MCID: MLG002
MIFTS: 50

Malignant Peritoneal Mesothelioma malady

Cancer diseases, Rare diseases categories

Summaries for Malignant Peritoneal Mesothelioma

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MalaCards based summary: Malignant Peritoneal Mesothelioma, also known as diffuse malignant peritoneal mesothelioma, is related to mesothelioma and li-fraumeni syndrome, and has symptoms including ascites, abdominal pain and abnormality of the peritoneum. An important gene associated with Malignant Peritoneal Mesothelioma is HAS1 (hyaluronan synthase 1), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and MNAR-PELP1 and Estrogen Receptor Interaction. The compounds isobutylparaben and 2,4,6-trichloro-4-biphenylol have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and lymph node, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Malignant Peritoneal Mesothelioma

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Sources:
60UMLS, 11DISEASES, 47Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Malignant Peritoneal Mesothelioma, Aliases & Descriptions:

Name: Malignant Peritoneal Mesothelioma 11 47
Diffuse Malignant Peritoneal Mesothelioma 47
 
Primary Malignant Peritoneal Mesothelioma 47
Malignant Mesothelioma of Peritoneum 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 47 
Rare tumors


Characteristics (Orphanet epidemiological data):

47
malignant peritoneal mesothelioma:
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/1000000 (France),1-9/100000 (Europe),1-9/1000000 (Italy); Age of onset: Adult; Age of death: adult


External Ids:

Orphanet47 168811
ICD10 via Orphanet26 C45.1
UMLS via Orphanet61 C0346109

Related Diseases for Malignant Peritoneal Mesothelioma

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Diseases in the Peritoneal Mesothelioma family:

Benign Peritoneal Mesothelioma malignant peritoneal mesothelioma

Diseases related to Malignant Peritoneal Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1mesothelioma32.1CALB2, MUC1, MUC16, VIM, CLDN3
2li-fraumeni syndrome30.3ESR2, ESR1
3melanoma29.7VIM, ANGPT1, CALB2, BIRC5, HMGB1
4adenocarcinoma28.0CLDN3, ESR2, ESR1, VIM, MUC16, MUC1
5peritoneal mesothelioma11.4
6peritonitis11.4
7hidradenoma10.5MUC1
8syringoma10.5MUC1
9ovarian serous cystadenocarcinoma10.5MUC16
10pericardial effusion10.5MUC16
11ovarian cystadenoma10.5MUC16
12glomus tumor10.5VIM
13renal cell carcinoma10.4EGFR
14adenomatoid tumor10.4CALB2, VIM
15cystadenocarcinoma10.4MUC1, MUC16
16clear cell ependymoma10.4MUC1, VIM
17sertoli-leydig cell tumor10.4MUC1, CALB2
18mesenchymal chondrosarcoma10.4VIM, MUC1
19progesterone resistance10.4ESR1
20malignant pleural mesothelioma10.4KAZALD1, CALB2
21spindle cell carcinoma10.4MUC1, VIM
22thymic carcinoma10.4MUC1, CALB2
23spindle cell sarcoma10.4VIM, MUC1
24giant cell glioblastoma10.4EGFR
25intestinal obstruction10.4
26seminoma10.4
27granular cell tumor10.4VIM, CALB2
28adenofibroma10.4MUC16, CALB2
29mucinous cystadenocarcinoma10.4MUC16, MUC1
30adenosarcoma10.4ESR1
31papillary adenocarcinoma10.4MUC16, MUC1
32dermatofibrosarcoma protuberans10.4VIM, MUC1
33secretory meningioma10.4VIM, MUC1
34perineurioma10.4MUC1, VIM
35rhabdoid tumor10.4MUC1, VIM
36hemangiopericytoma10.3MUC1, VIM
37ovarian disease10.3ESR1
38malignant mixed mullerian tumor10.3MUC1, VIM
39chordoma10.3MUC1, VIM
40ovarian cyst10.3ESR2, MUC16
41sertoli cell tumor10.3CALB2, MUC1, VIM
42sex cord-gonadal stromal tumor10.3VIM, MUC1, CALB2
43sarcoma, synovial10.3CALB2, MUC1, VIM
44neurilemmoma10.3VIM, MUC1, CALB2
45malignant peripheral nerve sheath tumor10.3VIM, MUC1
46fibroma10.3CALB2, MUC16, VIM
47mammary paget's disease10.3MUC1, ESR1
48giant cell tumor10.2VIM, MUC1
49hepatocellular carcinoma10.2
50acne10.2

Graphical network of the top 20 diseases related to Malignant Peritoneal Mesothelioma:



Diseases related to malignant peritoneal mesothelioma

Symptoms for Malignant Peritoneal Mesothelioma

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Symptoms:

 47 (show all 10)
  • anomalies of the abdominal wall
  • ascitis
  • acute abdominal pain/colic
  • peritoneal diseases
  • neoplasms/tumors
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • intestinal obstruction/ileus
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • edema of the legs/lower limbs
  • clotting/hemostasis disorders

HPO human phenotypes related to Malignant Peritoneal Mesothelioma:

(show all 10)
id Description Frequency HPO Source Accession
1 ascites hallmark (90%) HP:0001541
2 abdominal pain hallmark (90%) HP:0002027
3 abnormality of the peritoneum hallmark (90%) HP:0002585
4 neoplasm hallmark (90%) HP:0002664
5 abnormality of the abdominal wall hallmark (90%) HP:0004298
6 weight loss typical (50%) HP:0001824
7 abnormality of coagulation occasional (7.5%) HP:0001928
8 respiratory insufficiency occasional (7.5%) HP:0002093
9 intestinal obstruction occasional (7.5%) HP:0005214
10 edema of the lower limbs occasional (7.5%) HP:0010741

Drugs & Therapeutics for Malignant Peritoneal Mesothelioma

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Drug clinical trials:

Search ClinicalTrials for Malignant Peritoneal Mesothelioma

Search NIH Clinical Center for Malignant Peritoneal Mesothelioma

Genetic Tests for Malignant Peritoneal Mesothelioma

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Anatomical Context for Malignant Peritoneal Mesothelioma

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MalaCards organs/tissues related to Malignant Peritoneal Mesothelioma:

31
Lung, Colon, Lymph node, Testis, Liver

Animal Models for Malignant Peritoneal Mesothelioma or affiliated genes

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MGI Mouse Phenotypes related to Malignant Peritoneal Mesothelioma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1ESR2, ESR1, MUC1, CCNE1, EGFR
2MP:00053818.9CLDN15, ESR2, ESR1, MUC1, CCNE1, EGFR
3MP:00028738.6HAS1, ESR2, MUC1, CCNE1, CALB2, BIRC5
4MP:00053798.5CLDN15, ESR2, ESR1, MUC1, CCNE1, EGFR
5MP:00107718.4EGFR, CDH11, CCNE1, MUC1, ESR1, ESR2
6MP:00053808.2EGFR, ESR1, VIM, ANGPT1, CCNE1, BIRC5
7MP:00053848.1CLDN15, ESR2, ESR1, VIM, CCNE1, BIRC5
8MP:00036317.5ESR2, ESR1, VIM, ANGPT1, CCNE1, CALB2

Publications for Malignant Peritoneal Mesothelioma

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Articles related to Malignant Peritoneal Mesothelioma:

(show top 50)    (show all 218)
idTitleAuthorsYear
1
Unusual Appearance of Malignant Peritoneal Mesothelioma. (25793652)
2015
2
Colonic invasion induced by malignant peritoneal mesothelioma. (24777352)
2014
3
Malignant peritoneal mesothelioma with lymph node metastasis that originated in the transverse colon. (24754918)
2014
4
Advances in malignant peritoneal mesothelioma. (25331029)
2014
5
Malignant peritoneal mesothelioma: clinicopathological characteristics of two cases. (24716080)
2014
6
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma. (23570457)
2013
7
Malignant peritoneal mesothelioma treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: is GLUT1 expression a major prognostic factor? A preliminary study. (23800898)
2013
8
Malignant peritoneal mesothelioma (MPM) who responded to rechallenge with cisplatin and pemetrexed with current literature review. (23291819)
2013
9
Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule. (23951397)
2013
10
Localized malignant peritoneal mesothelioma arising in the mesentery of the ascending colon. (22546096)
2012
11
Adjuvant bidirectional chemotherapy with intraperitoneal pemetrexed combined with intravenous Cisplatin for diffuse malignant peritoneal mesothelioma. (22927839)
2012
12
Localized malignant peritoneal mesothelioma arising in the mesentery of the ascending colon. (22691319)
2012
13
Multipotent cancer stem cells derived from human malignant peritoneal mesothelioma promote tumorigenesis. (23285196)
2012
14
Malignant peritoneal mesothelioma in a patient with Li-Fraumeni syndrome. (21464421)
2011
15
Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma. (20942962)
2010
16
Surgical treatment of malignant peritoneal mesothelioma: past, present, and future. (19888634)
2010
17
Recurrent malignant peritoneal mesothelioma: radiological manifestations. (19319590)
2010
18
The efficacy of the frontline platinum-based combination chemotherapy in malignant peritoneal mesothelioma. (20534685)
2010
19
Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. (19593622)
2009
20
Malignant peritoneal mesothelioma. (21160794)
2009
21
Malignant peritoneal mesothelioma: a case report. (19943603)
2009
22
Diffuse malignant peritoneal mesothelioma presenting as intestinal obstruction. (19738519)
2009
23
Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case report. (18095999)
2008
24
A case of omental mesothelioma presenting with laminar thickening of omentum-appearances of diffuse malignant peritoneal mesothelioma]. (18408444)
2008
25
Diffuse malignant peritoneal mesothelioma in a 31-year-old patient--case report. (17479682)
2007
26
Local-regional approach to diffuse malignant peritoneal mesothelioma. (18166852)
2007
27
Pathologic characterization and differential diagnosis of malignant peritoneal mesothelioma. (17506256)
2007
28
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
29
Dramatic tumour response to pemetrexed single-agent in an elderly patient with malignant peritoneal mesothelioma: a case report. (17176466)
2006
30
Primary malignant peritoneal mesothelioma in an incarcerated groin hernia: report of a case. (15864428)
2005
31
Congenital malignant peritoneal mesothelioma. (12599320)
2003
32
Best cases from the AFIP. Malignant peritoneal mesothelioma. (12432120)
2002
33
Pitfalls in diagnosis of early stage malignant peritoneal mesothelioma: a case report. (12140157)
2002
34
Malignant peritoneal mesothelioma. (12057102)
2001
35
Malignant peritoneal mesothelioma treated by continuous hyperthermic peritoneal perfusion chemotherapy. (10942067)
2000
36
Malignant peritoneal mesothelioma presenting with respiratory symptoms. (10823639)
2000
37
Malignant peritoneal mesothelioma deciduoid or anaplastic variant? A point to ponder. (11344619)
2000
38
Internal carotid artery occlusion in a patient with malignant peritoneal mesothelioma: is it a sign of malignancy-related thrombosis? (10768615)
2000
39
A case of malignant peritoneal mesothelioma showed complete remission with chemotherapy. (9544832)
1998
40
Importance of serum CA 125 levels in malignant peritoneal mesothelioma. (7501967)
1996
41
Establishment and characterization of a new human mesothelioma cell line (T-85) from malignant peritoneal mesothelioma with remarkable thrombocytosis. (8581142)
1995
42
Malignant peritoneal mesothelioma in a 17-year-old boy with evidence of previous exposure to chrysotile and tremolite asbestos. (8013954)
1994
43
Diffuse malignant peritoneal mesothelioma in a young woman with a high serum level of CA125. (1710413)
1991
44
Primary malignant peritoneal mesothelioma. A report of seven cases and a review of the literature. (2241560)
1990
45
Malignant peritoneal mesothelioma in children: description of two cases and review of the literature. (4009380)
1985
46
Occurrence of malignant peritoneal mesothelioma after surgery and irradiation for cervical cancer. (6706236)
1984
47
Malignant peritoneal mesothelioma: review of 25 patients. (7258177)
1981
48
Malignant peritoneal mesothelioma following radiotherapy for seminoma of the testis. (476600)
1979
49
Malignant peritoneal mesothelioma in a child. (62511)
1976
50
Malignant peritoneal mesothelioma. (13870794)
1961

Variations for Malignant Peritoneal Mesothelioma

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Expression for genes affiliated with Malignant Peritoneal Mesothelioma

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Search GEO for disease gene expression data for Malignant Peritoneal Mesothelioma.

Pathways for genes affiliated with Malignant Peritoneal Mesothelioma

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Pathways related to Malignant Peritoneal Mesothelioma according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9ESR1, ESR2
29.9ESR1, ESR2
39.9ESR1, ESR2
49.9ESR1, ESR2
5
Show member pathways
9.7ESR2, ESR1, CCNE1
6
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway58
9.7EGFR, CCNE1, ESR1
7
Show member pathways
Development Ligand independent activation of ESR1 and ESR258
9.6EGFR, ESR1, ESR2
89.4EGFR, CCNE1, ESR1, ESR2
99.4CLDN3, CLDN15, EGFR
10
Show member pathways
9.2ESR2, ESR1, CCNE1, BIRC5, EGFR
11
Show member pathways
8.9CDH11, CLDN15, CLDN3
12
Show member pathways
8.6ESR2, ESR1, VIM, CDH11, EGFR
13
Show member pathways
7.8EGFR, ESR2, ESR1, VIM, MUC1, ANGPT1

Compounds for genes affiliated with Malignant Peritoneal Mesothelioma

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Compounds related to Malignant Peritoneal Mesothelioma according to GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1isobutylparaben4310.2ESR2, ESR1
22,4,6-trichloro-4-biphenylol4310.2ESR2, ESR1
3ly 1170184310.2ESR2, ESR1
4isopropylparaben4310.1ESR1, ESR2
5r,r-thc2810.1ESR2, ESR1
6methylparaben4310.1ESR2, ESR1
7butylparaben4310.1ESR2, ESR1
84-octylphenol4310.1ESR2, ESR1
917alpha estradiol4310.0ESR2, ESR1
10anastrozole43 49 1212.0ESR1, ESR2, EGFR
11daidzein4310.0ESR1, BIRC5, ESR2
12exemestane43 49 59 1213.0EGFR, ESR2, ESR1
13lapatinib43 49 1212.0ESR1, BIRC5, EGFR
14taxane4310.0EGFR, ESR1, BIRC5
15fulvestrant43 49 28 1213.0EGFR, ESR1, ESR2
16alkylating agents4910.0EGFR, ESR1
17letrozole43 49 59 1212.9ESR1, EGFR, ESR2
18lasofoxifene439.9ESR1, ESR2
194-tert-octylphenol439.9ESR2, ESR1
20mucicarmine439.9CALB2, VIM, MUC1
21trastuzumab43 49 1211.8ESR1, BIRC5, EGFR, MUC1
22mifepristone43 28 59 1212.8ESR2, BIRC5, MUC1, ESR1
23thymidylate439.8EGFR, BIRC5, ESR2, VIM
24dihydrotestosterone43 28 24 1212.7ESR1, VIM, MUC1, ESR2
25gefitinib43 49 1211.6BIRC5, ESR2, ESR1, VIM, EGFR
26actinomycin d439.5MUC1, ESR1, BIRC5, VIM, ESR2
27rapamycin439.5ESR2, ANGPT1, EGFR, VIM, BIRC5
28bicalutamide43 59 1211.3ESR2, ESR1, EGFR
29tamoxifen43 49 28 1212.3EGFR, BIRC5, VIM, ESR2, MUC1, ESR1
304-hydroxytamoxifen439.3HMGB1, ESR2, EGFR, ESR1, VIM
31b 723439.3CALB2, MUC16, VIM, MUC1
32progestin439.3ESR2, EGFR, ESR1, VIM, MUC1, ANGPT1
33hematoxylin439.3MUC1, VIM, MUC16, CALB2
34butyrate439.1HMGB1, BIRC5, MUC1, VIM, CALB2
35hyaluronic acid43 2410.1VIM, HAS1, MUC1, MUC16, CALB2
36genistein43 28 59 2 24 1214.0VIM, BIRC5, EGFR, ESR2, ESR1
37estradiol43 24 1211.0MUC16, ESR2, ESR1, BIRC5, MUC1, VIM
38retinoic acid43 249.8MUC1, VIM, ESR1, ESR2, HMGB1, EGFR
39cisplatin43 49 59 1211.7ESR1, HMGB1, MUC1, EGFR, BIRC5, MUC16
40dexamethasone43 49 28 1211.6ESR2, MUC1, MUC16, BIRC5, HMGB1, VIM
41doxorubicin43 49 1210.6BIRC5, EGFR, MUC16, VIM, ESR1, ESR2
42paclitaxel43 49 1210.4VIM, MUC16, ANGPT1, CALB2, BIRC5, EGFR
43serine438.2ESR2, MUC16, CCNE1, MUC1, VIM, BIRC5
44steroid438.1CALB2, BIRC5, ANGPT1, MUC16, ESR1, HMGB1
45vegf437.9BIRC5, ANGPT1, MUC1, MUC16, ESR1, EGFR
46paraffin437.9ESR1, MUC16, BIRC5, MUC1, ANGPT1, CALB2
47testosterone43 59 24 1210.7MUC1, MUC16, VIM, ESR1, ESR2, HMGB1
48calcium43 49 24 1210.2CCNE1, ANGPT1, MUC1, CLDN15, BIRC5, CLDN3
49estrogen437.1HMGB1, CCNE1, ESR2, ESR1, VIM, MUC16
50progesterone43 28 59 24 1210.6CDH11, VIM, MUC16, EGFR, HMGB1, BIRC5

GO Terms for genes affiliated with Malignant Peritoneal Mesothelioma

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Cellular components related to Malignant Peritoneal Mesothelioma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:00058867.3EGFR, CDH11, ANGPT1, MUC16, VIM, ESR1

Biological processes related to Malignant Peritoneal Mesothelioma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:006006510.1ESR1, ESR2
2vagina developmentGO:006006810.0ESR1, ESR2
3cellular response to estradiol stimulusGO:007139210.0ESR1, EGFR
4intracellular estrogen receptor signaling pathwayGO:00305209.9ESR1, ESR2
5positive regulation of nitric oxide biosynthetic processGO:00454299.9EGFR, ESR1
6calcium-independent cell-cell adhesionGO:00163389.6CLDN15, CLDN3
7positive chemotaxisGO:00509189.3HMGB1, ANGPT1
8ossificationGO:00015039.2EGFR, CDH11, KAZALD1

Molecular functions related to Malignant Peritoneal Mesothelioma according to GeneCards Suite gene sharing:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:003405610.1ESR2, ESR1
2estrogen receptor activityGO:003028410.0ESR1, ESR2
3steroid bindingGO:00054969.9ESR1, ESR2
4nitric-oxide synthase regulator activityGO:00302359.9ESR1, EGFR
5core promoter sequence-specific DNA bindingGO:00010469.8ESR1, ESR2
6enzyme bindingGO:00198999.4EGFR, BIRC5, ESR1, ESR2
7identical protein bindingGO:00428028.8EGFR, BIRC5, VIM, ESR1, CLDN15, CLDN3
8protein bindingGO:00055156.8TMEM30B, ESR2, ESR1, VIM, MUC16, MUC1

Products for genes affiliated with Malignant Peritoneal Mesothelioma

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Sources for Malignant Peritoneal Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet