MCID: MLG097
MIFTS: 30

Malignant Mesenchymal Tumor malady

Rare diseases, Cancer diseases categories
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Summaries for Malignant Mesenchymal Tumor

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MalaCards: Malignant Mesenchymal Tumor, also known as malignant mesenchymoma, is related to rhabdomyosarcoma and sarcoma. An important gene associated with Malignant Mesenchymal Tumor is IGFBP3 (insulin-like growth factor binding protein 3), and among its related pathways are Translation Insulin regulation of translation and Integrated Pancreatic Cancer Pathway. The compounds exemestane and silymarin have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and prostate, and related mouse phenotypes are muscle and adipose tissue.

Aliases & Classifications for Malignant Mesenchymal Tumor

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

malignant mesenchymal tumor 43 62
malignant mesenchymoma 43


Related Diseases for Malignant Mesenchymal Tumor

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Malignant Mesenchymal Tumor:



Diseases related to malignant mesenchymal tumor

Symptoms for Malignant Mesenchymal Tumor

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Drugs & Therapeutics for Malignant Mesenchymal Tumor

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Search NIH Clinical Center for Malignant Mesenchymal Tumor

Genetic Tests for Malignant Mesenchymal Tumor

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Anatomical Context for Malignant Mesenchymal Tumor

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33MalaCards
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MalaCards organs/tissues related to Malignant Mesenchymal Tumor:

33
Liver, Breast, Prostate

Animal Models for Malignant Mesenchymal Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Malignant Mesenchymal Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1PTGS2, IGFBP3
2MP:00053759.0PTGS2, IGFBP3
3MP:00053708.8PTGS2, IGFBP3

Publications for Malignant Mesenchymal Tumor

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52PubMed
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Articles related to Malignant Mesenchymal Tumor:

(show all 18)
idTitleAuthorsYear
1
Local therapy is critical in localised pelvic rhabdomyosarcoma: experience of the International Society of Pediatric Oncology Malignant Mesenchymal Tumor (SIOP-MMT) committee. (22154650)
2012
2
Comparison of outcomes based on treatment algorithms for rhabdomyosarcoma of the bladder/prostate: combined results from the Children's Oncology Group, German Cooperative Soft Tissue Sarcoma Study, Italian Cooperative Group, and International Society of Pediatric Oncology Malignant Mesenchymal Tumors Committee. (20473932)
2011
3
Malignant mesenchymal tumor with leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, and osteosarcoma differentiation: case report and literature review. (21496258)
2011
4
Sparing strategy does not compromise prognosis in pediatric localized synovial sarcoma: experience of the International Society of Pediatric Oncology, Malignant Mesenchymal Tumors (SIOP-MMT) Working Group. (21495161)
2011
5
A primary hepatic malignant mesenchymal tumor with myofibrogenic differentiation in a B6C3F1 mouse. (19332665)
2009
6
Malignant Mesenchymal Tumor of the Breast: Primary Chondrosarcoma. (20847886)
2009
7
Brachial plexus neuroma mimicking local recurrence of malignant mesenchymal tumor after forequarter amputation. (19292195)
2008
8
Soft tissue sarcoma or malignant mesenchymal tumors in the first year of life: experience of the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor Committee. (15994146)
2005
9
Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology--SIOP Malignant Mesenchymal Tumor 89. (15728225)
2005
10
Malignant mesenchymal tumor arising from cherubism: a case report. (15170291)
2004
11
Severe and prolonged hypoglycemia triggered by long-acting octreotide in a patient with malignant mesenchymal tumor: case report. (12678421)
2003
12
Post-transfusion acute graft versus host disease in a 17-year-old girl with a malignant mesenchymal tumor--report of a case. (15055161)
2003
13
Cyclooxygenase-2 expression in malignant mesenchymal tumors and related uterine lesions. (11605037)
2001
14
Characterization of a dermal derived malignant mesenchymal tumor arising in ultraviolet irradiated mice. (2774057)
1989
15
Mixed malignant mesenchymal tumor of the cerebellar vermis. (228837)
1979
16
Annulate lamellae in a malignant mesenchymal tumor. (416587)
1978
17
Primary malignant mesenchymal tumors (mesenchymoma) of the liver in childhood. An angiographic-pathologic study of three cases. (4751928)
1973
18
Malignant mesenchymal tumor simulating liposarcoma originating in the mediastinum. (13252355)
1955

Variations for Malignant Mesenchymal Tumor

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Expression for genes affiliated with Malignant Mesenchymal Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Mesenchymal Tumor

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Pathways for genes affiliated with Malignant Mesenchymal Tumor

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 55Reactome, 51PharmGKB
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Pathways related to Malignant Mesenchymal Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events38
ErbB2/ErbB3 signaling events38
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
9.1PTGS2, IGFBP3
29.1PTGS2, IGFBP3
39.1PTGS2, IGFBP3

Compounds for genes affiliated with Malignant Mesenchymal Tumor

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45Novoseek, 51PharmGKB, 61Tocris Bioscience, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Malignant Mesenchymal Tumor according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1exemestane45 51 61 1112.4PTGS2, IGFBP3
2silymarin459.4IGFBP3, PTGS2
3prostaglandin f2alpha459.4IGFBP3, PTGS2
4celecoxib45 61 29 51 24 1114.4PTGS2, IGFBP3
5egcg459.4PTGS2, IGFBP3
6curcumin459.4IGFBP3, PTGS2
7aspirin45 51 29 2412.3IGFBP3, PTGS2
8etoposide45 51 61 1112.3PTGS2, IGFBP3
9ly294002459.3PTGS2, IGFBP3
10pge2459.2IGFBP3, PTGS2
11cisplatin45 51 61 1112.2IGFBP3, PTGS2
12cycloheximide459.1PTGS2, IGFBP3
13estrogen459.1IGFBP3, PTGS2
14dexamethasone45 51 29 1112.0PTGS2, IGFBP3
15vegf458.8IGFBP3, PTGS2

GO Terms for genes affiliated with Malignant Mesenchymal Tumor

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16Gene Ontology
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Biological processes related to Malignant Mesenchymal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell proliferationGO:0082859.1PTGS2, IGFBP3
2positive regulation of apoptotic processGO:0430658.8PTGS2, IGFBP3

Products for genes affiliated with Malignant Mesenchymal Tumor

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Sources for Malignant Mesenchymal Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet