MCID: MLG069
MIFTS: 54

Malignant Hypertension malady

Genetic diseases, Cardiovascular diseases, Blood diseases, Rare diseases categories

Aliases & Classifications for Malignant Hypertension

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Sources:
8Disease Ontology, 61UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT, 33MeSH
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Aliases & Descriptions for Malignant Hypertension:

Name: Malignant Hypertension 8 61
 
Hypertension Malignant 44


Classifications:



External Ids:

Disease Ontology8 DOID:10824
NCIt39 C3118
MeSH33 D006974

Summaries for Malignant Hypertension

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MalaCards based summary: Malignant Hypertension, also known as hypertension malignant, is related to purpura and thrombotic thrombocytopenic purpura. An important gene associated with Malignant Hypertension is ADM (adrenomedullin), and among its related pathways are Effects of PIP2 hydrolysis and TRP channels. The drugs captopril and enalapril and the compounds aliskiren and saralasin have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and liver, and related mouse phenotypes are muscle and renal/urinary system.

Related Diseases for Malignant Hypertension

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Diseases in the Familial Hypertension family:

Hypertension, Essential Benign Essential Hypertension
Malignant Essential Hypertension Benign Secondary Hypertension
malignant hypertension Malignant Secondary Hypertension

Diseases related to Malignant Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 167)
idRelated DiseaseScoreTop Affiliating Genes
1purpura31.2ADAMTS13
2thrombotic thrombocytopenic purpura31.0ADAMTS13
3phaeochromocytoma30.8ADM, CHGA
4fibromuscular dysplasia30.8REN
5hemolytic-uremic syndrome30.7ADAMTS13, VWF
6conn's syndrome30.7AGTR1, REN, ADM
7nephrosclerosis30.6ADM, ACE, AGTR1
8central retinal vein occlusion30.6APOH
9thrombocytopenia30.5VWF, APOH, ADAMTS13
10adrenal adenoma30.4ADM, REN
11antiphospholipid syndrome30.4VWF, APOH, ADAMTS13
12hemolytic anemia30.4VWF, APOH, ADAMTS13
13vascular disease30.3APOH, VWF
14hyperaldosteronism30.1REN, ACE, AGTR1
15hypokalemia30.1REN, ACE, DNAH8
16focal segmental glomerulosclerosis30.0ACE, AGTR1, TRPC6
17renal hypertension29.8EDN1, ADM, REN, ACE
18kidney disease29.7AGTR1, AGT, DNAH8, REN
19hyperglycemia29.5AGTR1, AGT, DNAH8, ACE
20proteinuria29.2TRPC6, AGTR1, AGT, ACE, REN, ADAMTS13
21ischemia29.1EDN1, ADM, ADAMTS13, DNAH8, NPPB, AGT
22glomerulosclerosis29.1TRPC6, AGTR1, AGT, ACE, REN, ADM
23congestive heart failure10.6REN
24hypoaldosteronism10.5REN
25oligohydramnios10.5ACE
26orthostatic intolerance10.5AGTR1
27zollinger-ellison syndrome10.5CHGA
28eisenmenger syndrome10.4VWF
29hypertensive encephalopathy10.4
30retinal artery occlusion10.4APOH
31glomerulonephritis10.4
32hypertensive retinopathy10.4
33gitelman syndrome10.3REN, AGT
34cerebritis10.3
35retinitis10.3
36heart valve disease10.3NPPB, APOH
37hypertension, diastolic10.3ACE, REN
38hepatorenal syndrome10.3REN, EDN1
39pheochromocytoma10.3
40adenoma10.3
41papilledema10.3
42pyelonephritis10.3
43scleroderma10.3
44intracranial thrombosis10.3APOH, VWF
45factor xii deficiency10.3APOH, VWF
46collagen disease10.3VWF, APOH
47pure autonomic failure10.3REN, ACE
48adrenocortical carcinoma10.3ADM, CHGA, AGTR1
49renal tubular dysgenesis10.3REN, AGT, AGTR1
50diabetic angiopathy10.2EDN1, ADM

Graphical network of the top 20 diseases related to Malignant Hypertension:



Diseases related to malignant hypertension

Symptoms for Malignant Hypertension

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Drugs & Therapeutics for Malignant Hypertension

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Genetic Tests for Malignant Hypertension

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Anatomical Context for Malignant Hypertension

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MalaCards organs/tissues related to Malignant Hypertension:

31
Kidney, Brain, Liver, Adrenal gland, Endothelial, Eye, Lymph node, Spleen, Spinal cord, Heart, Small intestine

Animal Models for Malignant Hypertension or affiliated genes

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MGI Mouse Phenotypes related to Malignant Hypertension:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1ADM, REN, NPPB, AGT, TRPC6, EDN1
2MP:00053677.7EDN1, ADM, CHGA, REN, ACE, AGT
3MP:00053877.0VWF, ADM, ADAMTS13, REN, ACE, AGT
4MP:00053766.2ADM, APOH, VWF, EDN1, ADAMTS13, CHGA
5MP:00107686.1ADM, APOH, VWF, EDN1, ADAMTS13, CHGA
6MP:00053855.9TRPC3, EDN1, VWF, ADM, CHGA, REN

Publications for Malignant Hypertension

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Articles related to Malignant Hypertension:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Diagnosis of malignant hypertension with ocular examination: a child case. (24168178)
2014
2
Malignant hypertension and interferon-beta: a case report. (24067346)
2013
3
Mortality and Cardiovascular Risk in Patients With a History of Malignant Hypertension: A Case-Control Study. (24373528)
2013
4
Intravitreal bevacizumab in persistent retinopathy secondary to malignant hypertension. (23964183)
2013
5
Telmisartan prevents excess-salt-induced exacerbated (malignant) hypertension in spontaneously hypertensive rats. (22927675)
2013
6
Malignant hypertension in patients treated with vascular endothelial growth factor inhibitors. (23458595)
2013
7
An Extra-adrenal Pheochromocytoma Presenting as Malignant Hypertension-A Report of two cases. (23905134)
2013
8
Malignant hypertension with an unusual presentation mimicking the immune mediated pulmonary renal syndrome. (23074127)
2012
9
Neonatal midaortic syndrome and renal artery atresia presenting as malignant hypertension. (22447383)
2012
10
Common genetic variants in the chromogranin a promoter are associated with renal injury in IgA nephropathy patients with malignant hypertension. (20113265)
2010
11
Increased TRPC3 expression in vascular endothelium of patients with malignant hypertension. (19136933)
2009
12
Malignant hypertension and acute aortic dissection associated with caffeine-based ephedra-free dietary supplements: a case report. (20181166)
2009
13
The renin-angiotensin system in malignant hypertension revisited: plasma renin activity, microangiopathic hemolysis, and renal failure in malignant hypertension. (17679041)
2007
14
Malignant hypertension, polycythemia, and paragangliomas. (16647420)
2006
15
Ophthalmoscopic findings in malignant hypertension. (16523002)
2006
16
Malignant hypertension with intestinal ischemia secondary to juxtaglomerular cell tumor. (16253738)
2005
17
A rare case of alveolar haemorrhage due to malignant hypertension. (16046511)
2005
18
Sudden sensorineural hearing loss after rapid reduction of blood pressure in malignant hypertension. (14763578)
2004
19
Malignant hypertension and cerebral haemorrhage in Seckel syndrome. (14564517)
2003
20
Malignant hypertension with a rare complication of pulmonary alveolar hemorrhage. (10644871)
2000
21
Outcome of patients with malignant hypertension and end-stage renal failure treated by long-term hemodialysis. (10702650)
1999
22
Malignant hypertension and paraganglioma in a 14-year-old girl. (9932276)
1999
23
Despite low plasma renin ACE inhibitor treatment causes recovery from acute renal failure in a patient with malignant hypertension. (9550666)
1998
24
Are vasopressin peripheral V1 receptors involved in the development of malignant hypertension and stroke in SHR-SPs? (8617411)
1995
25
Malignant hypertension is accompanied by marked alterations in chylomicron metabolism. (7498998)
1995
26
Malignant hypertension. (2040938)
1991
27
Phlebotomy for erythropoietin-associated malignant hypertension. (1673767)
1991
28
The survival of malignant hypertension in blacks, whites and Asians in Britain. (2338701)
1990
29
Malignant hypertension in women of childbearing age and its relation to the contraceptive pill. (3107691)
1987
30
Malignant hypertension due to a renin-secreting renal cell carcinoma--an ultrastructural and immunocytochemical study. (3536712)
1986
31
Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy. (3808599)
1986
32
Malignant hypertension in end-stage renal failure: hemodynamic and hormone status. (3913571)
1985
33
Plasma prolactin levels in patients with essential hypertension, malignant hypertension and secondary hypertension. (3889434)
1985
34
Vascular lesions and angiotensin in malignant hypertension in the absence of vasopressin. (6754178)
1982
35
Blood pressure in acute and chronic vasopressin excess: studies of malignant hypertension and the syndrome of inappropriate antidiuretic hormone secretion. (7207565)
1981
36
Analysis of 30 patients with malignant hypertension treated with hemodialysis. (6118966)
1981
37
Relief from malignant hypertension by treatment with captopril in a patient on maintenance hemodialysis. (7003235)
1980
38
Malignant hypertension and cigarette smoking. (427451)
1979
39
Use of the oral angiotensin I--converting enzyme inhibitor (captopril) in childhood malignant hypertension. (383935)
1979
40
Resolution of renal failure with malignant hypertension in scleroderma. Case report and review of the literature. (474603)
1979
41
Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. (633491)
1978
42
Pathogenesis of malignant hypertension: experimental evidence from the renal hypertensive rat. (1192618)
1975
43
Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma. (178085)
1975
44
Malignant hypertension due to musculo-mucoid intimal hyperplasia of intrarenal arteries. Absence of renal fibrinoid necrosis. (48431)
1975
45
The unresolved nature of malignant hypertension. (4467901)
1974
46
Bilateral nephrectomy as a treatment of malignant hypertension. (4459310)
1974
47
Renomedullary antihypertensive function in accelerated (malignant) hypertension. Observations on renomedullary interstitial cells. (4108666)
1972
48
Oral diazoxide for malignant hypertension. (4113603)
1972
49
Malignant hypertension following the administration of cortisone in periarteritis nodosa. (14856504)
1951
50
Benign and Malignant Hypertension and Nephrosclerosis: A Clinical and Pathological Study. (19970253)
1936

Variations for Malignant Hypertension

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Expression for genes affiliated with Malignant Hypertension

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Search GEO for disease gene expression data for Malignant Hypertension.

Pathways for genes affiliated with Malignant Hypertension

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Compounds for genes affiliated with Malignant Hypertension

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Compounds related to Malignant Hypertension according to GeneCards Suite gene sharing:

(show top 50)    (show all 212)
idCompoundScoreTop Affiliating Genes
1aliskiren44 1110.3AGTR1, REN, ACE, AGT
2saralasin449.3AGTR1, AGT, ACE, REN
3eprosartan44 28 1111.3ACE, AGTR1, AGT, REN
4olmesartan44 28 1111.0REN, AGTR1, AGT, ACE
5fosinopril44 1110.0REN, AGTR1, NPPB, ACE
6lacidipine449.0EDN1, REN, ACE, AGTR1
7omapatrilat449.0EDN1, ADM, REN, ACE
8lisinopril44 50 24 1112.0AGTR1, AGT, NPPB, ACE, REN
9telmisartan44 28 1110.9AGTR1, NPPB, ACE, REN, AGT
10cilazapril44 119.9AGTR1, ACE, REN, EDN1
11candesartan44 50 28 1111.9AGTR1, AGT, NPPB, REN, ACE
12amlodipine44 50 24 1111.9ACE, AGTR1, AGT, NPPB, REN
13chymostatin448.7EDN1, ACE, AGT, REN, AGTR1
14irbesartan44 28 50 1111.7AGT, EDN1, REN, ACE, AGTR1
15enalaprilat448.7REN, ACE, NPPB, AGT, EDN1
16trandolapril44 119.7REN, ACE, AGTR1, NPPB, EDN1
17benazepril44 50 1110.7AGTR1, AGT, ACE, REN
18diltiazem44 28 50 1111.7EDN1, ACE, AGTR1, REN, AGT
19bisoprolol44 50 1110.7VWF, REN, ACE, NPPB
20digoxin44 60 50 24 1112.6REN, AGTR1, ACE, NPPB, DNAH8
21carvedilol44 50 28 1111.5REN, AGTR1, NPPB, ACE, ADM, EDN1
22nitroglycerin44 119.5ADM, REN, NPPB, EDN1, ACE, AGTR1
23phenylephrine44 28 24 1111.4EDN1, ADM, NPPB, AGT, AGTR1, TRPC6
24valsartan44 60 28 1111.4AGTR1, AGT, EDN1, REN, NPPB, ACE
25l-nmma448.4EDN1, ADM, AGT, AGTR1, NPPB
26cgmp44 289.4EDN1, ADM, REN, NPPB, AGT, AGTR1
27atenolol44 50 28 24 1112.4EDN1, REN, ACE, NPPB, AGT, AGTR1
28enalapril44 50 1110.4AGTR1, AGT, EDN1, NPPB, ACE, REN
29nifedipine44 28 50 1111.3CHGA, AGTR1, REN, ACE, AGT, EDN1
30quinapril44 50 1110.3VWF, REN, EDN1, ACE, AGTR1
31inositol 1,4,5 trisphosphate448.2CHGA, EDN1, TRPC6, TRPC3, ADM, AGT
32perindopril44 50 1110.2VWF, REN, ACE, AGT, AGTR1, NPPB
33captopril44 60 50 28 1112.1EDN1, ADM, REN, ACE, AGTR1, AGT
34ang ii448.1NPPB, AGT, AGTR1, REN, ADM, EDN1
35thromboxane a244 249.1ADM, APOH, AGT, AGTR1, VWF, EDN1
36sodium nitroprusside447.6REN, EDN1, ADM, AGTR1, VWF, NPPB
37isoproterenol44 118.5ADM, VWF, AGTR1, AGT, NPPB, REN
38cholesterol44 28 24 1110.3CHGA, AGT, VWF, APOH, ACE, REN
39losartan44 50 28 1110.3VWF, ADM, REN, ACE, NPPB, AGT
40lipid447.2AGT, NPPB, ACE, TRPC3, CHGA, ADM
41cyclosporin a44 28 609.2AGT, AGTR1, VWF, NPPB, DNAH8, ADAMTS13
42vegf447.2APOH, VWF, CHGA, ADM, EDN1, REN
43epinephrine44 24 119.0EDN1, VWF, ADM, CHGA, REN, DNAH8
44acetylcholine44 50 28 24 1110.8AGTR1, EDN1, VWF, AGT, NPPB, DNAH8
45prostacyclin446.7ADM, APOH, VWF, EDN1, ACE, NPPB
46arginine446.7AGT, DNAH8, REN, AGTR1, EDN1, VWF
47norepinephrine44 24 118.5ADM, CHGA, REN, ACE, DNAH8, VWF
48nitric oxide44 24 118.4ACE, REN, CHGA, ADM, APOH, VWF
49creatinine446.0APOH, ADM, ADAMTS13, VWF, CHGA, REN
50calcium44 50 24 118.4CHGA, ADAMTS13, APOH, VWF, EDN1, REN

GO Terms for genes affiliated with Malignant Hypertension

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Cellular components related to Malignant Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.2AGT, EDN1, APOH, ADM, ADAMTS13, REN
2extracellular regionGO:00055767.0VWF, ADM, CHGA, REN, ACE, NPPB

Biological processes related to Malignant Hypertension according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:003386410.1AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:000203410.1AGTR1, AGT
3regulation of renal sodium excretionGO:003581310.1AGT, AGTR1
4positive regulation of cholesterol esterificationGO:001087310.0AGTR1, AGT
5peptide catabolic processGO:004317110.0ADAMTS13, ACE
6low-density lipoprotein particle remodelingGO:003437410.0AGT, AGTR1
7regulation of renal output by angiotensinGO:000201910.0ACE, AGT
8positive regulation of cellular protein metabolic processGO:00322709.9AGTR1, AGT
9renin-angiotensin regulation of aldosterone productionGO:00020189.9REN, AGT, AGTR1
10regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.9AGTR1, ACE
11negative regulation of smooth muscle cell apoptotic processGO:00343929.9APOH, EDN1
12artery smooth muscle contractionGO:00148249.8AGT, EDN1
13positive regulation of heart rateGO:00104609.8ADM, EDN1
14negative regulation of angiogenesisGO:00165259.7APOH, AGT, NPPB
15positive regulation of cardiac muscle hypertrophyGO:00106139.7EDN1, AGT
16angiotensin maturationGO:00020039.7REN, AGT, ACE
17body fluid secretionGO:00075899.7NPPB, EDN1
18agingGO:00075689.6ADM, TRPC6, AGT
19negative regulation of blood coagulationGO:00301959.6EDN1, APOH
20regulation of vasodilationGO:00423129.6ACE, NPPB, AGTR1
21positive regulation of urine volumeGO:00358109.5NPPB, EDN1
22positive regulation of renal sodium excretionGO:00358159.5NPPB, AGT, EDN1
23response to lipopolysaccharideGO:00324969.5ADM, EDN1, REN
24positive regulation of macrophage derived foam cell differentiationGO:00107449.5AGTR1, AGT
25regulation of blood pressureGO:00082179.4NPPB, ACE, CHGA, REN
26positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:00514829.4AGTR1, EDN1
27blood coagulation, intrinsic pathwayGO:00075979.4APOH, VWF
28kidney developmentGO:00018229.3AGTR1, REN, ACE, AGT
29positive regulation of cytosolic calcium ion concentrationGO:00072049.1EDN1, ADM, AGTR1, TRPC6
30regulation of vasoconstrictionGO:00192299.0EDN1, ACE, AGT, AGTR1
31platelet activationGO:00301688.9TRPC6, ADAMTS13, VWF, TRPC3

Molecular functions related to Malignant Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1store-operated calcium channel activityGO:00152799.7TRPC3, TRPC6
2bradykinin receptor bindingGO:00317119.6ACE, AGTR1
3inositol 1,4,5 trisphosphate bindingGO:00706799.4TRPC3, TRPC6
4hormone activityGO:00051798.9AGT, NPPB, ADM, EDN1
5protein bindingGO:00055156.1EDN1, VWF, APOH, ADM, ADAMTS13, ACE

Sources for Malignant Hypertension

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet