MCID: MLG098
MIFTS: 38

Malignant Mixed Mullerian Tumor malady

Rare diseases, Cancer diseases categories

Summaries for Malignant Mixed Mullerian Tumor

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NIH Rare Diseases:41 A malignant mixed müllerian tumor (mmmt), also called a carcinosarcoma, is a type of cancer that contains two types of cells, known as the adenocarcinoma and sarcoma types. these tumors usually develop in tissues of the female genital tract and are associated with a poor outcome. the majority of these tumors arise in the uterus, though they can also occur in the ovaries, fallopian tubes, and cervix. very rarely, mmmts can develop in the female peritoneum (lining of the abdominal wall). last updated: 12/6/2011

MalaCards based summary: Malignant Mixed Mullerian Tumor, also known as carcinosarcoma, is related to leiomyosarcoma and basal cell carcinoma. An important gene associated with Malignant Mixed Mullerian Tumor is AFP (alpha-fetoprotein), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Glucocorticoid receptor regulatory network. The compounds 2-acetylaminofluorene and tachyplesin i have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and cervix, and related mouse phenotypes are tumorigenesis and reproductive system.

Aliases & Classifications for Malignant Mixed Mullerian Tumor

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Sources:
41NIH Rare Diseases, 11DISEASES, 43Novoseek, 60UMLS
See all sources

Malignant Mixed Mullerian Tumor, Aliases & Descriptions:

Name: Malignant Mixed Mullerian Tumor 41
Carcinosarcoma 41 11 43 60
Mixed Tumor, Mullerian 41 60
Malignant Mixed Mesodermal Tumor 60
 
Mixed Mullerian Tumor 41
Mixed Tumor Mullerian 43
Mmmt 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Malignant Mixed Mullerian Tumor

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Diseases related to Malignant Mixed Mullerian Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1leiomyosarcoma30.8VIM, TP53
2basal cell carcinoma30.5KRT7, TP53
3papilloma30.5CDKN2A, TP53
4rhabdomyosarcoma30.4VIM, TP53
5teratoma30.4AFP, KRT7
6breast cancer30.3TP53, VIM, KRT7
7tubular adenocarcinoma30.2KRT7, AFP
8adenoma30.1TP53, KRT7, CDKN2A
9chordoma30.1KRT7, VIM
10lung cancer30.1TP53, CDKN2A
11liposarcoma30.1VIM, TP53
12wilms tumor29.8KRT7, VIM
13adenocarcinoma29.8AFP, TP53, VIM, KRT7, CDKN2A
14endometrial cancer29.7CDKN2A, KRT7, TP53
15mesothelioma29.6CDKN2A, KRT7, VIM
16colorectal cancer29.5TP53, KRT7, CDKN2A
17melanoma29.2CDKN2A, VIM, TP53
18uterine carcinosarcoma11.0
19ovarian carcinosarcoma10.5
20sarcoma10.5
21pseudomyxoma peritonei10.5KRT7
22metanephric adenoma10.5KRT7
23peritonitis10.5
24liver sarcoma10.4AFP
25actinic keratosis10.4TP53
26choroid plexus papilloma10.4TP53
27meningioma, familial10.4VIM
28sertoli cell tumor10.4VIM
29adenomatoid tumor10.4VIM
30esophagitis10.4
31uterine sarcoma10.3
32myasthenia gravis10.3
33papillary serous adenocarcinoma10.3
34endocervicitis10.3
35bilateral breast cancer10.3
36cervical carcinosarcoma10.3
37cervicitis10.3
38endometriosis10.3
39fallopian tube carcinosarcoma10.3
40leiomyoma10.3
41nephrotic syndrome10.3
42pancreatitis10.3
43vaginal carcinosarcoma10.3
44superior vena cava syndrome10.3
45blastoma10.3
46spindle cell carcinoma10.3
47bladder diverticulum10.3
48pleomorphic adenoma10.2
49endometrial stromal sarcoma10.2
50prostatitis10.2

Graphical network of the top 20 diseases related to Malignant Mixed Mullerian Tumor:



Diseases related to malignant mixed mullerian tumor

Symptoms for Malignant Mixed Mullerian Tumor

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Drugs & Therapeutics for Malignant Mixed Mullerian Tumor

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Drug clinical trials:

Search ClinicalTrials for Malignant Mixed Mullerian Tumor

Search NIH Clinical Center for Malignant Mixed Mullerian Tumor

Genetic Tests for Malignant Mixed Mullerian Tumor

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Anatomical Context for Malignant Mixed Mullerian Tumor

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MalaCards organs/tissues related to Malignant Mixed Mullerian Tumor:

31
Ovary, Uterus, Cervix, Lung, Breast

Animal Models for Malignant Mixed Mullerian Tumor or affiliated genes

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MGI Mouse Phenotypes related to Malignant Mixed Mullerian Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3CDKN2A, TP53, AFP
2MP:00053898.1CDKN2A, VIM, TP53, AFP
3MP:00053848.0CDKN2A, KRT7, VIM, TP53
4MP:00053868.0AFP, TP53, VIM, CDKN2A

Publications for Malignant Mixed Mullerian Tumor

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Articles related to Malignant Mixed Mullerian Tumor:

(show all 49)
idTitleAuthorsYear
1
Prolonged survival of a patient with pelvic recurrence of ovarian malignant mixed mullerian tumor after chemoradiotherapy. (25593719)
2014
2
Endometrioid carcinoma infiltrating atypical leiomyoma: a mimicker of malignant mixed Mullerian tumor. (24943777)
2014
3
F-18 fluorodeoxyglucose positron emission tomography/computed tomography in a rare case of recurrent malignant mixed mullerian tumor. (25191116)
2014
4
Malignant mixed mullerian tumor of the ovary. (25404814)
2014
5
ANNA-1 (anti-Hu) associated sensory neuronopathy with malignant mixed mullerian tumor. (23536385)
2013
6
Malignant mixed mullerian tumor of endometrium coexisting with bilateral papillary serous adenocarcinoma of fallopian tube: a rare case report. (24293882)
2012
7
Malignant mixed mullerian tumor: an immunohistochemical study. (22848863)
2012
8
Malignant mixed Mullerian tumor of the ovary with two cases and review of the literature. (21298439)
2011
9
Uncommon manifestations of Endocervical Malignant Mixed Mullerian Tumor with Incidental Bilateral Fallopian Tube Carcinoma. (21701666)
2011
10
Ovarian malignant mixed mullerian tumor with primitive neuroectodermal differentiation: case report with review of the literature. (20950943)
2011
11
Malignant mixed Mullerian tumor of broad ligament with synchronous ovarian and endometrial carcinoma: a rare association. (21546752)
2011
12
Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review. (20882897)
2010
13
Comparative analysis of P16 and P53 expression in uterine malignant mixed mullerian tumors. (19851197)
2009
14
Intracardiac metastasis of a Malignant Mixed Mullerian tumor (MMMT): progressive dyspnoea due to obstruction of the left atrium and the left ventricle without left ventricular dysfunction or primary lung disease. (19652943)
2009
15
Homologous type of malignant mixed Mullerian tumor of the uterus presenting as a cervical mass. (19837648)
2009
16
Biopsy-proven cerebellar metastasis from a malignant mixed mullerian tumor (MMMT) of the uterus: case report. (19480254)
2009
17
Bilateral ovarian malignant mixed Mullerian tumor in a dog. (19176505)
2009
18
Extra genital heterologous malignant mixed mullerian tumor of primary peritoneal origin. (19136793)
2009
19
CT imaging of a primary malignant mixed mullerian tumor arising from the peritoneum. (18760728)
2008
20
Malignant mixed mullerian tumor of the urinary bladder in a 73 year old woman. (18559304)
2008
21
Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI. (18562759)
2008
22
Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus. (17640554)
2007
23
Malignant mixed mullerian tumor in a rabbit (Oryctolagus cuniculus): case report with immunohistochemistry. (16847001)
2006
24
Diagnostic dilemma in a case of malignant mixed mullerian tumor of the cervix. (16813659)
2006
25
Primary malignant mixed Mullerian tumor arising in the rectosigmoid. (16612719)
2006
26
Paraneoplastic subacute sensory neuronopathy secondary to a malignant mixed mullerian tumor. (16449165)
2006
27
Pancreatic metastasis of an ovarian malignant mixed Mullerian tumor identified by EUS-guided fine needle aspiration and Trucut needle biopsy. (16407622)
2006
28
Malignant mixed mullerian tumor of the uterus in a patient taking raloxifene. (15863610)
2005
29
Presentation with superior vena cava syndrome secondary to solitary lung metastasis mimicking primary lung cancer following resection of a uterine malignant mixed mullerian tumor: brief case report. (15653218)
2005
30
Primary peritoneal carcinosarcoma (malignant mixed mullerian tumor): Report of a case with five-year disease free survival after surgery and chemoradiation and a review of literature. (16227168)
2005
31
Malignant mixed Mullerian tumor of the fimbriated end of the fallopian tube: origin as an intraepithelial carcinoma. (15790462)
2005
32
Primary malignant mixed mullerian tumor of the vagina immunohistochemically confirmed. (14735374)
2005
33
Malignant mixed mullerian tumor (MMMT) of the cervix. (15863143)
2005
34
Comment on "Malignant mixed Mullerian tumor of the ovary: an argument for BRCA3 or a coincidental cluster of unconnected cancer". (15582005)
2004
35
Malignant mixed Mullerian tumor of the ovary growing into an inguinal hernia sac: report of a case. (14513334)
2003
36
Malignant mixed mullerian tumor of the ovary and bilateral breast cancer: an argument for BRCA3, or a coincidental cluster of unconnected cancers? (14599878)
2003
37
Malignant mixed Mullerian tumor of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma component. (14599882)
2003
38
Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation. (11975686)
2002
39
Malignant mixed mullerian tumor of the ovary: report of four cases. (11321500)
2001
40
Good response of malignant mixed mullerian tumor of the ovary to paclitaxel and cisplatin chemotherapy. (10609493)
1999
41
Myasthenia gravis associated with malignant mixed Mullerian tumor of the uterus. (9062162)
1997
42
Malignant Mixed Mullerian Tumor of the Extra-genital Coelomic Epithelium: Report of Two Cases. (11173640)
1997
43
Malignant mixed mullerian tumor of the female peritoneum: treatment and outcome of three cases. (9190987)
1997
44
Extragenital malignant mixed mullerian tumor. (8386082)
1993
45
Complex karyotypic aberrations, including i(12p), in malignant mixed mullerian tumor of uterus. (1317254)
1992
46
Malignant mixed mullerian tumor arising in extragenital endometriosis: report of a case and review of the literature. (3002920)
1986
47
Malignant mixed Mullerian tumor of the fallopian tube. Report of a case and review of literature. (6247252)
1980
48
Malignant mixed mullerian tumor of the cervix following cyclophosphamide therapy for nephrotic syndrome. (4346219)
1973
49
CYTOLOGIC FINDINGS ASSOCIATED WITH PRIMARY UTERINE MALIGNANCIES OF MIXED CELL TYPES (MALIGNANT MIXED MULLERIAN TUMOR). (14192726)
1964

Variations for Malignant Mixed Mullerian Tumor

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Expression for genes affiliated with Malignant Mixed Mullerian Tumor

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Search GEO for disease gene expression data for Malignant Mixed Mullerian Tumor.

Pathways for genes affiliated with Malignant Mixed Mullerian Tumor

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Pathways related to Malignant Mixed Mullerian Tumor according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4KRT7, VIM
29.2AFP, TP53
39.2TP53, AFP
49.1TP53, VIM
5
Show member pathways
9.0CDKN2A, TP53
69.0CDKN2A, TP53
7
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.0CDKN2A, TP53
8
Show member pathways
Cell cycle36
9.0CDKN2A, TP53
99.0TP53, CDKN2A
10
Show member pathways
9.0CDKN2A, TP53
11
Show member pathways
9.0TP53, CDKN2A
129.0TP53, CDKN2A
139.0CDKN2A, TP53
14
Show member pathways
DNA damage response36
9.0CDKN2A, TP53
159.0CDKN2A, TP53
169.0CDKN2A, TP53
17
Show member pathways
9.0CDKN2A, TP53
188.5CDKN2A, VIM, TP53

Compounds for genes affiliated with Malignant Mixed Mullerian Tumor

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Compounds related to Malignant Mixed Mullerian Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
12-acetylaminofluorene439.8AFP, KRT7
2tachyplesin i439.8AFP, CDKN2A
3reticulin439.7KRT7, VIM
4mucicarmine439.7KRT7, VIM
510-hydroxycamptothecin439.5AFP, TP53
6b 723439.4AFP, VIM, KRT7
7acnu439.4CDKN2A, TP53
8aristolochic acid43 210.3TP53, VIM
9hpvs439.3CDKN2A, TP53
10azathioprine43 2 49 1212.3CDKN2A, VIM, AFP
11hematoxylin439.2VIM, KRT7, CDKN2A
12folate439.2CDKN2A, VIM, AFP
13olomoucine43 1210.2CDKN2A, TP53
14valine439.2CDKN2A, VIM, AFP
155-methylcytosine43 2410.2CDKN2A, TP53
16agar439.2CDKN2A, VIM, AFP
17chloramphenicol43 2 49 1212.2AFP, VIM, CDKN2A
18aflatoxin b143 2410.1TP53, CDKN2A
19vinblastine43 49 1211.1VIM, TP53, AFP
20hmba439.0TP53, CDKN2A
21glycogen43 2410.0KRT7, VIM, AFP
22irinotecan43 49 1211.0CDKN2A, TP53, AFP
23temozolomide43 129.9TP53, VIM, CDKN2A
24o6-methylguanine438.9CDKN2A, TP53
25roscovitine438.9CDKN2A, VIM, TP53
26etoposide43 49 59 1211.9VIM, TP53, AFP
27thymidylate438.9TP53, VIM, CDKN2A
285fluorouracil438.9AFP, TP53, CDKN2A
29retinoid438.9TP53, VIM, KRT7
30cytarabine43 49 1210.9TP53, VIM, CDKN2A
31methotrexate49 43 1210.8CDKN2A, KRT7, VIM, AFP
32iron43 249.8AFP, VIM, KRT7, CDKN2A
33bcnu438.7CDKN2A, TP53
34testosterone43 59 24 1211.7AFP, VIM, KRT7, CDKN2A
35vincristine43 49 1210.5AFP, TP53, VIM, CDKN2A
36adriamycin438.5AFP, TP53, VIM, CDKN2A
37butyrate438.5AFP, TP53, VIM, CDKN2A
38paclitaxel43 49 1210.5CDKN2A, VIM, TP53, AFP
39doxorubicin43 49 1210.5AFP, TP53, VIM, CDKN2A
40actinomycin d438.5AFP, TP53, VIM, CDKN2A
41lipid438.5AFP, VIM, KRT7, CDKN2A
42h2o2438.4CDKN2A, VIM, TP53, AFP
435-aza-2deoxycytidine438.4TP53, VIM, KRT7, CDKN2A
44oligonucleotide438.4AFP, TP53, VIM, CDKN2A
45arginine438.3CDKN2A, KRT7, VIM, TP53
46paraffin438.0CDKN2A, KRT7, VIM, TP53, AFP
47progesterone43 28 59 24 1212.0CDKN2A, KRT7, VIM, TP53, AFP
48vegf438.0CDKN2A, KRT7, VIM, TP53, AFP
49estrogen438.0AFP, TP53, VIM, KRT7, CDKN2A
50retinoic acid43 249.0CDKN2A, KRT7, VIM, TP53, AFP

GO Terms for genes affiliated with Malignant Mixed Mullerian Tumor

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Cellular components related to Malignant Mixed Mullerian Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.4KRT7, VIM
2nuclear bodyGO:00166048.9CDKN2A, TP53
3cytoplasmGO:00057377.2CDKN2A, KRT7, VIM, TP53, AFP

Biological processes related to Malignant Mixed Mullerian Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1replicative senescenceGO:00903999.1CDKN2A, TP53
2positive regulation of cell cycle arrestGO:00711589.1CDKN2A, TP53
3cell cycle arrestGO:00070509.0CDKN2A, TP53
4Ras protein signal transductionGO:00072658.9CDKN2A, TP53
5negative regulation of cell growthGO:00303088.7CDKN2A, TP53
6viral processGO:00160328.6TP53, VIM, KRT7

Molecular functions related to Malignant Mixed Mullerian Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00020399.0CDKN2A, TP53
2MDM2/MDM4 family protein bindingGO:00973718.7CDKN2A, TP53

Products for genes affiliated with Malignant Mixed Mullerian Tumor

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Sources for Malignant Mixed Mullerian Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet