MCID: MLG075
MIFTS: 68

Malignant Mesothelioma malady

Rare diseases, Cancer diseases, Respiratory diseases categories

Summaries for Malignant Mesothelioma

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MedlinePlus:33 The tissue that lines your lungs, stomach, heart, and other organs is called mesothelium. mesothelioma is a tumor of that tissue. it usually starts in the lungs, but can also start in the abdomen or other organs. it can be benign (not cancer) or malignant (cancer.) malignant mesothelioma is a rare but serious type of cancer. most people who get it have worked on jobs where they inhaled asbestos particles. after being exposed to asbestos, it usually takes a long time for the disease to form. symptoms include trouble breathing pain under the rib cage pain, swelling, or lumps in the abdomen weight loss for no known reason sometimes it is hard to tell the difference between malignant mesothelioma and lung cancer. your doctor uses imaging tests and a biopsy to make the diagnosis. malignant mesothelioma is often found when it is advanced. this makes it harder to treat. treatment may include surgery, radiation, and/or chemotherapy. nih: national cancer institute

MalaCards based summary: Malignant Mesothelioma, also known as mesothelioma, is related to malignant pleural mesothelioma and adenomatoid tumor. An important gene associated with Malignant Mesothelioma is MMS (Malignant mesothelioma, susceptibility to), and among its related pathways are Cell adhesion Endothelial cell contacts by junctional mechanisms and N-cadherin signaling events. The compounds indium and polyethylene glycol have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testis, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Disease Ontology:9 A cell type cancer that has material basis in mesothelial tissue.

Wikipedia:64 Mesothelioma (or, more precisely, malignant mesothelioma) is a rare form of cancer that develops from... more...

Description from OMIM:46 156240

Aliases & Classifications for Malignant Mesothelioma

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Sources:
9Disease Ontology, 10diseasecard, 42NIH Rare Diseases, 23GTR, 46OMIM, 11DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 61UMLS, 28ICD9CM, 39NCIt, 34MeSH, 56SNOMED-CT, 35MESH via Orphanet, 27ICD10 via Orphanet, 62UMLS via Orphanet, 26ICD10
See all sources

Malignant Mesothelioma, Aliases & Descriptions:

Name: Malignant Mesothelioma 9 42 46 11 44 61
Mesothelioma 48 33 61
Asbestos-Related Malignant Mesothelioma 9 61
Advanced Malignant Mesothelioma 9 61
Malignant Tumor of Mesothelium 9 61
 
Mesothelioma, Malignant 42 23
Malignant Mesothelioma, Susceptibility to 10
Mesothelioma Diffuse Malignant 44
Diffuse Malignant Mesothelioma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
mesothelioma:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology9 DOID:1790
ICD9CM28 163
NCIt39 C7865
OMIM46 156240
MeSH34 D008654
SNOMED-CT56 62064005
MESH via Orphanet35 D008654
ICD10 via Orphanet27 C45
UMLS via Orphanet62 C0025500
ICD1026 C45, C45.9

Related Diseases for Malignant Mesothelioma

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Diseases in the Malignant Mesothelioma family:

Benign Intermediate Mesothelioma Benign Mesothelioma

Diseases related to Malignant Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 230)
idRelated DiseaseScoreTop Affiliating Genes
1malignant pleural mesothelioma31.1MSLN, CALB2
2adenomatoid tumor31.1WT1, CALB2
3papillary adenocarcinoma30.9MUC1, NKX2-1
4malignant peritoneal mesothelioma30.8CALB2
5wilms tumor30.7CALB2, NKX2-1, PDPN, WT1
6synovial sarcoma30.7CALB2, MET, MUC1
7cystadenocarcinoma30.7CEACAM3, MUC1
8lung cancer30.6MUC1, MET, NKX2-1
9interstitial lung disease30.5NKX2-1, SFTPB
10angiosarcoma30.4MUC1, CALB2, PDPN
11pulmonary alveolar proteinosis30.4CEACAM3, MUC1, SFTPB
12epithelioid sarcoma30.4MUC1, CALB2
13benign mesothelioma30.4WT1, PDPN, NKX2-1, CALB2, MSLN, THBD
14malignant peripheral nerve sheath tumor30.3MUC1, MET
15mucinous cystadenocarcinoma30.3CEACAM3, MUC1
16non-small cell lung carcinoma30.2SFTPB, MET, NKX2-1
17hemangioma30.1SFTPB, NKX2-1, PDPN
18sarcoma30.0WT1, CALB2, MET, MUC1, SOD2
19papillary thyroid carcinoma30.0MET, SPP1
20endometrial carcinoma29.9CALB2, NKX2-1, CDH2
21thymoma29.8CTNNA1, NKX2-1, CALB2, CEACAM3
22colorectal cancer29.6MUC1, CEACAM3, MET, PDPN, CTNNA1
23chondrosarcoma29.6MUC1, CEACAM3, MET, CTNNA1
24ovarian cancer29.5SPP1, MUC1, CEACAM3, MSLN, MET, CALB2
25papillary carcinoma29.3SOD2, MUC1, CEACAM3, MET, CALB2, NKX2-1
26glioblastoma28.9SOD2, MET, PDPN, CDH2, CTNNA1
27astrocytoma28.9CTNNA1, CDH2, MET, SOD2, SPP1
28melanoma28.7SPP1, SOD2, CEACAM3, MET, CALB2, NKX2-1
29stomach cancer28.6SPP1, SOD2, CEACAM3, MET, PDPN, CDH2
30adenocarcinoma28.4CDH2, PDPN, NKX2-1, CALB2, MET, MSLN
31breast cancer28.2SPP1, SOD2, MUC1, CEACAM3, MSLN, MET
32lung adenocarcinoma28.2SFTPB, THBD, SPP1, SOD2, MUC1, CTNNA1
33benign multicystic peritoneal mesothelioma10.6
34peritonitis10.6
35sclerosing hemangioma10.5SFTPB
36metanephric adenoma10.5WT1
37peritoneal cystic mesothelioma10.5
38osteofibrous dysplasia10.4SPP1
39benign fibrous mesothelioma10.4
40leukemia10.4
41sertoli cell tumor10.4MUC1, CALB2
42desmoplastic small round cell tumor10.4MUC1, WT1
43peritoneal mesothelioma10.4
44endotheliitis10.4
45merkel cell carcinoma10.4MUC1, NKX2-1
46ovarian brenner tumor10.4WT1, THBD
47congenital diaphragmatic hernia10.4SFTPB
48cutaneous paget's disease10.4MUC1, CEACAM3
49adenosquamous carcinoma10.4MUC1, NKX2-1
50syringoma10.4MUC1, CEACAM3

Graphical network of the top 20 diseases related to Malignant Mesothelioma:



Diseases related to malignant mesothelioma

Symptoms for Malignant Mesothelioma

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Clinical features from OMIM:

156240

Drugs & Therapeutics for Malignant Mesothelioma

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Drug clinical trials:

Search ClinicalTrials for Malignant Mesothelioma

Search NIH Clinical Center for Malignant Mesothelioma

Genetic Tests for Malignant Mesothelioma

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Genetic tests related to Malignant Mesothelioma:

id Genetic test Affiliating Genes
1 Mesothelioma, Malignant23

Anatomical Context for Malignant Mesothelioma

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MalaCards organs/tissues related to Malignant Mesothelioma:

32
Lung, Heart, Testis, Testes, Breast, Endothelial, T cells, Bone, Neutrophil, Lymph node, Brain, Colon, Liver, Pancreas, Thyroid, Skin, Kidney, Placenta, Monocytes, B cells, Appendix

Animal Models for Malignant Mesothelioma or affiliated genes

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Publications for Malignant Mesothelioma

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Articles related to Malignant Mesothelioma:

(show top 50)    (show all 719)
idTitleAuthorsYear
1
Overview of the biochemical and genetic processes in malignant mesothelioma. (25210967)
2014
2
CREB-induced inflammation is important for malignant mesothelioma growth. (25111229)
2014
3
Low PIAS3 Expression in Malignant Mesothelioma Is Associated with Increased STAT3 Activation and Poor Patient Survival. (25124686)
2014
4
Diffuse intrapulmonary malignant mesothelioma masquerading as interstitial lung disease: a distinctive variant of mesothelioma. (23797722)
2013
5
Legal claims for malignant mesothelioma: dealing with all cases. (23415607)
2013
6
Treatment and survival analyses of malignant mesothelioma in Japan. (22928694)
2013
7
Pleuroscopic punch biopsy using insulated-tip diathermic knife-2 for the diagnosis of desmoplastic malignant mesothelioma. (24162121)
2013
8
18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography fused imaging in malignant mesothelioma patients: looking from outside is not enough. (23206832)
2013
9
Estrogen receptor I^ activation impairs mitochondrial oxidative metabolism and affects malignant mesothelioma cell growth in vitro and in vivo. (24061575)
2013
10
Malignant mesothelioma: new insights into a rare disease. (23276688)
2013
11
Does CA125 binding to mesothelin impact the detection of malignant mesothelioma? (23357461)
2013
12
Malignant mesothelioma of the tunica vaginalis testis: diagnostic studies and differential diagnosis. (22208496)
2012
13
The ticking time-bomb of asbestos: its insidious role in the development of malignant mesothelioma. (22459593)
2012
14
Adiponectin pathway attenuates malignant mesothelioma cell growth. (22095628)
2012
15
Plasma versus serum levels of osteopontin and mesothelin in patients with malignant mesothelioma--which is best? (21397972)
2011
16
miR-34a expression, cell cycle arrest and cell death of malignant mesothelioma cells upon treatment with radiation, docetaxel or combination treatment. (22237142)
2011
17
EphrinA1 inhibits malignant mesothelioma tumor growth via let-7 microRNA-mediated repression of the RAS oncogene. (21869823)
2011
18
Association of malignant mesothelioma and asbestos related conditions with ovarian cancer: shared biomarkers and a possible etiological link? (21158701)
2011
19
LATS2 is a tumor suppressor gene of malignant mesothelioma. (21245096)
2011
20
Syntenic relationships between genomic profiles of fiber-induced murine and human malignant mesothelioma. (21281820)
2011
21
Biomarkers in malignant mesothelioma: diagnostic and prognostic role of soluble mesothelin-related peptide. (21928246)
2011
22
Oral presentation of malignant mesothelioma. (20813558)
2011
23
Characterization of side population cells in human malignant mesothelioma cell lines. (20493579)
2010
24
Mesothelin (MSLN) promoter is hypomethylated in malignant mesothelioma, but its expression is not associated with methylation status of the promoter. (20573372)
2010
25
Pleural malignant mesothelioma with osteoclast-like giant cells. (20403048)
2010
26
Pemetrexed in the treatment of malignant mesothelioma: results from an expanded access program in Germany. (19818589)
2010
27
Tenascin-X is a novel diagnostic marker of malignant mesothelioma. (19738457)
2009
28
Lymphangiomatoid pattern in diffuse malignant mesothelioma of the pleura: a report of six cases. (19618209)
2009
29
Guidelines for pathologic diagnosis of malignant mesothelioma: a consensus statement from the International Mesothelioma Interest Group. (19653732)
2009
30
Prolonged survival due to spontaneous regression and surgical excision of malignant mesothelioma. (17184695)
2007
31
Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma. (17192790)
2007
32
Malignant mesothelioma: global incidence and relationship with asbestos. (17634686)
2007
33
Malignant mesothelioma following thoracic radiotherapy for lung cancer. (17475364)
2007
34
Staging in malignant mesothelioma. (17126172)
2006
35
Molecular characterization of tumour heterogeneity and malignant mesothelioma cell differentiation by gene profiling. (16007577)
2005
36
Malignant mesothelioma of the spermatic cord: case report and review of the literature. (17629883)
2005
37
Reduced Fhit protein expression in human malignant mesothelioma. (14569398)
2004
38
Inhibition of proliferation, migration, and matrix metalloprotease production in malignant mesothelioma cells by tyrosine kinase inhibitors. (15720796)
2004
39
Assessment of cell cycle state may facilitate the histopathological diagnosis of malignant mesothelioma. (12713628)
2003
40
Quinidine impairs proliferation of neurofibromatosis type 2-deficient human malignant mesothelioma cells. (12673723)
2003
41
Gene expression profiling of malignant mesothelioma. (12912960)
2003
42
Transforming growth factor-beta released by PPD-presenting malignant mesothelioma cells inhibits interferon-gamma synthesis by an anti-PPD CD4+ T-cell clone. (12525871)
2003
43
Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura. (12771921)
2003
44
Expression and prognostic significance of catalase in malignant mesothelioma. (11283936)
2001
45
The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma. (11697834)
2001
46
Localized malignant mesothelioma of the pleura. (11564223)
2001
47
Aberrant methylation and simian virus 40 tag sequences in malignant mesothelioma. (11479207)
2001
48
The gene for the cyclin-dependent-kinase-4 inhibitor, CDKN2A, is preferentially deleted in malignant mesothelioma. (9466670)
1998
49
Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma. (9139887)
1997
50
p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma. (7923195)
1994

Variations for Malignant Mesothelioma

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Expression for genes affiliated with Malignant Mesothelioma

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Expression patterns in normal tissues for genes affiliated with Malignant Mesothelioma

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Pathways for genes affiliated with Malignant Mesothelioma

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Pathways related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CDH2, CTNNA1
29.7CTNNA1, CDH2
3
Show member pathways
9.7CTNNA1, CDH2
49.4MET, CDH2, SPP1
59.4CTNNA1, CDH2, MUC1
69.3CTNNA1, MET, CDH2
7
Show member pathways
8.7CTNNA1, CDH2, SPP1, MUC1, MET

Compounds for genes affiliated with Malignant Mesothelioma

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Compounds related to Malignant Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 76)
idCompoundScoreTop Affiliating Genes
1indium449.9CEACAM3, MUC1
2polyethylene glycol449.6MUC1, THBD, SPP1
3cyanine449.6CALB2, CEACAM3
4chloramphenicol44 3 50 1212.6THBD, SFTPB, MUC1, WT1
5curcumin449.5SPP1, THBD, SOD2, WT1
6calcitriol44 60 25 1212.5SPP1, THBD, SOD2, WT1
7pdtc449.4MET, SOD2, SFTPB
8agar449.3SPP1, SOD2, MUC1, MET
9matrigel449.3SPP1, THBD, MUC1, MET, CDH2
10ascorbic acid44 2510.3SPP1, THBD, SFTPB, SOD2
11adriamycin449.3SOD2, MUC1, CEACAM3, MET
12mucicarmine449.3MUC1, CEACAM3, CALB2, NKX2-1
13vitamin d449.2SPP1, THBD, SOD2, MET, WT1
14glycogen44 2510.2THBD, MUC1, MET, CDH2, CTNNA1
15bleomycin44 1210.1SOD2, SFTPB, SPP1
16ribonucleic acid449.1SPP1, SFTPB, MUC1, MET, NKX2-1, WT1
17cycloheximide449.0SPP1, THBD, SFTPB, SOD2, MET
18threonine449.0SPP1, SFTPB, MUC1, MET, NKX2-1, WT1
19butyrate449.0SPP1, SOD2, MUC1, CALB2, WT1
20actinomycin d449.0SPP1, THBD, SFTPB, SOD2, MUC1, MET
21fibrinogen449.0SPP1, THBD, SFTPB, CEACAM3
22gold448.9PDPN, CEACAM3, MUC1, SFTPB
23sialic acid448.9MUC1, CEACAM3, PDPN, CDH2
24polysaccharide448.9THBD, MUC1, PDPN, CDH2
25arginine448.8SPP1, THBD, SFTPB, SOD2, MET, WT1
2612-o-tetradecanoylphorbol 13-acetate448.8SFTPB, SOD2, MUC1, MET, WT1, CTNNA1
27creatinine448.8SPP1, THBD, SOD2, MUC1, CEACAM3, WT1
28cholesterol44 29 25 1211.8SPP1, THBD, SFTPB, MUC1, CEACAM3, MET
29dexamethasone44 50 29 1211.7SPP1, THBD, SFTPB, SOD2, MUC1, NKX2-1
30atp44 299.7SPP1, THBD, SFTPB, SOD2, MET, CDH2
31hyaluronic acid44 259.7SPP1, THBD, MUC1, MSLN, CALB2, WT1
32glucose448.6SPP1, THBD, MUC1, CEACAM3, MET, CDH2
33oxygen44 259.6SPP1, SFTPB, SOD2, MUC1, CEACAM3, MET
34lipid448.6SPP1, THBD, SFTPB, SOD2, MUC1, MET
35thymidine44 259.5SFTPB, MUC1, CEACAM3, MET, CALB2, WT1
36steroid448.5THBD, CEACAM3, MET, CALB2, NKX2-1, WT1
37retinoic acid44 259.5SPP1, THBD, SFTPB, MUC1, MET, NKX2-1
38serine448.5SPP1, THBD, SFTPB, MUC1, MET, NKX2-1
39hematoxylin448.4MUC1, CEACAM3, CALB2, NKX2-1, PDPN
40cysteine448.3SPP1, THBD, SFTPB, SOD2, MUC1, MET
41testosterone44 60 25 1211.3SPP1, SOD2, MUC1, MET, CALB2, CDH2
42oligonucleotide448.1SPP1, THBD, MSLN, MET, NKX2-1, CDH2
43nitric oxide44 25 129.9THBD, SFTPB, SOD2, MUC1, CEACAM3, MET
44progesterone44 29 60 25 1211.6SPP1, THBD, SFTPB, MUC1, CEACAM3, MET
45calcium44 50 25 1210.6SPP1, SFTPB, MUC1, CEACAM3, MET, CALB2
46estrogen447.2SPP1, THBD, MUC1, CEACAM3, MSLN, MET
47b 723447.0WT1, CDH2, PDPN, NKX2-1, CALB2, MSLN
48vegf446.1CEACAM3, MUC1, SOD2, SFTPB, THBD, SPP1
49paraffin445.7CTNNA1, WT1, CDH2, PDPN, NKX2-1, CALB2
50tyrosine445.7SPP1, THBD, SFTPB, SOD2, MUC1, CEACAM3

GO Terms for genes affiliated with Malignant Mesothelioma

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Cellular components related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.7CTNNA1, CDH2
2intercalated discGO:0147049.4CDH2, CTNNA1
3apical plasma membraneGO:0163249.1CDH2, PDPN, MUC1
4lamellipodiumGO:0300278.8CTNNA1, CDH2, PDPN

Biological processes related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adherens junction organizationGO:0343329.7CTNNA1, CDH2
2positive regulation of muscle cell differentiationGO:0511499.6CTNNA1, CDH2
3muscle cell differentiationGO:0426929.4CDH2, CTNNA1
4response to hyperoxiaGO:0550939.3SOD2, PDPN
5cell adhesionGO:0071558.8CTNNA1, SPP1, MSLN, CDH2

Molecular functions related to Malignant Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1gamma-catenin bindingGO:0452959.4CDH2, CTNNA1
2protein bindingGO:0055157.5THBD, MUC1, MSLN, MET, NKX2-1, BAP1

Products for genes affiliated with Malignant Mesothelioma

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Sources for Malignant Mesothelioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet