MCID: MLG054
MIFTS: 60

Malignant Histiocytosis malady

Summaries for Malignant Histiocytosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary... more...

MalaCards: Malignant Histiocytosis, also known as histiocytic medullary reticulosis, is related to histiocytosis and leukemia. An important gene associated with Malignant Histiocytosis is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are TGF-Beta Pathway and Transcription NF-kB signaling pathway. The compounds gm-csf and p003 have been mentioned in the context of this disorder. Affiliated tissues include spleen, lymph node and liver, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Malignant Histiocytosis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 22GTR, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

malignant histiocytosis 8 10 44 60
histiocytic medullary reticulosis 8 22 60
malignant midline reticulosis 8
malignant reticulosis 8
stewart's granuloma 8


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Disease Ontology8 DOID:8580
MeSH34 D054747
ICD9CM27 202.3
NCIt39 C7202

Related Diseases for Malignant Histiocytosis

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17GeneCards, 18GeneDecks
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Diseases in the Histiocytosis family:

malignant histiocytosis

Diseases related to Malignant Histiocytosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis31.8CD68
2leukemia30.8CSF1R, CSF1, TFRC, MYB, LTA, IL1R1
3acute leukemia30.6PTPRC, MYB, TFRC, CSF1, CSF1R
4mediastinitis30.4CRP
5sarcoma30.4CSF1R, CSF1, IL1R1, PTPRC
6anaplastic large cell lymphoma30.3PTPRC, TNFRSF8, CSF1R
7hepatitis30.3SERPINA1, F2, LTA, TFRC
8t-cell leukemia30.2TNFRSF8, TFRC, MYB, LTA, IL1A, PTPRC
9lupus erythematosus30.1F2
10malaria30.1TFRC, SERPINA3
11chronic lymphocytic leukemia30.1PTPRC, LTA, MYB, TFRC
12meningitis30.1IL1B, CRP
13hodgkin's lymphoma30.1CSF1R, TNFRSF8, LTA, CD68, PTPRC
14arthritis30.1IL1A, IL1B, SERPINA1
15systemic lupus erythematosus30.1PTPRC, F2, IL1R1, LTA, CRP
16rheumatoid arthritis30.1TNFRSF8, CSF1, TFRC, CRP, MYB, SERPINA3
17polycythemia29.9TFRC
18crohn's disease29.9CRP
19disseminated intravascular coagulation29.9F2
20acquired immunodeficiency syndrome29.9IL1B
21letterer-siwe disease29.9CSF1, CD68
22uveitis29.9LTA, IL1R1, IL1A
23vasculitis29.9CRP, F2, SERPINA1
24monocytic leukemia29.9CSF1, IL1R1, IL1B
25thrombocytopenia29.9CSF1, MYB, IL1R1, IL1A, F2
26myeloid leukemia29.9CSF1R, CSF1, TFRC, MYB, LTA, PTPRC
27respiratory failure29.9SERPINA1, IL1B, CRP
28pneumonia29.9SERPINA1, IL1B, CRP
29omenn syndrome10.3
30splenic infarction10.3
31lymphopenia10.3
32virus associated hemophagocytic syndrome10.3
33lethal midline granuloma10.3
34hepatitis a10.2
35acute lymphocytic leukemia10.2
36eosinophilia10.2
37leishmaniasis10.2
38malignant histiocytic disease10.1
39adult respiratory distress syndrome10.1
40fibrous histiocytoma10.1
41visceral leishmaniasis10.1
42acute t cell leukemia10.1
43myeloid sarcoma10.1
44adult syndrome10.1
45histiocytoma10.1
46intestinal disease10.1
47malignant teratoma10.1
48panniculitis10.1
49parapsoriasis10.1
50dementia10.0SERPINA3

Graphical network of the top 20 diseases related to Malignant Histiocytosis:



Diseases related to malignant histiocytosis

Clinical Features for Malignant Histiocytosis

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Drugs & Therapeutics for Malignant Histiocytosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Malignant Histiocytosis

Drug clinical trials:

Search ClinicalTrials for Malignant Histiocytosis

Search NIH Clinical Center for Malignant Histiocytosis

Search CenterWatch for Malignant Histiocytosis

Genetic Tests for Malignant Histiocytosis

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22GTR
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Genetic tests related to Malignant Histiocytosis:

id Genetic test Affiliating Genes
1 Histiocytic Medullary Reticulosis22

Anatomical Context for Malignant Histiocytosis

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32MalaCards
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MalaCards organs/tissues related to Malignant Histiocytosis:

32
Spleen, Lymph node, Liver, Lung, Bone marrow, Bone, T cells, Skin, Brain, B cells, Monocytes, Myeloid, Small intestine, Thyroid, Pancreas, Colon, Spinal cord

Animal Models for Malignant Histiocytosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Histiocytosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.5PTPRC, IL1R1, LTA
2MP:00107719.3CSF1R, MYB, IL1R1, F2
3MP:00053708.5UCHL1, CSF1, TFRC, MYB, LTA, IL1R1
4MP:00053908.4CSF1R, CSF1, LTA, CD68, IL1B, PTPRC
5MP:00053787.6UCHL1, CSF1R, CSF1, TFRC, MYB, LTA
6MP:00107687.0UCHL1, PDLIM3, CSF1R, CSF1, TFRC, MYB
7MP:00053856.8UCHL1, PDLIM3, CSF1, TFRC, CRP, MYB
8MP:00053766.7PDLIM3, CSF1R, CSF1, TFRC, CRP, LTA
9MP:00053976.3TFRC, TNFRSF8, CSF1, CSF1R, UCHL1, MYB
10MP:00053875.5PTPRC, CSF1R, CSF1, TNFRSF8, TFRC, CRP

Publications for Malignant Histiocytosis

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50PubMed
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Articles related to Malignant Histiocytosis:

(show top 50)    (show all 361)
idTitleAuthorsYear
1
Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. (22236140)
2012
2
Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis). (21617208)
2011
3
Langerhans cell histiocytosis: malignancy or inflammatory disorder doing a great job of imitating one? (19726802)
2009
4
Cytokine genes single nucleotide polymorphism (SNP) screening analyses in canine malignant histiocytosis. (17094461)
2006
5
Langerhans cell histiocytosis after therapy for a malignant germ cell tumor of the central nervous system. (10959908)
2000
6
Blast crisis of Ph1-CML, with the prevalent features of malignant histiocytosis. (9549930)
1998
7
Malignant histiocytosis in a Bernese mountain dog presenting as a mandibular mass. (9028594)
1997
8
Malignant histiocytosis. (7603401)
1995
9
Malignant histiocytosis in a patient presenting with hepatic dysfunction and peliosis hepatis. (7872292)
1995
10
Epstein-Barr virus-containing T-cell lymphoma presents with hemophagocytic syndrome mimicking malignant histiocytosis. (8395969)
1993
11
Visceral leishmaniasis with a very-low degree of bone-marrow parasitemia, mimicking malignant histiocytosis. (21573388)
1993
12
Modulation of c-myc, c-myb, c-fos, c-sis and c-fms proto-oncogene expression and of CSF-1 transcripts and protein by phorbol diester in human malignant histiocytosis DEL cell line with 5q 35 break point. (8352523)
1993
13
Malignant histiocytosis in a patient with chronic active Epstein-Barr virus infection. (1359251)
1992
14
Malignant histiocytosis of the intestine simulating Crohn's disease. Report of a case. (1740074)
1992
15
Analysis of spleen cells in malignant histiocytosis in infancy. (20394564)
1990
16
Malignant histiocytosis with panniculitis--a case report. (2229645)
1990
17
An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis. (2670186)
1989
18
The cytology of malignant histiocytosis (sinusoidal hematolymphoid malignancy). (2781972)
1989
19
Changes in intraepithelial lymphocyte subpopulations in coeliac disease and enteropathy associated T cell lymphoma (malignant histiocytosis of the intestine). (2785074)
1989
20
A novel translocation, t(2;5)(p23;q35), in childhood phagocytic large T-cell lymphoma mimicking malignant histiocytosis. (2537120)
1989
21
EBM/11 reactivity in malignant histiocytosis. (3225331)
1988
22
High serum ferritin level as a marker of malignant histiocytosis and virus-associated hemophagocytic syndrome. (3359404)
1988
23
Cytogenetic analysis of a child with malignant histiocytosis. (3476192)
1987
24
Chromosomal and fluorometric DNA analyses of malignant histiocytosis. (3811786)
1986
25
Malignant histiocytosis in Bernese Mountain dogs. (3710888)
1986
26
Chromosomal changes in a documented case of malignant histiocytosis: significance of polyploidy. (3510716)
1986
27
Chromosome 5q35 breakpoint in malignant histiocytosis. (3702936)
1986
28
Malignant histiocytosis: case report and review. (3977614)
1985
29
Bone marrow transplantation for malignant histiocytosis in childhood. (3902201)
1985
30
Large granular lymphocyte leukemia in F344 rats. Model for human T gamma lymphoma, malignant histiocytosis, and T-cell chronic lymphocytic leukemia. (3874555)
1985
31
Malignant histiocytosis resistant to anthracycline. Response to intensive treatment with etoposide and amsacrine. (3872645)
1985
32
Rheumatoid arthritis and malignant histiocytosis of the intestine. (6497470)
1984
33
Malignant histiocytosis X. Report of a rapidly fatal case in an elderly man. (6202393)
1984
34
A case of malignant histiocytosis. (6709311)
1984
35
Malignant histiocytosis in the oropharynx. (6471863)
1984
36
Malignant histiocytosis with unusual features. Disseminated intravascular coagulation with severe hyperfibrinolysis, acute polyneuroradiculitis Guillain-BarrAc, and a unique chromosome abnormality. (6697295)
1984
37
Malignant histiocytosis. Clinical and cytogenetic studies in a newborn and a child. (6883287)
1983
38
Cutaneous malignant histiocytosis: a clinical and histopathologic study of eight cases, with immunohistochemical analysis. (6826808)
1983
39
Malignant histiocytosis after lymphoblastic lymphoma. (6687781)
1983
40
Oral manifestations of malignant histiocytosis (histiocytic medullary reticulosis). (6956837)
1982
41
Malignant lymphoma in the nose. Clinicopathological differences from the malignant histiocytosis presenting as lethal midline granuloma. (7312704)
1981
42
Cutaneous involvement of malignant lymphoma and malignant histiocytosis. (7037895)
1981
43
Polymyositis associated with malignant histiocytosis. (7265402)
1981
44
Malignant histiocytosis. Immunohistochemical characterization on paraffin embedded tissue. (7355572)
1980
45
Cytological and functional characterization of three cases of malignant histiocytosis. (7427882)
1980
46
'Lennert's lymphoma' terminating as malignant histiocytosis. (542804)
1979
47
The cytomorphological diagnosis of malignant histiocytosis. (741526)
1978
48
T cell acute lymphocytic leukemia terminating as malignant histiocytosis. (306197)
1978
49
Blindness in a patient with malignant histiocytosis. (851952)
1977
50
Malignant histiocytosis: complete remission with combination chemotherapy. (953957)
1976

Genetic Variations for Malignant Histiocytosis

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Expression for genes affiliated with Malignant Histiocytosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Histiocytosis

Search GEO for disease gene expression data for Malignant Histiocytosis.

Pathways for genes affiliated with Malignant Histiocytosis

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51QIAGEN, 12EMD Millipore, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 59Tocris Bioscience
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Pathways related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.6CSF1R, LTA, F2
29.5IL1A, IL1R1, LTA
39.4IL1A, IL1B
49.4CSF1, LTA, IL1B
59.3LTA, IL1R1, IL1B
69.1IL1B, IL1A, LTA
7
Hide members
9.1IL1R1, IL1A, IL1B
8
Immune response Bacterial infections in normal airways
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9.1IL1B, IL1A, IL1R1
9
Hide members
9.1IL1B, IL1A, IL1R1
10
Hide members
9.1IL1R1, IL1A, IL1B
11
Hide members
9.1IL1R1, IL1A, IL1B
12
Hide members
9.1IL1B, IL1A, IL1R1
139.1IL1B, IL1A, IL1R1
149.1IL1B, CD68, CSF1
15
Hide members
8.8LTA, IL1R1, IL1A, IL1B
16
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8.8LTA, IL1R1, IL1A, IL1B
17
Hide members
8.8IL1A, TNFRSF8, CSF1, CSF1R
188.7CRP, IL1B, F2, SERPINA3
19
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8.7PTPRC, IL1B, IL1A, IL1R1
208.7CSF1R, CSF1, IL1R1, IL1A, IL1B
218.4IL1B, IL1A, IL1R1, TFRC, CSF1, CSF1R
22
Hide members
8.3CSF1R, CSF1, TNFRSF8, LTA, IL1R1, PTPRC
23
Hide members
8.0TNFRSF8, LTA, IL1R1, IL1A, IL1B
24
Hide members
7.6CSF1R, CSF1, TNFRSF8, LTA, IL1R1, IL1A
25
Hide members
7.6CSF1R, CSF1, TNFRSF8, LTA, IL1R1, IL1A

Compounds for genes affiliated with Malignant Histiocytosis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.6CSF1R
2p0034410.6CSF1
3indomethacin44 59 28 1113.3CSF1, IL1R1
4tenidap44 2811.2IL1R1, IL1A
5pentoxifylline44 1111.1IL1R1, LTA
6cycloheximide4410.1LTA, CSF1R, TFRC
7acetylcholine44 49 28 11 2414.0TFRC, LTA, SERPINA3
8h2o2449.7PTPRC, IL1R1, LTA, MYB
9methylcellulose449.6CSF1, TFRC, MYB, IL1A
10fmlp449.6PTPRC, SERPINA3, CSF1, IL1A
11dexamethasone44 49 28 1112.5CSF1R, PTPRC, MYB, LTA, IL1R1
12dmso449.3PTPRC, CSF1R, MYB, TFRC, CSF1
13vitamin a44 11 2411.3SERPINA3, SERPINA1, IL1A, TFRC
14anakinra44 1110.3CRP, IL1R1, IL1B
15git 27599.2IL1R1, IL1B, IL1A
164-ipp599.2IL1B, IL1A, IL1R1
17iron44 2410.1SERPINA3, SERPINA1, IL1R1, TFRC, MYB
18methionine449.1SERPINA3, IL1R1, MYB, CSF1R, PTPRC, SERPINA1
19infliximab44 49 1111.0IL1R1, IL1B, CRP, LTA
20il 10449.0IL1B, IL1R1, LTA, IL1A, CSF1
21ionomycin449.0PTPRC, CSF1, LTA, IL1A, SERPINA3, TFRC
22etanercept44 49 1111.0LTA, CRP, IL1R1, CSF1, IL1B
23serine448.9CSF1, CSF1R, UCHL1, IL1A, IL1R1, SERPINA3
24polyethylene glycol448.9TFRC, CRP, IL1R1, F2, IL1A
25heparin44 28 11 2411.9IL1R1, CSF1, PTPRC, SERPINA1, IL1A, SERPINA3
26sulfasalazine44 28 49 1111.8IL1R1, CRP, CSF1, IL1A, IL1B
27rapamycin448.8TFRC, CRP, CSF1, IL1R1, IL1A, MYB
28herbimycin a44 599.7IL1A, IL1B, LTA, TFRC, PTPRC
29ascorbic acid44 249.7IL1R1, SERPINA1, CRP, CSF1, IL1A, TFRC
30calcitriol44 59 11 2411.6IL1A, F2, IL1B, LTA, TFRC, CSF1
31cyclosporin a44 28 5910.5PTPRC, F2, IL1R1, LTA, TNFRSF8, MYB
32ivig448.5IL1B, IL1R1, CRP, LTA, IL1A, CSF1
33acth448.5IL1A, IL1R1, SERPINA1, IL1B, PTPRC
3412-o-tetradecanoylphorbol 13-acetate448.5IL1R1, IL1A, PTPRC, LTA, UCHL1, MYB
35creatinine448.5PDLIM3, F2, CRP, IL1A, SERPINA1, SERPINA3
36actinomycin d448.5TFRC, LTA, IL1R1, IL1A, IL1B, MYB
37lactate448.5CRP, IL1R1, LTA, CSF1, TFRC, F2
38hyaluronic acid44 249.5IL1A, PTPRC, F2, LTA, IL1R1, IL1B
39aspirin44 49 28 2411.3F2, IL1B, IL1R1, CRP, CSF1
40cysteine448.3PTPRC, SERPINA1, MYB, SERPINA3, IL1R1, UCHL1
41progesterone44 59 28 11 2412.3PTPRC, IL1R1, LTA, MYB, CSF1, CSF1R
42neopterin448.2TFRC, IL1B, IL1A, IL1R1, CRP, CSF1
43methotrexate44 49 1110.2IL1R1, F2, SERPINA3, IL1B, CRP
44n acetylcysteine448.2F2, PTPRC, IL1R1, CRP, TFRC, CSF1
45retinoic acid44 249.1IL1A, IL1R1, LTA, MYB, TFRC, CSF1
46vegf447.8IL1A, IL1B, LTA, MYB, IL1R1, TFRC
47thymidine44 248.6IL1R1, IL1B, SERPINA1, MYB, TFRC, IL1A
48tyrosine447.4TNFRSF8, MYB, IL1R1, CSF1R, LTA, TFRC
49paraffin447.3TNFRSF8, CD68, SERPINA1, SERPINA3, PTPRC, LTA
50lipid447.1IL1R1, LTA, CD68, SERPINA3, SERPINA1, PTPRC

GO Terms for genes affiliated with Malignant Histiocytosis

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16Gene Ontology
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Cellular components related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.3SERPINA3, CSF1, CRP, LTA, IL1A, IL1B
2extracellular regionGO:0055767.1TFRC, CRP, IL1R1, IL1A, IL1B, F2
3plasma membraneGO:0058866.5CSF1R, CSF1, TNFRSF8, TFRC, CRP, CD68

Biological processes related to Malignant Histiocytosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1osteoclast differentiationGO:0303169.9TFRC, CSF1, CSF1R
2macrophage differentiationGO:0302259.7CSF1, CSF1R
3response to lead ionGO:0102889.7SERPINA1, CRP
4fever generationGO:0016609.5IL1A, IL1B
5positive regulation of interleukin-2 biosynthetic processGO:0450869.3IL1A, IL1B
6positive regulation of protein phosphorylationGO:0019349.3F2, IL1B, CSF1R
7cell proliferationGO:0082839.3IL1A, CSF1, CSF1R, UCHL1
8acute-phase responseGO:0069539.2SERPINA3, SERPINA1, F2, CRP
9inflammatory responseGO:0069548.4CSF1R, CSF1, CRP, IL1A, IL1B, SERPINA3

Molecular functions related to Malignant Histiocytosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.4IL1B, IL1A
2cytokine activityGO:0051258.6IL1B, IL1A, LTA, CSF1

Products for genes affiliated with Malignant Histiocytosis

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Sources for Malignant Histiocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet