Malignant Histiocytosis malady

Wikipedia: Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary...⁴⁴ more...

MalaCards: Malignant Histiocytosis, also known as histiocytic medullary reticulosis (disorder), is related to histiocytosis and b-cell lymphomas. An important gene associated with Malignant Histiocytosis is MYB (v-myb myeloblastosis viral oncogene homolog (avian)), and among its related pathways are IL-6 Pathway and Tec Kinases Signaling. The compounds ionomycin and polyethylene glycol have been mentioned in the context of this disorder. Affiliated tissues include lymph node, spleen and liver, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Aliases & Descriptions:

malignant histiocytosis 6 8 32 43 histiocytic medullary reticulosis (disorder) 43 histiocytic medullary reticulosis 6

malignant midline reticulosis 6 malignant reticulosis 6 stewart's granuloma 6

Diseases related to malignant histiocytosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 371)

id	Related Disease	Score	Top Affiliating Genes
1	histiocytosis	25.3	SERPINA1, SERPINA3, MYB, UCHL1, IL1A, IL1B
2	b-cell lymphomas	25.2	MYB, IL1A, IL1B, TNFRSF8, CRP, PDLIM3
3	hepatitis	22.3	SERPINA1, SERPINA3, MYB, IL1A, IL1B, IL1R1
4	acute myelomonocytic leukemia	13.4	CSF1, CSF1R
5	systemic onset juvenile idiopathic arthritis	13.4	SERPINA3, IL1R1
6	giant cell tumor	13.3	SERPINA3, TNFRSF8, CSF1
7	alpha-1-antichymotrypsin deficiency	13.2	SERPINA1, SERPINA3
8	cinca syndrome	13.1	IL1B, IL1R1
9	cutaneous t cell lymphoma	13.1	MYB, TNFRSF8, TFRC
10	myelomonocytic leukemia	13.1	MYB, CSF1, CSF1R
11	familial cold autoinflammatory syndrome	13.1	IL1B, IL1R1
12	vulvar vestibulitis syndrome	13.1	IL1B, IL1R1
13	idiopathic myopathy	13.1	IL1A, IL1R1
14	secondary syphilis	13.0	PDLIM3, LTA, CSF1
15	psoriatic arthritis	13.0	IL1B, LTA
16	granular cell tumor	12.9	SERPINA1, SERPINA3, UCHL1
17	obstructive lung disease	12.9	SERPINA1, SERPINA3, LTA
18	leukemia/lymphoma, t-cell	12.9	TNFRSF8, TFRC, CSF1, CSF1R
19	post-transplant lymphoproliferative disease	12.9	IL1A, IL1R1, LTA
20	adult-onset still's disease	12.9	IL1R1, CRP, CSF1
21	letterer-siwe disease	12.9	IL1B, IL1R1, CSF1
22	stachybotrys chartarum	12.8	IL1A, IL1B, CSF1
23	somatoform disorder	12.8	IL1A, IL1B
24	viral meningitis	12.8	SERPINA1, CRP
25	cicatricial pemphigoid	12.8	IL1A, IL1B, CSF1
26	angiosarcoma	12.8	SERPINA3, CRP, CSF1
27	mastitis	12.8	IL1B, IL1R1, CSF1
28	leukemia/lymphoma	12.8	TNFRSF8, TFRC, CSF1, CSF1R
29	funisitis	12.8	IL1B, CRP
30	adult t-cell leukemia	12.7	IL1R1, TNFRSF8, LTA, CSF1
31	anterior uveitis	12.7	HNRNPH3, CRP, LTA
32	x-linked sideroblastic anemia	12.7	IL1B, CRP
33	rheumatoid arthritis	12.7	IL1R1, CRP, LTA
34	cerebral malaria	12.7	IL1A, IL1B, IL1R1
35	cardiac sarcoidosis	12.7	IL1A, IL1B, LTA
36	bacterial vaginosis	12.7	IL1A, IL1B, IL1R1
37	meningococcemia	12.7	IL1A, IL1B
38	myelodysplastic syndrome	12.7	IL1A, TFRC, CSF1, CSF1R
39	papilledema	12.7	IL1R1, F2
40	aphthous stomatitis	12.7	IL1A, IL1B, LTA
41	iga glomerulonephritis	12.7	SERPINA1, IL1R1, TFRC
42	monocytic leukemia	12.7	IL1B, IL1R1, CSF1, CSF1R
43	glucocorticoid resistance	12.7	IL1A, IL1B, IL1R1
44	vascular dementia	12.7	SERPINA3, IL1A, IL1B
45	schnitzler syndrome	12.7	IL1A, IL1R1, CRP
46	paget's disease of bone	12.7	IL1B, IL1R1, PDLIM3, CSF1
47	hepatic tuberculosis	12.7	SERPINA1, F2
48	infectious mononucleosis	12.6	IL1A, TNFRSF8, CRP
49	febrile seizures	12.6	IL1A, IL1B, IL1R1
50	pemphigus vulgaris	12.6	IL1A, IL1B, IL1R1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to malignant histiocytosis:

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MGI Mouse Phenotypes related to malignant histiocytosis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	9.8	MYB, IL1R1
2	hematopoietic system phenotype	MP:0005397	9.7	UCHL1, TFRC, CSF1R
3	skeleton phenotype	MP:0005390	9.6	CSF1R, CSF1, IL1R1
4	immune system phenotype	MP:0005387	8.8	CSF1R, TFRC, TNFRSF8, F2, MYB
5	integument phenotype	MP:0010771	7.8	CSF1R, CSF1, TFRC, F2, IL1R1, UCHL1
6	mortality/aging	MP:0010768	6.3	CSF1R, CSF1, TFRC, LTA, PDLIM3, F2
7	homeostasis/metabolism phenotype	MP:0005376	6.2	LTA, TFRC, CSF1, CSF1R, PDLIM3, CRP
8	cardiovascular system phenotype	MP:0005385	6.0	MYB, CSF1, TFRC, LTA, PDLIM3, CRP

Articles related to malignant histiocytosis:

id	Title	Authors	Year	Affiliating Genes
1	Malignant histiocytosis. Histologic, cytochemical, chromosomal, and molecular data with a nosologic discussion. (9561912)	Gogusev J.... Nezelof C.	1998	IL1R1
2	Hepatic manifestation of malignant histiocytosis: a case study. (9055006)	Chow W.C.... Tan P.	1996	F2
3	Regulation of TNF-alpha and IL-1 gene expression duri ng TPA-induced differentiation of 'Malignant histiocytosis' DEL cell line t(5;6) (q35:p21). (8615653)	Gogusev J.... Nezelof C.	1996	IL1B, IL1A
4	Modulation of c-myc, c-myb, c-fos, c-sis and c-fms proto-oncogene expression and of CSF-1 transcripts and protein by phorbol diester in human malignant histiocytosis DEL cell line with 5q 35 break point. (8352523)	Gogusev J.... Nezelof C.	1993	MYB, CSF1R, CSF1
5	A case of B-cell lymphoma with clinical and histological features of malignant histiocytosis (1301324)	Iwahashi T.... Yanagisawa N.	1992	CRP, PDLIM3
6	Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)	Nezelof C.... Terrier-Lacombe M.J.	1992	MYB, TFRC, CSF1R
7	Human malignant histiocytosis CD30+ DEL cell line differentiates into macrophage-like cells when treated with a phorbol diester. (1913689)	Gogusev J.... Nezelof C.	1991	LTA
8	Distribution of three proteinases in tumor cells of malignant histiocytosis (2279308)	Ji Y.Y.	1990	SERPINA3
9	Genotype markers and proto-oncogene analysis in the CD30-positive 'malignant histiocytosis' DEL cell line with t(5;6)(q35;p21). (2163988)	Gogusev J.... Nezelof C.	1990	MYB, CSF1R

Genes related to malignant histiocytosis according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	MYB	v-myb myeloblastosis viral oncogene homolog (avian)	11.0	Publications
2	CSF1R	colony stimulating factor 1 receptor	11.0	Publications
3	SERPINA3	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	11.0	Publications
4	TNFRSF8	tumor necrosis factor receptor superfamily, member 8	11.0
5	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
6	HNRNPH3	heterogeneous nuclear ribonucleoprotein H3 (2H9)	11.0
7	PDLIM3	PDZ and LIM domain 3	11.0	Publications
8	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	11.0
9	TFRC	transferrin receptor (p90, CD71)	11.0	Publications
10	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
11	IL1R1	interleukin 1 receptor, type I	11.0	Publications
12	IL1A	interleukin 1, alpha	11.0	Publications
13	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0
14	IL1B	interleukin 1, beta	11.0	Publications
15	F2	coagulation factor II (thrombin)	11.0	Publications
16	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Pathways related to malignant histiocytosis according to GeneDecks:

(show all 37)

id	Pathway	Score	Top Affiliating Genes
1	IL-6 Pathway36	10.5	CSF1
2	Tec Kinases Signaling36	10.3	TNFRSF8, CSF1R
3	RAR-Gamma-RXR-Alpha Degradation36	10.1	CSF1, LTA
4	Akt Signaling36	10.0	TNFRSF8, LTA, CSF1
5	Molecular Mechanisms of Cancer36	9.6	IL1R1, TNFRSF8, LTA, CSF1R
6	Transcription NF-kB signaling pathway10	9.5	IL1A, IL1R1, LTA
7	Transcription_NF-kB signaling pathway41	9.5	LTA, IL1R1, IL1A
8	Cytokine Network36	9.4	IL1A, IL1B, LTA
9	Type I diabetes mellitus20	9.3	IL1A, IL1B, LTA
10	Endothelin-1 Signaling Pathway36	9.3	CSF1R, CSF1, IL1B, IL1A
11	IL-1 Pathway36	9.3	IL1A, IL1B, IL1R1
12	HMGB1 Pathway36	9.3	IL1R1, IL1B, IL1A
13	Immune response IL-1 signaling pathway10	9.2	IL1R1, IL1B, IL1A
14	Immune response_IL-1 signaling pathway41	9.2	IL1A, IL1B, IL1R1
15	ERK Signaling36	9.2	IL1A, IL1B, CSF1R
16	MIF Mediated Glucocorticoid Regulation36	9.1	CSF1, LTA, IL1B, IL1A
17	MIF Regulation of Innate Immune Cells36	9.1	CSF1, LTA, IL1B, IL1A
18	all-trans-Retinoic Acid Signaling in Brain36	9.1	CSF1, LTA, IL1B, IL1A
19	PEDF Induced Signaling36	9.1	IL1A, IL1B, LTA, CSF1
20	TREM1 Pathway36	9.1	IL1A, IL1B, IL1R1
21	SUMO Pathway36	9.0	LTA, IL1R1, IL1B, IL1A
22	14-3-3 Induced Apoptosis36	9.0	LTA, IL1R1, IL1B, IL1A
23	TRAF Pathway36	9.0	IL1A, IL1B, IL1R1, LTA
24	Apoptosis20	8.9	IL1R1, IL1B, IL1A
25	NF-KappaB (p50-p65) Pathway36	8.9	IL1A, IL1B, IL1R1, LTA
26	Osteoclast differentiation20	8.9	CSF1R, CSF1, IL1R1, IL1B, IL1A
27	Rheumatoid arthritis20	8.8	IL1A, IL1B, CSF1
28	NF-KappaB Family Pathway36	8.8	LTA, IL1R1, IL1B, IL1A
29	PAK Pathway36	8.8	IL1A, IL1B, LTA, CSF1
30	Rho Family GTPases36	8.6	CSF1R, CSF1, LTA, IL1B, IL1A
31	Hematopoietic cell lineage20	8.6	IL1A, IL1B, IL1R1, TFRC, CSF1, CSF1R
32	MAPK Signaling36	8.5	IL1A, IL1B, IL1R1, LTA, CSF1R
33	STAT3 Pathway36	8.3	CSF1R, CSF1, LTA, TNFRSF8, IL1R1, IL1B
34	Cytokine-cytokine receptor interaction20	8.3	CSF1R, CSF1, LTA, TNFRSF8, IL1R1, IL1B
35	JAK-STAT Pathway36	8.3	CSF1R, F2, IL1R1, IL1B, IL1A
36	Antioxidant Action of Vitamin-C36	8.3	CSF1R, CSF1, LTA, TNFRSF8, IL1R1, IL1B
37	p38 Signaling36	8.3	CSF1R, CSF1, LTA, TNFRSF8, IL1R1, IL1B

Compounds related to malignant histiocytosis according to GeneDecks:

(show top 50)    (show all 99)

id	Compound	Score	Top Affiliating Genes
1	ionomycin32	10.5	SERPINA3
2	polyethylene glycol32	10.5	TFRC
3	progesterone32 42 9 18 9	14.2	SERPINA3, CSF1, MYB
4	pge232	10.0	IL1A, IL1R1
5	rapamycin32 42	10.9	MYB, IL1R1, CSF1
6	methylcellulose32	9.9	CSF1, IL1A, MYB
7	ivig32	9.8	CSF1, CRP, LTA
8	ascorbic acid32 18	10.6	IL1A, TFRC, IL1R1
9	hyaluronic acid32 18	10.6	F2, LTA
10	h2o232	9.5	SERPINA1, CSF1, TFRC, MYB
11	af 1219842	9.4	IL1A, IL1B, IL1R1
12	n acetylcysteine32	9.3	IL1R1, F2, CSF1
13	estrogen32	9.3	SERPINA1, SERPINA3, F2
14	amphotericin b32	9.3	IL1R1, CSF1, CRP
15	anakinra32 9 9	11.2	IL1B, CRP, IL1R1
16	gold sodium thiomalate32	9.2	IL1B, IL1A, IL1R1
17	cysteine32	9.1	MYB, UCHL1, TFRC, SERPINA3, SERPINA1
18	vitamin a32 9 18 9	12.1	TFRC, CRP, SERPINA3, SERPINA1
19	tenidap42 32	9.9	CRP, IL1R1, IL1A, IL1B
20	heparin32 9 18 9	11.9	F2, SERPINA3, SERPINA1
21	pentoxifylline32 9 9	10.9	IL1R1, IL1A, IL1B, LTA
22	infliximab32 9 9	10.9	LTA, CRP, IL1R1, IL1B
23	fmlp32	8.8	CSF1, LTA, IL1B, IL1A, SERPINA3
24	il 1032	8.8	IL1B, IL1R1, LTA, IL1A, CSF1
25	p00332	8.8	CSF1, LTA, CRP, IL1R1, SERPINA1
26	etanercept32 9 9	10.7	IL1R1, LTA, CSF1, CRP, IL1B
27	sulfasalazine32 9 9	10.6	IL1A, IL1B, IL1R1, CRP, CSF1
28	acetylcholine32 9 18 9	11.6	CRP, LTA, TFRC, CSF1, SERPINA3, IL1A
29	12-o-tetradecanoylphorbol 13-acetate32	8.6	MYB, LTA, UCHL1, IL1A, IL1R1, CSF1
30	rantes32	8.5	IL1A, IL1B, IL1R1, CSF1, LTA
31	iron32 18	9.4	IL1R1, SERPINA1, CRP, MYB, SERPINA3, TFRC
32	endotoxin32	8.4	LTA, CRP, IL1B, IL1A, IL1R1
33	indomethacin32 9 9	10.4	IL1A, CSF1, IL1R1, IL1B, TFRC, LTA
34	paraffin32	8.3	TFRC, LTA, TNFRSF8, CSF1R, SERPINA1, IL1R1
35	actinomycin d32	8.2	LTA, MYB, IL1A, IL1B, TFRC, CSF1
36	methotrexate32 34 42 9 9	12.1	F2, SERPINA3, CRP, IL1B, IL1R1
37	calcitriol32 42 9 18 9	12.0	LTA, CSF1, TFRC, F2, IL1B, IL1A
38	cyclosporin a32 42	9.0	TNFRSF8, IL1R1, IL1A, MYB, LTA, TFRC
39	neopterin32	7.9	CSF1, IL1A, TFRC, LTA, IL1R1, IL1B
40	lactate32	7.9	LTA, CSF1, TFRC, CRP, F2, IL1R1
41	thymidine32 18	8.8	MYB, IL1A, TFRC, IL1R1, TNFRSF8, IL1B
42	dexamethasone32 42 34 9 9	11.7	IL1R1, IL1A, CSF1R, TFRC, CSF1, SERPINA3
43	retinoic acid32 42 18	9.7	LTA, IL1R1, IL1B, IL1A, CSF1, SERPINA3
44	lipid32	7.6	SERPINA3, SERPINA1, MYB, IL1R1, TNFRSF8, CRP
45	tyrosine32	7.6	SERPINA1, UCHL1, TFRC, IL1R1, TNFRSF8, LTA
46	cycloheximide32	7.5	TFRC, IL1R1, CRP, LTA, MYB, CSF1R
47	vegf32	7.4	LTA, IL1A, MYB, IL1B, IL1R1, CRP
48	alanine32	7.3	CSF1, IL1R1, MYB, TFRC, F2, SERPINA3
49	creatinine32	7.0	F2, PDLIM3, TFRC, CSF1, CRP, IL1R1
50	serine32	6.5	CSF1R, TFRC, TNFRSF8, F2, IL1R1, UCHL1

Cellular components related to malignant histiocytosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	6.6	SERPINA1, CSF1, LTA, CRP, F2, IL1B
2	extracellular region	GO:005576	6.5	CRP, F2, IL1R1, IL1B, IL1A, SERPINA3

Biological processes related to malignant histiocytosis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	macrophage differentiation	GO:030225	10.0	CSF1, CSF1R
2	fever generation	GO:001660	9.6	IL1A, IL1B
3	response to ozone	GO:010193	9.6	IL1B, IL1A
4	response to L-ascorbic acid	GO:033591	9.5	IL1A, IL1B
5	ovulation	GO:030728	9.5	IL1B, IL1R1
6	response to lead ion	GO:010288	9.3	SERPINA1, CRP
7	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.2	CSF1R, IL1B, IL1A
8	positive regulation of interleukin-2 biosynthetic process	GO:045086	9.1	IL1A, IL1B
9	positive regulation of protein phosphorylation	GO:001934	8.9	IL1B, F2, CSF1R
10	acute-phase response	GO:006953	8.6	SERPINA1, SERPINA3, F2, CRP
11	inflammatory response	GO:006954	8.4	CSF1R, CSF1, CRP, IL1B, IL1A, SERPINA3
12	response to hypoxia	GO:001666	8.2	LTA, CRP, IL1B, IL1A, SERPINA1

Molecular functions related to malignant histiocytosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-1 receptor binding	GO:005149	9.4	IL1A, IL1B
2	cytokine activity	GO:005125	8.5	IL1A, IL1B, LTA, CSF1