MCID: MLG054
MIFTS: 63

Malignant Histiocytosis malady

Immune diseases, Rare diseases categories
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Summaries for Malignant Histiocytosis

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Wikipedia:65 Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary... more...

MalaCards based summary: Malignant Histiocytosis, also known as histiocytic medullary reticulosis, is related to histiocytosis and malaria. An important gene associated with Malignant Histiocytosis is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are TRAF Pathway and Signaling events mediated by TCPTP. The compounds methylcellulose and 4-ipp have been mentioned in the context of this disorder. Affiliated tissues include spleen, lymph node and liver, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Malignant Histiocytosis

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH
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Malignant Histiocytosis, Aliases & Descriptions:

Name: Malignant Histiocytosis 8 10 44 62
Histiocytic Medullary Reticulosis 8 22 62
Malignant Midline Reticulosis 8 62
 
Malignant Reticulosis 8
Stewart's Granuloma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology8 DOID:8580
NCIt39 C7202
ICD9CM27 202.3
MeSH34 D054747

Related Diseases for Malignant Histiocytosis

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Diseases in the Histiocytosis family:

malignant histiocytosis

Diseases related to Malignant Histiocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 165)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis32.8CD68
2malaria30.8SERPINA3, TFRC
3acute myelomonocytic leukemia30.7CSF1, CSF1R
4chronic lymphocytic leukemia30.5LTA, MYB, TFRC
5arthritis30.4IL1B, IL1A
6adult respiratory distress syndrome30.4IL1B, LTA
7hepatitis30.4F2, TFRC, LTA
8monocytic leukemia30.2CSF1, IL1B, IL1R1
9acute leukemia30.2TFRC, MYB, CSF1R, CSF1
10hodgkin's lymphoma30.2TNFRSF8, CSF1R, CD68, LTA
11uveitis30.1IL1R1, IL1A, LTA
12myelodysplastic syndromes30.0CSF1, CSF1R, IL1A, TFRC
13systemic lupus erythematosus29.9F2, IL1R1, CRP, LTA
14t-cell leukemia29.8TFRC, TNFRSF8, MYB, IL1A, LTA
15leukemia29.8TFRC, SERPINA3, MYB, IL1R1, IL1B, IL1A
16thrombocytopenia29.7F2, MYB, IL1R1, IL1A, CSF1
17respiratory failure29.7IL1B, CRP
18rheumatoid arthritis28.3TFRC, TNFRSF8, LTA, CD68, CRP, CSF1
19multicentric reticulohistiocytosis10.5CD68
20lymphosarcoma10.5TNFRSF8
21virus associated hemophagocytic syndrome10.5
22schnitzler syndrome10.5IL1R1
23pigmented villonodular synovitis10.5CSF1R, CSF1
24blau syndrome10.4IL1B
25degenerative disc disease10.4IL1B
26giant cell tumor10.4CSF1R, CSF1
27langerhans-cell histiocytosis10.4CSF1, CD68
28juvenile rheumatoid arthritis10.4IL1R1, SERPINA3
29pdgfrb-associated chronic eosinophilic leukemia10.4CSF1, CSF1R
30mediastinitis10.4
31sarcoma10.4
32b-cell lymphomas10.3
33lethal midline granuloma10.3
34germ cell tumors10.3
35adult-onset still's disease10.3CRP
36malignant fibroxanthoma10.3TNFRSF8, SERPINA3, CD68
37refractory anemia10.3TFRC, CSF1
38muckle-wells syndrome10.3IL1B, IL1R1
39hematologic cancer10.3CSF1, CSF1R, TNFRSF8
40acute graft versus host disease10.3LTA, IL1R1
41familial cold autoinflammatory syndrome10.3IL1B, IL1R1
42acute lymphocytic leukemia10.3
43lymphoblastic lymphoma10.3
44eosinophilia10.3
45leishmaniasis10.3
46chronic infantile neurological cutaneous articular syndrome10.2IL1B, IL1R1
47cutaneous t cell lymphoma10.2MYB, TNFRSF8, TFRC
48secondary syphilis10.2CSF1, PDLIM3, LTA
49peripheral t-cell lymphoma10.2TNFRSF8, LTA
50idiopathic myopathy10.2IL1A, IL1R1

Graphical network of the top 20 diseases related to Malignant Histiocytosis:



Diseases related to malignant histiocytosis

Symptoms for Malignant Histiocytosis

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Drugs & Therapeutics for Malignant Histiocytosis

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Drug clinical trials:

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Search NIH Clinical Center for Malignant Histiocytosis

Genetic Tests for Malignant Histiocytosis

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Genetic tests related to Malignant Histiocytosis:

id Genetic test Affiliating Genes
1 Histiocytic Medullary Reticulosis22

Anatomical Context for Malignant Histiocytosis

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MalaCards organs/tissues related to Malignant Histiocytosis:

32
Spleen, Lymph node, Liver, Lung, T cells, Bone marrow, Bone, Brain, Skin, B cells, Myeloid, Monocytes, Small intestine, Spinal cord, Colon, Pancreas, Thyroid, Neutrophil

Animal Models for Malignant Histiocytosis or affiliated genes

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MGI Mouse Phenotypes related to Malignant Histiocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6TFRC, MYB, IL1R1, CSF1, LTA
2MP:00107718.5F2, TFRC, MYB, IL1R1, CSF1R, CSF1
3MP:00053788.2LTA, CSF1, CSF1R, IL1R1, MYB, TFRC
4MP:00053907.8F2, IL1R1, IL1B, CSF1R, CSF1, CD68
5MP:00107687.3F2, TFRC, MYB, IL1R1, IL1B, CSF1R
6MP:00053856.7IL1R1, MYB, TFRC, F2, IL1B, IL1A
7MP:00053766.7IL1B, IL1R1, TFRC, F2, IL1A, CSF1R
8MP:00053976.0MYB, TNFRSF8, TFRC, F2, IL1R1, IL1B
9MP:00053875.5LTA, F2, TFRC, TNFRSF8, MYB, IL1R1

Publications for Malignant Histiocytosis

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Articles related to Malignant Histiocytosis:

(show top 50)    (show all 348)
idTitleAuthorsYear
1
Malignant histiocytosis of the skin: a case report and review of the literature. (21886719)
2009
2
Establishment of a new canine cell line (CCT) originated from a cutaneous malignant histiocytosis. (12867736)
2003
3
Malignant histiocytosis. (11138619)
2001
4
Malignant histiocytosis in cattle. (11193337)
2000
5
An Asian variant of intravascular lymphomatosis: an updated review of malignant histiocytosis-like B-cell lymphoma. (10342574)
1999
6
True malignant histiocytosis developed during chemotherapy for mediastinal immature teratoma. (8892599)
1996
7
Malignant histiocytosis in childhood: a disease in quest of new nosological criteria. (7603402)
1995
8
Malignant histiocytosis in the leukaemic stage: a new entity (M5c-AML) in the FAB classification? (8127155)
1994
9
Etoposide-based combination chemotherapy in malignant histiocytosis. (7760434)
1994
10
Clinical and radiographic manifestations of canine malignant histiocytosis. (8266626)
1993
11
Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)
1992
12
The unique association of malignant histiocytosis and a primary gonadal germ cell tumor. (1734222)
1992
13
Phenytoin-induced hemocytophagic histiocytosis indistinguishable from malignant histiocytosis. (2035091)
1991
14
Malignant histiocytosis presenting as erythroderma. (2139870)
1990
15
Distribution of three proteinases in tumor cells of malignant histiocytosis]. (2279308)
1990
16
Analysis of spleen cells in malignant histiocytosis in infancy. (20394564)
1990
17
An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis. (2670186)
1989
18
Malignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature. (3416066)
1988
19
Malignant histiocytosis. Clinicopathologic review of 18 cases with immunohistochemical study. (3267356)
1988
20
Malignant histiocytosis. (3065384)
1988
21
Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes. (3260750)
1988
22
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
23
Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. (3950028)
1986
24
Chromosomal and fluorometric DNA analyses of malignant histiocytosis. (3811786)
1986
25
Malignant histiocytosis in Bernese Mountain dogs. (3710888)
1986
26
Immunophenotype analysis of malignant histiocytosis of the intestine. (3512610)
1986
27
Fatal disseminated adenovirus infection featuring liver necrosis and prolonged viremia in an immunosuppressed child with malignant histiocytosis. (2994509)
1985
28
Malignant histiocytosis: report of three cases. (3831202)
1985
29
Malignant histiocytosis: case report and review. (3977614)
1985
30
Erythema annulare centrifugum and malignant histiocytosis--report of a case. (6499278)
1984
31
Malignant histiocytosis--a clinicopathologic study of 5 cases. (6549118)
1984
32
Malignant histiocytosis. Clinical and cytogenetic studies in a newborn and a child. (6883287)
1983
33
Malignant histiocytosis in childhood: morphologic considerations. (6642496)
1983
34
Cutaneous malignant histiocytosis: a clinical and histopathologic study of eight cases, with immunohistochemical analysis. (6826808)
1983
35
Non-B, non-T acute lymphoblastic leukaemia terminating in malignant histiocytosis: a new case and a review of the literature. (6293942)
1982
36
Malignant histiocytosis with slow clinical course. (7134061)
1982
37
Ichthyosis and marrow involvement in malignant histiocytosis of the intestine. (7236527)
1981
38
Malignant histiocytosis --- a case report. (7332304)
1981
39
Respiratory failure in malignant histiocytosis. (7305121)
1981
40
Pulmonary involvement of malignant histiocytosis: a clinicopathologic spectrum. (7246850)
1981
41
Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. (7379013)
1980
42
Malignant histiocytosis in children from the Eastern Mediterranean. (7453672)
1980
43
Malignant histiocytosis showing ascites and recurrent meningeal infiltration. (6931467)
1980
44
Malignant histiocytosis associated with malabsorption. (262066)
1979
45
Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. (225008)
1979
46
Cytomorphologic and cytochemical aspects of malignant histiocytosis with spindle-cell differentiation. A case report. (294074)
1979
47
Lymphoreticular neoplasia in a dog resembling malignant histiocytosis (histiocytic medullary reticulosis) in man. (467080)
1979
48
Sarcomatous variant of malignant histiocytosis; a case report and review of the literature. (735827)
1978
49
Malignant histiocytosis: complete remission with combination chemotherapy. (953957)
1976
50
Malignant histiocytosis with eosinophilia. (4757932)
1973

Variations for Malignant Histiocytosis

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Expression for genes affiliated with Malignant Histiocytosis

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Expression patterns in normal tissues for genes affiliated with Malignant Histiocytosis

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Pathways for genes affiliated with Malignant Histiocytosis

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Pathways related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2LTA
29.9CSF1, CSF1R
39.7IL1R1, IL1A
4
Show member pathways
Serotonin Transporter Activity37
9.5IL1R1, IL1B
59.4IL1A, IL1B
69.4IL1A, IL1B
79.2IL1B, CSF1, LTA
89.2IL1R1, IL1B, LTA
99.2IL1A, IL1B, MYB
109.1CSF1, IL1A, IL1B
119.1IL1B, IL1A, CSF1
12
Show member pathways
9.1LTA, IL1A, IL1B
139.1LTA, IL1A, IL1B
14
Show member pathways
Immune response MIF in innate immunity response60
9.1IL1A, IL1B, IL1R1
15
Show member pathways
9.1IL1R1, IL1B, IL1A
16
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.1IL1A, IL1B, IL1R1
17
Show member pathways
9.1IL1A, IL1B, IL1R1
189.1IL1A, IL1B, IL1R1
19
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
9.1IL1R1, IL1B, IL1A
20
Show member pathways
9.1IL1A, IL1B, IL1R1
219.0IL1B, CSF1, CD68
22
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
23
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
8.7IL1R1, IL1B, IL1A, LTA
24
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
25
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
26
Show member pathways
thioredoxin pathway37
8.7F2, SERPINA3, IL1B, CRP
278.5IL1R1, IL1B, IL1A, CSF1R, CSF1
288.1CSF1, TFRC, IL1R1, IL1B, IL1A, CSF1R
29
Show member pathways
8.1F2, IL1R1, IL1B, IL1A, CSF1R, LTA
30
Show member pathways
7.4TNFRSF8, IL1R1, IL1B, IL1A, CSF1R, CSF1
31
Show member pathways
7.4TNFRSF8, IL1R1, IL1B, IL1A, CSF1R, CSF1
32
Show member pathways
7.4CSF1, CSF1R, IL1A, IL1B, IL1R1, TNFRSF8
33
Show member pathways
7.0F2, TNFRSF8, IL1R1, IL1B, IL1A, CSF1R

Compounds for genes affiliated with Malignant Histiocytosis

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Compounds related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1methylcellulose449.4MYB, IL1A, TFRC, CSF1
24-ipp619.3IL1A, IL1B, IL1R1
3anakinra44 1110.2CRP, IL1B, IL1R1
4gm-csf44 2810.2CSF1, CSF1R, IL1A, IL1B
5git 27619.2IL1B, IL1A, IL1R1
6gold sodium thiomalate449.1IL1R1, IL1B, IL1A
7ionomycin449.1LTA, IL1A, SERPINA3, TFRC, CSF1
8pirfenidone44 6110.1IL1R1, IL1B, IL1A
9pentoxifylline44 1110.0IL1R1, IL1A, LTA, IL1B
10infliximab44 50 1111.0LTA, CRP, IL1B, IL1R1
11tenidap44 2810.0IL1B, IL1R1, IL1A, CRP
1212-o-tetradecanoylphorbol 13-acetate449.0IL1A, CSF1R, MYB, CSF1, IL1R1, LTA
13il 10448.9LTA, CSF1, IL1R1, IL1B, IL1A
14fmlp448.9IL1B, SERPINA3, LTA, CSF1, IL1A
15hydroxyurea44 50 1110.9F2, CSF1, TFRC, IL1A
16etanercept44 50 1110.8LTA, CRP, CSF1, IL1R1, IL1B
17polyethylene glycol448.8CRP, IL1A, IL1R1, TFRC, F2
18vitamin d448.7TFRC, IL1A, CSF1R, LTA, IL1R1
19progesterone44 28 61 24 1112.7LTA, MYB, IL1R1, SERPINA3, IL1A, CSF1R
20sulfasalazine28 44 50 1111.7CSF1, IL1B, IL1A, CRP, IL1R1
21hyaluronic acid44 249.7IL1R1, IL1B, IL1A, LTA, F2
22ascorbic acid44 249.7CSF1, IL1A, IL1R1, TFRC, CRP
23rantes448.7IL1B, IL1A, IL1R1, LTA, CSF1
24acetylcholine44 50 28 24 1112.6SERPINA3, LTA, CRP, TFRC, IL1A, CSF1
25rapamycin448.6CSF1, TFRC, MYB, IL1R1, IL1A, CRP
26h2o2448.6CSF1, IL1A, TFRC, MYB, IL1R1, LTA
27methotrexate50 44 1110.6F2, IL1R1, IL1B, SERPINA3, CRP
28aspirin44 50 28 2411.6CSF1, IL1R1, CRP, F2, IL1B
29endotoxin448.6IL1R1, CRP, IL1B, IL1A, LTA
30lactate448.5CRP, CSF1, IL1R1, F2, TFRC, LTA
31leukotriene b444 61 2410.5IL1A, IL1B, IL1R1, CSF1
32indomethacin44 28 61 1111.5TFRC, IL1B, IL1A, CSF1, LTA, IL1R1
33calcitriol44 61 24 1111.4F2, IL1A, TFRC, LTA, CSF1, IL1B
34ivig448.4CRP, LTA, IL1R1, IL1B, IL1A, CSF1
35estrogen448.4F2, TFRC, SERPINA3, LTA, MYB, IL1R1
36alanine448.3MYB, IL1R1, F2, TFRC, SERPINA3, CSF1
37n acetylcysteine448.3F2, TFRC, IL1R1, IL1B, CSF1, CRP
38actinomycin d448.2IL1B, TFRC, MYB, LTA, CSF1, IL1R1
39pge2448.2IL1B, CSF1, CSF1R, TFRC, LTA, IL1A
40neopterin448.0LTA, IL1R1, IL1B, IL1A, CSF1, CRP
41creatinine448.0F2, TFRC, SERPINA3, IL1R1, CRP, PDLIM3
42cyclosporin a44 28 619.9TNFRSF8, F2, TFRC, MYB, IL1R1, IL1A
43dexamethasone44 50 28 1110.8IL1A, CSF1R, CSF1, MYB, SERPINA3, TFRC
44retinoic acid44 248.7TFRC, SERPINA3, IL1R1, IL1B, MYB, IL1A
45thymidine44 248.7TFRC, IL1A, TNFRSF8, MYB, IL1R1, IL1B
46paraffin447.7LTA, CD68, CSF1R, IL1R1, SERPINA3, TNFRSF8
47lipid447.5LTA, TNFRSF8, CSF1R, SERPINA3, CD68, CRP
48cycloheximide447.5IL1R1, IL1B, TFRC, IL1A, CSF1R, CSF1
49vegf447.5IL1B, TFRC, MYB, IL1R1, IL1A, LTA
50serine447.1IL1R1, IL1A, LTA, CSF1, CSF1R, MYB

GO Terms for genes affiliated with Malignant Histiocytosis

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Cellular components related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.1SERPINA3, TFRC, F2
2membraneGO:0160208.5TFRC, IL1R1, CSF1, CD68, LTA
3extracellular spaceGO:0056157.6LTA, F2, TFRC, IL1B, IL1A, CSF1
4extracellular regionGO:0055767.5F2, TFRC, SERPINA3, IL1R1, IL1B, IL1A
5plasma membraneGO:0058867.5TFRC, TNFRSF8, IL1R1, CSF1R, CSF1, CD68

Biological processes related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1macrophage differentiationGO:03022510.1CSF1, CSF1R
2osteoclast differentiationGO:0303169.8TFRC, CSF1R, CSF1
3fever generationGO:0016609.6IL1A, IL1B
4defense response to Gram-positive bacteriumGO:0508309.6LTA, CRP
5ectopic germ cell programmed cell deathGO:0352349.6IL1A, IL1B
6positive regulation of interleukin-2 biosynthetic processGO:0450869.6IL1A, IL1B
7acute-phase responseGO:0069539.5CRP, SERPINA3, F2
8positive regulation vascular endothelial growth factor productionGO:0105759.5IL1A, IL1B
9cellular response to organic substanceGO:0713109.4IL1B, CD68
10positive regulation of mitosisGO:0458409.4IL1B, IL1A
11positive regulation of protein phosphorylationGO:0019349.4F2, IL1B, CSF1R
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012409.1IL1A, IL1B
13cytokine-mediated signaling pathwayGO:0192219.0CSF1R, IL1A, IL1B
14inflammatory responseGO:0069548.4CRP, CSF1, CSF1R, IL1A, IL1B, SERPINA3

Molecular functions related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.4IL1A, IL1B
2cytokine activityGO:0051258.5LTA, CSF1, IL1A, IL1B

Products for genes affiliated with Malignant Histiocytosis

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Sources for Malignant Histiocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet