MCID: MLG069
MIFTS: 60

Malignant Hypertension malady

Summaries for Malignant Hypertension

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63Wikipedia, 32MalaCards
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Wikipedia:63 A hypertensive emergency (formerly called \"malignant hypertension\") is hypertension (high blood... more...

MalaCards: Malignant Hypertension, also known as hypertension malignant, is related to hypertension and renal hypertension. An important gene associated with Malignant Hypertension is ADM (adrenomedullin), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The drugs captopril and diazoxide and the compounds captopril and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and liver, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Malignant Hypertension

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8Disease Ontology, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

malignant hypertension 8 60
hypertension malignant 44


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Disease Ontology8 DOID:10824
NCIt39 C3118
MeSH34 D006974

Related Diseases for Malignant Hypertension

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17GeneCards, 18GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension malignant hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Malignant Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.8ADM, ACE, REN, DNAH8, AGT, AGTR1
2renal hypertension31.2ADM, ACE, EDN1, REN
3essential hypertension30.6AGTR1, AGT, TRPC3, REN, EDN1, NPPB
4hypertensive encephalopathy30.5EPO
5glomerulonephritis30.4AGTR1
6pheochromocytoma30.3ADM, CHGA
7adenoma30.3CHGA, DNAH8, CYP1A1, REN
8purpura30.3ADAMTS13
9anuria30.2ACE
10hemolytic-uremic syndrome30.2VWF, ADAMTS13
11nephrosclerosis30.2ACE, AGTR1, ADM
12neuropathy30.2DNAH8
13conn's syndrome30.2REN
14paraganglioma30.1CHGA
15uremia30.1VWF, EPO
16renovascular hypertension30.1ADM, AGTR1, REN, ACE
17lupus erythematosus30.0APOH
18hypokalemia30.0REN, DNAH8, ACE
19antiphospholipid syndrome30.0APOH, ADAMTS13, VWF
20adrenal adenoma30.0ADM, CHGA, AGTR1, REN
21thrombocytopenia30.0VWF, ADAMTS13, EPO, APOH
22hemolytic anemia30.0APOH, ADAMTS13, VWF, EPO
23proteinuria30.0AGT, APOH, EDN1, AGTR1, TRPC6, REN
24vascular disease30.0EDN1, AGTR1, AGT, DNAH8, VWF, ACE
25retinal vein occlusion29.8APOH
26obesity29.8AGT
27cushing's syndrome29.8REN
28polycythemia29.8EPO
29central retinal vein occlusion29.8APOH
30arteriosclerosis29.8ADM, EDN1
31hyperaldosteronism29.8AGTR1, ACE, REN
32vasculitis29.8APOH, VWF
33focal segmental glomerulosclerosis29.8AGTR1, TRPC6, ACE
34hypertensive heart disease29.8NPPB, ACE, AGTR1
35primary pulmonary hypertension29.8EDN1, ADM, NPPB, AGT
36hyperglycemia29.8AGTR1, AGT, DNAH8, ACE
37systemic lupus erythematosus29.8ADAMTS13, CYP1A1, VWF, APOH
38ischemia29.8DNAH8, AGT, ADAMTS13, ADM, NPPB, EDN1
39ischemic heart disease29.8NPPB, EDN1, AGTR1, AGT, ACE, ADM
40diabetic nephropathy29.8REN, EDN1, AGTR1, AGT, EPO, VWF
41diabetes mellitus29.8ACE, VWF, REN, DNAH8, AGT, AGTR1
42malignant secondary hypertension10.5
43malignant essential hypertension10.4
44malignant hypertensive renal disease10.4
45hypertensive retinopathy10.4
46cerebritis10.3
47chronic pyelonephritis10.2
48papilledema10.2
49pyelonephritis10.2
50retinitis10.2

Graphical network of the top 20 diseases related to Malignant Hypertension:



Diseases related to malignant hypertension

Clinical Features for Malignant Hypertension

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Drugs & Therapeutics for Malignant Hypertension

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Malignant Hypertension

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Anatomical Context for Malignant Hypertension

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32MalaCards
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MalaCards organs/tissues related to Malignant Hypertension:

32
Kidney, Brain, Liver, Endothelial, Adrenal gland, Pancreas, Small intestine, Heart, Spleen, Eye, Lymph node, Spinal cord, Bone, Skin

Animal Models for Malignant Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7EDN1, AGT, TRPC6, REN, ADM, NPPB
2MP:00053677.9EDN1, AGTR1, AGT, CHGA, REN, ACE
3MP:00053767.8APOH, AGTR1, AGT, TRPC3, REN, VWF
4MP:00053877.3AGTR1, AGT, TRPC3, CYP1A1, REN, VWF
5MP:00107685.4CHGA, AGT, AGTR1, EDN1, APOH, TRPC3
6MP:00053855.4ADM, NPPB, EDN1, AGTR1, AGT, CHGA

Publications for Malignant Hypertension

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50PubMed
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Articles related to Malignant Hypertension:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Telmisartan prevents excess-salt-induced exacerbated (malignant) hypertension in spontaneously hypertensive rats. (22927675)
2013
2
An Extra-adrenal Pheochromocytoma Presenting as Malignant Hypertension-A Report of two cases. (23905134)
2013
3
Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy. (24049285)
2013
4
Direct renin inhibition with aliskiren normalizes blood pressure in Cyp1a1-Ren2 transgenic rats with inducible angiotensin ii-dependent malignant hypertension. (21358304)
2011
5
Malignant hypertension, dissection of aorta, cardiac tamponade and monoparesis--unusual presentation of Takayasu's arteritis: clinicopathological correlation. (18372065)
2009
6
Images in clinical medicine. Changes in the brain stem and fundus in malignant hypertension. (18450606)
2008
7
Idiopathic membranous nephropathy complicated with malignant hypertension: a case report. (17711746)
2007
8
Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. (16963204)
2007
9
Malignant hypertension after adrenalectomy. (15496569)
2004
10
ANCA-related crescentic glomerulonephritis in a patient with scleroderma without marked dermatological change and malignant hypertension. (15283187)
2004
11
Acute renal failure due to hypertension: malignant hypertension in an adolescent. (12828593)
2003
12
Desperate diseases, desperate measures: tackling malignant hypertension in the 1950s. (11479454)
2001
13
Role of increased circulating and renal adrenomedullin in rats with malignant hypertension. (11705795)
2001
14
Expression of 90-kDa heat shock protein within regenerative tubular cells in a patient with acute oliguric renal failure due to malignant hypertension. (10048123)
1999
15
Nifedipine and arotinolol in combination for accelerated-malignant hypertension: results of one year follow-up. (10487322)
1999
16
Human leukocyte antigens and malignant essential hypertension. (9657633)
1998
17
Malignant hypertension: still a challenge. (9306367)
1997
18
Malignant hypertension in a patient with primary aldosteronism with elevated active renin concentration. (9372330)
1997
19
Antihypertensive therapy reduces increased plasma levels of adrenomedullin and brain natriuretic peptide concomitant with regression of left ventricular hypertrophy in a patient with malignant hypertension. (10968202)
1996
20
Malignant hypertension in association with primary aldosteronism. (8809377)
1996
21
Malignant hypertension in children in India. (8672020)
1996
22
Malignant hypertension in a haemodialysis patient treated by ultrafiltration. (8643182)
1995
23
Kidney histology and clinical correlates in malignant hypertension. (8513738)
1993
24
Malignant hypertension and antiphospholipid antibodies as presenting features of SLE in a young woman using oral contraceptives. (1747706)
1991
25
Malignant hypertension. (1658131)
1991
26
High-renin malignant hypertension secondary to an aldosterone-producing adenoma. (2179760)
1990
27
Accelerated and malignant hypertension: experience from a large American inner city hospital. (2599664)
1989
28
Different cation transport inhibitor in malignant renal hypertension and in uraemia. (2924525)
1989
29
Loop diuretic-induced pancreatitis with rechallenge in a patient with malignant hypertension and renal insufficiency. (2458013)
1988
30
Pathophysiology in malignant hypertension: with special reference to the renin-angiotensin system. (3621700)
1987
31
Renal haemodynamics and comparative effects of captopril in patients with benign- or malignant-essential hypertension, or with chronic renal failure. (3301082)
1987
32
Malignant hypertension (a clinico-pathologic study of 43 cases). (3681746)
1987
33
Malignant hypertension due to a renin-secreting renal cell carcinoma--an ultrastructural and immunocytochemical study. (3536712)
1986
34
Fundus lesions in malignant hypertension. IV. Focal intraretinal periarteriolar transudates. (3951817)
1986
35
Malignant hypertension in end-stage renal failure: hemodynamic and hormone status. (3913571)
1985
36
Protracted anuria due to active renal vasoconstriction in malignant hypertension. (6423191)
1984
37
Malignant hypertension and HLA antigens. (6623451)
1983
38
Malignant hypertension-a case report. (7066155)
1982
39
Blood pressure in acute and chronic vasopressin excess: studies of malignant hypertension and the syndrome of inappropriate antidiuretic hormone secretion. (7207565)
1981
40
Coexistence of pheochromocytoma and renal artery occlusion in a patient with malignant hypertension. (7263197)
1981
41
Use of the oral angiotensin I--converting enzyme inhibitor (captopril) in childhood malignant hypertension. (383935)
1979
42
Factors affecting the care of patients with malignant hypertension. (439049)
1979
43
Sclerosing glomerulonephritis and malignant hypertension in a patient with congenital renal dysplasia: A case report. (550441)
1979
44
Editoral: Diazoxide in malignant hypertension. (4444606)
1974
45
Increased plasma renin substrate concentrations in human malignant hypertension. (4522177)
1973
46
Renomedullary antihypertensive function in accelerated (malignant) hypertension. Observations on renomedullary interstitial cells. (4108666)
1972
47
Bilateral nephrectomy for malignant hypertension. (4646220)
1972
48
Malignant renovascular hypertension in a newborn. (5956765)
1966
49
Role of somatotrophic hormone in the production of malignant nephrosclerosis, periarteritis nodosa, and hypertensive disease. (14821382)
1951
50
On the pathogenesis of red essential arterial hypertension and of malignant nephrosclerosis. (18857649)
1948

Genetic Variations for Malignant Hypertension

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Expression for genes affiliated with Malignant Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Hypertension

Search GEO for disease gene expression data for Malignant Hypertension.

Pathways for genes affiliated with Malignant Hypertension

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Malignant Hypertension

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44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Malignant Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1captopril44 28 49 59 1114.0ADM, REN, EDN1
2aliskiren44 1110.6AGTR1, AGT, REN, ACE
3saralasin449.5AGT, REN, ACE, AGTR1
4benazepril44 1110.5AGT, REN, ACE, AGTR1
5eprosartan44 28 1111.5ACE, REN, AGT, AGTR1
6lacidipine449.5EDN1, AGTR1, REN, ACE
7omapatrilat449.4REN, ADM, ACE, EDN1
8cilazapril44 1110.4EDN1, AGTR1, REN, ACE
9lisinopril44 11 2411.3AGTR1, AGT, REN, ACE, NPPB
10atenolol44 28 49 11 2413.3NPPB, AGTR1, AGT, REN, ACE
11telmisartan44 28 1111.2ACE, REN, AGT, NPPB, AGTR1
12fosinopril44 1110.2AGTR1, REN, NPPB, ACE
13trandolapril44 1110.2NPPB, AGTR1, REN, EDN1, ACE
14chymostatin449.2AGTR1, EDN1, AGT, REN, ACE
15bisoprolol44 49 1111.2REN, VWF, ACE, NPPB
16candesartan44 28 1111.2ACE, AGT, REN, AGTR1, NPPB
17enalaprilat449.2AGT, EDN1, NPPB, REN, ACE
18olmesartan44 28 1111.1ACE, REN, AGT, AGTR1
19cyclosporin a44 28 5911.1DNAH8, NPPB, ADAMTS13, ADM, EDN1
20diltiazem44 28 1111.1REN, ACE, AGT, AGTR1, EDN1
21norepinephrine44 11 2411.1ADM, CYP1A1, DNAH8, CHGA
22inositol 1,4,5 trisphosphate449.0ADM, EDN1, CHGA, TRPC6, TRPC3
23quinapril44 1110.0ACE, VWF, REN, AGTR1, EDN1
24nitroglycerin44 1110.0NPPB, AGTR1, REN, ACE, ADM, EDN1
25phenylephrine44 28 11 2411.9ADM, TRPC6, NPPB, AGT, AGTR1, EDN1
26valsartan44 59 28 1111.9REN, NPPB, EDN1, AGTR1, AGT, ACE
27amlodipine44 49 11 2411.8CYP1A1, REN, ACE, AGT, AGTR1, NPPB
28digoxin44 49 59 11 2412.8ACE, NPPB, REN, AGTR1, DNAH8
29perindopril44 49 1110.8AGTR1, ACE, VWF, REN, NPPB, AGT
30isoproterenol44 119.8AGTR1, VWF, CYP1A1, CHGA, ADM
31thromboxane a244 249.7AGTR1, APOH, VWF, ADM, EDN1, AGT
32ang ii448.7EDN1, ADM, ACE, REN, AGT, AGTR1
33cgmp44 289.6EDN1, NPPB, AGT, REN, ADM, AGTR1
34l-nmma448.6ADM, NPPB, EDN1, AGT, AGTR1
35carvedilol44 49 28 1111.6NPPB, EDN1, AGTR1, CYP1A1, REN, ACE
36haloperidol44 28 2 49 1112.5AGTR1, NPPB, AGT, REN, CHGA, CYP1A1
37sodium nitroprusside448.3NPPB, ADM, AGTR1, DNAH8, REN, EDN1
38losartan44 49 28 1111.2ADM, ACE, VWF, REN, AGT, EDN1
39nifedipine44 49 28 1111.1CYP1A1, ACE, CHGA, AGT, AGTR1, EDN1
40enalapril44 49 1110.1AGT, ACE, REN, NPPB, EDN1, AGTR1
41ouabain44 119.0EPO, CYP1A1, EDN1, DNAH8, NPPB
42indomethacin44 59 28 1111.0NPPB, CYP1A1, DNAH8, REN, ADM, EDN1
43prostacyclin447.7NPPB, APOH, EDN1, AGTR1, ADM, ACE
44epinephrine44 11 249.4VWF, REN, DNAH8, CHGA, AGT, AGTR1
45acetylcholine44 49 28 11 2411.3VWF, CHGA, ADM, AGT, AGTR1, EDN1
46nitric oxide44 11 249.0CHGA, TRPC3, AGT, AGTR1, ADM, ACE
47arginine446.7AGT, DNAH8, CYP1A1, REN, VWF, ADM
48vegf446.4AGTR1, EDN1, NPPB, APOH, AGT, CHGA
49calcium44 49 11 249.1NPPB, ADAMTS13, ACE, VWF, REN, TRPC3
50creatinine445.7APOH, NPPB, EDN1, AGTR1, AGT, CHGA

GO Terms for genes affiliated with Malignant Hypertension

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16Gene Ontology
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Cellular components related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056156.9ADM, APOH, NPPB, EDN1, AGT, EPO
2extracellular regionGO:0055766.6EDN1, AGT, CHGA, EPO, REN, VWF

Biological processes related to Malignant Hypertension according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.2AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.2AGT, AGTR1
3peptide catabolic processGO:04317110.2ACE, ADAMTS13
4regulation of renal sodium excretionGO:03581310.2AGT, AGTR1
5positive regulation of cholesterol esterificationGO:01087310.2AGT, AGTR1
6regulation of renal output by angiotensinGO:00201910.1AGT, ACE
7negative regulation of smooth muscle cell apoptotic processGO:03439210.1APOH, EDN1
8regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.1AGTR1, ACE
9low-density lipoprotein particle remodelingGO:03437410.1AGTR1, AGT
10positive regulation of cellular protein metabolic processGO:03227010.1AGTR1, AGT
11artery smooth muscle contractionGO:01482410.0AGT, EDN1
12positive regulation of cardiac muscle hypertrophyGO:01061310.0EDN1, AGT
13positive regulation of heart rateGO:01046010.0EDN1, ADM
14renin-angiotensin regulation of aldosterone productionGO:00201810.0REN, AGT, AGTR1
15body fluid secretionGO:00758910.0NPPB, EDN1
16positive regulation of urine volumeGO:03581010.0NPPB, EDN1
17angiotensin maturationGO:0020039.9ACE, REN, AGT
18maternal process involved in parturitionGO:0601379.9EDN1, CYP1A1
19negative regulation of blood coagulationGO:0301959.9APOH, EDN1
20regulation of vasodilationGO:0423129.9ACE, AGTR1, NPPB
21positive regulation of renal sodium excretionGO:0358159.8NPPB, EDN1, AGT
22elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.8AGTR1, EDN1
23positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
24elevation of cytosolic calcium ion concentrationGO:0072049.6EDN1, AGTR1, TRPC6, ADM
25response to woundingGO:0096119.6CYP1A1, VWF, ADM
26kidney developmentGO:0018229.6ACE, REN, AGT, AGTR1
27platelet activationGO:0301689.5ADAMTS13, VWF, TRPC3, TRPC6
28regulation of vasoconstrictionGO:0192299.5ACE, AGT, AGTR1, EDN1
29response to vitamin AGO:0331899.4EPO, CYP1A1
30response to salt stressGO:0096519.4EPO, AGT
31blood coagulation, intrinsic pathwayGO:0075979.4VWF, APOH
32response to hyperoxiaGO:0550939.3EPO, CYP1A1
33regulation of blood pressureGO:0082179.3NPPB, CHGA, REN, ACE
34response to testosterone stimulusGO:0335749.2EPO, EDN1
35agingGO:0075689.0AGT, EPO, CYP1A1, ADM
36response to lipopolysaccharideGO:0324968.7EDN1, EPO, CYP1A1, REN, ADM

Molecular functions related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.9AGTR1, ACE
2acetyltransferase activator activityGO:0106989.9AGTR1, AGT
3inositol 1,4,5 trisphosphate bindingGO:0706799.8TRPC3, TRPC6
4store-operated calcium channel activityGO:0152799.6TRPC6, TRPC3
5hormone activityGO:0051798.5ADM, EPO, AGT, EDN1, NPPB
6protein bindingGO:0055156.5EDN1, AGTR1, AGT, TRPC6, TRPC3, EPO

Products for genes affiliated with Malignant Hypertension

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Sources for Malignant Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet