MCID: MLG069
MIFTS: 60

Malignant Hypertension malady

Summaries for Malignant Hypertension

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63Wikipedia, 32MalaCards
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Wikipedia:63 A hypertensive emergency (formerly called \"malignant hypertension\") is hypertension (high blood... more...

MalaCards: Malignant Hypertension, also known as hypertension malignant, is related to hypertension and renal hypertension. An important gene associated with Malignant Hypertension is ADM (adrenomedullin), and among its related pathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MicroRNAs in cardiomyocyte hypertrophy. The drugs captopril and diazoxide and the compounds captopril and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and endothelial, and related mouse phenotypes are muscle and renal/urinary system.

Aliases & Classifications for Malignant Hypertension

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8Disease Ontology, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

malignant hypertension 8 60
hypertension malignant 44


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Disease Ontology8 DOID:10824
NCIt39 C3118
MeSH34 D006974

Related Diseases for Malignant Hypertension

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17GeneCards, 18GeneDecks
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Diseases in the Hypertension family:

Benign Essential Hypertension Malignant Essential Hypertension
Essential Hypertension malignant hypertension
Familial Hypertension Hypertension, Essential 3
Hypertension, Essential 7 Hypertension, Essential 6
Hypertension, Essential 4 Hypertension, Essential 2
Hypertension, Essential 1 Hypertension, Essential 8
Hypertension, Essential 5

Diseases related to Malignant Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.8ADM, ACE, REN, DNAH8, AGT, AGTR1
2renal hypertension31.2ADM, ACE, EDN1, REN
3essential hypertension30.6AGTR1, AGT, TRPC3, REN, EDN1, NPPB
4hypertensive encephalopathy30.5EPO
5glomerulonephritis30.4AGTR1
6pheochromocytoma30.3ADM, CHGA
7adenoma30.3CHGA, DNAH8, CYP1A1, REN
8purpura30.3ADAMTS13
9anuria30.2ACE
10hemolytic-uremic syndrome30.2VWF, ADAMTS13
11nephrosclerosis30.2ACE, AGTR1, ADM
12neuropathy30.2DNAH8
13conn's syndrome30.2REN
14paraganglioma30.1CHGA
15uremia30.1VWF, EPO
16renovascular hypertension30.1ADM, AGTR1, REN, ACE
17lupus erythematosus30.0APOH
18hypokalemia30.0REN, DNAH8, ACE
19antiphospholipid syndrome30.0APOH, ADAMTS13, VWF
20adrenal adenoma30.0ADM, CHGA, AGTR1, REN
21thrombocytopenia30.0VWF, ADAMTS13, EPO, APOH
22hemolytic anemia30.0APOH, ADAMTS13, VWF, EPO
23proteinuria30.0AGT, APOH, EDN1, AGTR1, TRPC6, REN
24vascular disease30.0EDN1, AGTR1, AGT, DNAH8, VWF, ACE
25retinal vein occlusion29.8APOH
26obesity29.8AGT
27cushing's syndrome29.8REN
28polycythemia29.8EPO
29central retinal vein occlusion29.8APOH
30arteriosclerosis29.8ADM, EDN1
31hyperaldosteronism29.8AGTR1, ACE, REN
32vasculitis29.8APOH, VWF
33focal segmental glomerulosclerosis29.8AGTR1, TRPC6, ACE
34hypertensive heart disease29.8NPPB, ACE, AGTR1
35primary pulmonary hypertension29.8EDN1, ADM, NPPB, AGT
36hyperglycemia29.8AGTR1, AGT, DNAH8, ACE
37systemic lupus erythematosus29.8ADAMTS13, CYP1A1, VWF, APOH
38ischemia29.8DNAH8, AGT, ADAMTS13, ADM, NPPB, EDN1
39ischemic heart disease29.8NPPB, EDN1, AGTR1, AGT, ACE, ADM
40diabetic nephropathy29.8REN, EDN1, AGTR1, AGT, EPO, VWF
41diabetes mellitus29.8ACE, VWF, REN, DNAH8, AGT, AGTR1
42malignant secondary hypertension10.5
43malignant essential hypertension10.4
44malignant hypertensive renal disease10.4
45hypertensive retinopathy10.4
46cerebritis10.3
47chronic pyelonephritis10.2
48papilledema10.2
49pyelonephritis10.2
50retinitis10.2

Graphical network of the top 20 diseases related to Malignant Hypertension:



Diseases related to malignant hypertension

Clinical Features for Malignant Hypertension

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Drugs & Therapeutics for Malignant Hypertension

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Malignant Hypertension

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Anatomical Context for Malignant Hypertension

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32MalaCards
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MalaCards organs/tissues related to Malignant Hypertension:

32
Kidney, Brain, Endothelial, Liver, Adrenal gland, Skin, Pancreas, Small intestine, Heart, Spinal cord, Spleen, Lymph node, Bone, Eye

Animal Models for Malignant Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.7EDN1, AGT, TRPC6, REN, ADM, NPPB
2MP:00053677.9EDN1, AGTR1, AGT, CHGA, REN, ACE
3MP:00053767.8APOH, AGTR1, AGT, TRPC3, REN, VWF
4MP:00053877.3AGTR1, AGT, TRPC3, CYP1A1, REN, VWF
5MP:00107685.4CHGA, AGT, AGTR1, EDN1, APOH, TRPC3
6MP:00053855.4ADM, NPPB, EDN1, AGTR1, AGT, CHGA

Publications for Malignant Hypertension

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50PubMed
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Articles related to Malignant Hypertension:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Atypical hemolytic-uremic syndrome in a child presenting with malignant hypertension. (21708810)
2013
2
Persistent macrovascular and microvascular dysfunction in patients with malignant hypertension. (21263115)
2011
3
Acute renal failure secondary to malignant hypertension induced thrombotic microangiopathy. (20635021)
2010
4
Long-term renal survival in malignant hypertension. (20299339)
2010
5
Malignant hypertension and acute aortic dissection associated with caffeine-based ephedra-free dietary supplements: a case report. (20181166)
2009
6
Kidney involvement in thrombotic thrombocytopenic purpura and malignant hypertension. (19735502)
2009
7
A comparison of hinge craniotomy and decompressive craniectomy for the treatment of malignant intracranial hypertension: early clinical and radiographic analysis. (19485719)
2009
8
Malignant hypertension in IgA nephropathy was not associated with background pathological phenotypes of glomerular lesions. (18603547)
2008
9
Aldosterone receptor antagonism alleviates proteinuria, but not malignant hypertension, in Cyp1a1-Ren2 transgenic rats. (17715265)
2007
10
MRI changes in thrombotic microangiopathy secondary to malignant hypertension. (17441841)
2007
11
Malignant hypertension, polycythemia, and paragangliomas. (16647420)
2006
12
Unilateral malignant hypertensive retinopathy. (16924026)
2006
13
Thrombotic microangiopathy in malignant hypertension and hemolytic uremic syndrome (HUS)/ thrombotic thrombocytopenic purpura (TTP): can we differentiate one from the other? (15969259)
2005
14
Diagnostic challenges associated with a complex case of cystic phaeochromocytoma presenting with malignant hypertension, microangiopathic haemolysis and acute renal failure. (15769821)
2005
15
Malignant hypertension with a rare complication of pulmonary alveolar hemorrhage. (10644871)
2000
16
Plasma adrenomedullin and natriuretic peptides in patients with essential or malignant hypertension. (10221353)
1999
17
Haematospermia associated with malignant hypertension. (10448405)
1999
18
Cerebellar infarction as a complication of malignant hypertension. (9759993)
1998
19
Malignant hypertension in young women is related to previous hypertension in pregnancy, not oral contraception. (9349449)
1997
20
Malignant hypertension is accompanied by marked alterations in chylomicron metabolism. (7498998)
1995
21
The failure of malignant hypertension to decline: a survey of 24 years' experience in a multiracial population in England. (7868878)
1994
22
Cushing's syndrome--a reversible cause of malignant hypertension. (8191340)
1993
23
A case of malignant hypertension and scleroderma after cosmetic surgery. (1865582)
1991
24
The renal histopathology of essential malignant hypertension in black South Africans. (1876949)
1991
25
Plasma immunoreactive endothelin-1 in experimental malignant hypertension. (1860718)
1991
26
Etiology and management of malignant hypertension. (3168428)
1988
27
Mechanism and treatment of malignant hypertension. (3293138)
1988
28
Malignant arterial hypertension. Relationship between blood pressure control and renal function during long-term observation of patients with malignant nephrosclerosis. (3453383)
1987
29
Factors influencing mortality in malignant hypertension. (2856750)
1985
30
Prospective measurement of glomerular filtration rate and effective renal plasma flow during treatment of malignant essential hypertension. (6494086)
1984
31
Successful surgical treatment of malignant hypertension due to metastatic seminoma. (6675664)
1983
32
Embolization and angioplasty to relieve malignant hypertension and azotemia in a renal transplant patient. (6220804)
1982
33
Stroke-prone spontaneously hypertensive rats as an experimental model of malignant hypertension. A pathological study. (7072143)
1982
34
Renal revascularization as treatment for malignant hypertension. (7417891)
1980
35
Response of malignant hypertension with refractory cardiac failure to captopril: A case report. (6996155)
1980
36
Perforaton of small intestine after treatment for malignant hypertension. (6105286)
1980
37
Blindness after treatment for malignant hypertension. (476403)
1979
38
Blindness and malignant hypertension. (90906)
1979
39
Effects of saline drinking on malignant course of renal hypertension in rats. (1266989)
1976
40
Renin-angiotensin system in an infant with malignant renovascular hypertension. (939701)
1976
41
Malignant hypertension with hypokalemia in a patient with renin-producing pulmonary carcinoma. (178085)
1975
42
The syndrome of malignant hypertension. (1141742)
1975
43
Bilateral nephrectomy as a treatment of malignant hypertension. (4459310)
1974
44
Oral diazoxide in uncontrolled malignant hypertension. (4444609)
1974
45
Malignant hypertension. (4155658)
1974
46
Bilateral nephrectomy: its role in management of the malignant hypertension of end-stage renal disease. (4940925)
1971
47
Vascular lesions of malignant essential hypertension. (5567174)
1971
48
The relation of malignant hypertension to periarteritis nodosa in humans. (13271999)
1955
49
Clinical pathologic conference; hypertension, malignant phase, characterized by cardiac hypertrophy, marked, predominantly left ventricle; hyperplastic arteriosclerosis and malignant nephrosclerosis. (14779219)
1950
50
Pregnancy following lumbodorsal splanchnicectomy for essential and malignant hypertension and hypertension associated with chronic pyelonephritis. (20241256)
1947

Genetic Variations for Malignant Hypertension

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Expression for genes affiliated with Malignant Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Hypertension

Search GEO for disease gene expression data for Malignant Hypertension.

Pathways for genes affiliated with Malignant Hypertension

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49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Malignant Hypertension

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44Novoseek, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank, 24HMDB, 2BitterDB
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Compounds related to Malignant Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 215)
idCompoundScoreTop Affiliating Genes
1captopril44 28 49 59 1114.0ADM, REN, EDN1
2aliskiren44 1110.6AGTR1, AGT, REN, ACE
3saralasin449.5AGT, REN, ACE, AGTR1
4benazepril44 1110.5AGT, REN, ACE, AGTR1
5eprosartan44 28 1111.5ACE, REN, AGT, AGTR1
6lacidipine449.5EDN1, AGTR1, REN, ACE
7omapatrilat449.4REN, ADM, ACE, EDN1
8cilazapril44 1110.4EDN1, AGTR1, REN, ACE
9lisinopril44 11 2411.3AGTR1, AGT, REN, ACE, NPPB
10atenolol44 28 49 11 2413.3NPPB, AGTR1, AGT, REN, ACE
11telmisartan44 28 1111.2ACE, REN, AGT, NPPB, AGTR1
12fosinopril44 1110.2AGTR1, REN, NPPB, ACE
13trandolapril44 1110.2NPPB, AGTR1, REN, EDN1, ACE
14chymostatin449.2AGTR1, EDN1, AGT, REN, ACE
15bisoprolol44 49 1111.2REN, VWF, ACE, NPPB
16candesartan44 28 1111.2ACE, AGT, REN, AGTR1, NPPB
17enalaprilat449.2AGT, EDN1, NPPB, REN, ACE
18olmesartan44 28 1111.1ACE, REN, AGT, AGTR1
19cyclosporin a44 28 5911.1DNAH8, NPPB, ADAMTS13, ADM, EDN1
20diltiazem44 28 1111.1REN, ACE, AGT, AGTR1, EDN1
21norepinephrine44 11 2411.1ADM, CYP1A1, DNAH8, CHGA
22inositol 1,4,5 trisphosphate449.0ADM, EDN1, CHGA, TRPC6, TRPC3
23quinapril44 1110.0ACE, VWF, REN, AGTR1, EDN1
24nitroglycerin44 1110.0NPPB, AGTR1, REN, ACE, ADM, EDN1
25phenylephrine44 28 11 2411.9ADM, TRPC6, NPPB, AGT, AGTR1, EDN1
26valsartan44 59 28 1111.9REN, NPPB, EDN1, AGTR1, AGT, ACE
27amlodipine44 49 11 2411.8CYP1A1, REN, ACE, AGT, AGTR1, NPPB
28digoxin44 49 59 11 2412.8ACE, NPPB, REN, AGTR1, DNAH8
29perindopril44 49 1110.8AGTR1, ACE, VWF, REN, NPPB, AGT
30isoproterenol44 119.8AGTR1, VWF, CYP1A1, CHGA, ADM
31thromboxane a244 249.7AGTR1, APOH, VWF, ADM, EDN1, AGT
32ang ii448.7EDN1, ADM, ACE, REN, AGT, AGTR1
33cgmp44 289.6EDN1, NPPB, AGT, REN, ADM, AGTR1
34l-nmma448.6ADM, NPPB, EDN1, AGT, AGTR1
35carvedilol44 49 28 1111.6NPPB, EDN1, AGTR1, CYP1A1, REN, ACE
36haloperidol44 28 2 49 1112.5AGTR1, NPPB, AGT, REN, CHGA, CYP1A1
37sodium nitroprusside448.3NPPB, ADM, AGTR1, DNAH8, REN, EDN1
38losartan44 49 28 1111.2ADM, ACE, VWF, REN, AGT, EDN1
39nifedipine44 49 28 1111.1CYP1A1, ACE, CHGA, AGT, AGTR1, EDN1
40enalapril44 49 1110.1AGT, ACE, REN, NPPB, EDN1, AGTR1
41ouabain44 119.0EPO, CYP1A1, EDN1, DNAH8, NPPB
42indomethacin44 59 28 1111.0NPPB, CYP1A1, DNAH8, REN, ADM, EDN1
43prostacyclin447.7NPPB, APOH, EDN1, AGTR1, ADM, ACE
44epinephrine44 11 249.4VWF, REN, DNAH8, CHGA, AGT, AGTR1
45acetylcholine44 49 28 11 2411.3VWF, CHGA, ADM, AGT, AGTR1, EDN1
46nitric oxide44 11 249.0CHGA, TRPC3, AGT, AGTR1, ADM, ACE
47arginine446.7AGT, DNAH8, CYP1A1, REN, VWF, ADM
48vegf446.4AGTR1, EDN1, NPPB, APOH, AGT, CHGA
49calcium44 49 11 249.1NPPB, ADAMTS13, ACE, VWF, REN, TRPC3
50creatinine445.7APOH, NPPB, EDN1, AGTR1, AGT, CHGA

GO Terms for genes affiliated with Malignant Hypertension

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16Gene Ontology
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Cellular components related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056156.9ADM, APOH, NPPB, EDN1, AGT, EPO
2extracellular regionGO:0055766.6EDN1, AGT, CHGA, EPO, REN, VWF

Biological processes related to Malignant Hypertension according to GeneCards/GeneDecks:

(show all 36)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:03386410.2AGTR1, AGT
2regulation of blood vessel size by renin-angiotensinGO:00203410.2AGT, AGTR1
3peptide catabolic processGO:04317110.2ACE, ADAMTS13
4regulation of renal sodium excretionGO:03581310.2AGT, AGTR1
5positive regulation of cholesterol esterificationGO:01087310.2AGT, AGTR1
6regulation of renal output by angiotensinGO:00201910.1AGT, ACE
7negative regulation of smooth muscle cell apoptotic processGO:03439210.1APOH, EDN1
8regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.1AGTR1, ACE
9low-density lipoprotein particle remodelingGO:03437410.1AGTR1, AGT
10positive regulation of cellular protein metabolic processGO:03227010.1AGTR1, AGT
11artery smooth muscle contractionGO:01482410.0AGT, EDN1
12positive regulation of cardiac muscle hypertrophyGO:01061310.0EDN1, AGT
13positive regulation of heart rateGO:01046010.0EDN1, ADM
14renin-angiotensin regulation of aldosterone productionGO:00201810.0REN, AGT, AGTR1
15body fluid secretionGO:00758910.0NPPB, EDN1
16positive regulation of urine volumeGO:03581010.0NPPB, EDN1
17angiotensin maturationGO:0020039.9ACE, REN, AGT
18maternal process involved in parturitionGO:0601379.9EDN1, CYP1A1
19negative regulation of blood coagulationGO:0301959.9APOH, EDN1
20regulation of vasodilationGO:0423129.9ACE, AGTR1, NPPB
21positive regulation of renal sodium excretionGO:0358159.8NPPB, EDN1, AGT
22elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:0514829.8AGTR1, EDN1
23positive regulation of macrophage derived foam cell differentiationGO:0107449.8AGTR1, AGT
24elevation of cytosolic calcium ion concentrationGO:0072049.6EDN1, AGTR1, TRPC6, ADM
25response to woundingGO:0096119.6CYP1A1, VWF, ADM
26kidney developmentGO:0018229.6ACE, REN, AGT, AGTR1
27platelet activationGO:0301689.5ADAMTS13, VWF, TRPC3, TRPC6
28regulation of vasoconstrictionGO:0192299.5ACE, AGT, AGTR1, EDN1
29response to vitamin AGO:0331899.4EPO, CYP1A1
30response to salt stressGO:0096519.4EPO, AGT
31blood coagulation, intrinsic pathwayGO:0075979.4VWF, APOH
32response to hyperoxiaGO:0550939.3EPO, CYP1A1
33regulation of blood pressureGO:0082179.3NPPB, CHGA, REN, ACE
34response to testosterone stimulusGO:0335749.2EPO, EDN1
35agingGO:0075689.0AGT, EPO, CYP1A1, ADM
36response to lipopolysaccharideGO:0324968.7EDN1, EPO, CYP1A1, REN, ADM

Molecular functions related to Malignant Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.9AGTR1, ACE
2acetyltransferase activator activityGO:0106989.9AGTR1, AGT
3inositol 1,4,5 trisphosphate bindingGO:0706799.8TRPC3, TRPC6
4store-operated calcium channel activityGO:0152799.6TRPC6, TRPC3
5hormone activityGO:0051798.5ADM, EPO, AGT, EDN1, NPPB
6protein bindingGO:0055156.5EDN1, AGTR1, AGT, TRPC6, TRPC3, EPO

Products for genes affiliated with Malignant Hypertension

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Sources for Malignant Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet