Malignant Peripheral Nerve Sheath Tumor disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

MPNST MCID: MLG077 MIFTS: 64	Malignant Peripheral Nerve Sheath Tumor (MPNST) malady Neuronal diseases, Cancer diseases categories
86 genes, 21 tissues, 223 related diseases, clinical trials.

Summaries for Malignant Peripheral Nerve Sheath Tumor

Sources:
⁴²NIH Rare Diseases, ⁶³Wikipedia, ³²MalaCards
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NIH Rare Diseases:⁴² A malignant peripheral nerve sheath tumor (mpnst) is a tumor that develops from nerve tissue. the first symptom of mpnst is a lump or mass that increases in size, sometimes causing pain or a tingling sensation. mpnst is considered an aggressive tumor because there is up to a 65% chance of the tumor regrowing after surgery (a recurrence), and approximately 40% chance of spreading to distant parts of the body (a metastasis), most commonly to the lung. treatment of mpnst begins with surgery to remove as much of the tumor as possible. radiation therapy may be used to decrease the chance of a recurrence. chemotherapy might be used if the whole tumor cannot be removed during surgery, or to treat a metastasis. mpnsts are quite rare, occurring in 0.001% of the general population. approximately 25-50% of mpnsts are associated with a genetic condition known as neurofibromatosis type 1. last updated: 10/18/2011

MalaCards: Malignant Peripheral Nerve Sheath Tumor, also known as MPNST, is related to neurofibromatosis and neurofibroma. An important gene associated with Malignant Peripheral Nerve Sheath Tumor is S100B (S100 calcium binding protein B), and among its related pathways are GPCR Pathway and Glioblastoma Multiforme. The compounds estrogen and glucose have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and bone, and related mouse phenotypes are limbs/digits/tail and embryogenesis.

Wikipedia:⁶³ A malignant peripheral nerve sheath tumor (MPNST) (also known as \"Malignant schwannoma,\"... more...

Aliases & Classifications for Malignant Peripheral Nerve Sheath Tumor

Sources:
⁴⁸Orphanet, ⁸Disease Ontology, ⁴²NIH Rare Diseases, ¹⁰DISEASES, ⁶⁰UMLS, ⁴⁴Novoseek, ⁵⁶SNOMED-CT, ³⁴MeSH, ³⁹NCIt, ⁵⁷SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases

Characteristics (Orphanet epidemiological data):

⁴⁸

malignant peripheral nerve sheath tumor:
Inheritance: Sporadic; Age of onset: Variable

Aliases & Descriptions:

malignant peripheral nerve sheath tumor ⁸ ⁴² ¹⁰ ⁴⁸ ⁶⁰

mpnst ⁴² ⁴⁴ ⁴⁸

malignant neoplasm of the peripheral nerve sheath ⁸

malignant peripheral nerve sheath tumors ⁴⁴

malignant neurilemmoma ⁴⁸

malignant neurofibroma ⁴⁸

malignant schwannoma ⁴⁸

neurogenic sarcoma ⁴⁸

neurofibrosarcoma ⁴⁸

External Ids:

Disease Ontology⁸ DOID:5940

MeSH³⁴ D018317

SNOMED-CT⁵⁶ 19897006, 404037002, 134324009

NCIt³⁹ C3798

SNOMED-CT via Orphanet⁵⁷ 404037002, 19897006, 77418004

UMLS⁶⁰ C0751690

Related Diseases for Malignant Peripheral Nerve Sheath Tumor

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Malignant Peripheral Nerve Sheath Tumor family:

Benign Peripheral Nerve Sheath Tumor

Diseases related to Malignant Peripheral Nerve Sheath Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 223)

id	Related Disease	Score	Top Affiliating Genes
1	neurofibromatosis	31.8	KIT, MMP13, NGFR, NF1, NF2, PDGFRA
2	neurofibroma	31.4	NF1, NGFR, MMP13, KIT, NF2, TOP2A
3	sarcoma	31.2	S100B, S100A1, PDGFRA, BMP2, TOP2A, NES
4	melanoma	31.1	S100A6, S100A1, SOX10, PDGFRA, BMP2, TOP2A
5	plexiform neurofibroma	31.1	MMP13, NF1, PDGFRA
6	synovial sarcoma	31.1	CALB2, S100B, NES, NF1, MMP13, KIT
7	ganglioneuroma	31.0	S100B, CHGA, NGFR
8	perineurioma	30.9	S100B
9	neurofibrosarcoma	30.9	NF2, NF1
10	neurilemmoma	30.7	NF2, NF1, SMARCB1
11	neuroblastoma	30.6	NGFR
12	angiosarcoma	30.6	PDGFRA, CALB2
13	malignant mesothelioma	30.6	CALB2, S100A1, NF2, CDKN2A
14	pheochromocytoma	30.6	NGFR, NF1, CHGA, CALB2
15	gastrointestinal stromal tumor	30.6	KIT, PDGFRA
16	smooth muscle tumor	30.4	KIT, S100A1, S100B
17	liposarcoma	30.4	CALB2
18	neuropathy	30.4	MYOG, SOX10
19	papillary carcinoma	30.4	CHGA, S100A1, S100A6, CALB2
20	rhabdomyosarcoma	30.4	CALB2, S100B, S100A1, PDGFRA, NES, MYOG
21	seminoma	30.4	CALB2, PDGFRA, TOP2A, KIT
22	adenocarcinoma	30.4	CALB2, S100A6, BMP2, TOP2A, NES, CHGA
23	bladder carcinoma	30.4	MMP13, CDKN2A, NGFR, TOP2A
24	lung cancer	30.4	CHGA, TOP2A, BMP2, PDGFRA
25	medulloblastoma	29.9	PDGFRA, BMP2, NES, NGFR, SMARCB1, S100B
26	thymoma	29.8	CALB2, NGFR
27	ovarian cancer	29.8	CALB2, PDGFRA, TOP2A, NF2, NGFR, MMP13
28	leiomyosarcoma	29.8	SMARCB1, KIT, CALB2, S100B, S100A1, PDGFRA
29	epithelioid malignant peripheral nerve sheath tumor	11.0
30	peripheral nerve schwannoma	10.9
31	malignant triton tumor	10.8
32	cervicitis	10.5
33	malignant glandular tumor of peripheral nerve sheath	10.4
34	hepatitis a	10.4
35	hepatitis	10.4
36	thyroiditis	10.4
37	malignant cardiac peripheral nerve sheath neoplasm	10.3
38	malignant oculomotor nerve tumor	10.3
39	malignant peritoneal mesothelioma	10.3
40	malignant spindle cell melanoma	10.3
41	cellular schwannoma	10.3
42	plexiform schwannoma	10.3
43	malignant epithelial mesothelioma	10.3
44	cervix melanoma	10.3
45	cerebritis	10.3
46	bladder carcinoma in situ	10.3
47	endocervicitis	10.3
48	childhood malignant schwannoma	10.3
49	meningocele	10.3
50	intussusception	10.3

Graphical network of the top 20 diseases related to Malignant Peripheral Nerve Sheath Tumor:

Clinical Features for Malignant Peripheral Nerve Sheath Tumor

Drugs & Therapeutics for Malignant Peripheral Nerve Sheath Tumor

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Peripheral Nerve Sheath Tumor

Drug clinical trials:

Search ClinicalTrials for Malignant Peripheral Nerve Sheath Tumor

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Search CenterWatch for Malignant Peripheral Nerve Sheath Tumor

Genetic Tests for Malignant Peripheral Nerve Sheath Tumor

Anatomical Context for Malignant Peripheral Nerve Sheath Tumor

Sources:
³²MalaCards
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MalaCards organs/tissues related to Malignant Peripheral Nerve Sheath Tumor:

³²

Lung, Kidney, Bone, Breast, Cervix, Brain, Thyroid, Colon, Pancreas, Liver, Skin, Spinal cord, Tongue, Smooth muscle, Prostate, Heart, Uterus, Testes, Eye, Lymph node, Trachea

Animal Models for Malignant Peripheral Nerve Sheath Tumor or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Malignant Peripheral Nerve Sheath Tumor:

³⁶ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail phenotype	MP:0005371	10.7	SOX10
2	embryogenesis phenotype	MP:0005380	10.7	SOX10, BMP2, NES, NF2, MYOG
3	integument phenotype	MP:0010771	10.7	S100B, SOX10, PDGFRA, MYOG, CDKN2A, MMP13
4	pigmentation phenotype	MP:0001186	10.7	NF1
5	hearing/vestibular/ear phenotype	MP:0005377	10.6	APOD, BMP2, NF2, NF1, NGFR
6	respiratory system phenotype	MP:0005388	10.6	PDGFRA, PRG2, NF2, NF1, MYOG, NGFR
7	nervous system phenotype	MP:0003631	10.6	CALB2, SOX10, APOD, BMP2, NF2, NF1
8	homeostasis/metabolism phenotype	MP:0005376	10.6	PDGFRA, APOD, NF2, NF1, MYOG, NGFR
9	skeleton phenotype	MP:0005390	10.6	PDGFRA, BMP2, NF2, NF1, MYOG, MMP13
10	normal phenotype	MP:0002873	10.5	CALB2, S100B, S100A1, SOX10, PDGFRA, BMP2
11	growth/size phenotype	MP:0005378	10.5	CHGA, NES, BMP2, PDGFRA, SOX10, NF2
12	behavior/neurological phenotype	MP:0005386	10.5	KIT, CALB2, S100B, S100A1, SOX10, PDGFRA
13	muscle phenotype	MP:0005369	10.5	PDGFRA, NF1, NGFR, CDKN2A
14	digestive/alimentary phenotype	MP:0005381	10.5	SOX10, PDGFRA, BMP2, NGFR, CDKN2A, KIT
15	cardiovascular system phenotype	MP:0005385	10.5	S100A1, PDGFRA, BMP2, CHGA, NF1, NGFR
16	mortality/aging	MP:0010768	10.5	NES, BMP2, APOD, PDGFRA, SOX10, CHGA
17	tumorigenesis	MP:0002006	10.4	PDGFRA, NF2, NF1, CDKN2A, KIT, SMARCB1
18	cellular phenotype	MP:0005384	10.4	SOX10, PDGFRA, BMP2, NES, NF1, NGFR
19	endocrine/exocrine gland phenotype	MP:0005379	10.3	SOX10, PDGFRA, NF2, NF1, CDKN2A, KIT
20	renal/urinary system phenotype	MP:0005367	10.3	KIT, NGFR, NF1, NF2, CHGA, PDGFRA
21	craniofacial phenotype	MP:0005382	10.2	PDGFRA, BMP2, NF2, NF1, NGFR, KIT
22	liver/biliary system phenotype	MP:0005370	10.0	NF2, NF1, NGFR, CDKN2A, KIT, SMARCB1

Publications for Malignant Peripheral Nerve Sheath Tumor

Sources:
⁵⁰PubMed
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Articles related to Malignant Peripheral Nerve Sheath Tumor:

(show top 50) (show all 433)

id	Title	Authors	Year
1	Malignant peripheral nerve sheath tumor as a cause of chronic cardiac insufficiency in cattle. (23369465)	Pavarini S.P.... Farias da Cruz C.E.	2013
2	Imaging diagnosis-malignant peripheral nerve sheath tumor presenting as an intra-axial brain mass in a young dog. (23363000)	Shihab N.... Volk H.A.	2013
3	Primary intrapulmonary malignant peripheral nerve sheath tumor mimicking lung cancer. (23991328)	La Mantia E.... Rocco G.	2013
4	Expression profiling of 519 kinase genes in matched malignant peripheral nerve sheath tumor/plexiform neurofibroma samples is discriminatory and identifies mitotic regulators BUB1B, PBK and NEK2 as overexpressed with transformation. (23370767)	Stricker T.P.... Pytel P.	2013
5	Malignant peripheral nerve sheath tumor of non-neurofibromatosis type I metastasized to the cerebrospinal axis. (23634272)	Park M.K.... Kim K.T.	2013
6	Clinical and molecular prognostic predictors of malignant peripheral nerve sheath tumor. (23749326)	Fan Q.... Wang G.	2013
7	Low-grade malignant triton tumor in the lumbar spine: a rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. (21732991)	Prieto R.... GonzA!lez-Llanos F.	2012
8	Malignant peripheral nerve sheath tumor of the superior cervical sympathetic ganglia. (23076858)	Thariat J.... Venissac N.	2012
9	Ras-driven transcriptome analysis identifies aurora kinase A as a potential malignant peripheral nerve sheath tumor therapeutic target. (22811580)	Patel A.V.... Ratner N.	2012
10	Telomere maintenance mechanisms in malignant peripheral nerve sheath tumors: expression and prognostic relevance. (22516689)	Venturini L.... Zaffaroni N.	2012
11	Favorable outcome after radical resection and subsequent local irradiation of malignant peripheral nerve sheath tumor in the cervical spine. (23006884)	Sasamori T.... Houkin K.	2012
12	Report of a case of malignant peripheral nerve sheath tumor of the neck with an early local recurrence. (22033963)	Edizer D.T.... IA9A+ldak H.	2011
13	Orthotopic xenografting of human luciferase-tagged malignant peripheral nerve sheath tumor cells for in vivo testing of candidate therapeutic agents. (21460792)	Turk A.N.... Carroll S.L.	2011
14	Discovery of a small molecule targeting IRA2 deletion in budding yeast and neurofibromin loss in malignant peripheral nerve sheath tumor cells. (21697395)	Wood M.... Sanchez Y.	2011
15	Malignant peripheral nerve sheath tumor in a patient with juvenile-onset dermatomyositis. (21441814)	Tamaki H.... Okada M.	2011
16	Malignant transformation in a hybrid schwannoma/perineurioma: addition to the spectrum of a malignant peripheral nerve sheath tumor. (22234123)	Rekhi B.... Jambhekar N.A.	2011
17	Cervicothoracic malignant peripheral nerve sheath tumor. (21674466)	Lin H.W.... Reilly B.K.	2011
18	Malignant peripheral nerve sheath tumor of the vagus nerve in a teenager with the neurofibromatosis 1 gene mutation: a case report. (21843710)	Sesenna E.... Ferri A.	2011
19	Endocervical fibroblastic malignant peripheral nerve sheath tumor (neurofibrosarcoma): report of a novel entity possibly related to endocervical CD34 fibrocytes. (21317712)	Mills A.M.... Longacre T.A.	2011
20	Lymph node metastasis of malignant peripheral nerve sheath tumor in the absence of widespread disease five years after diagnosis: a rare finding. (21151396)	Godfrey G.J.... Farghaly H.	2010
21	Liposarcomatous differentiation in malignant peripheral nerve sheath tumor: a case report. (19433348)	Tirabosco R.... Flanagan A.M.	2010
22	Clinical course of a malignant peripheral nerve sheath tumor in a Siberian tiger (Panthera tigris altaica). (21088186)	Steinmetz H.W.... Hatt J.M.	2010
23	Abrogating drug resistance in malignant peripheral nerve sheath tumors by disrupting hyaluronan-CD44 interactions with small hyaluronan oligosaccharides. (19470767)	Slomiany M.G.... Toole B.P.	2009
24	Fine needle aspiration cytology of a primary malignant peripheral nerve sheath tumor arising in the parotid gland: a case report. (19697728)	Nepka C.... Koukoulis G.	2009
25	Malignant Peripheral Nerve Sheath Tumor: molecular pathogenesis and current management considerations. (18286466)	Grobmyer S.R.... Hochwald S.N.	2008
26	Isolated malignant peripheral nerve sheath tumor of kidney capsule. (19259060)	Jankulovski N.... Popov Z.	2008
27	Ras signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpes. (18988803)	Farassati F.... Kurtz A.	2008
28	Imatinib mesylate inhibits cell invasion of malignant peripheral nerve sheath tumor induced by platelet-derived growth factor-BB. (17558420)	Aoki M.... Iwasaki H.	2007
29	Multicentric malignant peripheral nerve sheath tumor. (17825749)	Ozturk E.... Kizilkaya E.	2007
30	Primary pulmonary malignant peripheral nerve sheath tumor: a case report. (17910355)	Tashiro T.... Sano N.	2007
31	A case of intra-dural malignant peripheral nerve sheath tumor in thoracic spine associated with neurofibromatosis type 1. (16598431)	Albayrak B.S.... Kose T.	2006
32	Malignant peripheral nerve sheath tumor originating in neurofibroma of the mesentery. Case report. (16334983)	GA^recki T.... Wojnowski S.	2005
33	Malignant peripheral nerve sheath tumor of the orbit: case report and literature review. (16145592)	Aydin M.D.... Ozdikici M.	2004
34	Giant malignant peripheral nerve sheath tumor of the neck in a patient with neurofibromatosis-1. (15488983)	Topal O.... OA9retmenoA9lu O.	2004
35	Primary malignant peripheral nerve sheath tumor of the cauda equina in a child case report. (15001982)	Yone K.... Komiya S.	2004
36	Malignant peripheral nerve sheath tumor of the mediastinum: a temporary aortic transection approach. (15457164)	Asai K.... Kazui T.	2004
37	Transcriptional mRNA of BMP-2, 3, 4 and 5 in trigeminal nerve, benign and malignant peripheral nerve sheath tumors. (11642720)	Jin Y.... Tipoe G.L.	2001
38	Multiple recurrences in malignant peripheral nerve sheath tumor of the orbit: a case report and a review of the literature. (11476181)	Dutton J.J.... Klintworth G.K.	2001
39	Image interpretation session: 1999. Intraosseous malignant peripheral nerve sheath tumor (malignant schwannoma) in a patient with neurofibromatosis. (10682790)	Dunnick N.R.	2000
40	Images in cardiovascular medicine. A malignant peripheral nerve sheath tumor presenting as an intrapericardial mass. (10929747)	Viel E.... Canterin F.A.	2000
41	Histopathologic features of malignant peripheral nerve sheath tumor are not restricted to metastatic malignant melanoma and can be found in primary malignant melanoma also. (11023110)	Diaz-Cascajo C.... Hoos A.	2000
42	Metastatic malignant melanoma resembling malignant peripheral nerve sheath tumor: report of 16 cases. (10584703)	King R.... Rosai J.	1999
43	Solitary malignant peripheral nerve sheath tumor of the pancreas. (10228853)	Titus A.S.... Vickers S.M.	1999
44	Malignant peripheral nerve sheath tumor of the prostate: a rare manifestion of neurofibromatosis type 1. (10379768)	Rames R.A.... Smith M.T.	1999
45	Malignant peripheral nerve sheath tumor with perineurial cell differentiation (malignant perineurioma). (10227727)	ZA!mecnA-k M.... Michal M.	1999
46	Small round-cell type of malignant peripheral nerve sheath tumor. (9720503)	Abe S.... Tateishi A.	1998
47	Malignant peripheral nerve sheath tumor: analysis of treatment outcome. (9788415)	Wong W.W.... Gunderson L.L.	1998
48	A resected case of malignant peripheral nerve sheath tumor (MPNST) necessary to distinguish from Askin tumor]. (9884581)	Odaka M.... Yamazaki Y.	1998
49	Recurrent orbital malignant peripheral nerve sheath tumor 18 years after initial resection. (9430299)	Morton A.D.... Frueh B.	1997
50	Malignant peripheral nerve sheath tumor. An immunohistochemical study of 62 cases. (2435144)	Wick M.R.... Manivel J.C.	1987

Genes related to Malignant Peripheral Nerve Sheath Tumor

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Malignant Peripheral Nerve Sheath Tumor:

(show top 50) (show all 86)

id	Symbol	Description	Score	Implication
1	S100B	S100 calcium binding protein B	20.13	GeneCards inferred : Publications, Disorders (show sections)
2	NGFR	nerve growth factor receptor	19.90	GeneCards inferred : Publications, Disorders (show sections)
3	NF2	neurofibromin 2 (merlin)	19.67	GeneCards inferred : Publications, Disorders (show sections)
4	MMP13	matrix metallopeptidase 13 (collagenase 3)	19.43	GeneCards inferred : Publications, Disorders (show sections)
5	SOX10	SRY (sex determining region Y)-box 10	19.20	GeneCards inferred : Publications, Disorders (show sections)
6	NES	nestin	18.97	GeneCards inferred : Publications, Disorders (show sections)
7	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	18.74	GeneCards inferred : Publications, Disorders (show sections)
8	CDKN2A	cyclin-dependent kinase inhibitor 2A	18.50	GeneCards inferred : Publications, Disorders (show sections)
9	NF1	neurofibromin 1	18.27	GeneCards inferred : Publications, Disorders (show sections)
10	CHGA	chromogranin A (parathyroid secretory protein 1)	18.04	GeneCards inferred : Publications, Disorders (show sections)
11	BMP2	bone morphogenetic protein 2	17.81	GeneCards inferred : Publications, Disorders (show sections)
12	APOD	apolipoprotein D	17.57	GeneCards inferred : Disorders (show sections)
13	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	17.34	GeneCards inferred : Publications, Disorders (show sections)
14	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	17.11	GeneCards inferred : Publications, Disorders (show sections)
15	S100A1	S100 calcium binding protein A1	16.88	GeneCards inferred : Publications, Disorders (show sections)
16	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	16.64	GeneCards inferred : Publications, Disorders (show sections)
17	TOP2A	topoisomerase (DNA) II alpha 170kDa	16.41	GeneCards inferred : Publications, Disorders (show sections)
18	MYOG	myogenin (myogenic factor 4)	16.18	GeneCards inferred : Disorders (show sections)
19	S100A6	S100 calcium binding protein A6	15.95	GeneCards inferred : Publications, Disorders (show sections)
20	CALB2	calbindin 2	15.71	GeneCards inferred : Disorders (show sections)
21	TERT	telomerase reverse transcriptase	15.48	GeneCards inferred : Publications, Disorders (show sections)
22	MDM2	MDM2 oncogene, E3 ubiquitin protein ligase	15.25	GeneCards inferred : Publications, Disorders (show sections)
23	CD34	CD34 molecule	15.02	GeneCards inferred : Disorders (show sections)
24	VIM	vimentin	14.78	GeneCards inferred : Publications, Disorders (show sections)
25	EGFR	epidermal growth factor receptor	14.55	GeneCards inferred : Publications, Disorders (show sections)
26	MITF	microphthalmia-associated transcription factor	14.32	GeneCards inferred : Disorders (show sections)
27	CD44	CD44 molecule (Indian blood group)	14.08	GeneCards inferred : Publications, Disorders (show sections)
28	CSF3	colony stimulating factor 3 (granulocyte)	13.85	GeneCards inferred : Publications, Disorders (show sections)
29	NCAM1	neural cell adhesion molecule 1	13.62	GeneCards inferred : Disorders (show sections)
30	NRG1	neuregulin 1	13.39	GeneCards inferred : Publications, Disorders (show sections)
31	SIX1	SIX homeobox 1	13.15	GeneCards inferred : Publications, Disorders (show sections)
32	S100A2	S100 calcium binding protein A2	12.92	GeneCards inferred : Publications, Disorders (show sections)
33	HGFAC	HGF activator	12.68	GeneCards inferred : Publications, Disorders (show sections)
34	MIR21	microRNA 21	12.45	GeneCards inferred : Publications, Disorders (show sections)
35	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	12.22	GeneCards inferred : Publications, Disorders (show sections)
36	ACTC1	actin, alpha, cardiac muscle 1	11.99	GeneCards inferred : Publications, Disorders (show sections)
37	B3GAT1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	11.75	GeneCards inferred : Publications, Disorders (show sections)
38	BMP3	bone morphogenetic protein 3	11.52	GeneCards inferred : Publications, Disorders (show sections)
39	ETV4	ets variant 4	11.29	GeneCards inferred : Publications, Disorders (show sections)
40	TERC	telomerase RNA component	11.06	GeneCards inferred : Publications, Disorders (show sections)
41	BMP4	bone morphogenetic protein 4	10.82	GeneCards inferred : Publications, Disorders (show sections)
42	HMGA1	high mobility group AT-hook 1	10.59	GeneCards inferred : Publications, Disorders (show sections)
43	HMGA2	high mobility group AT-hook 2	10.36	GeneCards inferred : Publications, Disorders (show sections)
44	CDK4	cyclin-dependent kinase 4	10.13	GeneCards inferred : Publications, Disorders (show sections)
45	NRAS	neuroblastoma RAS viral (v-ras) oncogene homolog	9.89	GeneCards inferred : Publications, Disorders (show sections)
46	LOXL2	lysyl oxidase-like 2	9.66	GeneCards inferred : Publications, Disorders (show sections)
47	IRS2	insulin receptor substrate 2	9.43	GeneCards inferred : Publications, Disorders (show sections)
48	CHFR	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase	9.20	GeneCards inferred : Publications, Disorders (show sections)
49	MET	met proto-oncogene	8.96	GeneCards inferred : Publications, Disorders (show sections)
50	MUC1	mucin 1, cell surface associated	8.73	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Malignant Peripheral Nerve Sheath Tumor disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	46	46	47
2	LSBio	-	-	50

Genetic Variations for Malignant Peripheral Nerve Sheath Tumor

Expression for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

Search GEO for disease gene expression data for Malignant Peripheral Nerve Sheath Tumor.

Pathways for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

Sources:
⁵¹QIAGEN
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Pathways related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	GPCR Pathway⁵¹ Hide members Pancreatic Adenocarcinoma⁵¹ Breast Cancer Regulation by Stathmin1⁵¹ Ras Pathway⁵¹ Paxillin Interactions⁵¹ NFAT in Immune Response⁵¹ Estrogen Pathway⁵¹ P2Y Receptor Signaling⁵¹	10.4	PDGFRA, BMP2, NGFR, MMP13
2	Glioblastoma Multiforme⁵¹	10.4	PDGFRA, NF2, NF1, CDKN2A
3	PTEN Pathway⁵¹ Hide members Phospholipase-C Pathway⁵¹	10.4	KIT, NGFR, PRG2, BMP2, PDGFRA
4	Rho Family GTPases⁵¹ Hide members ILK Signaling⁵¹ Molecular Mechanisms of Cancer⁵¹ ERK Signaling⁵¹ MAPK Signaling⁵¹	10.3	KIT, SOX10, PDGFRA, BMP2, PRG2, NF1

Compounds for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

Sources:
⁴⁴Novoseek, ⁴⁹PharmGKB, ¹¹DrugBank, ²⁸IUPHAR, ²⁴HMDB, ⁵⁹Tocris Bioscience, ²BitterDB
See all sources

Compounds related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

(show top 50) (show all 74)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.8	CALB2, NF1, MYOG
2	glucose⁴⁴	10.8	CDKN2A, NGFR, MYOG
3	forskolin⁴⁴ ⁴⁹ ¹¹	12.8	NGFR, MYOG
4	b 723⁴⁴	10.7	CALB2, S100B, S100A1, CHGA
5	dopamine⁴⁴ ²⁸ ¹¹ ²⁴	13.7	CALB2, BMP2, NES, CHGA, NF1, NGFR
6	fatty acid⁴⁴	10.7	S100A6, TOP2A, NF1, MYOG, CDKN2A
7	mucicarmine⁴⁴	10.7	CALB2, S100B, S100A1
8	agarose⁴⁴	10.7	S100B, APOD, CDKN2A, MMP13, KIT
9	silver⁴⁴	10.7	CALB2, S100A6, S100A1, CHGA, CDKN2A
10	serine⁴⁴	10.7	S100B, BMP2, TOP2A, NF2, NF1, MYOG
11	paclitaxel⁴⁴ ⁴⁹ ¹¹	12.7	CALB2, S100B, TOP2A, CHGA, CDKN2A
12	hematoxylin⁴⁴	10.7	CALB2, S100B, S100A1, PRG2, CHGA, NGFR
13	matrigel⁴⁴	10.7	MMP13, NGFR, CHGA, NES, BMP2
14	gaba⁴⁴	10.7	CALB2, S100B, NES, CHGA, NGFR
15	creatinine⁴⁴	10.7	APOD, BMP2, CHGA, CDKN2A
16	rapamycin⁴⁴	10.7	PDGFRA, BMP2, NF2, NF1, MYOG, KIT
17	thymidine⁴⁴ ²⁴	11.7	CALB2, S100B, PDGFRA, BMP2, TOP2A, NGFR
18	steroid⁴⁴	10.7	CALB2, S100A6, BMP2, TOP2A, NF1, MYOG
19	acetylcholine⁴⁴ ⁴⁹ ²⁸ ¹¹ ²⁴	14.7	CALB2, S100B, S100A1, NES, PRG2, CHGA
20	actinomycin d⁴⁴	10.7	BMP2, TOP2A, PRG2, CDKN2A, MMP13, KIT
21	oxygen⁴⁴ ²⁴	11.7	S100B, BMP2, NES, PRG2, CHGA, MYOG
22	p002⁴⁴	10.7	TOP2A, CHGA, MMP13, KIT
23	bromodeoxyuridine⁴⁴	10.6	MYOG, CHGA, NES, S100B
24	cyclic amp⁴⁴ ²⁴	11.6	S100B, CHGA, NF1, NGFR, CDKN2A, MMP13
25	ribonucleic acid⁴⁴	10.6	BMP2, CHGA, MYOG, MMP13, KIT
26	choline⁴⁴ ¹¹ ²⁴	12.6	CALB2, S100B, NES, NGFR
27	vegf⁴⁴	10.6	S100B, PDGFRA, BMP2, TOP2A, NES, CHGA
28	zinc⁴⁴ ²⁴	11.6	CALB2, S100B, S100A6, S100A1, PRG2, CHGA
29	lipid⁴⁴	10.6	S100B, APOD, BMP2, NES, PRG2, CHGA
30	atp⁴⁴ ²⁸	11.6	S100B, S100A6, PDGFRA, TOP2A, PRG2, CHGA
31	dexamethasone⁴⁴ ⁴⁹ ²⁸ ¹¹	13.6	S100B, BMP2, CDKN2A, MMP13
32	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	13.6	APOD, S100A6, S100B, CALB2, BMP2, TOP2A
33	estracyt⁴⁴	10.6	CHGA, PRG2
34	oligonucleotide⁴⁴	10.6	PRG2, BMP2, APOD, PDGFRA, S100A6, CHGA
35	nitric oxide⁴⁴ ¹¹ ²⁴	12.6	CALB2, S100B, S100A1, BMP2, NES, PRG2
36	nicotine⁴⁴ ⁴⁹ ²⁸ ¹¹	13.6	BMP2, CHGA, NGFR, CDKN2A
37	genistein⁴⁴ ²⁸ ⁵⁹ ² ¹¹ ²⁴	15.6	MMP13, CDKN2A, PRG2, TOP2A, BMP2
38	cysteine⁴⁴	10.6	PRG2, BMP2, S100A1, S100A6, S100B, CHGA
39	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	14.6	CALB2, KIT, CDKN2A, NGFR, S100B, S100A6
40	tyrosine⁴⁴	10.5	TOP2A, BMP2, PDGFRA, S100A1, S100B, CALB2
41	calcium⁴⁴ ⁴⁹ ¹¹ ²⁴	13.5	BMP2, PDGFRA, S100A1, S100A6, S100B, CALB2
42	paraffin⁴⁴	10.5	CALB2, S100B, S100A6, S100A1, PDGFRA, APOD
43	retinoic acid⁴⁴ ²⁴	11.5	CHGA, NF1, MYOG, NGFR, CDKN2A, MMP13
44	arginine⁴⁴	10.5	S100B, BMP2, PRG2, CHGA, NF1, CDKN2A
45	nacl⁴⁴	10.5	S100A6, S100A1, NF1, MMP13
46	deoxyribonucleic acid⁴⁴	10.5	CDKN2A, NF2, BMP2
47	ono 2506⁵⁹	10.4	PRG2, S100B
48	threonine⁴⁴	10.4	S100B, BMP2, NF2, NGFR, CDKN2A, KIT
49	mog (35-55)⁵⁹	10.3	PRG2, S100B
50	nogo-66 (1-40)⁵⁹	10.1	PRG2, S100B

GO Terms for genes affiliated with Malignant Peripheral Nerve Sheath Tumor

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	10.3	APOD, BMP2, PRG2, CHGA, NGFR, MMP13
2	nucleus	GO:005634	9.9	SMARCB1, S100B, S100A6, S100A1, SOX10, PDGFRA

Biological processes related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell-matrix adhesion	GO:001953	10.6	CDKN2A, NF1, NF2
2	positive regulation of fibroblast proliferation	GO:048146	10.6	S100A6, PDGFRA, NGFR
3	positive regulation of apoptotic process	GO:043065	10.6	NGFR, NF1, TOP2A, BMP2, S100B
4	negative regulation of cell proliferation	GO:008285	10.5	SMARCB1, CDKN2A, MYOG, NF2, BMP2
5	negative regulation of protein kinase activity	GO:006469	10.5	CDKN2A, NF1, NF2
6	negative regulation of MAPK cascade	GO:043409	10.4	NF1, NF2
7	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.4	SOX10, BMP2, TOP2A, MYOG, CDKN2A, SMARCB1
8	odontogenesis of dentin-containing tooth	GO:042475	10.4	PDGFRA, BMP2, NF2
9	positive regulation of phospholipase C activity	GO:010863	10.3	KIT, PDGFRA
10	extracellular matrix organization	GO:030198	10.1	MMP13, NF1, BMP2, PDGFRA

Molecular functions related to Malignant Peripheral Nerve Sheath Tumor according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	10.3	KIT, TOP2A, PDGFRA, S100A1, S100A6, S100B
2	S100 protein binding	GO:044548	10.3	S100A1, S100A6, S100B
3	protein binding	GO:005515	9.8	APOD, PDGFRA, SOX10, S100A1, S100A6, S100B