MCID: MLG054
MIFTS: 55

Malignant Histiocytosis malady

Cancer diseases, Immune diseases, Rare diseases categories

Summaries for Malignant Histiocytosis

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Wikipedia:63 Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary... more...

MalaCards based summary: Malignant Histiocytosis, also known as histiocytic medullary reticulosis, is related to histiocytosis and myelodysplastic syndrome. An important gene associated with Malignant Histiocytosis is MYB (v-myb avian myeloblastosis viral oncogene homolog), and among its related pathways are TRAF Pathway and Signaling events mediated by TCPTP. The compounds methylcellulose and 4-ipp have been mentioned in the context of this disorder. Affiliated tissues include t cells, spleen and lymph node, and related mouse phenotypes are liver/biliary system and integument.

Aliases & Classifications for Malignant Histiocytosis

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 22GTR, 55SNOMED-CT, 38NCIt, 27ICD9CM, 33MeSH, 25ICD10
See all sources

Malignant Histiocytosis, Aliases & Descriptions:

Name: Malignant Histiocytosis 9 11 43 60
Histiocytic Medullary Reticulosis 9 22
Nasal Type Extranodal Nk/t-Cell Lymphoma 60
 
Malignant Midline Reticulosis 9
Malignant Reticulosis 9
Stewart's Granuloma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Immune diseases


External Ids:

Disease Ontology9 DOID:8580
NCIt38 C7202
ICD9CM27 202.3
MeSH33 D054747
ICD1025 C86.0

Related Diseases for Malignant Histiocytosis

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Diseases in the Histiocytosis family:

malignant histiocytosis

Diseases related to Malignant Histiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1histiocytosis32.8CD68
2myelodysplastic syndrome30.7CSF1, CSF1R
3acute myelomonocytic leukemia30.7CSF1, CSF1R
4chronic myelomonocytic leukemia30.6CSF1R, CSF1
5chronic lymphocytic leukemia30.5LTA, TFRC, MYB
6arthritis30.4IL1A, IL1B
7hepatitis30.4F2, TFRC, LTA
8malaria30.3IL1R1, IL1B, IL1A
9monocytic leukemia30.2CSF1, IL1B, IL1R1
10acute leukemia30.2MYB, CSF1R, CSF1, TFRC
11uveitis30.1LTA, IL1A, IL1R1
12systemic lupus erythematosus29.9CRP, F2, LTA, IL1R1
13t-cell leukemia29.8LTA, TFRC, MYB, IL1A, TNFRSF8
14leukemia29.7TFRC, MYB, IL1R1, CSF1, IL1B, LTA
15thrombocytopenia29.7MYB, IL1R1, F2, CSF1, IL1A
16respiratory failure29.6IL1B, CRP
17rheumatoid arthritis28.3LTA, CD68, CSF1, IL1A, IL1B, MYB
18multicentric reticulohistiocytosis10.5CD68
19lymphosarcoma10.5TNFRSF8
20virus associated hemophagocytic syndrome10.5
21schnitzler syndrome10.5IL1R1
22pigmented villonodular synovitis10.4CSF1R, CSF1
23blau syndrome10.4IL1B
24intervertebral disc disease10.4IL1B
25giant cell tumor10.4CSF1R, CSF1
26langerhans-cell histiocytosis10.4CD68, CSF1
27systemic onset juvenile idiopathic arthritis10.4IL1R1, SERPINA3
28mediastinitis10.4
29sarcoma10.4
30b-cell lymphomas10.3
31lethal midline granuloma10.3
32adult-onset still's disease10.3CRP
33malignant fibroxanthoma10.3TNFRSF8, SERPINA3, CD68
34muckle-wells syndrome10.3IL1R1, IL1B
35refractory anemia10.3TFRC, CSF1
36hematologic cancer10.3CSF1R, TNFRSF8, CSF1
37lymphoblastic lymphoma10.3
38eosinophilia10.3
39leishmaniasis10.3
40acute graft versus host disease10.3LTA, IL1R1
41familial cold autoinflammatory syndrome10.3IL1B, IL1R1
42peripheral t-cell lymphoma10.2TNFRSF8, LTA
43cinca syndrome10.2IL1R1, IL1B
44cutaneous t cell lymphoma10.2MYB, TFRC, TNFRSF8
45secondary syphilis10.2CSF1, PDLIM3, LTA
46idiopathic myopathy10.2IL1A, IL1R1
47alopecia areata10.2IL1R1, IL1A
48reticulosarcoma10.2CD68, TNFRSF8
49periodontitis10.2IL1A, IL1B
50polymyalgia rheumatica10.2CRP, SERPINA3

Graphical network of the top 20 diseases related to Malignant Histiocytosis:



Diseases related to malignant histiocytosis

Symptoms for Malignant Histiocytosis

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Drugs & Therapeutics for Malignant Histiocytosis

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Drug clinical trials:

Search ClinicalTrials for Malignant Histiocytosis

Search NIH Clinical Center for Malignant Histiocytosis

Genetic Tests for Malignant Histiocytosis

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Genetic tests related to Malignant Histiocytosis:

id Genetic test Affiliating Genes
1 Histiocytic Medullary Reticulosis22

Anatomical Context for Malignant Histiocytosis

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MalaCards organs/tissues related to Malignant Histiocytosis:

31
T cells, Spleen, Lymph node, Liver, Lung, Bone marrow, Bone, Brain, Skin, B cells, Myeloid, Monocytes, Small intestine, Spinal cord, Colon, Pancreas, Thyroid, Neutrophil

Animal Models for Malignant Histiocytosis or affiliated genes

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MGI Mouse Phenotypes related to Malignant Histiocytosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6MYB, IL1R1, CSF1, LTA, TFRC
2MP:00107718.5TFRC, CSF1, MYB, CSF1R, F2, IL1R1
3MP:00053788.2IL1R1, F2, TFRC, MYB, CSF1R, CSF1
4MP:00053907.8F2, CD68, CSF1, CSF1R, IL1B, LTA
5MP:00107687.3CSF1, F2, TFRC, IL1B, CSF1R, PDLIM3
6MP:00053856.7LTA, F2, TFRC, PDLIM3, CRP, CSF1
7MP:00053766.7TFRC, IL1R1, IL1B, CSF1R, CSF1, PDLIM3
8MP:00053976.0CD68, LTA, F2, TFRC, TNFRSF8, MYB
9MP:00053875.5F2, LTA, TNFRSF8, MYB, IL1B, CD68

Publications for Malignant Histiocytosis

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Articles related to Malignant Histiocytosis:

(show top 50)    (show all 348)
idTitleAuthorsYear
1
Establishment of a new canine cell line (CCT) originated from a cutaneous malignant histiocytosis. (12867736)
2003
2
Malignant histiocytosis. (11138619)
2001
3
Malignant histiocytosis in cattle. (11193337)
2000
4
An Asian variant of intravascular lymphomatosis: an updated review of malignant histiocytosis-like B-cell lymphoma. (10342574)
1999
5
True malignant histiocytosis developed during chemotherapy for mediastinal immature teratoma. (8892599)
1996
6
Malignant histiocytosis in childhood: a disease in quest of new nosological criteria. (7603402)
1995
7
Malignant histiocytosis in the leukaemic stage: a new entity (M5c-AML) in the FAB classification? (8127155)
1994
8
Etoposide-based combination chemotherapy in malignant histiocytosis. (7760434)
1994
9
Clinical and radiographic manifestations of canine malignant histiocytosis. (8266626)
1993
10
Malignant histiocytosis in childhood: a distinctive CD30-positive clinicopathological entity associated with a chromosomal translocation involving 5q35. (1313990)
1992
11
The unique association of malignant histiocytosis and a primary gonadal germ cell tumor. (1734222)
1992
12
Phenytoin-induced hemocytophagic histiocytosis indistinguishable from malignant histiocytosis. (2035091)
1991
13
Malignant histiocytosis presenting as erythroderma. (2139870)
1990
14
Distribution of three proteinases in tumor cells of malignant histiocytosis]. (2279308)
1990
15
Analysis of spleen cells in malignant histiocytosis in infancy. (20394564)
1990
16
An immunocytochemical study on the distribution of ferritin and other markers in 36 cases of malignant histiocytosis. (2670186)
1989
17
Malignant histiocytosis: a specific t(2;5)(p23;q35) translocation? Review of the literature. (3416066)
1988
18
Malignant histiocytosis. Clinicopathologic review of 18 cases with immunohistochemical study. (3267356)
1988
19
Malignant histiocytosis. (3065384)
1988
20
Enteropathy-associated T cell lymphoma (malignant histiocytosis of the intestine) is recognized by a monoclonal antibody (HML-1) that defines a membrane molecule on human mucosal lymphocytes. (3260750)
1988
21
Chronic myelomonocytic leukemia terminating as malignant histiocytosis. (3334348)
1987
22
Malignant histiocytosis complicating rheumatoid arthritis: report of four cases. (3950028)
1986
23
Chromosomal and fluorometric DNA analyses of malignant histiocytosis. (3811786)
1986
24
Malignant histiocytosis in Bernese Mountain dogs. (3710888)
1986
25
Immunophenotype analysis of malignant histiocytosis of the intestine. (3512610)
1986
26
Immature phenotypic conversion in a patient with malignant histiocytosis. (3766080)
1986
27
Fatal disseminated adenovirus infection featuring liver necrosis and prolonged viremia in an immunosuppressed child with malignant histiocytosis. (2994509)
1985
28
Malignant histiocytosis: report of three cases. (3831202)
1985
29
Malignant histiocytosis: case report and review. (3977614)
1985
30
Erythema annulare centrifugum and malignant histiocytosis--report of a case. (6499278)
1984
31
Malignant histiocytosis--a clinicopathologic study of 5 cases. (6549118)
1984
32
Malignant histiocytosis. Clinical and cytogenetic studies in a newborn and a child. (6883287)
1983
33
Malignant histiocytosis in childhood: morphologic considerations. (6642496)
1983
34
Cutaneous malignant histiocytosis: a clinical and histopathologic study of eight cases, with immunohistochemical analysis. (6826808)
1983
35
Non-B, non-T acute lymphoblastic leukaemia terminating in malignant histiocytosis: a new case and a review of the literature. (6293942)
1982
36
Malignant histiocytosis with slow clinical course. (7134061)
1982
37
Ichthyosis and marrow involvement in malignant histiocytosis of the intestine. (7236527)
1981
38
Malignant histiocytosis --- a case report. (7332304)
1981
39
Respiratory failure in malignant histiocytosis. (7305121)
1981
40
Pulmonary involvement of malignant histiocytosis: a clinicopathologic spectrum. (7246850)
1981
41
Malignant histiocytosis in childhood: clinical study and therapeutic results in 22 cases. (7379013)
1980
42
Malignant histiocytosis in children from the Eastern Mediterranean. (7453672)
1980
43
Null cell (non-T, non-B) acute lymphoblastic leukemia terminating as malignant histiocytosis. (6929651)
1980
44
Malignant histiocytosis associated with malabsorption. (262066)
1979
45
Virus-associated hemophagocytic syndrome: a benign histiocytic proliferation distinct from malignant histiocytosis. (225008)
1979
46
Cytomorphologic and cytochemical aspects of malignant histiocytosis with spindle-cell differentiation. A case report. (294074)
1979
47
Lymphoreticular neoplasia in a dog resembling malignant histiocytosis (histiocytic medullary reticulosis) in man. (467080)
1979
48
Sarcomatous variant of malignant histiocytosis; a case report and review of the literature. (735827)
1978
49
Malignant histiocytosis: complete remission with combination chemotherapy. (953957)
1976
50
Malignant histiocytosis with eosinophilia. (4757932)
1973

Variations for Malignant Histiocytosis

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Expression for genes affiliated with Malignant Histiocytosis

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Search GEO for disease gene expression data for Malignant Histiocytosis.

Pathways for genes affiliated with Malignant Histiocytosis

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Pathways related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.2LTA
29.9CSF1, CSF1R
39.7IL1R1, IL1A
4
Show member pathways
Serotonin Transporter Activity36
9.5IL1R1, IL1B
59.4IL1A, IL1B
69.4IL1A, IL1B
79.2IL1B, CSF1, LTA
89.2IL1R1, IL1B, LTA
99.2IL1A, IL1B, MYB
109.1CSF1, IL1A, IL1B
119.1IL1B, IL1A, CSF1
12
Show member pathways
9.1LTA, IL1A, IL1B
139.1LTA, IL1A, IL1B
14
Show member pathways
Immune response MIF in innate immunity response58
9.1IL1A, IL1B, IL1R1
15
Show member pathways
9.1IL1R1, IL1B, IL1A
16
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.1IL1A, IL1B, IL1R1
17
Show member pathways
9.1IL1A, IL1B, IL1R1
189.1IL1A, IL1B, IL1R1
19
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.1IL1R1, IL1B, IL1A
20
Show member pathways
9.1IL1A, IL1B, IL1R1
219.0IL1B, CSF1, CD68
22
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
23
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
8.7IL1R1, IL1B, IL1A, LTA
24
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
25
Show member pathways
8.7IL1R1, IL1B, IL1A, LTA
26
Show member pathways
thioredoxin pathway36
8.7F2, SERPINA3, IL1B, CRP
278.5IL1R1, IL1B, IL1A, CSF1R, CSF1
288.1CSF1, TFRC, IL1R1, IL1B, IL1A, CSF1R
29
Show member pathways
8.1F2, IL1R1, IL1B, IL1A, CSF1R, LTA
30
Show member pathways
7.4TNFRSF8, IL1R1, IL1B, IL1A, CSF1R, CSF1
31
Show member pathways
7.4TNFRSF8, IL1R1, IL1B, IL1A, CSF1R, CSF1
32
Show member pathways
7.4CSF1, CSF1R, IL1A, IL1B, IL1R1, TNFRSF8
33
Show member pathways
7.0F2, TNFRSF8, IL1R1, IL1B, IL1A, CSF1R

Compounds for genes affiliated with Malignant Histiocytosis

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Compounds related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 150)
idCompoundScoreTop Affiliating Genes
1methylcellulose439.4MYB, IL1A, TFRC, CSF1
24-ipp599.3IL1A, IL1B, IL1R1
3anakinra43 1210.2CRP, IL1B, IL1R1
4gm-csf43 2810.2CSF1, CSF1R, IL1A, IL1B
5git 27599.2IL1B, IL1A, IL1R1
6gold sodium thiomalate439.1IL1R1, IL1B, IL1A
7ionomycin439.1LTA, IL1A, SERPINA3, TFRC, CSF1
8pirfenidone43 5910.1IL1R1, IL1B, IL1A
9pentoxifylline43 1210.0IL1R1, IL1A, LTA, IL1B
10infliximab43 49 1211.0LTA, CRP, IL1B, IL1R1
11tenidap43 2810.0IL1B, IL1R1, IL1A, CRP
1212-o-tetradecanoylphorbol 13-acetate439.0IL1A, CSF1R, MYB, CSF1, IL1R1, LTA
13il 10438.9LTA, CSF1, IL1R1, IL1B, IL1A
14fmlp438.9IL1B, SERPINA3, LTA, CSF1, IL1A
15hydroxyurea43 49 1210.9F2, CSF1, TFRC, IL1A
16etanercept43 49 1210.8LTA, CRP, CSF1, IL1R1, IL1B
17polyethylene glycol438.8CRP, IL1A, IL1R1, TFRC, F2
18vitamin d438.7TFRC, IL1A, CSF1R, LTA, IL1R1
19progesterone43 28 59 24 1212.7LTA, MYB, IL1R1, SERPINA3, IL1A, CSF1R
20sulfasalazine28 43 49 1211.7CSF1, IL1B, IL1A, CRP, IL1R1
21hyaluronic acid43 249.7IL1R1, IL1B, IL1A, LTA, F2
22ascorbic acid43 249.7CSF1, IL1A, IL1R1, TFRC, CRP
23rantes438.7IL1B, IL1A, IL1R1, LTA, CSF1
24acetylcholine43 49 28 24 1212.6SERPINA3, LTA, CRP, TFRC, IL1A, CSF1
25rapamycin438.6CSF1, TFRC, MYB, IL1R1, IL1A, CRP
26h2o2438.6CSF1, IL1A, TFRC, MYB, IL1R1, LTA
27methotrexate49 43 1210.6F2, IL1R1, IL1B, SERPINA3, CRP
28aspirin43 49 28 2411.6CSF1, IL1R1, CRP, F2, IL1B
29endotoxin438.6IL1R1, CRP, IL1B, IL1A, LTA
30lactate438.5CRP, CSF1, IL1R1, F2, TFRC, LTA
31leukotriene b443 59 2410.5IL1A, IL1B, IL1R1, CSF1
32indomethacin43 28 59 1211.5TFRC, IL1B, IL1A, CSF1, LTA, IL1R1
33calcitriol43 59 24 1211.4F2, IL1A, TFRC, LTA, CSF1, IL1B
34ivig438.4CRP, LTA, IL1R1, IL1B, IL1A, CSF1
35estrogen438.4F2, TFRC, SERPINA3, LTA, MYB, IL1R1
36alanine438.3MYB, IL1R1, F2, TFRC, SERPINA3, CSF1
37n acetylcysteine438.3F2, TFRC, IL1R1, IL1B, CSF1, CRP
38actinomycin d438.2IL1B, TFRC, MYB, LTA, CSF1, IL1R1
39pge2438.2IL1B, CSF1, CSF1R, TFRC, LTA, IL1A
40neopterin438.0LTA, IL1R1, IL1B, IL1A, CSF1, CRP
41creatinine438.0F2, TFRC, SERPINA3, IL1R1, CRP, PDLIM3
42cyclosporin a43 28 599.9TNFRSF8, F2, TFRC, MYB, IL1R1, IL1A
43dexamethasone43 49 28 1210.8IL1A, CSF1R, CSF1, MYB, SERPINA3, TFRC
44retinoic acid43 248.7TFRC, SERPINA3, IL1R1, IL1B, MYB, IL1A
45thymidine43 248.7TFRC, IL1A, TNFRSF8, MYB, IL1R1, IL1B
46paraffin437.7LTA, CD68, CSF1R, IL1R1, SERPINA3, TNFRSF8
47lipid437.5LTA, TNFRSF8, CSF1R, SERPINA3, CD68, CRP
48cycloheximide437.5IL1R1, IL1B, TFRC, IL1A, CSF1R, CSF1
49vegf437.5IL1B, TFRC, MYB, IL1R1, IL1A, LTA
50serine437.1IL1R1, IL1A, LTA, CSF1, CSF1R, MYB

GO Terms for genes affiliated with Malignant Histiocytosis

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Cellular components related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.1SERPINA3, TFRC, F2
2membraneGO:00160208.5TFRC, IL1R1, CSF1, CD68, LTA
3extracellular spaceGO:00056157.6LTA, F2, TFRC, IL1B, IL1A, CSF1
4extracellular regionGO:00055767.5F2, TFRC, SERPINA3, IL1R1, IL1B, IL1A
5plasma membraneGO:00058867.5TFRC, TNFRSF8, IL1R1, CSF1R, CSF1, CD68

Biological processes related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1macrophage differentiationGO:003022510.1CSF1, CSF1R
2osteoclast differentiationGO:00303169.8TFRC, CSF1R, CSF1
3fever generationGO:00016609.6IL1A, IL1B
4defense response to Gram-positive bacteriumGO:00508309.6LTA, CRP
5ectopic germ cell programmed cell deathGO:00352349.6IL1A, IL1B
6positive regulation of interleukin-2 biosynthetic processGO:00450869.6IL1A, IL1B
7acute-phase responseGO:00069539.5CRP, SERPINA3, F2
8positive regulation vascular endothelial growth factor productionGO:00105759.5IL1A, IL1B
9cellular response to organic substanceGO:00713109.4IL1B, CD68
10positive regulation of mitosisGO:00458409.4IL1B, IL1A
11positive regulation of protein phosphorylationGO:00019349.4F2, IL1B, CSF1R
12negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:020012409.1IL1A, IL1B
13cytokine-mediated signaling pathwayGO:00192219.0CSF1R, IL1A, IL1B
14inflammatory responseGO:00069548.4CRP, CSF1, CSF1R, IL1A, IL1B, SERPINA3

Molecular functions related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.4IL1A, IL1B
2cytokine activityGO:00051258.5LTA, CSF1, IL1A, IL1B

Products for genes affiliated with Malignant Histiocytosis

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Sources for Malignant Histiocytosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet