MCID: MLG075
MIFTS: 67

Malignant Mesothelioma malady

Rare diseases, Cancer diseases, Respiratory diseases categories
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Summaries for Malignant Mesothelioma

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8Disease Ontology, 47OMIM, 33MalaCards
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Disease Ontology:8 A cell type cancer that has material basis in meothelial tissue.

MalaCards: Malignant Mesothelioma, also known as mesothelioma, is related to malignant peritoneal mesothelioma and lung cancer. An important gene associated with Malignant Mesothelioma is MMS (Malignant mesothelioma, susceptibility to), and among its related pathways are N-cadherin signaling events and CDO in myogenesis. The compounds indium and polyethylene glycol have been mentioned in the context of this disorder. Affiliated tissues include lung, testis and breast, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Description from OMIM:47 156240

Aliases & Classifications for Malignant Mesothelioma

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8Disease Ontology, 49Orphanet, 62UMLS, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 9diseasecard, 22GTR, 40NCIt, 58SNOMED-CT, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

49
mesothelioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

malignant mesothelioma 8 43 47 10 45 62
mesothelioma 8 49 62
malignant mesothelioma, susceptibility to 9 22
advanced malignant mesothelioma 8 62
mesothelioma, malignant 8 43
asbestos-related malignant mesothelioma 8
diffuse malignant mesothelioma 8
malignant tumor of mesothelium 8
mesothelioma diffuse malignant 45


External Ids:

Disease Ontology8 DOID:1790
NCIt40 C7865
OMIM47 156240
MESH via Orphanet36 D008654
SNOMED-CT58 62064005
ICD10 via Orphanet26 C45
SNOMED-CT via Orphanet59 62064005
UMLS via Orphanet63 C0025500
ICD1025 C45, C45.9

Related Diseases for Malignant Mesothelioma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Mesothelioma family:

Benign Intermediate Mesothelioma Benign Mesothelioma

Diseases related to Malignant Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1malignant peritoneal mesothelioma30.7CALB2
2lung cancer30.6MUC1, MET, NKX2-1
3malignant pleural mesothelioma30.6MSLN, CALB2
4adenomatoid tumor30.6WT1, CALB2
5wilms tumor30.5CALB2, NKX2-1, PDPN, WT1
6adenocarcinoma30.5CDH2, PDPN, NKX2-1, CALB2, MET, MSLN
7synovial sarcoma30.5CALB2, MET, MUC1
8papillary adenocarcinoma30.4MUC1, NKX2-1
9sarcoma30.4WT1, CALB2, MET, MUC1, SOD2
10benign mesothelioma30.3WT1, PDPN, NKX2-1, CALB2, MSLN, THBD
11cystadenocarcinoma30.2CEACAM3, MUC1
12ovarian cancer30.2SPP1, MUC1, CEACAM3, MSLN, MET, CALB2
13interstitial lung disease30.1NKX2-1, SFTPB
14pulmonary alveolar proteinosis30.1CEACAM3, MUC1, SFTPB
15angiosarcoma30.1MUC1, CALB2, PDPN
16non-small cell lung carcinoma30.1SFTPB, MET, NKX2-1
17malignant peripheral nerve sheath tumor30.1MUC1, MET
18melanoma30.0SPP1, SOD2, CEACAM3, MET, CALB2, NKX2-1
19colorectal cancer29.9MUC1, CEACAM3, MET, PDPN, CTNNA1
20mucinous cystadenocarcinoma29.9CEACAM3, MUC1
21lung adenocarcinoma29.9SFTPB, THBD, SPP1, SOD2, MUC1, CTNNA1
22hemangioma29.8SFTPB, NKX2-1, PDPN
23papillary carcinoma29.8SOD2, MUC1, CEACAM3, MET, CALB2, NKX2-1
24papillary thyroid carcinoma29.8MET, SPP1
25endometrial carcinoma29.8CALB2, NKX2-1, CDH2
26thymoma29.8CTNNA1, NKX2-1, CALB2, CEACAM3
27chondrosarcoma29.7MUC1, CEACAM3, MET, CTNNA1
28hepatocellular carcinoma29.7SPP1, SOD2, CEACAM3, MET, NKX2-1, CDH2
29breast cancer29.6SPP1, SOD2, MUC1, CEACAM3, MSLN, MET
30glioblastoma multiforme29.6SOD2, MET, PDPN, CDH2, CTNNA1
31astrocytoma29.5CTNNA1, CDH2, MET, SOD2, SPP1
32stomach cancer29.4SPP1, SOD2, CEACAM3, MET, PDPN, CDH2
33peritoneal mesothelioma11.0
34peritonitis10.6
35benign multicystic peritoneal mesothelioma10.6
36sarcomatoid mesothelioma10.6
37peritoneal cystic mesothelioma10.4
38leukemia10.4
39benign fibrous mesothelioma10.4
40malignant epithelial mesothelioma10.4
41endotheliitis10.4
42hydrocele10.3
43benign pleural mesothelioma10.3
44neurofibromatosis10.3
45ovarian malignant mesothelioma10.3
46asbestosis10.3
47pleurisy10.3
48benign peritoneal mesothelioma10.2
49cardiac tamponade10.2
50thrombocytosis10.2

Graphical network of the top 20 diseases related to Malignant Mesothelioma:



Diseases related to malignant mesothelioma

Symptoms for Malignant Mesothelioma

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47OMIM
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Clinical features from OMIM:

156240

Drugs & Therapeutics for Malignant Mesothelioma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Malignant Mesothelioma

Search NIH Clinical Center for Malignant Mesothelioma

Genetic Tests for Malignant Mesothelioma

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22GTR
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Genetic tests related to Malignant Mesothelioma:

id Genetic test Affiliating Genes
1 Mesothelioma, Malignant22

Anatomical Context for Malignant Mesothelioma

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33MalaCards
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MalaCards organs/tissues related to Malignant Mesothelioma:

33
Lung, Testis, Breast, Endothelial, T cells, Skin, Bone, Pancreas, Lymph node, Brain, Testes, Colon, Liver, Thyroid, Placenta, Kidney, Monocytes, B cells, Appendix

Animal Models for Malignant Mesothelioma or affiliated genes

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37MGI
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Publications for Malignant Mesothelioma

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Sources:
52PubMed
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Articles related to Malignant Mesothelioma:

(show top 50)    (show all 694)
idTitleAuthorsYear
1
The assessment of the malignant mesothelioma cases and environmental asbestos exposure in Sivas province, Turkey. (23553125)
2014
2
Diffuse intrapulmonary malignant mesothelioma masquerading as interstitial lung disease: a distinctive variant of mesothelioma. (23797722)
2013
3
Legal claims for malignant mesothelioma: dealing with all cases. (23415607)
2013
4
Treatment and survival analyses of malignant mesothelioma in Japan. (22928694)
2013
5
Pleuroscopic punch biopsy using insulated-tip diathermic knife-2 for the diagnosis of desmoplastic malignant mesothelioma. (24162121)
2013
6
18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography fused imaging in malignant mesothelioma patients: looking from outside is not enough. (23206832)
2013
7
Estrogen receptor I^ activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo. (24061575)
2013
8
Malignant mesothelioma: new insights into a rare disease. (23276688)
2013
9
Does CA125 binding to mesothelin impact the detection of malignant mesothelioma? (23357461)
2013
10
Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis. (22208496)
2012
11
The ticking time-bomb of asbestos: its insidious role in the development of malignant mesothelioma. (22459593)
2012
12
Adiponectin pathway attenuates malignant mesothelioma cell growth. (22095628)
2012
13
Plasma versus serum levels of osteopontin and mesothelin in patients with malignant mesothelioma--which is best? (21397972)
2011
14
miR-34a expression, cell cycle arrest and cell death of malignant mesothelioma cells upon treatment with radiation, docetaxel or combination treatment. (22237142)
2011
15
EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene. (21869823)
2011
16
Association of malignant mesothelioma and asbestos related conditions with ovarian cancer: shared biomarkers and a possible etiological link? (21158701)
2011
17
LATS2 is a tumor suppressor gene of malignant mesothelioma. (21245096)
2011
18
Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma. (21281820)
2011
19
Biomarkers in malignant mesothelioma: diagnostic and prognostic role of soluble mesothelin-related peptide. (21928246)
2011
20
Oral presentation of malignant mesothelioma. (20813558)
2011
21
Characterization of side population cells in human malignant mesothelioma cell lines. (20493579)
2010
22
Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. (20573372)
2010
23
Pleural malignant mesothelioma with osteoclast-like giant cells. (20403048)
2010
24
Pemetrexed in the treatment of malignant mesothelioma: results from an expanded access program in Germany. (19818589)
2010
25
Tenascin-X is a novel diagnostic marker of malignant mesothelioma. (19738457)
2009
26
Lymphangiomatoid pattern in diffuse malignant mesothelioma of the pleura: a report of six cases. (19618209)
2009
27
Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group. (19653732)
2009
28
Utility of WT-1, p63, MOC31, mesothelin, and cytokeratin (K903 and CK5/6) immunostains in differentiating adenocarcinoma, squamous cell carcinoma, and malignant mesothelioma in effusions. (18064689)
2008
29
Prolonged survival due to spontaneous regression and surgical excision of malignant mesothelioma. (17184695)
2007
30
Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. (17192790)
2007
31
Malignant mesothelioma: global incidence and relationship with asbestos. (17634686)
2007
32
Malignant mesothelioma following thoracic radiotherapy for lung cancer. (17475364)
2007
33
Staging in malignant mesothelioma. (17126172)
2006
34
Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling. (16007577)
2005
35
Malignant mesothelioma of the spermatic cord: case report and review of the literature. (17629883)
2005
36
Reduced Fhit protein expression in human malignant mesothelioma. (14569398)
2004
37
Inhibition of proliferation, migration, and matrix metalloprotease production in malignant mesothelioma cells by tyrosine kinase inhibitors. (15720796)
2004
38
Assessment of cell cycle state may facilitate the histopathological diagnosis of malignant mesothelioma. (12713628)
2003
39
Quinidine impairs proliferation of neurofibromatosis type 2-deficient human malignant mesothelioma cells. (12673723)
2003
40
Gene expression profiling of malignant mesothelioma. (12912960)
2003
41
Transforming growth factor-beta released by PPD-presenting malignant mesothelioma cells inhibits interferon-gamma synthesis by an anti-PPD CD4+ T-cell clone. (12525871)
2003
42
Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura. (12771921)
2003
43
Expression and prognostic significance of catalase in malignant mesothelioma. (11283936)
2001
44
The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma. (11697834)
2001
45
Localized malignant mesothelioma of the pleura. (11564223)
2001
46
Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma. (11479207)
2001
47
Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma. (10916757)
2000
48
The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma. (9466670)
1998
49
Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma. (9139887)
1997
50
p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. (7923195)
1994

Variations for Malignant Mesothelioma

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Expression for genes affiliated with Malignant Mesothelioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Mesothelioma

Search GEO for disease gene expression data for Malignant Mesothelioma.

Pathways for genes affiliated with Malignant Mesothelioma

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 5Cell Signaling Technology, 53QIAGEN
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Pathways related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CTNNA1, CDH2
2
Show member pathways
9.7CTNNA1, CDH2
39.7CTNNA1, CDH2
49.4SPP1, MET, CDH2
59.4CTNNA1, CDH2, MUC1
69.3CTNNA1, CDH2, MET
7
Show member pathways
8.7SPP1, MUC1, MET, CDH2, CTNNA1

Compounds for genes affiliated with Malignant Mesothelioma

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Sources:
45Novoseek, 3BitterDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 29IUPHAR
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Compounds related to Malignant Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1indium459.9CEACAM3, MUC1
2polyethylene glycol459.6MUC1, THBD, SPP1
3cyanine459.6CALB2, CEACAM3
4chloramphenicol45 3 51 1112.6THBD, SFTPB, MUC1, WT1
5curcumin459.5SPP1, THBD, SOD2, WT1
6calcitriol45 61 24 1112.5SPP1, THBD, SOD2, WT1
7pdtc459.4MET, SOD2, SFTPB
8agar459.3SPP1, SOD2, MUC1, MET
9matrigel459.3SPP1, THBD, MUC1, MET, CDH2
10ascorbic acid45 2410.3SPP1, THBD, SFTPB, SOD2
11adriamycin459.3SOD2, MUC1, CEACAM3, MET
12mucicarmine459.3MUC1, CEACAM3, CALB2, NKX2-1
13vitamin d459.2SPP1, THBD, SOD2, MET, WT1
14glycogen45 2410.2THBD, MUC1, MET, CDH2, CTNNA1
15bleomycin45 1110.1SOD2, SFTPB, SPP1
16ribonucleic acid459.1SPP1, SFTPB, MUC1, MET, NKX2-1, WT1
17cycloheximide459.0SPP1, THBD, SFTPB, SOD2, MET
18threonine459.0SPP1, SFTPB, MUC1, MET, NKX2-1, WT1
19butyrate459.0SPP1, SOD2, MUC1, CALB2, WT1
20actinomycin d459.0SPP1, THBD, SFTPB, SOD2, MUC1, MET
21fibrinogen459.0SPP1, THBD, SFTPB, CEACAM3
22gold458.9PDPN, CEACAM3, MUC1, SFTPB
23sialic acid458.9MUC1, CEACAM3, PDPN, CDH2
24polysaccharide458.9THBD, MUC1, PDPN, CDH2
25arginine458.8SPP1, THBD, SFTPB, SOD2, MET, WT1
2612-o-tetradecanoylphorbol 13-acetate458.8SFTPB, SOD2, MUC1, MET, WT1, CTNNA1
27creatinine458.8SPP1, THBD, SOD2, MUC1, CEACAM3, WT1
28cholesterol45 29 24 1111.8SPP1, THBD, SFTPB, MUC1, CEACAM3, MET
29dexamethasone45 51 29 1111.7SPP1, THBD, SFTPB, SOD2, MUC1, NKX2-1
30atp45 299.7SPP1, THBD, SFTPB, SOD2, MET, CDH2
31hyaluronic acid45 249.7SPP1, THBD, MUC1, MSLN, CALB2, WT1
32glucose458.6SPP1, THBD, MUC1, CEACAM3, MET, CDH2
33oxygen45 249.6SPP1, SFTPB, SOD2, MUC1, CEACAM3, MET
34lipid458.6SPP1, THBD, SFTPB, SOD2, MUC1, MET
35thymidine45 249.5SFTPB, MUC1, CEACAM3, MET, CALB2, WT1
36steroid458.5THBD, CEACAM3, MET, CALB2, NKX2-1, WT1
37retinoic acid45 249.5SPP1, THBD, SFTPB, MUC1, MET, NKX2-1
38serine458.5SPP1, THBD, SFTPB, MUC1, MET, NKX2-1
39hematoxylin458.4MUC1, CEACAM3, CALB2, NKX2-1, PDPN
40cysteine458.3SPP1, THBD, SFTPB, SOD2, MUC1, MET
41testosterone45 61 24 1111.3SPP1, SOD2, MUC1, MET, CALB2, CDH2
42oligonucleotide458.1SPP1, THBD, MSLN, MET, NKX2-1, CDH2
43nitric oxide45 24 119.9THBD, SFTPB, SOD2, MUC1, CEACAM3, MET
44progesterone45 29 61 24 1111.6SPP1, THBD, SFTPB, MUC1, CEACAM3, MET
45calcium45 51 24 1110.6SPP1, SFTPB, MUC1, CEACAM3, MET, CALB2
46estrogen457.2SPP1, THBD, MUC1, CEACAM3, MSLN, MET
47b 723457.0WT1, CDH2, PDPN, NKX2-1, CALB2, MSLN
48vegf456.1CEACAM3, MUC1, SOD2, SFTPB, THBD, SPP1
49paraffin455.7CTNNA1, WT1, CDH2, PDPN, NKX2-1, CALB2
50tyrosine455.7SPP1, THBD, SFTPB, SOD2, MUC1, CEACAM3

GO Terms for genes affiliated with Malignant Mesothelioma

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16Gene Ontology
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Cellular components related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.7CTNNA1, CDH2
2intercalated discGO:0147049.4CDH2, CTNNA1
3apical plasma membraneGO:0163249.1CDH2, PDPN, MUC1
4lamellipodiumGO:0300278.8CTNNA1, CDH2, PDPN

Biological processes related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adherens junction organizationGO:0343329.7CTNNA1, CDH2
2positive regulation of muscle cell differentiationGO:0511499.6CDH2, CTNNA1
3muscle cell differentiationGO:0426929.4CTNNA1, CDH2
4response to hyperoxiaGO:0550939.3PDPN, SOD2
5cell adhesionGO:0071558.8CTNNA1, CDH2, MSLN, SPP1

Molecular functions related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:0452959.4CTNNA1, CDH2
2protein bindingGO:0055157.5MUC1, MSLN, MET, NKX2-1, BAP1, CDH2

Products for genes affiliated with Malignant Mesothelioma

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  • Antibodies
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Sources for Malignant Mesothelioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet