MCID: MLG079
MIFTS: 41

Malignant Pleural Mesothelioma malady

Cancer category

Summaries for Malignant Pleural Mesothelioma

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33MalaCards
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MalaCards: Malignant Pleural Mesothelioma, also known as malignant mesothelioma of the pleura, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Malignant Pleural Mesothelioma is GSTT2 (glutathione S-transferase theta 2), and among its related pathways are Biological oxidations and Drug metabolism - cytochrome P450. The compounds noradrenochrome and hydrochloric acid have been mentioned in the context of this disorder. Related mouse phenotype normal.

Aliases & Classifications for Malignant Pleural Mesothelioma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

malignant pleural mesothelioma 8 10 61
malignant mesothelioma of the pleura 8
malignant mesothelioma of pleura 8
pleural malignant mesothelioma 45
mesothelioma of pleura 8


External Ids:

Disease Ontology8 DOID:7474
NCIt40 C7376
ICD1025 C45.0

Related Diseases for Malignant Pleural Mesothelioma

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malignant Pleural Mesothelioma family:

benign pleural mesothelioma

Diseases related to Malignant Pleural Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.8CALB2, CT49, MSLN, CEACAM7, TPBG
2squamous cell carcinoma30.5CALB2, CT49, MSLN, CEACAM7, TPBG, GSTM3
3benign mesothelioma30.5CALB2, CT49, MSLN, CEACAM7
4asbestosis30.3MSLN
5malignant epithelial mesothelioma10.6
6sarcomatoid mesothelioma10.6
7benign pleural mesothelioma10.4
8spontaneous pneumothorax10.4
9lymphohistiocytoid mesothelioma10.3
10membranous glomerulonephritis10.2
11newcastle disease10.2
12vaccinia10.2
13malignant biphasic mesothelioma10.2
14ataxia telangiectasia10.2
15cushing's syndrome10.2
16colon squamous cell carcinoma10.2
17intussusception10.2
18clear cell sarcoma10.2
19malignant hyperthermia10.2
20hypercalcemia10.2
21angiosarcoma10.2
22bone osteosarcoma10.2
23stomatitis10.2
24thoracic cancer10.2
25vasculitis10.2
26wilms tumor10.2
27cerebellar degeneration10.2
28paraneoplastic cerebellar degeneration10.2
29ataxia10.2
30back pain10.2
31dysphagia10.2
32hypoxia10.2
33mesothelioma, somatic10.2
34pulmonary function10.2
35benign fibrous mesothelioma10.2
36solitary fibrous tumor10.2
37colorectal cancer10.0CT49, LPAR2, BIRC7, CEACAM7, TPBG, GSTA2
38breast cancer10.0LPAR2, MSLN, CEACAM7, TPBG, GSTA2, GSTM3
39adenoma10.0CALB2, CT49, CEACAM7, GSTA2, GSTA4
40malignant mesothelioma10.0CALB2, CT49, CD7, MSLN
41lung cancer10.0CT49, BIRC7, MSLN, CEACAM7, TPBG, GSTM3
42melanoma10.0CALB2, IRF9, CT49, BIRC7, CEACAM7, TPBG
43colon cancer10.0CALB2, CT49, LPAR2, CEACAM7
44leukemia10.0GSTA4, GSTA2, CD7, PPP1R15A
45stomach cancer10.0LPAR2, CEACAM7, TPBG
46cervical cancer10.0CEACAM7
47hepatocellular carcinoma10.0CT49, CEACAM7, GSTA2, GSTA4
48prostate cancer10.0GSTA4, GSTA2, CT49
49astrocytoma10.0CT49, GSTM3
50kidney cancer10.0CALB2, BIRC7, MSLN, TPBG

Graphical network of the top 20 diseases related to Malignant Pleural Mesothelioma:



Diseases related to malignant pleural mesothelioma

Clinical Features for Malignant Pleural Mesothelioma

Drugs & Therapeutics for Malignant Pleural Mesothelioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Malignant Pleural Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Pleural Mesothelioma

Search NIH Clinical Center for Malignant Pleural Mesothelioma

Search CenterWatch for Malignant Pleural Mesothelioma

Genetic Tests for Malignant Pleural Mesothelioma

Anatomical Context for Malignant Pleural Mesothelioma

Animal Models for Malignant Pleural Mesothelioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Malignant Pleural Mesothelioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.8GSTT2, MSLN, GDF10, ITLN1, LPAR2, PPP1R15A

Publications for Malignant Pleural Mesothelioma

Sources:
51PubMed
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Articles related to Malignant Pleural Mesothelioma:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
BAP1 Protein is a Progression Factor in Malignant Pleural Mesothelioma. (23963927)
2014
2
Relationship between 18 FDG PET-CT findings and the survival of 177 patients with malignant pleural mesothelioma. (23690193)
2013
3
Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1I+-MUC1 pathway. (23879962)
2013
4
Protumorigenic effects of mir-145 loss in malignant pleural mesothelioma. (24240684)
2013
5
Treatment of malignant pleural mesothelioma by fibroblast activation protein-specific re-directed T cells. (23937772)
2013
6
Which type of surgery should become the preferred procedure for malignant pleural mesothelioma: extrapleural pneumonectomy or extended pleurectomy? (23991301)
2013
7
Therapies currently in Phase II trials for malignant pleural mesothelioma. (23815672)
2013
8
Up-regulation of DDX39 in human malignant pleural mesothelioma cell lines compared to normal pleural mesothelial cells. (23749908)
2013
9
SMO expression level correlates with overall survival in patients with malignant pleural mesothelioma. (23379358)
2013
10
Malignant pleural mesothelioma in a patient with systemic sclerosis: the first report. (22777314)
2013
11
Lung volume measurements as a surrogate marker for patient response in malignant pleural mesothelioma. (23486268)
2013
12
The issue of studies evaluating biomarkers which predict outcome after pemetrexed-based chemotherapy in malignant pleural mesothelioma. (23857409)
2013
13
The state of the art in the technical performance of lung-sparing operations for malignant pleural mesothelioma. (24216529)
2013
14
Intensity-modulated radiotherapy and volumetric-modulated arc therapy for malignant pleural mesothelioma after extrapleural pleuropneumonectomy. (23835378)
2013
15
'It's all bad news': the first 3 months following a diagnosis of malignant pleural mesothelioma. (22903737)
2013
16
Factors predicting poor survival after lung-sparing radical pleurectomy of IMIG stage III malignant pleural mesothelioma. (23242984)
2013
17
G-CSF-producing malignant pleural mesothelioma: an autopsy case report with literature review. (21911431)
2012
18
Optimization of response classification criteria for patients with malignant pleural mesothelioma. (23059782)
2012
19
Continued pemetrexed and platin-based chemotherapy in patients with malignant pleural mesothelioma (MPM): value of 18F-FDG-PET/CT. (21129871)
2012
20
Cyberknife radiosurgery for focal paravertebral recurrence after radical pleurectomy/decortication in malignant pleural mesothelioma. (22290898)
2012
21
Hemithoracic intensity-modulated radiotherapy using helical tomotherapy for patients after extrapleural pneumonectomy for malignant pleural mesothelioma. (22374401)
2012
22
In reply to L. Ceresoli et al. "Adjuvant radiotherapy for malignant pleural mesothelioma: challenges and pitfalls". (23237332)
2012
23
Extrapleural pneumonectomy in malignant pleural mesothelioma. (21914759)
2011
24
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma. (21642991)
2011
25
Cul4A is an oncogene in malignant pleural mesothelioma. (19929949)
2011
26
PET-CT in the diagnosis of localized malignant pleural mesothelioma. (22040794)
2011
27
A case of malignant pleural mesothelioma with osseous and cartilaginous differentiation. (21079518)
2011
28
Comparison between plasma and serum osteopontin levels: usefulness in diagnosis of epithelial malignant pleural mesothelioma. (20878622)
2010
29
Pemetrexed for malignant pleural mesothelioma: Is it a standard second-line therapy? (21114772)
2010
30
Malignant pleural mesothelioma presenting as an acute surgical abdomen due to metastatic jejunal perforation. (20228599)
2010
31
The sensitivity of cytologic evaluation of pleural fluid in the diagnosis of malignant mesothelioma. (20049969)
2010
32
Malignant pleural mesothelioma detected by spontaneous pneumothorax. (20799022)
2010
33
Prevalence of in vitro chemotherapeutic drug resistance in primary malignant pleural mesothelioma: result in a cohort of 203 resection specimens. (20653100)
2010
34
Prominent in Situ Component in a Pleural Malignant Mesothelioma. (20643671)
2010
35
Life after first-line chemotherapy in malignant pleural mesothelioma: a North-East England experience. (20346340)
2010
36
Neurotensin expression and outcome of malignant pleural mesothelioma. (19932148)
2010
37
Tissue and serum EGFR as prognostic factors in malignant pleural mesothelioma. (20347505)
2010
38
Phase II study of asparagine-glycine-arginine-human tumor necrosis factor alpha, a selective vascular targeting agent, in previously treated patients with malignant pleural mesothelioma. (20406925)
2010
39
Immunocytochemistry of CD146 is useful to discriminate between malignant pleural mesothelioma and reactive mesothelium. (20657552)
2010
40
Expression of GATA-6 transcription factor in pleural malignant mesothelioma and metastatic pulmonary adenocarcinoma. (19060016)
2009
41
Clinical utility of diagnostic markers for malignant pleural mesothelioma. (19522163)
2009
42
Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes. (18301236)
2008
43
Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2. (18754873)
2008
44
Diagnosis of pleural malignant mesothelioma by EUS-guided FNA (with video). (18951127)
2008
45
A phase II study of intrapleural immuno-chemotherapy, pleurectomy/decortication, radiotherapy, systemic chemotherapy and long-term sub-cutaneous IL-2 in stage II-III malignant pleural mesothelioma. (17188885)
2007
46
Osteopontin is linked to p65 and MMP-9 expression in pulmonary adenocarcinoma but not in malignant pleural mesothelioma. (17493236)
2007
47
Phase II study of erlotinib in patients with malignant pleural mesothelioma: a Southwest Oncology Group Study. (17557954)
2007
48
Restored expression of the MYO18B gene suppresses orthotopic growth and the production of bloody pleural effusion by human malignant pleural mesothelioma cells in SCID mice. (17294804)
2006
49
Metabolic genotypes as modulators of asbestos-related pleural malignant mesothelioma risk: a comparison of Finnish and Italian populations. (16697254)
2006
50
Palliative and therapeutic activity of IL-2 immunotherapy in unresectable malignant pleural mesothelioma with pleural effusion: Results of a phase II study on 31 consecutive patients. (11165411)
2001

Genetic Variations for Malignant Pleural Mesothelioma

Expression for genes affiliated with Malignant Pleural Mesothelioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Malignant Pleural Mesothelioma

Search GEO for disease gene expression data for Malignant Pleural Mesothelioma.

Pathways for genes affiliated with Malignant Pleural Mesothelioma

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore
See all sources

Pathways related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7GSTM3, GSTA4, GSTA2, GSTT2
2
Hide members
10.7GSTA4, GSTA2, GSTT2, GSTM3
3
Glutathione metabolism
Hide members
10.7GSTA2, GSTT2, GSTM3, GSTA4

Compounds for genes affiliated with Malignant Pleural Mesothelioma

Sources:
45Novoseek, 24HMDB, 11DrugBank
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Compounds related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1noradrenochrome45 2411.9GSTT2, GSTA2, GSTM3, GSTA4
2hydrochloric acid45 2411.9GSTT2, GSTA4, GSTM3, GSTA2
3adrenochrome45 2411.8GSTA2, GSTT2, GSTM3, GSTA4
4gsts4510.8GSTA4, GSTM3, GSTT2, GSTA2
5Glutathione11 2411.7GSTT2, GSTA2, GSTA4, GSTM3
6sulfate45 2411.7GSTT2, GSTA4, GSTA2, GSTM3
7Vitamin E1110.6GSTM3, GSTA2
8b 7234510.5CALB2, MSLN, CEACAM7
9mucicarmine4510.3CALB2, CEACAM7

GO Terms for genes affiliated with Malignant Pleural Mesothelioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.6CEACAM7, MSLN, ITLN1

Biological processes related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680510.6GSTA4, GSTM3, GSTA2
2glutathione derivative biosynthetic processGO:190168710.5GSTA4, GSTM3, GSTA2
3glutathione metabolic processGO:00674910.3GSTA4, GSTM3, GSTA2

Molecular functions related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00436410.7GSTA4, GSTM3, GSTT2, GSTA2

Products for genes affiliated with Malignant Pleural Mesothelioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Malignant Pleural Mesothelioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet