MCID: MLG079
MIFTS: 48

Malignant Pleural Mesothelioma malady

Cancer diseases category

Summaries for Malignant Pleural Mesothelioma

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32MalaCards
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MalaCards: Malignant Pleural Mesothelioma, also known as malignant mesothelioma of the pleura, is related to malignant mesothelioma and lung cancer. An important gene associated with Malignant Pleural Mesothelioma is GSTT2 (glutathione S-transferase theta 2), and among its related pathways are Biological oxidations and Drug metabolism - cytochrome P450. The compounds noradrenochrome and hydrochloric acid have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and testes, and related mouse phenotype normal.

Aliases & Classifications for Malignant Pleural Mesothelioma

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant pleural mesothelioma 8 10 60
malignant mesothelioma of the pleura 8
malignant mesothelioma of pleura 8
pleural malignant mesothelioma 44
mesothelioma of pleura 8


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Disease Ontology8 DOID:7474
NCIt39 C7376
ICD1025 C45.0

Related Diseases for Malignant Pleural Mesothelioma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Malignant Pleural Mesothelioma family:

Benign Pleural Mesothelioma

Diseases related to Malignant Pleural Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 56)
idRelated DiseaseScoreTop Affiliating Genes
1malignant mesothelioma32.3CALB2, CT49, CD7, MSLN
2lung cancer30.9CT49, BIRC7, MSLN, CEACAM7, TPBG, GSTM3
3adenocarcinoma30.8CALB2, CT49, MSLN, CEACAM7, TPBG
4squamous cell carcinoma30.5CALB2, CT49, MSLN, CEACAM7, TPBG, GSTM3
5benign mesothelioma30.5CALB2, CT49, MSLN, CEACAM7
6cervical cancer30.2CEACAM7
7asbestosis30.2MSLN
8pleural cancer10.8
9malignant epithelial mesothelioma10.6
10sarcomatoid mesothelioma10.6
11benign pleural mesothelioma10.3
12cervicitis10.3
13esophageal cancer10.3
14esophagitis10.3
15mediastinitis10.3
16pneumothorax10.3
17lymphohistiocytoid mesothelioma10.3
18burns10.2
19membranous glomerulonephritis10.2
20newcastle disease10.2
21vaccinia10.2
22malignant biphasic mesothelioma10.2
23ataxia telangiectasia10.2
24megakaryocytic tumor10.2
25intussusception10.2
26clear cell sarcoma10.2
27malignant hyperthermia10.2
28duodenitis10.2
29hypercalcemia10.2
30angiosarcoma10.2
31diffuse glomerulonephritis10.2
32endometriosis10.2
33glomerulonephritis10.2
34lung adenocarcinoma10.2
35lung squamous cell carcinoma10.2
36pleural empyema10.2
37renal cell carcinoma10.2
38sarcoma10.2
39stomatitis10.2
40thoracic cancer10.2
41vasculitis10.2
42benign fibrous mesothelioma10.2
43colorectal cancer10.0CT49, LPAR2, BIRC7, CEACAM7, TPBG, GSTA2
44breast cancer10.0LPAR2, MSLN, CEACAM7, TPBG, GSTA2, GSTM3
45adenoma10.0CALB2, CT49, CEACAM7, GSTA2, GSTA4
46melanoma10.0CALB2, IRF9, CT49, BIRC7, CEACAM7, TPBG
47colon cancer10.0CALB2, CT49, LPAR2, CEACAM7
48leukemia10.0GSTA4, GSTA2, CD7, PPP1R15A
49stomach cancer10.0LPAR2, CEACAM7, TPBG
50hepatocellular carcinoma10.0CT49, CEACAM7, GSTA2, GSTA4

Graphical network of the top 20 diseases related to Malignant Pleural Mesothelioma:



Diseases related to malignant pleural mesothelioma

Clinical Features for Malignant Pleural Mesothelioma

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Drugs & Therapeutics for Malignant Pleural Mesothelioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Malignant Pleural Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Pleural Mesothelioma

Search NIH Clinical Center for Malignant Pleural Mesothelioma

Search CenterWatch for Malignant Pleural Mesothelioma

Genetic Tests for Malignant Pleural Mesothelioma

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Anatomical Context for Malignant Pleural Mesothelioma

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32MalaCards
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MalaCards organs/tissues related to Malignant Pleural Mesothelioma:

32
Lung, Endothelial, Testes, T cells, Lymph node, Bone, Brain, Placenta, Skin, Breast, Spinal cord, Tongue

Animal Models for Malignant Pleural Mesothelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Malignant Pleural Mesothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.8GSTT2, MSLN, GDF10, ITLN1, LPAR2, PPP1R15A

Publications for Malignant Pleural Mesothelioma

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50PubMed
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Articles related to Malignant Pleural Mesothelioma:

(show top 50)    (show all 676)
idTitleAuthorsYear
1
Patterns of disease progression on 18F-fluorodeoxyglucose positron emission tomography-computed tomography in patients with malignant pleural mesothelioma undergoing multimodality therapy with pleurectomy/decortication. (23963351)
2013
2
PTEN protein expression in malignant pleural mesothelioma. (23242608)
2013
3
Gene expression profile of aquaporin 1 and associated interactors in malignant pleural mesothelioma. (23313295)
2013
4
Thymidylate synthase and folyl-polyglutamate synthase are not clinically useful markers of response to pemetrexed in patients with malignant pleural mesothelioma. (23486267)
2013
5
Multimodal therapy of malignant pleural mesothelioma: is the replacement of radical surgery imminent? (23171517)
2013
6
Sarcomatoid malignant pleural mesothelioma confirmed by full-thickness biopsy. (24033973)
2013
7
Use of cancer therapy at the end of life in patients with malignant pleural mesothelioma. (23408016)
2013
8
Tomotherapy after pleurectomy or decortication or biopsy for malignant pleural mesothelioma. (23584307)
2013
9
Phase II study of first-line bortezomib and cisplatin in malignant pleural mesothelioma and prospective validation of progression free survival rate as a primary end-point for mesothelioma clinical trials (European Organisation for Research and Treatment of Cancer 08052). (23791541)
2013
10
Hyaluronic acid in the pleural fluid of patients with malignant pleural mesothelioma. (23790737)
2013
11
A phase II study of intermittent sunitinib malate as second-line therapy in progressive malignant pleural mesothelioma. (22895142)
2012
12
A biomarker profile for predicting efficacy of cisplatin-vinorelbine therapy in malignant pleural mesothelioma. (22960937)
2012
13
Malignant pleural mesothelioma: factors influencing the prognosis. (23413596)
2012
14
Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis. (22412141)
2012
15
Systemic treatment of malignant pleural mesothelioma. (22409465)
2012
16
Pleural intensity-modulated radiotherapy for malignant pleural mesothelioma. (22607910)
2012
17
Effects of hyaluronic acid and CD44 interaction on the proliferation and invasiveness of malignant pleural mesothelioma. (22886525)
2012
18
Prospective study on functional results after lung-sparing radical pleurectomy in the management of malignant pleural mesothelioma. (22722790)
2012
19
Sustained expression of steroid receptor coactivator SRC-2/TIF-2 is associated with better prognosis in malignant pleural mesothelioma. (22011668)
2012
20
Intratumoral Wnt2B expression affects tumor proliferation and survival in malignant pleural mesothelioma patients. (22969998)
2012
21
Important recent insights into the genetics and biology of malignant pleural mesothelioma. (23977537)
2012
22
Long term survival after trimodal therapy in malignant pleural mesothelioma. (23135895)
2012
23
Malignant pleural mesothelioma. (22223867)
2012
24
Anti-angiogenic therapies for malignant pleural mesothelioma. (22519641)
2012
25
Malignant pleural mesothelioma presenting with a spontaneous hydropneumothorax: a report of 2 cases. (21924581)
2012
26
BioKnife, a uPA activity-dependent oncolytic Sendai virus, eliminates pleural spread of malignant mesothelioma via simultaneous stimulation of uPA expression. (22314292)
2012
27
Fine-needle aspiration biopsies for gene expression ratio-based diagnostic and prognostic tests in malignant pleural mesothelioma. (21088255)
2011
28
Temsirolimus inhibits malignant pleural mesothelioma growth in vitro and in vivo: synergism with chemotherapy. (21358348)
2011
29
Validation of tissue microarray technology in malignant pleural mesothelioma. (21233673)
2011
30
eComment: What is the best way to diagnose and stage malignant pleural mesothelioma? (21555444)
2011
31
Establishment of a cell line from a Japanese patient useful for generating an in vivo model of malignant pleural mesothelioma. (21205078)
2011
32
Retreatment of recurrent malignant pleural mesothelioma with cisplatin and pemetrexed. (20224880)
2010
33
Malignant pleural mesothelioma: a population-based study of survival. (20975379)
2010
34
Integrated positron emission tomography-computed tomography does not accurately stage intrathoracic disease of patients undergoing trimodality therapy for malignant pleural mesothelioma. (20514576)
2010
35
Minute localized malignant pleural mesothelioma coexisting with multiple adenocarcinomas. (20155346)
2010
36
Prognostic factors for 100 patients with malignant pleural mesothelioma. (20439224)
2010
37
Surgery for malignant pleural mesothelioma. (20524919)
2010
38
Survival and relapse pattern after trimodality therapy for malignant pleural mesothelioma. (19908112)
2009
39
Increasing of malignant pleural mesothelioma: burning issue in Split-Dalmatian County, Croatia. (20102076)
2009
40
Pleural malignant mesothelioma with invasive micropapillary component and its association with pulmonary metastasis. (20021613)
2009
41
Novel dual targeting strategy with vandetanib induces tumor cell apoptosis and inhibits angiogenesis in malignant pleural mesothelioma cells expressing RET oncogenic rearrangement. (18364248)
2008
42
Biomarkers for prevention and early diagnosis of malignant pleural mesothelioma]. (18409713)
2007
43
A retrospective analysis of malignant pleural mesothelioma patients treated either with chemotherapy or best supportive care between 1990 and 2005 A single institution experience. (17174436)
2007
44
Soluble mesothelin-related peptides in the diagnosis of malignant pleural mesothelioma. (16456138)
2006
45
Suppression of pro-metastasis phenotypes expression in malignant pleural mesothelioma by the PI3K inhibitor LY294002 or the MEK inhibitor UO126. (16619474)
2006
46
Pleural malignant mesothelioma, genetic susceptibility and asbestos exposure. (15993904)
2005
47
Up-regulation of thioredoxin and thioredoxin reductase in human malignant pleural mesothelioma. (11307155)
2001
48
Thrombospondin-1 expression and clinical implications in malignant pleural mesothelioma. (10375104)
1999
49
Malignant mesothelioma: immunohistochemistry and DNA ploidy analysis as methods to differentiate mesothelioma from benign reactive mesothelial cell proliferation and adenocarcinoma in pleural and peritoneal effusions. (12046609)
1996
50
Lung surfactant protein-A and carcinoembryonic antigen in pleural effusions due to lung adenocarcinoma and malignant mesothelioma. (7789485)
1995

Genetic Variations for Malignant Pleural Mesothelioma

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Expression for genes affiliated with Malignant Pleural Mesothelioma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Pleural Mesothelioma

Search GEO for disease gene expression data for Malignant Pleural Mesothelioma.

Pathways for genes affiliated with Malignant Pleural Mesothelioma

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Pathways related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.7GSTA4, GSTM3, GSTT2, GSTA2
2
Hide members
10.7GSTA2, GSTT2, GSTM3, GSTA4
3
Glutathione metabolism
Hide members
10.7GSTA4, GSTM3, GSTT2, GSTA2

Compounds for genes affiliated with Malignant Pleural Mesothelioma

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44Novoseek, 24HMDB, 11DrugBank
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Compounds related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1noradrenochrome44 2411.9GSTA4, GSTM3, GSTT2, GSTA2
2hydrochloric acid44 2411.9GSTA2, GSTT2, GSTM3, GSTA4
3adrenochrome44 2411.8GSTA4, GSTM3, GSTT2, GSTA2
4gsts4410.8GSTA2, GSTT2, GSTM3, GSTA4
5Glutathione11 2411.7GSTA4, GSTM3, GSTT2, GSTA2
6sulfate44 2411.7GSTA2, GSTT2, GSTM3, GSTA4
7Vitamin E1110.6GSTM3, GSTA2
8b 7234410.5CEACAM7, MSLN, CALB2
9mucicarmine4410.3CEACAM7, CALB2

GO Terms for genes affiliated with Malignant Pleural Mesothelioma

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16Gene Ontology
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Cellular components related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1anchored to membraneGO:03122510.6CEACAM7, MSLN, ITLN1

Biological processes related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:00680510.6GSTA4, GSTM3, GSTA2
2glutathione derivative biosynthetic processGO:190168710.5GSTA4, GSTM3, GSTA2
3glutathione metabolic processGO:00674910.3GSTA4, GSTM3, GSTA2

Molecular functions related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00436410.7GSTA4, GSTM3, GSTT2, GSTA2

Products for genes affiliated with Malignant Pleural Mesothelioma

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Sources for Malignant Pleural Mesothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet