MMMT
MCID: MLG098
MIFTS: 45

Malignant Mixed Mullerian Tumor (MMMT) malady

Rare diseases, Cancer diseases categories
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Summaries for Malignant Mixed Mullerian Tumor

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NIH Rare Diseases:42 A malignant mixed müllerian tumor (mmmt), also called a carcinosarcoma, is a type of cancer that contains two types of cells, known as the adenocarcinoma and sarcoma types. these tumors usually develop in tissues of the female genital tract and are associated with a poor outcome. the majority of these tumors arise in the uterus, though they can also occur in the ovaries, fallopian tubes, and cervix. very rarely, mmmts can develop in the female peritoneum (lining of the abdominal wall). last updated: 12/6/2011

MalaCards based summary: Malignant Mixed Mullerian Tumor, also known as carcinosarcoma, is related to leiomyosarcoma and basal cell carcinoma. An important gene associated with Malignant Mixed Mullerian Tumor is AFP (alpha-fetoprotein), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Glucocorticoid receptor regulatory network. The compounds 2-acetylaminofluorene and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and cervix, and related mouse phenotypes are tumorigenesis and reproductive system.

Aliases & Classifications for Malignant Mixed Mullerian Tumor

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Sources:
42NIH Rare Diseases, 10DISEASES, 44Novoseek, 62UMLS
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Malignant Mixed Mullerian Tumor, Aliases & Descriptions:

Name: Malignant Mixed Mullerian Tumor 42
Carcinosarcoma 42 10 44 62
Mixed Tumor, Mullerian 42 62
Malignant Mixed Mesodermal Tumor 62
 
Mixed Mullerian Tumor 42
Mixed Tumor Mullerian 44
Mmmt 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Malignant Mixed Mullerian Tumor

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Diseases related to Malignant Mixed Mullerian Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma30.8TP53, VIM
2basal cell carcinoma30.6TP53, KRT7
3papilloma30.5TP53, CDKN2A
4rhabdomyosarcoma30.4VIM, TP53
5teratoma30.4KRT7, AFP
6breast cancer30.3KRT7, VIM, TP53
7endometrial carcinoma30.3TP53, CDKN2A, KRT7
8lung cancer30.3TP53, CDKN2A, KRT7
9tubular adenocarcinoma30.2KRT7, AFP
10adenoma30.1CDKN2A, KRT7, TP53
11chordoma30.1KRT7, VIM
12liposarcoma30.1VIM, TP53
13wilms tumor29.8KRT7, VIM
14adenocarcinoma29.8TP53, AFP, CDKN2A, VIM, KRT7
15colorectal cancer29.5TP53, KRT7, CDKN2A
16melanoma29.2TP53, VIM, CDKN2A
17uterine carcinosarcoma10.9
18ovarian carcinosarcoma10.6
19sarcoma10.5
20pseudomyxoma peritonei10.5KRT7
21metanephric adenoma10.5KRT7
22liver sarcoma10.5AFP
23peritonitis10.4
24actinic keratosis10.4TP53
25choroid plexus papilloma10.4TP53
26meningioma10.4VIM
27sertoli cell tumor10.4VIM
28adenomatoid tumor10.4VIM
29esophagitis10.3
30uterine sarcoma10.3
31myasthenia gravis10.3
32papillary serous adenocarcinoma10.3
33endocervicitis10.3
34bilateral breast cancer10.3
35cervical carcinosarcoma10.3
36cervicitis10.3
37endometriosis10.3
38fallopian tube carcinosarcoma10.3
39leiomyoma10.3
40nephrotic syndrome10.3
41pancreatitis10.3
42vaginal carcinosarcoma10.3
43superior vena cava syndrome10.3
44blastoma10.3
45bladder diverticulum10.3
46kidney cancer10.3TP53, KRT7
47acinar cell carcinoma10.3AFP, KRT7
48sertoli-leydig cell tumor10.2AFP, KRT7
49pleomorphic adenoma10.2
50spindle cell carcinoma10.2

Graphical network of the top 20 diseases related to Malignant Mixed Mullerian Tumor:



Diseases related to malignant mixed mullerian tumor

Symptoms for Malignant Mixed Mullerian Tumor

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Drugs & Therapeutics for Malignant Mixed Mullerian Tumor

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Drug clinical trials:

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Search NIH Clinical Center for Malignant Mixed Mullerian Tumor

Genetic Tests for Malignant Mixed Mullerian Tumor

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Anatomical Context for Malignant Mixed Mullerian Tumor

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MalaCards organs/tissues related to Malignant Mixed Mullerian Tumor:

32
Ovary, Uterus, Cervix, Lung, Breast

Animal Models for Malignant Mixed Mullerian Tumor or affiliated genes

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MGI Mouse Phenotypes related to Malignant Mixed Mullerian Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3CDKN2A, TP53, AFP
2MP:00053898.1CDKN2A, VIM, TP53, AFP
3MP:00053848.0CDKN2A, KRT7, VIM, TP53
4MP:00053868.0AFP, TP53, VIM, CDKN2A

Publications for Malignant Mixed Mullerian Tumor

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Articles related to Malignant Mixed Mullerian Tumor:

(show all 48)
idTitleAuthorsYear
1
Endometrioid carcinoma infiltrating atypical leiomyoma: a mimicker of malignant mixed Mullerian tumor. (24943777)
2014
2
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in a rare case of recurrent malignant mixed mullerian tumor. (25191116)
2014
3
Malignant mixed mullerian tumor of the ovary. (25404814)
2014
4
ANNA-1 (anti-Hu) associated sensory neuronopathy with malignant mixed mullerian tumor. (23536385)
2013
5
Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report. (24293882)
2012
6
Malignant mixed mullerian tumor: an immunohistochemical study. (22848863)
2012
7
Malignant mixed Mullerian tumor of the ovary with two cases and review of the literature. (21298439)
2011
8
Uncommon manifestations of Endocervical Malignant Mixed Mullerian Tumor with Incidental Bilateral Fallopian Tube Carcinoma. (21701666)
2011
9
Malignant mixed Mullerian tumor of broad ligament with synchronous ovarian and endometrial carcinoma: a rare association. (21546752)
2011
10
Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review. (20882897)
2010
11
Comparative analysis of P16 and P53 expression in uterine malignant mixed mullerian tumors. (19851197)
2009
12
Intracardiac metastasis of a Malignant Mixed Mullerian tumor (MMMT): progressive dyspnoea due to obstruction of the left atrium and the left ventricle without left ventricular dysfunction or primary lung disease. (19652943)
2009
13
Homologous type of malignant mixed Mullerian tumor of the uterus presenting as a cervical mass. (19837648)
2009
14
Biopsy-proven cerebellar metastasis from a malignant mixed mullerian tumor (MMMT) of the uterus: case report. (19480254)
2009
15
Bilateral ovarian malignant mixed Mullerian tumor in a dog. (19176505)
2009
16
Extra genital heterologous malignant mixed mullerian tumor of primary peritoneal origin. (19136793)
2009
17
CT imaging of a primary malignant mixed mullerian tumor arising from the peritoneum. (18760728)
2008
18
Malignant mixed mullerian tumor of the urinary bladder in a 73 year old woman. (18559304)
2008
19
Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI. (18562759)
2008
20
Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus. (17640554)
2007
21
Malignant mixed mullerian tumor in a rabbit (Oryctolagus cuniculus): case report with immunohistochemistry. (16847001)
2006
22
Diagnostic dilemma in a case of malignant mixed mullerian tumor of the cervix. (16813659)
2006
23
Primary malignant mixed Mullerian tumor arising in the rectosigmoid. (16612719)
2006
24
Paraneoplastic subacute sensory neuronopathy secondary to a malignant mixed mullerian tumor. (16449165)
2006
25
Pancreatic metastasis of an ovarian malignant mixed Mullerian tumor identified by EUS-guided fine needle aspiration and Trucut needle biopsy. (16407622)
2006
26
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene. (15863610)
2005
27
Presentation with superior vena cava syndrome secondary to solitary lung metastasis mimicking primary lung cancer following resection of a uterine malignant mixed mullerian tumor: brief case report. (15653218)
2005
28
Primary peritoneal carcinosarcoma (malignant mixed mullerian tumor): Report of a case with five-year disease free survival after surgery and chemoradiation and a review of literature. (16227168)
2005
29
Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma. (15790462)
2005
30
Primary malignant mixed mullerian tumor of the vagina immunohistochemically confirmed. (14735374)
2005
31
Malignant mixed mullerian tumor (MMMT) of the cervix. (15863143)
2005
32
Comment on "Malignant mixed Mullerian tumor of the ovary: an argument for BRCA3 or a coincidental cluster of unconnected cancer". (15582005)
2004
33
Malignant mixed Mullerian tumor of the ovary growing into an inguinal hernia sac: report of a case. (14513334)
2003
34
Malignant mixed mullerian tumor of the ovary and bilateral breast cancer: an argument for BRCA3, or a coincidental cluster of unconnected cancers? (14599878)
2003
35
Malignant mixed Mullerian tumor of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma component. (14599882)
2003
36
Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation. (11975686)
2002
37
Malignant mixed mullerian tumor of the ovary: report of four cases. (11321500)
2001
38
Good response of malignant mixed mullerian tumor of the ovary to paclitaxel and cisplatin chemotherapy. (10609493)
1999
39
Myasthenia gravis associated with malignant mixed Mullerian tumor of the uterus. (9062162)
1997
40
Malignant Mixed Mullerian Tumor of the Extra-genital Coelomic Epithelium: Report of Two Cases. (11173640)
1997
41
Malignant mixed mullerian tumor of the female peritoneum: treatment and outcome of three cases. (9190987)
1997
42
Extragenital malignant mixed mullerian tumor. (8386082)
1993
43
Complex karyotypic aberrations, including i(12p), in malignant mixed mullerian tumor of uterus. (1317254)
1992
44
Malignant mixed mullerian tumor arising in extragenital endometriosis: report of a case and review of the literature. (3002920)
1986
45
Malignant mixed Mullerian tumor of the fallopian tube. Report of a case and review of literature. (6247252)
1980
46
Malignant mixed mullerian tumor of the cervix following cyclophosphamide therapy for nephrotic syndrome. (4346219)
1973
47
CYTOLOGIC FINDINGS ASSOCIATED WITH PRIMARY UTERINE MALIGNANCIES OF MIXED CELL TYPES (MALIGNANT MIXED MULLERIAN TUMOR). (14192726)
1964
48
Malignant mixed mullerian tumor. (13182583)
1954

Variations for Malignant Mixed Mullerian Tumor

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Expression for genes affiliated with Malignant Mixed Mullerian Tumor

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Expression patterns in normal tissues for genes affiliated with Malignant Mixed Mullerian Tumor

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Pathways for genes affiliated with Malignant Mixed Mullerian Tumor

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Pathways related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4KRT7, VIM
29.2AFP, TP53
39.2TP53, AFP
49.1TP53, VIM
5
Show member pathways
9.0CDKN2A, TP53
69.0CDKN2A, TP53
7
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.0CDKN2A, TP53
8
Show member pathways
Cell cycle37
9.0CDKN2A, TP53
99.0TP53, CDKN2A
10
Show member pathways
9.0CDKN2A, TP53
11
Show member pathways
9.0TP53, CDKN2A
129.0TP53, CDKN2A
139.0CDKN2A, TP53
14
Show member pathways
DNA damage response37
9.0CDKN2A, TP53
159.0CDKN2A, TP53
169.0CDKN2A, TP53
17
Show member pathways
9.0CDKN2A, TP53
188.5CDKN2A, VIM, TP53

Compounds for genes affiliated with Malignant Mixed Mullerian Tumor

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Compounds related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
12-acetylaminofluorene449.8KRT7, AFP
2tachyplesin i449.8AFP, CDKN2A
3reticulin449.7VIM, KRT7
4mucicarmine449.7VIM, KRT7
510-hydroxycamptothecin449.5TP53, AFP
6b 723449.4KRT7, VIM, AFP
7acnu449.4TP53, CDKN2A
8aristolochic acid44 210.3TP53, VIM
9hpvs449.3TP53, CDKN2A
10azathioprine44 2 50 1112.3AFP, VIM, CDKN2A
11hematoxylin449.2KRT7, CDKN2A, VIM
12folate449.2AFP, VIM, CDKN2A
135-methylcytosine44 2410.2CDKN2A, TP53
14valine449.2CDKN2A, VIM, AFP
15olomoucine44 1110.2CDKN2A, TP53
16agar449.2VIM, CDKN2A, AFP
17chloramphenicol44 2 50 1112.2CDKN2A, VIM, AFP
18hmba449.1TP53, CDKN2A
19vinblastine44 50 1111.1AFP, TP53, VIM
20aflatoxin b144 2410.0CDKN2A, TP53
21glycogen44 2410.0VIM, AFP, KRT7
22irinotecan44 50 1111.0TP53, CDKN2A, AFP
23temozolomide44 119.9CDKN2A, VIM, TP53
24o6-methylguanine448.9CDKN2A, TP53
25roscovitine448.9CDKN2A, TP53, VIM
26etoposide44 50 61 1111.9VIM, AFP, TP53
27thymidylate448.9TP53, VIM, CDKN2A
285fluorouracil448.9CDKN2A, TP53, AFP
29retinoid448.9VIM, KRT7, TP53
30cytarabine44 50 1110.9TP53, VIM, CDKN2A
31methotrexate50 44 1110.8VIM, AFP, CDKN2A, KRT7
32iron44 249.8VIM, KRT7, CDKN2A, AFP
33bcnu448.7TP53, CDKN2A
34testosterone44 61 24 1111.7KRT7, AFP, CDKN2A, VIM
35vincristine44 50 1110.5CDKN2A, VIM, TP53, AFP
36adriamycin448.5CDKN2A, VIM, AFP, TP53
37butyrate448.5CDKN2A, AFP, VIM, TP53
38paclitaxel44 50 1110.5TP53, VIM, CDKN2A, AFP
39doxorubicin44 50 1110.5TP53, AFP, VIM, CDKN2A
40actinomycin d448.5AFP, TP53, VIM, CDKN2A
41lipid448.5CDKN2A, KRT7, AFP, VIM
42h2o2448.4AFP, VIM, CDKN2A, TP53
435-aza-2deoxycytidine448.4TP53, CDKN2A, KRT7, VIM
44oligonucleotide448.4TP53, CDKN2A, VIM, AFP
45arginine448.3KRT7, VIM, TP53, CDKN2A
46paraffin448.0KRT7, CDKN2A, VIM, TP53, AFP
47progesterone44 28 61 24 1112.0CDKN2A, KRT7, AFP, TP53, VIM
48vegf448.0AFP, TP53, KRT7, VIM, CDKN2A
49estrogen448.0TP53, VIM, AFP, KRT7, CDKN2A
50retinoic acid44 249.0TP53, CDKN2A, AFP, KRT7, VIM

GO Terms for genes affiliated with Malignant Mixed Mullerian Tumor

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Cellular components related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.4KRT7, VIM
2nuclear bodyGO:0166048.9CDKN2A, TP53
3cytoplasmGO:0057377.2CDKN2A, KRT7, VIM, TP53, AFP

Biological processes related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.1CDKN2A, TP53
2positive regulation of cell cycle arrestGO:0711589.1CDKN2A, TP53
3cell cycle arrestGO:0070509.0CDKN2A, TP53
4Ras protein signal transductionGO:0072658.9CDKN2A, TP53
5negative regulation of cell growthGO:0303088.7CDKN2A, TP53
6viral processGO:0160328.6TP53, VIM, KRT7

Molecular functions related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.0CDKN2A, TP53
2MDM2/MDM4 family protein bindingGO:0973718.7CDKN2A, TP53

Products for genes affiliated with Malignant Mixed Mullerian Tumor

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Sources for Malignant Mixed Mullerian Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet