Malignant Peripheral Nerve Sheath Tumor malady

NIH Rare Diseases: A malignant peripheral nerve sheath tumor (MPNST) is a tumor that develops from nerve tissue.  The first symptom of MPNST is a lump or mass that increases in size, sometimes causing pain or a tingling sensation.  MPNST is considered an aggressive tumor because there is up to a 65% chance of the tumor regrowing after surgery (a recurrence), and approximately 40% chance of spreading to distant parts of the body (a metastasis), most commonly to the lung.  Treatment of MPNST begins with surgery to remove as much of the tumor as possible.  Radiation therapy may be used to decrease the chance of a recurrence.  Chemotherapy might be used if the whole tumor cannot be removed during surgery, or to treat a metastasis.  MPNSTs are quite rare, occurring in 0.001% of the general population.  Approximately 25-50% of MPNSTs are associated with a genetic condition known as neurofibromatosis type 1.³⁰

MalaCards: Malignant Peripheral Nerve Sheath Tumor, also known as MPNST, is related to neurofibromatosis and epithelioid malignant peripheral nerve sheath tumor. An important gene associated with Malignant Peripheral Nerve Sheath Tumor is NGFR (nerve growth factor receptor), and among its related pathways are Actin-Based Motility by Rho Family GTPases and ERK5 Signaling. The compounds lipid and testosterone have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, colon and lung, and related mouse phenotypes are cellular and growth/size.

Wikipedia: A malignant peripheral nerve sheath tumor (also known as \"Malignant schwannoma,\"...⁴⁴ more...

Aliases & Descriptions:

malignant peripheral nerve sheath tumor 6 30 8 43 mpnst 30 32 malignant peripheral nerve sheath tumor (morphologic abnormality) 6 malignant peripheral nerve sheath tumor (morphologic abnormality) 6

malignant peripheral nerve sheath tumor (disorder) 6 malignant neoplasm of the peripheral nerve sheath 6 malignant peripheral nerve sheath tumors 32 malignant neoplasms 43

Diseases related to malignant peripheral nerve sheath tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 913)

id	Related Disease	Score	Top Affiliating Genes
1	neurofibromatosis	36.9	KIT, S100B, MMP13, NGFR, NF1, NF2
2	epithelioid malignant peripheral nerve sheath tumor	36.5	CHGA, S100B, SMARCB1, NGFR, PRG2, CSF3
3	tongue cancer	33.4	VIM, BCL2, CDKN2A, CD44, TP53, TERT
4	synovial sarcoma	33.4	KIT, VIM, BCL2, MUC1, S100B, MMP13
5	plexiform neurofibroma	32.8	S100B, NF1, NF2
6	cellular schwannoma	32.7	VIM, S100A1, S100B, NF1, NF2
7	nasopharynx carcinoma	32.0	BCL2, JUN, CDKN2A, CDK4, MDM2, TP53
8	salivary gland cancer	31.5	KIT, MMP13, MET, ERBB2, EGFR, HGF
9	brain cancer	30.9	CD44, MDM2, EGF, EGFR
10	neurofibroma	30.5	KIT, VIM, MUC1, S100A1, S100B, CDKN2A
11	brain stem neoplasm	30.5	EGF, NES
12	ovarian cancer	30.4	CDK2, CDKN2B, CDKN2A, CDK4, CCND3
13	choroid plexus carcinoma	30.2	VIM, TP53, SMARCB1
14	cardia cancer	30.1	CDKN2A, CD44, MDM2, TP53
15	nervous system cancer	30.0	CDKN2B, NF1, NF2
16	pancreatic cancer	29.9	CHGA, MUC1, S100A6, CDK2, ITGB4, TERT
17	stomach carcinoma	29.9	CHGA, CDKN2A, CD44
18	neuropathy	29.3	NCAM1, VIM, MYOG, CHGA, JUN, MBP
19	pancreatic ductal carcinoma	29.0	MUC1, CDK2, CDKN2A, TP53, EGF, EGFR
20	breast cancer	29.0	BCL2, MMP13, MDM2, ERBB2, TP53, NF1
21	angiosarcoma	28.9	KIT, VIM, MYOG, MUC1, S100B, CDKN2A
22	rhabdoid cancer	28.4	VIM, SMARCB1, DES
23	liver cancer	28.2	BCL2, S100A6, CDKN2A, CDK4, MET, ERBB2
24	oropharyngeal cancer, adult	27.9	CDKN2A, TP53, EGFR
25	spiradenoma	27.9	S100A1, TP53, ACTC1
26	pulmonary blastoma	27.9	VIM, TP53, EGFR
27	kidney cancer	27.9	KIT, VIM, BCL2, MUC1, JUN, CDKN2A
28	cervix carcinoma	27.9	CDKN2A, CD44, MET, ERBB2, TP53
29	verrucous carcinoma	27.8	CDKN2A, CD44, MDM2, TP53, EGFR
30	letterer-siwe disease	27.8	NCAM1, KIT, S100A1, S100B, TP53, ACTC1
31	multiple endocrine neoplasia	27.5	CHGA, JUN, CDKN2B, CDKN2A, CDK4, NF1
32	non-hodgkin lymphoma	27.3	BCL2, CDKN2B, CD34, CD44, MDM2, CCND3
33	skin cancer	27.1	VIM, BCL2, JUN, CDK2, CDKN2A, CDK4
34	large cell carcinoma	26.8	CHGA, CDK2, CDK4, ERBB2, EGFR
35	adrenocortical tumor	26.8	CHGA, CDK2, CDKN2A, CDK4, MDM2, CALB2
36	cystadenocarcinoma	26.7	VIM, BCL2, MUC1, CALB2, TP53, ACTC1
37	thyroid cancer, anaplastic	26.7	MET, TP53, TERT, EGF
38	esophageal cancer	26.7	BCL2, CHFR, MUC1, S100A2, JUN, CDKN2B
39	angiomyolipoma	26.7	KIT, VIM, CHGA, MUC1, S100A1, S100B
40	mixed cell type cancer	26.6	VIM, ERBB2, TP53, DES
41	testicular cancer	26.3	MDM2, CCND3, TP53, TERC, NRAS, EGF
42	soft tissue sarcoma	26.0	KIT, VIM, MYOG, BMP2, BMP4, BCL2
43	acute lymphoblastic leukemia	25.8	KIT, BCL2, JUN, CDK2, CDKN2B, CDKN2A
44	urinary bladder cancer	25.8	CDK2, CDKN2B, CDKN2A, MDM2, ERBB2, TP53
45	rhabdomyosarcoma	25.8	NCAM1, VIM, MYOG, BMP4, KDM1A, BCL2
46	seminoma	25.8	KIT, VIM, BCL2, CDK2, CALB2, ETV4
47	myocardial infarction	25.7	BCL2, CHGA, LAMA3, S100A1, S100B, CDKN2B
48	glioblastoma	25.4	CDKN2B, CDKN2A, CDK4, CD44, MET, MDM2
49	anaplastic large cell lymphoma	25.1	KIT, BCL2, MUC1, JUN, CDK2, CDK4
50	laryngeal carcinoma	24.9	BCL2, MUC1, S100A1, S100B, CDK2, CDKN2A

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to malignant peripheral nerve sheath tumor:

²²

MGI Mouse Phenotypes related to malignant peripheral nerve sheath tumor:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	INF	, KIT, VIM, BMP2, BMP4, KDM1A
2	growth/size phenotype	MP:0005378	INF	, BMP2, BMP4, BMP5, BCL2, CHGA
3	immune system phenotype	MP:0005387	INF	VIM, SMARCB1, RPS6KB1, NF1, NF2, PDGFRA
4	hearing/vestibular/ear phenotype	MP:0005377	INF	EYA4, HMGA2, NGFR, NF1, NF2, EGFR
5	vision/eye phenotype	MP:0005391	INF	JUN, CDK2, CDKN2A, CDK4, CD44, ITGB4
6	skeleton phenotype	MP:0005390	INF	ETV4, ERBB2, TP53, TERC, TERT, SRC
7	mortality/aging	MP:0010768	INF	, TP53, DACH1, NRG1, SMARCB1, NGFR
8	nervous system phenotype	MP:0003631	INF	TERC, TERT, DACH1, SRC, NRG1, SMARCB1
9	homeostasis/metabolism phenotype	MP:0005376	INF	TERT, MYH11, HGFAC, DACH1, NRAS, NRG1
10	reproductive system phenotype	MP:0005389	8.7	CD44, EYA1, ETV4, HMGA1, HMGA2, ERBB2
11	liver/biliary system phenotype	MP:0005370	8.6	EGFR, NF2, NF1, NGFR, SMARCB1, TP53
12	renal/urinary system phenotype	MP:0005367	6.6	TP53, NGFR, NF1, NF2, PDGFRA, PDGFRB
13	digestive/alimentary phenotype	MP:0005381	5.9	BMP4, BMP5, BCL2, MUC1, LAMA3, CDKN2A
14	cardiovascular system phenotype	MP:0005385	3.8	CDK2, NGFR, NF1, PDGFRA, PDGFRB, EGFR
15	normal phenotype	MP:0002873	INF	TERT, NRAS, NF1, PDGFRA, SOX10,
16	integument phenotype	MP:0010771	INF	KIT, , BCL2, MUC1, LAMA3, S100B
17	tumorigenesis	MP:0002006	INF	ETV4, HMGA1, ERBB2, TP53, TERC, TERT
18	behavior/neurological phenotype	MP:0005386	INF	, KIT, VIM, , BMP4, BMP5
19	embryogenesis phenotype	MP:0005380	INF	KIT, VIM, , BMP5, KDM1A, CDK4
20	pigmentation phenotype	MP:0001186	INF	SRC, NF1, PDGFRA, EGFR, SOX10, TERC
21	endocrine/exocrine gland phenotype	MP:0005379	INF	HMGA2, DACH1, NRG1, NF1, NF2, SOX10
22	respiratory system phenotype	MP:0005388	INF	MYH11, SIX1, PRG2, NF2, , BMP5
23	muscle phenotype	MP:0005369	INF	BMP4, BCL2, S100A1, CDK2, CDKN2A, CDK4
24	craniofacial phenotype	MP:0005382	INF	SIX1, PDGFRB, PDGFRA, NF2, NF1, HMGA2
25	limbs/digits/tail phenotype	MP:0005371	INF	MDM2, ETV4, HMGA2, ERBB2, TP53, TERC
26	hematopoietic system phenotype	MP:0005397	INF	SMARCB1, NF1, PDGFRA, PRG2, CSF3, SIX1
27	no phenotypic analysis	MP:0003012	INF	TP53, HMGA1, ETV4, MET, , CD44

Articles related to malignant peripheral nerve sheath tumor:

(show top 50)    (show all 70)

id	Title	Authors	Year	Affiliating Genes
1	Activated MET is a molecular prognosticator and poten tial therapeutic target for malignant peripheral nerve sheath tumors. (21540237)	Torres K.E.... Lev D.	2011	MET
2	Prognostic significance of p14ARF, p15INK4b, and p16I NK4a inactivation in malignant peripheral nerve sheath tumors. (21262917)	Endo M.... Oda Y.	2011	CDKN2A, CDKN2B
3	Lysine-specific demethylase 1 is highly expressed in solitary fibrous tumors, synovial sarcomas, rhabdomyosarcomas, desmoplastic sma ll round cell tumors, and malignant peripheral nerve sheath tumors. (21531005)	Schildhaus H.U.... Kirfel J.	2011	KDM1A
4	Malignant peripheral nerve sheath tumor of intracrani al nerve: a case series review. (20399579)	Ziadi A.... Saliba I.	2010	NF2
5	The role of neurofibromin in N-Ras mediated AP-1 regu lation in malignant peripheral nerve sheath tumors. (20680410)	Kraniak J.M.... Tainsky M.A.	2010	JUN, NRAS, NF1
6	TP53 mutation analysis of malignant peripheral nerve sheath tumors. (20010306)	Verdijk R.M.... Kros J.M.	2010	TP53
7	Malignant peripheral nerve sheath tumor of the uterin e cervix expressing both S-100 protein and HMB-45. (20025639)	Kim N.R.... Ha S.Y.	2009	S100B
8	Molecular characterization of permanent cell lines from primary, metastatic and recurrent malignant peripheral nerve sheath tumors (MPNST) with underlying neurofibromatosis-1. (19414372)	Fang Y.... Jhanwar S.C.	2009	NF1
9	Neuregulin-1 beta and neuregulin-1 alpha differential ly affect the migration and invasion of malignant peripheral nerve sheath tumor cells. (19306381)	Eckert J.M.... Carroll S.L.	2009	NRG1
10	Actin expression in neural crest cell-derived tumors including schwannomas, malignant peripheral nerve sheath tumors, neurofibromas and melanocytic tumors. (19154261)	Dundr P.... TvrdA-k D.	2009	MYH11
11	Identification of p53 as a strong predictor of surviv al for patients with malignant peripheral nerve sheath tumors. (19182148)	Brekke H.R.... Lothe R.A.	2009	TP53
12	EGFR and erbB2 in malignant peripheral nerve sheath tumors and implications for targeted therapy. (18650488)	Holtkamp N.... von Deimling A.	2008	ERBB2, EGFR, CDKN2A
13	High-resolution DNA copy number profiling of malignant peripheral nerve sheath tumors using targeted microarray-based comparative genomic hybridization. (18281533)	Mantripragada K.K.... Upadhyaya M.	2008	PDGFRA, MMP13, RPS6KB1
14	DNA copy number changes in high-grade malignant peripheral nerve sheath tumors by array CGH. (18522746)	Kresse S.H.... Meza-Zepeda L.A.	2008	TOP2A, LOXL2, ETV4
15	Differential expression of S100 protein subtypes in malignant melanoma, and benign and malignant peripheral nerve sheath tumors. (18547346)	Nonaka D.... Rubin B.P.	2008	S100B, S100A2, S100A6
16	Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs). (17960768)	Upadhyaya M.... Mautner V.	2008	NF1
17	Epidermal growth factor receptor expression and mutational analysis in synovial sarcomas and malignant peripheral nerve sheath tumors. (18448562)	Tawbi H.... Baker L.H.	2008	EGFR
18	Imatinib mesylate inhibits cell invasion of malignant peripheral nerve sheath tumor induced by platelet-derived growth factor-BB. (17558420)	Aoki M.... Iwasaki H.	2007	PDGFRA, PDGFRB
19	Nestin expression as a new marker in malignant peripheral nerve sheath tumors. (17300669)	Shimada S.... Illei P.B.	2007	NES
20	MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors. (17786186)	Holtkamp N.... von Deimling A.	2007	TP53, MMP13
21	Malignant peripheral nerve sheath tumor of the breast: case report. (18154670)	Dhingra K.K.... Khurana N.	2007	VIM
22	Primary pulmonary malignant peripheral nerve sheath tumor: a case report. (17910355)	Tashiro T.... Sano N.	2007	S100B
23	Aberrant expression of CHFR in malignant peripheral nerve sheath tumors. (16554732)	Kobayashi C.... Tsuneyoshi M.	2006	CHFR
24	Chromosomal imbalances in malignant peripheral nerve sheath tumor detected by metaphase and microarray comparative genomic hybridization. (16391845)	Nakagawa Y.... Ozaki T.	2006	LAMA3
25	Cluster analysis of immunohistochemical profiles in synovial sarcoma, malignant peripheral nerve sheath tumor, and Ewing sarcoma. (16528378)	Olsen S.H.... Lucas D.R.	2006	BCL2, MUC1, NGFR
26	Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. (16510576)	Miller S.J.... Ratner N.	2006	NGFR, SOX10
27	HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor. (16056249)	Hui P.... Tallini G.	2005	HMGA1, HMGA2
28	Activation of the neuregulin-1/ErbB signaling pathway promotes the proliferation of neoplastic Schwann cells in human malignant peripheral nerve sheath tumors. (15897877)	Stonecypher M.S.... Carroll S.L.	2005	EGFR, NRG1
29	Expression patterns of cell cycle components in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. (15715087)	Agesen T.H.... Lothe R.A.	2005	CDK4, CDK2, CCND3
30	Schwann cell lines derived from malignant peripheral nerve sheath tumors respond abnormally to platelet-derived growth factor-BB. (15602756)	Dang I.... DeVries G.H.	2005	NF1
31	Epithelioid malignant peripheral nerve sheath tumor. Report of a case with inflammatory infiltration. (15991844)	Matsuda Y.... Imaida K.	2005	S100B, CSF3, CHGA
32	Superficial malignant peripheral nerve sheath tumor: a rare and challenging diagnosis. (16203275)	Allison K.H.... Rubin B.P.	2005	DES, ACTC1
33	Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors. (14673600)	Holtkamp N.... von Deimling A.	2004	PDGFRA, MMP13
34	Immunohistochemical diagnosis of a rare case of epithelioid malignant peripheral nerve sheath tumor with multiple metastases. (15592781)	Tsuchiya D.... Yamashita H.	2004	NGFR
35	Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. (14508393)	Woodruff J.M.... Antonescu C.R.	2003	S100B
36	Malignant peripheral nerve sheath tumor cell invasion is facilitated by Src and aberrant CD44 expression. (12730955)	Su W.... Sherman L.S.	2003	SRC, CD44, NF1
37	Cytogenetic characterization of three malignant peripheral nerve sheath tumors. (12810251)	Frank D.... FA1zesi L.	2003	NF1, NF2
38	Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. (12152785)	Perry A.... Gutmann D.H.	2002	EGFR, CDKN2A, NF1
39	NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors. (11438454)	Perry A.... Gutmann D.H.	2001	S100B
40	Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases. (11145248)	McMenamin M.E.... Fletcher C.D.	2001	S100B
41	Transcriptional mRNA of bone morphogenetic proteins 2, 3, 4, and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. (11411255)	Tang C.S.... Fang Y.R.	2001	BMP4, BMP2
42	Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors. (11406645)	Birindelli S.... Pilotti S.	2001	MDM2, CDKN2A, NF1
43	Expression of protein gene product 9.5 in epithelioid and conventional malignant peripheral nerve sheath tumors. (11570907)	Hoang M.P.... Albores-Saavedra J.	2001	MUC1, ACTC1
44	Chromosome band 9p21 is frequently altered in malignant peripheral nerve sheath tumors: studies of CDKN2A and other genes of the pRB pathway. (10469453)	Berner J.M.... Lothe R.A.	1999	CDK4, MDM2, CDKN2A
45	Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor. (10549251)	Smith T.A.... Goldblum J.R.	1999	MUC1
46	Metastatic malignant melanoma resembling malignant peripheral nerve sheath tumor: report of 16 cases. (10584703)	King R.... Rosai J.	1999	S100B
47	Hepatocyte growth factor and c-MET in benign and malignant peripheral nerve sheath tumors. (9308731)	Rao U.N.... Michalopoulos G.K.	1997	MET
48	Epithelioid variant of malignant peripheral nerve sheath tumor (9388863)	Li Y.... Li G.	1996	VIM
49	Cytogenetic analysis of soft tissue sarcomas. Recurrent chromosome abnormalities in malignant peripheral nerve sheath tumors (MPNST). (7828144)	Jhanwar S.C.... Woodruff J.M.	1994	NF2
50	Plexiform malignant peripheral nerve sheath tumor(MPNST) in infancy and childhood--a case report. (7786443)	Nam E.S.... Kim I.N.	1994	MBP

Genes related to malignant peripheral nerve sheath tumor according to GeneCards:

(show top 50)    (show all 64)

id	Symbol	Description	Score	GeneCards Section Context
1	NGFR	nerve growth factor receptor	11.1	Publications
2	S100B	S100 calcium binding protein B	11.1	Publications
3	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.1	Publications
4	SOX10	SRY (sex determining region Y)-box 10	11.1	Publications
5	NF2	neurofibromin 2 (merlin)	11.1	Publications
6	NES	nestin	11.1	Publications
7	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.1	Publications
8	S100A1	S100 calcium binding protein A1	11.1	Publications
9	S100A6	S100 calcium binding protein A6	11.1	Publications
10	TOP2A	topoisomerase (DNA) II alpha 170kDa	11.1	Publications
11	NF1	neurofibromin 1	11.1	Publications
12	BMP2	bone morphogenetic protein 2	11.1	Publications
13	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.1	Publications
14	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.1	Publications
15	CHGA	chromogranin A (parathyroid secretory protein 1)	11.1	Publications
16	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.1	Publications
17	CD44	CD44 molecule (Indian blood group)	11.1	Publications
18	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.1	Publications
19	VIM	vimentin	11.1	Publications
20	TERT	telomerase reverse transcriptase	11.1	Publications
21	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.1	Publications
22	CSF3	colony stimulating factor 3 (granulocyte)	11.1	Publications
23	NRG1	neuregulin 1	11.1	Publications
24	EGFR	epidermal growth factor receptor	11.1	Publications
25	SIX1	SIX homeobox 1	11.0	Publications
26	HGFAC	HGF activator	11.0	Publications
27	ETV4	ets variant 4	11.0	Publications
28	S100A2	S100 calcium binding protein A2	11.0	Publications
29	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
30	HMGA1	high mobility group AT-hook 1	11.0	Publications
31	BMP3	bone morphogenetic protein 3	11.0	Publications
32	CHFR	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	11.0	Publications
33	B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	11.0	Publications
34	TERC	telomerase RNA component	11.0	Publications
35	ITGB4	integrin, beta 4	11.0	Publications
36	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	11.0	Publications
37	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
38	BMP4	bone morphogenetic protein 4	11.0	Publications
39	BMP5	bone morphogenetic protein 5	11.0	Publications
40	KDM1A	lysine (K)-specific demethylase 1A	11.0	Publications
41	EYA1	eyes absent homolog 1 (Drosophila)	11.0	Publications
42	HMGA2	high mobility group AT-hook 2	11.0	Publications
43	LOXL2	lysyl oxidase-like 2	11.0	Publications
44	MUC1	mucin 1, cell surface associated	11.0	Publications
45	LAMA3	laminin, alpha 3	11.0	Publications
46	EYA2	eyes absent homolog 2 (Drosophila)	11.0	Publications
47	DES	desmin	11.0	Publications
48	CCND3	cyclin D3	11.0	Publications
49	EYA4	eyes absent homolog 4 (Drosophila)	11.0	Publications
50	CDK4	cyclin-dependent kinase 4	11.0	Publications

Pathways related to malignant peripheral nerve sheath tumor according to GeneDecks:

(show top 50)    (show all 150)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.1	NRG1, BMP5, NGFR, BMP4, ITGB4, BMP3
2	ERK5 Signaling36	8.9	KIT, BMP2, BMP3, BMP4, BMP5, MET
3	Endothelin-1 Signaling Pathway36	8.7	KIT, CSF3, EGFR, BMP2, BMP3, BMP4
4	Breast Cancer Regulation by Stathmin136	8.6	HGF, BMP2, BMP3, BMP4, BMP5, ERBB2
5	14-3-3 Induced Intracellular Signaling36	8.6	JUN, ERBB2, SRC, NRAS, NRG1, PDGFRA
6	Akt Signaling36	8.5	HGF, PDGFRB, PDGFRA, NGFR, NRG1, NRAS
7	Renin-Angiotensin Pathway36	8.4	NGFR, HGF, EGFR, PDGFRA, NRG1, NRAS
8	eIF2 Pathway36	8.3	MET, BMP5, BMP3, KIT, BMP4, NRG1
9	Nuclear Receptor Activation by Vitamin-A36	8.3	BMP3, HGF, EGFR, EGF, NGFR, PDGFRB
10	PPAR Pathway36	8.2	HGF, EGFR, EGF, KIT, BMP2, BMP3
11	Glioblastoma Multiforme36	8.1	CDK2, CDK4, MDM2, TP53, SRC, NRAS
12	Ras Pathway36	8.1	EGF, EGFR, NRG1, NRAS, KIT, BMP2
13	Telomerase Components in Cell Signaling36	8.1	KIT, BMP2, BMP3, BMP4, BMP5, MET
14	p70S6K Signaling36	8.0	BMP5, BMP4, BMP3, BMP2, NRG1, NRAS
15	Activation of PKC through GPCR36	8.0	BMP2, EGFR, BMP3, BMP4, BMP5, NRG1
16	Rac1 Pathway36	8.0	BMP3, BMP4, BMP5, JUN, ITGB4, MET
17	Bladder cancer20	7.9	EGF, NRAS, TP53, ERBB2, MDM2, CDK4
18	PAK Pathway36	7.9	KIT, BMP2, BMP4, PDGFRA, NGFR, NRG1
19	Paxillin Interactions36	7.9	KIT, BMP2, BMP3, BMP4, ITGB4, MET
20	DHA Signaling36	7.9	EGFR, EGF, PDGFRB, MET, KIT, BMP3
21	Glioma20	7.9	CDK4, MDM2, EGF, PDGFRB, PDGFRA, NRAS
22	ERK Signaling36	7.7	PDGFRA, PDGFRB, EGF, EGFR, PRG2, CSF3
23	Apoptotic Pathways in Synovial Fibroblasts36	7.7	KIT, BMP2, BMP3, BMP4, BMP5, MET
24	Nanog in Mammalian ESC Pluripotency36	7.6	PDGFRB, KIT, BMP2, BMP3, BMP4, BMP5
25	Phospholipase-C Pathway36	7.6	KIT, HGF, PRG2, EGFR, BMP2, BMP3
26	Rap1 Pathway36	7.6	EGFR, EGF, BMP5, BMP4, BMP3, ERBB2
27	JNK Pathway36	7.5	JUN, BCL2, BMP5, BMP4, BMP3, BMP2
28	TGF-Beta Pathway36	7.4	EGF, NRAS, MET, JUN, BCL2, EGFR
29	GSK3 Signaling36	7.4	BMP2, NRAS, HGF, EGFR, BMP3, BMP4
30	NFAT in Immune Response36	7.4	KIT, BMP5, JUN, ERBB2, NRG1, MET
31	ILK Signaling36	7.3	NRG1, ERBB2, MET, ITGB4, JUN, LAMA3
32	Intracellular Calcium Signaling36	7.1	EGFR, BMP2, SRC, HGF, PDGFRA, BMP3
33	Prostate cancer20	7.1	NRAS, PDGFRA, ERBB2, TP53, CDK2, PDGFRB
34	p53 Mediated Apoptosis36	7.1	BMP3, BMP4, BMP5, BCL2, MET, MDM2
35	Antioxidant Action of Vitamin-C36	7.0	BMP3, PDGFRB, MYH11, CSF3, EGFR, EGF
36	Tec Kinases Signaling36	7.0	BMP5, HGF, BMP3, BMP2, BMP4, BCL2
37	Cellular Apoptosis Pathway36	7.0	HGF, BMP2, BMP3, BMP4, BMP5, BCL2
38	Mitochondrial Apoptosis36	7.0	KIT, BMP2, BMP3, BMP4, BMP5, BCL2
39	GPCR Pathway36	7.0	KIT, NRG1, PDGFRA, PDGFRB, BMP2, BMP3
40	PTEN Pathway36	6.8	PDGFRA, PDGFRB, EGF, EGFR, PRG2, HGF
41	JAK-STAT Pathway36	6.8	PDGFRB, EGF, BMP5, BCL2, JUN, MET
42	Focal adhesion20	6.7	SRC, PDGFRA, PDGFRB, EGF, ERBB2, CCND3
43	Estrogen Pathway36	6.6	HGF, EGFR, EGF, KIT, BMP2, BMP3
44	Rho Family GTPases36	6.3	KIT, VIM, BMP2, BMP3, BMP4, EGFR
45	Molecular Mechanisms of Cancer36	5.9	BMP2, BMP3, BMP4, BCL2, JUN, CDK2
46	p38 Signaling36	5.9	KIT, BMP2, BMP3, BMP4, BMP5, BCL2
47	MAPK Signaling36	5.3	HGF, PRG2, EGFR, EGF, PDGFRB, PDGFRA
48	Pancreatic Adenocarcinoma36	5.1	KIT, BMP2, BMP3, PDGFRB, EGF, EGFR
49	Pathways in cancer20	INF	PDGFRA, NRAS, TP53, ERBB2, MDM2, BCL2
50	Melanoma20	INF	TP53, MDM2, MET, , CDK4, CDKN2A

Compounds related to malignant peripheral nerve sheath tumor according to GeneDecks:

(show top 50)    (show all 234)

id	Compound	Score	Top Affiliating Genes
1	lipid32	INF	, VIM, , BMP2, CHGA, MUC1
2	testosterone32 9 18 9	INF	, KIT, VIM, , BMP2, KDM1A
3	retinoic acid32 42 18	INF	, KIT, , BMP2, BMP4, CHGA
4	estrogen32	INF	, BMP2, BMP4, CHGA, S100A1, S100A6
5	butyrate32	INF	VIM, , BCL2, MUC1, JUN, CDK2
6	progesterone32 42 9 18 9	INF	, KIT, VIM, BMP2, BMP4, BCL2
7	paraffin32	INF	, KIT, VIM, , BCL2, CHGA
8	serine32	INF	, KIT, VIM, , BMP2, BMP4
9	12-o-tetradecanoylphorbol 13-acetate32	INF	, , , CDK4, CD44, MMP13
10	thymidine32 18	INF	KIT, BMP2, BMP4, MUC1, S100B, JUN
11	calcium32 9 18 9	INF	KIT, , BMP2, BMP3, BMP4, MUC1
12	bromodeoxyuridine32	INF	, VIM, , BMP4, CHGA, S100B
13	oxygen32 18	INF	, BMP2, KDM1A, BCL2, JUN, CDK2
14	threonine32	10.5	BMP2, CDKN2B, NRG1, NF2
15	egcg32	10.0	CDK2, PDGFRB
16	trastuzumab32 34 9 9	11.0	KIT, MUC1, CDK2, CDK4, MDM2, ERBB2
17	cytarabine32 34 9 9	10.3	KIT, VIM, BCL2, MUC1, JUN, CDK2
18	gefitinib32 34 9 9	10.3	KIT, VIM, CDK2, CDK4, MET, MDM2
19	imatinib32 34 9 9	10.2	KIT, BCL2, S100B, CDK2, MDM2, CCND3
20	etoposide32 42 9 9	10.2	BCL2, CHGA, S100B, JUN, CDK2, CD44
21	flavopiridol32 9 9	9.1	KIT, BCL2, CDK2, CDKN2A, CDK4, MDM2
22	adriamycin32	7.0	VIM, BCL2, MUC1, CDKN2A, CD44, MET
23	geldanamycin32 9 9	8.5	JUN, CDK2, CDK4, MET, MDM2, ERBB2
24	wortmannin32 42	7.3	VIM, BMP2, BCL2, S100B, JUN, MET
25	genistein32 9 18 9	9.0	VIM, BMP2, BCL2, JUN, CDK2, CDKN2A
26	actinomycin d32	5.8	KIT, VIM, BMP2, BMP4, BCL2, MUC1
27	5fluorouracil32	5.8	KIT, BCL2, MUC1, CDK2, CDKN2A, CDK4
28	cycloheximide32	5.1	KIT, VIM, BMP2, BMP4, BCL2, CHGA
29	cisplatin32 34 9 9	7.2	BCL2, CHGA, MUC1, CDK2, CDKN2A, CDK4
30	cyclic amp32 18	INF	CHGA, JUN, CDKN2A, CDK4, MMP13,
31	doxorubicin32 34 9 9	INF	, KIT, VIM, CDK2, CDK4, CD44
32	heparin32 9 18 9	INF	, VIM, BMP4, B3GAT1, CDK2, MMP13
33	agar32	INF	VIM, MUC1, JUN, CDK2, CDKN2A,
34	tamoxifen32 34 9 9	INF	VIM, BCL2, CHGA, MUC1, JUN, CDK2
35	pd 98,05932	INF	KIT, , BMP2, BMP4, BCL2, JUN
36	matrigel32	INF	, VIM, BMP2, BMP4, CHGA, MUC1
37	arginine32	INF	BMP2, CHGA, B3GAT1, S100B, CDK2, CDK4
38	steroid32	INF	KIT, , BMP2, BMP4, CHGA, S100A6
39	dexamethasone32 42 34 9 9	INF	, VIM, BMP2, BMP3, BMP4, BCL2
40	rapamycin32 42	INF	KIT, VIM, , BMP2, BMP4, CDK2
41	paclitaxel32 34 9 9	INF	KIT, VIM, BCL2, CHFR, CHGA, S100B
42	cysteine32	INF	, BMP4, MUC1, S100A1, S100A2, S100A6
43	hematoxylin32	INF	, KIT, VIM, CHGA, MUC1, S100A1
44	vegf32	INF	, KIT, , BMP2, BMP4, BCL2
45	tyrosine32	INF	, KIT, , BMP2, BMP4, CHGA
46	acetylcholine32 9 18 9	INF	, VIM, , CHGA, S100A1, S100B
47	ly29400232	INF	, JUN, CD44, CCND3, HMGA1, ERBB2
48	nitric oxide32 9 18 9	INF	, KIT, , BMP2, BMP4, CHGA
49	phosphatidylinositol32	INF	, KIT, BMP4, BCL2, CDK2, CD44
50	oligonucleotide32	INF	KIT, VIM, , BMP2, BMP4, BCL2

Cellular components related to malignant peripheral nerve sheath tumor according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	NRG1, DACH1, TERT, TP53, , EYA4
2	extracellular region	GO:005576	INF	HGF, PRG2, EGF, NGFR, NRG1,
3	senescence-associated heterochromatin focus	GO:035985	10.2	CDKN2A, HMGA1, HMGA2
4	membrane-bounded vesicle	GO:031988	10.2	BMP5, BMP4, BMP3, BMP2
5	nuclear chromosome	GO:000228	9.9	TOP2A, SMARCB1, HMGA2, JUN
6	cyclin-dependent protein kinase holoenzyme complex	GO:000307	9.4	CCND3, CDK4, CDK2
7	nucleus	GO:005634	INF	SIX1, HMGA2, ERBB2, TP53, DACH1, SRC
8	transcription factor complex	GO:005667	INF	SIX1, DACH1, HMGA1, CDK4, CDK2, JUN
9	protein complex	GO:043234	INF	TOP2A, TP53, MDM2, , CDKN2A, S100A1
10	nucleoplasm	GO:005654	INF	TOP2A, NGFR, SMARCB1, TERT, TP53, HMGA1
11	extracellular space	GO:005615	INF	NRG1, EGF, EGFR, CSF3, HGF, HGFAC

Biological processes related to malignant peripheral nerve sheath tumor according to GeneDecks:

(show top 50)    (show all 55)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	EYA1, HMGA2, TP53, SMARCB1, TOP2A, SOX10
2	negative regulation of cell-matrix adhesion	GO:001953	10.6	NF2, NF1, CDKN2A
3	senescence-associated heterochromatin focus assembly	GO:035986	10.5	CDKN2A, HMGA1, HMGA2
4	positive regulation of cellular senescence	GO:2000774	10.5	CDKN2A, HMGA1, HMGA2
5	stem cell differentiation	GO:048863	10.5	SOX10, HMGA2, ETV4, KIT
6	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO:043518	10.4	MDM2, CD44, KDM1A
7	positive regulation of phospholipase C activity	GO:010863	10.4	KIT, PDGFRA, PDGFRB
8	activation of MAPKK activity	GO:000186	10.4	BMP4, NRAS
9	cardiac myofibril assembly	GO:055003	10.4	ACTC1, PDGFRB, PDGFRA
10	aorta morphogenesis	GO:035909	10.3	SIX1, PDGFRB, EYA1
11	smooth muscle tissue development	GO:048745	10.3	PDGFRB, NF1, BMP4
12	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.2	PDGFRB, PDGFRA, CD44, BMP4, BMP2
13	lymphoid progenitor cell differentiation	GO:002320	10.1	KIT, BMP4, BCL2
14	positive regulation of fibroblast proliferation	GO:048146	10.1	EGFR, PDGFRA, NGFR, CDK4, JUN, S100A6
15	positive regulation of DNA replication	GO:045740	10.0	EGFR, PDGFRA, MET, JUN
16	epithelial to mesenchymal transition	GO:001837	10.0	HGF, HMGA2, LOXL2, BMP2
17	cell chemotaxis	GO:060326	10.0	HGF, PDGFRB, PDGFRA, KIT
18	response to mechanical stimulus	GO:009612	10.0	RPS6KB1, JUN, BMP4, BMP2
19	SMAD protein signal transduction	GO:060395	9.9	JUN, BMP4, BMP2
20	positive regulation of endothelial cell proliferation	GO:001938	9.9	NF1, JUN, BMP4, BMP2
21	branching involved in ureteric bud morphogenesis	GO:001658	9.9	SIX1, EYA1, CD44, BCL2, BMP4, BMP2
22	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.8	HGF, PDGFRB, PDGFRA, KIT
23	replicative senescence	GO:090399	9.8	TERT, TP53, CDKN2A
24	positive regulation of smooth muscle cell proliferation	GO:048661	9.8	PDGFRB, RPS6KB1, JUN, BMP4
25	positive regulation of epithelial cell proliferation	GO:050679	9.7	EGFR, ERBB2, EYA1, BMP5, BMP4
26	digestive tract morphogenesis	GO:048546	9.7	SOX10, EGFR, BCL2
27	positive regulation of smooth muscle cell migration	GO:014911	9.6	BCL2, RPS6KB1, PDGFRB
28	peptidyl-tyrosine phosphorylation	GO:018108	9.6	EGF, PDGFRB, PDGFRA, SRC, KIT
29	phosphatidylinositol-mediated signaling	GO:048015	9.6	TOP2A, PDGFRB, PDGFRA, RPS6KB1, ERBB2, MDM2
30	positive regulation of cell cycle arrest	GO:071158	9.5	TP53, HMGA2, CDKN2A
31	response to wounding	GO:009611	9.5	RPS6KB1, MET, ITGB4, NGFR
32	protein autophosphorylation	GO:046777	9.3	EGFR, PDGFRB, PDGFRA, ERBB2, MET, KIT
33	positive regulation of MAP kinase activity	GO:043406	9.3	EGFR, EGF, PDGFRB, ERBB2
34	positive regulation of apoptotic process	GO:043065	9.3	TOP2A, NF1, TP53, HMGA2, BMP4, BMP2
35	central nervous system development	GO:007417	9.3	NES, NGFR, TP53, MBP, S100B
36	Ras protein signal transduction	GO:007265	9.1	NF1, NRAS, SRC, TP53, CDKN2A, CDK2
37	epidermal growth factor receptor signaling pathway	GO:007173	9.0	EGFR, EGF, NRAS, SRC, ERBB2, MDM2
38	negative regulation of cell proliferation	GO:008285	9.0	NF2, TP53, HMGA1, CDKN2A, CDKN2B, JUN
39	positive regulation of cell proliferation	GO:008284	9.0	PDGFRB, EGF, EGFR, CSF3, PDGFRA, NRAS
40	negative regulation of transcription, DNA-dependent	GO:045892	8.7	NRG1, TP53, HMGA2, HMGA1, LOXL2, MDM2
41	negative regulation of apoptotic process	GO:043066	8.2	BMP4, NES, SOX10, EGFR, RPS6KB1, TP53
42	response to drug	GO:042493	INF	NES, TOP2A, ACTC1, RPS6KB1, , MET
43	melanocyte differentiation	GO:030318	INF	SOX10, , BCL2, KIT
44	axon guidance	GO:007411	INF	MYH11, EGFR, NGFR, NRAS, SRC, ERBB2
45	aging	GO:007568	INF	TOP2A, RPS6KB1, LOXL2, , JUN
46	positive regulation of gene expression	GO:010628	INF	HMGA2, MET, CD44, , BMP2, KIT
47	cellular response to growth factor stimulus	GO:071363	INF	RPS6KB1, MET, BMP4, BMP2,
48	cell proliferation	GO:008283	INF	EGFR, NRG1, DACH1, TP53, ERBB2, MET
49	positive regulation of transcription, DNA-dependent	GO:045893	INF	SIX1, EGF, TP53, HMGA2, HMGA1, ETV4
50	ossification	GO:001503	INF	EGFR, BCL2, BMP5, BMP3,

Molecular functions related to malignant peripheral nerve sheath tumor according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	HGF, SMARCB1, NRG1, SRC, DACH1, TERT
2	S100 protein binding	GO:044548	10.4	S100B, S100A6, S100A1
3	BMP receptor binding	GO:070700	10.3	BMP5, BMP4, BMP3, BMP2
4	p53 binding	GO:002039	10.1	SMARCB1, MDM2, CDKN2A, MUC1, KDM1A
5	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.6	EGFR, PDGFRA, ERBB2, KIT
6	receptor signaling protein tyrosine kinase activity	GO:004716	9.6	KIT, ERBB2, EGFR
7	cytokine activity	GO:005125	9.5	CSF3, NRG1, BMP5, BMP4, BMP3, BMP2
8	enzyme binding	GO:019899	9.1	CSF3, TOP2A, EGFR, TP53, HMGA1, MDM2
9	protein homodimerization activity	GO:042803	9.1	TOP2A, PDGFRA, TERT, JUN, S100B, S100A6
10	growth factor activity	GO:008083	9.1	HGF, CSF3, EGF, NRG1, BMP5, BMP4
11	protein tyrosine kinase activity	GO:004713	9.0	EGFR, PDGFRB, SRC, ERBB2, MET, KIT
12	protease binding	GO:002020	8.6	KIT, BCL2, MBP, TP53
13	identical protein binding	GO:042802	8.3	SOX10, EGFR, TP53, ERBB2, MDM2, S100B
14	transcription factor binding	GO:008134	INF	TP53, HMGA2, HMGA1, , CDKN2A, JUN
15	protein heterodimerization activity	GO:046982	INF	HGF, TOP2A, EGFR, TP53, ERBB2, MET