MCID: MLG068
MIFTS: 58

Malignant Glioma malady

Summaries for Malignant Glioma

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises... more...

MalaCards: Malignant Glioma, also known as glioma, is related to astrocytoma and brain cancer. An important gene associated with Malignant Glioma is LGI1 (leucine-rich, glioma inactivated 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include brain or, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology:8 A cell type cancer that has material basis in glial cells and is located in brain or located in spine.

Description from OMIM:47 137800

Aliases & Classifications for Malignant Glioma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 43NIH Rare Diseases, 57SNOMED-CT, 35MeSH, 47OMIM, 40NCIt
See all sources

Aliases & Descriptions:

malignant glioma 8 10 45 31 61
glioma 8 43 45 61
glioma, malignant, no icd-o subtype 8
malignant glioma - category 8
malignant neuroglial tumor 8
glioma, malignant 8
neuroglial tumor 8
glial cell tumor 8
glioma, nos 8
glioma nos 8
gliomas 8


Related Diseases for Malignant Glioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Malignant Glioma family:

benign glioma

Diseases related to Malignant Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.7IL13RA2, IL13, GFAP, TERC, TNFRSF6B, MAGED4B
2brain cancer30.4LGI1, MSI1, TERC, GFAP, IL13RA2, TNFSF10
3anaplastic astrocytoma30.3GFAP, IL13RA1, TNFSF10
4adenocarcinoma30.0IL13RA2, TNFSF10, BNIP3, FAS, ACSL5, TERC
5adenoma30.0ACSL5, TERC
6ependymoma30.0GFAP, TERC
7subependymal giant cell astrocytoma29.7GFAP
8brain glioma10.7
9chordoid glioma10.7
10optic pathway glioma10.7
11neurofibromatosis10.6
12spinal cord glioma10.5
13hypoxia10.4
14glioma somatic10.4
15n syndrome10.3
16encephalocele10.3
17brain edema10.2
18nasal encephalocele10.2
19third ventricle chordoid glioma10.2
20subependymal glioma10.2
21cholera10.1
22arteriovenous malformation10.1
23wilms tumor10.1
24intracranial arteriovenous malformation10.1
25cytomegalovirus infection10.1
26adult brainstem mixed glioma10.1
27gliosarcoma10.1
28diencephalic syndrome10.1
29central nervous system lymphoma10.1
30vaccinia10.1
31childhood optic nerve glioma10.1
32acoustic neuroma10.1
33limbic encephalitis10.1
34encephaloceles10.1
35glioma susceptibility 510.1
36glioma susceptibility 210.1
37myokymia10.1
38nasal glial heterotopia10.1
39pituitary tumors10.1
40syringomyelia10.0
41tuberous sclerosis10.0
42maple syrup urine disease10.0
43alexander disease10.0
44measles10.0
45pleomorphic xanthoastrocytoma10.0
46acute leukemia10.0
47stomatitis10.0
48central nervous system lymphoma, primary10.0
49oligoastrocytoma10.0
50visual pathway and hypothalamic glioma, childhood10.0

Graphical network of the top 20 diseases related to Malignant Glioma:



Diseases related to malignant glioma

Clinical Features for Malignant Glioma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

137800

Drugs & Therapeutics for Malignant Glioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Glioma

Drug clinical trials:

Search ClinicalTrials for Malignant Glioma

Search NIH Clinical Center for Malignant Glioma

Search CenterWatch for Malignant Glioma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malignant Glioma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malignant Glioma:
ALD-451, bone marrow-derived cells for malignant glioma
Embryonic/Adult Cultured Cells Related to Malignant Glioma:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905

Genetic Tests for Malignant Glioma

Anatomical Context for Malignant Glioma

Sources:
14FMA
See all sources

FMA organs/tissues related to Malignant Glioma:

14
Brain or

Animal Models for Malignant Glioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Malignant Glioma

Sources:
51PubMed
See all sources

Articles related to Malignant Glioma:

(show top 50)    (show all 1088)
idTitleAuthorsYear
1
Mutant tristetraprolin: a potent inhibitor of malignant glioma cell growth. (23525947)
2013
2
Calcineurin regulates nuclear factor I dephosphorylation and activity in malignant glioma cell lines. (23839947)
2013
3
A prospective phase II single-institution trial of sunitinib for recurrent malignant glioma. (22832897)
2012
4
Demethoxycurcumin Retards Cell Growth and Induces Apoptosis in Human Brain Malignant Glioma GBM 8401 Cells. (22454662)
2012
5
Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG-ODN) in malignant glioma. (22639162)
2012
6
Ridaforolimus for patients with progressive or recurrent malignant glioma: a perisurgical, sequential, ascending-dose trial. (22037923)
2012
7
A phase I/II clinical trial investigating the adverse and therapeutic effects of a postoperative autologous dendritic cell tumor vaccine in patients with malignant glioma. (21715171)
2011
8
A phase I trial of the farnesyl transferase inhibitor, SCH 66336, with temozolomide for patients with malignant glioma. (21735117)
2011
9
Human malignant glioma cells expressing functional formylpeptide receptor recruit endothelial progenitor cells for neovascularization. (20933627)
2010
10
Characterization and outcomes of infratentorial malignant glioma: a population-based study using the Surveillance Epidemiology and End-Results database. (20451276)
2010
11
Investigation of a plasmid containing a novel immunotoxin VEGF165-PE38 gene for antiangiogenic therapy in a malignant glioma model. (20127864)
2010
12
Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas. (19847810)
2010
13
Vandetanib alters the protein pattern in malignant glioma and normal brain in the BT4C rat glioma model. (20811710)
2010
14
Bevacizumab is active as a single agent against recurrent malignant gliomas. (20332478)
2010
15
Targeting integrins in malignant glioma. (20820929)
2010
16
Expression and clinical significance of EGFL7 in malignant glioma. (20213100)
2010
17
Application of therapeutic insonation to malignant glioma cells and facilitation by echo-contrast microbubbles of levovist. (19331155)
2009
18
Imaging of integrin alpha(v)beta(3) expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography. (19401596)
2009
19
Differential effect of imatinib and synergism of combination treatment with chemotherapeutic agents in malignant glioma cells. (19159435)
2009
20
The Guanine Nucleotide Exchange Factor SWAP-70 Modulates the Migration and Invasiveness of Human Malignant Glioma Cells. (19956392)
2009
21
Fibulin-3 is uniquely upregulated in malignant gliomas and promotes tumor cell motility and invasion. (19887559)
2009
22
Proteasome inhibition by bortezomib does not translate into efficacy on two malignant glioma xenografts. (18949434)
2008
23
Antiangiogenic therapy in malignant gliomas. (18841047)
2008
24
Bevacizumab in recurrent malignant glioma. (18541118)
2008
25
Glioma stem cells are more aggressive in recurrent tumors with malignant progression than in the primary tumor, and both can be maintained long-term in vitro. (18940013)
2008
26
Combination therapy for malignant glioma based on PTEN status. (18983237)
2008
27
Tumor-specific targeting of sodium borocaptate (BSH) to malignant glioma by transferrin-PEG liposomes: a modality for boron neutron capture therapy. (18219552)
2008
28
Distinct patterns of hypoxic expression of carbonic anhydrase IX (CA IX) in human malignant glioma cell lines. (16944313)
2007
29
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells. (17449721)
2007
30
Aberrant Stat3 signaling by interleukin-4 in malignant glioma cells: involvement of IL-13Ralpha2. (15805299)
2005
31
Modeling prognosis for patients with malignant astrocytic gliomas: quantifying the expression of multiple genetic markers and clinical variables. (16212813)
2005
32
Apoptosis induction with 5-fluorocytosine/cytosine deaminase gene therapy for human malignant glioma cells mediated by adenovirus. (15015777)
2004
33
Mismatch repair protein hMSH2 in primary drug resistance in in vitro human malignant gliomas. (15481721)
2004
34
Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR. (12874024)
2003
35
Roles of membrane type 1 matrix metalloproteinase and tissue inhibitor of metalloproteinases 2 in invasion and dissemination of human malignant glioma. (11235952)
2001
36
Regulation of brain fatty acid-binding protein expression by differential phosphorylation of nuclear factor I in malignant glioma cell lines. (10896661)
2000
37
Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53. (11223987)
2000
38
Interferon-alpha enhances CD95L-induced apoptosis of human malignant glioma cells. (9670853)
1998
39
Transgene expression in malignant glioma using a replication-defective adenoviral vector containing the Egr-1 promoter: activation by ionizing radiation or uptake of radioactive iododeoxyuridine. (9681412)
1998
40
Activity of fotemustine in medulloblastoma and malignant glioma xenografts in relation to O6-alkylguanine-DNA alkyltransferase and alkylpurine-DNA N-glycosylase activity. (9516937)
1998
41
Inhibitory effects of phenylbutyrate on the proliferation, morphology, migration and invasiveness of malignant glioma cells. (9524087)
1998
42
Angiostatin suppresses malignant glioma growth in vivo. (9788618)
1998
43
Localization of aberrant messenger RNA of epidermal growth factor receptor (EGFR) in malignant glioma. (9216693)
1997
44
Prospective study of postoperative magnetic resonance imaging in patients with malignant gliomas. (9164220)
1997
45
Deletion and transfection analysis of the p15/MTS2 gene in malignant gliomas. (8526910)
1995
46
Expression and localization of messenger RNA and protein for monocyte chemoattractant protein-1 in human malignant glioma. (8189261)
1994
47
Amplification of multiple genes from chromosomal region 12q13-14 in human malignant gliomas: preliminary mapping of the amplicons shows preferential involvement of CDK4, SAS, and MDM2. (8044775)
1994
48
Strategy for planned radiotherapy of malignant gliomas: postoperative treatment with combinations of high dose proton irradiation and tumor seeking radionuclides. (1310961)
1992
49
Monoclonal antibodies to malignant human gliomas. (1384525)
1992
50
The effects of local and systemic interferon beta (Fiblaferon) on supratentorial malignant cerebral glioma--a phase II study. (1658686)
1991

Genetic Variations for Malignant Glioma

Expression for genes affiliated with Malignant Glioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malignant Glioma

Search GEO for disease gene expression data for Malignant Glioma.

Pathways for genes affiliated with Malignant Glioma

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 54Reactome
See all sources

Compounds for genes affiliated with Malignant Glioma

Sources:
45Novoseek, 24HMDB, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR
See all sources

Compounds related to Malignant Glioma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1vegf4511.7TNFSF10, FAS, IL13, IL13RA1, FPR1, GFAP
2retinoic acid45 2412.7TNFSF10, TERC, GFAP, FPR1, IL13, FABP7
3phosphatidylinositol4511.6BNIP3, TNFRSF6B, FAS, IL13, FPR1, TNFSF10
4nitric oxide45 11 2413.6FPR1, BNIP3, IL13RA1, IL13, FAS, TNFSF10
5sb 20358045 6012.5BNIP3, FAS, IL13, FPR1, TNFSF10
6glutamine4511.5GFAP, TNFSF10, IL13, FAS, PPAT
7fatty acid4511.5FAS, FABP7, TNFSF10, BNIP3, ACSL5
8cisplatin45 50 60 1114.4TERC, TNFSF10, FAS, PPAT, GFAP
9thymidine45 2412.4FAS, IL13RA1, GFAP, TERC, IL13
10ionomycin4511.3FPR1, IL13, FAS, TNFSF10
115-aza-2deoxycytidine4511.3TNFSF10, MAGED4B, FAS, BNIP3
125fluorouracil4511.3TNFSF10, FAS, TERC, BNIP3
13indomethacin45 60 29 1114.2IL13, FPR1, TNFSF10, FAS
14dutp4511.2TNFSF10, GFAP, FAS
15butyrate4511.2TERC, FAS, TNFSF10, GFAP
16glutamate4511.2FABP7, PPAT, GFAP
17paclitaxel45 50 1113.2BNIP3, FAS, GFAP, TNFSF10
18ifn-alpha4511.2TNFSF10, FAS, IL13
19doxycycline45 1112.2GFAP, TNFSF10, IL13
20rottlerin4511.1IL13, TNFSF10, FAS
21cyclosporin h45 2912.1FPR1, IL13
22tetracycline45 1112.1FAS, TNFSF10, GFAP
23pd 98,0594511.0TNFSF10, FAS, GFAP, IL13
24adpribose4511.0TERC, FAS, TNFSF10
25propentofylline4511.0FAS, GFAP
26sp 60012545 6012.0IL13, TNFSF10, FAS
27alpha-galactosylceramide4511.0TNFSF10, IL13
28wortmannin4511.0TNFSF10, IL13, FPR1, FAS
29cytarabine45 50 1113.0FAS, GFAP, TNFSF10
30doxorubicin45 50 1112.9TERC, IL13, FAS, TNFSF10
31adriamycin4510.8TERC, TNFSF10, FAS
32dexamethasone45 50 29 1113.8FPR1, GFAP, TNFSF10, FAS, IL13

GO Terms for genes affiliated with Malignant Glioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.2LGI1, IL13RA2, IL13, EFEMP1, TNFRSF6B, TNFSF10

Biological processes related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.2TNFSF10, FAS, IL13, IL13RA2, FPR1, LRRN2
2cellular response to mechanical stimulusGO:07126010.7BNIP3, FAS, IL13
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.4TNFSF10, FAS

Molecular functions related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:00489610.7IL13RA2, IL13RA1
2receptor activityGO:00487210.7LRRN2, FPR1, FAS, TNFRSF6B

Products for genes affiliated with Malignant Glioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Malignant Glioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet