MCID: MLG002
MIFTS: 57

Malignant Peritoneal Mesothelioma malady

Cancer diseases, Rare diseases categories
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Summaries for Malignant Peritoneal Mesothelioma

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MalaCards based summary: Malignant Peritoneal Mesothelioma, also known as diffuse malignant peritoneal mesothelioma, is related to li-fraumeni syndrome and melanoma, and has symptoms including anomalies of the abdominal wall, ascitis and acute abdominal pain/colic. An important gene associated with Malignant Peritoneal Mesothelioma is HAS1 (hyaluronan synthase 1), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and MNAR-PELP1 and Estrogen Receptor Interaction. The compounds butylparaben and 2,4,6-trichloro-4-biphenylol have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and lymph node, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Malignant Peritoneal Mesothelioma

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Sources:
62UMLS, 10DISEASES, 48Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Malignant Peritoneal Mesothelioma, Aliases & Descriptions:

Name: Malignant Peritoneal Mesothelioma 10 48
Diffuse Malignant Peritoneal Mesothelioma 48
 
Primary Malignant Peritoneal Mesothelioma 48
Malignant Mesothelioma of Peritoneum 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 48 
Rare tumors


Characteristics (Orphanet epidemiological data):

48
malignant peritoneal mesothelioma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


External Ids:

ICD10 via Orphanet26 C45.1
UMLS via Orphanet63 C0346109

Related Diseases for Malignant Peritoneal Mesothelioma

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Diseases in the Peritoneal Mesothelioma family:

Benign Peritoneal Mesothelioma malignant peritoneal mesothelioma

Diseases related to Malignant Peritoneal Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1li-fraumeni syndrome30.3ESR2, ESR1
2melanoma29.7VIM, ANGPT1, CALB2, BIRC5, HMGB1
3ovarian cancer28.9CLDN3, ESR2, ESR1, MUC16, MUC1, ANGPT1
4adenocarcinoma28.0CLDN3, ESR2, ESR1, VIM, MUC16, MUC1
5peritoneal mesothelioma11.4
6peritonitis11.4
7hidradenoma10.6MUC1
8syringoma10.6MUC1
9ovarian serous cystadenocarcinoma10.5MUC16
10pericardial effusion10.5MUC16
11ovarian cystadenoma10.5MUC16
12paraganglioma10.5VIM
13kidney cancer10.4EGFR
14adenomatoid tumor10.4CALB2, VIM
15cystadenocarcinoma10.4MUC1, MUC16
16clear cell ependymoma10.4MUC1, VIM
17sertoli-leydig cell tumor10.4MUC1, CALB2
18mesenchymal chondrosarcoma10.4VIM, MUC1
19progesterone resistance10.4ESR1
20malignant pleural mesothelioma10.4KAZALD1, CALB2
21spindle cell carcinoma10.4MUC1, VIM
22thymus cancer10.4MUC1, CALB2
23spindle cell sarcoma10.4VIM, MUC1
24giant cell glioblastoma10.4EGFR
25granular cell tumor10.4VIM, CALB2
26adenofibroma10.4MUC16, CALB2
27mucinous cystadenocarcinoma10.4MUC16, MUC1
28adenosarcoma10.4ESR1
29papillary adenocarcinoma10.4MUC16, MUC1
30intestinal obstruction10.4
31seminoma10.4
32dermatofibrosarcoma protuberans10.4VIM, MUC1
33secretory meningioma10.4VIM, MUC1
34perineurioma10.4MUC1, VIM
35rhabdoid tumor10.4MUC1, VIM
36hemangiopericytoma10.4MUC1, VIM
37ovarian disease10.3ESR1
38malignant mixed mullerian tumor10.3MUC1, VIM
39chordoma10.3MUC1, VIM
40ovarian cyst10.3ESR2, MUC16
41sertoli cell tumor10.3CALB2, MUC1, VIM
42sex cord-gonadal stromal tumor10.3VIM, MUC1, CALB2
43synovial sarcoma10.3CALB2, MUC1, VIM
44neurilemmoma10.3VIM, MUC1, CALB2
45malignant peripheral nerve sheath tumor10.3VIM, MUC1
46fibroma10.3CALB2, MUC16, VIM
47mammary paget's disease10.3MUC1, ESR1
48giant cell tumor10.2VIM, MUC1
49acne10.2
50cervical cancer10.2

Graphical network of the top 20 diseases related to Malignant Peritoneal Mesothelioma:



Diseases related to malignant peritoneal mesothelioma

Symptoms for Malignant Peritoneal Mesothelioma

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Symptoms:

48 (show all 10)
  • anomalies of the abdominal wall
  • ascitis
  • acute abdominal pain/colic
  • peritoneal diseases
  • neoplasms/tumors
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • intestinal obstruction/ileus
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • edema of the legs/lower limbs
  • clotting/hemostasis disorders

HPO human phenotypes related to Malignant Peritoneal Mesothelioma:

(show all 10)
id Description Frequency HPO Source Accession
1 ascites hallmark (90%) HP:0001541
2 abdominal pain hallmark (90%) HP:0002027
3 abnormality of the peritoneum hallmark (90%) HP:0002585
4 neoplasm hallmark (90%) HP:0002664
5 abnormality of the abdominal wall hallmark (90%) HP:0004298
6 weight loss typical (50%) HP:0001824
7 abnormality of coagulation occasional (7.5%) HP:0001928
8 respiratory insufficiency occasional (7.5%) HP:0002093
9 intestinal obstruction occasional (7.5%) HP:0005214
10 edema of the lower limbs occasional (7.5%) HP:0010741

Drugs & Therapeutics for Malignant Peritoneal Mesothelioma

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Drug clinical trials:

Search ClinicalTrials for Malignant Peritoneal Mesothelioma

Search NIH Clinical Center for Malignant Peritoneal Mesothelioma

Genetic Tests for Malignant Peritoneal Mesothelioma

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Anatomical Context for Malignant Peritoneal Mesothelioma

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MalaCards organs/tissues related to Malignant Peritoneal Mesothelioma:

32
Lung, Colon, Lymph node, Testis, Liver

Animal Models for Malignant Peritoneal Mesothelioma or affiliated genes

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MGI Mouse Phenotypes related to Malignant Peritoneal Mesothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1ESR2, ESR1, MUC1, CCNE1, EGFR
2MP:00053818.9CLDN15, ESR2, ESR1, MUC1, CCNE1, EGFR
3MP:00028738.6HAS1, ESR2, MUC1, CCNE1, CALB2, BIRC5
4MP:00053798.5CLDN15, ESR2, ESR1, MUC1, CCNE1, EGFR
5MP:00107718.4EGFR, CDH11, CCNE1, MUC1, ESR1, ESR2
6MP:00053808.2EGFR, ESR1, VIM, ANGPT1, CCNE1, BIRC5
7MP:00053848.1CLDN15, ESR2, ESR1, VIM, CCNE1, BIRC5
8MP:00036317.5ESR2, ESR1, VIM, ANGPT1, CCNE1, CALB2

Publications for Malignant Peritoneal Mesothelioma

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Articles related to Malignant Peritoneal Mesothelioma:

(show top 50)    (show all 215)
idTitleAuthorsYear
1
Colonic invasion induced by malignant peritoneal mesothelioma. (24777352)
2014
2
Malignant peritoneal mesothelioma with lymph node metastasis that originated in the transverse colon. (24754918)
2014
3
Advances in malignant peritoneal mesothelioma. (25331029)
2014
4
Malignant peritoneal mesothelioma: clinicopathological characteristics of two cases. (24716080)
2014
5
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma. (23570457)
2013
6
Malignant peritoneal mesothelioma treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: is GLUT1 expression a major prognostic factor? A preliminary study. (23800898)
2013
7
Malignant peritoneal mesothelioma (MPM) who responded to rechallenge with cisplatin and pemetrexed with current literature review. (23291819)
2013
8
Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule. (23951397)
2013
9
Localized malignant peritoneal mesothelioma arising in the mesentery of the ascending colon. (22546096)
2012
10
Adjuvant bidirectional chemotherapy with intraperitoneal pemetrexed combined with intravenous Cisplatin for diffuse malignant peritoneal mesothelioma. (22927839)
2012
11
Localized malignant peritoneal mesothelioma arising in the mesentery of the ascending colon. (22691319)
2012
12
Multipotent cancer stem cells derived from human malignant peritoneal mesothelioma promote tumorigenesis. (23285196)
2012
13
Diffuse malignant peritoneal mesothelioma--an update on treatment. (22104079)
2012
14
Malignant peritoneal mesothelioma in a patient with Li-Fraumeni syndrome. (21464421)
2011
15
Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma. (20942962)
2010
16
Surgical treatment of malignant peritoneal mesothelioma: past, present, and future. (19888634)
2010
17
Recurrent malignant peritoneal mesothelioma: radiological manifestations. (19319590)
2010
18
The efficacy of the frontline platinum-based combination chemotherapy in malignant peritoneal mesothelioma. (20534685)
2010
19
Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. (19593622)
2009
20
Malignant peritoneal mesothelioma. (21160794)
2009
21
Malignant peritoneal mesothelioma: a case report. (19943603)
2009
22
Diffuse malignant peritoneal mesothelioma presenting as intestinal obstruction. (19738519)
2009
23
Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case report. (18095999)
2008
24
A case of omental mesothelioma presenting with laminar thickening of omentum-appearances of diffuse malignant peritoneal mesothelioma]. (18408444)
2008
25
Diffuse malignant peritoneal mesothelioma in a 31-year-old patient--case report. (17479682)
2007
26
Local-regional approach to diffuse malignant peritoneal mesothelioma. (18166852)
2007
27
Pathologic characterization and differential diagnosis of malignant peritoneal mesothelioma. (17506256)
2007
28
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
29
Primary malignant peritoneal mesothelioma in an incarcerated groin hernia: report of a case. (15864428)
2005
30
Congenital malignant peritoneal mesothelioma. (12599320)
2003
31
Best cases from the AFIP. Malignant peritoneal mesothelioma. (12432120)
2002
32
Pitfalls in diagnosis of early stage malignant peritoneal mesothelioma: a case report. (12140157)
2002
33
Malignant peritoneal mesothelioma. (12057102)
2001
34
Malignant peritoneal mesothelioma treated by continuous hyperthermic peritoneal perfusion chemotherapy. (10942067)
2000
35
Malignant peritoneal mesothelioma presenting with respiratory symptoms. (10823639)
2000
36
Malignant peritoneal mesothelioma deciduoid or anaplastic variant? A point to ponder. (11344619)
2000
37
Internal carotid artery occlusion in a patient with malignant peritoneal mesothelioma: is it a sign of malignancy-related thrombosis? (10768615)
2000
38
A case of malignant peritoneal mesothelioma showed complete remission with chemotherapy. (9544832)
1998
39
Importance of serum CA 125 levels in malignant peritoneal mesothelioma. (7501967)
1996
40
Malignant peritoneal mesothelioma after Thorotrast exposure. (7542832)
1995
41
Establishment and characterization of a new human mesothelioma cell line (T-85) from malignant peritoneal mesothelioma with remarkable thrombocytosis. (8581142)
1995
42
Malignant peritoneal mesothelioma in a 17-year-old boy with evidence of previous exposure to chrysotile and tremolite asbestos. (8013954)
1994
43
Diffuse malignant peritoneal mesothelioma in a young woman with a high serum level of CA125. (1710413)
1991
44
Primary malignant peritoneal mesothelioma. A report of seven cases and a review of the literature. (2241560)
1990
45
Malignant peritoneal mesothelioma in children: description of two cases and review of the literature. (4009380)
1985
46
Occurrence of malignant peritoneal mesothelioma after surgery and irradiation for cervical cancer. (6706236)
1984
47
Malignant peritoneal mesothelioma: review of 25 patients. (7258177)
1981
48
Malignant peritoneal mesothelioma following radiotherapy for seminoma of the testis. (476600)
1979
49
Malignant peritoneal mesothelioma in a child. (62511)
1976
50
Malignant peritoneal mesothelioma. (13870794)
1961

Variations for Malignant Peritoneal Mesothelioma

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Expression for genes affiliated with Malignant Peritoneal Mesothelioma

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Expression patterns in normal tissues for genes affiliated with Malignant Peritoneal Mesothelioma

Search GEO for disease gene expression data for Malignant Peritoneal Mesothelioma.

Pathways for genes affiliated with Malignant Peritoneal Mesothelioma

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Pathways related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9ESR1, ESR2
29.9ESR1, ESR2
39.9ESR1, ESR2
49.9ESR1, ESR2
5
Show member pathways
9.7ESR2, ESR1, CCNE1
6
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.7EGFR, CCNE1, ESR1
7
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.6EGFR, ESR1, ESR2
89.4EGFR, CCNE1, ESR1, ESR2
99.4CLDN3, CLDN15, EGFR
10
Show member pathways
9.2ESR2, ESR1, CCNE1, BIRC5, EGFR
11
Show member pathways
8.9CDH11, CLDN15, CLDN3
12
Show member pathways
8.6ESR2, ESR1, VIM, CDH11, EGFR
13
Show member pathways
7.8EGFR, ESR2, ESR1, VIM, MUC1, ANGPT1

Compounds for genes affiliated with Malignant Peritoneal Mesothelioma

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Compounds related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1butylparaben4410.2ESR2, ESR1
22,4,6-trichloro-4-biphenylol4410.2ESR1, ESR2
3isobutylparaben4410.2ESR1, ESR2
4isopropylparaben4410.1ESR1, ESR2
54-octylphenol4410.1ESR1, ESR2
6r,r-thc2810.1ESR2, ESR1
7methylparaben4410.1ESR2, ESR1
8ly 1170184410.1ESR2, ESR1
9anastrozole44 50 1112.0ESR2, ESR1, EGFR
10daidzein4410.0ESR2, ESR1, BIRC5
11exemestane44 50 61 1113.0ESR2, ESR1, EGFR
12alkylating agents5010.0EGFR, ESR1
13lapatinib44 50 1112.0BIRC5, EGFR, ESR1
14lasofoxifene4410.0ESR1, ESR2
15taxane4410.0ESR1, EGFR, BIRC5
16fulvestrant44 50 28 1113.0ESR2, EGFR, ESR1
17letrozole44 50 61 1112.9ESR2, EGFR, ESR1
1817alpha estradiol449.9ESR2, ESR1
19zeranol449.9ESR1, ESR2
20mucicarmine449.9VIM, MUC1, CALB2
21trastuzumab44 50 1111.8EGFR, ESR1, MUC1, BIRC5
22mifepristone44 28 61 1112.8MUC1, ESR1, BIRC5, ESR2
23thymidylate449.8VIM, ESR2, BIRC5, EGFR
24dihydrotestosterone44 28 24 1112.7MUC1, VIM, ESR1, ESR2
25gefitinib44 50 1111.6BIRC5, ESR2, ESR1, VIM, EGFR
26actinomycin d449.5ESR1, BIRC5, ESR2, VIM, MUC1
27rapamycin449.5ANGPT1, VIM, EGFR, ESR2, BIRC5
28bicalutamide44 61 1111.3EGFR, ESR1, ESR2
29tamoxifen44 50 28 1112.3EGFR, BIRC5, VIM, ESR2, MUC1, ESR1
304-hydroxytamoxifen449.3HMGB1, ESR2, EGFR, ESR1, VIM
31b 723449.3CALB2, MUC16, VIM, MUC1
32progestin449.3ESR2, EGFR, ESR1, VIM, MUC1, ANGPT1
33hematoxylin449.3MUC1, MUC16, CALB2, VIM
34butyrate449.1HMGB1, BIRC5, CALB2, VIM, MUC1
35hyaluronic acid44 2410.1VIM, HAS1, MUC1, MUC16, CALB2
36genistein44 28 61 2 24 1114.0EGFR, ESR2, BIRC5, VIM, ESR1
37estradiol44 24 1111.0VIM, BIRC5, MUC1, MUC16, ESR2, ESR1
38retinoic acid44 249.8EGFR, ESR1, VIM, MUC1, BIRC5, HMGB1
39cisplatin44 50 61 1111.7ESR1, MUC16, MUC1, BIRC5, HMGB1, EGFR
40dexamethasone44 50 28 1111.6ESR2, MUC16, MUC1, VIM, HMGB1, BIRC5
41doxorubicin44 50 1110.6BIRC5, EGFR, MUC16, VIM, ESR1, ESR2
42paclitaxel44 50 1110.4VIM, MUC16, ANGPT1, CALB2, BIRC5, EGFR
43serine448.2HMGB1, ESR2, MUC16, MUC1, CCNE1, BIRC5
44steroid448.1CALB2, ESR2, ESR1, MUC16, ANGPT1, HMGB1
45vegf447.9BIRC5, ANGPT1, MUC1, MUC16, ESR1, EGFR
46paraffin447.9ESR1, MUC16, BIRC5, MUC1, ANGPT1, CALB2
47testosterone44 61 24 1110.7MUC1, MUC16, VIM, ESR1, ESR2, HMGB1
48calcium44 50 24 1110.2CCNE1, ANGPT1, CLDN3, CLDN15, MUC1, CALB2
49estrogen447.1HMGB1, CCNE1, ESR2, ESR1, VIM, MUC16
50progesterone44 28 61 24 1110.6CDH11, VIM, MUC16, EGFR, HMGB1, BIRC5

GO Terms for genes affiliated with Malignant Peritoneal Mesothelioma

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Cellular components related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.3EGFR, CDH11, ANGPT1, MUC16, VIM, ESR1

Biological processes related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:06006510.1ESR1, ESR2
2vagina developmentGO:06006810.0ESR1, ESR2
3cellular response to estradiol stimulusGO:07139210.0ESR1, EGFR
4intracellular estrogen receptor signaling pathwayGO:0305209.9ESR1, ESR2
5positive regulation of nitric oxide biosynthetic processGO:0454299.9EGFR, ESR1
6calcium-independent cell-cell adhesionGO:0163389.6CLDN15, CLDN3
7positive chemotaxisGO:0509189.3HMGB1, ANGPT1
8ossificationGO:0015039.2EGFR, CDH11, KAZALD1

Molecular functions related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.1ESR2, ESR1
2estrogen receptor activityGO:03028410.0ESR1, ESR2
3steroid bindingGO:0054969.9ESR1, ESR2
4nitric-oxide synthase regulator activityGO:0302359.9ESR1, EGFR
5core promoter sequence-specific DNA bindingGO:0010469.8ESR1, ESR2
6enzyme bindingGO:0198999.4EGFR, BIRC5, ESR1, ESR2
7identical protein bindingGO:0428028.8EGFR, BIRC5, VIM, ESR1, CLDN15, CLDN3
8protein bindingGO:0055156.8TMEM30B, ESR2, ESR1, VIM, MUC16, MUC1

Products for genes affiliated with Malignant Peritoneal Mesothelioma

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Sources for Malignant Peritoneal Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet