MCID: MLG079
MIFTS: 48

Malignant Pleural Mesothelioma malady

Cancer diseases category

Summaries for Malignant Pleural Mesothelioma

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32MalaCards
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MalaCards: Malignant Pleural Mesothelioma, also known as malignant mesothelioma of the pleura, is related to malignant mesothelioma and lung cancer. An important gene associated with Malignant Pleural Mesothelioma is GSTT2 (glutathione S-transferase theta 2), and among its related pathways are Biological oxidations and Drug metabolism - cytochrome P450. The compounds noradrenochrome and hydrochloric acid have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and testes, and related mouse phenotype normal.

Aliases & Classifications for Malignant Pleural Mesothelioma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant pleural mesothelioma 8 10 60
malignant mesothelioma of the pleura 8
malignant mesothelioma of pleura 8
pleural malignant mesothelioma 44
mesothelioma of pleura 8


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Disease Ontology8 DOID:7474
NCIt39 C7376
ICD1025 C45.0

Related Diseases for Malignant Pleural Mesothelioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malignant Pleural Mesothelioma family:

Benign Pleural Mesothelioma

Diseases related to Malignant Pleural Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mesothelioma32.3CALB2, CT49, CD7, MSLN
2lung cancer30.9CT49, BIRC7, MSLN, CEACAM7, TPBG, GSTM3
3adenocarcinoma30.8CALB2, CT49, MSLN, CEACAM7, TPBG
4squamous cell carcinoma30.5CALB2, CT49, MSLN, CEACAM7, TPBG, GSTM3
5benign mesothelioma30.5CALB2, CT49, MSLN, CEACAM7
6cervical cancer30.2CEACAM7
7asbestosis30.2MSLN
8pleural cancer10.8
9malignant epithelial mesothelioma10.6
10sarcomatoid mesothelioma10.6
11benign pleural mesothelioma10.3
12cervicitis10.3
13esophageal cancer10.3
14esophagitis10.3
15mediastinitis10.3
16pneumothorax10.3
17lymphohistiocytoid mesothelioma10.3
18burns10.2
19membranous glomerulonephritis10.2
20newcastle disease10.2
21vaccinia10.2
22malignant biphasic mesothelioma10.2
23ataxia telangiectasia10.2
24megakaryocytic tumor10.2
25intussusception10.2
26clear cell sarcoma10.2
27malignant hyperthermia10.2
28duodenitis10.2
29hypercalcemia10.2
30angiosarcoma10.2
31diffuse glomerulonephritis10.2
32endometriosis10.2
33glomerulonephritis10.2
34lung adenocarcinoma10.2
35lung squamous cell carcinoma10.2
36pleural empyema10.2
37renal cell carcinoma10.2
38sarcoma10.2
39stomatitis10.2
40thoracic cancer10.2
41vasculitis10.2
42benign fibrous mesothelioma10.2
43colorectal cancer10.0CT49, LPAR2, BIRC7, CEACAM7, TPBG, GSTA2
44breast cancer10.0LPAR2, MSLN, CEACAM7, TPBG, GSTA2, GSTM3
45adenoma10.0CALB2, CT49, CEACAM7, GSTA2, GSTA4
46melanoma10.0CALB2, IRF9, CT49, BIRC7, CEACAM7, TPBG
47colon cancer10.0CALB2, CT49, LPAR2, CEACAM7
48leukemia10.0GSTA4, GSTA2, CD7, PPP1R15A
49stomach cancer10.0LPAR2, CEACAM7, TPBG
50hepatocellular carcinoma10.0CT49, CEACAM7, GSTA2, GSTA4

Graphical network of the top 20 diseases related to Malignant Pleural Mesothelioma:



Diseases related to malignant pleural mesothelioma

Clinical Features for Malignant Pleural Mesothelioma

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Drugs & Therapeutics for Malignant Pleural Mesothelioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Malignant Pleural Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Pleural Mesothelioma

Search NIH Clinical Center for Malignant Pleural Mesothelioma

Search CenterWatch for Malignant Pleural Mesothelioma

Genetic Tests for Malignant Pleural Mesothelioma

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Anatomical Context for Malignant Pleural Mesothelioma

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32MalaCards
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MalaCards organs/tissues related to Malignant Pleural Mesothelioma:

32
Lung, Endothelial, Testes, T cells, Lymph node, Brain, Bone, Spinal cord, Tongue, Breast, Skin, Placenta

Animal Models for Malignant Pleural Mesothelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Pleural Mesothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.8GSTT2, MSLN, GDF10, ITLN1, LPAR2, PPP1R15A

Publications for Malignant Pleural Mesothelioma

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50PubMed
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Articles related to Malignant Pleural Mesothelioma:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
Surgery in the treatment of malignant pleural mesothelioma: recruitment into trials should be the default position. (23760546)
2014
2
Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma. (24434429)
2014
3
Antitumor effect and antiangiogenic potential of the mTOR inhibitor temsirolimus against malignant pleural mesothelioma. (24378576)
2013
4
Hyperthermic intraoperative pleural cisplatin chemotherapy extends interval to recurrence and survival among low-risk patients with malignant pleural mesothelioma undergoing surgical macroscopic complete resection. (23434448)
2013
5
Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma. (23975423)
2013
6
Circulating Tumor Cells (CTCs) in Malignant Pleural Mesothelioma (MPM). (24306661)
2013
7
Negative modulation of mitochondrial oxidative phosphorylation by epigallocatechin-3 gallate leads to growth arrest and apoptosis in human malignant pleural mesothelioma cells. (23911347)
2013
8
Extra-pleural pneumonectomy in the setting of tri-modality therapy for patients with malignant pleural mesothelioma. (23592890)
2013
9
Mutation analysis of the EGFR gene and downstream signalling pathway in histologic samples of malignant pleural mesothelioma. (23558893)
2013
10
Identification of a seven glycopeptide signature for malignant pleural mesothelioma in human serum by selected reaction monitoring. (24207061)
2013
11
Systematic review of pleurectomy in the treatment of malignant pleural mesothelioma. (23769317)
2013
12
A phase II clinical trial of the vascular disrupting agent BNC105P as second line chemotherapy for advanced Malignant Pleural Mesothelioma. (23787063)
2013
13
Simultaneous bilateral spontaneous hydropneumothorax: a rare presentation of bilateral malignant pleural mesothelioma. (23682089)
2013
14
Guidelines for the diagnosis and treatment of malignant pleural mesothelioma. (24416529)
2013
15
Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma. (23428976)
2013
16
Data-driven information retrieval in heterogeneous collections of transcriptomics data links SIM2s to malignant pleural mesothelioma. (22106335)
2012
17
Pleurectomy/decortication is superior to extrapleural pneumonectomy in the multimodality management of patients with malignant pleural mesothelioma. (22425923)
2012
18
Re-directed T cells for the treatment of fibroblast activation protein (FAP)-positive malignant pleural mesothelioma (FAPME-1). (23259649)
2012
19
A comparison of epidermal growth factor receptor expression in malignant peritoneal and pleural mesothelioma. (22449226)
2012
20
Malignant pleural mesothelioma. (22345416)
2012
21
Incidence and survival of malignant pleural mesothelioma in norway: a population-based study of 1686 cases. (23154557)
2012
22
An electronic nose distinguishes exhaled breath of patients with Malignant Pleural Mesothelioma from controls. (21924516)
2012
23
Circulating tumor cells as a diagnostic test for malignant pleural mesothelioma. (23480683)
2012
24
Paraneoplastic leukocytoclastic vasculitis as an initial presentation of malignant pleural mesothelioma: a case report. (22937937)
2012
25
Circulating endothelial cell (CEC) as a diagnostic and prognostic marker in malignant pleural mesothelioma (MPM). (22825770)
2012
26
Bilateral dissemination of malignant pleural mesothelioma via iatrogenic buffalo chest: a rare route of disease progression. (22580971)
2012
27
Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy. (21310625)
2011
28
Lack of evidence in malignant pleural mesothelioma surgery. (21345821)
2011
29
Advances in the biology of malignant pleural mesothelioma. (21288646)
2011
30
Recommendations for uniform definitions of surgical techniques for malignant pleural mesothelioma: a consensus report of the international association for the study of lung cancer international staging committee and the international mesothelioma interest group. (21847060)
2011
31
Pleural effusion VEGF levels as a prognostic factor of malignant pleural mesothelioma. (21041073)
2011
32
Detection of integrin-linked kinase in the serum of patients with malignant pleural mesothelioma. (21620418)
2011
33
Volumetry: an alternative to assess therapy response for malignant pleural mesothelioma? (21273389)
2011
34
Premature senescence induced by DNA demethylating agent (Decitabine) as therapeutic option for malignant pleural mesothelioma. (21095037)
2011
35
Extra-pleural pneumonectomy versus no extra-pleural pneumonectomy for patients with malignant pleural mesothelioma: clinical outcomes of the Mesothelioma and Radical Surgery (MARS) randomised feasibility study. (21723781)
2011
36
A practical guide of the Southwest Oncology Group to measure malignant pleural mesothelioma tumors by RECIST and modified RECIST criteria. (21270668)
2011
37
Phase II study of cediranib in patients with malignant pleural mesothelioma: SWOG S0509. (21964533)
2011
38
Re-evaluating the role of palliative radiotherapy in malignant pleural mesothelioma. (21658936)
2011
39
A rare cause of dysphagia: malignant pleural mesothelioma in the posterior mediastinum. (20868849)
2010
40
Cytokeratin 19 fragment/carcinoembryonic antigen ratio in pleural effusion is a useful marker for detecting malignant pleural mesothelioma. (21036761)
2010
41
Role of integrated 18-fluorodeoxyglucose position emission tomography-computed tomography in patients surveillance after multimodality therapy of malignant pleural mesothelioma. (20087231)
2010
42
Carboplatin plus pemetrexed as first-line treatment of patients with malignant pleural mesothelioma: a phase II study. (20085865)
2010
43
Malignant pleural mesothelioma: genome-wide expression patterns reflecting general resistance mechanisms and a proposal of novel targets. (19380173)
2010
44
Maxillary sinus carcinoma metastases mimicking malignant pleural mesothelioma. (21683005)
2010
45
Surgical assessment of malignant pleural mesothelioma: have we reached a critical stage? (20138534)
2010
46
Kinetics of soluble mesothelin in patients with malignant pleural mesothelioma during treatment. (19201924)
2009
47
Differentially expressed alternatively spliced genes in malignant pleural mesothelioma identified using massively parallel transcriptome sequencing. (20043850)
2009
48
Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma. (16516163)
2006
49
Identification of intelectin overexpression in malignant pleural mesothelioma by serial analysis of gene expression (SAGE). (15777968)
2005
50
Thrombomodulin expression in malignant pleural mesothelioma and pulmonary adenocarcinoma. (1357974)
1992

Genetic Variations for Malignant Pleural Mesothelioma

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Expression for genes affiliated with Malignant Pleural Mesothelioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Pleural Mesothelioma

Search GEO for disease gene expression data for Malignant Pleural Mesothelioma.

Pathways for genes affiliated with Malignant Pleural Mesothelioma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7GSTA4, GSTM3, GSTT2, GSTA2
2
Hide members
10.7GSTA2, GSTT2, GSTM3, GSTA4
3
Glutathione metabolism
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10.7GSTA4, GSTM3, GSTT2, GSTA2

Compounds for genes affiliated with Malignant Pleural Mesothelioma

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44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1noradrenochrome44 2411.9GSTA4, GSTM3, GSTT2, GSTA2
2hydrochloric acid44 2411.9GSTA2, GSTT2, GSTM3, GSTA4
3adrenochrome44 2411.8GSTA4, GSTM3, GSTT2, GSTA2
4gsts4410.8GSTA2, GSTT2, GSTM3, GSTA4
5Glutathione11 2411.7GSTA4, GSTM3, GSTT2, GSTA2
6sulfate44 2411.7GSTA2, GSTT2, GSTM3, GSTA4
7Vitamin E1110.6GSTM3, GSTA2
8b 7234410.5CEACAM7, MSLN, CALB2
9mucicarmine4410.3CEACAM7, CALB2

GO Terms for genes affiliated with Malignant Pleural Mesothelioma

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16Gene Ontology
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Cellular components related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.6CEACAM7, MSLN, ITLN1

Biological processes related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680510.6GSTA4, GSTM3, GSTA2
2glutathione derivative biosynthetic processGO:190168710.5GSTA4, GSTM3, GSTA2
3glutathione metabolic processGO:00674910.3GSTA4, GSTM3, GSTA2

Molecular functions related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00436410.7GSTA4, GSTM3, GSTT2, GSTA2

Products for genes affiliated with Malignant Pleural Mesothelioma

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  • Antibodies
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Sources for Malignant Pleural Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet