MCID: MLG097
MIFTS: 31

Malignant Mesenchymal Tumor malady

Rare diseases, Cancer diseases categories

Summaries for Malignant Mesenchymal Tumor

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MalaCards based summary: Malignant Mesenchymal Tumor, also known as malignant mesenchymoma, is related to rhabdomyosarcoma and sarcoma. An important gene associated with Malignant Mesenchymal Tumor is IGFBP3 (insulin-like growth factor binding protein 3), and among its related pathways are Translation Insulin regulation of translation and Integrated Pancreatic Cancer Pathway. The drugs ifosfamide and mitoxantrone and the compounds exemestane and silymarin have been mentioned in the context of this disorder. Affiliated tissues include liver, breast and prostate, and related mouse phenotypes are muscle and adipose tissue.

Aliases & Classifications for Malignant Mesenchymal Tumor

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Malignant Mesenchymal Tumor, Aliases & Descriptions:

Name: Malignant Mesenchymal Tumor 41 60
Malignant Mesenchymoma 41
 
Sarcoma 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Malignant Mesenchymal Tumor

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Graphical network of the top 20 diseases related to Malignant Mesenchymal Tumor:



Diseases related to malignant mesenchymal tumor

Symptoms for Malignant Mesenchymal Tumor

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Drugs & Therapeutics for Malignant Mesenchymal Tumor

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Drug clinical trials:

Search ClinicalTrials for Malignant Mesenchymal Tumor

Search NIH Clinical Center for Malignant Mesenchymal Tumor

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Malignant Mesenchymal Tumor

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Anatomical Context for Malignant Mesenchymal Tumor

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MalaCards organs/tissues related to Malignant Mesenchymal Tumor:

31
Liver, Breast, Prostate

Animal Models for Malignant Mesenchymal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Malignant Mesenchymal Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.1PTGS2, IGFBP3
2MP:00053759.0PTGS2, IGFBP3
3MP:00053708.8PTGS2, IGFBP3

Publications for Malignant Mesenchymal Tumor

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Articles related to Malignant Mesenchymal Tumor:

(show all 19)
idTitleAuthorsYear
1
The treatment of paravertebral malignant mesenchymal tumor pain with cryoablation. (25037025)
2014
2
Local therapy is critical in localised pelvic rhabdomyosarcoma: experience of the International Society of Pediatric Oncology Malignant Mesenchymal Tumor (SIOP-MMT) committee. (22154650)
2012
3
Comparison of outcomes based on treatment algorithms for rhabdomyosarcoma of the bladder/prostate: combined results from the Children's Oncology Group, German Cooperative Soft Tissue Sarcoma Study, Italian Cooperative Group, and International Society of Pediatric Oncology Malignant Mesenchymal Tumors Committee. (20473932)
2011
4
Malignant mesenchymal tumor with leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, and osteosarcoma differentiation: case report and literature review. (21496258)
2011
5
Sparing strategy does not compromise prognosis in pediatric localized synovial sarcoma: experience of the International Society of Pediatric Oncology, Malignant Mesenchymal Tumors (SIOP-MMT) Working Group. (21495161)
2011
6
A primary hepatic malignant mesenchymal tumor with myofibrogenic differentiation in a B6C3F1 mouse. (19332665)
2009
7
Malignant Mesenchymal Tumor of the Breast: Primary Chondrosarcoma. (20847886)
2009
8
Brachial plexus neuroma mimicking local recurrence of malignant mesenchymal tumor after forequarter amputation. (19292195)
2008
9
Soft tissue sarcoma or malignant mesenchymal tumors in the first year of life: experience of the International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor Committee. (15994146)
2005
10
Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology--SIOP Malignant Mesenchymal Tumor 89. (15728225)
2005
11
Malignant mesenchymal tumor arising from cherubism: a case report. (15170291)
2004
12
Severe and prolonged hypoglycemia triggered by long-acting octreotide in a patient with malignant mesenchymal tumor: case report. (12678421)
2003
13
Post-transfusion acute graft versus host disease in a 17-year-old girl with a malignant mesenchymal tumor--report of a case. (15055161)
2003
14
Cyclooxygenase-2 expression in malignant mesenchymal tumors and related uterine lesions. (11605037)
2001
15
Characterization of a dermal derived malignant mesenchymal tumor arising in ultraviolet irradiated mice. (2774057)
1989
16
Mixed malignant mesenchymal tumor of the cerebellar vermis. (228837)
1979
17
Annulate lamellae in a malignant mesenchymal tumor. (416587)
1978
18
Primary malignant mesenchymal tumors (mesenchymoma) of the liver in childhood. An angiographic-pathologic study of three cases. (4751928)
1973
19
Malignant mesenchymal tumor simulating liposarcoma originating in the mediastinum. (13252355)
1955

Variations for Malignant Mesenchymal Tumor

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Expression for genes affiliated with Malignant Mesenchymal Tumor

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Search GEO for disease gene expression data for Malignant Mesenchymal Tumor.

Pathways for genes affiliated with Malignant Mesenchymal Tumor

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Pathways related to Malignant Mesenchymal Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Transcription Receptor mediated HIF regulation58
Development CNTF receptor signaling58
Class IB PI3K non-lipid kinase events36
ErbB2/ErbB3 signaling events36
Development Growth hormone signaling via PI3K AKT and MAPK cascades58
Translation Regulation activity of EIF258
Regulation of lipid metabolism Insulin signaling generic cascades58
Transcription PPAR Pathway58
Cell adhesion PLAU signaling58
Translation Regulation activity of EIF4F58
9.1PTGS2, IGFBP3
29.1PTGS2, IGFBP3
39.1PTGS2, IGFBP3

Compounds for genes affiliated with Malignant Mesenchymal Tumor

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Compounds related to Malignant Mesenchymal Tumor according to GeneCards Suite gene sharing:

(show all 15)
idCompoundScoreTop Affiliating Genes
1exemestane43 49 59 1212.4PTGS2, IGFBP3
2silymarin439.4PTGS2, IGFBP3
3prostaglandin f2alpha439.4PTGS2, IGFBP3
4celecoxib43 59 28 49 24 1214.4IGFBP3, PTGS2
5egcg439.4PTGS2, IGFBP3
6curcumin439.4PTGS2, IGFBP3
7aspirin43 49 28 2412.3PTGS2, IGFBP3
8etoposide43 49 59 1212.3IGFBP3, PTGS2
9ly294002439.3PTGS2, IGFBP3
10pge2439.2PTGS2, IGFBP3
11cisplatin43 49 59 1212.2PTGS2, IGFBP3
12cycloheximide439.1IGFBP3, PTGS2
13estrogen439.1PTGS2, IGFBP3
14dexamethasone43 49 28 1212.0PTGS2, IGFBP3
15vegf438.8PTGS2, IGFBP3

GO Terms for genes affiliated with Malignant Mesenchymal Tumor

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Biological processes related to Malignant Mesenchymal Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell proliferationGO:00082859.1PTGS2, IGFBP3
2positive regulation of apoptotic processGO:00430658.8PTGS2, IGFBP3

Products for genes affiliated with Malignant Mesenchymal Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Malignant Mesenchymal Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet