MCID: MLG054
MIFTS: 63

Malignant Histiocytosis malady

Immune diseases, Rare diseases categories

Summaries for Malignant Histiocytosis

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary... more...

MalaCards: Malignant Histiocytosis, also known as histiocytic medullary reticulosis, is related to histiocytosis and leukemia. An important gene associated with Malignant Histiocytosis is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are TRAF Pathway and Signaling events mediated by TCPTP. The compounds methylcellulose and 4-ipp have been mentioned in the context of this disorder. Affiliated tissues include spleen, lymph node and liver, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Malignant Histiocytosis

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 23GTR, 59SNOMED-CT, 41NCIt, 28ICD9CM, 36MeSH
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


Aliases & Descriptions:

malignant histiocytosis 9 11 46 63
histiocytic medullary reticulosis 9 23 63
malignant midline reticulosis 9
malignant reticulosis 9
stewart's granuloma 9


External Ids:

Disease Ontology9 DOID:8580
NCIt41 C7202
ICD9CM28 202.3
MeSH36 D054747

Related Diseases for Malignant Histiocytosis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Histiocytosis family:

malignant histiocytosis

Diseases related to Malignant Histiocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis32.0CSF1, CD68
2leukemia30.6TFRC, SERPINA3, MYB, IL1R1, IL1B, IL1A
3malaria30.4SERPINA3, TFRC
4hepatitis30.4F2, TFRC, LTA
5chronic lymphocytic leukemia30.3LTA, MYB, TFRC
6arthritis30.3IL1B, IL1A
7adult respiratory distress syndrome30.3IL1B, LTA
8acute myelomonocytic leukemia30.2CSF1, CSF1R
9chronic myelomonocytic leukemia30.1CSF1, CSF1R
10monocytic leukemia30.1CSF1, IL1B, IL1R1
11acute leukemia30.0TFRC, MYB, CSF1R, CSF1
12hodgkin's lymphoma30.0TNFRSF8, CSF1R, CD68, LTA
13uveitis30.0IL1R1, IL1A, LTA
14myelodysplastic syndromes30.0CSF1, CSF1R, IL1A, TFRC
15t-cell leukemia29.9TFRC, TNFRSF8, MYB, IL1A, LTA
16thrombocytopenia29.9F2, MYB, IL1R1, IL1A, CSF1
17respiratory failure29.9IL1B, CRP
18systemic lupus erythematosus29.9F2, IL1R1, CRP, LTA
19rheumatoid arthritis29.8TFRC, TNFRSF8, LTA, CD68, CRP, CSF1
20virus associated hemophagocytic syndrome10.5
21mediastinitis10.4
22sarcoma10.4
23lethal midline granuloma10.3
24b-cell lymphomas10.3
25germ cell tumors10.3
26acute lymphocytic leukemia10.2
27eosinophilia10.2
28leishmaniasis10.2
29lymphoblastic lymphoma10.2
30fibrous histiocytoma10.2
31visceral leishmaniasis10.2
32anaplastic large cell lymphoma10.2
33histiocytoma10.2
34meningitis10.2
35panniculitis10.2
36enteropathy-associated t-cell lymphoma10.2
37splenomegaly10.2
38teratoma10.2
39histiocytic sarcoma10.2
40multicentric reticulohistiocytosis10.1CD68
41lymphosarcoma10.1TNFRSF8
42schnitzler syndrome10.1IL1R1
43pigmented villonodular synovitis10.1CSF1R, CSF1
44parapsoriasis10.1
45lymphomatoid granulomatosis10.1
46blau syndrome10.1IL1B
47degenerative disc disease10.1IL1B
48giant cell tumor10.1CSF1R, CSF1
49juvenile rheumatoid arthritis10.1IL1R1, SERPINA3
50adult-onset still's disease10.1CRP

Graphical network of the top 20 diseases related to Malignant Histiocytosis:



Diseases related to malignant histiocytosis

Symptoms for Malignant Histiocytosis

About this section

Drugs & Therapeutics for Malignant Histiocytosis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Histiocytosis

Drug clinical trials:

Search ClinicalTrials for Malignant Histiocytosis

Search NIH Clinical Center for Malignant Histiocytosis

Search CenterWatch for Malignant Histiocytosis

Genetic Tests for Malignant Histiocytosis

About this section
Sources:
23GTR
See all sources

Genetic tests related to Malignant Histiocytosis:

id Genetic test Affiliating Genes
1 Histiocytic Medullary Reticulosis23

Anatomical Context for Malignant Histiocytosis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Malignant Histiocytosis:

34
Spleen, Lymph node, Liver, Lung, T cells, Bone marrow, Bone, Skin, Brain, B cells, Myeloid, Monocytes, Small intestine, Spinal cord, Colon, Thyroid, Pancreas

Animal Models for Malignant Histiocytosis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Malignant Histiocytosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6TFRC, MYB, IL1R1, CSF1, LTA
2MP:00107718.5F2, TFRC, MYB, IL1R1, CSF1R, CSF1
3MP:00053788.2LTA, CSF1, CSF1R, IL1R1, MYB, TFRC
4MP:00053907.8F2, IL1R1, IL1B, CSF1R, CSF1, CD68
5MP:00107687.3F2, TFRC, MYB, IL1R1, IL1B, CSF1R
6MP:00053856.7IL1R1, MYB, TFRC, F2, IL1B, IL1A
7MP:00053766.7IL1B, IL1R1, TFRC, F2, IL1A, CSF1R
8MP:00053976.0MYB, TNFRSF8, TFRC, F2, IL1R1, IL1B
9MP:00053875.5LTA, F2, TFRC, TNFRSF8, MYB, IL1R1

Publications for Malignant Histiocytosis

About this section
Sources:
53PubMed
See all sources

Articles related to Malignant Histiocytosis:

(show top 50)    (show all 350)
idTitleAuthorsYear
1
Malignant histiocytosis of the skin: a case report and review of the literature. (21886719)
2009
2
Establishment of a new canine cell line (CCT) originated from a cutaneous malignant histiocytosis. (12867736)
2003
3
Malignant histiocytosis. (11138619)
2001
4
Malignant histiocytosis in cattle. (11193337)
2000
5
An Asian variant of intravascular lymphomatosis: an updated review of malignant histiocytosis-like B-cell lymphoma. (10342574)
1999
6
True malignant histiocytosis developed during chemotherapy for mediastinal immature teratoma. (8892599)
1996
7
Malignant histiocytosis in childhood: a disease in quest of new nosological criteria. (7603402)
1995
8
Malignant histiocytosis in the leukaemic stage: a new entity (M5c-AML) in the FAB classification? (8127155)
1994
9
Etoposide-based combination chemotherapy in malignant histiocytosis. (7760434)
1994
10
Clinical and radiographic manifestations of canine malignant histiocytosis. (8266626)
1993
11
Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)
1992
12
The unique association of malignant histiocytosis and a primary gonadal germ cell tumor. (1734222)
1992
13
Phenytoin-induced hemocytophagic histiocytosis indistinguishable from malignant histiocytosis. (2035091)
1991
14
Malignant histiocytosis presenting as erythroderma. (2139870)
1990
15
Distribution of three proteinases in tumor cells of malignant histiocytosis]. (2279308)
1990
16
Analysis of spleen cells in malignant histiocytosis in infancy. (20394564)
1990
17
An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis. (2670186)
1989
18
Malignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature. (3416066)
1988
19
Malignant histiocytosis. Clinicopathologic review of 18 cases with immunohistochemical study. (3267356)
1988
20
Malignant histiocytosis. (3065384)
1988
21
Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes. (3260750)
1988
22
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
23
Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. (3950028)
1986
24
Chromosomal and fluorometric DNA analyses of malignant histiocytosis. (3811786)
1986
25
Malignant histiocytosis in Bernese Mountain dogs. (3710888)
1986
26
Immunophenotype analysis of malignant histiocytosis of the intestine. (3512610)
1986
27
Fatal disseminated adenovirus infection featuring liver necrosis and prolonged viremia in an immunosuppressed child with malignant histiocytosis. (2994509)
1985
28
Malignant histiocytosis: report of three cases. (3831202)
1985
29
Malignant histiocytosis: case report and review. (3977614)
1985
30
Erythema annulare centrifugum and malignant histiocytosis--report of a case. (6499278)
1984
31
Malignant histiocytosis--a clinicopathologic study of 5 cases. (6549118)
1984
32
Malignant histiocytosis. Clinical and cytogenetic studies in a newborn and a child. (6883287)
1983
33
Malignant histiocytosis in childhood: morphologic considerations. (6642496)
1983
34
Cutaneous malignant histiocytosis: a clinical and histopathologic study of eight cases, with immunohistochemical analysis. (6826808)
1983
35
Non-B, non-T acute lymphoblastic leukaemia terminating in malignant histiocytosis: a new case and a review of the literature. (6293942)
1982
36
Malignant histiocytosis with slow clinical course. (7134061)
1982
37
Ichthyosis and marrow involvement in malignant histiocytosis of the intestine. (7236527)
1981
38
Malignant histiocytosis --- a case report. (7332304)
1981
39
Respiratory failure in malignant histiocytosis. (7305121)
1981
40
Pulmonary involvement of malignant histiocytosis: a clinicopathologic spectrum. (7246850)
1981
41
Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. (7379013)
1980
42
Malignant histiocytosis in children from the Eastern Mediterranean. (7453672)
1980
43
Malignant histiocytosis showing ascites and recurrent meningeal infiltration. (6931467)
1980
44
Malignant histiocytosis associated with malabsorption. (262066)
1979
45
Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. (225008)
1979
46
Cytomorphologic and cytochemical aspects of malignant histiocytosis with spindle-cell differentiation. A case report. (294074)
1979
47
Lymphoreticular neoplasia in a dog resembling malignant histiocytosis (histiocytic medullary reticulosis) in man. (467080)
1979
48
Sarcomatous variant of malignant histiocytosis; a case report and review of the literature. (735827)
1978
49
Malignant histiocytosis: complete remission with combination chemotherapy. (953957)
1976
50
Malignant histiocytosis with eosinophilia. (4757932)
1973

Variations for Malignant Histiocytosis

About this section
Sources:
1 National Center for Biotechnology Information (Clinvar)
See all sources

Clinvar genetic disease variations for Malignant Histiocytosis:

1 (show all 17)
id Gene Name Type Significance SNP ID Assembly Location
1RAG2NM_000536.3(RAG2): c.686G> A (p.Arg229Gln)single nucleotide variantPathogenicrs121917894GRCh37Chr 11, 36615033: 36615033
2RAG2NM_000536.3(RAG2): c.123C> G (p.Cys41Trp)single nucleotide variantPathogenicrs121917895GRCh37Chr 11, 36615596: 36615596
3RAG2NM_000536.3(RAG2): c.854T> G (p.Met285Arg)single nucleotide variantPathogenicrs121917896GRCh37Chr 11, 36614865: 36614865
4RAG2NM_000536.3(RAG2): c.283G> A (p.Gly95Arg)single nucleotide variantPathogenicrs36001797GRCh37Chr 11, 36615436: 36615436
5RAG2NM_000536.3(RAG2): c.115A> G (p.Arg39Gly)single nucleotide variantPathogenicrs121917897GRCh37Chr 11, 36615604: 36615604
6RAG1NM_000448.2(RAG1): c.1682G> A (p.Arg561His)single nucleotide variantPathogenicrs104894284GRCh37Chr 11, 36596536: 36596536
7RAG1NM_000448.2(RAG1): c.1186C> T (p.Arg396Cys)single nucleotide variantPathogenicrs104894289GRCh37Chr 11, 36596040: 36596040
8RAG1NM_000448.2(RAG1): c.2735A> G (p.Tyr912Cys)single nucleotide variantPathogenicrs104894290GRCh37Chr 11, 36597589: 36597589
9RAG1NM_000448.2(RAG1): c.1187G> A (p.Arg396His)single nucleotide variantPathogenicrs104894291GRCh37Chr 11, 36596041: 36596041
10RAG1NM_000448.2(RAG1): c.1286A> G (p.Asp429Gly)single nucleotide variantPathogenicrs104894292GRCh37Chr 11, 36596140: 36596140
11RAG1NM_000448.2(RAG1): c.1681C> T (p.Arg561Cys)single nucleotide variantPathogenicrs104894285GRCh37Chr 11, 36596535: 36596535
12RAG1NM_000448.2(RAG1): c.2210G> A (p.Arg737His)single nucleotide variantPathogenicrs104894286GRCh37Chr 11, 36597064: 36597064
13RAG1NM_000448.2(RAG1): c.2210G> A (p.Arg737His)single nucleotide variantPathogenicrs104894286GRCh37Chr 11, 36597064: 36597064
14RAG1NM_000448.2(RAG1): c.983G> A (p.Cys328Tyr)single nucleotide variantPathogenicrs121918571GRCh37Chr 11, 36595837: 36595837
15RAG1NM_000448.2(RAG1): c.1566G> T (p.Trp522Cys)single nucleotide variantLikely pathogenic, Pathogenicrs193922461GRCh37Chr 11, 36596420: 36596420
16DCLRE1CNM_001033855.2(DCLRE1C): c.103C> G (p.His35Asp)single nucleotide variantPathogenicrs121908159GRCh37Chr 10, 14995907: 14995907
17DCLRE1CNM_001033855.2(DCLRE1C): c.2T> C (p.Met1Thr)single nucleotide variantPathogenicrs121908158GRCh37Chr 10, 14996008: 14996008

Expression for genes affiliated with Malignant Histiocytosis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malignant Histiocytosis

Search GEO for disease gene expression data for Malignant Histiocytosis.

Pathways for genes affiliated with Malignant Histiocytosis

About this section
Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 31KEGG, 61Thomson Reuters, 62Tocris Bioscience, 55R&D Systems, 56Reactome
See all sources

Pathways related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2LTA
29.9CSF1, CSF1R
39.7IL1R1, IL1A
4
Show member pathways
Serotonin Transporter Activity39
9.5IL1R1, IL1B
59.4IL1A, IL1B
69.4IL1A, IL1B
79.2IL1B, CSF1, LTA
89.2IL1R1, IL1B, LTA
99.2IL1A, IL1B, MYB
109.1CSF1, IL1A, IL1B
119.1IL1B, IL1A, CSF1
12
Show member pathways
9.1LTA, IL1A, IL1B
139.1LTA, IL1A, IL1B
14
Show member pathways
Immune response MIF in innate immunity response61
9.1IL1A, IL1B, IL1R1
15
Show member pathways
9.1IL1R1, IL1B, IL1A
16
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
9.1IL1A, IL1B, IL1R1
17
Show member pathways
9.1IL1A, IL1B, IL1R1
189.1IL1A, IL1B, IL1R1
19
Show member pathways
IL-1 Signaling Pathway39
IL1-mediated signaling events39
9.1IL1R1, IL1B, IL1A
20
Show member pathways
9.1IL1A, IL1B, IL1R1
219.0IL1B, CSF1, CD68
22
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
23
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
8.7IL1R1, IL1B, IL1A, LTA
24
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
25
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
26
Show member pathways
thioredoxin pathway39
8.7F2, SERPINA3, IL1B, CRP
278.5IL1R1, IL1B, IL1A, CSF1R, CSF1
288.1CSF1, TFRC, IL1R1, IL1B, IL1A, CSF1R
29
Show member pathways
8.1F2, IL1R1, IL1B, IL1A, CSF1R, LTA
30
Show member pathways
7.4TNFRSF8, IL1R1, IL1B, IL1A, CSF1R, CSF1
31
Show member pathways
7.4TNFRSF8, IL1R1, IL1B, IL1A, CSF1R, CSF1
32
Show member pathways
7.4CSF1, CSF1R, IL1A, IL1B, IL1R1, TNFRSF8
33
Show member pathways
7.0F2, TNFRSF8, IL1R1, IL1B, IL1A, CSF1R

Compounds for genes affiliated with Malignant Histiocytosis

About this section
Sources:
46Novoseek, 62Tocris Bioscience, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB
See all sources

Compounds related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1methylcellulose469.4MYB, IL1A, TFRC, CSF1
24-ipp629.3IL1A, IL1B, IL1R1
3anakinra46 1210.2CRP, IL1B, IL1R1
4gm-csf46 3010.2CSF1, CSF1R, IL1A, IL1B
5git 27629.2IL1B, IL1A, IL1R1
6gold sodium thiomalate469.1IL1R1, IL1B, IL1A
7ionomycin469.1LTA, IL1A, SERPINA3, TFRC, CSF1
8pirfenidone46 6210.1IL1R1, IL1B, IL1A
9pentoxifylline46 1210.0IL1R1, IL1A, LTA, IL1B
10infliximab46 52 1211.0LTA, CRP, IL1B, IL1R1
11tenidap46 3010.0IL1B, IL1R1, IL1A, CRP
1212-o-tetradecanoylphorbol 13-acetate469.0IL1A, CSF1R, MYB, CSF1, IL1R1, LTA
13il 10468.9LTA, CSF1, IL1R1, IL1B, IL1A
14fmlp468.9IL1B, SERPINA3, LTA, CSF1, IL1A
15hydroxyurea46 52 1210.9F2, CSF1, TFRC, IL1A
16etanercept46 52 1210.8LTA, CRP, CSF1, IL1R1, IL1B
17polyethylene glycol468.8CRP, IL1A, IL1R1, TFRC, F2
18vitamin d468.7TFRC, IL1A, CSF1R, LTA, IL1R1
19progesterone46 30 62 25 1212.7LTA, MYB, IL1R1, SERPINA3, IL1A, CSF1R
20sulfasalazine30 46 52 1211.7CSF1, IL1B, IL1A, CRP, IL1R1
21hyaluronic acid46 259.7IL1R1, IL1B, IL1A, LTA, F2
22ascorbic acid46 259.7CSF1, IL1A, IL1R1, TFRC, CRP
23rantes468.7IL1B, IL1A, IL1R1, LTA, CSF1
24acetylcholine46 52 30 25 1212.6SERPINA3, LTA, CRP, TFRC, IL1A, CSF1
25rapamycin468.6CSF1, TFRC, MYB, IL1R1, IL1A, CRP
26h2o2468.6CSF1, IL1A, TFRC, MYB, IL1R1, LTA
27methotrexate52 46 1210.6F2, IL1R1, IL1B, SERPINA3, CRP
28aspirin46 52 30 2511.6CSF1, IL1R1, CRP, F2, IL1B
29endotoxin468.6IL1R1, CRP, IL1B, IL1A, LTA
30lactate468.5CRP, CSF1, IL1R1, F2, TFRC, LTA
31leukotriene b446 62 2510.5IL1A, IL1B, IL1R1, CSF1
32indomethacin46 30 62 1211.5TFRC, IL1B, IL1A, CSF1, LTA, IL1R1
33calcitriol46 62 25 1211.4F2, IL1A, TFRC, LTA, CSF1, IL1B
34ivig468.4CRP, LTA, IL1R1, IL1B, IL1A, CSF1
35estrogen468.4F2, TFRC, SERPINA3, LTA, MYB, IL1R1
36alanine468.3MYB, IL1R1, F2, TFRC, SERPINA3, CSF1
37n acetylcysteine468.3F2, TFRC, IL1R1, IL1B, CSF1, CRP
38actinomycin d468.2IL1B, TFRC, MYB, LTA, CSF1, IL1R1
39pge2468.2IL1B, CSF1, CSF1R, TFRC, LTA, IL1A
40neopterin468.0LTA, IL1R1, IL1B, IL1A, CSF1, CRP
41creatinine468.0F2, TFRC, SERPINA3, IL1R1, CRP, PDLIM3
42cyclosporin a46 30 629.9TNFRSF8, F2, TFRC, MYB, IL1R1, IL1A
43dexamethasone46 52 30 1210.8IL1A, CSF1R, CSF1, MYB, SERPINA3, TFRC
44retinoic acid46 258.7TFRC, SERPINA3, IL1R1, IL1B, MYB, IL1A
45thymidine46 258.7TFRC, IL1A, TNFRSF8, MYB, IL1R1, IL1B
46paraffin467.7LTA, CD68, CSF1R, IL1R1, SERPINA3, TNFRSF8
47lipid467.5LTA, TNFRSF8, CSF1R, SERPINA3, CD68, CRP
48cycloheximide467.5IL1R1, IL1B, TFRC, IL1A, CSF1R, CSF1
49vegf467.5IL1B, TFRC, MYB, IL1R1, IL1A, LTA
50serine467.1IL1R1, IL1A, LTA, CSF1, CSF1R, MYB

GO Terms for genes affiliated with Malignant Histiocytosis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.1SERPINA3, TFRC, F2
2membraneGO:0160208.5TFRC, IL1R1, CSF1, CD68, LTA
3extracellular spaceGO:0056157.6LTA, F2, TFRC, IL1B, IL1A, CSF1
4extracellular regionGO:0055767.5F2, TFRC, SERPINA3, IL1R1, IL1B, IL1A
5plasma membraneGO:0058867.5TFRC, TNFRSF8, IL1R1, CSF1R, CSF1, CD68

Biological processes related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1macrophage differentiationGO:03022510.1CSF1, CSF1R
2osteoclast differentiationGO:0303169.8TFRC, CSF1R, CSF1
3fever generationGO:0016609.6IL1A, IL1B
4defense response to Gram-positive bacteriumGO:0508309.6LTA, CRP
5ectopic germ cell programmed cell deathGO:0352349.6IL1A, IL1B
6positive regulation of interleukin-2 biosynthetic processGO:0450869.6IL1A, IL1B
7acute-phase responseGO:0069539.5CRP, SERPINA3, F2
8positive regulation vascular endothelial growth factor productionGO:0105759.5IL1A, IL1B
9cellular response to organic substanceGO:0713109.4IL1B, CD68
10positive regulation of mitosisGO:0458409.4IL1B, IL1A
11positive regulation of protein phosphorylationGO:0019349.4F2, IL1B, CSF1R
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.1IL1A, IL1B
13cytokine-mediated signaling pathwayGO:0192219.0CSF1R, IL1A, IL1B
14inflammatory responseGO:0069548.4CRP, CSF1, CSF1R, IL1A, IL1B, SERPINA3

Molecular functions related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.4IL1A, IL1B
2cytokine activityGO:0051258.5LTA, CSF1, IL1A, IL1B

Products for genes affiliated with Malignant Histiocytosis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Malignant Histiocytosis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet