MMMT
MCID: MLG098
MIFTS: 40

Malignant Mixed Mullerian Tumor (MMMT) malady

Cancer category

Summaries for Malignant Mixed Mullerian Tumor

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 A malignant mixed müllerian tumor (mmmt), also called a carcinosarcoma, is a type of cancer that contains two types of cells, known as the adenocarcinoma and sarcoma types. these tumors usually develop in tissues of the female genital tract and are associated with a poor outcome. the majority of these tumors arise in the uterus, though they can also occur in the ovaries, fallopian tubes, and cervix. very rarely, mmmts can develop in the female peritoneum (lining of the abdominal wall). last updated: 12/6/2011

MalaCards: Malignant Mixed Mullerian Tumor, also known as carcinosarcoma, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Malignant Mixed Mullerian Tumor is AFP (alpha-fetoprotein), and among its related pathways are Gastric cancer network 2 and TP53 network. The compounds nickel and hpaii have been mentioned in the context of this disorder. Affiliated tissues include ovary, lung and uterus, and related mouse phenotypes are homeostasis/metabolism and reproductive system.

Aliases & Classifications for Malignant Mixed Mullerian Tumor

Sources:
43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

malignant mixed mullerian tumor 43
carcinosarcoma 43 10 45 61
mixed tumor, mullerian 43 61
malignant mixed mesodermal tumor 61
mixed mullerian tumor 43
mixed tumor mullerian 45
mmmt 43


Related Diseases for Malignant Mixed Mullerian Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Malignant Mixed Mullerian Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 185)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.5CDKN2A, AFP, H19, VIM, CDH3, KRT7
2squamous cell carcinoma30.4VIM, H19, CDKN2A, CDH3, KRT7, TP53
3basal cell carcinoma30.3TP53, KRT7, CDH3
4adenoma30.2H19, CDKN2A, CDH3, KRT7, TP53
5bladder carcinoma30.1TP53, CDKN2A, H19
6teratoma30.0KRT7, AFP, H19
7sertoli cell tumor29.8VIM
8rhabdoid tumor29.8VIM
9angiosarcoma29.8VIM
10tubular adenocarcinoma29.8KRT7, AFP
11spindle cell sarcoma29.8KRT7, VIM
12wilms tumor29.8VIM, H19, KRT7
13colorectal cancer29.7CDKN2A, KRT7, TP53
14uterine carcinosarcoma10.9
15uterine sarcoma10.5
16endocervical carcinoma10.3
17papillary serous adenocarcinoma10.3
18fallopian tube serous adenocarcinoma10.3
19fallopian tube papillary adenocarcinoma10.3
20n syndrome10.3
21bilateral breast cancer10.3
22vaginal carcinosarcoma10.3
23superior vena cava syndrome10.3
24blastoma10.3
25bladder diverticulum10.3
26endometrial mixed adenocarcinoma10.2
27pleomorphic adenoma10.2
28spindle cell carcinoma10.2
29endometrial stromal sarcoma10.2
30spiradenoma10.1
31bladder sarcoma10.1
32neuroendocrine carcinoma10.0
33papillary carcinoma10.0
34pleomorphic carcinoma10.0
35basaloid squamous cell carcinoma10.0
36adenosquamous carcinoma10.0
37large cell carcinoma10.0
38adenosarcoma10.0
39benign vaginal carcinosarcoma10.0
40thymoma10.0
41uterine disease10.0
42malignant mixed epithelial mesenchymal tumor of the ovary10.0
43liver cirrhosis10.0AFP
44endometriosis10.0CDH3
45pituitary adenoma10.0CDH3
46liver sarcoma10.0AFP
47cystadenoma10.0KRT7
48mixed cell type cancer10.0KRT7
49hepatitis c10.0AFP
50testicular cancer10.0AFP

Graphical network of the top 20 diseases related to Malignant Mixed Mullerian Tumor:



Diseases related to malignant mixed mullerian tumor

Clinical Features for Malignant Mixed Mullerian Tumor

Drugs & Therapeutics for Malignant Mixed Mullerian Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Mixed Mullerian Tumor

Anatomical Context for Malignant Mixed Mullerian Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Malignant Mixed Mullerian Tumor:

33
Ovary, Lung, Uterus, Breast, Cervix, Uterus corpus

Animal Models for Malignant Mixed Mullerian Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Malignant Mixed Mullerian Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.3H19, SNRPN, AFP
2MP:00053898.1AFP, CDKN2A, TP53, SNRPN
3MP:00020068.0TP53, CDKN2A, AFP, H19
4MP:00053798.0CDH3, H19, AFP, CDKN2A, TP53
5MP:00053847.1TP53, VIM, H19, SNRPN, CDKN2A, KRT7

Publications for Malignant Mixed Mullerian Tumor

Sources:
51PubMed
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Articles related to Malignant Mixed Mullerian Tumor:

(show all 48)
idTitleAuthorsYear
1
ANNA-1 (anti-Hu) associated sensory neuronopathy with malignant mixed mullerian tumor. (23536385)
2013
2
Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report. (24293882)
2012
3
Malignant mixed mullerian tumor: an immunohistochemical study. (22848863)
2012
4
Malignant mixed Mullerian tumor of the ovary with two cases and review of the literature. (21298439)
2011
5
Uncommon manifestations of Endocervical Malignant Mixed Mullerian Tumor with Incidental Bilateral Fallopian Tube Carcinoma. (21701666)
2011
6
Ovarian malignant mixed mullerian tumor with primitive neuroectodermal differentiation: case report with review of the literature. (20950943)
2011
7
Malignant mixed Mullerian tumor of broad ligament with synchronous ovarian and endometrial carcinoma: a rare association. (21546752)
2011
8
WT1 immunoprofiling and comparison of malignant Mullerian mixed tumors of the female genital tract. (20736771)
2010
9
Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review. (20882897)
2010
10
Comparative analysis of P16 and P53 expression in uterine malignant mixed mullerian tumors. (19851197)
2009
11
Intracardiac metastasis of a Malignant Mixed Mullerian tumor (MMMT): progressive dyspnoea due to obstruction of the left atrium and the left ventricle without left ventricular dysfunction or primary lung disease. (19652943)
2009
12
Homologous type of malignant mixed Mullerian tumor of the uterus presenting as a cervical mass. (19837648)
2009
13
Biopsy-proven cerebellar metastasis from a malignant mixed mullerian tumor (MMMT) of the uterus: case report. (19480254)
2009
14
Bilateral ovarian malignant mixed Mullerian tumor in a dog. (19176505)
2009
15
Extra genital heterologous malignant mixed mullerian tumor of primary peritoneal origin. (19136793)
2009
16
CT imaging of a primary malignant mixed mullerian tumor arising from the peritoneum. (18760728)
2008
17
Malignant mixed mullerian tumor of the urinary bladder in a 73 year old woman. (18559304)
2008
18
Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI. (18562759)
2008
19
Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus. (17640554)
2007
20
Malignant mixed mullerian tumor in a rabbit (Oryctolagus cuniculus): case report with immunohistochemistry. (16847001)
2006
21
Diagnostic dilemma in a case of malignant mixed mullerian tumor of the cervix. (16813659)
2006
22
Primary malignant mixed Mullerian tumor arising in the rectosigmoid. (16612719)
2006
23
Paraneoplastic subacute sensory neuronopathy secondary to a malignant mixed mullerian tumor. (16449165)
2006
24
Pancreatic metastasis of an ovarian malignant mixed Mullerian tumor identified by EUS-guided fine needle aspiration and Trucut needle biopsy. (16407622)
2006
25
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene. (15863610)
2005
26
Presentation with superior vena cava syndrome secondary to solitary lung metastasis mimicking primary lung cancer following resection of a uterine malignant mixed mullerian tumor: brief case report. (15653218)
2005
27
Primary peritoneal carcinosarcoma (malignant mixed mullerian tumor): Report of a case with five-year disease free survival after surgery and chemoradiation and a review of literature. (16227168)
2005
28
Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma. (15790462)
2005
29
Primary malignant mixed mullerian tumor of the vagina immunohistochemically confirmed. (14735374)
2005
30
Malignant mixed mullerian tumor (MMMT) of the cervix. (15863143)
2005
31
Comment on "Malignant mixed Mullerian tumor of the ovary: an argument for BRCA3 or a coincidental cluster of unconnected cancer". (15582005)
2004
32
Malignant mixed Mullerian tumor of the ovary growing into an inguinal hernia sac: report of a case. (14513334)
2003
33
Malignant mixed mullerian tumor of the ovary and bilateral breast cancer: an argument for BRCA3, or a coincidental cluster of unconnected cancers? (14599878)
2003
34
Malignant mixed Mullerian tumor of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma component. (14599882)
2003
35
Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation. (11975686)
2002
36
Malignant mixed mullerian tumor of the ovary: report of four cases. (11321500)
2001
37
Good response of malignant mixed mullerian tumor of the ovary to paclitaxel and cisplatin chemotherapy. (10609493)
1999
38
Malignant mesodermal (Mullerian) mixed tumor of the ovary: histologic, immunohistochemical and cytologic study]. (9702303)
1998
39
Myasthenia gravis associated with malignant mixed Mullerian tumor of the uterus. (9062162)
1997
40
Malignant Mixed Mullerian Tumor of the Extra-genital Coelomic Epithelium: Report of Two Cases. (11173640)
1997
41
Malignant mixed mullerian tumor of the female peritoneum: treatment and outcome of three cases. (9190987)
1997
42
Extragenital malignant mixed mullerian tumor. (8386082)
1993
43
Complex karyotypic aberrations, including i(12p), in malignant mixed mullerian tumor of uterus. (1317254)
1992
44
Malignant mixed mullerian tumor arising in extragenital endometriosis: report of a case and review of the literature. (3002920)
1986
45
Malignant mixed Mullerian tumor of the fallopian tube. Report of a case and review of literature. (6247252)
1980
46
Malignant mixed mullerian tumor of the cervix following cyclophosphamide therapy for nephrotic syndrome. (4346219)
1973
47
CYTOLOGIC FINDINGS ASSOCIATED WITH PRIMARY UTERINE MALIGNANCIES OF MIXED CELL TYPES (MALIGNANT MIXED MULLERIAN TUMOR). (14192726)
1964
48
Malignant mixed mullerian tumor. (13182583)
1954

Genetic Variations for Malignant Mixed Mullerian Tumor

Expression for genes affiliated with Malignant Mixed Mullerian Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Mixed Mullerian Tumor

Search GEO for disease gene expression data for Malignant Mixed Mullerian Tumor.

Pathways for genes affiliated with Malignant Mixed Mullerian Tumor

Sources:
38NCBI BioSystems Database, 52QIAGEN, 30KEGG
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Pathways related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2SNRPN, TP53
29.0CDKN2A, TP53
39.0CDKN2A, TP53
48.8VIM, CDH3, TP53
58.5VIM, CDKN2A, TP53

Compounds for genes affiliated with Malignant Mixed Mullerian Tumor

Sources:
45Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1nickel45 2411.1AFP
2hpaii459.9SNRPN, H19
3tachyplesin i459.9AFP, CDKN2A
4reticulin459.8KRT7, VIM
5mucicarmine459.8VIM, KRT7
610-hydroxycamptothecin459.7TP53, AFP
7b 723459.5AFP, KRT7, VIM
8cytosine45 2410.5CDKN2A, AFP, H19
9aristolochic acid45 210.4TP53, VIM
10acnu459.4CDKN2A, TP53
11hpvs459.4TP53, CDKN2A
12folate459.3VIM, AFP, CDKN2A
135-methylcytosine45 2410.3TP53, CDKN2A
14olomoucine45 1110.3CDKN2A, TP53
15valine459.3VIM, AFP, CDKN2A
16hmba459.2CDKN2A, TP53
17hematoxylin459.2KRT7, CDKN2A, VIM
18aflatoxin b145 2410.2CDKN2A, TP53
19chloramphenicol45 2 1111.2VIM, CDKN2A, AFP
20vinblastine45 50 1111.2TP53, VIM, AFP
21o6-methylguanine459.1TP53, CDKN2A
22paclitaxel45 50 1111.1TP53, CDKN2A, AFP
23irinotecan45 50 1111.1AFP, CDKN2A, TP53
24bcnu459.0TP53, CDKN2A
25azathioprine45 50 2 1112.0CDKN2A, AFP, H19, VIM
26agar459.0VIM, H19, AFP, CDKN2A
27temozolomide45 119.9VIM, TP53, CDKN2A
28roscovitine458.9TP53, CDKN2A, VIM
295fluorouracil458.9TP53, AFP, CDKN2A
30methotrexate45 50 1110.9VIM, AFP, KRT7, CDKN2A
31cytarabine45 50 1110.9TP53, VIM, CDKN2A
32thymidylate458.9VIM, TP53, CDKN2A
33iron45 249.8VIM, CDKN2A, KRT7, AFP
34testosterone45 60 11 2411.8KRT7, VIM, AFP, CDKN2A
35retinoid458.8TP53, VIM, KRT7
36paraffin458.8CDH3, VIM, H19, AFP, KRT7
37crcs458.7TP53, CDKN2A
38etoposide45 50 60 1111.7AFP, TP53, VIM
39vincristine45 50 1110.6VIM, AFP, CDKN2A, TP53
40adriamycin458.6VIM, CDKN2A, AFP, TP53
41doxorubicin45 50 1110.6CDKN2A, VIM, TP53, AFP
42actinomycin d458.6AFP, CDKN2A, TP53, VIM
43h2o2458.5AFP, VIM, TP53, CDKN2A
44oligonucleotide458.4CDKN2A, TP53, AFP, VIM
45arginine458.1VIM, TP53, KRT7, CDKN2A
46vegf458.1VIM, TP53, AFP, CDKN2A, KRT7
47progesterone45 60 29 11 2411.7KRT7, VIM, CDH3, TP53, CDKN2A, AFP
48retinoic acid45 248.7AFP, CDKN2A, TP53, H19, VIM, KRT7
495-aza-2deoxycytidine457.6H19, VIM, CDKN2A, KRT7, SNRPN, TP53

GO Terms for genes affiliated with Malignant Mixed Mullerian Tumor

Sources:
16Gene Ontology
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Cellular components related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.0TP53, CDKN2A

Biological processes related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell cycle arrestGO:0711589.0TP53, CDKN2A
2replicative senescenceGO:0903998.7TP53, CDKN2A

Molecular functions related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.0TP53, CDKN2A

Products for genes affiliated with Malignant Mixed Mullerian Tumor

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Sources for Malignant Mixed Mullerian Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet