MCID: MLG054
MIFTS: 60

Malignant Histiocytosis malady

Summaries for Malignant Histiocytosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary... more...

MalaCards: Malignant Histiocytosis, also known as histiocytic medullary reticulosis, is related to histiocytosis and leukemia. An important gene associated with Malignant Histiocytosis is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are TGF-Beta Pathway and Transcription NF-kB signaling pathway. The compounds gm-csf and p003 have been mentioned in the context of this disorder. Affiliated tissues include spleen, lymph node and liver, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Malignant Histiocytosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 22GTR, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

malignant histiocytosis 8 10 44 60
histiocytic medullary reticulosis 8 22 60
malignant midline reticulosis 8
malignant reticulosis 8
stewart's granuloma 8


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Disease Ontology8 DOID:8580
MeSH34 D054747
ICD9CM27 202.3
NCIt39 C7202

Related Diseases for Malignant Histiocytosis

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17GeneCards, 18GeneDecks
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Diseases in the Histiocytosis family:

malignant histiocytosis

Diseases related to Malignant Histiocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis31.8CD68
2leukemia30.8CSF1R, CSF1, TFRC, MYB, LTA, IL1R1
3acute leukemia30.6PTPRC, MYB, TFRC, CSF1, CSF1R
4mediastinitis30.4CRP
5sarcoma30.4CSF1R, CSF1, IL1R1, PTPRC
6anaplastic large cell lymphoma30.3PTPRC, TNFRSF8, CSF1R
7hepatitis30.3SERPINA1, F2, LTA, TFRC
8t-cell leukemia30.2TNFRSF8, TFRC, MYB, LTA, IL1A, PTPRC
9lupus erythematosus30.1F2
10malaria30.1TFRC, SERPINA3
11chronic lymphocytic leukemia30.1PTPRC, LTA, MYB, TFRC
12meningitis30.1IL1B, CRP
13hodgkin's lymphoma30.1CSF1R, TNFRSF8, LTA, CD68, PTPRC
14arthritis30.1IL1A, IL1B, SERPINA1
15systemic lupus erythematosus30.1PTPRC, F2, IL1R1, LTA, CRP
16rheumatoid arthritis30.1TNFRSF8, CSF1, TFRC, CRP, MYB, SERPINA3
17polycythemia29.9TFRC
18crohn's disease29.9CRP
19disseminated intravascular coagulation29.9F2
20acquired immunodeficiency syndrome29.9IL1B
21letterer-siwe disease29.9CSF1, CD68
22uveitis29.9LTA, IL1R1, IL1A
23vasculitis29.9CRP, F2, SERPINA1
24monocytic leukemia29.9CSF1, IL1R1, IL1B
25thrombocytopenia29.9CSF1, MYB, IL1R1, IL1A, F2
26myeloid leukemia29.9CSF1R, CSF1, TFRC, MYB, LTA, PTPRC
27respiratory failure29.9SERPINA1, IL1B, CRP
28pneumonia29.9SERPINA1, IL1B, CRP
29omenn syndrome10.3
30splenic infarction10.3
31lymphopenia10.3
32virus associated hemophagocytic syndrome10.3
33lethal midline granuloma10.3
34hepatitis a10.2
35acute lymphocytic leukemia10.2
36eosinophilia10.2
37leishmaniasis10.2
38malignant histiocytic disease10.1
39adult respiratory distress syndrome10.1
40fibrous histiocytoma10.1
41visceral leishmaniasis10.1
42acute t cell leukemia10.1
43myeloid sarcoma10.1
44adult syndrome10.1
45histiocytoma10.1
46intestinal disease10.1
47malignant teratoma10.1
48panniculitis10.1
49parapsoriasis10.1
50dementia10.0SERPINA3

Graphical network of the top 20 diseases related to Malignant Histiocytosis:



Diseases related to malignant histiocytosis

Clinical Features for Malignant Histiocytosis

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Drugs & Therapeutics for Malignant Histiocytosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Malignant Histiocytosis

Drug clinical trials:

Search ClinicalTrials for Malignant Histiocytosis

Search NIH Clinical Center for Malignant Histiocytosis

Search CenterWatch for Malignant Histiocytosis

Genetic Tests for Malignant Histiocytosis

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22GTR
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Genetic tests related to Malignant Histiocytosis:

id Genetic test Affiliating Genes
1 Histiocytic Medullary Reticulosis22

Anatomical Context for Malignant Histiocytosis

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32MalaCards
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MalaCards organs/tissues related to Malignant Histiocytosis:

32
Spleen, Lymph node, Liver, Lung, Bone marrow, Bone, T cells, Skin, Brain, B cells, Monocytes, Myeloid, Small intestine, Thyroid, Pancreas, Colon, Spinal cord

Animal Models for Malignant Histiocytosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Histiocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.5PTPRC, IL1R1, LTA
2MP:00107719.3CSF1R, MYB, IL1R1, F2
3MP:00053708.5UCHL1, CSF1, TFRC, MYB, LTA, IL1R1
4MP:00053908.4CSF1R, CSF1, LTA, CD68, IL1B, PTPRC
5MP:00053787.6UCHL1, CSF1R, CSF1, TFRC, MYB, LTA
6MP:00107687.0UCHL1, PDLIM3, CSF1R, CSF1, TFRC, MYB
7MP:00053856.8UCHL1, PDLIM3, CSF1, TFRC, CRP, MYB
8MP:00053766.7PDLIM3, CSF1R, CSF1, TFRC, CRP, LTA
9MP:00053976.3TFRC, TNFRSF8, CSF1, CSF1R, UCHL1, MYB
10MP:00053875.5PTPRC, CSF1R, CSF1, TNFRSF8, TFRC, CRP

Publications for Malignant Histiocytosis

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50PubMed
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Articles related to Malignant Histiocytosis:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Langerhans cell histiocytosis first presenting in the skin in adults: frequent association with a second haematological malignancy. (22835048)
2012
2
Systemic mastocytosis (SM) and associated malignant bone marrow histiocytosis - a hitherto undescribed form of SM-AHNMD. (21866466)
2011
3
Malignant histiocytosis with central nervous system involvement and hepatic mucinous cystadenoma in a single patient with review of the literature. (18067214)
2007
4
An Asian variant of intravascular lymphomatosis: an updated review of malignant histiocytosis-like B-cell lymphoma. (10342574)
1999
5
Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis. (9766624)
1998
6
Malignant histiocytosis-like B-cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature. (9401080)
1997
7
Analysis of the Epstein-Barr viral genome in so-called malignant histiocytosis syndrome. (8809882)
1996
8
Malignant histiocytosis in childhood: a disease in quest of new nosological criteria. (7603402)
1995
9
Colonic histiocytic neoplasm mimicking malignant histiocytosis and presenting as intussusception. (7774901)
1995
10
Malignant histiocytosis in the leukaemic stage: a new entity (M5c-AML) in the FAB classification? (8127155)
1994
11
Cytology of canine malignant histiocytosis. (12666013)
1994
12
Recurrent malignant histiocytosis with cerebrospinal involvement--case report. (7520547)
1994
13
Hyperferritinemia associated with malignant histiocytosis in a dog. (7829379)
1994
14
Malignant histiocytosis associated with autoimmune thrombocytopenia. (8296797)
1994
15
Malignant histiocytosis. A report of three cases. (1332645)
1992
16
Uveitis, a presenting symptom of malignant histiocytosis. (1427434)
1992
17
Cytokine levels in aggressive natural killer cell leukemia and malignant histiocytosis. (1911378)
1991
18
Unusual clinical presentation of malignant histiocytosis in a 70-year-old woman. (2066713)
1991
19
Clinicopathological diagnosis and treatment of malignant histiocytosis. (2207002)
1990
20
The malignant histiocytosis sarcoma virus, a recombinant of Harvey murine sarcoma virus and Friend mink cell focus-forming virus, has acquired myeloid transformation specificity by alterations in the long terminal repeat. (2152823)
1990
21
Hyperferritinaemia as a significant indicator suggesting malignant histiocytosis. (2765413)
1989
22
Malignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature. (3416066)
1988
23
Malignant histiocytosis. Clinicopathologic review of 18 cases with immunohistochemical study. (3267356)
1988
24
Abnormal serum phenylalanine-tyrosine ratio and hyperferritinemia in malignant histiocytosis. (3152976)
1988
25
Maturation of Howell-Jolly bodies observed in a case of malignant histiocytosis. (3421016)
1988
26
Prognostic evaluation of serum leucine aminopeptidase in malignancy of lymphoreticular and haemopoietic cell lines in children, with special reference to malignant histiocytosis of the intestine. (3385854)
1988
27
Immunophenotype analysis of malignant histiocytosis of the intestine. (3512610)
1986
28
Malignant histiocytosis in childhood. Clinical features and therapeutic results by combination chemotherapy. (3799930)
1986
29
Malignant histiocytosis (histiocytic sarcoma). A (the?) major cause of the 'midline granuloma syndrome'. (3515840)
1986
30
Malignant histiocytosis and related tumors. A clinicopathologic study of 42 cases using cytological, histochemical and ultrastructural parameters. (6329939)
1984
31
Malignant histiocytosis and ulcerative jejunitis of the small intestine. (6839654)
1983
32
Radiological findings in 23 pediatric cases of malignant histiocytosis (MH). (6840108)
1983
33
Malignant histiocytosis and encephalomyeloradiculopathy complicating coeliac disease. (6840619)
1983
34
Malignant histiocytosis: a clinico-pathological study of three autopsied cases. (6981720)
1982
35
Malignant histiocytosis presenting as lethal midline granuloma: immunohistological study. (6752361)
1982
36
Malignant histiocytosis --- a case report. (7332304)
1981
37
A cytochemical and immunohistochemical approach to malignant histiocytosis. (6167344)
1981
38
Sideroblastic anaemia in association with malignant histiocytosis. (7256212)
1981
39
Therapy of malignant histiocytosis. (7327431)
1981
40
Atypical malignant histiocytosis. Its appearance as a single meningeal tumor or as multiple skin tumors. (6894527)
1981
41
Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. (7379013)
1980
42
Malignant histiocytosis in children from the Eastern Mediterranean. (7453672)
1980
43
Malignant histiocytosis of the intestine. (467214)
1979
44
Muramidase, an immunohistochemical marker of malignant histiocytosis. (381160)
1979
45
Malignant histiocytosis: a cytochemical and electron microscopic study of an unusual case. (509393)
1979
46
Serum lysozyme levels in malignant histiocytosis of the intestine. (533696)
1979
47
Malignant histiocytosis. Histiocytic medullary reticulosis. (75657)
1978
48
Oncornavirus-like particles from cultured bone marrow cells preceding leukemia and malignant histiocytosis. (52158)
1975
49
Malignant histiocytosis (histiocytic medullary reticulosis). I. Clinicopatholigic study of 29 cases. (1167345)
1975
50
Malignant histiocytosis with eosinophilia. (4757932)
1973

Genetic Variations for Malignant Histiocytosis

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Expression for genes affiliated with Malignant Histiocytosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Histiocytosis

Search GEO for disease gene expression data for Malignant Histiocytosis.

Pathways for genes affiliated with Malignant Histiocytosis

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51QIAGEN, 12EMD Millipore, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 59Tocris Bioscience
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Pathways related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6CSF1R, LTA, F2
29.5IL1A, IL1R1, LTA
39.4IL1A, IL1B
49.4CSF1, LTA, IL1B
59.3LTA, IL1R1, IL1B
69.1IL1B, IL1A, LTA
7
Hide members
9.1IL1R1, IL1A, IL1B
8
Immune response Bacterial infections in normal airways
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9.1IL1B, IL1A, IL1R1
9
Hide members
9.1IL1B, IL1A, IL1R1
10
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9.1IL1R1, IL1A, IL1B
11
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9.1IL1R1, IL1A, IL1B
12
Hide members
9.1IL1B, IL1A, IL1R1
139.1IL1B, IL1A, IL1R1
149.1IL1B, CD68, CSF1
15
Hide members
8.8LTA, IL1R1, IL1A, IL1B
16
Hide members
8.8LTA, IL1R1, IL1A, IL1B
17
Hide members
8.8IL1A, TNFRSF8, CSF1, CSF1R
188.7CRP, IL1B, F2, SERPINA3
19
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8.7PTPRC, IL1B, IL1A, IL1R1
208.7CSF1R, CSF1, IL1R1, IL1A, IL1B
218.4IL1B, IL1A, IL1R1, TFRC, CSF1, CSF1R
22
Hide members
8.3CSF1R, CSF1, TNFRSF8, LTA, IL1R1, PTPRC
23
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8.0TNFRSF8, LTA, IL1R1, IL1A, IL1B
24
Hide members
7.6CSF1R, CSF1, TNFRSF8, LTA, IL1R1, IL1A
25
Hide members
7.6CSF1R, CSF1, TNFRSF8, LTA, IL1R1, IL1A

Compounds for genes affiliated with Malignant Histiocytosis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.6CSF1R
2p0034410.6CSF1
3indomethacin44 59 28 1113.3CSF1, IL1R1
4tenidap44 2811.2IL1R1, IL1A
5pentoxifylline44 1111.1IL1R1, LTA
6cycloheximide4410.1LTA, CSF1R, TFRC
7acetylcholine44 49 28 11 2414.0TFRC, LTA, SERPINA3
8h2o2449.7PTPRC, IL1R1, LTA, MYB
9methylcellulose449.6CSF1, TFRC, MYB, IL1A
10fmlp449.6PTPRC, SERPINA3, CSF1, IL1A
11dexamethasone44 49 28 1112.5CSF1R, PTPRC, MYB, LTA, IL1R1
12dmso449.3PTPRC, CSF1R, MYB, TFRC, CSF1
13vitamin a44 11 2411.3SERPINA3, SERPINA1, IL1A, TFRC
14anakinra44 1110.3CRP, IL1R1, IL1B
15git 27599.2IL1R1, IL1B, IL1A
164-ipp599.2IL1B, IL1A, IL1R1
17iron44 2410.1SERPINA3, SERPINA1, IL1R1, TFRC, MYB
18methionine449.1SERPINA3, IL1R1, MYB, CSF1R, PTPRC, SERPINA1
19infliximab44 49 1111.0IL1R1, IL1B, CRP, LTA
20il 10449.0IL1B, IL1R1, LTA, IL1A, CSF1
21ionomycin449.0PTPRC, CSF1, LTA, IL1A, SERPINA3, TFRC
22etanercept44 49 1111.0LTA, CRP, IL1R1, CSF1, IL1B
23serine448.9CSF1, CSF1R, UCHL1, IL1A, IL1R1, SERPINA3
24polyethylene glycol448.9TFRC, CRP, IL1R1, F2, IL1A
25heparin44 28 11 2411.9IL1R1, CSF1, PTPRC, SERPINA1, IL1A, SERPINA3
26sulfasalazine44 28 49 1111.8IL1R1, CRP, CSF1, IL1A, IL1B
27rapamycin448.8TFRC, CRP, CSF1, IL1R1, IL1A, MYB
28herbimycin a44 599.7IL1A, IL1B, LTA, TFRC, PTPRC
29ascorbic acid44 249.7IL1R1, SERPINA1, CRP, CSF1, IL1A, TFRC
30calcitriol44 59 11 2411.6IL1A, F2, IL1B, LTA, TFRC, CSF1
31cyclosporin a44 28 5910.5PTPRC, F2, IL1R1, LTA, TNFRSF8, MYB
32ivig448.5IL1B, IL1R1, CRP, LTA, IL1A, CSF1
33acth448.5IL1A, IL1R1, SERPINA1, IL1B, PTPRC
3412-o-tetradecanoylphorbol 13-acetate448.5IL1R1, IL1A, PTPRC, LTA, UCHL1, MYB
35creatinine448.5PDLIM3, F2, CRP, IL1A, SERPINA1, SERPINA3
36actinomycin d448.5TFRC, LTA, IL1R1, IL1A, IL1B, MYB
37lactate448.5CRP, IL1R1, LTA, CSF1, TFRC, F2
38hyaluronic acid44 249.5IL1A, PTPRC, F2, LTA, IL1R1, IL1B
39aspirin44 49 28 2411.3F2, IL1B, IL1R1, CRP, CSF1
40cysteine448.3PTPRC, SERPINA1, MYB, SERPINA3, IL1R1, UCHL1
41progesterone44 59 28 11 2412.3PTPRC, IL1R1, LTA, MYB, CSF1, CSF1R
42neopterin448.2TFRC, IL1B, IL1A, IL1R1, CRP, CSF1
43methotrexate44 49 1110.2IL1R1, F2, SERPINA3, IL1B, CRP
44n acetylcysteine448.2F2, PTPRC, IL1R1, CRP, TFRC, CSF1
45retinoic acid44 249.1IL1A, IL1R1, LTA, MYB, TFRC, CSF1
46vegf447.8IL1A, IL1B, LTA, MYB, IL1R1, TFRC
47thymidine44 248.6IL1R1, IL1B, SERPINA1, MYB, TFRC, IL1A
48tyrosine447.4TNFRSF8, MYB, IL1R1, CSF1R, LTA, TFRC
49paraffin447.3TNFRSF8, CD68, SERPINA1, SERPINA3, PTPRC, LTA
50lipid447.1IL1R1, LTA, CD68, SERPINA3, SERPINA1, PTPRC

GO Terms for genes affiliated with Malignant Histiocytosis

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16Gene Ontology
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Cellular components related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.3SERPINA3, CSF1, CRP, LTA, IL1A, IL1B
2extracellular regionGO:0055767.1TFRC, CRP, IL1R1, IL1A, IL1B, F2
3plasma membraneGO:0058866.5CSF1R, CSF1, TNFRSF8, TFRC, CRP, CD68

Biological processes related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1osteoclast differentiationGO:0303169.9TFRC, CSF1, CSF1R
2macrophage differentiationGO:0302259.7CSF1, CSF1R
3response to lead ionGO:0102889.7SERPINA1, CRP
4fever generationGO:0016609.5IL1A, IL1B
5positive regulation of interleukin-2 biosynthetic processGO:0450869.3IL1A, IL1B
6positive regulation of protein phosphorylationGO:0019349.3F2, IL1B, CSF1R
7cell proliferationGO:0082839.3IL1A, CSF1, CSF1R, UCHL1
8acute-phase responseGO:0069539.2SERPINA3, SERPINA1, F2, CRP
9inflammatory responseGO:0069548.4CSF1R, CSF1, CRP, IL1A, IL1B, SERPINA3

Molecular functions related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.4IL1B, IL1A
2cytokine activityGO:0051258.6IL1B, IL1A, LTA, CSF1

Products for genes affiliated with Malignant Histiocytosis

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Sources for Malignant Histiocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet