|
MPNST
MCID: MLG077
|
Malignant Peripheral Nerve Sheath Tumor (MPNST) malady |
|
Sources: 39NIH Rare Diseases, 59Wikipedia, 29MalaCards See all sources Fully expand this MalaCard Export this MalaCard |
NIH Rare Diseases:39 A malignant peripheral nerve sheath tumor (mpnst) is a tumor that develops from nerve tissue. the first symptom of mpnst is a lump or mass that increases in size, sometimes causing pain or a tingling sensation. mpnst is considered an aggressive tumor because there is up to a 65% chance of the tumor regrowing after surgery (a recurrence), and approximately 40% chance of spreading to distant parts of the body (a metastasis), most commonly to the lung. treatment of mpnst begins with surgery to remove as much of the tumor as possible. radiation therapy may be used to decrease the chance of a recurrence. chemotherapy might be used if the whole tumor cannot be removed during surgery, or to treat a metastasis. mpnsts are quite rare, occurring in 0.001% of the general population. approximately 25-50% of mpnsts are associated with a genetic condition known as neurofibromatosis type 1.
MalaCards: Malignant Peripheral Nerve Sheath Tumor, also known as MPNST, is related to neurofibromatosis and synovial sarcoma. An important gene associated with Malignant Peripheral Nerve Sheath Tumor is S100B (S100 calcium binding protein B), and among its related pathways are Pathways in cancer and PIP3 activates AKT signaling. The compounds dexamethasone and threonine have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, smooth muscle and colon, and related mouse phenotypes are embryogenesis and pigmentation. Wikipedia:59 A malignant peripheral nerve sheath tumor (also known as \"Malignant schwannoma,\"... more... |
|
Sources: 8Disease Ontology, 39NIH Rare Diseases, 10DISEASES, 41Novoseek, 45Orphanet, 56UMLS, 52SNOMED-CT, 31MeSH, 36NCIt See all sources |
|
|
|
Sources: 5CenterWatch, 38NIH Clinical Center, 6ClinicalTrials, 56UMLS, 37NDF-RT See all sources |
Approved drugs:Search CenterWatch for malignant peripheral nerve sheath tumor Drug clinical trials:Search ClinicalTrials for malignant peripheral nerve sheath tumor Search NIH Clinical Center for malignant peripheral nerve sheath tumor Search CenterWatch for malignant peripheral nerve sheath tumor |
|
|
|
Sources: 29MalaCards See all sources |
MalaCards organs/tissues related to malignant peripheral nerve sheath tumor:29Smooth muscle, Colon, Lung, Breast, Cervix, T cells
|
|
Sources: 33MGI, 26inGenious Targeting Laboratory See all sources |
MGI Mouse Phenotypes related to malignant peripheral nerve sheath tumor:33 (show all 25)
|
|
Sources: 47PubMed See all sources |
Articles related to malignant peripheral nerve sheath tumor:(show top 50) (show all 73)
|
|
Sources: 16GeneCards, 42Novus Biologicals, 26inGenious Targeting Laboratory See all sources |
Genes related to malignant peripheral nerve sheath tumor:(show all 20)
Products for genes related to malignant peripheral nerve sheath tumor disease:
|
|
|
|
Sources: 1BioGPS See all sources |
  |
|
Sources: 27KEGG, 50Reactome, 34NCBI BioSystems Database, 48QIAGEN See all sources |
Pathways related to malignant peripheral nerve sheath tumor according to GeneCards/GeneDecks:
|
|
Sources: 41Novoseek, 46PharmGKB, 55Tocris Bioscience, 11DrugBank, 22HMDB, 2BitterDB See all sources |
Compounds related to malignant peripheral nerve sheath tumor according to GeneCards/GeneDecks:(show top 50) (show all 105)
|
|
Sources: 15Gene Ontology See all sources |
Cellular components related to malignant peripheral nerve sheath tumor according to GeneCards/GeneDecks:
Biological processes related to malignant peripheral nerve sheath tumor according to GeneCards/GeneDecks:(show all 10)
Molecular functions related to malignant peripheral nerve sheath tumor according to GeneCards/GeneDecks:
|
|
