MPNST
MCID: MLG077
MIFTS: 64

Malignant Peripheral Nerve Sheath Tumor (MPNST) malady

Neuronal diseases, Cancer diseases categories

Summaries for Malignant Peripheral Nerve Sheath Tumor

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A malignant peripheral nerve sheath tumor (mpnst) is a tumor that develops from nerve tissue.  the first symptom of mpnst is a lump or mass that increases in size, sometimes causing pain or a tingling sensation.  mpnst is considered an aggressive tumor because there is up to a 65% chance of the tumor regrowing after surgery (a recurrence), and approximately 40% chance of spreading to distant parts of the body (a metastasis), most commonly to the lung.  treatment of mpnst begins with surgery to remove as much of the tumor as possible.  radiation therapy may be used to decrease the chance of a recurrence.  chemotherapy might be used if the whole tumor cannot be removed during surgery, or to treat a metastasis.  mpnsts are quite rare, occurring in 0.001% of the general population.  approximately 25-50% of mpnsts are associated with a genetic condition known as neurofibromatosis type 1. last updated: 10/18/2011

MalaCards: Malignant Peripheral Nerve Sheath Tumor, also known as MPNST, is related to neurofibromatosis and neurofibroma. An important gene associated with Malignant Peripheral Nerve Sheath Tumor is S100B (S100 calcium binding protein B), and among its related pathways are GPCR Pathway and Glioblastoma Multiforme. The compounds estrogen and glucose have been mentioned in the context of this disorder. Affiliated tissues include lung, bone and kidney, and related mouse phenotypes are limbs/digits/tail and embryogenesis.

Wikipedia:63 A malignant peripheral nerve sheath tumor (MPNST) (also known as \"Malignant schwannoma,\"... more...

Aliases & Classifications for Malignant Peripheral Nerve Sheath Tumor

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48Orphanet, 8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 39NCIt, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
malignant peripheral nerve sheath tumor:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

malignant peripheral nerve sheath tumor 8 42 10 48 60
mpnst 42 44 48
malignant neoplasm of the peripheral nerve sheath 8
malignant peripheral nerve sheath tumors 44
malignant neurilemmoma 48
malignant neurofibroma 48
malignant schwannoma 48
neurogenic sarcoma 48
neurofibrosarcoma 48


External Ids:

Disease Ontology8 DOID:5940
MeSH34 D018317
NCIt39 C3798
SNOMED-CT via Orphanet57 404037002, 19897006, 77418004

Related Diseases for Malignant Peripheral Nerve Sheath Tumor

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Peripheral Nerve Sheath Tumor family:

Benign Peripheral Nerve Sheath Tumor

Diseases related to Malignant Peripheral Nerve Sheath Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 223)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.8KIT, MMP13, NGFR, NF1, NF2, PDGFRA
2neurofibroma31.4NF1, NGFR, MMP13, KIT, NF2, TOP2A
3sarcoma31.2S100B, S100A1, PDGFRA, BMP2, TOP2A, NES
4melanoma31.1S100A6, S100A1, SOX10, PDGFRA, BMP2, TOP2A
5plexiform neurofibroma31.1MMP13, NF1, PDGFRA
6synovial sarcoma31.1CALB2, S100B, NES, NF1, MMP13, KIT
7ganglioneuroma31.0S100B, CHGA, NGFR
8perineurioma30.9S100B
9neurofibrosarcoma30.9NF2, NF1
10neurilemmoma30.7NF2, NF1, SMARCB1
11neuroblastoma30.6NGFR
12angiosarcoma30.6PDGFRA, CALB2
13malignant mesothelioma30.6CALB2, S100A1, NF2, CDKN2A
14pheochromocytoma30.6NGFR, NF1, CHGA, CALB2
15gastrointestinal stromal tumor30.6KIT, PDGFRA
16smooth muscle tumor30.4KIT, S100A1, S100B
17liposarcoma30.4CALB2
18neuropathy30.4MYOG, SOX10
19papillary carcinoma30.4CHGA, S100A1, S100A6, CALB2
20rhabdomyosarcoma30.4CALB2, S100B, S100A1, PDGFRA, NES, MYOG
21seminoma30.4CALB2, PDGFRA, TOP2A, KIT
22adenocarcinoma30.4CALB2, S100A6, BMP2, TOP2A, NES, CHGA
23bladder carcinoma30.4MMP13, CDKN2A, NGFR, TOP2A
24lung cancer30.4CHGA, TOP2A, BMP2, PDGFRA
25medulloblastoma29.9PDGFRA, BMP2, NES, NGFR, SMARCB1, S100B
26thymoma29.8CALB2, NGFR
27ovarian cancer29.8CALB2, PDGFRA, TOP2A, NF2, NGFR, MMP13
28leiomyosarcoma29.8SMARCB1, KIT, CALB2, S100B, S100A1, PDGFRA
29epithelioid malignant peripheral nerve sheath tumor11.0
30peripheral nerve schwannoma10.9
31malignant triton tumor10.8
32cervicitis10.5
33malignant glandular tumor of peripheral nerve sheath10.4
34hepatitis a10.4
35hepatitis10.4
36thyroiditis10.4
37malignant cardiac peripheral nerve sheath neoplasm10.3
38malignant oculomotor nerve tumor10.3
39malignant peritoneal mesothelioma10.3
40malignant spindle cell melanoma10.3
41cellular schwannoma10.3
42plexiform schwannoma10.3
43malignant epithelial mesothelioma10.3
44cervix melanoma10.3
45cerebritis10.3
46bladder carcinoma in situ10.3
47endocervicitis10.3
48childhood malignant schwannoma10.3
49meningocele10.3
50intussusception10.3

Graphical network of the top 20 diseases related to Malignant Peripheral Nerve Sheath Tumor:



Diseases related to malignant peripheral nerve sheath tumor

Clinical Features for Malignant Peripheral Nerve Sheath Tumor

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Drugs & Therapeutics for Malignant Peripheral Nerve Sheath Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Malignant Peripheral Nerve Sheath Tumor

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Anatomical Context for Malignant Peripheral Nerve Sheath Tumor

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32MalaCards
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MalaCards organs/tissues related to Malignant Peripheral Nerve Sheath Tumor:

32
Lung, Bone, Kidney, Breast, Cervix, Brain, Thyroid, Pancreas, Liver, Colon, Spinal cord, Tongue, Skin, Prostate, Testes, Uterus, Eye, Smooth muscle, Heart, Lymph node, Trachea

Animal Models for Malignant Peripheral Nerve Sheath Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Peripheral Nerve Sheath Tumor:

36 (show all 22)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.7SOX10
2MP:000538010.7SOX10, BMP2, NES, NF2, MYOG
3MP:001077110.7S100B, SOX10, PDGFRA, MYOG, CDKN2A, MMP13
4MP:000118610.7NF1
5MP:000537710.6APOD, BMP2, NF2, NF1, NGFR
6MP:000538810.6PDGFRA, PRG2, NF2, NF1, MYOG, NGFR
7MP:000363110.6CALB2, SOX10, APOD, BMP2, NF2, NF1
8MP:000537610.6PDGFRA, APOD, NF2, NF1, MYOG, NGFR
9MP:000539010.6PDGFRA, BMP2, NF2, NF1, MYOG, MMP13
10MP:000287310.5CALB2, S100B, S100A1, SOX10, PDGFRA, BMP2
11MP:000537810.5CHGA, NES, BMP2, PDGFRA, SOX10, NF2
12MP:000538610.5KIT, CALB2, S100B, S100A1, SOX10, PDGFRA
13MP:000536910.5PDGFRA, NF1, NGFR, CDKN2A
14MP:000538110.5SOX10, PDGFRA, BMP2, NGFR, CDKN2A, KIT
15MP:000538510.5S100A1, PDGFRA, BMP2, CHGA, NF1, NGFR
16MP:001076810.5NES, BMP2, APOD, PDGFRA, SOX10, CHGA
17MP:000200610.4PDGFRA, NF2, NF1, CDKN2A, KIT, SMARCB1
18MP:000538410.4SOX10, PDGFRA, BMP2, NES, NF1, NGFR
19MP:000537910.3SOX10, PDGFRA, NF2, NF1, CDKN2A, KIT
20MP:000536710.3KIT, NGFR, NF1, NF2, CHGA, PDGFRA
21MP:000538210.2PDGFRA, BMP2, NF2, NF1, NGFR, KIT
22MP:000537010.0NF2, NF1, NGFR, CDKN2A, KIT, SMARCB1

Publications for Malignant Peripheral Nerve Sheath Tumor

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50PubMed
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Articles related to Malignant Peripheral Nerve Sheath Tumor:

(show top 50)    (show all 433)
idTitleAuthorsYear
1
Benign whole body tumor volume is a risk factor for malignant peripheral nerve sheath tumors in neurofibromatosis type 1. (24166582)
2014
2
Sporadic Multifocal Malignant Peripheral Nerve Sheath Tumor-A Rare Presentation: Multifocal MPNST. (24426502)
2013
3
Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS. (23437333)
2013
4
Malignant peripheral nerve sheath tumor with glandular differentiation in a patient with neurofibromatosis type 1. (24247575)
2013
5
Malignant peripheral nerve sheath tumor invasion requires aberrantly expressed EGF receptors and is variably enhanced by multiple EGF family ligands. (23399900)
2013
6
Comparative effectiveness of 18F-FDG PET/CT versus whole-body MRI for detection of malignant peripheral nerve sheath tumors in neurofibromatosis type 1. (23242059)
2013
7
18F-fluorodeoxyglucose positron emission tomography/computed tomography in a case of malignant peripheral nerve sheath tumor: An unusual presentation. (24250026)
2013
8
Malignant peripheral nerve sheath tumor of kidney-A case report. (23995478)
2013
9
Malignant peripheral nerve sheath tumor of the abducens nerve and a review of the literature. (23022650)
2013
10
Malignant perineurioma (malignant peripheral nerve sheath tumor with perineural differentiation). (22762889)
2012
11
Molecular heterogeneity in malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1. (23244685)
2012
12
A case report of a malignant peripheral nerve sheath tumor of the oral cavity in neurofibromatosis type 1. (23198228)
2012
13
Reconstruction of the chest wall after excision of a giant malignant peripheral nerve sheath tumor. (23238203)
2012
14
Inhibition of Bcl-xL by ABT-737 enhances chemotherapy sensitivity in neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor cells. (22664653)
2012
15
A case of neurofibromatosis type 1 coinciding with bilateral pheochromocytomas, multiple gastrointestinal stromal tumors, and malignant peripheral nerve sheath tumor. (22728486)
2012
16
Coexistent malignant peripheral nerve sheath tumor and lateral spinal meningoceles. (23066463)
2012
17
A case of a sporadic malignant peripheral nerve sheath tumor of the urinary bladder with concomitant in situ urothelial carcinoma treated by transuretheral resection. (21393901)
2011
18
Malignant peripheral nerve sheath tumor of mandible. (21415661)
2011
19
Malignant peripheral nerve sheath tumor of the vestibulocochlear nerve and brainstem: multimodality treatment with survival of 27 months. A case report and review of the literature. (21577168)
2011
20
Intramedullary malignant peripheral nerve sheath tumor. (21556682)
2011
21
Malignant peripheral nerve sheath tumor of the scalp: case report and review of the literature. (21790853)
2011
22
Low grade malignant peripheral nerve sheath tumor with mesenchymal differentiation: a case report. (22246916)
2011
23
Diffuse scalp malignant peripheral nerve sheath tumor with intracranial extension in a patient with neurofibromatosis type 1. (20655235)
2010
24
Clinical effectiveness of boron neutron capture therapy for a recurrent malignant peripheral nerve sheath tumor in the mediastinum. (21102266)
2010
25
Nearly identical near-haploid karyotype in a peritoneal mesothelioma and a retroperitoneal malignant peripheral nerve sheath tumor. (20875874)
2010
26
Malignant peripheral nerve sheath tumor of the tongue. (21045486)
2010
27
Primary disseminated intradural malignant peripheral nerve sheath tumor of the spine in a child: case report and review of the literature. (19521138)
2009
28
Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor. (19417153)
2009
29
Potential role of 18fluorodeoxyglucose-positron emission tomography/computed tomography in differentiating benign neurofibroma from malignant peripheral nerve sheath tumor associated with neurofibromatosis 1. (19927062)
2009
30
Long-term survival after removal of a malignant peripheral nerve sheath tumor originating in the anterior mediastinum. (19533278)
2009
31
Primary uterine cervix melanoma resembling malignant peripheral nerve sheath tumor: a case report. (18753958)
2008
32
A case of intrathoracic giant malignant peripheral nerve sheath tumor in neurofibromatosis type I (von Recklinghausen's disease). (18292741)
2008
33
A case of fibroblastic low-grade malignant peripheral nerve sheath tumor--a true neurofibrosarcoma. (17963184)
2007
34
Epithelioid malignant peripheral nerve sheath tumor in the infraorbital nerve. (16550070)
2006
35
Expression of emmprin and matrix metalloproteinases (MMPs) in peripheral nerve sheath tumors: emmprin and membrane-type (MT)1-MMP expressions are associated with malignant potential. (16619545)
2006
36
Extended remission of a recurrent median nerve malignant peripheral nerve sheath tumor after multimodal treatment. Case report. (16266062)
2005
37
Differential modulation of malignant peripheral nerve sheath tumor growth by omega-3 and omega-6 fatty acids. (15735744)
2005
38
Intraosseous malignant peripheral nerve sheath tumor with local recurrence, lung metastases and death. (14758514)
2004
39
Radiotherapy-induced malignant peripheral nerve sheath tumor of the cauda equina. (15507791)
2004
40
Malignant peripheral nerve sheath tumor of the parotid gland. (12903685)
2003
41
Two novel translocations, t(2;4)(q35;q31) and t(X;12)(q22;q24), as the only karyotypic abnormalities in a malignant peripheral nerve sheath tumor of the skull base. (12935926)
2003
42
Malignant peripheral nerve sheath tumor of the vulva: a multimodal treatment approach. (11972402)
2002
43
Expanding the spectrum of malignant change in schwannomas: epithelioid malignant change, epithelioid malignant peripheral nerve sheath tumor, and epithelioid angiosarcoma: a study of 17 cases. (11145248)
2001
44
H-ras-1 point mutation in malignant peripheral nerve sheath tumors: polymerase chain reaction restriction fragment length polymorphism analysis and direct sequencing from paraffin-embedded tissues. (10812008)
2000
45
Malignant peripheral nerve sheath tumor in a cat. (10608693)
1999
46
Primary intraosseous malignant peripheral nerve sheath tumor: a case report and review of the literature. (9770186)
1998
47
Intraosseous malignant peripheral nerve sheath tumor in a patient with neurofibromatosis. (9677654)
1998
48
Epithelioid variant of malignant peripheral nerve sheath tumor]. (9388863)
1996
49
Cytogenetic analysis of soft tissue sarcomas. Recurrent chromosome abnormalities in malignant peripheral nerve sheath tumors (MPNST). (7828144)
1994
50
Malignant peripheral nerve sheath tumor of the orbit in a 15-month-old child. Nine-year survival after local excision. (1454328)
1992

Genetic Variations for Malignant Peripheral Nerve Sheath Tumor

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Expression for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

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Pathways for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

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51QIAGEN
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Pathways related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4PDGFRA, BMP2, NGFR, MMP13
210.4PDGFRA, NF2, NF1, CDKN2A
3
Hide members
10.4KIT, NGFR, PRG2, BMP2, PDGFRA
4
Hide members
10.3KIT, SOX10, PDGFRA, BMP2, PRG2, NF1

Compounds for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 74)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CALB2, NF1, MYOG
2glucose4410.8NGFR, CDKN2A, MYOG
3forskolin44 49 1112.8MYOG, NGFR
4b 7234410.7S100B, S100A1, CHGA, CALB2
5dopamine44 28 11 2413.7CHGA, NGFR, NF1, NES, BMP2, CALB2
6fatty acid4410.7CDKN2A, NF1, TOP2A, S100A6, MYOG
7mucicarmine4410.7CALB2, S100B, S100A1
8agarose4410.7CDKN2A, S100B, APOD, MMP13, KIT
9silver4410.7CDKN2A, CHGA, S100A1, S100A6, CALB2
10serine4410.7TOP2A, NF1, NF2, S100B, BMP2, MMP13
11paclitaxel44 49 1112.7CDKN2A, CHGA, S100B, TOP2A, CALB2
12hematoxylin4410.7PRG2, S100A1, S100B, CHGA, KIT, CDKN2A
13matrigel4410.7MMP13, CHGA, NES, BMP2, NGFR
14gaba4410.7S100B, NGFR, CHGA, NES, CALB2
15creatinine4410.7BMP2, CHGA, CDKN2A, APOD
16rapamycin4410.7BMP2, NF2, KIT, MYOG, NF1, PDGFRA
17thymidine44 2411.7S100B, TOP2A, PDGFRA, CALB2, BMP2, KIT
18steroid4410.7CALB2, S100A6, BMP2, TOP2A, NF1, MYOG
19acetylcholine44 49 28 11 2414.7MYOG, CHGA, PRG2, NES, CALB2, S100A1
20actinomycin d4410.7MMP13, CDKN2A, PRG2, TOP2A, BMP2, KIT
21oxygen44 2411.7MMP13, CDKN2A, NES, CHGA, MYOG, NGFR
22p0024410.7TOP2A, KIT, CHGA, MMP13
23bromodeoxyuridine4410.6MYOG, CHGA, S100B, NES
24cyclic amp44 2411.6MMP13, CDKN2A, NGFR, NF1, S100B, CHGA
25ribonucleic acid4410.6KIT, BMP2, MMP13, MYOG, CHGA
26choline44 11 2412.6S100B, NGFR, NES, CALB2
27vegf4410.6MMP13, KIT, CHGA, BMP2, CDKN2A, NGFR
28zinc44 2411.6CALB2, S100B, MMP13, S100A6, CHGA, NGFR
29lipid4410.6S100B, BMP2, NES, PRG2, CHGA, NF1
30atp44 2811.6CDKN2A, NF1, CHGA, PRG2, TOP2A, PDGFRA
31dexamethasone44 49 28 1113.6S100B, BMP2, CDKN2A, MMP13
32testosterone44 59 11 2413.6CALB2, APOD, MYOG, S100A6, CHGA, TOP2A
33estracyt4410.6PRG2, CHGA
34oligonucleotide4410.6S100A6, PDGFRA, APOD, BMP2, PRG2, CHGA
35nitric oxide44 11 2412.6MMP13, S100A1, BMP2, CDKN2A, PRG2, CHGA
36nicotine44 49 28 1113.6CHGA, BMP2, CDKN2A, NGFR
37genistein44 28 59 2 11 2415.6CDKN2A, PRG2, TOP2A, BMP2, MMP13
38cysteine4410.6S100A6, MYOG, MMP13, NF1, NF2, CHGA
39progesterone44 59 28 11 2414.6KIT, S100A6, CDKN2A, NGFR, NF1, NF2
40tyrosine4410.5CHGA, KIT, MMP13, TOP2A, NF2, PRG2
41calcium44 49 11 2413.5BMP2, PRG2, PDGFRA, S100A6, S100A1, CALB2
42paraffin4410.5NGFR, MYOG, NF1, NF2, CHGA, NES
43retinoic acid44 2411.5S100B, S100A6, S100A1, CDKN2A, KIT, MMP13
44arginine4410.5S100B, PRG2, CHGA, NF1, CDKN2A, BMP2
45nacl4410.5MMP13, NF1, S100A1, S100A6
46deoxyribonucleic acid4410.5BMP2, NF2, CDKN2A
47plp (139-151)5910.4S100B, PRG2
48threonine4410.4S100B, NF2, KIT, CDKN2A, NGFR, BMP2
49nogo-66 (1-40)5910.3PRG2, S100B
50mog (35-55)5910.1S100B, PRG2

GO Terms for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

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16Gene Ontology
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Cellular components related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.3APOD, BMP2, PRG2, CHGA, NGFR, MMP13
2nucleusGO:0056349.9SMARCB1, S100B, S100A6, S100A1, SOX10, PDGFRA

Biological processes related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:00195310.6CDKN2A, NF1, NF2
2positive regulation of fibroblast proliferationGO:04814610.6S100A6, PDGFRA, NGFR
3positive regulation of apoptotic processGO:04306510.6NGFR, NF1, TOP2A, BMP2, S100B
4negative regulation of cell proliferationGO:00828510.5SMARCB1, CDKN2A, MYOG, NF2, BMP2
5negative regulation of protein kinase activityGO:00646910.5CDKN2A, NF1, NF2
6negative regulation of MAPK cascadeGO:04340910.4NF1, NF2
7positive regulation of transcription from RNA polymerase II promoterGO:04594410.4SOX10, BMP2, TOP2A, MYOG, CDKN2A, SMARCB1
8odontogenesis of dentin-containing toothGO:04247510.4PDGFRA, BMP2, NF2
9positive regulation of phospholipase C activityGO:01086310.3KIT, PDGFRA
10extracellular matrix organizationGO:03019810.1MMP13, NF1, BMP2, PDGFRA

Molecular functions related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein homodimerization activityGO:04280310.3KIT, TOP2A, PDGFRA, S100A1, S100A6, S100B
2S100 protein bindingGO:04454810.3S100A1, S100A6, S100B
3protein bindingGO:0055159.8APOD, PDGFRA, SOX10, S100A1, S100A6, S100B

Products for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

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  • Antibodies
  • Proteins
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Sources for Malignant Peripheral Nerve Sheath Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet