MCID: MLG002
MIFTS: 55

Malignant Peritoneal Mesothelioma malady

Cancer diseases category

Summaries for Malignant Peritoneal Mesothelioma

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MalaCards: Malignant Peritoneal Mesothelioma, also known as malignant mesothelioma of peritoneum, is related to peritonitis and malignant mesothelioma, and has symptoms including clotting/hemostasis disorders, edema of the legs/lower limbs and respiratory distress/dyspnea/respiratory failure/lung volume reduction. An important gene associated with Malignant Peritoneal Mesothelioma is HAS1 (hyaluronan synthase 1), and among its related pathways are GPCR Pathway and Estrogen biosynthesis. The compounds estrogen and butylparaben have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and lymph node, and related mouse phenotypes are normal and tumorigenesis.

Aliases & Classifications for Malignant Peritoneal Mesothelioma

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Characteristics (Orphanet epidemiological data):

48
malignant peritoneal mesothelioma:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

malignant peritoneal mesothelioma 8 10 48
malignant mesothelioma of peritoneum 8 60
advanced malignant mesothelioma of peritoneum 8
advanced peritoneal malignant mesothelioma 60
advanced malignant peritoneal mesothelioma 8
diffuse malignant peritoneal mesothelioma 48
primary malignant peritoneal mesothelioma 48
peritoneal malignant mesothelioma 8


External Ids:

Disease Ontology8 DOID:1788
NCIt39 C9350
SNOMED-CT via Orphanet57 109853004
ICD10 via Orphanet26 C45.1

Related Diseases for Malignant Peritoneal Mesothelioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malignant Peritoneal Mesothelioma family:

Benign Peritoneal Mesothelioma

Diseases related to Malignant Peritoneal Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 128)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.9MUC16
2malignant mesothelioma31.9VIM, CALB2, MUC16, MUC1
3seminoma30.4ESR2, CALB2
4li-fraumeni syndrome30.2ESR1
5papillary adenocarcinoma30.2MUC1, MUC16
6melanoma30.2VIM, CALB2, BIRC5
7cervical cancer30.2EGFR, MUC16, BIRC5
8malignant pleural mesothelioma30.2BIRC5, MUC1, MUC16, CALB2
9squamous cell carcinoma30.2VIM, CALB2, EGFR, MUC16, MUC1, CLDN3
10ovarian cancer30.2CALB2, EGFR, MUC16, MUC1, CLDN3, BIRC5
11adenocarcinoma30.2VIM, CCNE1, CALB2, EGFR, MUC16, MUC1
12ovarian malignant mesothelioma10.4
13intestinal obstruction10.3
14testis seminoma10.3
15papillary serous adenocarcinoma10.2
16sarcomatoid mesothelioma10.2
17carotid artery thrombosis10.2
18pseudomyxoma peritonei10.2
19thrombocytosis10.2
20peritoneal serous papillary adenocarcinoma10.2
21lymphangitis10.2
22thrombotic thrombocytopenic purpura10.2
23appendicitis10.2
24asbestosis10.2
25carotid artery occlusion10.2
26duodenitis10.2
27acne10.2
28cervicitis10.2
29hepatocellular carcinoma10.2
30inflammatory bowel disease10.2
31laryngeal carcinoma10.2
32laryngitis10.2
33nephrotic syndrome10.2
34peritoneal serous adenocarcinoma10.2
35purpura10.2
36leydig cell tumor10.0CALB2
37ovarian serous cystadenocarcinoma10.0MUC16
38thymoma10.0CALB2
39meigs syndrome10.0MUC16
40benign mesothelioma10.0CALB2
41pericardial effusion10.0MUC16
42sex cord-gonadal stromal tumor10.0CALB2
43gastrointestinal stromal tumor10.0VIM
44familial adenomatous polyposis10.0BIRC5
45myeloma10.0BIRC5
46benign meningioma10.0BIRC5
47fibromatosis10.0VIM
48hidradenoma10.0MUC1
49syringoma10.0MUC1
50ovarian disease10.0ESR1

Graphical network of the top 20 diseases related to Malignant Peritoneal Mesothelioma:



Diseases related to malignant peritoneal mesothelioma

Clinical Features for Malignant Peritoneal Mesothelioma

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Sources:
48Orphanet
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Symptoms:

48 (show all 10)
  • clotting/hemostasis disorders
  • edema of the legs/lower limbs
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • intestinal obstruction/ileus
  • weight loss/loss of appetite/break in weight curve/general health alteration
  • neoplasms/tumors
  • peritoneal diseases
  • acute abdominal pain/colic
  • ascitis
  • anomalies of the abdominal wall

Drugs & Therapeutics for Malignant Peritoneal Mesothelioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Malignant Peritoneal Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Peritoneal Mesothelioma

Search NIH Clinical Center for Malignant Peritoneal Mesothelioma

Search CenterWatch for Malignant Peritoneal Mesothelioma

Genetic Tests for Malignant Peritoneal Mesothelioma

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Anatomical Context for Malignant Peritoneal Mesothelioma

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32MalaCards
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MalaCards organs/tissues related to Malignant Peritoneal Mesothelioma:

32
Lung, Colon, Lymph node, Testis, Liver

Animal Models for Malignant Peritoneal Mesothelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Peritoneal Mesothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.5CALB2, HAS1, EGFR, MUC1, BIRC5, ESR2
2MP:00020068.4CCNE1, EGFR, MUC1, RAB25, ESR1, ESR2
3MP:00053818.3ESR2, CCNE1, EGFR, MUC1, CLDN15, RAB25

Publications for Malignant Peritoneal Mesothelioma

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Sources:
50PubMed
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Articles related to Malignant Peritoneal Mesothelioma:

(show top 50)    (show all 215)
idTitleAuthorsYear
1
Malignant peritoneal mesothelioma (MPM) who responded to rechallenge with cisplatin and pemetrexed with current literature review. (23291819)
2013
2
Malignant Peritoneal Mesothelioma: Prognostic Factors and Oncologic Outcome Analysis. (24322529)
2013
3
The role of perioperative systemic chemotherapy in diffuse malignant peritoneal mesothelioma patients treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. (23456386)
2013
4
MUC1 has prognostic significance in malignant peritoneal mesothelioma. (23828409)
2013
5
Localized malignant peritoneal mesothelioma arising in the mesentery of the ascending colon. (22546096)
2012
6
Multipotent cancer stem cells derived from human malignant peritoneal mesothelioma promote tumorigenesis. (23285196)
2012
7
Diffuse malignant peritoneal mesothelioma--an update on treatment. (22104079)
2012
8
The diagnostic and molecular characteristics of malignant mesothelioma and ovarian/peritoneal serous carcinoma. (21114695)
2011
9
In vivo imaging of human malignant mesothelioma grown orthotopically in the peritoneal cavity of nude mice. (21479131)
2011
10
Systemic chemotherapy with pemetrexed and cisplatin for malignant peritoneal mesothelioma: a single institution experience. (21528659)
2011
11
Surgical treatment of malignant peritoneal mesothelioma: past, present, and future. (19888634)
2010
12
The efficacy of the frontline platinum-based combination chemotherapy in malignant peritoneal mesothelioma. (20534685)
2010
13
Malignant peritoneal mesothelioma: a multicenter study on 81 cases. (19635740)
2010
14
Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma. (20692828)
2010
15
Two-stage operative cytoreduction and intraperitoneal chemotherapy for diffuse malignant peritoneal mesothelioma: Operative morbidity and mortality in phase I and II trials. (20674253)
2010
16
Combination chemotherapy with cisplatin and gemcitabine in malignant peritoneal mesothelioma. (19593622)
2009
17
Malignant peritoneal mesothelioma. (21160794)
2009
18
Malignant peritoneal mesothelioma-Results from the International Expanded Access Program using pemetrexed alone or in combination with a platinum agent. (19042053)
2009
19
Combined resection, intraperitoneal chemotherapy, and whole abdominal radiation for the treatment of malignant peritoneal mesothelioma. (18376228)
2008
20
Morbidity and mortality assessment of cytoreductive surgery and perioperative intraperitoneal chemotherapy for diffuse malignant peritoneal mesothelioma--a prospective study of 70 consecutive cases. (17031722)
2007
21
Clinical results of cytoreduction and HIPEC for malignant peritoneal mesothelioma. (17633065)
2007
22
Molecular profiling of malignant peritoneal mesothelioma identifies the ubiquitin-proteasome pathway as a therapeutic target in poor prognosis tumors. (16862182)
2007
23
Education and imaging. Gastrointestinal: malignant peritoneal mesothelioma. (16911701)
2006
24
Dramatic tumour response to pemetrexed single-agent in an elderly patient with malignant peritoneal mesothelioma: a case report. (17176466)
2006
25
Incidental finding of a malignant peritoneal mesothelioma in an inguinal hernia sac: report of a case. (17139996)
2006
26
Comprehensive management of diffuse malignant peritoneal mesothelioma. (16621431)
2006
27
Abdominal computed tomography scans in the selection of patients with malignant peritoneal mesothelioma for comprehensive treatment with cytoreductive surgery and perioperative intraperitoneal chemotherapy. (15637690)
2005
28
Malignant peritoneal mesothelioma in women: a study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis. (15981812)
2005
29
Sister Mary Joseph's nodule in malignant peritoneal mesothelioma. (12940787)
2003
30
Best cases from the AFIP. Malignant peritoneal mesothelioma. (12432120)
2002
31
Primary malignant peritoneal mesothelioma: appearance on F-18 FDG positron emission tomographic images. (12607890)
2002
32
Malignant peritoneal mesothelioma. (12057102)
2001
33
Prospective trial for the treatment of malignant peritoneal mesothelioma. (11603562)
2001
34
Malignant peritoneal mesothelioma in an inguinal hernial sac: an unusual presentation. (11876616)
2000
35
Malignant peritoneal mesothelioma: mucosal duodenal involvement and endoscopic diagnosis. (10922109)
2000
36
Clinical picture, response to therapy, and survival of women with diffuse malignant peritoneal mesothelioma. (9989414)
1999
37
Malignant peritoneal mesothelioma. (10547260)
1998
38
Malignant peritoneal mesothelioma. Case-report demonstrating pitfalls of diagnostic laparoscopy. (9372366)
1997
39
Malignant mesothelioma: immunohistochemistry and DNA ploidy analysis as methods to differentiate mesothelioma from benign reactive mesothelial cell proliferation and adenocarcinoma in pleural and peritoneal effusions. (12046609)
1996
40
Cystic appearance of a malignant peritoneal mesothelioma by ultrasonography and computed tomography: a case report. (8055987)
1994
41
Malignant peritoneal mesothelioma with squamous metaplasia. (8110978)
1993
42
Diffuse malignant peritoneal mesothelioma in a young woman with a high serum level of CA125. (1710413)
1991
43
Autoimmune haemolytic anaemia associated with malignant peritoneal mesothelioma. (2816228)
1989
44
CT findings of hypervascular malignant peritoneal mesothelioma. (3608453)
1987
45
Malignant peritoneal mesothelioma: advances in diagnosis and management. (3949556)
1986
46
Malignant peritoneal mesothelioma: a difficult diagnosis. (3710751)
1986
47
Occurrence of malignant peritoneal mesothelioma after surgery and irradiation for cervical cancer. (6706236)
1984
48
Malignant peritoneal mesothelioma: review of 25 patients. (7258177)
1981
49
Malignant peritoneal mesothelioma. (903634)
1977
50
Malignant peritoneal mesothelioma in an inguinal hernia sac. (1260691)
1976

Genetic Variations for Malignant Peritoneal Mesothelioma

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Expression for genes affiliated with Malignant Peritoneal Mesothelioma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Peritoneal Mesothelioma

Search GEO for disease gene expression data for Malignant Peritoneal Mesothelioma.

Pathways for genes affiliated with Malignant Peritoneal Mesothelioma

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Sources:
51QIAGEN, 53Reactome, 49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database
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Compounds for genes affiliated with Malignant Peritoneal Mesothelioma

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1estrogen4410.4CALB2
2butylparaben4410.3ESR1, ESR2
34-octylphenol4410.3ESR2, ESR1
4(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-6-(METHOXYMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR2, ESR1
5methylparaben4410.2ESR2, ESR1
62,4,6-trichloro-4-biphenylol4410.2ESR2, ESR1
74-hydroxy? tamoxifen2810.2ESR2, ESR1
817beta-estradiol2810.2ESR2, ESR1
9(3AS,4R,9BR)-2,2-DIFLUORO-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR1, ESR2
10(3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL1110.2ESR1, ESR2
11r,r-thc2810.2ESR1, ESR2
12lasofoxifene4410.2ESR1, ESR2
13ly 1170184410.2ESR1, ESR2
1417alpha estradiol4410.2ESR1, ESR2
15isopropylparaben4410.1ESR2, ESR1
16isobutylparaben4410.1ESR2, ESR1
17lapatinib44 49 1112.1BIRC5, ESR1, EGFR
18daidzein4410.0ESR1, ESR2, BIRC5
194-tert-octylphenol4410.0ESR2, ESR1
20taxane4410.0EGFR, BIRC5, ESR1
21exemestane49 44 59 1113.0EGFR, ESR2, ESR1
22fulvestrant44 49 28 1113.0EGFR, ESR2, ESR1
23zeranol4410.0ESR2, ESR1
24letrozole44 49 59 1113.0EGFR, ESR2, ESR1
25[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE1110.0ESR2, ESR1
26(z)-4-hydroxytamoxifen599.9ESR1, ESR2
27mucicarmine449.9MUC1, VIM, CALB2
28thymidylate449.8VIM, BIRC5, ESR2, EGFR
29trastuzumab44 49 1111.8MUC1, BIRC5, EGFR, ESR1
304-hydroxytamoxifen449.8ESR2, EGFR, ESR1, VIM
31bicalutamide44 59 1111.8EGFR, ESR1, ESR2
32coumestrol44 210.8ESR2, ESR1
33mifepristone44 59 28 1112.8ESR2, MUC1, BIRC5, ESR1
34dihydrotestosterone44 28 11 2412.6MUC1, ESR2, ESR1, VIM
35gefitinib44 49 1111.6ESR1, BIRC5, EGFR, VIM, ESR2
36ici 182,780599.6ESR1, ESR2
37progestin449.6EGFR, ESR1, MUC1, ESR2, VIM
38actinomycin d449.4MUC1, ESR2, ESR1, VIM, BIRC5
39tamoxifen44 49 28 1112.3BIRC5, VIM, ESR1, ESR2, EGFR, MUC1
40b 723449.3MUC1, MUC16, CALB2, VIM
41hematoxylin449.3VIM, MUC16, CALB2, MUC1
42genistein44 28 59 2 11 2414.2ESR2, ESR1, BIRC5, VIM, EGFR
43hyaluronic acid44 2410.1MUC1, CALB2, HAS1, VIM, MUC16
44estradiol44 11 2411.0BIRC5, MUC16, MUC1, ESR1, ESR2, VIM
45doxorubicin44 49 1111.0MUC16, VIM, EGFR, BIRC5, ESR1, ESR2
46paclitaxel44 49 1111.0ESR1, BIRC5, MUC16, EGFR, CALB2
47vegf448.4VIM, EGFR, MUC16, MUC1, CLDN3, ESR2
48paraffin448.2MUC16, VIM, CALB2, EGFR, MUC1, BIRC5
49testosterone44 59 11 2411.2ESR2, ESR1, BIRC5, MUC1, VIM, EGFR
50progesterone44 59 28 11 2411.2CDH11, VIM, CCNE1, ESR2, ESR1, BIRC5

GO Terms for genes affiliated with Malignant Peritoneal Mesothelioma

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16Gene Ontology
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Biological processes related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to estradiol stimulusGO:0713929.9ESR1, EGFR
2uterus developmentGO:0600659.9ESR2, ESR1
3vagina developmentGO:0600689.8ESR1, ESR2
4intracellular estrogen receptor signaling pathwayGO:0305209.6ESR2, ESR1
5ossificationGO:0015039.1CDH11, EGFR, KAZALD1

Molecular functions related to Malignant Peritoneal Mesothelioma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1estrogen response element bindingGO:03405610.0ESR1, ESR2
2estrogen receptor activityGO:03028410.0ESR2, ESR1
3nitric-oxide synthase regulator activityGO:0302359.9ESR1, EGFR
4core promoter sequence-specific DNA bindingGO:0010469.6ESR2, ESR1
5enzyme bindingGO:0198999.3EGFR, BIRC5, ESR1, ESR2
6identical protein bindingGO:0428028.9ESR1, BIRC5, CLDN15, CLDN3, EGFR, VIM
7protein bindingGO:0055156.7CCNE1, CCAR1, EGFR, MUC16, MUC1, BIRC5

Products for genes affiliated with Malignant Peritoneal Mesothelioma

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  • Antibodies
  • Proteins
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Sources for Malignant Peritoneal Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet