MCID: MLG069
MIFTS: 49

Malignant Hypertension

Categories: Genetic diseases, Rare diseases, Cardiovascular diseases, Blood diseases

Aliases & Classifications for Malignant Hypertension

MalaCards integrated aliases for Malignant Hypertension:

Name: Malignant Hypertension 12 14 69
Hypertension, Malignant 41
Hypertension Malignant 51

Classifications:



External Ids:

Disease Ontology 12 DOID:10824
MeSH 41 D006974
NCIt 46 C3118
UMLS 69 C0020540

Summaries for Malignant Hypertension

MalaCards based summary : Malignant Hypertension, also known as hypertension, malignant, is related to malignant essential hypertension and malignant secondary hypertension. An important gene associated with Malignant Hypertension is REN (Renin), and among its related pathways/superpathways are p70S6K Signaling and Peptide hormone metabolism. The drugs Atorvastatin Calcium and Diazoxide have been mentioned in the context of this disorder. Affiliated tissues include kidney, colon and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Malignant Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Malignant Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 malignant essential hypertension 32.0 ACE REN
2 malignant secondary hypertension 31.5 EDN1 REN
3 malignant renovascular hypertension 31.4 EDN1 REN
4 hypertensive retinopathy 30.5 ACE REN
5 nephrosclerosis 29.6 ACE ADAMTS13 AGTR1
6 hypertensive nephropathy 29.5 ACE AGTR1
7 syndrome of inappropriate antidiuretic hormone 29.5 ACE NPPA
8 hypokalemia 29.4 ACE REN
9 end stage renal failure 29.4 ACE AGT AGTR1
10 acute kidney failure 29.1 ADAMTS13 NPPA REN
11 conn's syndrome 29.1 ACE AGTR1 NPPA REN
12 anuria 29.0 ACE AGT AGTR1 REN
13 vascular disease 29.0 ACE EDN1 REN
14 microvascular complications of diabetes 3 28.9 ACE AGT AGTR1
15 fibromuscular dysplasia 28.6 ACE AGT AGTR1 REN
16 renal dysplasia 28.5 ACE AGT AGTR1 REN
17 ischemic optic neuropathy 28.0 ACE AGT AGTR1 EDN1
18 renal hypertension 27.8 ACE ADM AGTR1 EDN1 REN
19 kidney disease 27.7 ACE AGTR1 EDN1 NPPA REN
20 arteries, anomalies of 27.6 ACE AGT AGTR1 EDN1 REN
21 heart disease 27.2 ACE ADM AGTR1 EDN1 NPPA REN
22 hypertension, essential 26.8 ACE ADM AGT AGTR1 EDN1 NPPA
23 malignant hypertensive renal disease 12.0
24 hemolytic uremic syndrome, atypical 1 11.1
25 hyporeninemic hypoaldosteronism 10.4 ACE REN
26 renal artery obstruction 10.4 ACE REN
27 hypertension, diastolic 10.4 ACE REN
28 atrial septal defect 4 10.4 ACE REN
29 orthostatic proteinuria 10.3 ACE REN
30 anterolateral myocardial infarction 10.3 ACE NPPA
31 vasculogenic impotence 10.2 ACE NPPA
32 postural hypotension 10.2 NPPA REN
33 ureteral disease 10.2 ACE REN
34 congenital hepatic fibrosis 10.2 AGTR1 REN
35 pseudohyperkalemia, familial, 2, due to red cell leak 10.2 ACE REN
36 pediatric hypertension 10.2 ACE AGT
37 mitral valve insufficiency 10.1 ACE NPPA
38 aortic valve disease 1 10.1 ACE REN
39 hyperaldosteronism, familial, type i 10.1 AGT REN
40 pericardial effusion 10.1 NPPA REN
41 hypoaldosteronism 10.0 ACE NPPA REN
42 pure autonomic failure 10.0 ACE NPPA REN
43 meningococcal infection 10.0 AGT AGTR1
44 perinephritis 10.0 EDN1 REN
45 iga glomerulonephritis 10.0 ACE AGTR1 REN
46 encephalopathy 10.0
47 gitelman syndrome 10.0 AGT REN
48 stroke, ischemic 9.9 ACE AGTR1 REN
49 hypertensive encephalopathy 9.9
50 interstitial nephritis 9.9 ACE AGT REN

Graphical network of the top 20 diseases related to Malignant Hypertension:



Diseases related to Malignant Hypertension

Symptoms & Phenotypes for Malignant Hypertension

MGI Mouse Phenotypes related to Malignant Hypertension:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.95 ADM REN AGT AGTR1 ACE EDN1
2 homeostasis/metabolism MP:0005376 9.92 ADM REN AGT AGTR1 ACE EDN1
3 hematopoietic system MP:0005397 9.85 NPPA ADM REN AGTR1 ACE ADAMTS13
4 immune system MP:0005387 9.73 ADAMTS13 ADM REN AGT AGTR1 ACE
5 mortality/aging MP:0010768 9.7 ADM REN AGT AGTR1 ACE EDN1
6 muscle MP:0005369 9.35 ADM REN AGT EDN1 NPPA
7 renal/urinary system MP:0005367 9.17 ADM REN AGT AGTR1 ACE EDN1

Drugs & Therapeutics for Malignant Hypertension

Drugs for Malignant Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Atorvastatin Calcium Phase 3 134523-03-8
2
Diazoxide Approved Phase 2 364-98-7 3019
3
Choline Approved, Nutraceutical Phase 2 62-49-7 305
4 Antihypertensive Agents Phase 2
5 Antimetabolites Phase 2
6 Gastrointestinal Agents Phase 2
7 Hypolipidemic Agents Phase 2
8 Lipid Regulating Agents Phase 2
9 Nootropic Agents Phase 2
10 Vasodilator Agents Phase 2
11
Bevacizumab Approved, Investigational 216974-75-3
12 Angiogenesis Inhibitors
13 Angiogenesis Modulating Agents
14 Cola Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Stenting in Renal Dysfunction Caused by Atherosclerotic Renal Artery Stenosis Completed NCT00150943 Phase 3
2 Diazoxide Choline in Hypertriglyceridemia Completed NCT00696475 Phase 2 Diazoxide choline;Diazoxide choline;Diazoxide choline;Placebo
3 Single Incision Laparoscopy Completed NCT00616616
4 Study of Microcirculatory Effects of Bevacizumab in Patients Treated for Metastatic Colon Cancer or Glioblastoma Active, not recruiting NCT01810744
5 Disc Edema in Patients With Chronic Kidney Disease Withdrawn NCT00769834

Search NIH Clinical Center for Malignant Hypertension

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: hypertension, malignant

Genetic Tests for Malignant Hypertension

Anatomical Context for Malignant Hypertension

MalaCards organs/tissues related to Malignant Hypertension:

38
Kidney, Colon, Brain, Liver, Endothelial, Adrenal Gland, T Cells

Publications for Malignant Hypertension

Articles related to Malignant Hypertension:

(show top 50) (show all 565)
# Title Authors Year
1
Orbital haematoma in malignant hypertension. ( 28173968 )
2017
2
Response to: The Cause of the Arteriolar Injury in Malignant Hypertension. ( 28985311 )
2017
3
Malignant Hypertension Complicated By Renal Thrombotic Micro Angiopathy: Role Of Adam 13 Mutational Analyses. ( 29076694 )
2017
4
Malignant hypertension as a rare cause of thrombotic microangiopathy. ( 28596204 )
2017
5
Malignant Hypertension Revisited-Does This Still Exist? ( 28200072 )
2017
6
Thrombotic microangiopathy due to malignant hypertension complicated with late-onset bleeding after renal biopsy. ( 28679995 )
2017
7
The Etiology of Arteriolar Injury in Malignant Hypertension. ( 29059304 )
2017
8
Targeting renin-angiotensin system in malignant hypertension in atypical hemolytic uremic syndrome. ( 28356668 )
2017
9
Response of Renal Podocytes to Excessive Hydrostatic Pressure: a Pathophysiologic Cascade in a Malignant Hypertension Model. ( 29224013 )
2017
10
Predictors of 5-year outcomes in malignant phase hypertension: the West Birmingham Malignant Hypertension Registry. ( 28622157 )
2017
11
Malignant Hypertension with Thrombotic Microangiopathy. ( 27523008 )
2016
12
Takayasu arteritis presenting with malignant hypertension; a rare manifestation of a rare disease: a case report and review of the literature. ( 27216226 )
2016
13
First reported case of khat cardiomyopathy and malignant hypertension in Australia. ( 27981767 )
2016
14
A global amnesia associated with the specific variant of posterior reversible encephalopathy syndrome (PRES) that developed due to severe preeclampsia and malignant hypertension. ( 27099774 )
2016
15
IMAGES IN CLINICAL MEDICINE. Reversible Loss of Vision in Malignant Hypertension. ( 27050208 )
2016
16
CD4(+)CD25(+) T Cells in primary malignant hypertension related kidney injury. ( 27278520 )
2016
17
An unusual cause of malignant hypertension in young. ( 27728492 )
2016
18
Idiopathic midaortic syndrome with malignant hypertension in 3-year-old boy. ( 28018454 )
2016
19
Posterior reversible encephalopathy syndrome in malignant hypertension secondary to focal segmental glomerulosclerosis. ( 27535734 )
2016
20
Malignant hypertension-associated thrombotic microangiopathy following cocaine use. ( 26787585 )
2016
21
Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats. ( 27428043 )
2016
22
Fenofibrate Attenuates Malignant Hypertension by Suppression of the Renin-angiotensin System: A Study in Cyp1a1-Ren-2 Transgenic Rats. ( 27916218 )
2016
23
Intrarenal alterations of the angiotensin-converting enzyme type 2/angiotensin 1-7 complex of the renin-angiotensin system do not alter the course of malignant hypertension in Cyp1a1-Ren-2 transgenic rats. ( 26833491 )
2016
24
[OP.LB.02.05] A PATIENT WITH MALIGNANT HYPERTENSION SUCCESSFULLY TREATED WITH ECULIZUMAB AND BOSENTAN - SUGGESTIONS OF SIGNIFICANT INTERACTIONS OF COMPLEMENT AND THE ENDOTHELIN SYSTEM IN BLOOD PRESSURE CONTROL. ( 27508801 )
2016
25
Brain Natriuretic Peptide Counteracting the Renin-angiotensin-aldosterone System in Accelerated Malignant Hypertension. ( 27865304 )
2016
26
An ectopic renin-secreting adrenal corticoadenoma in a child with malignant hypertension. ( 26997629 )
2016
27
SPONTANEOUS BILATERAL HEMORRHAGIC CHOROIDAL DETACHMENTS ASSOCIATED WITH MALIGNANT HYPERTENSION. ( 27177073 )
2016
28
The endothelium as the common denominator in malignant hypertension and thrombotic microangiopathy. ( 26778772 )
2016
29
A case report of malignant hypertension in a young woman. ( 27389397 )
2016
30
Malignant Hypertensive Retinopathy in an Infant with Mid-Aortic Occlusion. ( 27795862 )
2016
31
Malignant hypertension: new aspects of an old clinical entity. ( 26658350 )
2016
32
Malignant Hypertension and Thrombotic Thrombocytopenic Purpura: False Friends. ( 26083445 )
2015
33
Bilateral exudative retinal detachment with choroidopathy in malignant hypertension. ( 27132968 )
2015
34
Characteristics of podocyte injury in malignant hypertensive nephropathy of rats (MSHRSP/Kpo strain). ( 26522148 )
2015
35
Tremendous result of bevacizumab in malignant hypertensive retinopathy. ( 25709280 )
2015
36
Malignant hypertension in lgA nephropathy. ( 25761814 )
2015
37
From malignant hypertension to hypertension-MOD: a modern definition for an old but still dangerous emergency. ( 26582411 )
2015
38
Differentiating malignant hypertension-induced thrombotic microangiopathy from thrombotic thrombocytopenic purpura. ( 26137201 )
2015
39
Does Anticomplement Therapy Have a Role in the Management of Malignant Hypertension? ( 26359936 )
2015
40
Basal transethmoidal encephalocele and malignant hypertension in a parturient with a seizure disorder. A case report. ( 25745752 )
2015
41
Malignant hypertension: a type of IgA nephropathy manifestation with poor prognosis. ( 25611832 )
2015
42
Malignant hypertensive retinopathy as a presenting sign of an occult dead fetus. ( 26082609 )
2015
43
Malignant Hypertension: Clinical Manifestations of 7 Cases. ( 25902134 )
2015
44
Severe visual loss caused by unrecognized malignant hypertension in a 15-year-old girl. ( 25868960 )
2015
45
Increasing trend in admissions for malignant hypertension and hypertensive encephalopathy in the United States. ( 25801877 )
2015
46
Candida-associated pseudo-aneurysm of the transplant renal artery presenting as malignant hypertension and managed successfully without nephrectomy. ( 26354578 )
2015
47
Atypical presentation of post infectious glomerulonephritis as malignant hypertension and thrombotic microangiopathy. ( 24701044 )
2014
48
Adaptive optics assisted visualization of thickened retinal arterial wall in a patient with controlled malignant hypertension. ( 25336903 )
2014
49
Malignant hypertension with thrombotic microangiopathy and persistent acute kidney injury (AKI). ( 25503954 )
2014
50
An 18-year-old female patient with malignant hypertension masked as thrombotic thrombocytopenia purpura? ( 24832123 )
2014

Variations for Malignant Hypertension

Expression for Malignant Hypertension

Search GEO for disease gene expression data for Malignant Hypertension.

Pathways for Malignant Hypertension

GO Terms for Malignant Hypertension

Cellular components related to Malignant Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ACE ADAMTS13 ADM AGT EDN1 NPPA
2 extracellular space GO:0005615 9.17 ACE ADAMTS13 ADM AGT EDN1 NPPA

Biological processes related to Malignant Hypertension according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.89 ADM AGT EDN1 NPPA
2 cell-cell signaling GO:0007267 9.85 ADM AGT EDN1
3 response to lipopolysaccharide GO:0032496 9.83 ADM EDN1 REN
4 response to hypoxia GO:0001666 9.82 ADM EDN1 NPPA
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.76 ADM AGT AGTR1 EDN1
6 female pregnancy GO:0007565 9.72 ADM AGT NPPA
7 kidney development GO:0001822 9.71 ACE AGT AGTR1 REN
8 regulation of cardiac conduction GO:1903779 9.68 AGT NPPA
9 calcium-mediated signaling GO:0019722 9.68 AGTR1 EDN1
10 positive regulation of endothelial cell migration GO:0010595 9.68 AGT EDN1
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.67 AGT EDN1
12 positive regulation of protein tyrosine kinase activity GO:0061098 9.67 ACE AGT
13 blood vessel remodeling GO:0001974 9.67 ACE AGT
14 positive regulation of reactive oxygen species metabolic process GO:2000379 9.66 AGT AGTR1
15 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.66 AGTR1 EDN1
16 positive regulation of blood vessel diameter GO:0097755 9.65 ADM AGT
17 positive regulation of cardiac muscle hypertrophy GO:0010613 9.65 AGT EDN1
18 vasoconstriction GO:0042310 9.64 AGT EDN1
19 peptide catabolic process GO:0043171 9.63 ACE ADAMTS13
20 positive regulation of cellular protein metabolic process GO:0032270 9.63 AGT AGTR1
21 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.62 AGT AGTR1
22 response to muscle stretch GO:0035994 9.62 EDN1 NPPA
23 cell growth involved in cardiac muscle cell development GO:0061049 9.61 AGT NPPA
24 amyloid-beta metabolic process GO:0050435 9.61 ACE REN
25 positive regulation of heart rate GO:0010460 9.61 ADM EDN1 NPPA
26 regulation of blood vessel diameter GO:0097746 9.6 ACE AGTR1
27 low-density lipoprotein particle remodeling GO:0034374 9.58 AGT AGTR1
28 positive regulation of renal sodium excretion GO:0035815 9.58 AGT EDN1
29 artery smooth muscle contraction GO:0014824 9.57 AGT EDN1
30 positive regulation of cholesterol esterification GO:0010873 9.56 AGT AGTR1
31 positive regulation of NAD(P)H oxidase activity GO:0033864 9.54 AGT AGTR1
32 regulation of blood vessel size GO:0050880 9.54 AGT EDN1 NPPA
33 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.52 AGT AGTR1
34 regulation of blood volume by renin-angiotensin GO:0002016 9.51 AGT REN
35 angiotensin maturation GO:0002003 9.5 ACE AGT REN
36 regulation of renal sodium excretion GO:0035813 9.49 AGT AGTR1
37 regulation of renal output by angiotensin GO:0002019 9.48 ACE AGT
38 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 ACE AGT AGTR1
39 renin-angiotensin regulation of aldosterone production GO:0002018 9.33 AGT AGTR1 REN
40 regulation of vasoconstriction GO:0019229 9.26 ACE AGT AGTR1 EDN1
41 regulation of blood pressure GO:0008217 9.02 ACE AGT EDN1 NPPA REN

Molecular functions related to Malignant Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.46 ADM EDN1 NPPA REN
2 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
3 hormone activity GO:0005179 8.92 ADM AGT EDN1 NPPA

Sources for Malignant Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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