MCID: MLG002
MIFTS: 60

Malignant Peritoneal Mesothelioma malady

Cancer diseases, Rare diseases categories
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Summaries for Malignant Peritoneal Mesothelioma

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33MalaCards
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MalaCards: Malignant Peritoneal Mesothelioma, also known as malignant mesothelioma of peritoneum, is related to malignant mesothelioma and papillary adenocarcinoma, and has symptoms including edema of the legs/lower limbs, peritoneal diseases and anomalies of the abdominal wall. An important gene associated with Malignant Peritoneal Mesothelioma is HAS1 (hyaluronan synthase 1), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and MNAR-PELP1 and Estrogen Receptor Interaction. The compounds butylparaben and 2,4,6-trichloro-4-biphenylol have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and lymph node, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Malignant Peritoneal Mesothelioma

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8Disease Ontology, 10DISEASES, 49Orphanet, 62UMLS, 58SNOMED-CT, 40NCIt, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 26ICD10 via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Orphanet: 49 
Rare tumors


Characteristics (Orphanet epidemiological data):

49
malignant peritoneal mesothelioma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

malignant peritoneal mesothelioma 8 10 49
malignant mesothelioma of peritoneum 8 62
advanced malignant mesothelioma of peritoneum 8
advanced malignant peritoneal mesothelioma 8
advanced peritoneal malignant mesothelioma 62
diffuse malignant peritoneal mesothelioma 49
primary malignant peritoneal mesothelioma 49
peritoneal malignant mesothelioma 8


External Ids:

Disease Ontology8 DOID:1788
NCIt40 C9350
SNOMED-CT via Orphanet59 109853004
UMLS via Orphanet63 C0346109
ICD10 via Orphanet26 C45.1
ICD1025 C45.1

Related Diseases for Malignant Peritoneal Mesothelioma

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17GeneCards, 18GeneDecks
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Diseases in the Malignant Peritoneal Mesothelioma family:

Benign Peritoneal Mesothelioma Peritoneal Mesothelioma

Diseases related to Malignant Peritoneal Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mesothelioma31.1CALB2, MUC1, MUC16, VIM
2papillary adenocarcinoma30.4MUC16, MUC1
3li-fraumeni syndrome30.3ESR2, ESR1
4melanoma30.2VIM, ANGPT1, CALB2, BIRC5, HMGB1
5ovarian cancer30.0CLDN3, ESR2, ESR1, MUC16, MUC1, ANGPT1
6adenocarcinoma29.8CLDN3, ESR2, ESR1, VIM, MUC16, MUC1
7peritoneal mesothelioma11.4
8peritonitis11.4
9intestinal obstruction10.4
10seminoma10.4
11thrombocytosis10.2
12thrombotic thrombocytopenic purpura10.2
13lymphangitis10.2
14appendicitis10.2
15asbestosis10.2
16carotid artery occlusion10.2
17duodenitis10.2
18pseudomyxoma peritonei10.2
19acne10.2
20cervical cancer10.2
21cervicitis10.2
22hepatocellular carcinoma10.2
23inflammatory bowel disease10.2
24laryngeal carcinoma10.2
25laryngitis10.2
26nephrotic syndrome10.2
27purpura10.2
28ocular melanoma10.2
29hidradenoma10.1MUC1
30syringoma10.1MUC1
31ovarian serous cystadenocarcinoma10.1MUC16
32pericardial effusion10.1MUC16
33ovarian cystadenoma10.1MUC16
34glomus tumor10.1VIM
35kidney cancer10.1EGFR
36adenomatoid tumor10.1CALB2, VIM
37cystadenocarcinoma10.1MUC1, MUC16
38clear cell ependymoma10.1MUC1, VIM
39sertoli-leydig cell tumor10.1MUC1, CALB2
40mesenchymal chondrosarcoma10.1VIM, MUC1
41progesterone resistance10.1ESR1
42malignant pleural mesothelioma10.1KAZALD1, CALB2
43spindle cell carcinoma10.1MUC1, VIM
44thymus cancer10.1MUC1, CALB2
45spindle cell sarcoma10.1VIM, MUC1
46giant cell glioblastoma10.1EGFR
47granular cell tumor10.1VIM, CALB2
48adenofibroma10.1MUC16, CALB2
49mucinous cystadenocarcinoma10.1MUC16, MUC1
50adenosarcoma10.1ESR1

Graphical network of the top 20 diseases related to Malignant Peritoneal Mesothelioma:



Diseases related to malignant peritoneal mesothelioma

Symptoms for Malignant Peritoneal Mesothelioma

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49Orphanet
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Symptoms:

49 (show all 10)
  • edema of the legs/lower limbs
  • peritoneal diseases
  • anomalies of the abdominal wall
  • clotting/hemostasis disorders
  • neoplasms/tumors
  • intestinal obstruction/ileus
  • acute abdominal pain/colic
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • ascitis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction

Drugs & Therapeutics for Malignant Peritoneal Mesothelioma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Malignant Peritoneal Mesothelioma

Search NIH Clinical Center for Malignant Peritoneal Mesothelioma

Genetic Tests for Malignant Peritoneal Mesothelioma

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Anatomical Context for Malignant Peritoneal Mesothelioma

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33MalaCards
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MalaCards organs/tissues related to Malignant Peritoneal Mesothelioma:

33
Lung, Colon, Lymph node, Testis, Liver

Animal Models for Malignant Peritoneal Mesothelioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Malignant Peritoneal Mesothelioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1ESR2, ESR1, MUC1, CCNE1, EGFR
2MP:00053818.9CLDN15, ESR2, ESR1, MUC1, CCNE1, EGFR
3MP:00028738.6HAS1, ESR2, MUC1, CCNE1, CALB2, BIRC5
4MP:00053798.5CLDN15, ESR2, ESR1, MUC1, CCNE1, EGFR
5MP:00107718.4EGFR, CDH11, CCNE1, MUC1, ESR1, ESR2
6MP:00053808.2EGFR, ESR1, VIM, ANGPT1, CCNE1, BIRC5
7MP:00053848.1CLDN15, ESR2, ESR1, VIM, CCNE1, BIRC5
8MP:00036317.5ESR2, ESR1, VIM, ANGPT1, CCNE1, CALB2

Publications for Malignant Peritoneal Mesothelioma

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52PubMed
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Articles related to Malignant Peritoneal Mesothelioma:

(show top 50)    (show all 196)
idTitleAuthorsYear
1
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma. (23570457)
2013
2
Malignant peritoneal mesothelioma treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: is GLUT1 expression a major prognostic factor? A preliminary study. (23800898)
2013
3
Malignant peritoneal mesothelioma (MPM) who responded to rechallenge with cisplatin and pemetrexed with current literature review. (23291819)
2013
4
Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule. (23951397)
2013
5
Clinical significance of serum angiopoietin-1 in malignant peritoneal mesothelioma. (24010773)
2013
6
Localized malignant peritoneal mesothelioma arising in the mesentery of the ascending colon. (22546096)
2012
7
Adjuvant bidirectional chemotherapy with intraperitoneal pemetrexed combined with intravenous Cisplatin for diffuse malignant peritoneal mesothelioma. (22927839)
2012
8
Localized malignant peritoneal mesothelioma arising in the mesentery of the ascending colon. (22691319)
2012
9
Multipotent cancer stem cells derived from human malignant peritoneal mesothelioma promote tumorigenesis. (23285196)
2012
10
Diffuse malignant peritoneal mesothelioma--an update on treatment. (22104079)
2012
11
Malignant peritoneal mesothelioma in a patient with Li-Fraumeni syndrome. (21464421)
2011
12
Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma. (20942962)
2010
13
Surgical treatment of malignant peritoneal mesothelioma: past, present, and future. (19888634)
2010
14
Recurrent malignant peritoneal mesothelioma: radiological manifestations. (19319590)
2010
15
The efficacy of the frontline platinum-based combination chemotherapy in malignant peritoneal mesothelioma. (20534685)
2010
16
Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. (19593622)
2009
17
Malignant peritoneal mesothelioma. (21160794)
2009
18
Malignant peritoneal mesothelioma: a case report. (19943603)
2009
19
Diffuse malignant peritoneal mesothelioma presenting as intestinal obstruction. (19738519)
2009
20
Malignant peritoneal mesothelioma: contribution and limitation of imaging for its diagnosis. (19999328)
2009
21
Acne inversa complicated by squamous cell carcinoma in association with diffuse malignant peritoneal mesothelioma arising in the absence of predisposing factors: a case report. (18095999)
2008
22
A case of omental mesothelioma presenting with laminar thickening of omentum-appearances of diffuse malignant peritoneal mesothelioma]. (18408444)
2008
23
Diffuse malignant peritoneal mesothelioma in a 31-year-old patient--case report. (17479682)
2007
24
Local-regional approach to diffuse malignant peritoneal mesothelioma. (18166852)
2007
25
Pathologic characterization and differential diagnosis of malignant peritoneal mesothelioma. (17506256)
2007
26
Prognostic indicators for patients undergoing cytoreductive surgery and perioperative intraperitoneal chemotherapy for diffuse malignant peritoneal mesothelioma. (17039392)
2007
27
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
28
Dramatic tumour response to pemetrexed single-agent in an elderly patient with malignant peritoneal mesothelioma: a case report. (17176466)
2006
29
Congenital malignant peritoneal mesothelioma. (12599320)
2003
30
Best cases from the AFIP. Malignant peritoneal mesothelioma. (12432120)
2002
31
Pitfalls in diagnosis of early stage malignant peritoneal mesothelioma: a case report. (12140157)
2002
32
Malignant peritoneal mesothelioma. (12057102)
2001
33
Malignant peritoneal mesothelioma treated by continuous hyperthermic peritoneal perfusion chemotherapy. (10942067)
2000
34
Malignant peritoneal mesothelioma presenting with respiratory symptoms. (10823639)
2000
35
Malignant peritoneal mesothelioma deciduoid or anaplastic variant? A point to ponder. (11344619)
2000
36
Internal carotid artery occlusion in a patient with malignant peritoneal mesothelioma: is it a sign of malignancy-related thrombosis? (10768615)
2000
37
A case of malignant peritoneal mesothelioma showed complete remission with chemotherapy. (9544832)
1998
38
Importance of serum CA 125 levels in malignant peritoneal mesothelioma. (7501967)
1996
39
Malignant peritoneal mesothelioma following asbestos exposure. (9216805)
1996
40
Malignant peritoneal mesothelioma after Thorotrast exposure. (7542832)
1995
41
Establishment and characterization of a new human mesothelioma cell line (T-85) from malignant peritoneal mesothelioma with remarkable thrombocytosis. (8581142)
1995
42
Malignant peritoneal mesothelioma in a 17-year-old boy with evidence of previous exposure to chrysotile and tremolite asbestos. (8013954)
1994
43
Diffuse malignant peritoneal mesothelioma in a young woman with a high serum level of CA125. (1710413)
1991
44
Primary malignant peritoneal mesothelioma. A report of seven cases and a review of the literature. (2241560)
1990
45
Malignant peritoneal mesothelioma in children: description of two cases and review of the literature. (4009380)
1985
46
Occurrence of malignant peritoneal mesothelioma after surgery and irradiation for cervical cancer. (6706236)
1984
47
Malignant peritoneal mesothelioma: review of 25 patients. (7258177)
1981
48
Malignant peritoneal mesothelioma following radiotherapy for seminoma of the testis. (476600)
1979
49
Malignant peritoneal mesothelioma in a child. (62511)
1976
50
Malignant peritoneal mesothelioma. (13870794)
1961

Variations for Malignant Peritoneal Mesothelioma

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Expression for genes affiliated with Malignant Peritoneal Mesothelioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Peritoneal Mesothelioma

Search GEO for disease gene expression data for Malignant Peritoneal Mesothelioma.

Pathways for genes affiliated with Malignant Peritoneal Mesothelioma

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50PathCards, 51PharmGKB, 55Reactome, 53QIAGEN, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG
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Pathways related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9ESR1, ESR2
29.9ESR1, ESR2
39.9ESR1, ESR2
49.9ESR1, ESR2
5
Show member pathways
9.7ESR2, ESR1, CCNE1
6
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.7EGFR, CCNE1, ESR1
7
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.6EGFR, ESR1, ESR2
89.4EGFR, CCNE1, ESR1, ESR2
99.4CLDN3, CLDN15, EGFR
10
Show member pathways
9.2ESR2, ESR1, CCNE1, BIRC5, EGFR
11
Show member pathways
8.9CDH11, CLDN15, CLDN3
12
Show member pathways
8.6ESR2, ESR1, VIM, CDH11, EGFR
13
Show member pathways
7.8EGFR, ESR2, ESR1, VIM, MUC1, ANGPT1

Compounds for genes affiliated with Malignant Peritoneal Mesothelioma

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 123)
idCompoundScoreTop Affiliating Genes
1butylparaben4510.2ESR2, ESR1
22,4,6-trichloro-4-biphenylol4510.2ESR1, ESR2
3isobutylparaben4510.2ESR1, ESR2
4isopropylparaben4510.1ESR1, ESR2
54-octylphenol4510.1ESR1, ESR2
6r,r-thc2910.1ESR2, ESR1
7methylparaben4510.1ESR2, ESR1
8ly 1170184510.1ESR2, ESR1
9anastrozole45 51 1112.0ESR2, ESR1, EGFR
10daidzein4510.0ESR2, ESR1, BIRC5
11exemestane45 51 61 1113.0ESR2, ESR1, EGFR
12alkylating agents5110.0EGFR, ESR1
13lapatinib45 51 1112.0BIRC5, EGFR, ESR1
14lasofoxifene4510.0ESR1, ESR2
15taxane4510.0ESR1, EGFR, BIRC5
16fulvestrant45 51 29 1113.0ESR2, EGFR, ESR1
17letrozole45 51 61 1112.9ESR2, EGFR, ESR1
1817alpha estradiol459.9ESR2, ESR1
19zeranol459.9ESR1, ESR2
20mucicarmine459.9VIM, MUC1, CALB2
21trastuzumab45 51 1111.8EGFR, ESR1, MUC1, BIRC5
22mifepristone45 29 61 1112.8MUC1, ESR1, BIRC5, ESR2
23thymidylate459.8VIM, ESR2, BIRC5, EGFR
24dihydrotestosterone45 29 24 1112.7MUC1, VIM, ESR1, ESR2
25gefitinib45 51 1111.6BIRC5, ESR2, ESR1, VIM, EGFR
26actinomycin d459.5ESR1, BIRC5, ESR2, VIM, MUC1
27rapamycin459.5ANGPT1, VIM, EGFR, ESR2, BIRC5
28bicalutamide45 61 1111.3EGFR, ESR1, ESR2
29tamoxifen45 51 29 1112.3EGFR, BIRC5, VIM, ESR2, MUC1, ESR1
304-hydroxytamoxifen459.3HMGB1, ESR2, EGFR, ESR1, VIM
31b 723459.3CALB2, MUC16, VIM, MUC1
32progestin459.3ESR2, EGFR, ESR1, VIM, MUC1, ANGPT1
33hematoxylin459.3MUC1, MUC16, CALB2, VIM
34butyrate459.1HMGB1, BIRC5, CALB2, VIM, MUC1
35hyaluronic acid45 2410.1VIM, HAS1, MUC1, MUC16, CALB2
36genistein45 29 61 3 24 1114.0EGFR, ESR2, BIRC5, VIM, ESR1
37estradiol45 24 1111.0VIM, BIRC5, MUC1, MUC16, ESR2, ESR1
38retinoic acid45 249.8EGFR, ESR1, VIM, MUC1, BIRC5, HMGB1
39cisplatin45 51 61 1111.7ESR1, MUC16, MUC1, BIRC5, HMGB1, EGFR
40dexamethasone45 51 29 1111.6ESR2, MUC16, MUC1, VIM, HMGB1, BIRC5
41doxorubicin45 51 1110.6BIRC5, EGFR, MUC16, VIM, ESR1, ESR2
42paclitaxel45 51 1110.4VIM, MUC16, ANGPT1, CALB2, BIRC5, EGFR
43serine458.2HMGB1, ESR2, MUC16, MUC1, CCNE1, BIRC5
44steroid458.1CALB2, ESR2, ESR1, MUC16, ANGPT1, HMGB1
45vegf457.9BIRC5, ANGPT1, MUC1, MUC16, ESR1, EGFR
46paraffin457.9ESR1, MUC16, BIRC5, MUC1, ANGPT1, CALB2
47testosterone45 61 24 1110.7MUC1, MUC16, VIM, ESR1, ESR2, HMGB1
48calcium45 51 24 1110.2CCNE1, ANGPT1, CLDN3, CLDN15, MUC1, CALB2
49estrogen457.1HMGB1, CCNE1, ESR2, ESR1, VIM, MUC16
50progesterone45 29 61 24 1110.6CDH11, VIM, MUC16, EGFR, HMGB1, BIRC5

GO Terms for genes affiliated with Malignant Peritoneal Mesothelioma

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16Gene Ontology
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Cellular components related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.3EGFR, CDH11, ANGPT1, MUC16, VIM, ESR1

Biological processes related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:06006510.1ESR1, ESR2
2vagina developmentGO:06006810.0ESR1, ESR2
3cellular response to estradiol stimulusGO:07139210.0ESR1, EGFR
4intracellular estrogen receptor signaling pathwayGO:0305209.9ESR1, ESR2
5positive regulation of nitric oxide biosynthetic processGO:0454299.9EGFR, ESR1
6calcium-independent cell-cell adhesionGO:0163389.6CLDN15, CLDN3
7positive chemotaxisGO:0509189.3HMGB1, ANGPT1
8ossificationGO:0015039.2EGFR, CDH11, KAZALD1

Molecular functions related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.1ESR2, ESR1
2estrogen receptor activityGO:03028410.0ESR1, ESR2
3steroid bindingGO:0054969.9ESR1, ESR2
4nitric-oxide synthase regulator activityGO:0302359.9ESR1, EGFR
5core promoter sequence-specific DNA bindingGO:0010469.8ESR1, ESR2
6enzyme bindingGO:0198999.4EGFR, BIRC5, ESR1, ESR2
7identical protein bindingGO:0428028.8EGFR, BIRC5, VIM, ESR1, CLDN15, CLDN3
8protein bindingGO:0055156.8TMEM30B, ESR2, ESR1, VIM, MUC16, MUC1

Products for genes affiliated with Malignant Peritoneal Mesothelioma

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  • Antibodies
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Sources for Malignant Peritoneal Mesothelioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet