MCID: MLG074
MIFTS: 40

Malignant Mesenchymoma malady

Cancer diseases category

Summaries for Malignant Mesenchymoma

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34MalaCards
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MalaCards: Malignant Mesenchymoma, also known as malignant mesenchymal tumor, is related to sarcoma and leiomyosarcoma. An important gene associated with Malignant Mesenchymoma is MYOG (myogenin (myogenic factor 4)), and among its related pathways are L1CAM interactions and Immune response Function of MEF2 in T lymphocytes. The compounds bromodeoxyuridine and 12-o-tetradecanoylphorbol 13-acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and kidney, and related mouse phenotype adipose tissue.

Aliases & Classifications for Malignant Mesenchymoma

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Sources:
9Disease Ontology, 11DISEASES, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant mesenchymoma 9 11
malignant mesenchymal tumor 63
mesenchymoma, malignant 9


External Ids:

Disease Ontology9 DOID:5758
MeSH36 C535700
SNOMED-CT59 89623007
NCIt41 C4268

Related Diseases for Malignant Mesenchymoma

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Malignant Mesenchymoma:



Diseases related to malignant mesenchymoma

Symptoms for Malignant Mesenchymoma

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Drugs & Therapeutics for Malignant Mesenchymoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Malignant Mesenchymoma

Drug clinical trials:

Search ClinicalTrials for Malignant Mesenchymoma

Search NIH Clinical Center for Malignant Mesenchymoma

Search CenterWatch for Malignant Mesenchymoma

Genetic Tests for Malignant Mesenchymoma

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Anatomical Context for Malignant Mesenchymoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Malignant Mesenchymoma:

34
Bone, Heart, Kidney, Lung, Liver, Uterus, Prostate, Small intestine, Brain, Thyroid, Breast, Cervix

Animal Models for Malignant Mesenchymoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Malignant Mesenchymoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.1MYOG, MYOD1

Publications for Malignant Mesenchymoma

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53PubMed
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Articles related to Malignant Mesenchymoma:

(show top 50)    (show all 117)
idTitleAuthorsYear
1
Malignant mesenchymoma of the heart base in a dog with infiltration of the pericardium and metastasis to the lung. (22516086)
2012
2
Malignant mesenchymoma in the nasal cavity of a bull. (21306728)
2011
3
Malignant mesenchymoma of the thyroid: case report and literature review. (20572598)
2010
4
Malignant mesenchymoma surrounding the esophageal hiatus. (20103193)
2010
5
An intra-abdominal malignant mesenchymoma associated with nonabsorbable sutures in a ferret (Mustela putorius furo). (20224105)
2010
6
Uterine malignant mesenchymoma, arising in a leiomyoma, with pulmonary metastases. (17257144)
2007
7
Left atrial malignant mesenchymoma--emergency resection and mitral replacement. (17664193)
2007
8
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone. (15792374)
2004
9
Primary osteochondrorhabdomyosarcoma (malignant mesenchymoma) of the fibula: a rare tumour in an unusual site -- case report and review of the literature. (15601312)
2004
10
Malignant mesenchymoma of the orbit: case report and review of the literature. (12578773)
2003
11
Malignant mesenchymoma of the pleura. (17670075)
2003
12
Malignant mesenchymoma of the uterus, arising in a leiomyoma. (11903599)
2002
13
Primary malignant mesenchymoma of the heart. (11788281)
2002
14
Giant malignant mesenchymoma of the spermatic cord with bidirectional differentiation. (11441285)
2001
15
Retroperitoneal malignant mesenchymoma: imaging findings in five cases. (9933683)
1999
16
Primary left atrial malignant mesenchymoma: a case report. (9607271)
1998
17
Malignant mesenchymoma of the spermatic cord with a brief review of the literature. (9179703)
1997
18
Maxillary malignant mesenchymoma and massive fibrous dysplasia. (9006514)
1997
19
Clinical image. Malignant mesenchymoma of the buttock. (8933808)
1996
20
Malignant mesenchymoma of the thigh. (7644947)
1995
21
Primary malignant mesenchymoma of bone: case report, literature review, and distinction of this entity from mesenchymal and dedifferentiated chondrosarcoma. (7644944)
1995
22
Malignant mesenchymoma of the spermatic cord. (8088727)
1994
23
Malignant mesenchymoma of the brain. A case report. (1603236)
1992
24
Case report: malignant mesenchymoma of the mediastinum. (1454238)
1992
25
Infantile malignant mesenchymoma: limb salvage therapy. (1813594)
1991
26
Malignant mesenchymoma: a very rare tumor of the peritoneum. Case report with a review of the literature. (2034003)
1991
27
Malignant mesenchymoma associated with a congenital lung cyst in a child: case report and review of the literature. (2235763)
1990
28
Primary malignant mesenchymoma of bone. (2189375)
1990
29
Malignant mesenchymoma of the larynx. (2370480)
1990
30
A case report of malignant mesenchymoma with discussion of musculoskeletal tumor staging: the Enneking system. (3174499)
1988
31
Hepatic malignant mesenchymoma in a dog. (3710891)
1986
32
Malignant mesenchymoma of the spermatic cord. (6583431)
1984
33
Malignant mesenchymoma of the small intestine. (6546496)
1984
34
Case report of a primary cystic sarcoma of the kidney, demonstrating fibrohistiocytic, osteoid, and cartilaginous components (malignant mesenchymoma). (7127261)
1982
35
Malignant mesenchymoma of the heart. (7136698)
1982
36
Malignant mesenchymoma obstructing the right ventricular outflow tract. (7457335)
1981
37
Malignant mesenchymoma developing 6 years after radical hysterectomy and postoperative radiotherapy for cervical carcinoma. (7308872)
1981
38
Roentgenographic findings in malignant mesenchymoma of bone. (7462884)
1980
39
Malignant mesenchymoma of the retroperitoneum: a case report. (45668)
1979
40
Case report. Paratesticular malignant mesenchymoma. (750460)
1978
41
Ganglioneuroblastoma associated with malignant mesenchymoma. (1182658)
1975
42
Malignant mesenchymoma. Case report with electron microscopic study. (1182662)
1975
43
Malignant mesenchymoma of the lung. (4686511)
1973
44
Malignant mesenchymoma of mediastinum: a case report. (4781270)
1973
45
Malignant mesenchymoma of the mediastinum. Report of a case. (4731433)
1973
46
Congenital malignant mesenchymoma of the face. Case report. (5060326)
1972
47
Primary congenital malignant mesenchymoma of the eyelid. (5119569)
1971
48
MALIGNANT MESENCHYMOMA OF THE HEART. (14290326)
1965
49
Malignant mesenchymoma (haemangioblastomyxomatous variety) in a five-year-old boy. (13671401)
1959
50
Malignant mesenchymoma of the kidney: case report. (13417295)
1957

Variations for Malignant Mesenchymoma

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Expression for genes affiliated with Malignant Mesenchymoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Mesenchymoma

Search GEO for disease gene expression data for Malignant Mesenchymoma.

Pathways for genes affiliated with Malignant Mesenchymoma

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Sources:
51PathCards, 56Reactome, 61Thomson Reuters, 39NCBI BioSystems Database
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Pathways related to Malignant Mesenchymoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.1MYOG, MYOD1
2
Show member pathways
Development Role of HDAC and calcium calmodulin dependent kinase CaMK in control of skeletal myogenesis61
9.1MYOG, MYOD1
39.1MYOG, MYOD1
4
Show member pathways
9.1MYOG, MYOD1

Compounds for genes affiliated with Malignant Mesenchymoma

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Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 25HMDB, 12DrugBank, 62Tocris Bioscience
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Compounds related to Malignant Mesenchymoma according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
1bromodeoxyuridine469.4MYOG, MYOD1
212-o-tetradecanoylphorbol 13-acetate469.4MYOG, MYOD1
3butyrate469.4MYOG, MYOD1
4acetylcholine46 52 30 25 1213.4MYOG, MYOD1
5paraffin469.4MYOD1, MYOG
6fatty acid469.4MYOG, MYOD1
7creatinine469.4MYOG, MYOD1
8testosterone46 62 25 1212.3MYOG, MYOD1
9steroid469.3MYOD1, MYOG
10oligonucleotide469.3MYOG, MYOD1
11vegf469.2MYOG, MYOD1
12oxygen46 2510.2MYOG, MYOD1
13estrogen469.1MYOD1, MYOG
14glucose469.1MYOG, MYOD1
15retinoic acid46 2510.0MYOG, MYOD1
16cysteine468.8MYOG, MYOD1

GO Terms for genes affiliated with Malignant Mesenchymoma

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17Gene Ontology
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Cellular components related to Malignant Mesenchymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription factor complexGO:0056679.1MYOG, MYOD1

Biological processes related to Malignant Mesenchymoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1muscle cell fate commitmentGO:0426939.3MYOG, MYOD1
2skeletal muscle fiber developmentGO:0487419.2MYOG, MYOD1
3cellular response to estradiol stimulusGO:0713929.2MYOG, MYOD1
4positive regulation of muscle cell differentiationGO:0511499.1MYOD1, MYOG
5positive regulation of transcription from RNA polymerase II promoterGO:0459449.1MYOG, MYOD1
6muscle cell differentiationGO:0426929.0MYOG, MYOD1
7skeletal muscle tissue developmentGO:0075198.8MYOG, MYOD1

Molecular functions related to Malignant Mesenchymoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatin DNA bindingGO:0314909.1MYOG, MYOD1
2protein heterodimerization activityGO:0469829.1MYOG, MYOD1
3E-box bindingGO:0708889.0MYOG, MYOD1
4core promoter bindingGO:0010478.8MYOG, MYOD1

Products for genes affiliated with Malignant Mesenchymoma

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Sources for Malignant Mesenchymoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet