MCID: MLG054
MIFTS: 58

Malignant Histiocytosis malady

Summaries for Malignant Histiocytosis

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64Wikipedia, 33MalaCards
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Wikipedia:64 Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary... more...

MalaCards: Malignant Histiocytosis, also known as histiocytic medullary reticulosis, is related to acute leukemia and anaplastic large cell lymphoma. An important gene associated with Malignant Histiocytosis is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are TGF-Beta Pathway and Transcription NF-kB signaling pathway. The compounds gm-csf and p003 have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Malignant Histiocytosis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 22GTR, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
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Aliases & Descriptions:

malignant histiocytosis 8 10 45 61
histiocytic medullary reticulosis 8 22 61
malignant midline reticulosis 8
malignant reticulosis 8
stewart's granuloma 8


External Ids:

Disease Ontology8 DOID:8580
MeSH35 D054747
ICD9CM27 202.3
NCIt40 C7202

Related Diseases for Malignant Histiocytosis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the histiocytosis family:

malignant histiocytosis histiocytosis with joint contractures and sensorineural deafness

Diseases related to Malignant Histiocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1acute leukemia30.7CSF1R, CSF1, PTPRC, MYB, TFRC
2anaplastic large cell lymphoma30.3PTPRC, TNFRSF8, CSF1R
3t-cell leukemia30.3TNFRSF8, MYB, LTA, IL1A, PTPRC, TFRC
4arthritis30.2IL1A, IL1B, SERPINA1
5systemic lupus erythematosus30.2PTPRC, F2, CRP, LTA, IL1R1
6polymyositis30.0IL1A
7crohn's disease30.0CRP
8acute myelomonocytic leukemia30.0CSF1, CSF1R
9acquired immunodeficiency syndrome30.0IL1B
10letterer-siwe disease30.0CD68, CSF1
11uveitis30.0IL1R1, IL1A, LTA
12vasculitis29.9F2, CRP, SERPINA1
13thrombocytopenia29.9CSF1, MYB, IL1R1, F2, IL1A
14omenn syndrome10.3
15splenic infarction10.3
16cytomegalic inclusion disease10.3
17virus associated hemophagocytic syndrome10.3
18lethal midline granuloma10.3
19malignant germ cell tumor10.3
20acute t cell leukemia10.2
21acute lymphocytic leukemia10.2
22lymphoblastic lymphoma10.2
23adult respiratory distress syndrome10.1
24fibrous histiocytoma10.1
25visceral leishmaniasis10.1
26myeloid sarcoma10.1
27adult syndrome10.1
28chronic active epstein-barr virus infection10.1
29splenomegaly10.1
30teratoma10.1
31histiocytic sarcoma10.1
32parapsoriasis10.1
33b-cell lymphomas10.1
34lymphomatoid granulomatosis10.1
35lymphoid leukemia10.0
36rubella10.0
37cystadenoma10.0
38malignant histiocytic disease10.0
39polycythemia vera10.0
40langerhans cell sarcoma10.0
41acute monocytic leukemia10.0
42klinefelter's syndrome10.0
43hemophagocytic lymphohistiocytosis10.0
44kwashiorkor10.0
45sickle cell anemia10.0
46peliosis hepatis10.0
47natural killer cell leukemia10.0
48interdigitating dendritic cell sarcoma10.0
49bone lymphoma10.0
50intussusception10.0

Graphical network of the top 20 diseases related to Malignant Histiocytosis:



Diseases related to malignant histiocytosis

Clinical Features for Malignant Histiocytosis

Drugs & Therapeutics for Malignant Histiocytosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Malignant Histiocytosis

Drug clinical trials:

Search ClinicalTrials for Malignant Histiocytosis

Search NIH Clinical Center for Malignant Histiocytosis

Search CenterWatch for Malignant Histiocytosis

Genetic Tests for Malignant Histiocytosis

Sources:
22GTR
See all sources

Genetic tests related to Malignant Histiocytosis:

id Genetic test Affiliating Genes
1 Histiocytic Medullary Reticulosis22

Anatomical Context for Malignant Histiocytosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Malignant Histiocytosis:

33
Skin, Liver, Spinal cord, Brain, Lymph node, Lung, Spleen, Bone marrow, Small intestine, Colon, Pancreas, Thyroid, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells

Animal Models for Malignant Histiocytosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Malignant Histiocytosis

Sources:
51PubMed
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Articles related to Malignant Histiocytosis:

(show top 50)    (show all 364)
idTitleAuthorsYear
1
Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark. (20154310)
2010
2
Malignant histiocytosis. (11138619)
2001
3
A case of malignant histiocytosis associated with skin involvement mimicking kwashiorkor. (11841654)
2001
4
Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis. (9766624)
1998
5
Epstein-Barr virus (EBV)-induced CD30+ natural killer cell-type malignancy resembling malignant histiocytosis: malignant transformation in chronic active EBV infection associating hypogammaglobulinemia. (9211526)
1997
6
True malignant histiocytosis developed during chemotherapy for mediastinal immature teratoma. (8892599)
1996
7
Malignant histiocytosis in three Bernese mountain dogs. (8735262)
1996
8
Analysis of the Epstein-Barr viral genome in so-called malignant histiocytosis syndrome. (8809882)
1996
9
Etoposide-based combination chemotherapy in malignant histiocytosis. (7760434)
1994
10
Robb-Smith type malignant histiocytosis associated with a mediastinal germ cell tumor. (7830338)
1994
11
Neurological manifestations in patients with malignant histiocytosis. (7706964)
1994
12
Malignant histiocytosis with multiple skin lesions in a dog. (8117808)
1993
13
Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)
1992
14
A case of B-cell lymphoma with clinical and histological features of malignant histiocytosis]. (1301324)
1992
15
Uveitis, a presenting symptom of malignant histiocytosis. (1427434)
1992
16
Phenytoin-induced hemocytophagic histiocytosis indistinguishable from malignant histiocytosis. (2035091)
1991
17
T-lymphoblastic lymphoma terminating as malignant histiocytosis with rearrangement of immunoglobulin heavy chain gene. (1825682)
1991
18
Malignant histiocytosis presenting as erythroderma. (2139870)
1990
19
DEL cell line: a "malignant histiocytosis" CD30+ t(5;6)(q35;p21) cell line. (2307542)
1990
20
A case of malignant histiocytosis successfully treated with combination interferon and etoposide therapy. (2126576)
1990
21
Expression of natural killer (NK) antigens in malignant histiocytosis and a subset of acute myelomonocytic leukaemias. (2627603)
1989
22
Lack of involvement of the c-fms and N-myc genes by chromosomal translocation t(2;5)(p23;q35) common to malignancies with features of so-called malignant histiocytosis. (2525056)
1989
23
Hyperferritinaemia as a significant indicator suggesting malignant histiocytosis. (2765413)
1989
24
Maturation of Howell-Jolly bodies observed in a case of malignant histiocytosis. (3421016)
1988
25
Sinusoidal hematolymphoid malignancy ("malignant histiocytosis") presenting as atypical sinusoidal proliferation. A study of nine cases. (3756790)
1986
26
Malignant histiocytosis: report of three cases. (3831202)
1985
27
Cytophagic histiocytic panniculitis. A variant of malignant histiocytosis. (3995472)
1985
28
Transformation of mononuclear phagocytes in vivo and malignant histiocytosis caused by a novel murine spleen focus-forming virus. (3873013)
1985
29
Erythema annulare centrifugum and malignant histiocytosis--report of a case. (6499278)
1984
30
Malignant histiocytosis--a clinicopathologic study of 5 cases. (6549118)
1984
31
Malignant histiocytosis and related tumors. A clinicopathologic study of 42 cases using cytological, histochemical and ultrastructural parameters. (6329939)
1984
32
Malignant histiocytosis in a patient with sickle cell anemia: CT findings. (6886145)
1983
33
Malignant histiocytosis and Letterer-Siwe disease. Neoplasms of T-zone histiocyte with S100 protein. (6687444)
1983
34
Malignant histiocytosis. Case report and review. (6687475)
1983
35
Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease. (6840619)
1983
36
Tumor cell line characterization of a malignant histiocytosis transplanted into nude mice. (7179735)
1982
37
Malignant histiocytosis presenting as lethal midline granuloma: immunohistological study. (6752361)
1982
38
Respiratory failure in malignant histiocytosis. (7305121)
1981
39
Blood and bone marrow findings in malignant histiocytosis. (6797879)
1981
40
T gamma cells: a missing link between malignant histiocytosis and T cell leukemia-lymphoma? (6975747)
1981
41
Acute lymphocytic leukaemia terminating in malignant histiocytosis. A case report and literature review. (6929112)
1980
42
Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. (225008)
1979
43
Cytomorphologic and cytochemical aspects of malignant histiocytosis with spindle-cell differentiation. A case report. (294074)
1979
44
Muramidase, an immunohistochemical marker of malignant histiocytosis. (381160)
1979
45
Malignant histiocytosis: a cytochemical and electron microscopic study of an unusual case. (509393)
1979
46
Serum lysozyme levels in malignant histiocytosis of the intestine. (533696)
1979
47
Malignant histiocytosis: a histological and ultrastructural study of lymph nodes in six cases. (721076)
1978
48
Effective combination chemotherapy of adult malignant histiocytosis (histiocytic medullary reticulosis). (625260)
1978
49
Malignant histiocytosis of the intestine. Its relationship to malabsorption and ulcerative jejunitis. (730148)
1978
50
Malignant histiocytosis: report of a case and response to radiation therapy. (5685732)
1968

Genetic Variations for Malignant Histiocytosis

Expression for genes affiliated with Malignant Histiocytosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malignant Histiocytosis

Search GEO for disease gene expression data for Malignant Histiocytosis.

Pathways for genes affiliated with Malignant Histiocytosis

Sources:
52QIAGEN, 12EMD Millipore, 54Reactome, 30KEGG, 38NCBI BioSystems Database, 60Tocris Bioscience
See all sources

Pathways related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6CSF1R, LTA, F2
29.5LTA, IL1A, IL1R1
39.4IL1A, IL1B
49.4CSF1, IL1B, LTA
59.3LTA, IL1R1, IL1B
69.1IL1B, IL1A, LTA
7
Hide members
9.1IL1A, IL1R1, IL1B
8
Hide members
9.1IL1A, IL1R1, IL1B
9
Hide members
9.1IL1B, IL1A, IL1R1
109.1IL1A, IL1B, IL1R1
11
Hide members
9.1IL1A, IL1B, IL1R1
12
Immune response Bacterial infections in normal airways
Hide members
9.1IL1B, IL1A, IL1R1
13
Hide members
9.1IL1B, IL1R1, IL1A
149.1CSF1, IL1B, CD68
15
Hide members
8.8LTA, IL1R1, IL1A, IL1B
16
Hide members
8.8IL1A, LTA, IL1R1, IL1B
17
Hide members
8.8IL1A, CSF1, TNFRSF8, CSF1R
188.7SERPINA3, F2, IL1B, CRP
19
Hide members
8.7IL1B, IL1A, IL1R1, PTPRC
208.7IL1B, CSF1R, CSF1, IL1A, IL1R1
218.4CSF1R, IL1B, IL1A, IL1R1, TFRC, CSF1
22
Hide members
8.3PTPRC, IL1R1, LTA, TNFRSF8, CSF1, CSF1R
23
Hide members
8.0TNFRSF8, LTA, IL1A, IL1B, IL1R1
24
Hide members
7.6TNFRSF8, CSF1R, LTA, IL1A, IL1B, IL1R1
25
Hide members
7.6CSF1R, IL1B, CSF1, TNFRSF8, LTA, IL1R1

Compounds for genes affiliated with Malignant Histiocytosis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.6CSF1R
2p0034510.6CSF1
3indomethacin45 60 29 1113.3CSF1, IL1R1
4tenidap45 2911.2IL1R1, IL1A
5pentoxifylline45 1111.1IL1R1, LTA
6cycloheximide4510.1LTA, CSF1R, TFRC
7acetylcholine45 50 29 11 2414.0TFRC, LTA, SERPINA3
8h2o2459.7PTPRC, IL1R1, LTA, MYB
9methylcellulose459.6CSF1, TFRC, MYB, IL1A
10fmlp459.6PTPRC, SERPINA3, CSF1, IL1A
11dexamethasone45 50 29 1112.5CSF1R, PTPRC, MYB, LTA, IL1R1
12dmso459.3PTPRC, CSF1R, MYB, TFRC, CSF1
13vitamin a45 11 2411.3SERPINA3, SERPINA1, IL1A, TFRC
14anakinra45 1110.3CRP, IL1R1, IL1B
15git 27609.2IL1R1, IL1B, IL1A
164-ipp609.2IL1B, IL1A, IL1R1
17iron45 2410.1SERPINA3, SERPINA1, IL1R1, TFRC, MYB
18methionine459.1SERPINA3, IL1R1, MYB, CSF1R, PTPRC, SERPINA1
19infliximab45 50 1111.0IL1R1, IL1B, CRP, LTA
20il 10459.0IL1B, IL1R1, LTA, IL1A, CSF1
21ionomycin459.0PTPRC, CSF1, LTA, IL1A, SERPINA3, TFRC
22etanercept45 50 1111.0LTA, CRP, IL1R1, CSF1, IL1B
23serine458.9CSF1, CSF1R, UCHL1, IL1A, IL1R1, SERPINA3
24polyethylene glycol458.9TFRC, CRP, IL1R1, F2, IL1A
25heparin45 29 11 2411.9IL1R1, CSF1, PTPRC, SERPINA1, IL1A, SERPINA3
26sulfasalazine45 29 50 1111.8IL1R1, CRP, CSF1, IL1A, IL1B
27rapamycin458.8TFRC, CRP, CSF1, IL1R1, IL1A, MYB
28herbimycin a45 609.7IL1A, IL1B, LTA, TFRC, PTPRC
29ascorbic acid45 249.7IL1R1, SERPINA1, CRP, CSF1, IL1A, TFRC
30calcitriol45 60 11 2411.6IL1A, F2, IL1B, LTA, TFRC, CSF1
31cyclosporin a45 29 6010.5PTPRC, F2, IL1R1, LTA, TNFRSF8, MYB
32ivig458.5IL1B, IL1R1, CRP, LTA, IL1A, CSF1
33acth458.5IL1A, IL1R1, SERPINA1, IL1B, PTPRC
3412-o-tetradecanoylphorbol 13-acetate458.5IL1R1, IL1A, PTPRC, LTA, UCHL1, MYB
35creatinine458.5PDLIM3, F2, CRP, IL1A, SERPINA1, SERPINA3
36actinomycin d458.5TFRC, LTA, IL1R1, IL1A, IL1B, MYB
37lactate458.5CRP, IL1R1, LTA, CSF1, TFRC, F2
38hyaluronic acid45 249.5IL1A, PTPRC, F2, LTA, IL1R1, IL1B
39aspirin45 50 29 2411.3F2, IL1B, IL1R1, CRP, CSF1
40cysteine458.3PTPRC, SERPINA1, MYB, SERPINA3, IL1R1, UCHL1
41progesterone45 60 29 11 2412.3PTPRC, IL1R1, LTA, MYB, CSF1, CSF1R
42neopterin458.2TFRC, IL1B, IL1A, IL1R1, CRP, CSF1
43methotrexate45 50 1110.2IL1R1, F2, SERPINA3, IL1B, CRP
44n acetylcysteine458.2F2, PTPRC, IL1R1, CRP, TFRC, CSF1
45retinoic acid45 249.1IL1A, IL1R1, LTA, MYB, TFRC, CSF1
46vegf457.8IL1A, IL1B, LTA, MYB, IL1R1, TFRC
47thymidine45 248.6IL1R1, IL1B, SERPINA1, MYB, TFRC, IL1A
48tyrosine457.4TNFRSF8, MYB, IL1R1, CSF1R, LTA, TFRC
49paraffin457.3TNFRSF8, CD68, SERPINA1, SERPINA3, PTPRC, LTA
50lipid457.1IL1R1, LTA, CD68, SERPINA3, SERPINA1, PTPRC

GO Terms for genes affiliated with Malignant Histiocytosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.3SERPINA3, CSF1, CRP, LTA, IL1A, IL1B
2extracellular regionGO:0055767.1TFRC, CRP, IL1R1, IL1A, IL1B, F2
3plasma membraneGO:0058866.5CSF1R, CSF1, TNFRSF8, TFRC, CRP, CD68

Biological processes related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1osteoclast differentiationGO:0303169.9TFRC, CSF1, CSF1R
2macrophage differentiationGO:0302259.7CSF1, CSF1R
3response to lead ionGO:0102889.7SERPINA1, CRP
4fever generationGO:0016609.5IL1A, IL1B
5positive regulation of interleukin-2 biosynthetic processGO:0450869.3IL1A, IL1B
6positive regulation of protein phosphorylationGO:0019349.3F2, IL1B, CSF1R
7cell proliferationGO:0082839.3IL1A, CSF1, CSF1R, UCHL1
8acute-phase responseGO:0069539.2SERPINA3, SERPINA1, F2, CRP
9inflammatory responseGO:0069548.4CSF1R, CSF1, CRP, IL1A, IL1B, SERPINA3

Molecular functions related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.4IL1B, IL1A
2cytokine activityGO:0051258.6IL1B, IL1A, LTA, CSF1

Products for genes affiliated with Malignant Histiocytosis

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Sources for Malignant Histiocytosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet