MCID: MLG069
MIFTS: 63

Malignant Hypertension malady

Genetic diseases, Cardiovascular diseases, Blood diseases, Rare diseases categories

Summaries for Malignant Hypertension

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66Wikipedia, 34MalaCards
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Wikipedia:66 A hypertensive emergency (formerly called \"malignant hypertension\") is hypertension (high blood... more...

MalaCards: Malignant Hypertension, also known as hypertension malignant, is related to hypertension and purpura. An important gene associated with Malignant Hypertension is ADM (adrenomedullin), and among its related pathways are Effects of PIP2 hydrolysis and TRP channels. The drugs trimethaphan camsylate and captopril and the compounds aliskiren and saralasin have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and liver, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Malignant Hypertension

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9Disease Ontology, 63UMLS, 46Novoseek, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:



Aliases & Descriptions:

malignant hypertension 9 63
hypertension malignant 46


External Ids:

Disease Ontology9 DOID:10824
MeSH36 D006974
NCIt41 C3118

Related Diseases for Malignant Hypertension

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18GeneCards, 19GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension malignant hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Malignant Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.6EDN1, ADM, REN, ACE, DNAH8, NPPB
2purpura30.5ADAMTS13
3hemolytic-uremic syndrome30.4ADAMTS13, VWF
4nephrosclerosis30.4ADM, ACE, AGTR1
5phaeochromocytoma30.4ADM, CHGA
6conn's syndrome30.2AGTR1, REN, ADM
7adrenal adenoma30.2ADM, REN
8antiphospholipid syndrome30.2VWF, APOH, ADAMTS13
9hemolytic anemia30.2VWF, APOH, ADAMTS13
10vascular disease30.2APOH, VWF
11thrombocytopenia30.2VWF, APOH, ADAMTS13
12hypokalemia30.1REN, ACE, DNAH8
13central retinal vein occlusion30.0APOH
14hyperaldosteronism29.9REN, ACE, AGTR1
15primary pulmonary hypertension29.9EDN1, ADM, NPPB
16focal segmental glomerulosclerosis29.9ACE, AGTR1, TRPC6
17renal hypertension29.9EDN1, ADM, REN, ACE
18proteinuria29.8TRPC6, AGTR1, AGT, ACE, REN, ADAMTS13
19hyperglycemia29.8AGTR1, AGT, DNAH8, ACE
20essential hypertension29.8VWF, EDN1, ADM, REN, ACE, NPPB
21ischemia29.7EDN1, ADM, ADAMTS13, DNAH8, NPPB, AGT
22glomerulosclerosis29.7TRPC6, AGTR1, AGT, ACE, REN, ADM
23diabetic nephropathy29.7EDN1, VWF, ADM, REN, ACE, AGT
24diabetes mellitus29.5EDN1, VWF, REN, ACE, DNAH8, NPPB
25hypertensive encephalopathy10.4
26hypertensive retinopathy10.3
27glomerulonephritis10.3
28cerebritis10.3
29adenoma10.3
30papilledema10.3
31pyelonephritis10.3
32retinitis10.3
33scleroderma10.3
34pheochromocytoma10.3
35anuria10.2
36chronic pyelonephritis10.2
37thrombotic thrombocytopenic purpura10.2
38end stage renal failure10.2
39malignant hypertensive renal disease10.2
40paraganglioma10.2
41neuropathy10.2
42pancreatitis10.2
43uremia10.2
44periarteritis nodosa10.2
45blindness10.2
46fibromuscular dysplasia10.1REN
47congestive heart failure10.1REN
48hypoaldosteronism10.1REN
49thrombotic thrombocytopenic purpura, acquired10.1ADAMTS13
50mitral valve prolapse10.1AGTR1

Graphical network of the top 20 diseases related to Malignant Hypertension:



Diseases related to malignant hypertension

Symptoms for Malignant Hypertension

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Drugs & Therapeutics for Malignant Hypertension

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Genetic Tests for Malignant Hypertension

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Anatomical Context for Malignant Hypertension

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34MalaCards
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MalaCards organs/tissues related to Malignant Hypertension:

34
Kidney, Brain, Liver, Endothelial, Adrenal gland, Small intestine, Heart, Spinal cord, Spleen, Lymph node, Eye

Animal Models for Malignant Hypertension or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Malignant Hypertension:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.1ADM, REN, NPPB, AGT, TRPC6, EDN1
2MP:00053677.7EDN1, ADM, CHGA, REN, ACE, AGT
3MP:00053877.0VWF, ADM, ADAMTS13, REN, ACE, AGT
4MP:00053766.2ADM, APOH, VWF, EDN1, ADAMTS13, CHGA
5MP:00107686.1ADM, APOH, VWF, EDN1, ADAMTS13, CHGA
6MP:00053855.9TRPC3, EDN1, VWF, ADM, CHGA, REN

Publications for Malignant Hypertension

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53PubMed
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Articles related to Malignant Hypertension:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Diagnosis of malignant hypertension with ocular examination: a child case. (24168178)
2014
2
Malignant hypertension and interferon-beta: a case report. (24067346)
2013
3
Mortality and Cardiovascular Risk in Patients With a History of Malignant Hypertension: A Case-Control Study. (24373528)
2013
4
Intravitreal bevacizumab in persistent retinopathy secondary to malignant hypertension. (23964183)
2013
5
Telmisartan prevents excess-salt-induced exacerbated (malignant) hypertension in spontaneously hypertensive rats. (22927675)
2013
6
Malignant hypertension in patients treated with vascular endothelial growth factor inhibitors. (23458595)
2013
7
An Extra-adrenal Pheochromocytoma Presenting as Malignant Hypertension-A Report of two cases. (23905134)
2013
8
Malignant hypertension with an unusual presentation mimicking the immune mediated pulmonary renal syndrome. (23074127)
2012
9
Neonatal midaortic syndrome and renal artery atresia presenting as malignant hypertension. (22447383)
2012
10
Common genetic variants in the chromogranin a promoter are associated with renal injury in IgA nephropathy patients with malignant hypertension. (20113265)
2010
11
Increased TRPC3 expression in vascular endothelium of patients with malignant hypertension. (19136933)
2009
12
Malignant hypertension and acute aortic dissection associated with caffeine-based ephedra-free dietary supplements: a case report. (20181166)
2009
13
The renin-angiotensin system in malignant hypertension revisited: plasma renin activity, microangiopathic hemolysis, and renal failure in malignant hypertension. (17679041)
2007
14
Malignant hypertension, polycythemia, and paragangliomas. (16647420)
2006
15
Ophthalmoscopic findings in malignant hypertension. (16523002)
2006
16
Malignant hypertension with intestinal ischemia secondary to juxtaglomerular cell tumor. (16253738)
2005
17
A rare case of alveolar haemorrhage due to malignant hypertension. (16046511)
2005
18
Sudden sensorineural hearing loss after rapid reduction of blood pressure in malignant hypertension. (14763578)
2004
19
Malignant hypertension and cerebral haemorrhage in Seckel syndrome. (14564517)
2003
20
Malignant hypertension with a rare complication of pulmonary alveolar hemorrhage. (10644871)
2000
21
Outcome of patients with malignant hypertension and end-stage renal failure treated by long-term hemodialysis. (10702650)
1999
22
Malignant hypertension and paraganglioma in a 14-year-old girl. (9932276)
1999
23
Despite low plasma renin ACE inhibitor treatment causes recovery from acute renal failure in a patient with malignant hypertension. (9550666)
1998
24
Are vasopressin peripheral V1 receptors involved in the development of malignant hypertension and stroke in SHR-SPs? (8617411)
1995
25
Malignant hypertension is accompanied by marked alterations in chylomicron metabolism. (7498998)
1995
26
Malignant hypertension. (2040938)
1991
27
Phlebotomy for erythropoietin-associated malignant hypertension. (1673767)
1991
28
The survival of malignant hypertension in blacks, whites and Asians in Britain. (2338701)
1990
29
Malignant hypertension in women of childbearing age and its relation to the contraceptive pill. (3107691)
1987
30
Malignant hypertension due to a renin-secreting renal cell carcinoma--an ultrastructural and immunocytochemical study. (3536712)
1986
31
Fundus lesions in malignant hypertension. VI. Hypertensive choroidopathy. (3808599)
1986
32
Malignant hypertension in end-stage renal failure: hemodynamic and hormone status. (3913571)
1985
33
Plasma prolactin levels in patients with essential hypertension, malignant hypertension and secondary hypertension. (3889434)
1985
34
Vascular lesions and angiotensin in malignant hypertension in the absence of vasopressin. (6754178)
1982
35
Blood pressure in acute and chronic vasopressin excess: studies of malignant hypertension and the syndrome of inappropriate antidiuretic hormone secretion. (7207565)
1981
36
Analysis of 30 patients with malignant hypertension treated with hemodialysis. (6118966)
1981
37
Relief from malignant hypertension by treatment with captopril in a patient on maintenance hemodialysis. (7003235)
1980
38
Malignant hypertension and cigarette smoking. (427451)
1979
39
Use of the oral angiotensin I--converting enzyme inhibitor (captopril) in childhood malignant hypertension. (383935)
1979
40
Resolution of renal failure with malignant hypertension in scleroderma. Case report and review of the literature. (474603)
1979
41
Malignant hypertension in children secondary to chronic pyelonephritis: laboratory and radiologic indications for partial or total nephrectomy. (633491)
1978
42
Pathogenesis of malignant hypertension: experimental evidence from the renal hypertensive rat. (1192618)
1975
43
Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma. (178085)
1975
44
Malignant hypertension due to musculo-mucoid intimal hyperplasia of intrarenal arteries. Absence of renal fibrinoid necrosis. (48431)
1975
45
The unresolved nature of malignant hypertension. (4467901)
1974
46
Bilateral nephrectomy as a treatment of malignant hypertension. (4459310)
1974
47
Renomedullary antihypertensive function in accelerated (malignant) hypertension. Observations on renomedullary interstitial cells. (4108666)
1972
48
Oral diazoxide for malignant hypertension. (4113603)
1972
49
Malignant hypertension following the administration of cortisone in periarteritis nodosa. (14856504)
1951
50
Benign and Malignant Hypertension and Nephrosclerosis: A Clinical and Pathological Study. (19970253)
1936

Variations for Malignant Hypertension

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Expression for genes affiliated with Malignant Hypertension

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Hypertension

Search GEO for disease gene expression data for Malignant Hypertension.

Pathways for genes affiliated with Malignant Hypertension

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51PathCards, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 52PharmGKB, 31KEGG
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Compounds for genes affiliated with Malignant Hypertension

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46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Malignant Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 212)
idCompoundScoreTop Affiliating Genes
1aliskiren46 1210.3AGTR1, REN, ACE, AGT
2saralasin469.3AGTR1, AGT, ACE, REN
3eprosartan46 30 1211.3ACE, AGTR1, AGT, REN
4olmesartan46 30 1211.0REN, AGTR1, AGT, ACE
5fosinopril46 1210.0REN, AGTR1, NPPB, ACE
6lacidipine469.0EDN1, REN, ACE, AGTR1
7omapatrilat469.0EDN1, ADM, REN, ACE
8lisinopril46 52 25 1212.0AGTR1, AGT, NPPB, ACE, REN
9telmisartan46 30 1210.9AGTR1, NPPB, ACE, REN, AGT
10cilazapril46 129.9AGTR1, ACE, REN, EDN1
11candesartan46 52 30 1211.9AGTR1, AGT, NPPB, REN, ACE
12amlodipine46 52 25 1211.9ACE, AGTR1, AGT, NPPB, REN
13chymostatin468.7EDN1, ACE, AGT, REN, AGTR1
14irbesartan46 30 52 1211.7AGT, EDN1, REN, ACE, AGTR1
15enalaprilat468.7REN, ACE, NPPB, AGT, EDN1
16trandolapril46 129.7REN, ACE, AGTR1, NPPB, EDN1
17benazepril46 52 1210.7AGTR1, AGT, ACE, REN
18diltiazem46 30 52 1211.7EDN1, ACE, AGTR1, REN, AGT
19bisoprolol46 52 1210.7VWF, REN, ACE, NPPB
20digoxin46 62 52 25 1212.6REN, AGTR1, ACE, NPPB, DNAH8
21carvedilol46 52 30 1211.5REN, AGTR1, NPPB, ACE, ADM, EDN1
22nitroglycerin46 129.5ADM, REN, NPPB, EDN1, ACE, AGTR1
23phenylephrine46 30 25 1211.4EDN1, ADM, NPPB, AGT, AGTR1, TRPC6
24valsartan46 62 30 1211.4AGTR1, AGT, EDN1, REN, NPPB, ACE
25l-nmma468.4EDN1, ADM, AGT, AGTR1, NPPB
26cgmp46 309.4EDN1, ADM, REN, NPPB, AGT, AGTR1
27atenolol46 52 30 25 1212.4EDN1, REN, ACE, NPPB, AGT, AGTR1
28enalapril46 52 1210.4AGTR1, AGT, EDN1, NPPB, ACE, REN
29nifedipine46 30 52 1211.3CHGA, AGTR1, REN, ACE, AGT, EDN1
30quinapril46 52 1210.3VWF, REN, EDN1, ACE, AGTR1
31inositol 1,4,5 trisphosphate468.2CHGA, EDN1, TRPC6, TRPC3, ADM, AGT
32perindopril46 52 1210.2VWF, REN, ACE, AGT, AGTR1, NPPB
33captopril46 62 52 30 1212.1EDN1, ADM, REN, ACE, AGTR1, AGT
34ang ii468.1NPPB, AGT, AGTR1, REN, ADM, EDN1
35thromboxane a246 259.1ADM, APOH, AGT, AGTR1, VWF, EDN1
36sodium nitroprusside467.6REN, EDN1, ADM, AGTR1, VWF, NPPB
37isoproterenol46 128.5ADM, VWF, AGTR1, AGT, NPPB, REN
38cholesterol46 30 25 1210.3CHGA, AGT, VWF, APOH, ACE, REN
39losartan46 52 30 1210.3VWF, ADM, REN, ACE, NPPB, AGT
40lipid467.2AGT, NPPB, ACE, TRPC3, CHGA, ADM
41cyclosporin a46 30 629.2AGT, AGTR1, VWF, NPPB, DNAH8, ADAMTS13
42vegf467.2APOH, VWF, CHGA, ADM, EDN1, REN
43epinephrine46 25 129.0EDN1, VWF, ADM, CHGA, REN, DNAH8
44acetylcholine46 52 30 25 1210.8AGTR1, EDN1, VWF, AGT, NPPB, DNAH8
45prostacyclin466.7ADM, APOH, VWF, EDN1, ACE, NPPB
46arginine466.7AGT, DNAH8, REN, AGTR1, EDN1, VWF
47norepinephrine46 25 128.5ADM, CHGA, REN, ACE, DNAH8, VWF
48nitric oxide46 25 128.4ACE, REN, CHGA, ADM, APOH, VWF
49creatinine466.0APOH, ADM, ADAMTS13, VWF, CHGA, REN
50calcium46 52 25 128.4CHGA, ADAMTS13, APOH, VWF, EDN1, REN

GO Terms for genes affiliated with Malignant Hypertension

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17Gene Ontology
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Cellular components related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056157.2AGT, EDN1, APOH, ADM, ADAMTS13, REN
2extracellular regionGO:0055767.0VWF, ADM, CHGA, REN, ACE, NPPB

Biological processes related to Malignant Hypertension according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood vessel size by renin-angiotensinGO:00203410.1AGTR1, AGT
2positive regulation of NAD(P)H oxidase activityGO:03386410.1AGTR1, AGT
3regulation of renal sodium excretionGO:03581310.1AGTR1, AGT
4positive regulation of cholesterol esterificationGO:01087310.0AGT, AGTR1
5peptide catabolic processGO:04317110.0ADAMTS13, ACE
6low-density lipoprotein particle remodelingGO:03437410.0AGT, AGTR1
7regulation of renal output by angiotensinGO:00201910.0ACE, AGT
8positive regulation of cellular protein metabolic processGO:0322709.9AGTR1, AGT
9renin-angiotensin regulation of aldosterone productionGO:0020189.9AGTR1, AGT, REN
10regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.9ACE, AGTR1
11negative regulation of smooth muscle cell apoptotic processGO:0343929.9EDN1, APOH
12positive regulation of heart rateGO:0104609.8ADM, EDN1
13artery smooth muscle contractionGO:0148249.8AGT, EDN1
14negative regulation of angiogenesisGO:0165259.7APOH, NPPB, AGT
15angiotensin maturationGO:0020039.7AGT, ACE, REN
16positive regulation of cardiac muscle hypertrophyGO:0106139.7EDN1, AGT
17body fluid secretionGO:0075899.7NPPB, EDN1
18agingGO:0075689.6ADM, AGT, TRPC6
19negative regulation of blood coagulationGO:0301959.6EDN1, APOH
20regulation of vasodilationGO:0423129.6AGTR1, NPPB, ACE
21positive regulation of urine volumeGO:0358109.5EDN1, NPPB
22positive regulation of renal sodium excretionGO:0358159.5EDN1, NPPB, AGT
23response to lipopolysaccharideGO:0324969.5EDN1, ADM, REN
24positive regulation of macrophage derived foam cell differentiationGO:0107449.5AGTR1, AGT
25regulation of blood pressureGO:0082179.4CHGA, REN, ACE, NPPB
26positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:0514829.4AGTR1, EDN1
27blood coagulation, intrinsic pathwayGO:0075979.4APOH, VWF
28kidney developmentGO:0018229.3AGTR1, AGT, ACE, REN
29positive regulation of cytosolic calcium ion concentrationGO:0072049.1EDN1, ADM, AGTR1, TRPC6
30regulation of vasoconstrictionGO:0192299.0AGTR1, AGT, ACE, EDN1
31platelet activationGO:0301688.9VWF, ADAMTS13, TRPC6, TRPC3

Molecular functions related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1store-operated calcium channel activityGO:0152799.7TRPC3, TRPC6
2bradykinin receptor bindingGO:0317119.6ACE, AGTR1
3inositol 1,4,5 trisphosphate bindingGO:0706799.4TRPC3, TRPC6
4hormone activityGO:0051798.9AGT, NPPB, ADM, EDN1
5protein bindingGO:0055156.1EDN1, VWF, APOH, ADM, ADAMTS13, ACE

Products for genes affiliated with Malignant Hypertension

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Sources for Malignant Hypertension

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet