MCID: MLG075
MIFTS: 69

Malignant Mesothelioma malady

Rare diseases, Cancer diseases, Respiratory diseases categories
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Summaries for Malignant Mesothelioma

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MedlinePlus:33 The tissue that lines your lungs, stomach, heart, and other organs is called mesothelium. mesothelioma is a tumor of that tissue. it usually starts in the lungs, but can also start in the abdomen or other organs. it can be benign (not cancer) or malignant (cancer.) malignant mesothelioma is a rare but serious type of cancer. most people who get it have worked on jobs where they inhaled asbestos particles. after being exposed to asbestos, it usually takes a long time for the disease to form. symptoms include trouble breathing pain under the rib cage pain, swelling, or lumps in the abdomen weight loss for no known reason sometimes it is hard to tell the difference between malignant mesothelioma and lung cancer. your doctor uses imaging tests and a biopsy to make the diagnosis. malignant mesothelioma is often found when it is advanced. this makes it harder to treat. treatment may include surgery, radiation, and/or chemotherapy. nih: national cancer institute

MalaCards based summary: Malignant Mesothelioma, also known as mesothelioma, is related to malignant pleural mesothelioma and adenomatoid tumor. An important gene associated with Malignant Mesothelioma is MMS (Malignant mesothelioma, susceptibility to), and among its related pathways are N-cadherin signaling events and CDO in myogenesis. The compounds indium and polyethylene glycol have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testis, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Disease Ontology:8 A cell type cancer that has material basis in mesothelial tissue.

Wikipedia:65 Mesothelioma (or, more precisely, malignant mesothelioma) is a rare form of cancer that develops from... more...

Description from OMIM:46 156240

Aliases & Classifications for Malignant Mesothelioma

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Sources:
8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 27ICD9CM, 39NCIt, 34MeSH, 57SNOMED-CT, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Malignant Mesothelioma, Aliases & Descriptions:

Name: Malignant Mesothelioma 8 42 46 10 44 62
Mesothelioma 48 33 62
Asbestos-Related Malignant Mesothelioma 8 62
Advanced Malignant Mesothelioma 8 62
Malignant Tumor of Mesothelium 8 62
 
Mesothelioma, Malignant 42 22
Malignant Mesothelioma, Susceptibility to 9
Mesothelioma Diffuse Malignant 44
Diffuse Malignant Mesothelioma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
mesothelioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:1790
ICD9CM27 163
NCIt39 C7865
OMIM46 156240
MeSH34 D008654
SNOMED-CT57 62064005
MESH via Orphanet35 D008654
ICD10 via Orphanet26 C45
UMLS via Orphanet63 C0025500
ICD1025 C45, C45.9

Related Diseases for Malignant Mesothelioma

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Diseases in the Malignant Mesothelioma family:

Benign Intermediate Mesothelioma Benign Mesothelioma

Diseases related to Malignant Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1malignant pleural mesothelioma31.1MSLN, CALB2
2adenomatoid tumor31.1WT1, CALB2
3papillary adenocarcinoma30.9MUC1, NKX2-1
4malignant peritoneal mesothelioma30.8CALB2
5wilms tumor30.7CALB2, NKX2-1, PDPN, WT1
6synovial sarcoma30.7CALB2, MET, MUC1
7cystadenocarcinoma30.7CEACAM3, MUC1
8lung cancer30.6MUC1, MET, NKX2-1
9interstitial lung disease30.5NKX2-1, SFTPB
10angiosarcoma30.4MUC1, CALB2, PDPN
11pulmonary alveolar proteinosis30.4CEACAM3, MUC1, SFTPB
12epithelioid sarcoma30.4MUC1, CALB2
13benign mesothelioma30.4WT1, PDPN, NKX2-1, CALB2, MSLN, THBD
14malignant peripheral nerve sheath tumor30.3MUC1, MET
15mucinous cystadenocarcinoma30.3CEACAM3, MUC1
16non-small cell lung carcinoma30.2SFTPB, MET, NKX2-1
17hemangioma30.1SFTPB, NKX2-1, PDPN
18sarcoma30.0WT1, CALB2, MET, MUC1, SOD2
19papillary thyroid carcinoma30.0MET, SPP1
20endometrial carcinoma29.9CALB2, NKX2-1, CDH2
21thymoma29.8CTNNA1, NKX2-1, CALB2, CEACAM3
22colorectal cancer29.6MUC1, CEACAM3, MET, PDPN, CTNNA1
23chondrosarcoma29.6MUC1, CEACAM3, MET, CTNNA1
24ovarian cancer29.5SPP1, MUC1, CEACAM3, MSLN, MET, CALB2
25papillary carcinoma29.3SOD2, MUC1, CEACAM3, MET, CALB2, NKX2-1
26glioblastoma28.9SOD2, MET, PDPN, CDH2, CTNNA1
27astrocytoma28.9CTNNA1, CDH2, MET, SOD2, SPP1
28melanoma28.7SPP1, SOD2, CEACAM3, MET, CALB2, NKX2-1
29stomach cancer28.6SPP1, SOD2, CEACAM3, MET, PDPN, CDH2
30adenocarcinoma28.4CDH2, PDPN, NKX2-1, CALB2, MET, MSLN
31breast cancer28.2SPP1, SOD2, MUC1, CEACAM3, MSLN, MET
32lung adenocarcinoma28.2SFTPB, THBD, SPP1, SOD2, MUC1, CTNNA1
33benign multicystic peritoneal mesothelioma10.6
34peritonitis10.6
35sclerosing hemangioma10.5SFTPB
36metanephric adenoma10.5WT1
37peritoneal cystic mesothelioma10.5
38osteofibrous dysplasia10.4SPP1
39benign fibrous mesothelioma10.4
40leukemia10.4
41sertoli cell tumor10.4MUC1, CALB2
42desmoplastic small round cell tumor10.4MUC1, WT1
43peritoneal mesothelioma10.4
44endotheliitis10.4
45merkel cell carcinoma10.4MUC1, NKX2-1
46ovarian brenner tumor10.4WT1, THBD
47congenital diaphragmatic hernia10.4SFTPB
48cutaneous paget's disease10.4MUC1, CEACAM3
49adenosquamous carcinoma10.4MUC1, NKX2-1
50syringoma10.4MUC1, CEACAM3

Graphical network of the top 20 diseases related to Malignant Mesothelioma:



Diseases related to malignant mesothelioma

Symptoms for Malignant Mesothelioma

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Clinical features from OMIM:

156240

Drugs & Therapeutics for Malignant Mesothelioma

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Drug clinical trials:

Search ClinicalTrials for Malignant Mesothelioma

Search NIH Clinical Center for Malignant Mesothelioma

Genetic Tests for Malignant Mesothelioma

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Genetic tests related to Malignant Mesothelioma:

id Genetic test Affiliating Genes
1 Mesothelioma, Malignant22

Anatomical Context for Malignant Mesothelioma

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MalaCards organs/tissues related to Malignant Mesothelioma:

32
Lung, Heart, Testis, Testes, Breast, Endothelial, T cells, Bone, Neutrophil, Lymph node, Brain, Colon, Liver, Pancreas, Thyroid, Skin, Kidney, Placenta, Monocytes, B cells, Appendix

Animal Models for Malignant Mesothelioma or affiliated genes

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Publications for Malignant Mesothelioma

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Articles related to Malignant Mesothelioma:

(show top 50)    (show all 719)
idTitleAuthorsYear
1
Overview of the biochemical and genetic processes in malignant mesothelioma. (25210967)
2014
2
CREB-induced inflammation is important for malignant mesothelioma growth. (25111229)
2014
3
Low PIAS3 Expression in Malignant Mesothelioma Is Associated with Increased STAT3 Activation and Poor Patient Survival. (25124686)
2014
4
Diffuse intrapulmonary malignant mesothelioma masquerading as interstitial lung disease: a distinctive variant of mesothelioma. (23797722)
2013
5
Legal claims for malignant mesothelioma: dealing with all cases. (23415607)
2013
6
Treatment and survival analyses of malignant mesothelioma in Japan. (22928694)
2013
7
Pleuroscopic punch biopsy using insulated-tip diathermic knife-2 for the diagnosis of desmoplastic malignant mesothelioma. (24162121)
2013
8
18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography fused imaging in malignant mesothelioma patients: looking from outside is not enough. (23206832)
2013
9
Estrogen receptor I^ activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo. (24061575)
2013
10
Malignant mesothelioma: new insights into a rare disease. (23276688)
2013
11
Does CA125 binding to mesothelin impact the detection of malignant mesothelioma? (23357461)
2013
12
Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis. (22208496)
2012
13
The ticking time-bomb of asbestos: its insidious role in the development of malignant mesothelioma. (22459593)
2012
14
Adiponectin pathway attenuates malignant mesothelioma cell growth. (22095628)
2012
15
Plasma versus serum levels of osteopontin and mesothelin in patients with malignant mesothelioma--which is best? (21397972)
2011
16
miR-34a expression, cell cycle arrest and cell death of malignant mesothelioma cells upon treatment with radiation, docetaxel or combination treatment. (22237142)
2011
17
EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene. (21869823)
2011
18
Association of malignant mesothelioma and asbestos related conditions with ovarian cancer: shared biomarkers and a possible etiological link? (21158701)
2011
19
LATS2 is a tumor suppressor gene of malignant mesothelioma. (21245096)
2011
20
Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma. (21281820)
2011
21
Biomarkers in malignant mesothelioma: diagnostic and prognostic role of soluble mesothelin-related peptide. (21928246)
2011
22
Oral presentation of malignant mesothelioma. (20813558)
2011
23
Characterization of side population cells in human malignant mesothelioma cell lines. (20493579)
2010
24
Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. (20573372)
2010
25
Pleural malignant mesothelioma with osteoclast-like giant cells. (20403048)
2010
26
Pemetrexed in the treatment of malignant mesothelioma: results from an expanded access program in Germany. (19818589)
2010
27
Tenascin-X is a novel diagnostic marker of malignant mesothelioma. (19738457)
2009
28
Lymphangiomatoid pattern in diffuse malignant mesothelioma of the pleura: a report of six cases. (19618209)
2009
29
Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group. (19653732)
2009
30
Prolonged survival due to spontaneous regression and surgical excision of malignant mesothelioma. (17184695)
2007
31
Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. (17192790)
2007
32
Malignant mesothelioma: global incidence and relationship with asbestos. (17634686)
2007
33
Malignant mesothelioma following thoracic radiotherapy for lung cancer. (17475364)
2007
34
Staging in malignant mesothelioma. (17126172)
2006
35
Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling. (16007577)
2005
36
Malignant mesothelioma of the spermatic cord: case report and review of the literature. (17629883)
2005
37
Reduced Fhit protein expression in human malignant mesothelioma. (14569398)
2004
38
Inhibition of proliferation, migration, and matrix metalloprotease production in malignant mesothelioma cells by tyrosine kinase inhibitors. (15720796)
2004
39
Assessment of cell cycle state may facilitate the histopathological diagnosis of malignant mesothelioma. (12713628)
2003
40
Quinidine impairs proliferation of neurofibromatosis type 2-deficient human malignant mesothelioma cells. (12673723)
2003
41
Gene expression profiling of malignant mesothelioma. (12912960)
2003
42
Transforming growth factor-beta released by PPD-presenting malignant mesothelioma cells inhibits interferon-gamma synthesis by an anti-PPD CD4+ T-cell clone. (12525871)
2003
43
Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura. (12771921)
2003
44
Expression and prognostic significance of catalase in malignant mesothelioma. (11283936)
2001
45
The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma. (11697834)
2001
46
Localized malignant mesothelioma of the pleura. (11564223)
2001
47
Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma. (11479207)
2001
48
The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma. (9466670)
1998
49
Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma. (9139887)
1997
50
p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. (7923195)
1994

Variations for Malignant Mesothelioma

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Expression for genes affiliated with Malignant Mesothelioma

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Expression patterns in normal tissues for genes affiliated with Malignant Mesothelioma

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Pathways for genes affiliated with Malignant Mesothelioma

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Pathways related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CTNNA1, CDH2
2
Show member pathways
9.7CTNNA1, CDH2
39.7CTNNA1, CDH2
49.4SPP1, MET, CDH2
59.4CTNNA1, CDH2, MUC1
69.3CTNNA1, CDH2, MET
7
Show member pathways
8.7SPP1, MUC1, MET, CDH2, CTNNA1

Compounds for genes affiliated with Malignant Mesothelioma

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Compounds related to Malignant Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1indium449.9MUC1, CEACAM3
2polyethylene glycol449.6SPP1, THBD, MUC1
3cyanine449.6CALB2, CEACAM3
4chloramphenicol44 2 50 1112.6MUC1, SFTPB, THBD, WT1
5curcumin449.5SPP1, THBD, WT1, SOD2
6calcitriol44 61 24 1112.5SOD2, THBD, WT1, SPP1
7pdtc449.4MET, SOD2, SFTPB
8agar449.3SPP1, SOD2, MUC1, MET
9matrigel449.3SPP1, THBD, CDH2, MET, MUC1
10ascorbic acid44 2410.3SPP1, SOD2, SFTPB, THBD
11adriamycin449.3MUC1, MET, SOD2, CEACAM3
12mucicarmine449.3CALB2, NKX2-1, MUC1, CEACAM3
13vitamin d449.2SPP1, WT1, MET, SOD2, THBD
14glycogen44 2410.2CTNNA1, CDH2, MET, MUC1, THBD
15bleomycin44 1110.1SOD2, SFTPB, SPP1
16ribonucleic acid449.1SPP1, SFTPB, MUC1, MET, NKX2-1, WT1
17cycloheximide449.0MET, SOD2, SFTPB, SPP1, THBD
18threonine449.0SPP1, SFTPB, WT1, NKX2-1, MET, MUC1
19butyrate449.0SOD2, SPP1, MUC1, CALB2, WT1
20actinomycin d449.0THBD, SPP1, MUC1, SOD2, MET, SFTPB
21fibrinogen449.0SFTPB, SPP1, THBD, CEACAM3
22gold448.9PDPN, CEACAM3, SFTPB, MUC1
23sialic acid448.9PDPN, CDH2, CEACAM3, MUC1
24polysaccharide448.9PDPN, CDH2, THBD, MUC1
25arginine448.8MET, WT1, SFTPB, SPP1, THBD, SOD2
2612-o-tetradecanoylphorbol 13-acetate448.8MUC1, MET, SOD2, WT1, CTNNA1, SFTPB
27creatinine448.8THBD, WT1, CEACAM3, MUC1, SPP1, SOD2
28cholesterol44 28 24 1111.8SFTPB, SPP1, THBD, CEACAM3, MUC1, MET
29dexamethasone44 50 28 1111.7SOD2, SFTPB, NKX2-1, CDH2, THBD, SPP1
30atp44 289.7THBD, SFTPB, MET, CDH2, SOD2, SPP1
31hyaluronic acid44 249.7THBD, MUC1, MSLN, SPP1, CALB2, WT1
32glucose448.6SPP1, THBD, CDH2, MUC1, CEACAM3, MET
33oxygen44 249.6MUC1, CEACAM3, SFTPB, MET, SOD2, SPP1
34lipid448.6CDH2, MET, MUC1, SFTPB, THBD, SPP1
35thymidine44 249.5SFTPB, MET, WT1, MUC1, CEACAM3, CALB2
36steroid448.5NKX2-1, WT1, CALB2, MET, CEACAM3, THBD
37retinoic acid44 249.5CDH2, NKX2-1, MET, MUC1, SFTPB, WT1
38serine448.5THBD, MUC1, MET, WT1, SPP1, SFTPB
39hematoxylin448.4PDPN, MUC1, CALB2, CEACAM3, NKX2-1
40cysteine448.3SPP1, CDH2, SFTPB, WT1, MET, MUC1
41testosterone44 61 24 1111.3WT1, CDH2, CALB2, MET, MUC1, SOD2
42oligonucleotide448.1SPP1, CTNNA1, WT1, THBD, MSLN, MET
43nitric oxide44 24 119.9SOD2, SFTPB, THBD, MUC1, CEACAM3, MET
44progesterone44 28 61 24 1111.6MUC1, WT1, CDH2, CALB2, MET, CEACAM3
45calcium44 50 24 1110.6MUC1, SPP1, SFTPB, CEACAM3, MET, CALB2
46estrogen447.2THBD, MSLN, MET, CALB2, NKX2-1, CDH2
47b 723447.0WT1, THBD, MUC1, CALB2, CDH2, PDPN
48vegf446.1SPP1, MET, PDPN, CDH2, WT1, CTNNA1
49paraffin445.7CALB2, MET, CEACAM3, MUC1, SOD2, SFTPB
50tyrosine445.7WT1, THBD, SFTPB, SPP1, CTNNA1, CDH2

GO Terms for genes affiliated with Malignant Mesothelioma

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Cellular components related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.7CTNNA1, CDH2
2intercalated discGO:0147049.4CDH2, CTNNA1
3apical plasma membraneGO:0163249.1CDH2, PDPN, MUC1
4lamellipodiumGO:0300278.8CTNNA1, CDH2, PDPN

Biological processes related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adherens junction organizationGO:0343329.7CTNNA1, CDH2
2positive regulation of muscle cell differentiationGO:0511499.6CDH2, CTNNA1
3muscle cell differentiationGO:0426929.4CTNNA1, CDH2
4response to hyperoxiaGO:0550939.3PDPN, SOD2
5cell adhesionGO:0071558.8CTNNA1, CDH2, MSLN, SPP1

Molecular functions related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:0452959.4CDH2, CTNNA1
2protein bindingGO:0055157.5THBD, MUC1, MSLN, MET, NKX2-1, BAP1

Products for genes affiliated with Malignant Mesothelioma

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Sources for Malignant Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet