MCID: MLG075
MIFTS: 58

Malignant Mesothelioma malady

Cancer, Respiratory categories

Summaries for Malignant Mesothelioma

Sources:
8Disease Ontology, 47OMIM, 33MalaCards
See all sources

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Disease Ontology:8 A cell type cancer that has material basis in meothelial tissue.

MalaCards: Malignant Mesothelioma, also known as malignant mesothelioma, susceptibility to, is related to adenocarcinoma and malignant peritoneal mesothelioma. An important gene associated with Malignant Mesothelioma is MMS (Malignant mesothelioma, susceptibility to), and among its related pathways are FGF signaling pathway and Adhesion. The compounds paraffin and vegf have been mentioned in the context of this disorder. Related mouse phenotypes are mortality/aging and cardiovascular system.

Description from OMIM:47 156240

Aliases & Classifications for Malignant Mesothelioma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Respiratory


Characteristics (Orphanet epidemiological data):

49
mesothelioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

malignant mesothelioma 8 43 47 10 45 61
malignant mesothelioma, susceptibility to 9 22
advanced malignant mesothelioma 8 61
mesothelioma, malignant 8 43
mesothelioma 49 61
asbestos-related malignant mesothelioma 8
malignant tumor of mesothelium 8
mesothelioma diffuse malignant 45
diffuse malignant mesothelioma 8


External Ids:

Disease Ontology8 DOID:1790
OMIM47 156240
NCIt40 C7865
MESH via Orphanet36 D008654
SNOMED-CT57 62064005
ICD10 via Orphanet26 C45
SNOMED-CT via Orphanet58 62064005
UMLS via Orphanet62 C0025500
ICD1025 C45, C45.9

Related Diseases for Malignant Mesothelioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Malignant Mesothelioma family:

benign intermediate mesothelioma benign mesothelioma

Diseases related to Malignant Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 248)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma31.1CALB2, SFTPB, SOD2, PDPN, WT1, CT49
2malignant peritoneal mesothelioma30.9CALB2
3benign mesothelioma30.8WT1, PDPN, CALB2, SPP1, MSLN, THBD
4wilms tumor30.5CALB2, PDPN, WT1, NKX2-1
5adenoma30.5CEACAM3, CEACAM5, MET, NKX2-1, CT49, MUC1
6adenomatoid tumor30.4WT1, CALB2
7synovial sarcoma30.4CALB2, MUC1, MET
8asbestosis30.4MSLN
9papillary carcinoma30.2NKX2-1, MET, CALB2, MUC1, CEACAM3, MUC16
10squamous cell carcinoma30.0TXN, CALB2, SFTPB, SOD2, PDPN, CT49
11colorectal cancer30.0PDPN, MET, NKX2-1, BCL2L1, TXN, CEACAM5
12pulmonary alveolar proteinosis30.0CEACAM3, MUC1, SFTPB
13stomach cancer30.0TXN, SOD2, MET, MUC1, CDH2, BCL2L1
14angiosarcoma30.0CALB2, PDPN, MUC1
15astrocytoma29.7CT49, MET, SPP1, CDH2, SOD2
16thymic carcinoma29.7MUC1, CEACAM3, NKX2-1, CALB2
17thymoma29.7CALB2, NKX2-1, TXN, CEACAM3
18renal clear cell carcinoma29.7CALB2, MET, MUC1
19mucinous cystadenocarcinoma29.7MUC16, MUC1, CEACAM3
20cystadenoma29.7CEACAM3
21vasculitis29.7THBD
22ovarian malignant mesothelioma10.6
23benign multicystic peritoneal mesothelioma10.6
24sarcomatoid mesothelioma10.5
25malignant epithelial mesothelioma10.4
26benign fibrous mesothelioma10.4
27peritoneal cystic mesothelioma10.4
28pericardial mesothelioma10.4
29malignant biphasic mesothelioma10.3
30neurofibromatosis10.3
31benign pleural mesothelioma10.3
32peritoneal carcinoma10.3
33lymphohistiocytoid mesothelioma10.2
34cardiac tamponade10.2
35papillary serous adenocarcinoma10.2
36small cell carcinoma10.2
37thrombocytosis10.2
38mesothelioma, somatic10.2
39pseudomyxoma peritonei10.1
40sarcomatosis10.1
41benign intermediate mesothelioma10.1
42bronchogenic carcinoma10.1
43solitary fibrous tumor10.1
44benign peritoneal mesothelioma10.0
45peritoneal serous papillary adenocarcinoma10.0
46lymphangitis10.0
47paragonimiasis10.0
48microcystic adenoma10.0
49kaposi's sarcoma10.0
50erysipeloid10.0

Graphical network of the top 20 diseases related to Malignant Mesothelioma:



Diseases related to malignant mesothelioma

Clinical Features for Malignant Mesothelioma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

156240

Drugs & Therapeutics for Malignant Mesothelioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Mesothelioma

Search NIH Clinical Center for Malignant Mesothelioma

Search CenterWatch for Malignant Mesothelioma

Genetic Tests for Malignant Mesothelioma

Sources:
22GTR
See all sources

Genetic tests related to Malignant Mesothelioma:

id Genetic test Affiliating Genes
1 Mesothelioma, Malignant22

Anatomical Context for Malignant Mesothelioma

Animal Models for Malignant Mesothelioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Malignant Mesothelioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.5TXN, SFTPB, SOD2, PDPN, WT1, MET
2MP:000538511.2SOD2, PDPN, WT1, MET, NKX2-1, BAP1
3MP:000200611.1SOD2, MET, NKX2-1, BAP1, MUC1, SPP1
4MP:000537611.0SPP1, THBD, CDH2, BAP1, PDPN
5MP:000537010.9WT1, MET, MUC1, THBD, SPP1, SOD2
6MP:000537810.9SOD2, PDPN, WT1, MET, NKX2-1, BAP1
7MP:000538810.9SFTPB, PDPN, MET, THBD, SPP1
8MP:000536910.8WT1, MET, BAP1, CDH2, SPP1

Publications for Malignant Mesothelioma

Sources:
51PubMed
See all sources

Articles related to Malignant Mesothelioma:

(show top 50)    (show all 1572)
idTitleAuthorsYear
1
Small orangiophilic squamous-like cells: An underrecognized and useful morphological feature for the diagnosis of malignant mesothelioma in pleural effusion cytology. (23983174)
2014
2
Estrogen receptor I^ activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo. (24061575)
2013
3
Radiotherapy for the treatment of pain in malignant pleural mesothelioma: A systematic review. (24314815)
2013
4
Fowlpox-based survivin vaccination for malignant mesothelioma therapy. (23335100)
2013
5
The usefulness of expert opinion in medicolegal referrals of malignant mesothelioma. (23856848)
2013
6
Management of malignant pleural mesothelioma: have we made any progress? (23676957)
2013
7
Quantitative X-ray computed tomography peritoneography in malignant peritoneal mesothelioma patients receiving intraperitoneal chemotherapy. (23702640)
2013
8
Photodynamic therapy for malignant pleural mesothelioma. (23055222)
2012
9
Three-dimensional stereoscopic volume rendering of malignant pleural mesothelioma. (23102002)
2012
10
First-line chemotherapy with liposomal doxorubicin plus cisplatin for patients with advanced malignant pleural mesothelioma: phase II trial. (22353806)
2012
11
Pretreatment serum C-reactive protein levels predict benefit from multimodality treatment including radical surgery in malignant pleural mesothelioma: a retrospective multicenter analysis. (22750759)
2012
12
PDGF-D/PDGF-I^I^ receptor-regulated chemotaxis of malignant mesothelioma cells. (22415093)
2012
13
Diffuse malignant peritoneal mesothelioma--an update on treatment. (22104079)
2012
14
Optimization of response classification criteria for patients with malignant pleural mesothelioma. (23059782)
2012
15
Extrapleural pneumonectomy for early stage malignant pleural mesothelioma: a harmful procedure. (22244608)
2012
16
Is I+7-nAChR a possible target for lung cancer and malignant pleural mesothelioma treatment? (22300036)
2012
17
Long term survival after trimodal therapy in malignant pleural mesothelioma. (23135895)
2012
18
Oral presentation of malignant mesothelioma. (20813558)
2011
19
Coactivation of receptor tyrosine kinases in malignant mesothelioma as a rationale for combination targeted therapy. (21774103)
2011
20
Epidermal growth factor receptor overexpression in malignant pleural mesothelioma: prognostic correlations. (21437912)
2011
21
XRCC1 and ERCC1 variants modify malignant mesothelioma risk: a case-control study. (21277872)
2011
22
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. (21642991)
2011
23
Malignant mesothelioma of the spermatic cord. (21461290)
2011
24
Premature senescence induced by DNA demethylating agent (Decitabine) as therapeutic option for malignant pleural mesothelioma. (21095037)
2011
25
Immunohistochemical profile of paratesticular serous papillary adenocarcinoma and tunica vaginalis facilitates distinction from malignant mesothelioma. (19493919)
2011
26
High-dose-rate surface brachytherapy to boost elongated, curvilinear incisional scars after extrapleural pneumonectomy for malignant pleural mesothelioma treated with adjuvant intensity-modulated radiation therapy. (19846346)
2010
27
Estrogen receptor I^ exerts tumor repressive functions in human malignant pleural mesothelioma via EGFR inactivation and affects response to gefitinib. (21124760)
2010
28
A Phosphotyrosine Proteomic Screen Identifies Multiple Tyrosine Kinase Signaling Pathways Aberrantly Activated in Malignant Mesothelioma. (20672017)
2010
29
Proton therapy for malignant pleural mesothelioma after extrapleural pleuropneumonectomy. (20385451)
2010
30
Colonic invasion of malignant peritoneal mesothelioma. (19913225)
2010
31
Impact of malignant mesothelioma in Taiwan: a 27-year review of population-based cancer registry data. (19535165)
2010
32
Tenascin-X is a novel diagnostic marker of malignant mesothelioma. (19738457)
2009
33
Malignant pleural mesothelioma presenting as low back pain: diagnosed by bone scan coordinating with F-18 FDG PET/CT. (19934799)
2009
34
Pooled analysis of NAT2 genotypes as risk factors for asbestos-related malignant mesothelioma. (18838334)
2009
35
9p21 Deletion in the diagnosis of malignant mesothelioma in serous effusions additional to immunocytochemistry, DNA-ICM, and AgNOR analysis. (18306350)
2008
36
Primary pleural neoplasia: entities other than diffuse malignant mesothelioma. (18605768)
2008
37
Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma. (18375821)
2008
38
Primary malignant mesothelioma of the abdominal wall: complete response with radiotherapy alone. (18198923)
2008
39
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
40
Expression of Snail, Slug and Sip1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression. (16996643)
2006
41
Adjuvant malignant mesothelioma radiotherapy: How many difficulties! In regard to: Allen et al. Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma (Int J Radiat Oncol Biol Phys 2006;65:640-645) and Gupta et al. Hemithoracic radiation therapy after pleurectomy/decortication for malignant pleural mesothelioma (Int J Radiat Oncol Biol Phys 2005;63:1045-1052). (17145545)
2006
42
Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. (15337769)
2004
43
Primary epithelial malignant mesothelioma of the pericardium with deciduoid features: cytohistologic and immunohistochemical study. (11813331)
2002
44
The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma. (11697834)
2001
45
Malignant peritoneal mesothelioma presenting with respiratory symptoms. (10823639)
2000
46
An autopsy case of a malignant pericardial mesothelioma in a Japanese young man. (10504529)
1999
47
A phase II trial of interferon alpha-2a and carboplatin in patients with advanced malignant mesothelioma. (10099658)
1999
48
Comparison of silver-staining nucleolar organizer region (AgNOR) counts and proliferating cell nuclear antigen (PCNA) expression in reactive mesothelial hyperplasia and malignant mesothelioma. (7603742)
1995
49
Occurrence of malignant peritoneal mesothelioma after surgery and irradiation for cervical cancer. (6706236)
1984
50
Malignant peritoneal mesothelioma with massive foamy cells. Codfish roe-like mesothelioma. (6464757)
1984

Genetic Variations for Malignant Mesothelioma

Expression for genes affiliated with Malignant Mesothelioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malignant Mesothelioma

Search GEO for disease gene expression data for Malignant Mesothelioma.

Pathways for genes affiliated with Malignant Mesothelioma

Sources:
38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Pathways related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7SPP1, CDH2, MET
210.7CEACAM5, CDH2, MUC1

Compounds for genes affiliated with Malignant Mesothelioma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Malignant Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1paraffin4512.1CEACAM3, SOD2, SFTPB, CALB2, PDPN, WT1
2vegf4512.1SOD2, PDPN, WT1, CT49, MET, MUC16
3tyrosine4512.0SPP1, PDPN, CALB2, MUC16, SFTPB, WT1
4progesterone45 60 29 11 2415.9CEACAM5, CEACAM3, SPP1, THBD, CDH2, MUC1
5cysteine4511.8MUC1, CDH2, SOD2, SPP1, BCL2L1, CEACAM5
6b 7234511.7NKX2-1, CEACAM5, CEACAM3, MSLN, THBD, CDH2
7retinoic acid45 2412.7CDH2, MUC1, NKX2-1, TXN, SFTPB, CT49
8testosterone45 60 11 2414.6CDH2, CT49, SPP1, TXN, CALB2, SOD2
9oligonucleotide4511.5MET, SPP1, MSLN, THBD, CDH2, NKX2-1
10hyaluronic acid45 2412.5MUC16, SPP1, MSLN, THBD, CEACAM5, MUC1
11actinomycin d4511.5BCL2L1, TXN, SFTPB, SOD2, MET, MUC1
12dexamethasone45 50 29 1114.5SFTPB, CDH2, MUC16, BCL2L1, TXN, SPP1
13doxorubicin45 50 1113.5WT1, SOD2, MUC16, CEACAM3, BCL2L1, TXN
14thymidine45 2412.4CEACAM5, CEACAM3, MUC1, CALB2, CT49, WT1
15cisplatin45 50 60 1114.4SPP1, TXN, SOD2, MET, MUC16, MUC1
16hematoxylin4511.4CALB2, PDPN, NKX2-1, MUC16, CEACAM5, MUC1
17nitric oxide45 11 2413.4THBD, MUC1, MET, WT1, SOD2, SFTPB
18adriamycin4511.4MUC1, BCL2L1, SOD2, TXN, CEACAM5, CEACAM3
19threonine4511.4MET, SPP1, WT1, SFTPB, MUC1, MUC16
20serine4511.4NKX2-1, CT49, WT1, CDH2, MUC16, SFTPB
21ribonucleic acid4511.4SFTPB, MET, NKX2-1, MUC1, SPP1, CEACAM5
22steroid4511.4THBD, CT49, NKX2-1, MUC16, CALB2, CEACAM3
23agar4511.4SOD2, TXN, CT49, MET, SPP1, CEACAM5
24atp45 2912.3BCL2L1, SFTPB, SOD2, CT49, MET, CDH2
25lactate4511.3TXN, SOD2, MUC16, THBD, SPP1, CEACAM3
26gold4511.3CEACAM3, CEACAM5, PDPN, MUC1, MUC16, SFTPB
27creatinine4511.3CEACAM3, THBD, MUC16, WT1, TXN, SPP1
28mucicarmine4511.3NKX2-1, CEACAM3, CEACAM5, MUC1, CALB2
29matrigel4511.3SPP1, THBD, BCL2L1, CDH2, MUC1, MET
30cholesterol45 29 11 2414.3SPP1, THBD, MUC1, SFTPB, MET, CEACAM3
31vitamin d4511.3TXN, SOD2, WT1, MET, THBD, SPP1
32glucose4511.2MET, MUC16, MUC1, THBD, CDH2, CEACAM3
33oxygen45 2412.2TXN, MET, CEACAM3, MUC1, BCL2L1, SFTPB
34curcumin4511.2BCL2L1, SPP1, SOD2, THBD, WT1
35mptp4511.1SOD2, SPP1, BCL2L1, TXN
36lipid4511.1THBD, CDH2, MUC1, MET, CEACAM5, SFTPB
37sialic acid4511.1CDH2, CEACAM3, CEACAM5
385fluorouracil4511.0MUC1, CEACAM5, CEACAM3, SOD2, BCL2L1
39chloramphenicol45 2 1113.0MUC1, TXN, THBD, WT1, SFTPB
40manganese superoxide4511.0BCL2L1, SOD2, SFTPB, TXN
41arginine4511.0SOD2, SFTPB, MET, TXN, WT1, THBD
42estrogen4511.0CALB2
43pdtc4511.0SFTPB, SOD2, MET, BCL2L1
44butyrate4511.0SOD2, CALB2
45cycloheximide4510.9SFTPB, SOD2
46retinoid4510.9SPP1, BCL2L1, THBD, SFTPB, TXN
47alanine4510.9THBD, TXN, SPP1, SOD2, CT49, CEACAM3
48metronidazole45 1111.8CEACAM3, MUC1, CEACAM5
49bleomycin45 1111.7SFTPB
50ascorbic acid45 2411.5SOD2, SFTPB, TXN, SPP1, THBD

GO Terms for genes affiliated with Malignant Mesothelioma

Sources:
16Gene Ontology
See all sources

Biological processes related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hyperoxiaGO:05509310.6PDPN, SOD2
2response to selenium ionGO:01026910.3SOD2, TXN

Products for genes affiliated with Malignant Mesothelioma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Malignant Mesothelioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet