MCID: MLG069
MIFTS: 53

Malignant Hypertension malady

Summaries for Malignant Hypertension

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 A hypertensive emergency (formerly called \"malignant hypertension\") is hypertension (high blood... more...

MalaCards: Malignant Hypertension, also known as hypertension malignant, is related to hypertensive encephalopathy and pheochromocytoma. An important gene associated with Malignant Hypertension is ADM (adrenomedullin), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The drugs trimethaphan camsylate and captopril and the compounds captopril and aliskiren have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Malignant Hypertension

Sources:
8Disease Ontology, 61UMLS, 45Novoseek, 57SNOMED-CT, 40NCIt, 35MeSH
See all sources

Aliases & Descriptions:

malignant hypertension 8 61
hypertension malignant 45


External Ids:

Disease Ontology8 DOID:10824
NCIt40 C3118
MeSH35 D006974

Related Diseases for Malignant Hypertension

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the hypertension family:

benign essential hypertension malignant essential hypertension
essential hypertension malignant hypertension
familial hypertension hypertension, essential 3
hypertension, essential 7 hypertension, essential 6
hypertension, essential 4 hypertension, essential 2
hypertension, essential 1 hypertension, essential 8
hypertension, essential 5

Diseases related to Malignant Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 204)
idRelated DiseaseScoreTop Affiliating Genes
1hypertensive encephalopathy30.5EPO
2pheochromocytoma30.3ADM, CHGA
3adenoma30.3CHGA, DNAH8, CYP1A1, REN
4anuria30.3ACE
5hemolytic-uremic syndrome30.3VWF, ADAMTS13
6nephrosclerosis30.3ACE, AGTR1, ADM
7conn's syndrome30.2REN
8paraganglioma30.2CHGA
9uremia30.2VWF, EPO
10renovascular hypertension30.2ADM, AGTR1, REN, ACE
11lupus nephritis30.1ADAMTS13, APOH
12nephritis30.1ACE, APOH
13hypokalemia30.0REN, DNAH8, ACE
14antiphospholipid syndrome30.0APOH, ADAMTS13, VWF
15adrenal adenoma30.0ADM, CHGA, AGTR1, REN
16thrombocytopenia30.0VWF, ADAMTS13, EPO, APOH
17vascular disease30.0EDN1, AGTR1, AGT, DNAH8, VWF, ACE
18cushing's syndrome29.8REN
19central retinal vein occlusion29.8APOH
20arteriosclerosis29.8ADM, EDN1
21vasculitis29.8APOH, VWF
22focal segmental glomerulosclerosis29.8AGTR1, TRPC6, ACE
23primary pulmonary hypertension29.8EDN1, ADM, NPPB, AGT
24systemic lupus erythematosus29.8ADAMTS13, CYP1A1, VWF, APOH
25diabetic nephropathy29.8REN, EDN1, AGTR1, AGT, EPO, VWF
26malignant essential hypertension10.4
27nephropathy-hypertension10.4
28hypertensive retinopathy10.3
29n syndrome10.2
30malignant hypertensive renal disease10.1
31thrombotic thrombocytopenic purpura10.1
32phaeochromocytoma10.1
33malignant renovascular hypertension10.1
34periarteritis nodosa10.1
35blindness10.1
36cardiac tamponade10.1
37acute pancreatitis10.1
38polyarteritis nodosa10.1
39ocular hypertension10.1
40atypical hemolytic-uremic syndrome10.1
41purpura10.0ADAMTS13
42congestive heart failure10.0REN
43fibromuscular dysplasia10.0REN
44leiomyoma10.0ADM
45lupus erythematosus10.0APOH
46migraine10.0APOH
47glomerulonephritis10.0AGTR1
48ovarian hyperstimulation syndrome10.0REN
49retinal vein occlusion10.0APOH
50arthritis10.0AGTR1

Graphical network of the top 20 diseases related to Malignant Hypertension:



Diseases related to malignant hypertension

Clinical Features for Malignant Hypertension

Drugs & Therapeutics for Malignant Hypertension

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Malignant Hypertension

Anatomical Context for Malignant Hypertension

Animal Models for Malignant Hypertension or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Malignant Hypertension

Sources:
51PubMed
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Articles related to Malignant Hypertension:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Malignant hypertension and interferon-beta: a case report. (24067346)
2013
2
Mortality and Cardiovascular Risk in Patients With a History of Malignant Hypertension: A Case-Control Study. (24373528)
2013
3
Intravitreal bevacizumab in persistent retinopathy secondary to malignant hypertension. (23964183)
2013
4
Systemic therapies for malignant pheochromocytoma and paraganglioma can exacerbate hypertension. (23815541)
2013
5
A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension. (23448537)
2013
6
Malignant hypertension with reversible brainstem hypertensive encephalopathy and thrombotic microangiopathy. (22418002)
2012
7
Intravitreal bevacizumab in a patient with a macular star in malignant hypertension. (20954147)
2011
8
Malignant hypertension secondary to renovascular disease during infancy--an unusual cause of failure to thrive. (21965587)
2011
9
Ethnic disparities in the incidence, presentation and complications of malignant hypertension. (17053554)
2006
10
Temporary losartan or captopril in young SHR induces malignant hypertension despite initial normotension. (14717927)
2004
11
Malignant hypertension presenting as hemolysis, thrombocytopenia, and renal failure. (14674379)
2003
12
Role of increased circulating and renal adrenomedullin in rats with malignant hypertension. (11705795)
2001
13
Recurrent malignant hypertension: a report of two cases and review of the literature. (10583722)
1999
14
Inhibition of tissue angiotensin converting enzyme activity prevents malignant hypertension in TGR(mREN2)27. (9797175)
1998
15
Malignant hypertension associated with obstructive hydrocephalus--case report. (9095627)
1997
16
Neck pain as a presenting symptom in malignant hypertension. (9023628)
1997
17
Malignant hypertension and antiphospholipid syndrome. (8773396)
1996
18
Are vasopressin peripheral V1 receptors involved in the development of malignant hypertension and stroke in SHR-SPs? (8617411)
1995
19
Severe hypertension with lone bilateral papilloedema: a variant of malignant hypertension. (8746600)
1995
20
Partial recovery of renal function in black patients with apparent end-stage renal failure due to primary malignant hypertension. (8538845)
1995
21
Increased production of angiotensin II in the adrenal gland of stroke-prone spontaneously hypertensive rats with malignant hypertension. (2069554)
1991
22
Prognostic factors in malignant hypertension selected by multivariate analysis. (23275987)
1990
23
Malignant hypertension presenting as acute pancreatitis. (2607524)
1989
24
Successful treatment of Legionella-associated haemolytic uraemic syndrome with acute renal failure and malignant hypertension by prostacyclin (epoprostenol). (2516894)
1989
25
Contribution of vasopressin to the maintenance of blood pressure in deoxycorticosterone-salt induced malignant hypertension in spontaneously hypertensive rats. (3956109)
1986
26
Retinal changes in malignant hypertension. (3081083)
1986
27
Abnormal haemostasis and blood viscosity in malignant hypertension. (6241751)
1984
28
Malignant hypertension in a young boy. (6746528)
1984
29
DOCA-salt induced malignant hypertension in spontaneously hypertensive rats. (6530537)
1984
30
Abnormalities of vascular wall sodium content in dogs with benign and malignant renal hypertension. (6723084)
1984
31
Oral converting enzyme inhibitor in malignant hypertension. (6280623)
1982
32
Malignant hypertension: a syndrome associated with low plasma kininogen and kinin potentiating factor. (7028621)
1981
33
Coexistence of pheochromocytoma and renal artery occlusion in a patient with malignant hypertension. (7263197)
1981
34
Relief from malignant hypertension by treatment with captopril in a patient on maintenance hemodialysis. (7003235)
1980
35
Usefulness of orally active angiotensin I converting enzyme inhibitor (SQ 14,225) in the treatment of malignant hypertension. (6247259)
1980
36
Renal artery stenosis in malignant hypertension. (6105571)
1980
37
Malignant hypertension revisited: the role of bilateral nephrectomy. (6991710)
1980
38
Malignant hypertension and cigarette smoking. (427451)
1979
39
On the lipid granularity of renomedullary interstitial cells in benign and malignant courses of renal hypertension. (477821)
1979
40
Hypertensive encephalopathy and the neurological manifestations of malignant hypertension. (553413)
1979
41
Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. (633491)
1978
42
Management of malignant hypertension complicated by renal insufficiency. A follow-up study. (4832398)
1974
43
Bilateral nephrectomy for renal failure and hypertension due to malignant nephrosclerosis. (4619666)
1974
44
Treatment of malignant hypertension with sodium nitroprusside. (4812743)
1974
45
Bilateral nephrectomy for malignant hypertension. (4113447)
1972
46
Hypokalemia with normal blood pressure preceding malignant hypertension in a patient with primary aldosteronism (Conn's syndrome). (4509127)
1972
47
Malignant renovascular hypertension in a newborn. (5956765)
1966
48
LUPUS ERYTHEMATOSUS WITH FATAL HEMORRHAGE INTO THE LIVER AND LESIONS RESEMBLING THOSE OF PERIARTERITIS NODOSA AND MALIGNANT HYPERTENSION. IMMUNOCYTOCHEMICAL OBSERVATIONS. (14162899)
1964
49
Malignant nephrosclerosis and renal tuberculosis; report of a case with granulomatous periarteritis nodosa, tuberculous nephritis, and hypertension. (13337303)
1956
50
Clinicopathologic conference; generalized arteriosclerosis; malignant essential hypertension with dissecting aneurysm of the artery and coronary occlusion. (15426209)
1950

Genetic Variations for Malignant Hypertension

Expression for genes affiliated with Malignant Hypertension

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malignant Hypertension

Search GEO for disease gene expression data for Malignant Hypertension.

Pathways for genes affiliated with Malignant Hypertension

Sources:
50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 12EMD Millipore
See all sources

Compounds for genes affiliated with Malignant Hypertension

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
See all sources

Compounds related to Malignant Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1captopril45 29 50 60 1114.0ADM, REN, EDN1
2aliskiren45 1110.6AGTR1, AGT, REN, ACE
3saralasin459.5AGT, REN, ACE, AGTR1
4benazepril45 1110.5AGT, REN, ACE, AGTR1
5eprosartan45 29 1111.5ACE, REN, AGT, AGTR1
6lacidipine459.5EDN1, AGTR1, REN, ACE
7omapatrilat459.4REN, ADM, ACE, EDN1
8cilazapril45 1110.4EDN1, AGTR1, REN, ACE
9lisinopril45 11 2411.3AGTR1, AGT, REN, ACE, NPPB
10atenolol45 29 50 11 2413.3NPPB, AGTR1, AGT, REN, ACE
11telmisartan45 29 1111.2ACE, REN, AGT, NPPB, AGTR1
12fosinopril45 1110.2AGTR1, REN, NPPB, ACE
13trandolapril45 1110.2NPPB, AGTR1, REN, EDN1, ACE
14chymostatin459.2AGTR1, EDN1, AGT, REN, ACE
15bisoprolol45 50 1111.2REN, VWF, ACE, NPPB
16candesartan45 29 1111.2ACE, AGT, REN, AGTR1, NPPB
17enalaprilat459.2AGT, EDN1, NPPB, REN, ACE
18olmesartan45 29 1111.1ACE, REN, AGT, AGTR1
19cyclosporin a45 29 6011.1DNAH8, NPPB, ADAMTS13, ADM, EDN1
20diltiazem45 29 1111.1REN, ACE, AGT, AGTR1, EDN1
21norepinephrine45 11 2411.1ADM, CYP1A1, DNAH8, CHGA
22inositol 1,4,5 trisphosphate459.0ADM, EDN1, CHGA, TRPC6, TRPC3
23quinapril45 1110.0ACE, VWF, REN, AGTR1, EDN1
24nitroglycerin45 1110.0NPPB, AGTR1, REN, ACE, ADM, EDN1
25phenylephrine45 29 11 2411.9ADM, TRPC6, NPPB, AGT, AGTR1, EDN1
26valsartan45 60 29 1111.9REN, NPPB, EDN1, AGTR1, AGT, ACE
27amlodipine45 50 11 2411.8CYP1A1, REN, ACE, AGT, AGTR1, NPPB
28digoxin45 50 60 11 2412.8ACE, NPPB, REN, AGTR1, DNAH8
29perindopril45 50 1110.8AGTR1, ACE, VWF, REN, NPPB, AGT
30isoproterenol45 119.8AGTR1, VWF, CYP1A1, CHGA, ADM
31thromboxane a245 249.7AGTR1, APOH, VWF, ADM, EDN1, AGT
32ang ii458.7EDN1, ADM, ACE, REN, AGT, AGTR1
33cgmp45 299.6EDN1, NPPB, AGT, REN, ADM, AGTR1
34l-nmma458.6ADM, NPPB, EDN1, AGT, AGTR1
35carvedilol45 50 29 1111.6NPPB, EDN1, AGTR1, CYP1A1, REN, ACE
36haloperidol45 29 2 50 1112.5AGTR1, NPPB, AGT, REN, CHGA, CYP1A1
37sodium nitroprusside458.3NPPB, ADM, AGTR1, DNAH8, REN, EDN1
38losartan45 50 29 1111.2ADM, ACE, VWF, REN, AGT, EDN1
39nifedipine45 50 29 1111.1CYP1A1, ACE, CHGA, AGT, AGTR1, EDN1
40enalapril45 50 1110.1AGT, ACE, REN, NPPB, EDN1, AGTR1
41ouabain45 119.0EPO, CYP1A1, EDN1, DNAH8, NPPB
42indomethacin45 60 29 1111.0NPPB, CYP1A1, DNAH8, REN, ADM, EDN1
43prostacyclin457.7NPPB, APOH, EDN1, AGTR1, ADM, ACE
44epinephrine45 11 249.4VWF, REN, DNAH8, CHGA, AGT, AGTR1
45acetylcholine45 50 29 11 2411.3VWF, CHGA, ADM, AGT, AGTR1, EDN1
46nitric oxide45 11 249.0CHGA, TRPC3, AGT, AGTR1, ADM, ACE
47arginine456.7AGT, DNAH8, CYP1A1, REN, VWF, ADM
48vegf456.4AGTR1, EDN1, NPPB, APOH, AGT, CHGA
49calcium45 50 11 249.1NPPB, ADAMTS13, ACE, VWF, REN, TRPC3
50creatinine455.7APOH, NPPB, EDN1, AGTR1, AGT, CHGA

GO Terms for genes affiliated with Malignant Hypertension

Sources:
16Gene Ontology
See all sources

Cellular components related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056156.9ADM, APOH, NPPB, EDN1, AGT, EPO
2extracellular regionGO:0055766.6EDN1, AGT, CHGA, EPO, REN, VWF

Biological processes related to Malignant Hypertension according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.2AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.2AGT, AGTR1
3peptide catabolic processGO:04317110.2ACE, ADAMTS13
4regulation of renal sodium excretionGO:03581310.2AGT, AGTR1
5positive regulation of cholesterol esterificationGO:01087310.2AGT, AGTR1
6regulation of renal output by angiotensinGO:00201910.1AGT, ACE
7negative regulation of smooth muscle cell apoptotic processGO:03439210.1APOH, EDN1
8regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.1AGTR1, ACE
9low-density lipoprotein particle remodelingGO:03437410.1AGTR1, AGT
10positive regulation of cellular protein metabolic processGO:03227010.1AGTR1, AGT
11artery smooth muscle contractionGO:01482410.0AGT, EDN1
12positive regulation of cardiac muscle hypertrophyGO:01061310.0EDN1, AGT
13positive regulation of heart rateGO:01046010.0EDN1, ADM
14renin-angiotensin regulation of aldosterone productionGO:00201810.0REN, AGT, AGTR1
15body fluid secretionGO:00758910.0NPPB, EDN1
16positive regulation of urine volumeGO:03581010.0NPPB, EDN1
17angiotensin maturationGO:0020039.9ACE, REN, AGT
18maternal process involved in parturitionGO:0601379.9EDN1, CYP1A1
19negative regulation of blood coagulationGO:0301959.9APOH, EDN1
20regulation of vasodilationGO:0423129.9ACE, AGTR1, NPPB
21positive regulation of renal sodium excretionGO:0358159.8NPPB, EDN1, AGT
22elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.8AGTR1, EDN1
23positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
24elevation of cytosolic calcium ion concentrationGO:0072049.6EDN1, AGTR1, TRPC6, ADM
25response to woundingGO:0096119.6CYP1A1, VWF, ADM
26kidney developmentGO:0018229.6ACE, REN, AGT, AGTR1
27platelet activationGO:0301689.5ADAMTS13, VWF, TRPC3, TRPC6
28regulation of vasoconstrictionGO:0192299.5ACE, AGT, AGTR1, EDN1
29response to vitamin AGO:0331899.4EPO, CYP1A1
30response to salt stressGO:0096519.4EPO, AGT
31blood coagulation, intrinsic pathwayGO:0075979.4VWF, APOH
32response to hyperoxiaGO:0550939.3EPO, CYP1A1
33regulation of blood pressureGO:0082179.3NPPB, CHGA, REN, ACE
34response to testosterone stimulusGO:0335749.2EPO, EDN1
35agingGO:0075689.0AGT, EPO, CYP1A1, ADM
36response to lipopolysaccharideGO:0324968.7EDN1, EPO, CYP1A1, REN, ADM

Molecular functions related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.9AGTR1, ACE
2acetyltransferase activator activityGO:0106989.9AGTR1, AGT
3inositol 1,4,5 trisphosphate bindingGO:0706799.8TRPC3, TRPC6
4store-operated calcium channel activityGO:0152799.6TRPC6, TRPC3
5hormone activityGO:0051798.5ADM, EPO, AGT, EDN1, NPPB
6protein bindingGO:0055156.5EDN1, AGTR1, AGT, TRPC6, TRPC3, EPO

Products for genes affiliated with Malignant Hypertension

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Sources for Malignant Hypertension

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet