Malignant Hyperthermia malady
Categories: Genetic diseases, Rare diseases, Neuronal diseases
Aliases & Descriptions for Malignant Hyperthermia:
Orphanet epidemiological data:51
Inheritance: Autosomal dominant; Age of onset: All ages; Age of death: normal life expectancy
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases
ICD10: 28 27
Rare neurological diseases
NIH Rare Diseases:45 Malignant hyperthermia (mh) is a severe reaction to certain gases used during anesthesia and/or a muscle relaxant used to temporarily paralyze a person during surgery. signs and symptoms of mh include marked hyperthermia, a rapid heart rate, rapid breathing, acidosis, muscle rigidity, and breakdown of muscle tissue (rhabdomyolysis). without prompt treatment, mh can be life-threatening. people who are at increased risk for this reaction are said to have mh susceptibility. susceptibility to mh may be caused by mutations in any of several genes and is inherited in an autosomal dominant manner. people with certain inherited muscle diseases (e.g., central core disease and multiminicore disease) also have mh susceptibility. last updated: 6/30/2014
MalaCards based summary: Malignant Hyperthermia, also known as anesthesia related hyperthermia, is related to gastric cancer and malignant hyperthermia susceptibility 1. An important gene associated with Malignant Hyperthermia is RYR1 (Ryanodine Receptor 1), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Calcium signaling pathway. The drugs dantrolene and dantrolene sodium have been mentioned in the context of this disorder. Affiliated tissues include heart, skeletal muscle and breast, and related mouse phenotypes are muscle and homeostasis/metabolism.
Disease Ontology:10 A genetic disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature.
Genetics Home Reference:23 Malignant hyperthermia is a severe reaction to particular drugs that are often used during surgery and other invasive procedures. Specifically, this reaction occurs in response to some anesthetic gases, which are used to block the sensation of pain, and with a muscle relaxant that is used to temporarily paralyze a person during a surgical procedure. If given these drugs, people at risk for malignant hyperthermia may experience muscle rigidity, breakdown of muscle fibers (rhabdomyolysis), a high fever, increased acid levels in the blood and other tissues (acidosis), and a rapid heart rate. Without prompt treatment, the complications of malignant hyperthermia can be life-threatening.
Wikipedia:68 Malignant hyperthermia (MH) or malignant hyperpyrexia is a rare life-threatening condition that is... more...
Drugs for Malignant Hyperthermia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show top 50) (show all 143)
Interventional clinical trials:(show top 50) (show all 66)
Search NIH Clinical Center for Malignant Hyperthermia
Inferred drug relations via UMLS65/NDF-RT43:
MalaCards organs/tissues related to Malignant Hyperthermia:33
Heart, Skeletal muscle, Breast, Bone, T cells, Brain, Kidney
Articles related to Malignant Hyperthermia:(show top 50) (show all 729)
Search GEO for disease gene expression data for Malignant Hyperthermia.
Pathways related to Malignant Hyperthermia according to GeneCards Suite gene sharing:(show all 21)
Cellular components related to Malignant Hyperthermia according to GeneCards Suite gene sharing:
Biological processes related to Malignant Hyperthermia according to GeneCards Suite gene sharing:
Molecular functions related to Malignant Hyperthermia according to GeneCards Suite gene sharing:
28ICD10 via Orphanet
37MESH via Orphanet
50OMIM via Orphanet
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
66UMLS via Orphanet