MCID: MLG069
MIFTS: 60

Malignant Hypertension malady

Summaries for Malignant Hypertension

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63Wikipedia, 32MalaCards
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Wikipedia:63 A hypertensive emergency (formerly called \"malignant hypertension\") is hypertension (high blood... more...

MalaCards: Malignant Hypertension, also known as hypertension malignant, is related to hypertension and renal hypertension. An important gene associated with Malignant Hypertension is ADM (adrenomedullin), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The drugs captopril and diazoxide and the compounds captopril and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and endothelial, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Malignant Hypertension

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8Disease Ontology, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

malignant hypertension 8 60
hypertension malignant 44


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Disease Ontology8 DOID:10824
NCIt39 C3118
MeSH34 D006974

Related Diseases for Malignant Hypertension

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17GeneCards, 18GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension malignant hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Malignant Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.8ADM, ACE, REN, DNAH8, AGT, AGTR1
2renal hypertension31.2ADM, ACE, EDN1, REN
3essential hypertension30.6AGTR1, AGT, TRPC3, REN, EDN1, NPPB
4hypertensive encephalopathy30.5EPO
5glomerulonephritis30.4AGTR1
6pheochromocytoma30.3ADM, CHGA
7adenoma30.3CHGA, DNAH8, CYP1A1, REN
8purpura30.3ADAMTS13
9anuria30.2ACE
10hemolytic-uremic syndrome30.2VWF, ADAMTS13
11nephrosclerosis30.2ACE, AGTR1, ADM
12neuropathy30.2DNAH8
13conn's syndrome30.2REN
14paraganglioma30.1CHGA
15uremia30.1VWF, EPO
16renovascular hypertension30.1ADM, AGTR1, REN, ACE
17lupus erythematosus30.0APOH
18hypokalemia30.0REN, DNAH8, ACE
19antiphospholipid syndrome30.0APOH, ADAMTS13, VWF
20adrenal adenoma30.0ADM, CHGA, AGTR1, REN
21thrombocytopenia30.0VWF, ADAMTS13, EPO, APOH
22hemolytic anemia30.0APOH, ADAMTS13, VWF, EPO
23proteinuria30.0AGT, APOH, EDN1, AGTR1, TRPC6, REN
24vascular disease30.0EDN1, AGTR1, AGT, DNAH8, VWF, ACE
25retinal vein occlusion29.8APOH
26obesity29.8AGT
27cushing's syndrome29.8REN
28polycythemia29.8EPO
29central retinal vein occlusion29.8APOH
30arteriosclerosis29.8ADM, EDN1
31hyperaldosteronism29.8AGTR1, ACE, REN
32vasculitis29.8APOH, VWF
33focal segmental glomerulosclerosis29.8AGTR1, TRPC6, ACE
34hypertensive heart disease29.8NPPB, ACE, AGTR1
35primary pulmonary hypertension29.8EDN1, ADM, NPPB, AGT
36hyperglycemia29.8AGTR1, AGT, DNAH8, ACE
37systemic lupus erythematosus29.8ADAMTS13, CYP1A1, VWF, APOH
38ischemia29.8DNAH8, AGT, ADAMTS13, ADM, NPPB, EDN1
39ischemic heart disease29.8NPPB, EDN1, AGTR1, AGT, ACE, ADM
40diabetic nephropathy29.8REN, EDN1, AGTR1, AGT, EPO, VWF
41diabetes mellitus29.8ACE, VWF, REN, DNAH8, AGT, AGTR1
42malignant secondary hypertension10.5
43malignant essential hypertension10.4
44malignant hypertensive renal disease10.4
45hypertensive retinopathy10.4
46cerebritis10.3
47chronic pyelonephritis10.2
48papilledema10.2
49pyelonephritis10.2
50retinitis10.2

Graphical network of the top 20 diseases related to Malignant Hypertension:



Diseases related to malignant hypertension

Clinical Features for Malignant Hypertension

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Drugs & Therapeutics for Malignant Hypertension

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Malignant Hypertension

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Anatomical Context for Malignant Hypertension

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32MalaCards
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MalaCards organs/tissues related to Malignant Hypertension:

32
Kidney, Brain, Endothelial, Liver, Adrenal gland, Skin, Pancreas, Small intestine, Heart, Spinal cord, Spleen, Lymph node, Bone, Eye

Animal Models for Malignant Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7EDN1, AGT, TRPC6, REN, ADM, NPPB
2MP:00053677.9EDN1, AGTR1, AGT, CHGA, REN, ACE
3MP:00053767.8APOH, AGTR1, AGT, TRPC3, REN, VWF
4MP:00053877.3AGTR1, AGT, TRPC3, CYP1A1, REN, VWF
5MP:00107685.4CHGA, AGT, AGTR1, EDN1, APOH, TRPC3
6MP:00053855.4ADM, NPPB, EDN1, AGTR1, AGT, CHGA

Publications for Malignant Hypertension

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50PubMed
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Articles related to Malignant Hypertension:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
A case of lipoprotein glomerulopathy with thrombotic microangiopathy due to malignant hypertension. (23448537)
2013
2
Malignant hypertension with reversible brainstem hypertensive encephalopathy and thrombotic microangiopathy. (22418002)
2012
3
Liver transplantation results in complete neurologic recovery from malignant hypertension secondary to fulminant hepatic failure: a case report. (22466917)
2012
4
Malignant hypertension secondary to renovascular disease during infancy--an unusual cause of failure to thrive. (21965587)
2011
5
Rapid recovery of visual acuity after lumboperitoneal shunt operation in malignant idiopathic intracranial hypertension. (22606459)
2011
6
Magnesium and vascular dysfunction in malignant hypertension. (21670414)
2011
7
Transient induction of ANG II-dependent malignant hypertension causes sustained elevation of blood pressure and augmentation of the pressor response to ANG II in CYP1A1-REN2 transgenic rats. (20375689)
2010
8
Malignant hypertension complicated by acute renal failure. (21686456)
2009
9
The malignant hypertension-thrombotic microangiopathy link. (18695140)
2008
10
The renin-angiotensin system in malignant hypertension revisited: plasma renin activity, microangiopathic hemolysis, and renal failure in malignant hypertension. (17679041)
2007
11
Thrombotic microangiopathy in cocaine abuse-associated malignant hypertension: report of 2 cases with review of the literature. (18081441)
2007
12
Malignant hypertension with intestinal ischemia secondary to juxtaglomerular cell tumor. (16253738)
2005
13
Malignant hypertension presenting as hemolysis, thrombocytopenia, and renal failure. (14674379)
2003
14
Angiotensin-converting enzyme gene I/D polymorphism in malignant hypertension. (10855732)
2000
15
Outcome of patients with malignant hypertension and end-stage renal failure treated by long-term hemodialysis. (10702650)
1999
16
Recurrent malignant hypertension: a report of two cases and review of the literature. (10583722)
1999
17
Malignant hypertension and hypertensive emergencies. (9440098)
1998
18
Images in clinical medicine. Malignant hypertension. (9869670)
1998
19
The fundus in malignant hypertension. (9249804)
1997
20
Malignant hypertension in antiphospholipid syndrome without overt lupus nephritis. (8275582)
1993
21
Conn's syndrome can cause malignant hypertension. (1583635)
1992
22
Ventricular function by radionuclide ventriculography in malignant hypertension. (1735581)
1992
23
Malignant hypertension. (2040938)
1991
24
Hydrocephalus associated with malignant hypertension and renal failure. (2243583)
1990
25
Pseudohypertension masquerading as malignant hypertension. Case report and review of the literature. (3279771)
1988
26
Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy. (3808599)
1986
27
Malignant hypertension: aetiology and outcome in 83 patients. (3769220)
1986
28
Plasma prolactin levels in patients with essential hypertension, malignant hypertension and secondary hypertension. (3889434)
1985
29
Glomerular & vascular changes in malignant hypertension. (6365372)
1984
30
Malignant hypertension in a young boy. (6746528)
1984
31
Acute intra-abdominal bleeding as a manifestation of malignant hypertension. (6985145)
1982
32
Understanding malignant hypertension. (6942804)
1981
33
The failure of furosemide-induced salt and water loss to convert benign to malignant hypertension in the rat. (7435539)
1980
34
Malignant hypertension: mechanisms and management. (6995999)
1980
35
Hypertensive encephalopathy and the neurological manifestations of malignant hypertension. (553413)
1979
36
Malignant hypertension presenting as gastrointestinal haemorrhage. (316707)
1979
37
Severe and prolonged renal insufficiency. Reversal in a patient with malignant hypertension. (628071)
1978
38
Malignant hypertension as a cause of massive intestinal bleeding. (17311)
1977
39
Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. (617906)
1977
40
Recovery from malignant hypertension with anuria after prolonged hemodialysis. (968548)
1976
41
Malignant hypertension secondary to idiopathic arteritis of the aorta. (974712)
1976
42
The renin-angiotensin system and the pathogenesis of vascular disease in malignant hypertension. (1071605)
1976
43
Malignant hypertension due to musculo-mucoid intimal hyperplasia of intrarenal arteries. Absence of renal fibrinoid necrosis. (48431)
1975
44
Malignant hypertension. Current modes of therapy. (4595400)
1974
45
Malignant hypertension with aldosteronoma producing adenoma. (4451199)
1974
46
Malignant hypertension treated with modern antihypertensive drugs. (4841134)
1974
47
Antihypertensive action of propranolol. Specific antirenin responses in high and normal renin forms of essential, renal, renovascular and malignant hypertension. (4729721)
1973
48
Malignant hypertension, uremia and hemolytic anemia in a patient on oral contraceptives. (5083217)
1972
49
LUPUS ERYTHEMATOSUS WITH FATAL HEMORRHAGE INTO THE LIVER AND LESIONS RESEMBLING THOSE OF PERIARTERITIS NODOSA AND MALIGNANT HYPERTENSION. IMMUNOCYTOCHEMICAL OBSERVATIONS. (14162899)
1964
50
Malignant nephrosclerosis and renal tuberculosis; report of a case with granulomatous periarteritis nodosa, tuberculous nephritis, and hypertension. (13337303)
1956

Genetic Variations for Malignant Hypertension

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Expression for genes affiliated with Malignant Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Hypertension

Search GEO for disease gene expression data for Malignant Hypertension.

Pathways for genes affiliated with Malignant Hypertension

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Malignant Hypertension

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44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Malignant Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1captopril44 28 49 59 1114.0ADM, REN, EDN1
2aliskiren44 1110.6AGTR1, AGT, REN, ACE
3saralasin449.5AGT, REN, ACE, AGTR1
4benazepril44 1110.5AGT, REN, ACE, AGTR1
5eprosartan44 28 1111.5ACE, REN, AGT, AGTR1
6lacidipine449.5EDN1, AGTR1, REN, ACE
7omapatrilat449.4REN, ADM, ACE, EDN1
8cilazapril44 1110.4EDN1, AGTR1, REN, ACE
9lisinopril44 11 2411.3AGTR1, AGT, REN, ACE, NPPB
10atenolol44 28 49 11 2413.3NPPB, AGTR1, AGT, REN, ACE
11telmisartan44 28 1111.2ACE, REN, AGT, NPPB, AGTR1
12fosinopril44 1110.2AGTR1, REN, NPPB, ACE
13trandolapril44 1110.2NPPB, AGTR1, REN, EDN1, ACE
14chymostatin449.2AGTR1, EDN1, AGT, REN, ACE
15bisoprolol44 49 1111.2REN, VWF, ACE, NPPB
16candesartan44 28 1111.2ACE, AGT, REN, AGTR1, NPPB
17enalaprilat449.2AGT, EDN1, NPPB, REN, ACE
18olmesartan44 28 1111.1ACE, REN, AGT, AGTR1
19cyclosporin a44 28 5911.1DNAH8, NPPB, ADAMTS13, ADM, EDN1
20diltiazem44 28 1111.1REN, ACE, AGT, AGTR1, EDN1
21norepinephrine44 11 2411.1ADM, CYP1A1, DNAH8, CHGA
22inositol 1,4,5 trisphosphate449.0ADM, EDN1, CHGA, TRPC6, TRPC3
23quinapril44 1110.0ACE, VWF, REN, AGTR1, EDN1
24nitroglycerin44 1110.0NPPB, AGTR1, REN, ACE, ADM, EDN1
25phenylephrine44 28 11 2411.9ADM, TRPC6, NPPB, AGT, AGTR1, EDN1
26valsartan44 59 28 1111.9REN, NPPB, EDN1, AGTR1, AGT, ACE
27amlodipine44 49 11 2411.8CYP1A1, REN, ACE, AGT, AGTR1, NPPB
28digoxin44 49 59 11 2412.8ACE, NPPB, REN, AGTR1, DNAH8
29perindopril44 49 1110.8AGTR1, ACE, VWF, REN, NPPB, AGT
30isoproterenol44 119.8AGTR1, VWF, CYP1A1, CHGA, ADM
31thromboxane a244 249.7AGTR1, APOH, VWF, ADM, EDN1, AGT
32ang ii448.7EDN1, ADM, ACE, REN, AGT, AGTR1
33cgmp44 289.6EDN1, NPPB, AGT, REN, ADM, AGTR1
34l-nmma448.6ADM, NPPB, EDN1, AGT, AGTR1
35carvedilol44 49 28 1111.6NPPB, EDN1, AGTR1, CYP1A1, REN, ACE
36haloperidol44 28 2 49 1112.5AGTR1, NPPB, AGT, REN, CHGA, CYP1A1
37sodium nitroprusside448.3NPPB, ADM, AGTR1, DNAH8, REN, EDN1
38losartan44 49 28 1111.2ADM, ACE, VWF, REN, AGT, EDN1
39nifedipine44 49 28 1111.1CYP1A1, ACE, CHGA, AGT, AGTR1, EDN1
40enalapril44 49 1110.1AGT, ACE, REN, NPPB, EDN1, AGTR1
41ouabain44 119.0EPO, CYP1A1, EDN1, DNAH8, NPPB
42indomethacin44 59 28 1111.0NPPB, CYP1A1, DNAH8, REN, ADM, EDN1
43prostacyclin447.7NPPB, APOH, EDN1, AGTR1, ADM, ACE
44epinephrine44 11 249.4VWF, REN, DNAH8, CHGA, AGT, AGTR1
45acetylcholine44 49 28 11 2411.3VWF, CHGA, ADM, AGT, AGTR1, EDN1
46nitric oxide44 11 249.0CHGA, TRPC3, AGT, AGTR1, ADM, ACE
47arginine446.7AGT, DNAH8, CYP1A1, REN, VWF, ADM
48vegf446.4AGTR1, EDN1, NPPB, APOH, AGT, CHGA
49calcium44 49 11 249.1NPPB, ADAMTS13, ACE, VWF, REN, TRPC3
50creatinine445.7APOH, NPPB, EDN1, AGTR1, AGT, CHGA

GO Terms for genes affiliated with Malignant Hypertension

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16Gene Ontology
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Cellular components related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056156.9ADM, APOH, NPPB, EDN1, AGT, EPO
2extracellular regionGO:0055766.6EDN1, AGT, CHGA, EPO, REN, VWF

Biological processes related to Malignant Hypertension according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.2AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.2AGT, AGTR1
3peptide catabolic processGO:04317110.2ACE, ADAMTS13
4regulation of renal sodium excretionGO:03581310.2AGT, AGTR1
5positive regulation of cholesterol esterificationGO:01087310.2AGT, AGTR1
6regulation of renal output by angiotensinGO:00201910.1AGT, ACE
7negative regulation of smooth muscle cell apoptotic processGO:03439210.1APOH, EDN1
8regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.1AGTR1, ACE
9low-density lipoprotein particle remodelingGO:03437410.1AGTR1, AGT
10positive regulation of cellular protein metabolic processGO:03227010.1AGTR1, AGT
11artery smooth muscle contractionGO:01482410.0AGT, EDN1
12positive regulation of cardiac muscle hypertrophyGO:01061310.0EDN1, AGT
13positive regulation of heart rateGO:01046010.0EDN1, ADM
14renin-angiotensin regulation of aldosterone productionGO:00201810.0REN, AGT, AGTR1
15body fluid secretionGO:00758910.0NPPB, EDN1
16positive regulation of urine volumeGO:03581010.0NPPB, EDN1
17angiotensin maturationGO:0020039.9ACE, REN, AGT
18maternal process involved in parturitionGO:0601379.9EDN1, CYP1A1
19negative regulation of blood coagulationGO:0301959.9APOH, EDN1
20regulation of vasodilationGO:0423129.9ACE, AGTR1, NPPB
21positive regulation of renal sodium excretionGO:0358159.8NPPB, EDN1, AGT
22elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.8AGTR1, EDN1
23positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
24elevation of cytosolic calcium ion concentrationGO:0072049.6EDN1, AGTR1, TRPC6, ADM
25response to woundingGO:0096119.6CYP1A1, VWF, ADM
26kidney developmentGO:0018229.6ACE, REN, AGT, AGTR1
27platelet activationGO:0301689.5ADAMTS13, VWF, TRPC3, TRPC6
28regulation of vasoconstrictionGO:0192299.5ACE, AGT, AGTR1, EDN1
29response to vitamin AGO:0331899.4EPO, CYP1A1
30response to salt stressGO:0096519.4EPO, AGT
31blood coagulation, intrinsic pathwayGO:0075979.4VWF, APOH
32response to hyperoxiaGO:0550939.3EPO, CYP1A1
33regulation of blood pressureGO:0082179.3NPPB, CHGA, REN, ACE
34response to testosterone stimulusGO:0335749.2EPO, EDN1
35agingGO:0075689.0AGT, EPO, CYP1A1, ADM
36response to lipopolysaccharideGO:0324968.7EDN1, EPO, CYP1A1, REN, ADM

Molecular functions related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.9AGTR1, ACE
2acetyltransferase activator activityGO:0106989.9AGTR1, AGT
3inositol 1,4,5 trisphosphate bindingGO:0706799.8TRPC3, TRPC6
4store-operated calcium channel activityGO:0152799.6TRPC6, TRPC3
5hormone activityGO:0051798.5ADM, EPO, AGT, EDN1, NPPB
6protein bindingGO:0055156.5EDN1, AGTR1, AGT, TRPC6, TRPC3, EPO

Products for genes affiliated with Malignant Hypertension

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Sources for Malignant Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet