MMMT
MCID: MLG098
MIFTS: 35

Malignant Mixed Mullerian Tumor (MMMT) malady

Cancer diseases category

Summaries for Malignant Mixed Mullerian Tumor

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 A malignant mixed müllerian tumor (mmmt), also called a carcinosarcoma, is a type of cancer that contains two types of cells, known as the adenocarcinoma and sarcoma types. these tumors usually develop in tissues of the female genital tract and are associated with a poor outcome. the majority of these tumors arise in the uterus, though they can also occur in the ovaries, fallopian tubes, and cervix. very rarely, mmmts can develop in the female peritoneum (lining of the abdominal wall). last updated: 12/6/2011

MalaCards: Malignant Mixed Mullerian Tumor, also known as carcinosarcoma, is related to sarcoma and adenocarcinoma. An important gene associated with Malignant Mixed Mullerian Tumor is AFP (alpha-fetoprotein), and among its related pathways are Gastric cancer network 2 and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds nickel and hpaii have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and cervix, and related mouse phenotypes are homeostasis/metabolism and reproductive system.

Aliases & Classifications for Malignant Mixed Mullerian Tumor

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42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS
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Classifications:

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Global: Cancer diseases


Aliases & Descriptions:

malignant mixed mullerian tumor 42
carcinosarcoma 42 10 44 60
mixed tumor, mullerian 42 60
malignant mixed mesodermal tumor 60
mixed mullerian tumor 42
mixed tumor mullerian 44
mmmt 42


Related Diseases for Malignant Mixed Mullerian Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Malignant Mixed Mullerian Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1sarcoma30.6VIM, TP53
2adenocarcinoma30.5H19, VIM, CDKN2A, AFP, CDH3, KRT7
3leiomyosarcoma30.4VIM, TP53
4squamous cell carcinoma30.3H19, TP53, KRT7, VIM, CDKN2A, CDH3
5endometriosis30.3CDH3
6papilloma30.3CDKN2A, TP53
7rhabdomyosarcoma30.3VIM, H19, TP53
8lung cancer30.3TP53, H19, KRT7
9endometrial carcinoma30.3TP53, CDH3, CDKN2A
10breast cancer30.3KRT7, CDH3, CDKN2A, TP53, H19
11adenoma30.1TP53, KRT7, CDH3, CDKN2A, H19
12basal cell carcinoma30.1KRT7, CDH3, TP53
13bladder carcinoma30.0H19, CDKN2A, TP53
14nephroblastoma29.9TP53
15chondrosarcoma29.9VIM
16osteosarcoma29.9H19, CDKN2A, TP53
17leiomyoma29.7VIM
18sertoli cell tumor29.7VIM
19angiosarcoma29.7VIM
20tubular adenocarcinoma29.7AFP, KRT7
21chordoma29.7KRT7, VIM
22fibrosarcoma29.7VIM
23spindle cell sarcoma29.7VIM, KRT7
24gastric adenocarcinoma29.7CDH3, AFP, KRT7
25cervical adenocarcinoma29.7CDKN2A, KRT7
26malignant mesothelioma29.7CDKN2A, KRT7, VIM
27melanoma29.7CDH3, VIM, CDKN2A, TP53
28colorectal cancer29.7KRT7, CDKN2A, TP53
29uterine carcinosarcoma10.9
30ovarian carcinosarcoma10.5
31peritonitis10.4
32cystic teratoma10.3
33esophagitis10.2
34endocervical carcinoma10.2
35papillary serous adenocarcinoma10.2
36endocervicitis10.2
37fallopian tube serous adenocarcinoma10.2
38fallopian tube papillary adenocarcinoma10.2
39bilateral breast cancer10.2
40cervical carcinosarcoma10.2
41cervicitis10.2
42fallopian tube adenocarcinoma10.2
43fallopian tube carcinosarcoma10.2
44myasthenia gravis10.2
45nephrotic syndrome10.2
46neuroendocrine tumor10.2
47obstructive lung disease10.2
48pancreatitis10.2
49papillary adenocarcinoma10.2
50primitive neuroectodermal tumor10.2

Graphical network of the top 20 diseases related to Malignant Mixed Mullerian Tumor:



Diseases related to malignant mixed mullerian tumor

Clinical Features for Malignant Mixed Mullerian Tumor

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Drugs & Therapeutics for Malignant Mixed Mullerian Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Mixed Mullerian Tumor

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Anatomical Context for Malignant Mixed Mullerian Tumor

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32MalaCards
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MalaCards organs/tissues related to Malignant Mixed Mullerian Tumor:

32
Ovary, Uterus, Cervix

Animal Models for Malignant Mixed Mullerian Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Mixed Mullerian Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.3H19, SNRPN, AFP
2MP:00053898.1AFP, CDKN2A, TP53, SNRPN
3MP:00020068.0TP53, CDKN2A, AFP, H19
4MP:00053798.0CDH3, H19, AFP, CDKN2A, TP53
5MP:00053847.1TP53, VIM, H19, SNRPN, CDKN2A, KRT7

Publications for Malignant Mixed Mullerian Tumor

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Genetic Variations for Malignant Mixed Mullerian Tumor

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Expression for genes affiliated with Malignant Mixed Mullerian Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Mixed Mullerian Tumor

Search GEO for disease gene expression data for Malignant Mixed Mullerian Tumor.

Pathways for genes affiliated with Malignant Mixed Mullerian Tumor

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 29KEGG
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Pathways related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2TP53, SNRPN
29.0TP53, CDKN2A
39.0TP53, CDKN2A
48.8VIM, CDH3, TP53
58.5TP53, CDKN2A, VIM

Compounds for genes affiliated with Malignant Mixed Mullerian Tumor

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Sources:
44Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1nickel44 2411.1AFP
2hpaii449.9SNRPN, H19
3tachyplesin i449.9AFP, CDKN2A
4reticulin449.8KRT7, VIM
5mucicarmine449.8KRT7, VIM
610-hydroxycamptothecin449.7TP53, AFP
7b 723449.5VIM, AFP, KRT7
8cytosine44 2410.5CDKN2A, AFP, H19
9aristolochic acid44 210.4TP53, VIM
10acnu449.4CDKN2A, TP53
11hpvs449.4CDKN2A, TP53
12folate449.3VIM, AFP, CDKN2A
13olomoucine44 1110.3CDKN2A, TP53
145-methylcytosine44 2410.3CDKN2A, TP53
15valine449.3VIM, AFP, CDKN2A
16aflatoxin b144 2410.2CDKN2A, TP53
17hematoxylin449.2KRT7, CDKN2A, VIM
18hmba449.2CDKN2A, TP53
19chloramphenicol44 2 1111.2VIM, AFP, CDKN2A
20vinblastine44 49 1111.2VIM, AFP, TP53
21bcnu449.1CDKN2A, TP53
22paclitaxel44 49 1111.1TP53, CDKN2A, AFP
23irinotecan44 49 1111.1AFP, CDKN2A, TP53
24o6-methylguanine449.0CDKN2A, TP53
25azathioprine44 49 2 1112.0VIM, H19, AFP, CDKN2A
26agar449.0VIM, H19, AFP, CDKN2A
27temozolomide44 119.9TP53, CDKN2A, VIM
28roscovitine448.9VIM, CDKN2A, TP53
295fluorouracil448.9TP53, CDKN2A, AFP
30methotrexate44 49 1110.9KRT7, CDKN2A, AFP, VIM
31cytarabine44 49 1110.9TP53, CDKN2A, VIM
32thymidylate448.9VIM, CDKN2A, TP53
33iron44 249.8VIM, AFP, CDKN2A, KRT7
34testosterone44 59 11 2411.8VIM, AFP, CDKN2A, KRT7
35retinoid448.8TP53, KRT7, VIM
36paraffin448.8KRT7, CDH3, AFP, H19, VIM
37crcs448.7TP53, CDKN2A
38etoposide44 49 59 1111.7TP53, AFP, VIM
39vincristine44 49 1110.6TP53, CDKN2A, AFP, VIM
40adriamycin448.6VIM, AFP, CDKN2A, TP53
41doxorubicin44 49 1110.6TP53, CDKN2A, AFP, VIM
42actinomycin d448.6VIM, AFP, CDKN2A, TP53
43h2o2448.5TP53, CDKN2A, AFP, VIM
44oligonucleotide448.4VIM, AFP, CDKN2A, TP53
45arginine448.1VIM, CDKN2A, KRT7, TP53
46vegf448.1TP53, KRT7, CDKN2A, AFP, VIM
47progesterone44 59 28 11 2411.7VIM, AFP, CDKN2A, CDH3, KRT7, TP53
48retinoic acid44 248.7VIM, H19, AFP, CDKN2A, KRT7, TP53
495-aza-2deoxycytidine447.6VIM, H19, SNRPN, CDKN2A, KRT7, TP53

GO Terms for genes affiliated with Malignant Mixed Mullerian Tumor

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16Gene Ontology
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Cellular components related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear bodyGO:0166049.0TP53, CDKN2A

Biological processes related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell cycle arrestGO:0711589.0TP53, CDKN2A
2replicative senescenceGO:0903998.7TP53, CDKN2A

Molecular functions related to Malignant Mixed Mullerian Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:0973719.0TP53, CDKN2A

Products for genes affiliated with Malignant Mixed Mullerian Tumor

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Sources for Malignant Mixed Mullerian Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet