MCID: MLG075
MIFTS: 69

Malignant Mesothelioma malady

Cancer diseases, Respiratory diseases categories

Summaries for Malignant Mesothelioma

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8Disease Ontology, 46OMIM, 32MalaCards
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Disease Ontology:8 A cell type cancer that has material basis in meothelial tissue.

MalaCards: Malignant Mesothelioma, also known as malignant mesothelioma, susceptibility to, is related to malignant pleural mesothelioma and adenocarcinoma. An important gene associated with Malignant Mesothelioma is MMS (Malignant mesothelioma, susceptibility to), and among its related pathways are FGF signaling pathway and Adhesion. The compounds paraffin and vegf have been mentioned in the context of this disorder. Affiliated tissues include lung, testis and endothelial, and related mouse phenotypes are mortality/aging and cardiovascular system.

Description from OMIM:46 156240

Aliases & Classifications for Malignant Mesothelioma

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Sources:
48Orphanet, 60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 9diseasecard, 22GTR, 56SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
mesothelioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

malignant mesothelioma 8 42 46 10 44 60
malignant mesothelioma, susceptibility to 9 22
advanced malignant mesothelioma 8 60
mesothelioma, malignant 8 42
mesothelioma 48 60
asbestos-related malignant mesothelioma 8
malignant tumor of mesothelium 8
diffuse malignant mesothelioma 8
mesothelioma diffuse malignant 44


External Ids:

Disease Ontology8 DOID:1790
OMIM46 156240
NCIt39 C7865
MESH via Orphanet35 D008654
SNOMED-CT56 62064005
ICD10 via Orphanet26 C45
SNOMED-CT via Orphanet57 62064005
UMLS via Orphanet61 C0025500
ICD1025 C45, C45.9

Related Diseases for Malignant Mesothelioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malignant Mesothelioma family:

Benign Intermediate Mesothelioma Benign Mesothelioma

Diseases related to Malignant Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1malignant pleural mesothelioma31.3CDH2, THBD, MSLN, SPP1, BCL2L1, CEACAM3
2adenocarcinoma31.1CT49, MET, NKX2-1, MUC16, MUC1, CDH2
3malignant peritoneal mesothelioma30.9CALB2
4peritonitis30.8MUC16
5benign mesothelioma30.7SPP1, CALB2, PDPN, WT1, NKX2-1, THBD
6lung adenocarcinoma30.7BCL2L1, CEACAM3, CEACAM5, SPP1, MSLN, TXN
7lung cancer30.6TXN, SFTPB, SOD2, MET, NKX2-1, MSLN
8leukemia30.5BCL2L1, CDH2, WT1
9sarcoma30.4MUC1, MET, WT1, SOD2, CALB2
10melanoma30.3TXN, CALB2, SOD2, PDPN, CT49, MET
11ovarian cancer30.3TXN, CALB2, MET, MUC16, MUC1, CDH2
12adenomatoid tumor30.3CALB2, WT1
13synovial sarcoma30.3CALB2, MET, MUC1
14asbestosis30.3MSLN
15papillary adenocarcinoma30.2NKX2-1, MUC16, MUC1, CEACAM5
16papillary carcinoma30.1CALB2, SOD2, MET, NKX2-1, MUC16, MUC1
17cystadenocarcinoma30.0MUC16, MUC1, CEACAM3, CEACAM5
18squamous cell carcinoma30.0CALB2, SFTPB, SOD2, PDPN, CT49, MET
19breast cancer30.0BAP1, MET, PDPN, SOD2, TXN, MUC16
20lung small cell carcinoma30.0CALB2, CT49, MET, NKX2-1, MUC1, CDH2
21colorectal cancer30.0TXN, PDPN, MET, NKX2-1, BCL2L1, CEACAM3
22non-small cell lung carcinoma30.0SFTPB, MET, NKX2-1, BCL2L1, CEACAM5
23pulmonary alveolar proteinosis30.0SFTPB, MUC1, CEACAM3
24non-hodgkin lymphoma30.0SOD2, CT49, MUC16, BCL2L1
25esophagitis30.0SOD2
26pancreatitis30.0SOD2
27interstitial lung disease30.0MUC1
28hepatitis30.0SOD2
29pericardial effusion30.0MUC16
30hepatocellular carcinoma29.9MET, CT49, SOD2, TXN, NKX2-1, CDH2
31stomach cancer29.9CDH2, MUC1, MET, SOD2, TXN, BCL2L1
32osteosarcoma29.9SPP1, CDH2, MET, CT49
33retinoblastoma29.9BCL2L1, CDH2, CT49, WT1
34endometriosis29.9CDH2, MUC16, CALB2
35angiosarcoma29.9MUC1, PDPN, CALB2
36cervical cancer29.9MUC16, PDPN
37nephrotic syndrome29.9WT1
38glioblastoma multiforme29.7SOD2, PDPN, CT49, MET, CDH2, BCL2L1
39endometrial carcinoma29.7CALB2, NKX2-1, MUC16, CDH2, CEACAM5
40astrocytoma29.7SOD2, CT49, MET, CDH2, SPP1
41thymoma29.7TXN, CALB2, NKX2-1, CEACAM3
42papillary thyroid carcinoma29.7CT49, MET, NKX2-1, SPP1
43hemangioma29.7SFTPB, PDPN, NKX2-1
44renal clear cell carcinoma29.7CALB2, MET, MUC1
45chondrosarcoma29.7CEACAM3, MUC1, MET
46mucinous cystadenocarcinoma29.7CEACAM3, MUC1, MUC16
47cystadenoma29.7CEACAM3
48leiomyoma29.7CDH2
49vasculitis29.7THBD
50ovarian malignant mesothelioma10.5

Graphical network of the top 20 diseases related to Malignant Mesothelioma:



Diseases related to malignant mesothelioma

Clinical Features for Malignant Mesothelioma

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46OMIM
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Clinical features from OMIM:

156240

Drugs & Therapeutics for Malignant Mesothelioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Mesothelioma

Search NIH Clinical Center for Malignant Mesothelioma

Search CenterWatch for Malignant Mesothelioma

Genetic Tests for Malignant Mesothelioma

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Sources:
22GTR
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Genetic tests related to Malignant Mesothelioma:

id Genetic test Affiliating Genes
1 Mesothelioma, Malignant22

Anatomical Context for Malignant Mesothelioma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Malignant Mesothelioma:

32
Lung, Testis, Endothelial, Lymph node, T cells, Breast, Testes, Brain, Bone, Colon, Liver, Skin, Pancreas, Placenta, Thyroid, Monocytes, B cells, Kidney, Spinal cord, Tongue, Appendix

Animal Models for Malignant Mesothelioma or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Malignant Mesothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.5TXN, SFTPB, SOD2, PDPN, WT1, MET
2MP:000538511.2SOD2, PDPN, WT1, MET, NKX2-1, BAP1
3MP:000200611.1SOD2, MET, NKX2-1, BAP1, MUC1, SPP1
4MP:000537611.0SPP1, THBD, CDH2, BAP1, PDPN
5MP:000537010.9WT1, MET, MUC1, THBD, SPP1, SOD2
6MP:000537810.9SOD2, PDPN, WT1, MET, NKX2-1, BAP1
7MP:000538810.9SFTPB, PDPN, MET, THBD, SPP1
8MP:000536910.8WT1, MET, BAP1, CDH2, SPP1

Publications for Malignant Mesothelioma

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50PubMed
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Articles related to Malignant Mesothelioma:

(show top 50)    (show all 1576)
idTitleAuthorsYear
1
ERCC1, MLH1, MSH2, MSH6, and I^III-tubulin: resistance proteins associated with response and outcome to platinum-based chemotherapy in malignant pleural mesothelioma. (23810210)
2013
2
Malignant peritoneal mesothelioma (MPM) who responded to rechallenge with cisplatin and pemetrexed with current literature review. (23291819)
2013
3
Leser-TrAclat syndrome in malignant mesothelioma and pulmonary adenocarcinoma: is the EGFR pathway part of the syndrome? (24233154)
2013
4
No detection of simian virus 40 in malignant mesothelioma in Korea. (23667371)
2013
5
Effects of cisplatin and panobinostat on human mesothelial (Met-5A) and malignant pleural mesothelioma (MSTO-211H) cells. (24301913)
2013
6
Combination of mesothelin and CEA significantly improves the differentiation between malignant pleural mesothelioma, benign asbestos disease, and lung cancer. (23777840)
2013
7
Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis. (22208496)
2012
8
Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis. (22412141)
2012
9
A case report of an extremely rare and aggressive tumor: primary malignant pericardial mesothelioma. (22826778)
2012
10
Inflammation-based prognostic indices in malignant pleural mesothelioma. (22307011)
2012
11
G-CSF-producing malignant pleural mesothelioma: an autopsy case report with literature review. (21911431)
2012
12
Comprehensive treatment of malignant mesothelioma patients after the failure of systemic chemotherapy. (22939880)
2012
13
Malignant pleural mesothelioma presenting as rectal polyp: a case report and review of the literature. (23112886)
2012
14
MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells. (23155254)
2012
15
Epithelial-mesenchymal transition in malignant mesothelioma. (21983934)
2012
16
Malignant peritoneal mesothelioma presented as peritoneal adenocarcinoma or primary ovarian cancer: case series and review of the clinical and immunohistochemical features. (22808303)
2012
17
EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene. (21869823)
2011
18
Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma. (21300430)
2011
19
Malignant pleural mesothelioma in Singapore. (21875258)
2011
20
Volumetry: an alternative to assess therapy response for malignant pleural mesothelioma? (21273389)
2011
21
Quantitative measurement of lung reexpansion in malignant pleural mesothelioma patients undergoing pleurectomy/decortication. (21145765)
2011
22
The sensitivity of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma. (20049969)
2010
23
Successful salvage chemotherapy with gemcitabine and vinorelbine in a malignant pleural mesothelioma patient previously treated with pemetrexed. (20603247)
2010
24
Malignant peritoneal mesothelioma]. (20445731)
2010
25
Malignant Mesothelioma in the Thoracic Cavity of a Crj:CD(SD) Rat Characterized by Round Hyalinous Stroma. (22272019)
2010
26
Placenta growth factor expression has prognostic value in malignant pleural mesothelioma. (19632388)
2009
27
Expression of GATA-6 transcription factor in pleural malignant mesothelioma and metastatic pulmonary adenocarcinoma. (19060016)
2009
28
Late cutaneous metastases to the face from malignant pleural mesothelioma: a case report and review of the literature. (19900274)
2009
29
Cytogenetics and fluorescence in situ hybridization as adjuncts to cytology in the diagnosis of malignant mesothelioma. (19536878)
2009
30
Lymph node dissection in primary intrahepatic malignant mesothelioma: case report and implications for diagnosis and therapy. (19280219)
2009
31
Novel and existing mutations in the tyrosine kinase domain of the epidermal growth factor receptor are predictors of optimal resectability in malignant peritoneal mesothelioma. (18998063)
2009
32
Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2. (18754873)
2008
33
Genetic susceptibility to malignant mesothelioma and exposure to asbestos: the influence of the familial factor. (17904414)
2008
34
Acquisition of cisplatin-resistance in malignant mesothelioma cells abrogates Na+,K+,2Cl(-)-cotransport activity and cisplatin-induced early membrane blebbing. (18769031)
2008
35
New diagnostic and molecular characteristics of malignant mesothelioma. (19117264)
2008
36
Renal cell carcinoma with malignant pleural mesothelioma after asbestos exposure: a case report]. (18051806)
2007
37
Malignant mesothelioma of the pleura and other malignancies in the same patient. (17455866)
2007
38
Malignant mesothelioma masquerading as a multinodular bronchioloalveolar cell adenocarcinoma with widespread pulmonary nodules. (16959710)
2006
39
Dramatic tumour response to pemetrexed single-agent in an elderly patient with malignant peritoneal mesothelioma: a case report. (17176466)
2006
40
Malignant mesothelioma of the spermatic cord: case report and review of the literature. (17629883)
2005
41
Abdominal computed tomography scans in the selection of patients with malignant peritoneal mesothelioma for comprehensive treatment with cytoreductive surgery and perioperative intraperitoneal chemotherapy. (15637690)
2005
42
Quinidine impairs proliferation of neurofibromatosis type 2-deficient human malignant mesothelioma cells. (12673723)
2003
43
Palliative and therapeutic activity of IL-2 immunotherapy in unresectable malignant pleural mesothelioma with pleural effusion: Results of a phase II study on 31 consecutive patients. (11165411)
2001
44
Endothelial nitric oxide synthase is strongly expressed in malignant mesothelioma but does not associate with vascular density or the expression of VEGF, FLK1 or FLT1. (11493335)
2001
45
Proteoglycans in human malignant mesothelioma. Stimulation of their synthesis induced by epidermal, insulin and platelet-derived growth factors involves receptors with tyrosine kinase activity. (10492020)
1999
46
Malignant peritoneal mesothelioma. (10547260)
1998
47
Gene therapy of experimental malignant mesothelioma using adenovirus vectors encoding the HSVtk gene. (9176512)
1997
48
Primary malignant pericardial mesothelioma: a case report and review. (8040178)
1994
49
Establishment and characterization of five human malignant mesothelioma cell lines derived from pleural effusions. (1703129)
1991
50
Diffuse malignant peritoneal mesothelioma presenting as acute appendicitis. (6585690)
1984

Genetic Variations for Malignant Mesothelioma

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Expression for genes affiliated with Malignant Mesothelioma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Mesothelioma

Search GEO for disease gene expression data for Malignant Mesothelioma.

Pathways for genes affiliated with Malignant Mesothelioma

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Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7SPP1, CDH2, MET
210.7CEACAM5, CDH2, MUC1

Compounds for genes affiliated with Malignant Mesothelioma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Malignant Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1paraffin4412.1CALB2, SFTPB, SOD2, PDPN, WT1, CT49
2vegf4412.1WT1, CT49, MET, MUC16, MUC1, CDH2
3tyrosine4412.0MET, WT1, PDPN, SOD2, SFTPB, CALB2
4progesterone44 59 28 11 2415.9MET, NKX2-1, MUC16, MUC1, CDH2, THBD
5cysteine4411.8CT49, WT1, SOD2, SFTPB, TXN, MET
6b 7234411.7CALB2, PDPN, WT1, NKX2-1, MUC16, MUC1
7retinoic acid44 2412.7CT49, WT1, SFTPB, TXN, MET, NKX2-1
8testosterone44 59 11 2414.6TXN, CALB2, SOD2, WT1, CT49, MET
9oligonucleotide4411.5WT1, CT49, MET, NKX2-1, CDH2, THBD
10hyaluronic acid44 2412.5CALB2, WT1, MUC16, MUC1, THBD, MSLN
11actinomycin d4411.5TXN, SFTPB, SOD2, MET, MUC1, THBD
12dexamethasone44 49 28 1114.5TXN, SFTPB, SOD2, NKX2-1, MUC16, CDH2
13doxorubicin44 49 1113.5TXN, SOD2, WT1, MET, MUC16, BCL2L1
14thymidine44 2412.4CALB2, SFTPB, WT1, CT49, MET, MUC1
15cisplatin44 49 59 1114.4TXN, SOD2, MET, MUC16, MUC1, SPP1
16hematoxylin4411.4CALB2, PDPN, NKX2-1, MUC16, MUC1, CEACAM3
17nitric oxide44 11 2413.4CALB2, SFTPB, SOD2, WT1, MET, MUC1
18adriamycin4411.4TXN, SOD2, MET, MUC1, BCL2L1, CEACAM3
19threonine4411.4SFTPB, WT1, MET, NKX2-1, MUC16, MUC1
20serine4411.4TXN, SFTPB, WT1, CT49, NKX2-1, MUC16
21ribonucleic acid4411.4SFTPB, WT1, MET, NKX2-1, MUC1, SPP1
22steroid4411.4CALB2, WT1, CT49, NKX2-1, MUC16, THBD
23agar4411.4TXN, SOD2, CT49, MET, MUC1, SPP1
24atp44 2812.3SFTPB, SOD2, CT49, MET, CDH2, THBD
25lactate4411.3TXN, SOD2, MUC16, THBD, SPP1, CEACAM3
26gold4411.3SFTPB, PDPN, MUC16, MUC1, CEACAM3, CEACAM5
27creatinine4411.3TXN, WT1, MUC16, THBD, SPP1, CEACAM3
28mucicarmine4411.3CALB2, NKX2-1, MUC1, CEACAM3, CEACAM5
29matrigel4411.3MET, MUC1, CDH2, THBD, SPP1, BCL2L1
30cholesterol44 28 11 2414.3SFTPB, MET, MUC1, THBD, SPP1, CEACAM3
31vitamin d4411.3TXN, SOD2, WT1, MET, THBD, SPP1
32glucose4411.2MET, MUC16, MUC1, CDH2, THBD, CEACAM3
33oxygen44 2412.2TXN, SFTPB, MET, MUC1, BCL2L1, CEACAM3
34curcumin4411.2SOD2, WT1, THBD, SPP1, BCL2L1
35mptp4411.1TXN, SOD2, SPP1, BCL2L1
36lipid4411.1SOD2, MET, MUC1, CDH2, THBD, SPP1
37sialic acid4411.1CDH2, CEACAM3, CEACAM5
385fluorouracil4411.0SOD2, MUC1, BCL2L1, CEACAM3, CEACAM5
39chloramphenicol44 2 1113.0TXN, SFTPB, WT1, MUC1, THBD
40manganese superoxide4411.0TXN, SFTPB, SOD2, BCL2L1
41arginine4411.0TXN, SFTPB, SOD2, WT1, MET, THBD
42estrogen4411.0CALB2
43pdtc4411.0BCL2L1, MET, SOD2, SFTPB
44butyrate4411.0SOD2, CALB2
45cycloheximide4410.9SOD2, SFTPB
46retinoid4410.9TXN, SFTPB, THBD, SPP1, BCL2L1
47alanine4410.9TXN, SOD2, CT49, MET, THBD, SPP1
48metronidazole44 1111.8MUC1, CEACAM3, CEACAM5
49bleomycin44 1111.7SFTPB
50ascorbic acid44 2411.5TXN, SFTPB, SOD2, THBD, SPP1

GO Terms for genes affiliated with Malignant Mesothelioma

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16Gene Ontology
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Biological processes related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hyperoxiaGO:05509310.6PDPN, SOD2
2response to selenium ionGO:01026910.3SOD2, TXN

Products for genes affiliated with Malignant Mesothelioma

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Sources for Malignant Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet