MCID: MLG079
MIFTS: 45

Malignant Pleural Mesothelioma malady

Cancer diseases category

Summaries for Malignant Pleural Mesothelioma

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34MalaCards
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MalaCards: Malignant Pleural Mesothelioma, also known as malignant mesothelioma of the pleura, is related to lung cancer and malignant mesothelioma. An important gene associated with Malignant Pleural Mesothelioma is MIR34B (microRNA 34b), and among its related pathways are miRNAs involved in DDR and 2 Naphthylamine and 2 Nitronaphtalene metabolism. The compounds vitamin e and S-(PGJ2)-glutathione have been mentioned in the context of this disorder. Affiliated tissues include lung, endothelial and testes.

Aliases & Classifications for Malignant Pleural Mesothelioma

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

malignant pleural mesothelioma 9 11 63
malignant mesothelioma of the pleura 9
malignant mesothelioma of pleura 9
pleural malignant mesothelioma 46
mesothelioma of pleura 9


External Ids:

Disease Ontology9 DOID:7474
NCIt41 C7376
ICD1026 C45.0

Related Diseases for Malignant Pleural Mesothelioma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Malignant Pleural Mesothelioma family:

Benign Pleural Mesothelioma

Diseases related to Malignant Pleural Mesothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer30.9TPBG, MSLN, BIRC7, GSTM3
2malignant mesothelioma30.3CD7, MSLN
3endotheliitis10.6
4adenocarcinoma10.6
5cervicitis10.4
6esophageal cancer10.4
7esophagitis10.4
8mediastinitis10.4
9pneumothorax10.4
10spontaneous pneumothorax10.4
11burns10.2
12newcastle disease10.2
13membranous glomerulonephritis10.2
14intussusception10.2
15asbestosis10.2
16clear cell sarcoma10.2
17duodenitis10.2
18hypercalcemia10.2
19sarcomatoid mesothelioma10.2
20ataxia telangiectasia10.2
21angiosarcoma10.2
22cervical cancer10.2
23endometriosis10.2
24glomerulonephritis10.2
25lung adenocarcinoma10.2
26renal cell carcinoma10.2
27sarcoma10.2
28stomatitis10.2
29thoracic cancer10.2
30vasculitis10.2
31wilms tumor10.2
32cerebellar degeneration10.2
33paraneoplastic cerebellar degeneration10.2
34ataxia10.2
35back pain10.2
36dysphagia10.2
37hypoxia10.2
38thromboembolism10.2
39pulmonary function10.2
40right aortic arch10.2
41benign fibrous mesothelioma10.2
42benign pleural mesothelioma10.2
43benign mesothelioma10.2
44solitary fibrous tumor10.2
45schistosomiasis10.0GSTA4, GSTA2
46kidney cancer10.0BIRC7, MSLN, TPBG
47bladder carcinoma in situ10.0GSTA4, GSTA2
48toxic encephalopathy10.0GSTA4, GSTA2
49colorectal cancer9.8TPBG, BIRC7, GSTM3, GSTA2, GSTA4
50breast cancer9.8TPBG, MSLN, GSTM3, GSTA2, GSTA4

Graphical network of the top 20 diseases related to Malignant Pleural Mesothelioma:



Diseases related to malignant pleural mesothelioma

Symptoms for Malignant Pleural Mesothelioma

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Drugs & Therapeutics for Malignant Pleural Mesothelioma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Malignant Pleural Mesothelioma

Drug clinical trials:

Search ClinicalTrials for Malignant Pleural Mesothelioma

Search NIH Clinical Center for Malignant Pleural Mesothelioma

Search CenterWatch for Malignant Pleural Mesothelioma

Genetic Tests for Malignant Pleural Mesothelioma

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Anatomical Context for Malignant Pleural Mesothelioma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Malignant Pleural Mesothelioma:

34
Lung, Endothelial, Testes, T cells, Lymph node, Bone, Brain, Placenta, Breast, Spinal cord, Tongue

Animal Models for Malignant Pleural Mesothelioma or affiliated genes

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Publications for Malignant Pleural Mesothelioma

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Sources:
53PubMed
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Articles related to Malignant Pleural Mesothelioma:

(show top 50)    (show all 608)
idTitleAuthorsYear
1
BAP1 Protein is a Progression Factor in Malignant Pleural Mesothelioma. (23963927)
2014
2
Does miR-1 Play a Role in Malignant Pleural Mesothelioma Development and Progression? (24297134)
2013
3
Patterns of disease progression on 18F-fluorodeoxyglucose positron emission tomography-computed tomography in patients with malignant pleural mesothelioma undergoing multimodality therapy with pleurectomy/decortication. (23963351)
2013
4
Is galectin-3 antibody a useful marker in the diagnosis of malignant pleural mesothelioma? (23537297)
2013
5
Antitumor effect and antiangiogenic potential of the mTOR inhibitor temsirolimus against malignant pleural mesothelioma. (24378576)
2013
6
Malignant Pleural Mesothelioma Presenting as Acute Empyema with Severe Leukocytosis. (24088916)
2013
7
ERCC1, MLH1, MSH2, MSH6, and I^III-tubulin: resistance proteins associated with response and outcome to platinum-based chemotherapy in malignant pleural mesothelioma. (23810210)
2013
8
Relationship between 18 FDG PET-CT findings and the survival of 177 patients with malignant pleural mesothelioma. (23690193)
2013
9
Patterns of care for malignant pleural mesothelioma patients compensated by the Dust Diseases Board in New South Wales, Australia. (22909129)
2013
10
Radiotherapy for the treatment of pain in malignant pleural mesothelioma: A systematic review. (24314815)
2013
11
Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1I+-MUC1 pathway. (23879962)
2013
12
Hyperthermic intraoperative pleural cisplatin chemotherapy extends interval to recurrence and survival among low-risk patients with malignant pleural mesothelioma undergoing surgical macroscopic complete resection. (23434448)
2013
13
A phase II study of intermittent sunitinib malate as second-line therapy in progressive malignant pleural mesothelioma. (22895142)
2012
14
Raltitrexed plus cisplatin is cost-effective compared with pemetrexed plus cisplatin in patients with malignant pleural mesothelioma. (21937141)
2012
15
FDG PET/CT Response Evaluation in Malignant Pleural Mesothelioma Patients Treated with Talc Pleurodesis and Chemotherapy. (22670158)
2012
16
A biomarker profile for predicting efficacy of cisplatin-vinorelbine therapy in malignant pleural mesothelioma. (22960937)
2012
17
Photodynamic therapy for malignant pleural mesothelioma. (23055222)
2012
18
Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma. (22734486)
2012
19
Malignant pleural mesothelioma: factors influencing the prognosis. (23413596)
2012
20
Multicentric study on malignant pleural mesothelioma in Turkey: clinicopathologic and survival characteristics of 282 patients. (22722923)
2012
21
Data-driven information retrieval in heterogeneous collections of transcriptomics data links SIM2s to malignant pleural mesothelioma. (22106335)
2012
22
High prevalence of serum antibodies reacting with simian virus 40 capsid protein mimotopes in patients affected by malignant pleural mesothelioma. (23071320)
2012
23
Serum mesothelin for diagnosing malignant pleural mesothelioma: an individual patient data meta-analysis. (22412141)
2012
24
Clinical and pathological features of three-year survivors of malignant pleural mesothelioma following extrapleural pneumonectomy. (21310625)
2011
25
Lack of evidence in malignant pleural mesothelioma surgery. (21345821)
2011
26
Extrapleural pneumonectomy in malignant pleural mesothelioma. (21914759)
2011
27
The evolution of multimodality therapy for malignant pleural mesothelioma. (21404104)
2011
28
Advances in the biology of malignant pleural mesothelioma. (21288646)
2011
29
Comparison between plasma and serum osteopontin levels: usefulness in diagnosis of epithelial malignant pleural mesothelioma. (20878622)
2010
30
High-dose-rate surface brachytherapy to boost elongated, curvilinear incisional scars after extrapleural pneumonectomy for malignant pleural mesothelioma treated with adjuvant intensity-modulated radiation therapy. (19846346)
2010
31
Translational therapies for malignant pleural mesothelioma. (20406091)
2010
32
Multimodality treatment of malignant pleural mesothelioma with or without immunotherapy: does it change anything? (20053697)
2010
33
Pemetrexed for malignant pleural mesothelioma: Is it a standard second-line therapy? (21114772)
2010
34
Trimodality therapy for malignant pleural mesothelioma: results from an EORTC phase II multicentre trial. (20525721)
2010
35
A rare cause of dysphagia: malignant pleural mesothelioma in the posterior mediastinum. (20868849)
2010
36
Retreatment of recurrent malignant pleural mesothelioma with cisplatin and pemetrexed. (20224880)
2010
37
Malignant pleural mesothelioma presenting as an acute surgical abdomen due to metastatic jejunal perforation. (20228599)
2010
38
Brain metastasis in malignant pleural mesothelioma presenting as intratumoral hemorrhage. (21123992)
2010
39
Placenta growth factor expression has prognostic value in malignant pleural mesothelioma. (19632388)
2009
40
Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells. (19233506)
2009
41
Protumorigenic role of HAPLN1 and its IgV domain in malignant pleural mesothelioma. (19351750)
2009
42
Survival and relapse pattern after trimodality therapy for malignant pleural mesothelioma. (19908112)
2009
43
Tract metastasis from previously unknown malignant pleural mesothelioma: a case report. (19830019)
2009
44
Unusual features of malignant pleural mesothelioma metastatic to the mediastinal lymph nodes. (18301236)
2008
45
Inhibitor of apoptosis proteins are regulated by tumour necrosis factor-alpha in malignant pleural mesothelioma. (17253597)
2007
46
Radiation-induced cellular DNA damage repair response enhances viral gene therapy efficacy in the treatment of malignant pleural mesothelioma. (17080237)
2007
47
Epidemiology, molecular biology, diagnostic and therapeutic strategy of malignant pleural mesothelioma in 2007 - an update]. (18235409)
2007
48
A phase I clinical trial of single-dose intrapleural IFN-beta gene transfer for malignant pleural mesothelioma and metastatic pleural effusions: high rate of antitumor immune responses. (17671130)
2007
49
Squamous cell carcinoma of the lung producing granulocyte colony-stimulating factor and resembling a malignant pleural mesothelioma. (15005252)
2004
50
Fibrinolytic system in plasma and pleural fluid in malignant pleural mesothelioma. (8897701)
1996

Variations for Malignant Pleural Mesothelioma

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Expression for genes affiliated with Malignant Pleural Mesothelioma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Malignant Pleural Mesothelioma

Search GEO for disease gene expression data for Malignant Pleural Mesothelioma.

Pathways for genes affiliated with Malignant Pleural Mesothelioma

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 56Reactome, 52PharmGKB
See all sources

Pathways related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9MIR34B, MIR92A1
29.7GSTA4, GSTA2
39.6MIR34B, MIR92A1, MIR625
4
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
9.1GSTA4, GSTT2, GSTA2, GSTM3
5
Show member pathways
9.1GSTM3, GSTA2, GSTT2, GSTA4
6
Show member pathways
9.1GSTM3, GSTA2, GSTT2, GSTA4

Compounds for genes affiliated with Malignant Pleural Mesothelioma

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Sources:
52PharmGKB, 12DrugBank, 25HMDB, 46Novoseek
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Compounds related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1vitamin e52 1210.6GSTA2, GSTM3
2S-(PGJ2)-glutathione259.4GSTM3, GSTA4, GSTT2, GSTA2
34-Hydroxyestrone-2-S-glutathione259.4GSTM3, GSTA2, GSTT2, GSTA4
4Estrone-2,3-quinone259.4GSTA4, GSTT2, GSTA2, GSTM3
5Estrone-3,4-quinone259.4GSTA4, GSTT2, GSTA2, GSTM3
6noradrenochrome46 2510.4GSTA4, GSTT2, GSTA2, GSTM3
72-Hydroxyestrone-1-S-glutathione259.4GSTA4, GSTT2, GSTA2, GSTM3
82-Hydroxyestrone-4-S-glutathione259.3GSTA4, GSTT2, GSTA2, GSTM3
9hydrochloric acid46 2510.3GSTM3, GSTA2, GSTT2, GSTA4
10adrenochrome46 2510.3GSTM3, GSTA2, GSTT2, GSTA4
11gsts469.2GSTA4, GSTT2, GSTA2, GSTM3
12Glutathione25 1210.2GSTM3, GSTA2, GSTT2, GSTA4
13Water259.1GSTA4, GSTT2, GSTA2, GSTM3
14sulfate46 2510.0GSTM3, GSTA2, GSTT2, GSTA4

GO Terms for genes affiliated with Malignant Pleural Mesothelioma

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Sources:
17Gene Ontology
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Biological processes related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1xenobiotic metabolic processGO:0068059.4GSTA4, GSTA2, GSTM3
2glutathione derivative biosynthetic processGO:19016879.3GSTA4, GSTA2, GSTM3
3glutathione metabolic processGO:0067499.1GSTA4, GSTA2, GSTM3

Molecular functions related to Malignant Pleural Mesothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:0043649.1GSTA4, GSTT2, GSTA2, GSTM3

Products for genes affiliated with Malignant Pleural Mesothelioma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Malignant Pleural Mesothelioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet