MMMT
MCID: MLG098
MIFTS: 45

Malignant Mixed Mullerian Tumor (MMMT) malady

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Summaries for Malignant Mixed Mullerian Tumor

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 A malignant mixed müllerian tumor (mmmt), also called a carcinosarcoma, is a type of cancer that contains two types of cells, known as the adenocarcinoma and sarcoma types. these tumors usually develop in tissues of the female genital tract and are associated with a poor outcome. the majority of these tumors arise in the uterus, though they can also occur in the ovaries, fallopian tubes, and cervix. very rarely, mmmts can develop in the female peritoneum (lining of the abdominal wall). last updated: 12/6/2011

MalaCards: Malignant Mixed Mullerian Tumor, also known as carcinosarcoma, is related to leiomyosarcoma and adenocarcinoma. An important gene associated with Malignant Mixed Mullerian Tumor is AFP (alpha-fetoprotein), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Direct p53 effectors. The compounds 2-acetylaminofluorene and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and cervix, and related mouse phenotypes are tumorigenesis and reproductive system.

Aliases & Classifications for Malignant Mixed Mullerian Tumor

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43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

malignant mixed mullerian tumor 43
carcinosarcoma 43 10 45 62
mixed tumor, mullerian 43 62
malignant mixed mesodermal tumor 62
mixed mullerian tumor 43
mixed tumor mullerian 45
mmmt 43


Related Diseases for Malignant Mixed Mullerian Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Malignant Mixed Mullerian Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma30.5TP53, VIM
2adenocarcinoma30.4TP53, AFP, CDKN2A, VIM, KRT7
3papilloma30.4TP53, CDKN2A
4rhabdomyosarcoma30.4VIM, TP53
5breast cancer30.4KRT7, VIM, TP53
6endometrial carcinoma30.4TP53, CDKN2A, KRT7
7lung cancer30.4TP53, CDKN2A, KRT7
8basal cell carcinoma30.2TP53, KRT7
9adenoma30.2CDKN2A, KRT7, TP53
10teratoma30.1KRT7, AFP
11tubular adenocarcinoma29.9KRT7, AFP
12chordoma29.9KRT7, VIM
13wilms tumor29.8KRT7, VIM
14colorectal cancer29.8TP53, KRT7, CDKN2A
15melanoma29.7TP53, VIM, CDKN2A
16uterine carcinosarcoma10.9
17ovarian carcinosarcoma10.5
18sarcoma10.5
19peritonitis10.4
20esophagitis10.3
21papillary serous adenocarcinoma10.3
22endocervicitis10.3
23bilateral breast cancer10.3
24cervical carcinosarcoma10.3
25cervicitis10.3
26endometriosis10.3
27fallopian tube carcinosarcoma10.3
28myasthenia gravis10.3
29nephrotic syndrome10.3
30pancreatitis10.3
31vaginal carcinosarcoma10.3
32superior vena cava syndrome10.3
33blastoma10.3
34uterine sarcoma10.3
35bladder diverticulum10.2
36prostatitis10.2
37pulmonary blastoma10.2
38pleomorphic adenoma10.2
39spindle cell carcinoma10.2
40endometrial stromal sarcoma10.2
41spiradenoma10.1
42endometrial adenocarcinoma10.1
43pseudomyxoma peritonei10.1KRT7
44metanephric adenoma10.1KRT7
45liver sarcoma10.1AFP
46actinic keratosis10.1TP53
47choroid plexus papilloma10.1TP53
48meningioma10.1VIM
49sertoli cell tumor10.1VIM
50adenomatoid tumor10.1VIM

Graphical network of the top 20 diseases related to Malignant Mixed Mullerian Tumor:



Diseases related to malignant mixed mullerian tumor

Symptoms for Malignant Mixed Mullerian Tumor

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Drugs & Therapeutics for Malignant Mixed Mullerian Tumor

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Malignant Mixed Mullerian Tumor

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Anatomical Context for Malignant Mixed Mullerian Tumor

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33MalaCards
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MalaCards organs/tissues related to Malignant Mixed Mullerian Tumor:

33
Ovary, Uterus, Cervix, Lung, Breast

Animal Models for Malignant Mixed Mullerian Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Malignant Mixed Mullerian Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3CDKN2A, TP53, AFP
2MP:00053898.1CDKN2A, VIM, TP53, AFP
3MP:00053848.0CDKN2A, KRT7, VIM, TP53
4MP:00053868.0AFP, TP53, VIM, CDKN2A

Publications for Malignant Mixed Mullerian Tumor

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52PubMed
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Articles related to Malignant Mixed Mullerian Tumor:

(show all 46)
idTitleAuthorsYear
1
ANNA-1 (anti-Hu) associated sensory neuronopathy with malignant mixed mullerian tumor. (23536385)
2013
2
Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report. (24293882)
2012
3
Malignant mixed mullerian tumor: an immunohistochemical study. (22848863)
2012
4
Malignant mixed Mullerian tumor of the ovary with two cases and review of the literature. (21298439)
2011
5
Uncommon manifestations of Endocervical Malignant Mixed Mullerian Tumor with Incidental Bilateral Fallopian Tube Carcinoma. (21701666)
2011
6
Ovarian malignant mixed mullerian tumor with primitive neuroectodermal differentiation: case report with review of the literature. (20950943)
2011
7
Malignant mixed Mullerian tumor of broad ligament with synchronous ovarian and endometrial carcinoma: a rare association. (21546752)
2011
8
Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review. (20882897)
2010
9
Comparative analysis of P16 and P53 expression in uterine malignant mixed mullerian tumors. (19851197)
2009
10
Intracardiac metastasis of a Malignant Mixed Mullerian tumor (MMMT): progressive dyspnoea due to obstruction of the left atrium and the left ventricle without left ventricular dysfunction or primary lung disease. (19652943)
2009
11
Homologous type of malignant mixed Mullerian tumor of the uterus presenting as a cervical mass. (19837648)
2009
12
Biopsy-proven cerebellar metastasis from a malignant mixed mullerian tumor (MMMT) of the uterus: case report. (19480254)
2009
13
Bilateral ovarian malignant mixed Mullerian tumor in a dog. (19176505)
2009
14
Extra genital heterologous malignant mixed mullerian tumor of primary peritoneal origin. (19136793)
2009
15
CT imaging of a primary malignant mixed mullerian tumor arising from the peritoneum. (18760728)
2008
16
Malignant mixed mullerian tumor of the urinary bladder in a 73 year old woman. (18559304)
2008
17
Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI. (18562759)
2008
18
Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus. (17640554)
2007
19
Malignant mixed mullerian tumor in a rabbit (Oryctolagus cuniculus): case report with immunohistochemistry. (16847001)
2006
20
Diagnostic dilemma in a case of malignant mixed mullerian tumor of the cervix. (16813659)
2006
21
Primary malignant mixed Mullerian tumor arising in the rectosigmoid. (16612719)
2006
22
Paraneoplastic subacute sensory neuronopathy secondary to a malignant mixed mullerian tumor. (16449165)
2006
23
Pancreatic metastasis of an ovarian malignant mixed Mullerian tumor identified by EUS-guided fine needle aspiration and Trucut needle biopsy. (16407622)
2006
24
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene. (15863610)
2005
25
Presentation with superior vena cava syndrome secondary to solitary lung metastasis mimicking primary lung cancer following resection of a uterine malignant mixed mullerian tumor: brief case report. (15653218)
2005
26
Primary peritoneal carcinosarcoma (malignant mixed mullerian tumor): Report of a case with five-year disease free survival after surgery and chemoradiation and a review of literature. (16227168)
2005
27
Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma. (15790462)
2005
28
Primary malignant mixed mullerian tumor of the vagina immunohistochemically confirmed. (14735374)
2005
29
Malignant mixed mullerian tumor (MMMT) of the cervix. (15863143)
2005
30
Comment on "Malignant mixed Mullerian tumor of the ovary: an argument for BRCA3 or a coincidental cluster of unconnected cancer". (15582005)
2004
31
Malignant mixed Mullerian tumor of the ovary growing into an inguinal hernia sac: report of a case. (14513334)
2003
32
Malignant mixed mullerian tumor of the ovary and bilateral breast cancer: an argument for BRCA3, or a coincidental cluster of unconnected cancers? (14599878)
2003
33
Malignant mixed Mullerian tumor of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma component. (14599882)
2003
34
Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation. (11975686)
2002
35
Malignant mixed mullerian tumor of the ovary: report of four cases. (11321500)
2001
36
Good response of malignant mixed mullerian tumor of the ovary to paclitaxel and cisplatin chemotherapy. (10609493)
1999
37
Myasthenia gravis associated with malignant mixed Mullerian tumor of the uterus. (9062162)
1997
38
Malignant Mixed Mullerian Tumor of the Extra-genital Coelomic Epithelium: Report of Two Cases. (11173640)
1997
39
Malignant mixed mullerian tumor of the female peritoneum: treatment and outcome of three cases. (9190987)
1997
40
Extragenital malignant mixed mullerian tumor. (8386082)
1993
41
Complex karyotypic aberrations, including i(12p), in malignant mixed mullerian tumor of uterus. (1317254)
1992
42
Malignant mixed mullerian tumor arising in extragenital endometriosis: report of a case and review of the literature. (3002920)
1986
43
Malignant mixed Mullerian tumor of the fallopian tube. Report of a case and review of literature. (6247252)
1980
44
Malignant mixed mullerian tumor of the cervix following cyclophosphamide therapy for nephrotic syndrome. (4346219)
1973
45
CYTOLOGIC FINDINGS ASSOCIATED WITH PRIMARY UTERINE MALIGNANCIES OF MIXED CELL TYPES (MALIGNANT MIXED MULLERIAN TUMOR). (14192726)
1964
46
Malignant mixed mullerian tumor. (13182583)
1954

Variations for Malignant Mixed Mullerian Tumor

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Expression for genes affiliated with Malignant Mixed Mullerian Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Mixed Mullerian Tumor

Search GEO for disease gene expression data for Malignant Mixed Mullerian Tumor.

Pathways for genes affiliated with Malignant Mixed Mullerian Tumor

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 30KEGG
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Pathways related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4VIM, KRT7
29.2AFP, TP53
39.2TP53, AFP
49.1TP53, VIM
59.0TP53, CDKN2A
6
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.0CDKN2A, TP53
79.0TP53, CDKN2A
8
Show member pathways
9.0TP53, CDKN2A
9
Show member pathways
Cell cycle38
9.0CDKN2A, TP53
10
Show member pathways
9.0TP53, CDKN2A
119.0CDKN2A, TP53
129.0CDKN2A, TP53
139.0TP53, CDKN2A
149.0CDKN2A, TP53
15
Show member pathways
9.0CDKN2A, TP53
16
Show member pathways
9.0TP53, CDKN2A
17
Show member pathways
DNA damage response38
9.0CDKN2A, TP53
188.5CDKN2A, VIM, TP53

Compounds for genes affiliated with Malignant Mixed Mullerian Tumor

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45Novoseek, 3BitterDB, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
12-acetylaminofluorene459.8KRT7, AFP
2tachyplesin i459.8AFP, CDKN2A
3reticulin459.7VIM, KRT7
4mucicarmine459.7VIM, KRT7
510-hydroxycamptothecin459.5TP53, AFP
6b 723459.4KRT7, VIM, AFP
7acnu459.4TP53, CDKN2A
8aristolochic acid45 310.3TP53, VIM
9hpvs459.3TP53, CDKN2A
10azathioprine45 3 51 1112.3AFP, VIM, CDKN2A
11hematoxylin459.2KRT7, CDKN2A, VIM
12folate459.2AFP, VIM, CDKN2A
135-methylcytosine45 2410.2CDKN2A, TP53
14valine459.2CDKN2A, VIM, AFP
15olomoucine45 1110.2CDKN2A, TP53
16agar459.2VIM, CDKN2A, AFP
17chloramphenicol45 3 51 1112.2CDKN2A, VIM, AFP
18hmba459.1TP53, CDKN2A
19vinblastine45 51 1111.1AFP, TP53, VIM
20aflatoxin b145 2410.0CDKN2A, TP53
21glycogen45 2410.0VIM, AFP, KRT7
22irinotecan45 51 1111.0TP53, CDKN2A, AFP
23temozolomide45 119.9CDKN2A, VIM, TP53
24o6-methylguanine458.9CDKN2A, TP53
25roscovitine458.9CDKN2A, TP53, VIM
26etoposide45 51 61 1111.9VIM, AFP, TP53
27thymidylate458.9TP53, VIM, CDKN2A
285fluorouracil458.9CDKN2A, TP53, AFP
29retinoid458.9VIM, KRT7, TP53
30cytarabine45 51 1110.9TP53, VIM, CDKN2A
31methotrexate51 45 1110.8VIM, AFP, CDKN2A, KRT7
32iron45 249.8VIM, KRT7, CDKN2A, AFP
33bcnu458.7TP53, CDKN2A
34testosterone45 61 24 1111.7KRT7, AFP, CDKN2A, VIM
35vincristine45 51 1110.5CDKN2A, VIM, TP53, AFP
36adriamycin458.5CDKN2A, VIM, AFP, TP53
37butyrate458.5CDKN2A, AFP, VIM, TP53
38paclitaxel45 51 1110.5TP53, VIM, CDKN2A, AFP
39doxorubicin45 51 1110.5TP53, AFP, VIM, CDKN2A
40actinomycin d458.5AFP, TP53, VIM, CDKN2A
41lipid458.5CDKN2A, KRT7, AFP, VIM
42h2o2458.4AFP, VIM, CDKN2A, TP53
435-aza-2deoxycytidine458.4TP53, CDKN2A, KRT7, VIM
44oligonucleotide458.4TP53, CDKN2A, VIM, AFP
45arginine458.3KRT7, VIM, TP53, CDKN2A
46paraffin458.0KRT7, CDKN2A, VIM, TP53, AFP
47progesterone45 29 61 24 1112.0CDKN2A, KRT7, AFP, TP53, VIM
48vegf458.0AFP, TP53, KRT7, VIM, CDKN2A
49estrogen458.0TP53, VIM, AFP, KRT7, CDKN2A
50retinoic acid45 249.0TP53, CDKN2A, AFP, KRT7, VIM

GO Terms for genes affiliated with Malignant Mixed Mullerian Tumor

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16Gene Ontology
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Cellular components related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.4KRT7, VIM
2nuclear bodyGO:0166048.9CDKN2A, TP53
3cytoplasmGO:0057377.2CDKN2A, KRT7, VIM, TP53, AFP

Biological processes related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:0903999.1CDKN2A, TP53
2positive regulation of cell cycle arrestGO:0711589.1CDKN2A, TP53
3cell cycle arrestGO:0070509.0CDKN2A, TP53
4Ras protein signal transductionGO:0072658.9CDKN2A, TP53
5negative regulation of cell growthGO:0303088.7CDKN2A, TP53
6viral processGO:0160328.6TP53, VIM, KRT7

Molecular functions related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:0020399.0CDKN2A, TP53
2MDM2/MDM4 family protein bindingGO:0973718.7CDKN2A, TP53

Products for genes affiliated with Malignant Mixed Mullerian Tumor

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Sources for Malignant Mixed Mullerian Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet