MCID: MLG079
MIFTS: 48

Malignant Pleural Mesothelioma malady

Cancer diseases category

Summaries for Malignant Pleural Mesothelioma

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32MalaCards
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MalaCards: Malignant Pleural Mesothelioma, also known as malignant mesothelioma of the pleura, is related to malignant mesothelioma and lung cancer. An important gene associated with Malignant Pleural Mesothelioma is GSTT2 (glutathione S-transferase theta 2), and among its related pathways are Biological oxidations and Drug metabolism - cytochrome P450. The compounds noradrenochrome and hydrochloric acid have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and testes, and related mouse phenotype normal.

Aliases & Classifications for Malignant Pleural Mesothelioma

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant pleural mesothelioma 8 10 60
malignant mesothelioma of the pleura 8
malignant mesothelioma of pleura 8
pleural malignant mesothelioma 44
mesothelioma of pleura 8


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Disease Ontology8 DOID:7474
NCIt39 C7376
ICD1025 C45.0

Related Diseases for Malignant Pleural Mesothelioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malignant Pleural Mesothelioma family:

Benign Pleural Mesothelioma

Diseases related to Malignant Pleural Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mesothelioma32.3CALB2, CT49, CD7, MSLN
2lung cancer30.9CT49, BIRC7, MSLN, CEACAM7, TPBG, GSTM3
3adenocarcinoma30.8CALB2, CT49, MSLN, CEACAM7, TPBG
4squamous cell carcinoma30.5CALB2, CT49, MSLN, CEACAM7, TPBG, GSTM3
5benign mesothelioma30.5CALB2, CT49, MSLN, CEACAM7
6cervical cancer30.2CEACAM7
7asbestosis30.2MSLN
8pleural cancer10.8
9malignant epithelial mesothelioma10.6
10sarcomatoid mesothelioma10.6
11benign pleural mesothelioma10.3
12cervicitis10.3
13esophageal cancer10.3
14esophagitis10.3
15mediastinitis10.3
16pneumothorax10.3
17lymphohistiocytoid mesothelioma10.3
18burns10.2
19membranous glomerulonephritis10.2
20newcastle disease10.2
21vaccinia10.2
22malignant biphasic mesothelioma10.2
23ataxia telangiectasia10.2
24megakaryocytic tumor10.2
25intussusception10.2
26clear cell sarcoma10.2
27malignant hyperthermia10.2
28duodenitis10.2
29hypercalcemia10.2
30angiosarcoma10.2
31diffuse glomerulonephritis10.2
32endometriosis10.2
33glomerulonephritis10.2
34lung adenocarcinoma10.2
35lung squamous cell carcinoma10.2
36pleural empyema10.2
37renal cell carcinoma10.2
38sarcoma10.2
39stomatitis10.2
40thoracic cancer10.2
41vasculitis10.2
42benign fibrous mesothelioma10.2
43colorectal cancer10.0CT49, LPAR2, BIRC7, CEACAM7, TPBG, GSTA2
44breast cancer10.0LPAR2, MSLN, CEACAM7, TPBG, GSTA2, GSTM3
45adenoma10.0CALB2, CT49, CEACAM7, GSTA2, GSTA4
46melanoma10.0CALB2, IRF9, CT49, BIRC7, CEACAM7, TPBG
47colon cancer10.0CALB2, CT49, LPAR2, CEACAM7
48leukemia10.0GSTA4, GSTA2, CD7, PPP1R15A
49stomach cancer10.0LPAR2, CEACAM7, TPBG
50hepatocellular carcinoma10.0CT49, CEACAM7, GSTA2, GSTA4

Graphical network of the top 20 diseases related to Malignant Pleural Mesothelioma:



Diseases related to malignant pleural mesothelioma

Clinical Features for Malignant Pleural Mesothelioma

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Drugs & Therapeutics for Malignant Pleural Mesothelioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Malignant Pleural Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Pleural Mesothelioma

Search NIH Clinical Center for Malignant Pleural Mesothelioma

Search CenterWatch for Malignant Pleural Mesothelioma

Genetic Tests for Malignant Pleural Mesothelioma

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Anatomical Context for Malignant Pleural Mesothelioma

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32MalaCards
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MalaCards organs/tissues related to Malignant Pleural Mesothelioma:

32
Lung, Endothelial, Testes, T cells, Lymph node, Bone, Brain, Placenta, Skin, Breast, Spinal cord, Tongue

Animal Models for Malignant Pleural Mesothelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Pleural Mesothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.8GSTT2, MSLN, GDF10, ITLN1, LPAR2, PPP1R15A

Publications for Malignant Pleural Mesothelioma

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50PubMed
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Articles related to Malignant Pleural Mesothelioma:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
Small orangiophilic squamous-like cells: An underrecognized and useful morphological feature for the diagnosis of malignant mesothelioma in pleural effusion cytology. (23983174)
2014
2
ERCC1, MLH1, MSH2, MSH6, and I^III-tubulin: resistance proteins associated with response and outcome to platinum-based chemotherapy in malignant pleural mesothelioma. (23810210)
2013
3
Patterns of care for malignant pleural mesothelioma patients compensated by the Dust Diseases Board in New South Wales, Australia. (22909129)
2013
4
Expression and role of GLUT-1, MCT-1, and MCT-4 in malignant pleural mesothelioma. (23187830)
2013
5
Preclinical demonstration of synergistic Active Nutrients/Drug (AND) combination as a potential treatment for malignant pleural mesothelioma. (23526965)
2013
6
Quality of life and personality traits in patients with malignant pleural mesothelioma and their first-degree caregivers. (23983468)
2013
7
Malignant pleural mesothelioma: incidence, etiology, diagnosis, treatment, and occupational health. (23720698)
2013
8
Surgical management of malignant pleural mesothelioma. (23206719)
2013
9
Pleurodesis outcome in malignant pleural mesothelioma. (23299964)
2013
10
The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma. (24168922)
2013
11
Malignant pleural mesothelioma in a child with ataxia-telangiectasia. (22511568)
2013
12
Raltitrexed plus cisplatin is cost-effective compared with pemetrexed plus cisplatin in patients with malignant pleural mesothelioma. (21937141)
2012
13
First-line chemotherapy with liposomal doxorubicin plus cisplatin for patients with advanced malignant pleural mesothelioma: phase II trial. (22353806)
2012
14
Pemetrexed in malignant pleural mesothelioma and the clinical outcome. (21651743)
2012
15
MPM: Malignant Pleural Mesothelioma. (23977552)
2012
16
Overexpression and potential targeting of the oncofoetal antigen 5T4 in malignant pleural mesothelioma. (22498111)
2012
17
Role of conservative (palliative) care-only in the management of advanced malignant pleural mesothelioma. (22993354)
2012
18
Perifosine as a potential novel anti-cancer agent inhibits EGFR/MET-AKT axis in malignant pleural mesothelioma. (22590625)
2012
19
Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker. (22051404)
2012
20
Radical pleurectomy and intraoperative photodynamic therapy for malignant pleural mesothelioma. (22541196)
2012
21
Utilisation of a thoracic oncology database to capture radiological and pathological images for evaluation of response to chemotherapy in patients with malignant pleural mesothelioma. (23103606)
2012
22
Role of transcription factor Sp1 in the quercetin-mediated inhibitory effect on human malignant pleural mesothelioma. (22842769)
2012
23
Accuracy of diagnostic biopsy for the histological subtype of malignant pleural mesothelioma. (21266919)
2011
24
Extrapleural pneumonectomy or supportive care: treatment of malignant pleural mesothelioma? (21388982)
2011
25
Pleomorphic epithelioid diffuse malignant pleural mesothelioma: a clinicopathological review and conceptual proposal to reclassify as biphasic or sarcomatoid mesothelioma. (21358344)
2011
26
The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma. (21294125)
2011
27
Summary of prognostic factors and patient selection for extrapleural pneumonectomy in the treatment of malignant pleural mesothelioma. (21512863)
2011
28
Photodynamic therapy for malignant pleural mesothelioma: the future of treatment? (21348586)
2011
29
Phase II study of gemcitabine plus docetaxel as second-line treatment in malignant pleural mesothelioma: a single institution study. (20142722)
2011
30
Staging of patients after extrapleural pneumonectomy for malignant pleural mesothelioma--institutional review and current update. (21303872)
2011
31
Radiotherapy in pleural malignant mesothelioma: why not! In regard to Scorsetti et al. (Int J Radiat Oncol Biol Phys 2010;77:942-949); Krayenbuehl et al. (Int J Radiat Oncol Biol Phys 2010;78:628-634). (21353165)
2011
32
High-dose-rate surface brachytherapy to boost elongated, curvilinear incisional scars after extrapleural pneumonectomy for malignant pleural mesothelioma treated with adjuvant intensity-modulated radiation therapy. (19846346)
2010
33
Multimodality treatment of malignant pleural mesothelioma with or without immunotherapy: does it change anything? (20053697)
2010
34
Diagnostic usefulness of endobronchial ultrasound-guided transbronchial needle aspiration in a case with malignant pleural mesothelioma. (20190476)
2010
35
Soluble mesothelin-related protein in pleural effusion from patients with malignant pleural mesothelioma. (22993544)
2010
36
Proposed adjustments to pathologic staging of epithelial malignant pleural mesothelioma based on analysis of 354 cases. (20108310)
2010
37
A diagnostic assay based on microRNA expression accurately identifies malignant pleural mesothelioma. (20864637)
2010
38
Proton therapy for malignant pleural mesothelioma after extrapleural pleuropneumonectomy. (20385451)
2010
39
Localized malignant pleural mesothelioma showing a thoracic mass and metastasizing to the stomach. (20371957)
2010
40
Surgical options in malignant pleural mesothelioma: extrapleural pneumonectomy or pleurectomy/decortication. (19822286)
2009
41
Prognostic significance of p16/cdkn2a loss in pleural malignant mesotheliomas. (18958493)
2008
42
The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas. (18949431)
2008
43
Other thoracic cancers. Malignant pleural mesothelioma: biology and diagnosis]. (18971844)
2008
44
Protein kinase C beta in malignant pleural mesothelioma. (18765998)
2008
45
Four-modality therapy in malignant pleural mesothelioma: a phase II study. (17410047)
2007
46
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells. (16434257)
2006
47
Prognostic significance of vascular endothelial growth factor, tumor necrosis, and mitotic activity index in malignant pleural mesothelioma. (16304288)
2005
48
Pemetrexed (Alimta, MTA, multitargeted antifolate, LY231514) for malignant pleural mesothelioma. (12917819)
2003
49
Pseudomesotheliomatous angiosarcoma: a pleuropulmonary lesion simulating malignant pleural mesothelioma. (9181362)
1997
50
Local adoptive immunotherapy using lymphokine-activated killer cells and interleukin-2 against malignant pleural mesothelioma: report of two cases. (1753419)
1991

Genetic Variations for Malignant Pleural Mesothelioma

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Expression for genes affiliated with Malignant Pleural Mesothelioma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Pleural Mesothelioma

Search GEO for disease gene expression data for Malignant Pleural Mesothelioma.

Pathways for genes affiliated with Malignant Pleural Mesothelioma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7GSTA4, GSTM3, GSTT2, GSTA2
2
Hide members
10.7GSTA2, GSTT2, GSTM3, GSTA4
3
Glutathione metabolism
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10.7GSTA4, GSTM3, GSTT2, GSTA2

Compounds for genes affiliated with Malignant Pleural Mesothelioma

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44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1noradrenochrome44 2411.9GSTA4, GSTM3, GSTT2, GSTA2
2hydrochloric acid44 2411.9GSTA2, GSTT2, GSTM3, GSTA4
3adrenochrome44 2411.8GSTA4, GSTM3, GSTT2, GSTA2
4gsts4410.8GSTA2, GSTT2, GSTM3, GSTA4
5Glutathione11 2411.7GSTA4, GSTM3, GSTT2, GSTA2
6sulfate44 2411.7GSTA2, GSTT2, GSTM3, GSTA4
7Vitamin E1110.6GSTM3, GSTA2
8b 7234410.5CEACAM7, MSLN, CALB2
9mucicarmine4410.3CEACAM7, CALB2

GO Terms for genes affiliated with Malignant Pleural Mesothelioma

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16Gene Ontology
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Cellular components related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.6CEACAM7, MSLN, ITLN1

Biological processes related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680510.6GSTA4, GSTM3, GSTA2
2glutathione derivative biosynthetic processGO:190168710.5GSTA4, GSTM3, GSTA2
3glutathione metabolic processGO:00674910.3GSTA4, GSTM3, GSTA2

Molecular functions related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00436410.7GSTA4, GSTM3, GSTT2, GSTA2

Products for genes affiliated with Malignant Pleural Mesothelioma

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  • Antibodies
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Sources for Malignant Pleural Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet