Malignant Glioma malady

Wikipedia: A glioma is a type of tumor that starts in the brain or spine. It is called a glioma because it arises...⁴⁴ more...

MalaCards: Malignant Glioma, also known as glioma, is related to carcinoma and neuroblastoma. An important gene associated with Malignant Glioma is LRRN2 (leucine rich repeat neuronal 2), and among its related pathways are Apoptosis and Autophagy and Pathways in cancer. The compounds paclitaxel and serine have been mentioned in the context of this disorder. Affiliated tissues include brain or, bone marrow and whole blood, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology: A cell type cancer that has material basis in glial cells and is located in brain or located in spine.⁶

Aliases & Descriptions:

malignant glioma 6 32 43 glioma 6 7 30 8 32 43 malignant glioma (morphologic abnormality) 6 glioma nos (morphologic abnormality) 6 glioma, malignant, no icd-o subtype 6 gliomas (morphologic abnormality) 6 glioma (morphologic abnormality) 6

malignant glioma - category 6 malignant neuroglial tumor 6 glioma, malignant 6 glial cell tumor 6 neuroglial tumor 6 glioma, nos 6 glioma nos 6

Diseases related to malignant glioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 878)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	45.9	PIK3CB, PIK3CA, PIK3CG, LRIG1, RECK, CNTN2
2	neuroblastoma	43.2	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
3	lung carcinoma	42.6	PIK3CA, PIK3CG, RECK, RCVRN, PCNA, RB1
4	glioblastoma	41.8	PIK3CA, PIK3CG, RB1, SETD2, BSG, VHL
5	leukemia	40.8	PIK3CB, PIK3CA, PIK3CG, RECK, CNTN2, KIT
6	astrocytoma	40.2	PIK3CA, PIK3CG, RECK, KIT, VTN, PCNA
7	melanoma	39.6	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
8	prostatitis	39.4	PIK3CB, PIK3CA, PIK3CG, LRIG1, RECK, KIT
9	neuronitis	39.0	PIK3CB, PIK3CA, PIK3CG, RECK, CNTN2, KIT
10	brain cancer	38.8	PIK3CA, PIK3CG, RB1, SETD2, VEGFA, RAF1
11	hypoxia	38.4	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
12	adenocarcinoma	37.5	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
13	pancreatitis	37.0	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
14	cerebritis	36.6	PIK3CG, CNTN2, KITLG, VWF, VTN, PCNA
15	meningioma	36.6	PIK3CG, SFRP1, PCNA, RB1, SETD2, SEMA3A
16	medulloblastoma	36.4	PIK3CA, PIK3CG, KIT, SFRP1, SFRP2, PCNA
17	hepatocellular carcinoma	36.1	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, VWF
18	myeloid leukemia	35.8	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
19	thyroiditis	35.5	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
20	brain glioma	35.5	PCNA, RB1, VIM, BSG, BIRC5, CDKN2A
21	sarcoma	34.8	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
22	renal cell carcinoma	34.6	PIK3CA, KIT, SFRP1, PCNA, SETD2, VIM
23	colon cancer	34.5	PIK3CB, PIK3CA, PIK3CG, RECK, VWF, PCNA
24	anaplastic astrocytoma	34.0	PCNA, RB1, BSG, VEGFA, LGALS1, S100B
25	esophagitis	33.9	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
26	retinoblastoma	33.5	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
27	herpes simplex	33.3	PIK3CA, PIK3CG, RECK, CNTN2, PCNA, SERPINE1
28	acute myeloid leukemia	33.3	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
29	neurofibromatosis	32.6	RECK, KIT, KITLG, VHL, RAF1, S100B
30	oligodendroglioma	32.2	BRAF, CDKN2C, CDKN2B, CDKN2A, MGMT, TP73
31	gliosarcoma	31.8	KIT, KITLG, RB1, VIM, BRAF, BCKDHB
32	breast cancer	31.4	PIK3CA, RECK, SFRP2, MYC, BMP6, CDK6
33	ependymoma	31.2	VTN, RB1, VIM, VEGFA, BNIP3, BIRC5
34	prostate carcinoma	31.1	VEGFA, BMP6, PARP1, MMP9, GSTM1, GSTT1
35	neurofibroma	31.0	CNTN2, KIT, KITLG, VIM, VEGFA, BMP6
36	ptosis	30.8	BIRC5, BECN1, PARP1, BCL2, BAX, XIAP
37	hodgkin's lymphoma	30.7	PIK3CG, BSG, BCL2, BCL2L1, BCR, LGALS1
38	tuberous sclerosis	30.7	PIK3CB, PIK3CA, PIK3CG, PCNA, VIM, VHL
39	cholesterol	30.7	PIK3CB, PIK3CA, PIK3CG, RECK, KITLG, VWF
40	oligoastrocytoma	30.6	MGMT, FABP7, IDH1, TP53, PDGFB, PDGFRA
41	dna topoisomerase i	30.4	CNTN2, PARP1, XRCC5, JUN, CDK6, CDKN2A
42	wilms tumor	30.1	VWF, PCNA, SETD2, VIM, VHL, VEGFA
43	neuroectodermal tumors	30.0	KIT, KITLG, RB1, VIM, MYC, RAF1
44	nasopharyngitis	29.6	PIK3CA, PIK3CG, RECK, KIT, KITLG, SFRP2
45	papilloma	29.4	PCNA, RB1, RBL2, VIM, BRAF, VEGFA
46	gliosis	29.3	S100B, IL1A, IL6, MBP, IFNG, GJA1
47	squamous cell carcinoma	29.1	LGALS1, CD44, MMP19, MMP7, GSTP1, CCND1
48	dna topoisomerase ii	29.1	PCNA, MYC, BCL2L1, JUN, CDKN1A, CDK2
49	differentiating neuroblastoma	29.0	VTN, BCL2, MIR10B, IL6, MAPK1, CCND3
50	meningitis	28.9	PIK3CG, PCNA, RB1, VIM, VEGFA, BMP6

Approved drugs:

Drug clinical trials:

Cell-based therapeutics:

MalaCards organs/tissues related to malignant glioma:

²²

FMA organs/tissues related to malignant glioma:

¹¹

MGI Mouse Phenotypes related to malignant glioma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	17.6	PIK3CB, PIK3CA, PIK3CG, KIT, KITLG, VWF
2	nervous system phenotype	MP:0003631	16.6	LRIG1, RECK, CNTN2, KIT, KITLG, VWF
3	cellular phenotype	MP:0005384	15.6	PIK3CB, PIK3CA, PIK3CG, LRIG1, KIT, KITLG
4	growth/size phenotype	MP:0005378	15.5	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
5	hematopoietic system phenotype	MP:0005397	14.9	KIT, SFRP1, PCNA, BRAF, VHL, BNIP3
6	mortality/aging	MP:0010768	14.8	PIK3CB, PIK3CA, RECK, KITLG, VWF, SFRP1
7	integument phenotype	MP:0010771	14.3	PIK3CG, LRIG1, RECK, KIT, KITLG, RB1
8	behavior/neurological phenotype	MP:0005386	14.0	PIK3CA, CNTN2, KIT, RB1, SEMA3A, VIM
9	immune system phenotype	MP:0005387	13.9	KIT, VWF, SFRP1, SEMA3A, VIM, BSG
10	vision/eye phenotype	MP:0005391	13.7	PIK3CA, KIT, KITLG, RCVRN, RB1, RBL2
11	renal/urinary system phenotype	MP:0005367	13.3	KIT, BRAF, VHL, BMP7, CLCN3, ZFP36
12	embryogenesis phenotype	MP:0005380	13.2	PIK3CB, PIK3CA, RECK, KIT, SFRP1, SFRP2
13	normal phenotype	MP:0002873	12.9	LRIG1, VTN, SFRP2, RBL2, BRAF, VHL
14	muscle phenotype	MP:0005369	12.8	PIK3CA, PIK3CG, KIT, SFRP2, RB1, RBL2
15	digestive/alimentary phenotype	MP:0005381	12.7	LRIG1, KIT, KITLG, VWF, RB1, BRAF
16	skeleton phenotype	MP:0005390	12.6	PIK3CG, RECK, KIT, KITLG, SFRP1, RB1
17	limbs/digits/tail phenotype	MP:0005371	12.5	LRIG1, RECK, KIT, KITLG, SFRP1, SFRP2
18	cardiovascular system phenotype	MP:0005385	12.2	PIK3CB, PIK3CA, PIK3CG, RECK, KIT, KITLG
19	endocrine/exocrine gland phenotype	MP:0005379	12.1	LRIG1, SFRP2, RBL2, BMPR1A, BMPR1B, CLCN2
20	no phenotypic analysis	MP:0003012	11.9	SFRP1, SFRP2, PCNA, RB1, RBL2, SEMA3A
21	tumorigenesis	MP:0002006	11.8	PIK3CB, PIK3CA, LRIG1, KIT, KITLG, RB1
22	reproductive system phenotype	MP:0005389	11.8	PIK3CA, SFRP2, RBL2, VHL, VEGFA, BMP7
23	pigmentation phenotype	MP:0001186	11.8	KIT, KITLG, RB1, SEMA3C, BRAF, MYC
24	hearing/vestibular/ear phenotype	MP:0005377	11.7	KIT, KITLG, RB1, MYC, BMP7, BMPR1A
25	liver/biliary system phenotype	MP:0005370	11.3	RECK, KIT, VHL, VEGFA, CLCN3, ZFP36
26	respiratory system phenotype	MP:0005388	11.2	SEMA3A, BMPR1A, CDKN2D, ITGB3, IL13RA1, DYNC2H1
27	craniofacial phenotype	MP:0005382	11.2	LRIG1, KIT, KITLG, BMPR1A, BMPR1B, LAMA3
28	other phenotype	MP:0005395	11.1	RECK, KDR, CDKN2A, ITGB3, MMP14, FN1
29	adipose tissue phenotype	MP:0005375	9.1	PIK3CA, SFRP1, RB1, SERPINE1, BRAF, MYC

Articles related to malignant glioma:

(show top 50)    (show all 573)

id	Title	Authors	Year	Affiliating Genes
1	Regulation of KEAP1 expression by promoter methylatio n in malignant gliomas and association with patient's outcome. (21173573)	Muscarella L.A.... Parrella P.	2011	KEAP1
2	Transient receptor potential canonical channels are e ssential for chemotactic migration of human malignant gliomas. (21506118)	Bomben V.C.... Sontheimer H.	2011	TRPC1
3	RNA interference-mediated silencing of focal adhesion kinase inhibits growth of human malignant glioma xenograft in nude mice. (21247411)	Wang G.J.... Deng H.X.	2011	PTK2
4	Akt2 and Akt3 play a pivotal role in malignant glioma s. (20167810)	Mure H.... Nagahiro S.	2010	AKT2, AKT1, AKT3
5	Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cells. (19913408)	Jane E.P.... Pollack I.F.	2010	H2AFX
6	Combination therapy with Gamma Knife radiosurgery and antisense EGFR for malignant glioma in vitro and orthotopic xenografts. (20428813)	Li Y.... Kang C.	2010	EGFR
7	Role of a second chemotherapy in recurrent malignant glioma patients who progress on bevacizumab. (19332770)	Quant E.C.... Wen P.Y.	2009	VEGFA
8	Differential effect of imatinib and synergism of combination treatment with chemotherapeutic agents in malignant glioma cells. (19159435)	Ren H.... Yang B.	2009	KIT
9	Downregulation of Wnt2 and beta-catenin by siRNA suppresses malignant glioma cell growth. (18949017)	Pu P.... Jiang H.	2009	CTNNB1, WNT2
10	BNIP3 (Bcl-2 19 kDa interacting protein) acts as transcriptional repressor of apoptosis-inducing factor expression preventing cell death in human malignant gliomas. (19339613)	Burton T.R.... Gibson S.B.	2009	HDAC1, AIFM1, BNIP3
11	Antagonism of the mammalian target of rapamycin selec tively mediates metabolic effects of epidermal growth factor receptor inhibitio n and protects human malignant glioma cells from hypoxia-induced cell death. (19416948)	Ronellenfitsch M.W.... Steinbach J.P.	2009	EGFR
12	The role of fascin in the migration and invasiveness of malignant glioma cells. (18283337)	Hwang J.H.... Rutka J.T.	2008	FSCN1
13	Specific mTOR inhibitor rapamycin enhances cytotoxicity induced by alkylating agent 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nit rosourea (ACNU) in human U251 malignant glioma cells. (17390104)	Tanaka K.... Kohmura E.	2007	EGFR, PTEN, CDKN1A
14	Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. (17786305)	Fujiwara K.... Kondo Y.	2007	EGFR
15	Effects of PTEN gene on human malignant glioma growth in vitro (17760247)	Li P.... Lin C.L.	2007	PTEN
16	A rare case of malignant glioma suspected to have ari sen from a cavernous sinus. (18095135)	Taomoto K.... Nakazato Y.	2007	GFAP
17	Gene delivery into malignant glioma by infectivity-enhanced adenovirus: in vivo versus in vitro models. (17522331)	van Houdt W.J.... Haviv Y.S.	2007	CXADR
18	Spontaneous immune responses against glioma-associated antigens in a long term survivor with malignant glioma. (18093336)	Ueda R.... Okada H.	2007	EPHA2, IL13RA2
19	Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. (17616690)	Kim E.H.... Choi K.S.	2007	BCL2, SOD2, BCL2L1
20	Identification of expressed genes characterizing long-term survival in malignant glioma patients. (16652150)	Yamanaka R.... Nishio K.	2006	DDR1, FGFBP2
21	Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy. (15897911)	Liu G.... Yu J.S.	2005	DCT
22	Histone deacetylase inhibitors, N-butyric acid and trichostatin A, induce caspase-8- but not caspase-9-dependent apoptosis in human malignant glioma cells. (15809727)	Komata T.... Tanaka R.	2005	CASP8, HDAC9, CASP9
23	Targeted molecular therapy of malignant gliomas. (15865884)	Kesari S.... Wen P.Y.	2005	EGFR
24	Cerebrospinal fluid (vascular endothelial growth factor) and serologic (recoverin) tumor markers for malignant glioma. (15153841)	Sampath P.... Stopa E.G.	2004	VEGFA, RCVRN
25	Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death. (14996711)	Steinbach J.P.... Weller M.	2004	EGFR, MAPK1, PIK3CA
26	Trial of targeting therapy against malignant glioma u sing monoclonal antibody. (15129587)	Takahashi H.... Teramoto A.	2004	EGF
27	Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells. (12874004)	Shingu T.... Tsuchiya M.	2003	CASP3, PIK3CG
28	Refined mapping of 1q32 amplicons in malignant gliomas confirms MDM4 as the main amplification target. (12640683)	Riemenschneider M.J.... Reifenberger G.	2003	MDM4
29	NF-kappaB-independent actions of sulfasalazine dissociate the CD95L- and Apo2L/TRAIL-dependent death signaling pathways in human malignant glioma cells. (12934082)	Hermisson M.... Weller M.	2003	NFKBIA, FAS, TNFRSF10A
30	Expression of mutant non-cleavable Fas ligand on retrovirus packaging cells causes apoptosis of immunocompetent cells and improves prodrug activation gene therapy in a malignant glioma model. (12888123)	Nafe C.... Rainov N.G.	2003	FAS
31	Expression of lymphocyte-specific chemokines in human malignant glioma: Essential role of LARC in cellular immunity of malignant glioma. (12239608)	Kimura T.... Ushio Y.	2002	CCL20, CCL17, CCL18
32	Induction and intracellular regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) mediated apotosis in human malignant glioma cells. (11221847)	Hao C.... Petruk K.C.	2001	TNFSF10, TNFRSF10D, TNFRSF10C
33	Sensitization of human malignant glioma cell lines to tumor necrosis factor-induced apoptosis by cisplatin. (11451200)	Duan L.... Hirakawa K.	2001	IL6
34	Antisense-mediated inhibition of the bcl-2 gene induces apoptosis in human malignant glioma. (10825522)	Julien T.... Ryken T.	2000	BCL2
35	Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. (11127823)	Yamashita Y.... Yamamoto T.T.	2000	ACSL5
36	2-5A antisense telomerase RNA therapy for intracranial malignant gliomas. (10969793)	Mukai S.... Kondo S.	2000	TERC
37	Effects of radiation on a three-dimensional model of malignant glioma invasion. (10571424)	Bauman G.S.... Del Maestro R.F.	1999	CD36
38	Tumor suppressor gene alterations in malignant gliomas: histopathological associations and prognostic evaluation. (10427138)	James C.D.... Scheithauer B.W.	1999	PTEN, CDKN2A
39	Evaluation of the malignancy of glioma using 11C-methionine positron emission tomography and proliferating cell nuclear antigen staining. (10682929)	Sato N.... Ogawa A.	1999	PCNA
40	Accumulation of mutant p53(V143A) modulates the growth, clonogenicity, and radiochemosensitivity of malignant glioma cells independent of endogenous p53 status. (10585266)	Bartussek C.... Weller M.	1999	TP53
41	Soluble CD95 (Fas/APO-1) in malignant glioma: (no) implications for CD95-based immunotherapy? (10066095)	Streffer J.R.... Weller M.	1998	FAS
42	Inhibitory effects of phenylbutyrate on the prolifera tion, morphology, migration and invasiveness of malignant glioma cells. (9524087)	Engelhard H.H.... Rozental J.	1998	MYC
43	The role of protein kinase C (PKC) in the evolution and proliferation of malignant gliomas, and the application of PKC inhibition as a novel approach to anti-glioma therapy. (9442212)	Bredel M.... Pollack I.F.	1997	DYT10
44	Usefulness of a mouse myelin basic protein promoter for gene therapy of malignant glioma: myelin basic protein promoter is strongly active in human malignant glioma cells. (9310141)	Miyao Y.... Ikenaka K.	1997	MBP, GFAP, PLP1
45	Antiproliferative effect of multiple autocrine loop blockade in human malignant glioma cell lines. (8532126)	Kurimoto M.... Takaku A.	1995	FGF2
46	Migration and adhesiveness of malignant glioma cells to fibronectin or vitronectin and their expression of integrin subunits (7543163)	Yamamoto H.... Hayakawa T.	1995	FN1, VTN
47	Increased expression of gelatinases A and B, matrilysin and TIMP-1 genes in human malignant gliomas (7630025)	Nakano A.... Miyazaki K.	1995	MMP2, MMP9, TIMP2
48	Epidermal growth factor receptor expression in human malignant glioma: in vitro and in vivo effects of application of monoclonal antibodies to the epidermal growth factor receptor. (8047692)	Westphal M.... Behnke J.	1994	EGFR
49	Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells: a model of glioblastoma multiforme pathophysiology. (7680247)	Goldman C.K.... Gillespie G.Y.	1993	EGFR, EGF, VEGFA
50	Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs. (8316628)	Allalunis-Turner M.J.... Mirzayans R.	1993	TP53

Genes related to malignant glioma according to GeneCards:

(show top 50)    (show all 411)

id	Symbol	Description	Score	GeneCards Section Context
1	LRRN2	leucine rich repeat neuronal 2	11.1	Publications, Summaries, Expressions
2	LGI1	leucine-rich, glioma inactivated 1	11.1	Summaries, Expressions
3	ACSL5	acyl-CoA synthetase long-chain family member 5	11.1	Publications, Summaries
4	EFEMP1	EGF containing fibulin-like extracellular matrix protein 1	11.1	Publications, Summaries
5	FABP7	fatty acid binding protein 7, brain	11.0	Publications
6	IL13RA2	interleukin 13 receptor, alpha 2	11.0	Publications
7	IL13RA1	interleukin 13 receptor, alpha 1	11.0	Publications
8	SOX11	SRY (sex determining region Y)-box 11	11.0	Publications
9	MAGED4B	melanoma antigen family D, 4B	11.0
10	ISG20	interferon stimulated exonuclease gene 20kDa	11.0	Publications
11	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	11.0	Publications
12	TNFRSF6B	tumor necrosis factor receptor superfamily, member 6b, decoy	11.0	Publications
13	FPR1	formyl peptide receptor 1	11.0	Publications
14	GFAP	glial fibrillary acidic protein	11.0	Publications
15	PPAT	phosphoribosyl pyrophosphate amidotransferase	11.0	Publications
16	CLCN2	chloride channel, voltage-sensitive 2	11.0
17	TERC	telomerase RNA component	11.0	Publications
18	MSI1	musashi homolog 1 (Drosophila)	11.0	Publications
19	PTEN	phosphatase and tensin homolog	11.0	Publications
20	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
21	THBS1	thrombospondin 1	11.0	Publications
22	CD80	CD80 molecule	11.0	Publications
23	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications
24	SLC9A1	solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1	11.0	Publications
25	RNASEL	ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)	11.0	Publications
26	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
27	DMBT1	deleted in malignant brain tumors 1	11.0	Publications
28	MTDH	metadherin	11.0
29	GJA1	gap junction protein, alpha 1, 43kDa	11.0	Publications
30	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	11.0	Publications
31	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0
32	CXADR	coxsackie virus and adenovirus receptor	11.0	Publications
33	PVR	poliovirus receptor	11.0	Publications
34	WNT2	wingless-type MMTV integration site family member 2	11.0	Publications
35	PLP1	proteolipid protein 1	11.0	Publications
36	PMEL	premelanosome protein	11.0
37	DCT	dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)	11.0	Publications
38	NES	nestin	11.0	Publications
39	DUSP19	dual specificity phosphatase 19	11.0	Publications
40	CCKBR	cholecystokinin B receptor	11.0
41	PLG	plasminogen	11.0	Publications
42	CFLAR	CASP8 and FADD-like apoptosis regulator	11.0	Publications
43	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
44	CCND2	cyclin D2	11.0	Publications
45	PTN	pleiotrophin	11.0	Publications
46	CCND3	cyclin D3	11.0	Publications, Functions
47	CD59	CD59 molecule, complement regulatory protein	11.0	Publications
48	CDK4	cyclin-dependent kinase 4	11.0	Publications
49	NUDT6	nudix (nucleoside diphosphate linked moiety X)-type motif 6	11.0	Publications
50	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications

Pathways related to malignant glioma according to GeneDecks:

(show top 50)    (show all 305)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and Autophagy3	12.9	MYC, BIRC5, BECN1, PARP1, BCL2, BCL2L1
2	Pathways in cancer20	12.9	PIK3CB, PIK3CA, PIK3CG, RB1, VEGFA, MYC
3	Focal adhesion20	12.5	PIK3CB, PIK3CA, PIK3CG, VWF, VTN, BRAF
4	Pancreatic Adenocarcinoma36	12.4	KIT, KITLG, RB1, SEMA3A, BRAF, BMP6
5	Glioblastoma Multiforme36	12.4	RB1, BRAF, RAF1, RAC1, CDK6, CDKN1A
6	Glioma Invasiveness36	12.3	KITLG, VTN, SEMA3A, BMP6, BMP7, CD44
7	Breast Cancer Regulation by Stathmin136	12.2	SEMA3A, BMP7, RAF1, RAC1, CDC42, ARHGEF6
8	Rho Family GTPases36	12.1	KIT, KITLG, SEMA3A, VIM, BMP6, BMP7
9	p53 Mediated Apoptosis36	12.0	KIT, KITLG, SEMA3A, BMP6, BMP7, KDR
10	Apoptosis20	12.0	PIK3CB, PIK3CA, PIK3CG, BCL2, BCL2L1, BAX
11	Cellular Apoptosis Pathway36	11.9	KIT, KITLG, SEMA3A, BMP6, BMP7, KDR
12	JNK Pathway36	11.8	KIT, KITLG, BMP6, BMP7, RAF1, RAC1
13	Angiogenesis3	11.7	RECK, VHL, KDR, ITGAV, ITGB3, ITGB5
14	Development_HGF signaling pathway41	11.6	PIK3CB, PIK3CA, RAF1, RAC1, SDC1, JUN
15	Cell adhesion_PLAU signaling41	11.6	PIK3CB, PIK3CA, VTN, SERPINE1, RAF1, MET
16	Akt Signaling36	11.5	PIK3CG, KIT, SEMA3A, BMP7, BMPR1A, BMPR1B
17	VEGF Signaling Pathway34	11.5	VEGFA, RAF1, KDR, ITGAV, ITGB3, ITGB5
18	Activation of PKC through GPCR36	11.4	KIT, KITLG, SEMA3A, BMP6, BMP7, RAF1
19	Cell adhesion PLAU signaling10	11.4	PIK3CB, PIK3CA, VTN, SERPINE1, RAF1, MET
20	Apoptosis and survival Apoptotic TNF-family pathways10	11.3	BCL2, BCL2L1, BAX, XIAP, FASLG, FADD
21	Cytoskeleton remodeling FAK signaling10	11.3	PIK3CB, RAF1, KDR, CDC42, FN1, GSK3B
22	Neurotrophin signaling pathway20	11.3	PIK3CB, PIK3CA, PIK3CG, BRAF, RAF1, RAC1
23	cAMP Pathway36	11.3	KIT, KITLG, SEMA3A, BRAF, BMP6, BMP7
24	UPA-UPAR Pathway36	11.2	VTN, SERPINE1, LAMA3, JUN, ITGAV, ITGB3
25	Hepatitis C20	11.0	PIK3CB, PIK3CA, PIK3CG, BRAF, RAF1, CDKN1A
26	Adipocytokines & Insulin Signaling37	11.0	PIK3CB, PIK3CG, BRAF, MTOR, GSK3B, AKT3
27	Colorectal cancer20	11.0	PIK3CB, PIK3CG, BRAF, RAC1, MSH2, MSH6
28	GPCR Pathway36	11.0	KIT, KITLG, SEMA3A, BRAF, BMP6, BMP7
29	Signal transduction PTEN pathway10	11.0	PIK3CB, PIK3CA, PCNA, RAF1, MTOR, JUN
30	Apoptotic Pathways in Synovial Fibroblasts36	11.0	KIT, KITLG, SEMA3A, BMP6, BMP7, KDR
31	MAPK Signaling36	11.0	KIT, KITLG, SEMA3A, BRAF, MYC, BMP6
32	ERK5 Signaling36	10.9	KIT, KITLG, SEMA3A, MYC, BMP6, BMP7
33	Cell cycle20	10.9	PCNA, RB1, RBL2, MYC, CDK6, CDKN1A
34	TNF Superfamily Pathway36	10.8	JUN, FADD, MAPK8, MAP2K4, MAPK14, CASP7
35	Measles20	10.8	PIK3CB, PIK3CA, PIK3CG, CDK6, CDK2, CDKN1B
36	p70S6K Signaling36	10.8	KIT, KITLG, SEMA3A, BMP6, BMP7, RAF1
37	Development_VEGF signaling via VEGFR2 - generic cascades41	10.8	PIK3CB, PIK3CA, VEGFA, RAF1, RAC1, JUN
38	MAPK signaling pathway20	10.7	BRAF, MYC, RAF1, RAC1, JUN, CDC42
39	GSK3 Signaling36	10.7	KIT, KITLG, SEMA3A, BMP6, BMP7, KDR
40	TGF-beta Signaling Pathways37	10.7	PIK3CB, PIK3CG, BRAF, MYC, RAF1, RAC1
41	Signal transduction_PTEN pathway41	10.6	PCNA, GSK3B, IGF1R, CASP9
42	Cell adhesion ECM remodeling10	10.6	VTN, SERPINE1, LAMA3, CD44, MMP1, MMP14
43	Apoptosis and survival TNFR1 signaling pathway10	10.6	BAX, XIAP, CFLAR, JUN, FADD, MAPK8
44	Cell adhesion_ECM remodeling41	10.6	VTN, SERPINE1, LAMA3, CD44, MMP1, MMP14
45	RAR-Gamma-RXR-Alpha Degradation36	10.5	BMP7, CD80, IL2, IL24, IL3, ANGPT1
46	STAT3 Pathway36	10.4	BRAF, MYC, BMP6, BMP7, BMPR1A, BMPR1B
47	NFAT in Immune Response36	10.2	KIT, KITLG, SEMA3A, BMP6, BMP7, KDR
48	Cytokine-cytokine receptor interaction20	10.0	KIT, KITLG, VEGFA, BMP7, BMPR1A, BMPR1B
49	TGF-beta signaling pathway20	9.8	RBL2, MYC, BMP6, BMP7, BMPR1A, BMPR1B
50	Influenza A20	9.4	PIK3CB, PIK3CA, PIK3CG, RAF1, CIITA, FURIN

Compounds related to malignant glioma according to GeneDecks:

(show top 50)    (show all 480)

id	Compound	Score	Top Affiliating Genes
1	paclitaxel32 34 9 9	19.4	PIK3CA, PIK3CG, KIT, KITLG, PCNA, RB1
2	serine32	15.9	PIK3CB, PIK3CA, PIK3CG, RECK, CNTN2, KIT
3	wortmannin32 42	16.8	PIK3CB, PIK3CA, PIK3CG, KITLG, VTN, SETD2
4	vegf32	14.7	PIK3CB, PIK3CA, PIK3CG, RECK, CNTN2, KIT
5	estrogen32	14.1	PIK3CB, VWF, PCNA, SETD2, SERPINE1, BSG
6	progesterone32 42 9 18 9	18.0	PIK3CA, KIT, PCNA, RB1, SETD2, BSG
7	steroid32	13.6	PIK3CB, PIK3CA, CNTN2, KIT, KITLG, RB1
8	cyclic amp32 18	14.2	RB1, SETD2, BRAF, KCNMA1, CIITA, ATF5
9	bromodeoxyuridine32	13.2	PIK3CA, CNTN2, KITLG, PCNA, RB1, VIM
10	butyrate32	12.4	KITLG, RCVRN, PCNA, RB1, SETD2, VIM
11	trastuzumab32 34 9 9	15.2	PIK3CA, PIK3CG, KIT, RAF1, BIRC5, KDR
12	ascorbic acid32 18	13.1	PIK3CG, PCNA, SETD2, BMP7, RAF1, RAC1
13	ribonucleic acid32	12.1	KIT, KITLG, MYC, BMP6, BMP7, CIITA
14	h2o232	12.1	PIK3CB, PIK3CG, CNTN2, KITLG, VWF, KEAP1
15	depsipeptide32	12.0	KITLG, RB1, BRAF, MYC, RAF1, BCL2
16	resveratrol32 9 18 9	14.9	PIK3CA, PIK3CG, PCNA, RB1, BSG, VEGFA
17	threonine32	11.9	RBL2, BMPR1A, BMPR1B, RAF1, MT3, XRCC5
18	egcg32	11.8	PIK3CG, RAF1, BCL2L1, XIAP, CDK6, CDK2
19	n acetylcysteine32	11.8	VWF, PCNA, SETD2, RAF1, BIRC5, KDR
20	dbc-amp32	11.7	VIM, BMP6, S100B, CDKN1B, FPR1, IL1B
21	chelerythrine32	11.7	PIK3CG, CFLAR, CDKN3, FN1, MBP, MAPK8
22	gp 13032	11.6	RECK, KIT, BMP6, BCL2L1, BCR, CDC25C
23	isoproterenol32 9 9	13.6	VIM, BRAF, RAF1, KCNMA1, FGF2, IL13
24	3,3-diindolylmethane32	11.6	VEGFA, BIRC5, PARP1, BAX, CFLAR, CDK6
25	taxane32	11.6	VEGFA, BIRC5, KDR, BCL2, MTOR, CDKN1A
26	tunicamycin32	11.5	PIK3CG, RECK, CD44, GRP, ANPEP, MAPK8
27	inositol32	11.5	PIK3CB, BCR, CDIPT, GSK3B, GRP, MBP
28	heparin32 9 18 9	14.4	PIK3CA, PIK3CG, RECK, KITLG, VWF, VTN
29	glycosaminoglycan32	11.4	VTN, CD36, CD44, AREG, FGF2, MET
30	quercetin32 42 9 18 9	15.4	PIK3CB, PIK3CA, PIK3CG, RAF1, BIRC5, PARP1
31	sulindac sulfide32	11.3	PCNA, BMP6, BCL2, BCL2L1, BAX, JUN
32	sodium nitroprusside32	11.2	VWF, PCNA, BMP6, BLVRB, KCNMA1, S100B
33	mg 13232 42	12.2	PIK3CG, PCNA, MYC, BIRC5, PARP1, KDR
34	batimastat32 42 9 9	14.1	CD36, MMP1, MMP11, MMP14, MMP19, MMP2
35	procollagen32	11.0	PCNA, VIM, BMP6, LGALS1, FURIN, CD36
36	mithramycin32	10.9	PIK3CG, MYC, BIRC5, CFLAR, JUN, CDKN1A
37	tgf beta132	10.9	KITLG, RBL2, SETD2, SERPINE1, BMP6, BMP7
38	cd 43732	10.8	MYC, PARP1, BCL2, BCL2L1, BAX, JUN
39	leucovorin32 34 9 9	13.4	VEGFA, IL3, FASLG, IFNA1, IFNA2, ERBB2
40	bcnu32	10.4	PARP1, CDKN2A, MGMT, GSTP1, GSTT1, IL2
41	sulforaphane32	10.3	PIK3CG, RB1, PARP1, KEAP1, JUN, CDKN1A
42	methylcellulose32	10.1	KIT, KITLG, CD59, FGF2, IL1A, IL3
43	salicylic acid32	10.0	PIK3CG, MYC, BCL2L1, MMP3, IL13, IL1RAPL2
44	s-nitroso-n-acetylpenicillamine32	9.9	PARP1, FN1, IL1B, IL8, ANXA5, MAPK14
45	ifn-alpha32	9.7	CDK2, CDKN2A, IL13, IL18, IL2, IL6
46	herbimycin a32 42	10.0	PIK3CG, KITLG, VTN, MYC, BMP6, RAF1
47	indomethacin32 9 9	11.0	PCNA, VIM, MYC, BMP6, RAF1, BLVRB
48	pdtc32	9.0	PIK3CA, PIK3CG, SETD2, RAF1, BIRC5, PARP1
49	ccl332	8.1	MMP9, IL13, IL18, IL1A, IL1B, IL6
50	prednisolone32 9 9	10.0	KITLG, VWF, MYC, BMP6, CDKN3, CD44

Cellular components related to malignant glioma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	15.9	PVR, EGFR, WT1, WWTR1, RHOH, SKIL
2	nucleus	GO:005634	15.2	NF2, NF1, RPS6KB1, RPS6, NOS2, SMAD7
3	plasma membrane	GO:005886	15.1	ULBP3, BRAF, BSG, VIM, SERPINE1, SFRP1
4	cytosol	GO:005829	13.7	STAT6, RNASEL, NFKBIA, NGFR, RPS6KB1, RPS6
5	integral to plasma membrane	GO:005887	12.2	PDGFRA, NGFR, PLAUR, SSTR2, DDR1, TNFSF10
6	nucleoplasm	GO:005654	12.1	PSMC4, WWTR1, SKIL, SKI, NGFR, SMAD7
7	cell surface	GO:009986	11.9	CSPG4, PDGFA, NGFR, RPS6KB1, PLAUR, PLAU
8	proteinaceous extracellular matrix	GO:005578	11.3	TNC, TNFRSF11B, DMBT1, SPARC, LTBP1, TGFB1
9	extracellular region	GO:005576	11.2	TIMP1, PLAT, NRP1, NTF3, SPARC, DDR1
10	cyclin-dependent protein kinase holoenzyme complex	GO:000307	10.7	CCND3, CCND2, CDK4, CDK2, CDKN1A, CDK6
11	membrane raft	GO:045121	10.5	TNF, TNFRSF1A, EGFR, HK1, PRKCA, CXADR
12	extracellular matrix	GO:031012	10.5	LTBP1, TIMP3, THBS1, TGFB2, DCN, SOD1
13	extracellular space	GO:005615	10.2	MMP7, VEGFA, SERPINE1, SEMA3C, SFRP2, SFRP1
14	platelet alpha granule lumen	GO:031093	10.0	PDGFB, EGF, TIMP1, THBS1, TGFB1, TGFB2
15	external side of plasma membrane	GO:009897	9.6	ANPEP, IFNG, ICAM1, TNF, CTSB, THBS1

Biological processes related to malignant glioma according to GeneDecks:

(show top 50)    (show all 82)

id	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:006915	13.8	SEMA3A, VIM, BNIP3, RAF1, RAC1, BIRC5
2	signal transduction	GO:007165	13.6	PIK3CB, KIT, KITLG, RCVRN, RAF1, BCR
3	virus-host interaction	GO:019048	13.0	RB1, VIM, BNIP3, BECN1, KDR, ULBP3
4	cell proliferation	GO:008283	12.6	KITLG, PCNA, RAF1, BCL2L1, LHX9, LGI1
5	induction of apoptosis by intracellular signals	GO:008629	12.0	BNIP3, MYC, BCL2, BCL2L1, BAX, XIAP
6	positive regulation of cell migration	GO:030335	11.9	VEGFA, KDR, FURIN, ITGAV, MMP14, FLT1
7	induction of apoptosis	GO:006917	11.6	BNIP3, BAX, CDKN2C, CDKN1B, CDKN2A, FASLG
8	positive regulation of gene expression	GO:010628	11.5	KIT, BRAF, VEGFA, MT3, CDC42, CD44
9	angiogenesis	GO:001525	11.5	PIK3CA, PIK3CG, SETD2, SERPINE1, VEGFA, KDR
10	activation of pro-apoptotic gene products	GO:008633	11.4	MYC, BCL2, BAX, FASLG, FADD, FAS
11	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	11.3	MYC, BAX, CDKN1B, CDKN2A, FASLG, FADD
12	nerve growth factor receptor signaling pathway	GO:048011	11.3	PIK3CB, PIK3CA, BRAF, RAF1, RAC1, MTOR
13	positive regulation of endothelial cell proliferation	GO:001938	11.3	VEGFA, BMP6, KDR, MTOR, JUN, ITGB3
14	response to ethanol	GO:045471	11.3	BCL2, MMP9, MGMT, IL13, IL4, CCL2
15	cell cycle arrest	GO:007050	11.3	RB1, MYC, MSH2, CDK6, CDKN1A, CDKN2C
16	G1 phase of mitotic cell cycle	GO:000080	11.2	RB1, RBL2, CDK6, CDKN1A, CDKN2C, CDKN2B
17	positive regulation of angiogenesis	GO:045766	11.2	SFRP2, SERPINE1, VEGFA, KDR, CHI3L1, MTDH
18	immune response	GO:006955	11.1	VTN, SEMA3C, BMP6, BMPR1A, RAET1E, ULBP1
19	response to wounding	GO:009611	11.1	VWF, RAC1, FN1, MET, MDK, F2
20	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.1	BRAF, KDR, CHI3L1, MT3, CD44, MIF
21	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	11.0	KIT, KDR, FLT1, FGFR1, ANGPT1, IGF1
22	positive regulation of fibroblast proliferation	GO:048146	11.0	MYC, JUN, CDK6, CDKN1A, CDK4, MIF
23	heart development	GO:007507	11.0	PCNA, RAF1, CASP7, CASP3, CASP8, GJA1
24	response to hypoxia	GO:001666	11.0	VEGFA, BNIP3, RAF1, BCL2, KCNMA1, MT3
25	protein autophosphorylation	GO:046777	10.9	KIT, KDR, MTOR, FLT1, FGFR1, FGFR4
26	anti-apoptosis	GO:006916	10.9	PIK3CA, BRAF, VHL, BNIP3, BIRC5, BECN1
27	phosphatidylinositol-mediated signaling	GO:048015	10.8	PIK3CB, PIK3CA, PCNA, MTOR, CDKN1B, GSK3B
28	response to organic cyclic compound	GO:014070	10.8	SFRP1, MSH2, JUN, CDKN1A, MET, IL1A
29	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.8	KITLG, VTN, VEGFA, MTOR, CD36, CD80
30	positive regulation of protein kinase B signaling cascade	GO:051897	10.7	PIK3CG, CHI3L1, MTDH, MTOR, ANGPT1, IGF1
31	negative regulation of apoptotic process	GO:043066	10.6	PIK3CG, SFRP1, SERPINE1, BRAF, VEGFA, MYC
32	response to drug	GO:042493	10.5	SFRP1, SFRP2, SEMA3C, MYC, BCL2, LGALS1
33	positive regulation of apoptotic process	GO:043065	10.5	SFRP1, SFRP2, KCNMA1, BAX, MMP9, IL1B
34	blood coagulation	GO:007596	10.4	PIK3CB, PIK3CA, PIK3CG, VWF, SERPINE1, BSG
35	positive regulation of DNA replication	GO:045740	10.4	KITLG, JUN, CDC42, MET, IL3, IGF1R
36	positive regulation of cell proliferation	GO:008284	10.4	KIT, SFRP1, SFRP2, VEGFA, MYC, BIRC5
37	aging	GO:007568	10.3	FURIN, JUN, IL1B, FAS, CCL2, F3
38	positive regulation of MAP kinase activity	GO:043406	10.2	PIK3CG, KITLG, VEGFA, FLT1, FGFR1, ERBB2
39	negative regulation of cell proliferation	GO:008285	10.1	SFRP1, SFRP2, VHL, RAF1, BECN1, JUN
40	response to mechanical stimulus	GO:009612	10.0	CHI3L1, JUN, MMP9, ANGPT2, CCL2, F3
41	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.9	PIK3CA, SFRP2, BRAF, VEGFA, RAF1, BCL2
42	platelet degranulation	GO:002576	9.9	VWF, SERPINE1, VEGFA, CD36, ITGB3, FN1
43	activation of MAPK activity	GO:000187	9.9	PIK3CB, KIT, FPR1, FGF2, MET, IL1B
44	transforming growth factor beta receptor signaling pathway	GO:007179	9.7	SERPINE1, MYC, BMPR1A, PARP1, FURIN, JUN
45	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.6	VHL, MYC, ZFP36, PARP1, CIITA, MTDH
46	positive regulation of transcription, DNA-dependent	GO:045893	9.3	SFRP1, RB1, VHL, MYC, BMP7, BMPR1A
47	platelet activation	GO:030168	9.0	PIK3CB, PIK3CA, PIK3CG, VWF, SERPINE1, VEGFA
48	positive regulation of smooth muscle cell proliferation	GO:048661	8.9	JUN, FLT1, IL13, IL6, IGF1, TNF
49	inflammatory response	GO:006954	8.9	PIK3CG, KIT, BMP6, BMPR1B, RAC1, CHI3L1
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.3	SFRP2, RB1, SERPINE1, VEGFA, MYC, BMP6

Molecular functions related to malignant glioma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	17.0	PECAM1, EFEMP1, EFNA1, ADM, HDAC1, HDAC9
2	ATP binding	GO:005524	12.9	KIT, BRAF, BMPR1A, BMPR1B, RAF1, CLCN3
3	receptor activity	GO:004872	11.7	TNFRSF10B, TNFRSF11B, TNFRSF6B, NRP2, PLAUR, PLXNC1
4	protein kinase binding	GO:019901	11.6	TP53, TP73, PTEN, PTK2, SMAD3, RPS6
5	protein heterodimerization activity	GO:046982	11.4	PDGFB, PDGFA, SRI, TP53, ERBB2, EGFR
6	identical protein binding	GO:042802	11.2	TP53, ERBB2, AKT1, CASP8, IGF1R, FAS
7	enzyme binding	GO:019899	10.9	HIF1A, H2AFX, EGFR, NFKBIA, PLAUR, TOP2A
8	receptor binding	GO:005102	10.9	NOS2, PLXNC1, NTF3, SRI, TNFSF10, TNC
9	collagen binding	GO:005518	10.8	SMAD7, PDGFA, PDGFB, DCN, CSPG4, SMAD4
10	protein homodimerization activity	GO:042803	10.3	PDGFRA, PDGFB, PDGFA, NOS2, SMAD4, SMAD3
11	transcription factor binding	GO:008134	10.3	DNMT1, HIF1A, NFKBIA, NFIA, SMAD3, STAT3
12	growth factor activity	GO:008083	9.4	IGF1, NUDT6, CSF2, CSF3, EFEMP1, HGF
13	cytokine activity	GO:005125	9.0	KITLG, VEGFA, BMP6, BMP7, MIF, IFNB1