MCID: MLG054
MIFTS: 55

Malignant Histiocytosis malady

Cancer diseases, Immune diseases, Rare diseases categories

Aliases & Classifications for Malignant Histiocytosis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 22GTR, 61UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 33MeSH, 25ICD10
See all sources

Aliases & Descriptions for Malignant Histiocytosis:

Name: Malignant Histiocytosis 8 10 44 61
Histiocytic Medullary Reticulosis 8 22
Nasal Type Extranodal Nk/t-Cell Lymphoma 61
 
Malignant Midline Reticulosis 8
Malignant Reticulosis 8
Stewart's Granuloma 8


Classifications:



External Ids:

Disease Ontology8 DOID:8580
NCIt39 C7202
ICD9CM27 202.3
MeSH33 D054747
ICD1025 C86.0

Summaries for Malignant Histiocytosis

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Wikipedia:64 Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary... more...

MalaCards based summary: Malignant Histiocytosis, also known as histiocytic medullary reticulosis, is related to histiocytosis and myelodysplastic syndrome. An important gene associated with Malignant Histiocytosis is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are TRAF Pathway and Signaling events mediated by TCPTP. The compounds methylcellulose and 4-ipp have been mentioned in the context of this disorder. Affiliated tissues include t cells, spleen and lymph node, and related mouse phenotypes are liver/biliary system and integument.

Related Diseases for Malignant Histiocytosis

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Diseases in the Histiocytosis family:

malignant histiocytosis

Diseases related to Malignant Histiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis32.8CD68
2myelodysplastic syndrome30.7CSF1, CSF1R
3acute myelomonocytic leukemia30.7CSF1, CSF1R
4chronic myelomonocytic leukemia30.6CSF1R, CSF1
5chronic lymphocytic leukemia30.5LTA, TFRC, MYB
6arthritis30.4IL1A, IL1B
7hepatitis30.4F2, TFRC, LTA
8malaria30.3IL1R1, IL1B, IL1A
9monocytic leukemia30.2CSF1, IL1B, IL1R1
10acute leukemia30.2MYB, CSF1R, CSF1, TFRC
11uveitis30.1LTA, IL1A, IL1R1
12systemic lupus erythematosus29.9CRP, F2, LTA, IL1R1
13t-cell leukemia29.8LTA, TFRC, MYB, IL1A, TNFRSF8
14leukemia29.7TFRC, MYB, IL1R1, CSF1, IL1B, LTA
15thrombocytopenia29.7MYB, IL1R1, F2, CSF1, IL1A
16respiratory failure29.6IL1B, CRP
17rheumatoid arthritis28.3LTA, CD68, CSF1, IL1A, IL1B, MYB
18multicentric reticulohistiocytosis10.5CD68
19lymphosarcoma10.5TNFRSF8
20virus associated hemophagocytic syndrome10.5
21schnitzler syndrome10.5IL1R1
22pigmented villonodular synovitis10.4CSF1R, CSF1
23blau syndrome10.4IL1B
24intervertebral disc disease10.4IL1B
25giant cell tumor10.4CSF1R, CSF1
26langerhans-cell histiocytosis10.4CD68, CSF1
27systemic onset juvenile idiopathic arthritis10.4IL1R1, SERPINA3
28mediastinitis10.4
29sarcoma10.4
30b-cell lymphomas10.3
31lethal midline granuloma10.3
32adult-onset still's disease10.3CRP
33malignant fibroxanthoma10.3TNFRSF8, SERPINA3, CD68
34muckle-wells syndrome10.3IL1R1, IL1B
35refractory anemia10.3TFRC, CSF1
36hematologic cancer10.3CSF1R, TNFRSF8, CSF1
37lymphoblastic lymphoma10.3
38eosinophilia10.3
39leishmaniasis10.3
40acute graft versus host disease10.3LTA, IL1R1
41familial cold autoinflammatory syndrome10.3IL1B, IL1R1
42peripheral t-cell lymphoma10.2TNFRSF8, LTA
43cinca syndrome10.2IL1R1, IL1B
44cutaneous t cell lymphoma10.2MYB, TFRC, TNFRSF8
45secondary syphilis10.2CSF1, PDLIM3, LTA
46idiopathic myopathy10.2IL1A, IL1R1
47alopecia areata10.2IL1R1, IL1A
48reticulosarcoma10.2CD68, TNFRSF8
49periodontitis10.2IL1A, IL1B
50polymyalgia rheumatica10.2CRP, SERPINA3

Graphical network of the top 20 diseases related to Malignant Histiocytosis:



Diseases related to malignant histiocytosis

Symptoms for Malignant Histiocytosis

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Drugs & Therapeutics for Malignant Histiocytosis

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Drug clinical trials:

Search ClinicalTrials for Malignant Histiocytosis

Search NIH Clinical Center for Malignant Histiocytosis

Genetic Tests for Malignant Histiocytosis

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Genetic tests related to Malignant Histiocytosis:

id Genetic test Affiliating Genes
1 Histiocytic Medullary Reticulosis22

Anatomical Context for Malignant Histiocytosis

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MalaCards organs/tissues related to Malignant Histiocytosis:

31
T cells, Spleen, Lymph node, Liver, Lung, Bone marrow, Bone, Brain, Skin, B cells, Myeloid, Monocytes, Small intestine, Spinal cord, Colon, Pancreas, Thyroid, Neutrophil

Animal Models for Malignant Histiocytosis or affiliated genes

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MGI Mouse Phenotypes related to Malignant Histiocytosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6MYB, IL1R1, CSF1, LTA, TFRC
2MP:00107718.5TFRC, CSF1, MYB, CSF1R, F2, IL1R1
3MP:00053788.2IL1R1, F2, TFRC, MYB, CSF1R, CSF1
4MP:00053907.8F2, CD68, CSF1, CSF1R, IL1B, LTA
5MP:00107687.3CSF1, F2, TFRC, IL1B, CSF1R, PDLIM3
6MP:00053856.7LTA, F2, TFRC, PDLIM3, CRP, CSF1
7MP:00053766.7TFRC, IL1R1, IL1B, CSF1R, CSF1, PDLIM3
8MP:00053976.0CD68, LTA, F2, TFRC, TNFRSF8, MYB
9MP:00053875.5F2, LTA, TNFRSF8, MYB, IL1B, CD68

Publications for Malignant Histiocytosis

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Articles related to Malignant Histiocytosis:

(show top 50)    (show all 348)
idTitleAuthorsYear
1
Establishment of a new canine cell line (CCT) originated from a cutaneous malignant histiocytosis. (12867736)
2003
2
Malignant histiocytosis. (11138619)
2001
3
Malignant histiocytosis in cattle. (11193337)
2000
4
An Asian variant of intravascular lymphomatosis: an updated review of malignant histiocytosis-like B-cell lymphoma. (10342574)
1999
5
True malignant histiocytosis developed during chemotherapy for mediastinal immature teratoma. (8892599)
1996
6
Malignant histiocytosis in childhood: a disease in quest of new nosological criteria. (7603402)
1995
7
Malignant histiocytosis in the leukaemic stage: a new entity (M5c-AML) in the FAB classification? (8127155)
1994
8
Etoposide-based combination chemotherapy in malignant histiocytosis. (7760434)
1994
9
Clinical and radiographic manifestations of canine malignant histiocytosis. (8266626)
1993
10
Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)
1992
11
The unique association of malignant histiocytosis and a primary gonadal germ cell tumor. (1734222)
1992
12
Phenytoin-induced hemocytophagic histiocytosis indistinguishable from malignant histiocytosis. (2035091)
1991
13
Malignant histiocytosis presenting as erythroderma. (2139870)
1990
14
Distribution of three proteinases in tumor cells of malignant histiocytosis]. (2279308)
1990
15
Analysis of spleen cells in malignant histiocytosis in infancy. (20394564)
1990
16
An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis. (2670186)
1989
17
Malignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature. (3416066)
1988
18
Malignant histiocytosis. Clinicopathologic review of 18 cases with immunohistochemical study. (3267356)
1988
19
Malignant histiocytosis. (3065384)
1988
20
Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes. (3260750)
1988
21
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
22
Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. (3950028)
1986
23
Chromosomal and fluorometric DNA analyses of malignant histiocytosis. (3811786)
1986
24
Malignant histiocytosis in Bernese Mountain dogs. (3710888)
1986
25
Immunophenotype analysis of malignant histiocytosis of the intestine. (3512610)
1986
26
Immature phenotypic conversion in a patient with malignant histiocytosis. (3766080)
1986
27
Fatal disseminated adenovirus infection featuring liver necrosis and prolonged viremia in an immunosuppressed child with malignant histiocytosis. (2994509)
1985
28
Malignant histiocytosis: report of three cases. (3831202)
1985
29
Malignant histiocytosis: case report and review. (3977614)
1985
30
Erythema annulare centrifugum and malignant histiocytosis--report of a case. (6499278)
1984
31
Malignant histiocytosis--a clinicopathologic study of 5 cases. (6549118)
1984
32
Malignant histiocytosis. Clinical and cytogenetic studies in a newborn and a child. (6883287)
1983
33
Malignant histiocytosis in childhood: morphologic considerations. (6642496)
1983
34
Cutaneous malignant histiocytosis: a clinical and histopathologic study of eight cases, with immunohistochemical analysis. (6826808)
1983
35
Non-B, non-T acute lymphoblastic leukaemia terminating in malignant histiocytosis: a new case and a review of the literature. (6293942)
1982
36
Malignant histiocytosis with slow clinical course. (7134061)
1982
37
Ichthyosis and marrow involvement in malignant histiocytosis of the intestine. (7236527)
1981
38
Malignant histiocytosis --- a case report. (7332304)
1981
39
Respiratory failure in malignant histiocytosis. (7305121)
1981
40
Pulmonary involvement of malignant histiocytosis: a clinicopathologic spectrum. (7246850)
1981
41
Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. (7379013)
1980
42
Malignant histiocytosis in children from the Eastern Mediterranean. (7453672)
1980
43
Null cell (non-T, non-B) acute lymphoblastic leukemia terminating as malignant histiocytosis. (6929651)
1980
44
Malignant histiocytosis associated with malabsorption. (262066)
1979
45
Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. (225008)
1979
46
Cytomorphologic and cytochemical aspects of malignant histiocytosis with spindle-cell differentiation. A case report. (294074)
1979
47
Lymphoreticular neoplasia in a dog resembling malignant histiocytosis (histiocytic medullary reticulosis) in man. (467080)
1979
48
Sarcomatous variant of malignant histiocytosis; a case report and review of the literature. (735827)
1978
49
Malignant histiocytosis: complete remission with combination chemotherapy. (953957)
1976
50
Malignant histiocytosis with eosinophilia. (4757932)
1973

Variations for Malignant Histiocytosis

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Expression for genes affiliated with Malignant Histiocytosis

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Search GEO for disease gene expression data for Malignant Histiocytosis.

Pathways for genes affiliated with Malignant Histiocytosis

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Pathways related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2LTA
29.9CSF1, CSF1R
39.7IL1A, IL1R1
4
Show member pathways
Serotonin Transporter Activity36
9.5IL1B, IL1R1
59.4IL1A, IL1B
69.4IL1B, IL1A
79.2IL1B, LTA, CSF1
89.2LTA, IL1R1, IL1B
99.2IL1A, IL1B, MYB
109.1IL1B, IL1A, CSF1
119.1IL1B, CSF1, IL1A
12
Show member pathways
9.1IL1A, IL1B, LTA
139.1LTA, IL1B, IL1A
149.1IL1R1, IL1A, IL1B
15
Show member pathways
Immune response MIF in innate immunity response59
9.1IL1A, IL1R1, IL1B
16
Show member pathways
9.1IL1A, IL1B, IL1R1
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways59
Immune response IL 1 signaling pathway59
9.1IL1R1, IL1B, IL1A
18
Show member pathways
9.1IL1R1, IL1B, IL1A
19
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.1IL1R1, IL1B, IL1A
20
Show member pathways
9.1IL1A, IL1B, IL1R1
219.0IL1B, CD68, CSF1
22
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
23
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
24
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
8.7IL1A, IL1B, IL1R1, LTA
25
Show member pathways
8.7LTA, IL1R1, IL1B, IL1A
26
Show member pathways
thioredoxin pathway36
8.7SERPINA3, IL1B, CRP, F2
278.5CSF1, IL1B, IL1A, CSF1R, IL1R1
288.1IL1B, IL1R1, TFRC, IL1A, CSF1R, CSF1
29
Show member pathways
8.1IL1A, IL1B, CSF1R, LTA, F2, IL1R1
30
Show member pathways
7.4IL1A, IL1B, IL1R1, TNFRSF8, CSF1R, CSF1
31
Show member pathways
7.4TNFRSF8, IL1R1, IL1B, IL1A, CSF1R, CSF1
32
Show member pathways
7.4CSF1, CSF1R, IL1B, IL1R1, LTA, TNFRSF8
33
Show member pathways
7.0IL1B, TNFRSF8, IL1R1, IL1A, CSF1R, CSF1

Compounds for genes affiliated with Malignant Histiocytosis

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Compounds related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1methylcellulose449.4MYB, IL1A, TFRC, CSF1
24-ipp609.3IL1A, IL1B, IL1R1
3anakinra44 1110.2CRP, IL1B, IL1R1
4gm-csf44 2810.2CSF1, CSF1R, IL1A, IL1B
5git 27609.2IL1B, IL1A, IL1R1
6gold sodium thiomalate449.1IL1R1, IL1B, IL1A
7ionomycin449.1LTA, IL1A, SERPINA3, TFRC, CSF1
8pirfenidone44 6010.1IL1R1, IL1B, IL1A
9pentoxifylline44 1110.0IL1R1, IL1A, LTA, IL1B
10infliximab44 50 1111.0LTA, CRP, IL1B, IL1R1
11tenidap44 2810.0IL1B, IL1R1, IL1A, CRP
1212-o-tetradecanoylphorbol 13-acetate449.0IL1A, CSF1R, MYB, CSF1, IL1R1, LTA
13il 10448.9LTA, CSF1, IL1R1, IL1B, IL1A
14fmlp448.9IL1B, SERPINA3, LTA, CSF1, IL1A
15hydroxyurea44 50 1110.9F2, CSF1, TFRC, IL1A
16etanercept44 50 1110.8LTA, CRP, CSF1, IL1R1, IL1B
17polyethylene glycol448.8CRP, IL1A, IL1R1, TFRC, F2
18vitamin d448.7TFRC, IL1A, CSF1R, LTA, IL1R1
19progesterone44 28 60 24 1112.7LTA, MYB, IL1R1, SERPINA3, IL1A, CSF1R
20sulfasalazine28 44 50 1111.7CSF1, IL1B, IL1A, CRP, IL1R1
21hyaluronic acid44 249.7IL1R1, IL1B, IL1A, LTA, F2
22ascorbic acid44 249.7CSF1, IL1A, IL1R1, TFRC, CRP
23rantes448.7IL1B, IL1A, IL1R1, LTA, CSF1
24acetylcholine44 50 28 24 1112.6SERPINA3, LTA, CRP, TFRC, IL1A, CSF1
25rapamycin448.6CSF1, TFRC, MYB, IL1R1, IL1A, CRP
26h2o2448.6CSF1, IL1A, TFRC, MYB, IL1R1, LTA
27methotrexate50 44 1110.6F2, IL1R1, IL1B, SERPINA3, CRP
28aspirin44 50 28 2411.6CSF1, IL1R1, CRP, F2, IL1B
29endotoxin448.6IL1R1, CRP, IL1B, IL1A, LTA
30lactate448.5CRP, CSF1, IL1R1, F2, TFRC, LTA
31leukotriene b444 60 2410.5IL1A, IL1B, IL1R1, CSF1
32indomethacin44 28 60 1111.5TFRC, IL1B, IL1A, CSF1, LTA, IL1R1
33calcitriol44 60 24 1111.4F2, IL1A, TFRC, LTA, CSF1, IL1B
34ivig448.4CRP, LTA, IL1R1, IL1B, IL1A, CSF1
35estrogen448.4F2, TFRC, SERPINA3, LTA, MYB, IL1R1
36alanine448.3MYB, IL1R1, F2, TFRC, SERPINA3, CSF1
37n acetylcysteine448.3F2, TFRC, IL1R1, IL1B, CSF1, CRP
38actinomycin d448.2IL1B, TFRC, MYB, LTA, CSF1, IL1R1
39pge2448.2IL1B, CSF1, CSF1R, TFRC, LTA, IL1A
40neopterin448.0LTA, IL1R1, IL1B, IL1A, CSF1, CRP
41creatinine448.0F2, TFRC, SERPINA3, IL1R1, CRP, PDLIM3
42cyclosporin a44 28 609.9TNFRSF8, F2, TFRC, MYB, IL1R1, IL1A
43dexamethasone44 50 28 1110.8IL1A, CSF1R, CSF1, MYB, SERPINA3, TFRC
44retinoic acid44 248.7TFRC, SERPINA3, IL1R1, IL1B, MYB, IL1A
45thymidine44 248.7TFRC, IL1A, TNFRSF8, MYB, IL1R1, IL1B
46paraffin447.7LTA, CD68, CSF1R, IL1R1, SERPINA3, TNFRSF8
47lipid447.5LTA, TNFRSF8, CSF1R, SERPINA3, CD68, CRP
48cycloheximide447.5IL1R1, IL1B, TFRC, IL1A, CSF1R, CSF1
49vegf447.5IL1B, TFRC, MYB, IL1R1, IL1A, LTA
50serine447.1IL1R1, IL1A, LTA, CSF1, CSF1R, MYB

GO Terms for genes affiliated with Malignant Histiocytosis

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Cellular components related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.1SERPINA3, TFRC, F2
2membraneGO:00160208.5TFRC, IL1R1, CSF1, CD68, LTA
3extracellular spaceGO:00056157.6LTA, F2, TFRC, IL1B, IL1A, CSF1
4extracellular regionGO:00055767.5F2, TFRC, SERPINA3, IL1R1, IL1B, IL1A
5plasma membraneGO:00058867.5TFRC, TNFRSF8, IL1R1, CSF1R, CSF1, CD68

Biological processes related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1macrophage differentiationGO:003022510.1CSF1, CSF1R
2osteoclast differentiationGO:00303169.8TFRC, CSF1R, CSF1
3fever generationGO:00016609.6IL1A, IL1B
4defense response to Gram-positive bacteriumGO:00508309.6LTA, CRP
5ectopic germ cell programmed cell deathGO:00352349.6IL1A, IL1B
6positive regulation of interleukin-2 biosynthetic processGO:00450869.6IL1A, IL1B
7acute-phase responseGO:00069539.5CRP, SERPINA3, F2
8positive regulation vascular endothelial growth factor productionGO:00105759.5IL1A, IL1B
9cellular response to organic substanceGO:00713109.4IL1B, CD68
10positive regulation of mitosisGO:00458409.4IL1B, IL1A
11positive regulation of protein phosphorylationGO:00019349.4F2, IL1B, CSF1R
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.1IL1A, IL1B
13cytokine-mediated signaling pathwayGO:00192219.0CSF1R, IL1A, IL1B
14inflammatory responseGO:00069548.4CRP, CSF1, CSF1R, IL1A, IL1B, SERPINA3

Molecular functions related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.4IL1A, IL1B
2cytokine activityGO:00051258.5LTA, CSF1, IL1A, IL1B

Sources for Malignant Histiocytosis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet