MCID: MLG002
MIFTS: 55

Malignant Peritoneal Mesothelioma malady

Cancer diseases category

Summaries for Malignant Peritoneal Mesothelioma

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MalaCards: Malignant Peritoneal Mesothelioma, also known as malignant mesothelioma of peritoneum, is related to peritonitis and malignant mesothelioma, and has symptoms including edema of the legs/lower limbs, peritoneal diseases and anomalies of the abdominal wall. An important gene associated with Malignant Peritoneal Mesothelioma is HAS1 (hyaluronan synthase 1), and among its related pathways are GPCR Pathway and Estrogen biosynthesis. The compounds estrogen and 17beta-estradiol have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and lymph node, and related mouse phenotypes are normal and tumorigenesis.

Aliases & Classifications for Malignant Peritoneal Mesothelioma

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
malignant peritoneal mesothelioma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

malignant peritoneal mesothelioma 8 10 48
malignant mesothelioma of peritoneum 8 60
advanced malignant mesothelioma of peritoneum 8
advanced peritoneal malignant mesothelioma 60
advanced malignant peritoneal mesothelioma 8
diffuse malignant peritoneal mesothelioma 48
primary malignant peritoneal mesothelioma 48
peritoneal malignant mesothelioma 8


External Ids:

Disease Ontology8 DOID:1788
NCIt39 C9350
SNOMED-CT via Orphanet57 109853004
ICD10 via Orphanet26 C45.1

Related Diseases for Malignant Peritoneal Mesothelioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malignant Peritoneal Mesothelioma family:

Benign Peritoneal Mesothelioma

Diseases related to Malignant Peritoneal Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.9MUC16
2malignant mesothelioma31.9VIM, CALB2, MUC16, MUC1
3seminoma30.4ESR2, CALB2
4li-fraumeni syndrome30.2ESR1
5papillary adenocarcinoma30.2MUC1, MUC16
6melanoma30.2VIM, CALB2, BIRC5
7cervical cancer30.2EGFR, MUC16, BIRC5
8malignant pleural mesothelioma30.2BIRC5, MUC1, MUC16, CALB2
9squamous cell carcinoma30.2VIM, CALB2, EGFR, MUC16, MUC1, CLDN3
10ovarian cancer30.2CALB2, EGFR, MUC16, MUC1, CLDN3, BIRC5
11adenocarcinoma30.2VIM, CCNE1, CALB2, EGFR, MUC16, MUC1
12ovarian malignant mesothelioma10.4
13intestinal obstruction10.3
14testis seminoma10.3
15papillary serous adenocarcinoma10.2
16sarcomatoid mesothelioma10.2
17carotid artery thrombosis10.2
18pseudomyxoma peritonei10.2
19thrombocytosis10.2
20peritoneal serous papillary adenocarcinoma10.2
21lymphangitis10.2
22thrombotic thrombocytopenic purpura10.2
23appendicitis10.2
24asbestosis10.2
25carotid artery occlusion10.2
26duodenitis10.2
27acne10.2
28cervicitis10.2
29hepatocellular carcinoma10.2
30inflammatory bowel disease10.2
31laryngeal carcinoma10.2
32laryngitis10.2
33nephrotic syndrome10.2
34peritoneal serous adenocarcinoma10.2
35purpura10.2
36leydig cell tumor10.0CALB2
37ovarian serous cystadenocarcinoma10.0MUC16
38thymoma10.0CALB2
39meigs syndrome10.0MUC16
40benign mesothelioma10.0CALB2
41pericardial effusion10.0MUC16
42sex cord-gonadal stromal tumor10.0CALB2
43gastrointestinal stromal tumor10.0VIM
44familial adenomatous polyposis10.0BIRC5
45myeloma10.0BIRC5
46benign meningioma10.0BIRC5
47fibromatosis10.0VIM
48hidradenoma10.0MUC1
49syringoma10.0MUC1
50ovarian disease10.0ESR1

Graphical network of the top 20 diseases related to Malignant Peritoneal Mesothelioma:



Diseases related to malignant peritoneal mesothelioma

Clinical Features for Malignant Peritoneal Mesothelioma

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Sources:
48Orphanet
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Symptoms:

48 (show all 10)
  • edema of the legs/lower limbs
  • peritoneal diseases
  • anomalies of the abdominal wall
  • clotting/hemostasis disorders
  • neoplasms/tumors
  • intestinal obstruction/ileus
  • acute abdominal pain/colic
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • ascitis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction

Drugs & Therapeutics for Malignant Peritoneal Mesothelioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Malignant Peritoneal Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Peritoneal Mesothelioma

Search NIH Clinical Center for Malignant Peritoneal Mesothelioma

Search CenterWatch for Malignant Peritoneal Mesothelioma

Genetic Tests for Malignant Peritoneal Mesothelioma

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Anatomical Context for Malignant Peritoneal Mesothelioma

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32MalaCards
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MalaCards organs/tissues related to Malignant Peritoneal Mesothelioma:

32
Lung, Colon, Lymph node, Testis, Liver

Animal Models for Malignant Peritoneal Mesothelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Peritoneal Mesothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5CALB2, HAS1, EGFR, MUC1, BIRC5, ESR2
2MP:00020068.4CCNE1, EGFR, MUC1, RAB25, ESR1, ESR2
3MP:00053818.3ESR2, CCNE1, EGFR, MUC1, CLDN15, RAB25

Publications for Malignant Peritoneal Mesothelioma

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50PubMed
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Articles related to Malignant Peritoneal Mesothelioma:

(show top 50)    (show all 215)
idTitleAuthorsYear
1
Anticancer property of bromelain with therapeutic potential in malignant peritoneal mesothelioma. (23570457)
2013
2
Malignant peritoneal mesothelioma presenting umbilical hernia and Sister Mary Joseph's nodule. (23951397)
2013
3
Clinical significance of serum angiopoietin-1 in malignant peritoneal mesothelioma. (24010773)
2013
4
Does the expression of BCL2 have prognostic significance in malignant peritoneal mesothelioma? (23841030)
2013
5
Huge peritoneal malignant mesothelioma mimicking primary ovarian carcinoma. (23720986)
2013
6
Quantitative X-ray computed tomography peritoneography in malignant peritoneal mesothelioma patients receiving intraperitoneal chemotherapy. (23702640)
2013
7
Diffuse malignant peritoneal mesothelioma. (24183360)
2013
8
Localized malignant peritoneal mesothelioma arising in the mesentery of the ascending colon. (22691319)
2012
9
Malignant peritoneal mesothelioma in a 16-year-old girl: presentation of a rare disease. (22513792)
2012
10
Cytoreductive surgery with selective versus complete parietal peritonectomy followed by hyperthermic intraperitoneal chemotherapy in patients with diffuse malignant peritoneal mesothelioma: a controlled study. (22302266)
2012
11
Importance of gender in diffuse malignant peritoneal mesothelioma. (22056853)
2012
12
Epidermal growth factor receptor mutations in malignant pleural and peritoneal mesothelioma. (22412050)
2012
13
Malign peritoneal mesothelioma with nephrotic syndrome. (22380502)
2012
14
18F-FDG PET/CT in a recurrent diffuse malignant peritoneal mesothelioma. (22475902)
2012
15
The need for pathological confirmation of the diagnosis of peritoneal malignant mesothelioma. (21630296)
2011
16
Activation of the phosphoinositide-3-kinase and mammalian target of rapamycin signaling pathways are associated with shortened survival in patients with malignant peritoneal mesothelioma. (20839315)
2011
17
A novel tumor-node-metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi-institutional database*. (21509762)
2011
18
Malignant peritoneal mesothelioma presenting as recurrent adhesion obstruction in general surgery: a case report. (21878098)
2011
19
Recurrent malignant peritoneal mesothelioma: radiological manifestations. (19319590)
2010
20
Colonic invasion of malignant peritoneal mesothelioma. (19913225)
2010
21
Kinetics of host cell recruitment during dissemination of diffuse malignant peritoneal mesothelioma. (21505561)
2010
22
Malignant peritoneal mesothelioma: a case report. (19943603)
2009
23
Survival of peritoneal malignant mesothelioma in Italy: a population-based study. (18792099)
2009
24
Malignant peritoneal mesothelioma: contribution and limitation of imaging for its diagnosis. (19999328)
2009
25
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience. (19917862)
2009
26
Diffuse malignant peritoneal mesothelioma in a 31-year-old patient--case report. (17479682)
2007
27
Local-regional approach to diffuse malignant peritoneal mesothelioma. (18166852)
2007
28
Spontaneous peritoneal malignant mesothelioma in a geriatric japanese macaque (Macaca fuscata). (17460361)
2007
29
Sex difference in diffuse malignant peritoneal mesothelioma. (17048277)
2006
30
Parasternal lymph node metastasis of malignant peritoneal mesothelioma: report of a case. (16133676)
2005
31
Malignant peritoneal mesothelioma. (15999348)
2005
32
Analysis of factors associated with outcome in patients with malignant peritoneal mesothelioma undergoing surgical debulking and intraperitoneal chemotherapy. (14673042)
2003
33
Aggressive multimodality treatment for primary malignant peritoneal mesothelioma. (11736836)
2001
34
Malignant peritoneal mesothelioma presenting with respiratory symptoms. (10823639)
2000
35
Malignant peritoneal mesothelioma associated with deep vein thrombosis following radiotherapy for seminoma of the testis. (11065243)
2000
36
Malignant peritoneal mesothelioma with mimicry of pseudomyxoma peritonei in a patient with a history of perforated sigmadiverticulitis. (10820864)
2000
37
A case of malignant peritoneal mesothelioma showed complete remission with chemotherapy. (9544832)
1998
38
Tc-99m MDP accumulation in primary malignant peritoneal mesothelioma. (9509941)
1998
39
Potentiation of cisplatin and carboplatin cytotoxicity by amphotericin B in different human ovarian carcinoma and malignant peritoneal mesothelioma cells. (9272114)
1997
40
Malignant peritoneal mesothelioma after Thorotrast exposure. (7542832)
1995
41
Malignant peritoneal mesothelioma mimicking mesenteric inflammatory disease. (7984521)
1994
42
Malignant peritoneal mesothelioma: a case report. (8364782)
1993
43
Asbestos body and fiber concentrations in pathological autopsy tissues of patients with malignant peritoneal mesothelioma. (8428109)
1993
44
Asbestosis, laryngeal carcinoma, and malignant peritoneal mesothelioma in an insulation worker. (2039746)
1991
45
Malignant peritoneal mesothelioma in childhood with long-term survival. (1707588)
1991
46
Malignant peritoneal mesothelioma: a series of 19 cases. (2612745)
1989
47
Malignant peritoneal mesothelioma in childhood. (2460066)
1988
48
Malignant peritoneal mesothelioma in a child. (3786268)
1986
49
Malignant peritoneal mesothelioma. (7071950)
1982
50
Malignant peritoneal mesothelioma following radiotherapy for seminoma of the testis. (476600)
1979

Genetic Variations for Malignant Peritoneal Mesothelioma

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Expression for genes affiliated with Malignant Peritoneal Mesothelioma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Peritoneal Mesothelioma

Search GEO for disease gene expression data for Malignant Peritoneal Mesothelioma.

Pathways for genes affiliated with Malignant Peritoneal Mesothelioma

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Sources:
51QIAGEN, 53Reactome, 49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Malignant Peritoneal Mesothelioma

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4CALB2
217beta-estradiol2810.3ESR1, ESR2
34-hydroxy? tamoxifen2810.3ESR1, ESR2
4methylparaben4410.2ESR1, ESR2
5r,r-thc2810.2ESR2, ESR1
6(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR2, ESR1
7(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR2, ESR1
8(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR2, ESR1
94-octylphenol4410.2ESR1, ESR2
10isopropylparaben4410.2ESR2, ESR1
1117alpha estradiol4410.2ESR2, ESR1
122,4,6-trichloro-4-biphenylol4410.2ESR2, ESR1
13isobutylparaben4410.2ESR2, ESR1
14ly 1170184410.2ESR2, ESR1
15lasofoxifene4410.1ESR2, ESR1
16butylparaben4410.1ESR2, ESR1
17lapatinib44 49 1112.1ESR1, BIRC5, EGFR
18daidzein4410.0ESR2, ESR1, BIRC5
19[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE1110.0ESR1, ESR2
20taxane4410.0EGFR, BIRC5, ESR1
21exemestane49 44 59 1113.0EGFR, ESR1, ESR2
22fulvestrant44 49 28 1113.0EGFR, ESR1, ESR2
234-tert-octylphenol4410.0ESR1, ESR2
24letrozole44 49 59 1113.0EGFR, ESR1, ESR2
25zeranol4410.0ESR1, ESR2
26ppt59 2810.9ESR2, ESR1
27mucicarmine449.9MUC1, CALB2, VIM
28thymidylate449.8VIM, EGFR, BIRC5, ESR2
29trastuzumab44 49 1111.8EGFR, MUC1, BIRC5, ESR1
304-hydroxytamoxifen449.8VIM, EGFR, ESR1, ESR2
31bicalutamide44 59 1111.8ESR2, ESR1, EGFR
32(z)-4-hydroxytamoxifen599.8ESR2, ESR1
33mifepristone44 59 28 1112.8MUC1, BIRC5, ESR1, ESR2
34dihydrotestosterone44 28 11 2412.6VIM, MUC1, ESR1, ESR2
35gefitinib44 49 1111.6VIM, EGFR, BIRC5, ESR1, ESR2
36ici 182,780599.6ESR2, ESR1
37progestin449.6VIM, EGFR, MUC1, ESR1, ESR2
38actinomycin d449.4VIM, MUC1, BIRC5, ESR1, ESR2
39tamoxifen44 49 28 1112.3VIM, EGFR, MUC1, BIRC5, ESR1, ESR2
40b 723449.3VIM, CALB2, MUC16, MUC1
41hematoxylin449.3MUC1, MUC16, CALB2, VIM
42genistein44 28 59 2 11 2414.2VIM, EGFR, BIRC5, ESR1, ESR2
43hyaluronic acid44 2410.1VIM, CALB2, HAS1, MUC16, MUC1
44estradiol44 11 2411.0VIM, MUC16, MUC1, BIRC5, ESR1, ESR2
45doxorubicin44 49 1111.0VIM, EGFR, MUC16, BIRC5, ESR1, ESR2
46paclitaxel44 49 1111.0CALB2, EGFR, MUC16, BIRC5, ESR1
47vegf448.4VIM, EGFR, MUC16, MUC1, CLDN3, BIRC5
48paraffin448.2VIM, CALB2, EGFR, MUC16, MUC1, BIRC5
49testosterone44 59 11 2411.2VIM, CALB2, EGFR, MUC16, MUC1, BIRC5
50progesterone44 59 28 11 2411.2ESR2, VIM, CCNE1, CALB2, EGFR, MUC16

GO Terms for genes affiliated with Malignant Peritoneal Mesothelioma

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16Gene Ontology
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Biological processes related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to estradiol stimulusGO:0713929.9ESR1, EGFR
2uterus developmentGO:0600659.9ESR2, ESR1
3vagina developmentGO:0600689.8ESR1, ESR2
4intracellular estrogen receptor signaling pathwayGO:0305209.6ESR2, ESR1
5ossificationGO:0015039.1CDH11, EGFR, KAZALD1

Molecular functions related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.0ESR1, ESR2
2estrogen receptor activityGO:03028410.0ESR2, ESR1
3nitric-oxide synthase regulator activityGO:0302359.9ESR1, EGFR
4core promoter sequence-specific DNA bindingGO:0010469.6ESR2, ESR1
5enzyme bindingGO:0198999.3EGFR, BIRC5, ESR1, ESR2
6identical protein bindingGO:0428028.9ESR1, BIRC5, CLDN15, CLDN3, EGFR, VIM
7protein bindingGO:0055156.7CCNE1, CCAR1, EGFR, MUC16, MUC1, BIRC5

Products for genes affiliated with Malignant Peritoneal Mesothelioma

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  • Antibodies
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Sources for Malignant Peritoneal Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet