MCID: MLG074
MIFTS: 39

Malignant Mesenchymoma malady

Categories: Rare diseases, Cancer diseases, Nephrological diseases

Aliases & Classifications for Malignant Mesenchymoma

Aliases & Descriptions for Malignant Mesenchymoma:

Name: Malignant Mesenchymoma 12 50 14
Malignant Mesenchymal Tumor 50 42 69
Rat Malignant Renal Mesenchymal Tumor 69
Mesenchymoma, Malignant 12
Sarcoma 69

Classifications:



External Ids:

Disease Ontology 12 DOID:5758
MeSH 42 C535700
NCIt 47 C4268
SNOMED-CT 64 89623007
UMLS 69 C0334492

Summaries for Malignant Mesenchymoma

MalaCards based summary : Malignant Mesenchymoma, also known as malignant mesenchymal tumor, is related to childhood malignant mesenchymoma and adult malignant mesenchymoma. An important gene associated with Malignant Mesenchymoma is MB (Myoglobin), and among its related pathways/superpathways are Thyroid hormone signaling pathway and DNA Damage Response (only ATM dependent). The drugs Doxorubicin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and kidney, and related phenotypes are Decreased viability in esophageal squamous lineage and Increased HPV16-GFP infection

Related Diseases for Malignant Mesenchymoma

Diseases in the Mesenchymoma family:

Benign Mesenchymoma Malignant Mesenchymoma
Adult Malignant Mesenchymoma

Diseases related to Malignant Mesenchymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
id Related Disease Score Top Affiliating Genes
1 childhood malignant mesenchymoma 12.0
2 adult malignant mesenchymoma 12.0
3 gallbladder sarcoma 10.9
4 mesenchymoma 10.7
5 glaucoma iridogoniodysgenesia 10.2 DES MB
6 reticulohistiocytic granuloma 10.1 DES MB
7 extracutaneous mastocytoma 10.1 DES MB
8 rectal neoplasm 10.1 DES MB
9 urethral cancer 10.1 DES PIK3CA
10 t-cell childhood lymphoblastic lymphoma 10.1 DES MB
11 brain stem infarction 10.1 MB MYOD1
12 van regemorter pierquin vamos syndrome 10.1 DES MB
13 ectopic pregnancy 10.1 DES MYOD1
14 testis sarcoma 10.1 DES MYOD1
15 hyperpituitarism 10.1 DES MB
16 glomerulonephritis 10.1 MB MYOD1
17 cardiac tamponade 10.1 DES MYOD1
18 extraosseous osteosarcoma 10.1 DES MYOD1
19 sarcoma 10.1
20 lung benign neoplasm 10.0 DES MYOD1
21 acantholytic squamous cell skin carcinoma 10.0 MB TP53
22 functionless pituitary adenoma 10.0 MB TP53
23 liposarcoma 10.0
24 choriocarcinoma of ovary 10.0 MB TP53
25 juvenile xanthogranuloma 10.0 DES MYOD1
26 rhabdomyosarcoma, embryonal, 2 10.0 MB TP53
27 diabetes persistent mullerian ducts 10.0 DES MYOD1
28 sclerosing breast papilloma 10.0 PIK3CA TP53
29 mediastinum rhabdomyosarcoma 10.0 MB MYOD1
30 adult syndrome 10.0 PIK3CA TP53
31 intraorbital meningioma 10.0 MB TP53
32 uterine disease 10.0 PIK3CA TP53
33 arthus reaction 10.0 MB TP53
34 exudative glomerulonephritis 10.0 DES TP53
35 house allergic alveolitis 10.0 DES TP53
36 glomangioma 10.0 DES TP53
37 uterine corpus endometrial stromal sarcoma 10.0 PIK3CA TP53
38 spastic paraplegia 1 10.0 PIK3CA TP53
39 reactive arthritis 10.0 PIK3CA TP53
40 megalencephaly-capillary malformation-polymicrogyria syndrome, somatic 10.0 PIK3CA TP53
41 mediastinum synovial sarcoma 10.0 PIK3CA TP53
42 retroperitoneal neuroblastoma 10.0 PIK3CA TP53
43 myxedema 10.0 PIK3CA TP53
44 mixed type rhabdomyosarcoma 9.9 DES MB MYOD1
45 progesterone-receptor negative breast cancer 9.9 PIK3CA TP53
46 intrahepatic bile duct cystadenoma 9.9 DES MB MYOD1
47 transitional cell carcinoma 9.9 DES MB MYOD1
48 ovarian cystadenoma 9.9 DES MB MYOD1
49 bile duct rhabdomyosarcoma 9.9 DES MB MYOD1
50 leiomyoma 9.9

Graphical network of the top 20 diseases related to Malignant Mesenchymoma:



Diseases related to Malignant Mesenchymoma

Symptoms & Phenotypes for Malignant Mesenchymoma

GenomeRNAi Phenotypes related to Malignant Mesenchymoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.35 MB MYOD1 PIK3CA TP53 DES
2 Increased HPV16-GFP infection GR00350-A 8.8 DES MYOD1 PIK3CA

MGI Mouse Phenotypes related to Malignant Mesenchymoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 DES MB MYOD1 PIK3CA TP53
2 muscle MP:0005369 9.02 TP53 DES MB MYOD1 PIK3CA

Drugs & Therapeutics for Malignant Mesenchymoma

Drugs for Malignant Mesenchymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
3
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
4
Topotecan Approved, Investigational Phase 3 119413-54-6, 123948-87-8 60700
5
Vinorelbine Approved, Investigational Phase 3 71486-22-1 60780 44424639
6
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
8
Morphine Approved, Investigational Phase 3 57-27-2 5288826
9
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
10
Mechlorethamine Approved Phase 3,Phase 1 51-75-2 4033
11
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
12
Irinotecan Approved, Investigational Phase 3,Phase 2 97682-44-5, 100286-90-6 60838
13
Lenograstim Approved Phase 3,Phase 2 135968-09-1
14
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
15
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
16
Mesna Approved Phase 3 3375-50-6 598
17
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
18
Camptothecin Experimental Phase 3,Phase 2 7689-03-4
19 Alkylating Agents Phase 3,Phase 2,Phase 1
20 topoisomerase I inhibitors Phase 3,Phase 2
21 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
22 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
23 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
24 Etoposide phosphate Phase 3,Phase 2
25 Anti-Infective Agents Phase 3,Phase 2
26 Immunosuppressive Agents Phase 3,Phase 2
27 Isophosphamide mustard Phase 3,Phase 2,Phase 1
28 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
29 Antimitotic Agents Phase 3,Phase 2
30 Antirheumatic Agents Phase 3,Phase 2
31 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
32 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
33 Adjuvants, Immunologic Phase 3,Phase 1
34
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
35
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
36
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
37
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
38
Gemcitabine Approved Phase 2 95058-81-4 60750
39 Imatinib Mesylate Phase 2,Phase 1 123596
40 Angiogenesis Inhibitors Phase 2,Phase 1
41 Angiogenesis Modulating Agents Phase 2,Phase 1
42 Protein Kinase Inhibitors Phase 2,Phase 1
43 Antimetabolites Phase 2
44 Antimetabolites, Antineoplastic Phase 2
45 Antiviral Agents Phase 2
46 razoxane Phase 2
47 Protective Agents Phase 2
48 Immunoglobulins Phase 1
49 Antibodies, Monoclonal Phase 1
50 Antibodies Phase 1

Interventional clinical trials:

(show all 32)
id Name Status NCT ID Phase
1 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Unknown status NCT00346164 Phase 3
2 Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma Unknown status NCT00379457 Phase 3
3 Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma Completed NCT00003958 Phase 3
4 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00002995 Phase 3
5 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3
6 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3
7 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3
8 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma Recruiting NCT01344018 Phase 3
9 Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Active, not recruiting NCT00354835 Phase 3
10 High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma Active, not recruiting NCT00354744 Phase 3
11 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
12 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3
13 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2
14 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2
15 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
16 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma Completed NCT00003955 Phase 2
17 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2
18 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2
19 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2
20 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2
21 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2
22 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2
23 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2
24 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2
25 Irinotecan and Carboplatin as Upfront Window Therapy in Treating Patients With Newly Diagnosed Intermediate-Risk or High-Risk Rhabdomyosarcoma Active, not recruiting NCT00077285 Phase 2
26 Intensity-Modulated Radiation Therapy in Treating Patients Undergoing Surgery for Stage IB, Stage II, or Stage III Soft Tissue Sarcoma Terminated NCT00740597 Phase 2
27 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1
28 Liposomal Doxorubicin Plus Ifosfamide in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00030784 Phase 1
29 NHS-IL12 for Solid Tumors Recruiting NCT01417546 Phase 1
30 Tissue Sample Collection From Patients With Soft Tissue Sarcoma of the Arms, Hands, Legs, or Feet Treated on Clinial Trial CRUK-VORTEX Unknown status NCT00900211
31 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
32 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984

Search NIH Clinical Center for Malignant Mesenchymoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: malignant mesenchymal tumor

Genetic Tests for Malignant Mesenchymoma

Anatomical Context for Malignant Mesenchymoma

MalaCards organs/tissues related to Malignant Mesenchymoma:

39
Bone, Heart, Kidney, Lung, Liver, Breast, Prostate

Publications for Malignant Mesenchymoma

Articles related to Malignant Mesenchymoma:

(show top 50) (show all 120)
id Title Authors Year
1
Critical reappraisal of primary osseous composite sarcoma (malignant mesenchymoma) - analysis of four cases and literature review. ( 27102568 )
2016
2
Malignant mesenchymoma with widespread metastasis including bone marrow involvement in a dog. ( 25132008 )
2014
3
Diagnosis and treatment considerations in a case of malignant mesenchymoma in an African fur seal (Arctocephalus pusillus). ( 23805568 )
2013
4
Combined cutaneous sarcoma: pleomorphic liposarcoma and conventional osteosarcoma-the so-called malignant mesenchymoma. ( 23082265 )
2012
5
Malignant mesenchymoma of the heart base in a dog with infiltration of the pericardium and metastasis to the lung. ( 22516086 )
2012
6
Metastatic leiomyosarcoma of the uterus with heterologous differentiation to malignant mesenchymoma. ( 22833086 )
2012
7
Malignant mesenchymoma in the nasal cavity of a bull. ( 21306728 )
2011
8
Malignant mesenchymoma of the thyroid: case report and literature review. ( 20572598 )
2010
9
An intra-abdominal malignant mesenchymoma associated with nonabsorbable sutures in a ferret (Mustela putorius furo). ( 20224105 )
2010
10
Malignant mesenchymoma surrounding the esophageal hiatus. ( 20103193 )
2010
11
Surgical case of giant malignant mesenchymoma in the posterior mediastinum that recurred in the bilateral mediastinum. ( 18781043 )
2008
12
Uterine malignant mesenchymoma, arising in a leiomyoma, with pulmonary metastases. ( 17257144 )
2007
13
Left atrial malignant mesenchymoma--emergency resection and mitral replacement. ( 17664193 )
2007
14
Intermandibular malignant mesenchymoma in a crossbreed dog. ( 16961475 )
2006
15
Malignant mesenchymoma arising from a uterine leiomyoma in the menopause. ( 15581987 )
2004
16
Osteosarcoma with rhabdomyosarcomatous component or so-called malignant mesenchymoma of bone. ( 15792374 )
2004
17
Primary osteochondrorhabdomyosarcoma (malignant mesenchymoma) of the fibula: a rare tumour in an unusual site -- case report and review of the literature. ( 15601312 )
2004
18
Prognostic factors in the so-called malignant mesenchymoma: a clinicopathological and immunohistochemical analysis. ( 12792727 )
2003
19
Malignant mesenchymoma of the pleura. ( 17670075 )
2003
20
Malignant mesenchymoma of the orbit: case report and review of the literature. ( 12578773 )
2003
21
Malignant mesenchymoma of the uterus, arising in a leiomyoma. ( 11903599 )
2002
22
Retroperitoneal malignant mesenchymoma: a case of mesenchymal mixed tumor with osteosarcoma, leiomyosarcoma, liposarcoma and fibrosarcoma. ( 12514345 )
2002
23
Radical resection of a malignant mesenchymoma with hypogastric artery transposition. ( 12210036 )
2002
24
Primary malignant mesenchymoma of the heart. ( 11788281 )
2002
25
Giant malignant mesenchymoma of the spermatic cord with bidirectional differentiation. ( 11441285 )
2001
26
Malignant mesenchymoma of the lower leg. ( 11684725 )
2001
27
Ring chromosomes in a malignant mesenchymoma. ( 10087943 )
1999
28
Retroperitoneal malignant mesenchymoma: imaging findings in five cases. ( 9933683 )
1999
29
Malignant mesenchymoma arising in an incisional scar of the abdominal wall. ( 9800981 )
1998
30
Primary left atrial malignant mesenchymoma: a case report. ( 9607271 )
1998
31
Malignant mesenchymoma associated with an unusual vasoinvasive metastasis in a dog. ( 9657162 )
1998
32
Primary osteorhabdomyosarcoma (malignant mesenchymoma) of bone: a case report and review of the literature. ( 9346186 )
1997
33
Maxillary malignant mesenchymoma and massive fibrous dysplasia. ( 9006514 )
1997
34
Radiation-induced malignant mesenchymoma of the chest wall following treatment for breast cancer. ( 9166083 )
1997
35
Malignant mesenchymoma of the spermatic cord with a brief review of the literature. ( 9179703 )
1997
36
Dedifferentiated cystic nephroma with malignant mesenchymoma as the dedifferentiated component. ( 9025898 )
1996
37
Malignant mesenchymoma arising from the prostate in Gardner's syndrome. ( 8776827 )
1996
38
Malignant mesenchymoma of the pleura. ( 8638184 )
1996
39
Clinical image. Malignant mesenchymoma of the buttock. ( 8933808 )
1996
40
Malignant mesenchymoma. ( 8630953 )
1996
41
Primary malignant mesenchymoma of bone: case report, literature review, and distinction of this entity from mesenchymal and dedifferentiated chondrosarcoma. ( 7644944 )
1995
42
Malignant mesenchymoma of the thigh. ( 7644947 )
1995
43
Malignant mesenchymoma as a primary urinary bladder tumour. ( 7767934 )
1995
44
Panuveal malignant mesenchymoma. ( 7668945 )
1995
45
Malignant mesenchymoma of the prostate: immunohistochemical and ultrastructural observations. ( 7941044 )
1994
46
Malignant mesenchymoma of the spermatic cord. ( 8088727 )
1994
47
Retroperitoneal malignant mesenchymoma: a case report. ( 7614386 )
1994
48
CT findings of retroperitoneal malignant mesenchymoma. ( 8161915 )
1994
49
A case of retroperitoneal malignant mesenchymoma. ( 7834083 )
1994
50
Malignant mesenchymoma of the kidney. ( 8365718 )
1993

Variations for Malignant Mesenchymoma

Expression for Malignant Mesenchymoma

Search GEO for disease gene expression data for Malignant Mesenchymoma.

Pathways for Malignant Mesenchymoma

GO Terms for Malignant Mesenchymoma

Biological processes related to Malignant Mesenchymoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-mediated signaling GO:0048015 8.62 PIK3CA TP53

Sources for Malignant Mesenchymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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