MCID: MLG068
MIFTS: 66

Malignant Glioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Malignant Glioma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises... more...

MalaCards: Malignant Glioma, also known as glioma, is related to astrocytoma and herpes simplex. An important gene associated with Malignant Glioma is LGI1 (leucine-rich, glioma inactivated 1), and among its related pathways are Rho Family GTPases and PEDF Induced Signaling. The compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include brain or, brain and endothelial, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Disease Ontology:8 A cell type cancer that has material basis in glial cells and is located in brain or located in spine.

Description from OMIM:46 137800

Aliases & Classifications for Malignant Glioma

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 34MeSH, 46OMIM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

malignant glioma 8 10 44 30 60
glioma 8 42 44 60
glioma, malignant, no icd-o subtype 8
malignant glioma - category 8
malignant neuroglial tumor 8
glioma, malignant 8
neuroglial tumor 8
glial cell tumor 8
glioma, nos 8
glioma nos 8
gliomas 8


Related Diseases for Malignant Glioma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Glioma family:

Benign Glioma

Diseases related to Malignant Glioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma30.6TNFSF10, TNFRSF6B, MAGED4B, IL13, IL13RA2, GFAP
2herpes simplex30.5TNFRSF6B, TNFSF10
3brain cancer30.4TNFSF10, LGI1, MSI1, TERC, GFAP, IL13RA2
4glioblastoma multiforme30.4TNFSF10, IL13, IL13RA1, IL13RA2, GFAP, LGI1
5medulloblastoma30.2GFAP, IL13RA2, TNFSF10
6adenocarcinoma30.0BNIP3, TNFSF10, TNFRSF6B, FAS, IL13RA2, ACSL5
7breast cancer30.0BNIP3, TNFSF10, FABP7, FAS, PPAT, TERC
8adenoma30.0TERC, ACSL5
9lung cancer30.0BNIP3, TNFSF10, FAS, PPAT, TERC
10melanoma29.9TNFSF10, FAS, PPAT, MAGED4B, TERC
11multiple sclerosis29.6TNFSF10, IL13, GFAP
12subependymal giant cell astrocytoma29.6GFAP
13neuroblastoma10.7
14optic nerve glioma10.7
15brain glioma10.7
16chordoid glioma10.6
17neurofibromatosis10.5
18third ventricle chordoid glioma10.5
19spinal cord glioma10.5
20mixed glioma10.4
21oligodendroglioma10.4
22differentiating neuroblastoma10.3
23glioma somatic10.3
24brain edema10.2
25cerebritis10.2
26childhood brain stem glioma10.2
27leukemia10.2
28subependymal glioma10.2
29thyroiditis10.2
30retinoblastoma10.2
31cholera10.1
32arteriovenous malformation10.1
33neuronitis10.1
34lymphopenia10.1
35malignant ependymoma10.1
36meningioma10.1
37meningitis10.1
38adult brainstem mixed glioma10.1
39gliosarcoma10.1
40optic pathway glioma10.1
41central nervous system lymphoma10.1
42vaccinia10.1
43arachnoiditis10.1
44childhood optic nerve glioma10.1
45acoustic neuroma10.1
46hepatocellular carcinoma10.1
47neuroma10.1
48pertussis10.1
49rhabdomyosarcoma10.1
50syringomyelia10.0

Graphical network of the top 20 diseases related to Malignant Glioma:



Diseases related to malignant glioma

Clinical Features for Malignant Glioma

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Sources:
46OMIM
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Clinical features from OMIM:

137800

Drugs & Therapeutics for Malignant Glioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Glioma

Drug clinical trials:

Search ClinicalTrials for Malignant Glioma

Search NIH Clinical Center for Malignant Glioma

Search CenterWatch for Malignant Glioma

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Malignant Glioma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Malignant Glioma:
ALD-451, bone marrow-derived cells for malignant glioma
Embryonic/Adult Cultured Cells Related to Malignant Glioma:
Bone marrow-derived ALDH+ cells (ALD), PMID: 10430905

Genetic Tests for Malignant Glioma

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Anatomical Context for Malignant Glioma

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Malignant Glioma:

32
Brain, Endothelial, Bone, T cells, Monocytes, Spinal cord, Bone marrow, Nk cells, Dentritic cells, Myeloid, Testes, Prostate, Breast, Lung, Liver, Colon, Skeletal muscle, Cortex

FMA organs/tissues related to Malignant Glioma:

14
Brain or

Animal Models for Malignant Glioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Glioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.2MSI1, BNIP3, SOX11, TNFSF10, FABP7, FAS
2MP:001076812.1EFEMP1, PPME1, FAS, TNFSF10, SOX11, IL13
3MP:000538711.8SOX11, TNFSF10, FAS, EFEMP1, IL13, IL13RA1
4MP:000539711.6BNIP3, SOX11, TNFSF10, FAS, EFEMP1, IL13
5MP:000538111.2SOX11, FAS, EFEMP1, IL13, FPR1, GFAP
6MP:000118611.0LGI1, TERC, EFEMP1, FAS
7MP:000538810.9SOX11, FAS, PPME1, IL13, IL13RA1, TERC

Publications for Malignant Glioma

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Sources:
50PubMed
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Articles related to Malignant Glioma:

(show top 50)    (show all 1111)
idTitleAuthorsYear
1
Long-term treatment with temozolomide in malignant glioma. (24063865)
2014
2
Predictive significance of mean apparent diffusion coefficient value for responsiveness of temozolomide-refractory malignant glioma to bevacizumab: preliminary report. (23354833)
2013
3
Post-traumatic malignant glioma in a pregnant woman: case report and review of the literature. (24067777)
2013
4
Enhanced induction of cell cycle arrest and apoptosis via the mitochondrial membrane potential disruption in human U87 malignant glioma cells by aloe emodin. (23869465)
2013
5
The cellular origin for malignant glioma and prospects for clinical advancements. (22616703)
2012
6
Temozolomide loaded PLGA-based superparamagnetic nanoparticles for magnetic resonance imaging and treatment of malignant glioma. (22486964)
2012
7
Expression of FMS-like tyrosine kinase 3 ligand by oncolytic herpes simplex virus type I prolongs survival in mice bearing established syngeneic intracranial malignant glioma. (22653387)
2012
8
Papillary endothelial hyperplasia presenting as recurrent malignant glioma. (20740304)
2011
9
Using bevacizumab in the fight against malignant glioma: first results in Asian patients. (21813894)
2011
10
RNA interference against SPARC promotes the growth of U-87MG human malignant glioma cells. (22866161)
2011
11
A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03. (21377994)
2011
12
Isolated angiitis of the central nervous system with tumor-like lesion, mimicking brain malignant glioma: a case report and review of the literature. (21867556)
2011
13
Low peripheral lymphocyte count before focal radiotherapy plus concomitant temozolomide predicts severe lymphopenia during malignant glioma treatment. (20805645)
2010
14
A cystic meningioma misdiagnosed as malignant glioma by radiologic and intraoperative histological examinations. (21046313)
2010
15
Treatment with bevacizumab plus carboplatin for recurrent malignant glioma. (20559095)
2010
16
Clinical and biological significance of forkhead class box O 3a expression in glioma: mediation of glioma malignancy by transcriptional regulation of p27kip1. (19911116)
2010
17
Apoptotic effects of I^-mangostin from the fruit hull of Garcinia mangostana on human malignant glioma cells. (21139533)
2010
18
Exploiting cyclooxygenase-(in)dependent properties of COX-2 inhibitors for malignant glioma therapy. (20879982)
2010
19
Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas. (19686285)
2009
20
Localized BCNU chemotherapy and the multimodal management of malignant glioma. (19210148)
2009
21
Novel antitumor effect of carboplatin delivered by intracerebral microinfusion in a rat malignant glioma model. (20035131)
2009
22
Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death. (19416948)
2009
23
Superselective intraarterial cerebral infusion of bevacizumab: a revival of interventional neuro-oncology for malignant glioma. (20192120)
2009
24
Radiopathological characteristics of cerebellar malignant glioma in adults. (19856216)
2009
25
REIC/Dkk-3 induces cell death in human malignant glioma. (18443132)
2008
26
Candidate genes for the progression of malignant gliomas identified by microarray analysis. (17917751)
2008
27
BH3 mimetics reactivate autophagic cell death in anoxia-resistant malignant glioma cells. (18670645)
2008
28
The epidermal growth factor receptor in malignant gliomas: pathogenesis and therapeutic implications. (17373877)
2007
29
Use of interferon-alpha-induced dendritic cells in the therapy of patients with malignant brain gliomas. (18214316)
2007
30
Degree prediction of malignancy in brain glioma using support vector machines. (16446164)
2006
31
Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas. (16832099)
2006
32
Participation of an abnormality in the transforming growth factor-beta signaling pathway in resistance of malignant glioma cells to growth inhibition induced by that factor. (16871886)
2006
33
CD46 represents a target for adenoviral gene therapy of malignant glioma. (16716112)
2006
34
Individualized chemotherapy based on drug sensitivity and resistance assay and MGMT protein expression for patients with malignant glioma--analysis of 42 cases]. (17166381)
2006
35
Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. (16885346)
2006
36
Retargeting of adenoviral vector using basic fibroblast growth factor ligand for malignant glioma gene therapy. (16381193)
2005
37
Protein delivery of caspase-3 induces cell death in malignant C6 glioma, primary astrocytes and immortalized and primary brain capillary endothelial cells. (15690127)
2005
38
Expression and functional activity of osteoprotegerin in human malignant gliomas. (14504888)
2004
39
Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. (15256471)
2004
40
Cation selectivity and inhibition of malignant glioma Na+ channels by Psalmotoxin 1. (15253892)
2004
41
Okadaic-acid-induced apoptosis in malignant glioma cells. (15727425)
2003
42
Adenoviral p16/CDKN2 gene transfer to malignant glioma: role of p16 in growth, invasion, and senescence. (12883667)
2003
43
Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. (12546364)
2003
44
Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target. (12640683)
2003
45
Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. (11717408)
2001
46
Prognosis value of p53 gene and cellular proliferation factors in malignant supratentorial gliomas]. (11706441)
2001
47
Secreted Frizzled-related proteins inhibit motility and promote growth of human malignant glioma cells. (10980594)
2000
48
Antiproliferative effect of multiple autocrine loop blockade in human malignant glioma cell lines. (8532126)
1995
49
Enhanced repair of a cisplatin-damaged reporter chloramphenicol-O-acetyltransferase gene and altered activities of DNA polymerases alpha and beta, and DNA ligase in cells of a human malignant glioma following in vivo cisplatin therapy. (8126081)
1994
50
TM-1 cells from an established human malignant glioma cell line produce PDGF, TGF-alpha, and TGF-beta which cooperatively play a stimulatory role for an autocrine growth promotion. (7714549)
1994

Genetic Variations for Malignant Glioma

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Expression for genes affiliated with Malignant Glioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Glioma

Search GEO for disease gene expression data for Malignant Glioma.

Pathways for genes affiliated with Malignant Glioma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Malignant Glioma

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44Novoseek, 24HMDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR
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Compounds related to Malignant Glioma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1vegf4411.7GFAP, FPR1, IL13RA1, IL13, FAS, TNFSF10
2retinoic acid44 2412.7TNFSF10, FABP7, FAS, IL13, FPR1, GFAP
3phosphatidylinositol4411.6BNIP3, TNFSF10, TNFRSF6B, FAS, IL13, FPR1
4nitric oxide44 11 2413.6BNIP3, TNFSF10, FAS, IL13, IL13RA1, FPR1
5sb 20358044 5912.5BNIP3, TNFSF10, FAS, IL13, FPR1
6glutamine4411.5TNFSF10, FAS, PPAT, IL13, GFAP
7fatty acid4411.5BNIP3, TNFSF10, FABP7, FAS, ACSL5
8cisplatin44 49 59 1114.4TNFSF10, FAS, PPAT, GFAP, TERC
9thymidine44 2412.4TERC, GFAP, IL13RA1, IL13, FAS
10ionomycin4411.3TNFSF10, FAS, IL13, FPR1
115-aza-2deoxycytidine4411.3MAGED4B, FAS, TNFSF10, BNIP3
125fluorouracil4411.3BNIP3, TNFSF10, FAS, TERC
13indomethacin44 59 28 1114.2FPR1, IL13, FAS, TNFSF10
14dutp4411.2TNFSF10, FAS, GFAP
15butyrate4411.2TERC, GFAP, FAS, TNFSF10
16glutamate4411.2FABP7, PPAT, GFAP
17paclitaxel44 49 1113.2BNIP3, TNFSF10, FAS, GFAP
18ifn-alpha4411.2IL13, FAS, TNFSF10
19doxycycline44 1112.2GFAP, IL13, TNFSF10
20rottlerin4411.1IL13, FAS, TNFSF10
21cyclosporin h44 2812.1FPR1, IL13
22tetracycline44 1112.1TNFSF10, FAS, GFAP
23pd 98,0594411.0GFAP, IL13, FAS, TNFSF10
24adpribose4411.0TERC, FAS, TNFSF10
25propentofylline4411.0FAS, GFAP
26sp 60012544 5912.0IL13, FAS, TNFSF10
27alpha-galactosylceramide4411.0IL13, TNFSF10
28wortmannin4411.0TNFSF10, FAS, IL13, FPR1
29cytarabine44 49 1113.0TNFSF10, FAS, GFAP
30doxorubicin44 49 1112.9TERC, IL13, FAS, TNFSF10
31adriamycin4410.8TERC, FAS, TNFSF10
32dexamethasone44 49 28 1113.8TNFSF10, FAS, IL13, FPR1, GFAP

GO Terms for genes affiliated with Malignant Glioma

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16Gene Ontology
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Cellular components related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.2LGI1, IL13RA2, IL13, EFEMP1, TNFRSF6B, TNFSF10

Biological processes related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716511.2FAS, IL13, IL13RA2, FPR1, LRRN2, TNFSF10
2cellular response to mechanical stimulusGO:07126010.7IL13, FAS, BNIP3
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.4FAS, TNFSF10

Molecular functions related to Malignant Glioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine receptor activityGO:00489610.7IL13RA2, IL13RA1
2receptor activityGO:00487210.7LRRN2, FPR1, FAS, TNFRSF6B

Products for genes affiliated with Malignant Glioma

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Sources for Malignant Glioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet