IL13RA1, TNFSF10, GFAP
4brain cancer30.4IL13, GFAP
5medulloblastoma30.3IL13RA2, TNFSF10, GFAP, NUDT6
6glioblastoma multiforme30.3GFAP, TNFSF10, DCT, FASLG, CXADR, IL13RA2
7retinoblastoma30.2TERC, GFAP, DCT, CXADR
8leukemia30.1TERC, NUDT6, TNFSF10, ISG20, FAS, FASLG
9hepatocellular carcinoma30.1TERC, TNFSF10, TNFRSF6B, FAS, FASLG, CXADR
10lung cancer30.1CXADR, FAS, TNFSF10, TERC
11colon cancer30.0CXADR, FASLG, FAS, TNFSF10
12subependymal giant cell astrocytoma29.9GFAP
13adenocarcinoma29.8TERC, BNIP3, NUDT6, TNFSF10, TNFRSF6B, FAS
14gastric adenocarcinoma29.8FASLG, FAS, TERC
15breast cancer29.8TERC, BNIP3, NUDT6, TNFSF10, ISG20, FAS
16stomach cancer29.7FASLG, FAS, TNFRSF6B, TERC
17multiple sclerosis29.7GFAP, TNFSF10, FASLG, IL13
18melanoma29.7TERC, NUDT6, TNFSF10, ISG20, DCT, FAS
19brain glioma10.8
20neuroblastoma10.8
21optic nerve glioma10.8
22brain stem glioma10.7
23chordoid glioma10.7
24optic pathway glioma10.7
25endotheliitis10.7
26neurofibromatosis10.6
27angiocentric glioma10.5
28spinal cord glioma10.5
29mixed glioma10.4
30hypoxia10.4
31oligodendroglioma10.4
32glioma somatic10.3
33encephalocele10.3
34encephaloceles10.3
35brain edema10.3
36third ventricle chordoid glioma10.3
37cerebritis10.2
38differentiating neuroblastoma10.2
39thyroiditis10.2
40childhood brain stem glioma10.2
41subependymal glioma10.2
42cholera10.2
43neuronitis10.2
44arteriovenous malformation10.2
45lymphopenia10.2
46meningioma10.2
47meningitis10.2
48wilms tumor10.2
49intracranial arteriovenous malformation10.2
50cytomegalovirus infection10.2

Graphical network of the top 20 diseases related to Malignant Glioma:



Diseases related to malignant glioma

Symptoms for Malignant Glioma

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47OMIM
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Clinical features from OMIM:

137800

Drugs & Therapeutics for Malignant Glioma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Malignant Glioma

Search NIH Clinical Center for Malignant Glioma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malignant Glioma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malignant Glioma:
ALD-451, bone marrow-derived cells for malignant glioma
Embryonic/Adult Cultured Cells Related to Malignant Glioma:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905

Genetic Tests for Malignant Glioma

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Anatomical Context for Malignant Glioma

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Malignant Glioma:

33
Brain, Endothelial, Bone, T cells, Monocytes, Bone marrow, Testes, Dentritic cells, Nk cells, Prostate, Breast, Lung, Liver, Colon, Skeletal muscle, Cortex

FMA organs/tissues related to Malignant Glioma:

14
Brain or

Animal Models for Malignant Glioma or affiliated genes

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37MGI
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Publications for Malignant Glioma

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52PubMed
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Articles related to Malignant Glioma:

(show top 50)    (show all 1013)
idTitleAuthorsYear
1
Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis. (24220141)
2013
2
Prognostic value of isocitrate dehydrogenase 1, O6-methylguanine-DNA methyltransferase promoter methylation, and 1p19q co-deletion in Japanese malignant glioma patients. (24160898)
2013
3
Re-irradiation in recurrent malignant glioma: prognostic value of [18F]FET-PET. (23054562)
2012
4
Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor I+2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele. (22424217)
2012
5
Phase II study of single-agent bevacizumab in Japanese patients with recurrent malignant glioma. (22844129)
2012
6
A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma. (22832897)
2012
7
Regulation of KEAP1 expression by promoter methylation in malignant gliomas and association with patient's outcome. (21173573)
2011
8
Cell surface receptors in malignant glioma. (21522029)
2011
9
O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation. (21365007)
2011
10
Safety and maximum tolerated dose of superselective intraarterial cerebral infusion of bevacizumab after osmotic blood-brain barrier disruption for recurrent malignant glioma. Clinical article. (20964595)
2011
11
Papillary endothelial hyperplasia presenting as recurrent malignant glioma. (20740304)
2011
12
Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells. (20946108)
2011
13
Human malignant glioma cells expressing functional formylpeptide receptor recruit endothelial progenitor cells for neovascularization. (20933627)
2010
14
MGMT promoter methylation in malignant gliomas: ready for personalized medicine? (19997073)
2010
15
Inositol-requiring enzyme 1alpha is a key regulator of angiogenesis and invasion in malignant glioma. (20702765)
2010
16
Lack of efficacy of bevacizumab plus irinotecan in children with recurrent malignant glioma and diffuse brainstem glioma: a Pediatric Brain Tumor Consortium study. (20479404)
2010
17
Hoechst 33342 induces radiosensitization in malignant glioma cells via increase in mitochondrial reactive oxygen species. (20540663)
2010
18
High-grade malignant glioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (20555079)
2010
19
Myricetin sensitizes malignant glioma cells to TRAIL-mediated apoptosis by down-regulation of the short isoform of FLIP and bcl-2. (19398149)
2009
20
Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas. (19686285)
2009
21
Combination of adenoviral virotherapy and temozolomide chemotherapy eradicates malignant glioma through autophagic and apoptotic cell death in vivo. (19277041)
2009
22
Indoleamine 2,3-dioxygenase as a new target for malignant glioma therapy. Laboratory investigation. (19199463)
2009
23
yuDetecting the percent of peripheral blood mononuclear cells displaying p-STAT-3 in malignant glioma patients. (19900287)
2009
24
Pharmacological inhibition of Bcl-2 family members reactivates TRAIL-induced apoptosis in malignant glioma. (17924059)
2008
25
Epigalocatechin-3-gallate (EGCG) downregulates PEA15 and thereby augments TRAIL-mediated apoptosis in malignant glioma. (18948169)
2008
26
Molecular targeted therapies and chemotherapy in malignant gliomas. (17906459)
2007
27
The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications. (17373877)
2007
28
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. (16818640)
2006
29
Convection-enhanced delivery of interleukin-13 receptor-directed cytotoxin for malignant glioma therapy. (16700620)
2006
30
Nordy, a synthetic lipoxygenase inhibitor, inhibits the expression of formylpeptide receptor and induces differentiation of malignant glioma cells. (16516855)
2006
31
Malignant glioma: the involvement of loss of allelic heterozygosity and PTEN mutations in a group of Malay patients. (16124450)
2005
32
Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Ralpha2. (15805299)
2005
33
Pivotal role of the cell death factor BNIP3 in ceramide-induced autophagic cell death in malignant glioma cells. (15205343)
2004
34
Expression of mutant non-cleavable Fas ligand on retrovirus packaging cells causes apoptosis of immunocompetent cells and improves prodrug activation gene therapy in a malignant glioma model. (12888123)
2003
35
Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene. (12651152)
2003
36
PTEN mutations in malignant gliomas and their relation with meningeal gliomatosis. (11678426)
2001
37
Monitoring activation of ribonuclease L by 2',5'-oligoadenylates using purified recombinant enzyme and intact malignant glioma cells. (11586885)
2001
38
A novel role for the urokinase-type plasminogen activator receptor in apoptosis of malignant gliomas. (10853019)
2000
39
Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: modulation of migration and invasion of human malignant glioma cells. (10569804)
1999
40
Adenovirus-mediated wild-type p53 expression induces apoptosis and suppresses tumorigenesis of experimental intracranial human malignant glioma. (10533721)
1999
41
Irradiation induced clonogenic cell death of human malignant glioma cells does not require CD95/CD95L interactions. (10697547)
1999
42
Soluble CD95 (Fas/APO-1) in malignant glioma: (no) implications for CD95-based immunotherapy? (10066095)
1998
43
Interferon-alpha enhances CD95L-induced apoptosis of human malignant glioma cells. (9670853)
1998
44
Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. (9484714)
1998
45
Biological profiles of malignant gliomas]. (7675550)
1995
46
Modulation of O6-methylguanine-DNA methyltransferase-mediated nimustine resistance in recurrent malignant gliomas by streptozotocin--a preliminary report. (7763050)
1995
47
Basic research for interferon gene therapy against malignant glioma]. (1598130)
1992
48
Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium. (2352010)
1990
49
Effect of tamoxifen on DNA synthesis and proliferation of human malignant glioma lines in vitro. (2224848)
1990
50
Deep vein thrombophlebitis and pulmonary embolism in patients with malignant gliomas. (2814622)
1989

Variations for Malignant Glioma

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Expression for genes affiliated with Malignant Glioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Glioma

Search GEO for disease gene expression data for Malignant Glioma.

Pathways for genes affiliated with Malignant Glioma

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Sources:
50PathCards, 54R&D Systems, 55Reactome, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 57SinoBiological, 5Cell Signaling Technology
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Pathways related to Malignant Glioma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0FASLG, FAS
2
Show member pathways
9.8FASLG, FAS, TNFSF10
3
Show member pathways
TRAIL signaling pathway38
9.8FASLG, FAS, TNFSF10
4
Show member pathways
Apoptosis and survival Apoptotic TNF family pathways60
9.8FASLG, FAS, TNFSF10
5
Show member pathways
9.8TNFSF10, FAS, FASLG
6
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.8TNFRSF6B, FAS, FASLG
7
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
9.7BNIP3, TNFSF10, FASLG
8
Show member pathways
Type III interferon signaling38
9.7IL13, IL13RA1, IL13RA2
9
Show member pathways
9.6FASLG, FAS, TNFRSF6B, TNFSF10
109.6TNFSF10, TNFRSF6B, FAS, FASLG
11
Show member pathways
Apoptosis and survival TNFR1 signaling pathway60
TWEAK Signaling Pathway38
Apoptosis Modulation by HSP7038
HIV-1 Nef- Negative effector of Fas and TNF-alpha38
9.6TNFSF10, TNFRSF6B, FAS, FASLG
12
Show member pathways
9.6TNFSF10, FAS, FASLG, IL13
13
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.2FASLG, FAS, TNFRSF6B, TNFSF10, BNIP3
14
Show member pathways
9.2NUDT6, TNFSF10, IL13RA2, IL13RA1, IL13
15
Show member pathways
9.2NUDT6, TNFSF10, IL13RA2, IL13RA1, IL13
16
Show member pathways
9.2NUDT6, TNFSF10, IL13RA2, IL13RA1, IL13
17
Show member pathways
9.2FAS, FASLG, CXADR, IL13
18
Show member pathways
8.8TNFSF10, TNFRSF6B, FAS, FASLG, IL13RA2, IL13RA1
19
Show member pathways
8.3NUDT6, GFAP, TNFSF10, TNFRSF6B, SOX11, IL13RA2

Compounds for genes affiliated with Malignant Glioma

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Malignant Glioma according to GeneCards/GeneDecks:

(show top 50)    (show all 98)
idCompoundScoreTop Affiliating Genes
1cyclosporin h45 2911.3FPR1, IL13
2concanamycin a45 6111.1TNFSF10, FAS, FASLG
33-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide4510.0FASLG, FAS, TNFSF10
4dutp4510.0GFAP, TNFSF10, FAS, FASLG
5adpribose4510.0FASLG, FAS, TNFSF10, TERC
6ifn-alpha4510.0IL13, FASLG, FAS, TNFSF10
7tetracycline45 1111.0FASLG, FAS, TNFSF10, GFAP
8rottlerin4510.0TNFSF10, FAS, FASLG, IL13
9adriamycin4510.0TERC, TNFSF10, FAS, FASLG
10suberoylanilide hydroxamic acid4510.0TNFSF10, FAS, FASLG
11sp 60012545 6110.9TNFSF10, FAS, FASLG, IL13
12cytarabine45 51 1111.9GFAP, TNFSF10, FAS, FASLG
13streptozotocin459.9TNFSF10, GFAP, NUDT6
14dmso459.8FPR1, TNFSF10, NUDT6, TERC
15bromodeoxyuridine459.8IL13, FASLG, GFAP, NUDT6
16ionomycin459.8FPR1, IL13, FASLG, FAS, TNFSF10
17doxycycline45 1110.8NUDT6, GFAP, TNFSF10, FASLG, IL13
18indomethacin45 29 61 1112.8TNFSF10, FAS, FASLG, IL13, FPR1
19agar459.8TERC, NUDT6, GFAP, FAS, FASLG
202-methoxyestradiol45 61 2411.7FASLG, ISG20, TNFSF10
21doxorubicin45 51 1111.7IL13, FASLG, FAS, TNFSF10, TERC
22genistein45 29 61 3 24 1114.7GFAP, TNFSF10, FAS, FASLG, FPR1
235fluorouracil459.6TERC, BNIP3, TNFSF10, FAS, FASLG
24cyclosporin a45 29 6111.6TNFSF10, FAS, FASLG, IL13, FPR1
25ceramide459.6BNIP3, TNFSF10, FAS, FASLG
26depsipeptide459.6TNFSF10, FAS, FASLG, CXADR
27paclitaxel45 51 1111.6BNIP3, GFAP, TNFSF10, FAS, FASLG
28wortmannin459.6NUDT6, TNFSF10, FAS, FASLG, IL13, FPR1
29pd 98,059459.6NUDT6, GFAP, TNFSF10, FAS, FASLG, IL13
305-aza-2deoxycytidine459.5BNIP3, TNFSF10, FAS, FASLG, MAGED4B
31fludarabine45 51 1111.5TNFSF10, FAS, FASLG
32sb 20358045 6110.5BNIP3, TNFSF10, FAS, FASLG, IL13, FPR1
33lactate459.3BNIP3, NUDT6, GFAP, FAS, FASLG, IL13
34butyrate459.2TERC, GFAP, TNFSF10, FAS, FASLG, CXADR
35estrogen459.0TERC, BNIP3, GFAP, TNFSF10, ISG20, FASLG
36phosphatidylinositol459.0BNIP3, NUDT6, TNFSF10, TNFRSF6B, FAS, FASLG
37oligonucleotide459.0TERC, ISG20, DCT, FAS, FASLG, FPR1
38dexamethasone45 51 29 1112.0GFAP, TNFSF10, FAS, FASLG, CXADR, IL13
39aspartate459.0GFAP, FAS, FASLG, CXADR, IL13
40heparin45 29 24 1111.9FPR1, IL13, CXADR, FASLG, FAS
41cisplatin45 51 61 1111.7TERC, GFAP, TNFSF10, DCT, FAS, FASLG
42glutamate458.7NUDT6, GFAP, TNFSF10, FASLG, FABP7, CXADR
43vegf458.7BNIP3, NUDT6, GFAP, TNFSF10, FAS, FASLG
44adenylate458.7IL13, CXADR, FASLG, DCT, GFAP
45thymidine45 249.7TERC, NUDT6, GFAP, FAS, FASLG, CXADR
46serine458.6NUDT6, GFAP, TNFSF10, FAS, FASLG, CXADR
47cysteine458.5NUDT6, GFAP, DCT, FAS, FASLG, CXADR
48nitric oxide45 24 1110.3BNIP3, NUDT6, TNFSF10, FAS, FASLG, CXADR
49retinoic acid45 248.9FPR1, TERC, NUDT6, GFAP, TNFSF10, DCT
50tyrosine457.5NUDT6, GFAP, TNFSF10, ISG20, DCT, FAS

GO Terms for genes affiliated with Malignant Glioma

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16Gene Ontology
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Cellular components related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.8IL13, FASLG, FAS
2extracellular spaceGO:0056158.4IL13, IL13RA2, CXADR, FASLG, TNFRSF6B, TNFSF10

Biological processes related to Malignant Glioma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1inflammatory cell apoptotic processGO:00692510.2FASLG, FAS
2necroptotic signaling pathwayGO:09752710.2FASLG, FAS
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.1FASLG, FAS, TNFSF10
4positive regulation of immunoglobulin productionGO:00263910.0IL13, IL13RA1
5activation of cysteine-type endopeptidase activity involved in apoptotic processGO:0069199.9FASLG, FAS, TNFSF10
6positive regulation of release of cytochrome c from mitochondriaGO:0902009.9TNFSF10, BNIP3
7cellular response to mechanical stimulusGO:0712609.8BNIP3, FAS, IL13
8apoptotic signaling pathwayGO:0971909.7FASLG, FAS, TNFSF10
9positive regulation of apoptotic processGO:0430659.4BNIP3, TNFSF10, FAS, FASLG
10apoptotic processGO:0069159.4BNIP3, TNFSF10, TNFRSF6B, FAS, FASLG
11signal transductionGO:0071659.3TNFSF10, FAS, FASLG, IL13RA2, IL13, FPR1
12defense response to virusGO:0516078.8BNIP3, ISG20, CXADR

Molecular functions related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tumor necrosis factor receptor bindingGO:00516410.0FASLG, TNFSF10
2cytokine activityGO:0051259.5IL13, FASLG, TNFSF10

Products for genes affiliated with Malignant Glioma

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  • Antibodies
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Sources for Malignant Glioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet